Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP07363
DateThu Jan 5 11:00:16 GMT 2012
Unique Job ID8dd1e07e1a175ea2

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2ch4A_
Top template information
PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew
Confidence and coverage
Confidence:100.0% Coverage: 48%
316 residues ( 48% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
561 residues ( 86%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MSMDISDFYQTFFDEADELLADMEQHLLVLQPEAPDAEQLNAIFRAAHSIKGGAGTFGFS
Secondary structure 
SS confidence 
Disorder  ????
?
???
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  VLQETTHLMENLLDEARRGEMQLNTDIINLFLETKDIMQEQLDAYKQSQEPDAASFDYIC
Secondary structure 
SS confidence 
Disorder 
?
????
????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  QALRQLALEAKGETPSAVTRLSVVAKSEPQDEQSRSQSPRRIILSRLKAGEVDLLEEELG
Secondary structure 
SS confidence 
Disorder 
????????????????????????????????????
??????????
???
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  HLTTLTDVVKGADSLSAILPGDIAEDDITAVLCFVIEADQITFETVEVSPKISTPPVLKL
Secondary structure 
SS confidence 
Disorder  ????????????
????????????????????????
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  AAEQAPTGRVEREKTTRSNESTSIRVAVEKVDQLINLVGELVITQSMLAQRSSELDPVNH
Secondary structure 
SS confidence 
Disorder  ?????????????????????
?
?????
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  GDLITSMGQLQRNARDLQESVMSIRMMPMEYVFSRYPRLVRDLAGKLGKQVELTLVGSST
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  ELDKSLIERIIDPLTHLVRNSLDHGIELPEKRLAAGKNSVGNLILSAEHQGGNICIEVTD
Secondary structure 
SS confidence 
Disorder 
?
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  DGAGLNRERILAKAASQGLTVSENMSDDEVAMLIFAPGFSTAEQVTDVSGRGVGMDVVKR
Secondary structure 
SS confidence 
Disorder 
???
???
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  NIQKMGGHVEIQSKQGTGTTIRILLPLTLAILDGMSVRVADEVFILPLNAVMESLQPREA
Secondary structure 
SS confidence 
Disorder 
??
Disorder confidence 
 
   .........550.........560.........570.........580.........590.........600
Sequence  DLHPLAGGERVLEVRGEYLPIVELWKVFNVAGAKTEATQGIVVILQSGGRRYALLVDQLI
Secondary structure 
SS confidence 
Disorder 
?
?????????
Disorder confidence 
 
   .........610.........620.........630.........640.........650....
Sequence  GQHQVVVKNLESNYRKVPGISAATILGDGSVALIVDVSALQAINREQRMANTAA
Secondary structure 
SS confidence 
Disorder 
?
??
?????????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2ch4 chain A

3D model

Region: 324 - 641
Aligned: 316
Modelled: 318
Confidence: 100.0%
Identity: 44%
PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew

Phyre2

PDB 1b3q chain A

3D model

Region: 262 - 641
Aligned: 364
Modelled: 379
Confidence: 100.0%
Identity: 42%
PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase

Phyre2

PDB 1i58 chain A

3D model

Region: 324 - 508
Aligned: 185
Modelled: 185
Confidence: 100.0%
Identity: 50%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 2q8f chain A

3D model

Region: 205 - 506
Aligned: 276
Modelled: 281
Confidence: 100.0%
Identity: 10%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1

Phyre2

PDB 3d2r chain B

3D model

Region: 204 - 508
Aligned: 278
Modelled: 284
Confidence: 100.0%
Identity: 12%
PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp

Phyre2

PDB 2bu8 chain A

3D model

Region: 204 - 508
Aligned: 274
Modelled: 284
Confidence: 100.0%
Identity: 13%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands

Phyre2

PDB 1gjv chain A

3D model

Region: 234 - 508
Aligned: 243
Modelled: 254
Confidence: 100.0%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s

Phyre2

PDB 1y8o chain A

3D model

Region: 204 - 506
Aligned: 270
Modelled: 278
Confidence: 100.0%
Identity: 11%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex

Phyre2

PDB 3d36 chain B

3D model

Region: 272 - 508
Aligned: 196
Modelled: 216
Confidence: 100.0%
Identity: 23%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda

Phyre2

PDB 2c2a chain A

3D model

Region: 244 - 508
Aligned: 227
Modelled: 244
Confidence: 100.0%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein

Phyre2

PDB 1gkz chain A domain 2

3D model

Region: 327 - 506
Aligned: 151
Modelled: 159
Confidence: 100.0%
Identity: 20%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2

PDB 3a0r chain A

3D model

Region: 247 - 508
Aligned: 216
Modelled: 230
Confidence: 99.9%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)

Phyre2

PDB 2c2a chain A domain 2

3D model

Region: 325 - 508
Aligned: 146
Modelled: 163
Confidence: 99.9%
Identity: 18%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1jm6 chain A domain 2

3D model

Region: 329 - 507
Aligned: 150
Modelled: 158
Confidence: 99.9%
Identity: 19%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2

PDB 3a0t chain A

3D model

Region: 322 - 508
Aligned: 148
Modelled: 166
Confidence: 99.9%
Identity: 19%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)

Phyre2

PDB 1b3q chain A domain 2

3D model

Region: 508 - 641
Aligned: 132
Modelled: 134
Confidence: 99.9%
Identity: 36%
Fold: OB-fold
Superfamily: CheW-like
Family: CheW-like

Phyre2

PDB 1id0 chain A

3D model

Region: 325 - 506
Aligned: 142
Modelled: 147
Confidence: 99.9%
Identity: 17%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1bxd chain A

3D model

Region: 333 - 514
Aligned: 145
Modelled: 147
Confidence: 99.9%
Identity: 26%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1i5n chain A

3D model

Region: 4 - 131
Aligned: 128
Modelled: 128
Confidence: 99.9%
Identity: 90%
Fold: Four-helical up-and-down bundle
Superfamily: Histidine-containing phosphotransfer domain, HPT domain
Family: Chemotaxis protein CheA P1 domain

Phyre2

PDB 1ysr chain A domain 1

3D model

Region: 333 - 507
Aligned: 128
Modelled: 141
Confidence: 99.9%
Identity: 21%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2
1
c2ch4A_
2
c1b3qA_
3
d1i58a_
4
c2q8fA_
5
c3d2rB_
6
c2bu8A_
7
c1gjvA_
8
c1y8oA_
9
c3d36B_
10
c2c2aA_
11
d1gkza2
12
c3a0rA_
13
d2c2aa2
14
d1jm6a2
15
c3a0tA_
16
d1b3qa2
17
d1id0a_
18
d1bxda_
19
d1i5na_
20
d1ysra1
21
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2ch4A_
100.0 44 PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew
2c1b3qA_
100.0 42 PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase
3d1i58a_
100.0 50 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
4c2q8fA_
100.0 10 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1
5c3d2rB_
100.0 12 PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp
6c2bu8A_
100.0 13 PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands
7c1gjvA_
100.0 15 PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s
8c1y8oA_
100.0 11 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex
9c3d36B_
100.0 23 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda
10c2c2aA_
100.0 15 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein
11d1gkza2
100.0 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
12c3a0rA_
99.9 15 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)
13d2c2aa2
99.9 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
14d1jm6a2
99.9 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
15c3a0tA_
99.9 19 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)
16d1b3qa2
99.9 36 Fold:OB-fold
Superfamily:CheW-like
Family:CheW-like
17d1id0a_
99.9 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
18d1bxda_
99.9 26 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
19d1i5na_
99.9 90 Fold:Four-helical up-and-down bundle
Superfamily:Histidine-containing phosphotransfer domain, HPT domain
Family:Chemotaxis protein CheA P1 domain
20d1ysra1
99.9 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
21c3kyiA_
not modelled 99.9 23 PDB header:transferase
Chain: A: PDB Molecule:putative histidine protein kinase;
PDBTitle: crystal structure of the phosphorylated p1 domain of chea3 in complex2 with chey6 from r. sphaeroides
22c2lchA_
not modelled 99.9 23 PDB header:de novo protein
Chain: A: PDB Molecule:protein or38;
PDBTitle: solution nmr structure of a protein with a redesigned hydrophobic2 core, northeast structural genomics consortium target or38
23d1tqga_
not modelled 99.8 33 Fold:Four-helical up-and-down bundle
Superfamily:Histidine-containing phosphotransfer domain, HPT domain
Family:Chemotaxis protein CheA P1 domain
24c3gieA_
not modelled 99.8 14 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase desk;
PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp
25c3jz3B_
not modelled 99.8 21 PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec
26d1r62a_
not modelled 99.8 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
27c3zxqA_
not modelled 99.7 24 PDB header:transferase
Chain: A: PDB Molecule:hypoxia sensor histidine kinase response regulator dost;
PDBTitle: crystal structure of the atp-binding domain of mycobacterium2 tuberculosis dost
28c3ehgA_
not modelled 99.7 17 PDB header:transferase
Chain: A: PDB Molecule:sensor kinase (yocf protein);
PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp
29d2hkja3
not modelled 99.7 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
30c3zxoB_
not modelled 99.7 28 PDB header:transferase
Chain: B: PDB Molecule:redox sensor histidine kinase response regulator devs;
PDBTitle: crystal structure of the mutant atp-binding domain of2 mycobacterium tuberculosis doss
31c2ho9A_
not modelled 99.6 16 PDB header:signaling protein
Chain: A: PDB Molecule:chemotaxis protein chew;
PDBTitle: solution structure of chemotaxi protein chew from2 escherichia coli
32d2ch4w1
not modelled 99.5 15 Fold:OB-fold
Superfamily:CheW-like
Family:CheW-like
33c2zbkB_
not modelled 99.5 16 PDB header:isomerase
Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b;
PDBTitle: crystal structure of an intact type ii dna topoisomerase:2 insights into dna transfer mechanisms
34d1th8a_
not modelled 99.5 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
35c2qdlB_
not modelled 99.5 17 PDB header:signaling protein
Chain: B: PDB Molecule:chemotaxis signal transduction protein;
PDBTitle: crystal structure of scaffolding protein ttchew from2 thermoanaerobacter tengcongensis
36c1mx0D_
not modelled 99.5 16 PDB header:isomerase
Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b;
PDBTitle: structure of topoisomerase subunit
37c2q2eB_
not modelled 99.5 24 PDB header:isomerase
Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b;
PDBTitle: crystal structure of the topoisomerase vi holoenzyme from2 methanosarcina mazei
38d1h7sa2
not modelled 99.4 27 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
39d1bkna2
not modelled 99.3 24 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
40d1b63a2
not modelled 99.3 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
41d1ixma_
not modelled 99.0 10 Fold:Sporulation response regulatory protein Spo0B
Superfamily:Sporulation response regulatory protein Spo0B
Family:Sporulation response regulatory protein Spo0B
42d1y8oa2
not modelled 99.0 15 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
43d2r25a1
not modelled 98.8 23 Fold:Four-helical up-and-down bundle
Superfamily:Histidine-containing phosphotransfer domain, HPT domain
Family:Phosphorelay protein-like
44c3na3A_
not modelled 98.7 22 PDB header:protein binding
Chain: A: PDB Molecule:dna mismatch repair protein mlh1;
PDBTitle: mutl protein homolog 1 isoform 1 from homo sapiens
45d1wn0a1
not modelled 98.6 12 Fold:Four-helical up-and-down bundle
Superfamily:Histidine-containing phosphotransfer domain, HPT domain
Family:Phosphorelay protein-like
46d1y6da_
not modelled 98.5 20 Fold:Four-helical up-and-down bundle
Superfamily:Histidine-containing phosphotransfer domain, HPT domain
Family:Phosphorelay protein luxU
47d1yvia1
not modelled 98.5 16 Fold:Four-helical up-and-down bundle
Superfamily:Histidine-containing phosphotransfer domain, HPT domain
Family:Phosphorelay protein-like
48c3myfB_
not modelled 98.5 21 PDB header:transferase
Chain: B: PDB Molecule:sensor protein;
PDBTitle: the crystal structure of the hpt domain from the hpt sensor hybrid2 histidine kinase from shewanella to 1.80a
49c3iqtA_
not modelled 98.4 21 PDB header:transferase
Chain: A: PDB Molecule:signal transduction histidine-protein kinase bara;
PDBTitle: structure of the hpt domain of sensor protein bara from escherichia2 coli cft073.
50c3h4lB_
not modelled 98.3 20 PDB header:dna binding protein, protein binding
Chain: B: PDB Molecule:dna mismatch repair protein pms1;
PDBTitle: crystal structure of n terminal domain of a dna repair protein
51d2a0ba_
not modelled 98.3 25 Fold:Four-helical up-and-down bundle
Superfamily:Histidine-containing phosphotransfer domain, HPT domain
Family:Aerobic respiration control sensor protein, ArcB
52d1sr2a_
not modelled 98.2 16 Fold:Four-helical up-and-down bundle
Superfamily:Histidine-containing phosphotransfer domain, HPT domain
Family:Sensor-like histidine kinase YojN, C-terminal domain
53d1kija2
not modelled 98.1 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
54c1kijB_
not modelled 98.1 24 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: crystal structure of the 43k atpase domain of thermus thermophilus2 gyrase b in complex with novobiocin
55d1ei1a2
not modelled 98.0 24 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
56d1pvga2
not modelled 98.0 15 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
57d2ooca1
not modelled 98.0 19 Fold:Four-helical up-and-down bundle
Superfamily:Histidine-containing phosphotransfer domain, HPT domain
Family:SphA-like
58c3ke6A_
not modelled 98.0 32 PDB header:unknown function
Chain: A: PDB Molecule:protein rv1364c/mt1410;
PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis
59c1bknA_
not modelled 97.9 26 PDB header:dna repair
Chain: A: PDB Molecule:mutl;
PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl
60c1ei1B_
not modelled 97.8 25 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase b;
PDBTitle: dimerization of e. coli dna gyrase b provides a structural mechanism2 for activating the atpase catalytic center
61d1s16a2
not modelled 97.8 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
62c1ea6A_
not modelled 97.8 27 PDB header:dna repair
Chain: A: PDB Molecule:pms1 protein homolog 2;
PDBTitle: n-terminal 40kda fragment of nhpms2 complexed with adp
63c1s16B_
not modelled 97.7 21 PDB header:isomerase
Chain: B: PDB Molecule:topoisomerase iv subunit b;
PDBTitle: crystal structure of e. coli topoisomerase iv pare 43kda subunit2 complexed with adpnp
64c3iedA_
not modelled 97.7 23 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein;
PDBTitle: crystal structure of n-terminal domain of plasmodium falciparum hsp902 (pf14_0417) in complex with amppn
65c1y4sA_
not modelled 97.6 25 PDB header:chaperone
Chain: A: PDB Molecule:chaperone protein htpg;
PDBTitle: conformation rearrangement of heat shock protein 90 upon2 adp binding
66c1zxnB_
not modelled 97.6 16 PDB header:isomerase
Chain: B: PDB Molecule:dna topoisomerase ii, alpha isozyme;
PDBTitle: human dna topoisomerase iia atpase/adp
67c3pehB_
not modelled 97.6 19 PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin homolog;
PDBTitle: crystal structure of the n-terminal domain of an hsp90 from plasmodium2 falciparum, pfl1070c in the presence of a thienopyrimidine derivative
68c1qzrA_
not modelled 97.6 18 PDB header:isomerase
Chain: A: PDB Molecule:dna topoisomerase ii;
PDBTitle: crystal structure of the atpase region of saccharomyces cerevisiae2 topoisomerase ii bound to icrf-187 (dexrazoxane)
69c2cg9A_
not modelled 97.6 24 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex
70c2iopD_
not modelled 97.5 28 PDB header:chaperone
Chain: D: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp
71d1uyla_
not modelled 97.5 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
72c2akpA_
not modelled 97.4 23 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: hsp90 delta24-n210 mutant
73c2fwyA_
not modelled 97.4 17 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein hsp 90-alpha;
PDBTitle: structure of human hsp90-alpha bound to the potent water2 soluble inhibitor pu-h64
74c2iorA_
not modelled 97.4 25 PDB header:chaperone
Chain: A: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of the n-terminal domain of htpg, the2 escherichia coli hsp90, bound to adp
75c3lnuA_
not modelled 97.4 21 PDB header:isomerase
Chain: A: PDB Molecule:topoisomerase iv subunit b;
PDBTitle: crystal structure of pare subunit
76d1uyma_
not modelled 97.4 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
77c3g7bB_
not modelled 97.3 28 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: staphylococcus aureus gyrase b co-complex with inhibitor
78d1qy5a_
not modelled 97.2 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
79d2iwxa1
not modelled 97.2 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
80c2o1uA_
not modelled 97.1 26 PDB header:chaperone
Chain: A: PDB Molecule:endoplasmin;
PDBTitle: structure of full length grp94 with amp-pnp bound
81c1zwhA_
not modelled 97.1 23 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: yeast hsp82 in complex with the novel hsp90 inhibitor radester amine
82d2gqpa1
not modelled 97.1 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
83d1s14a_
not modelled 97.0 25 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
84c2o1wB_
not modelled 96.0 26 PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin;
PDBTitle: structure of n-terminal plus middle domains (n+m) of grp94
85c3cwvB_
not modelled 94.2 13 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase, b subunit, truncated;
PDBTitle: crystal structure of b-subunit of the dna gyrase from myxococcus2 xanthus
86d1b3qa1
not modelled 93.6 39 Fold:ROP-like
Superfamily:Homodimeric domain of signal transducing histidine kinase
Family:Homodimeric domain of signal transducing histidine kinase
87c2v6lI_
not modelled 61.8 19 PDB header:protein transport
Chain: I: PDB Molecule:mxih;
PDBTitle: molecular model of a type iii secretion system needle
88c1qr0A_
not modelled 61.4 18 PDB header:transferase
Chain: A: PDB Molecule:4'-phosphopantetheinyl transferase sfp;
PDBTitle: crystal structure of the 4'-phosphopantetheinyl transferase sfp-2 coenzyme a complex
89c3o38D_
not modelled 56.9 32 PDB header:oxidoreductase
Chain: D: PDB Molecule:short chain dehydrogenase;
PDBTitle: crystal structure of a short chain dehydrogenase from mycobacterium2 smegmatis
90d1wmaa1
not modelled 50.0 19 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Tyrosine-dependent oxidoreductases
91c3ck6E_
not modelled 47.8 14 PDB header:structural protein
Chain: E: PDB Molecule:putative membrane transport protein;
PDBTitle: crystal structure of zntb cytoplasmic domain from vibrio2 parahaemolyticus rimd 2210633
92d2g0ua1
not modelled 41.9 14 Fold:Long alpha-hairpin
Superfamily:MxiH-like
Family:MxiH-like
93c2jowA_
not modelled 40.6 21 PDB header:transport protein
Chain: A: PDB Molecule:protein prgi;
PDBTitle: differences in the electrostatic surfaces of the type iii2 secretion needle proteins
94c2cg5A_
not modelled 39.8 15 PDB header:transferase/hydrolase
Chain: A: PDB Molecule:l-aminoadipate-semialdehyde dehydrogenase-
PDBTitle: structure of aminoadipate-semialdehyde dehydrogenase-2 phosphopantetheinyl transferase in complex with cytosolic3 acyl carrier protein and coenzyme a
95d1eyba_
not modelled 38.1 27 Fold:Double-stranded beta-helix
Superfamily:RmlC-like cupins
Family:Homogentisate dioxygenase
96c2o98P_
not modelled 37.0 44 PDB header:protein binding
Chain: P: PDB Molecule:plasma membrane h+ atpase;
PDBTitle: structure of the 14-3-3 / h+-atpase plant complex
97c3k31B_
not modelled 36.1 14 PDB header:oxidoreductase
Chain: B: PDB Molecule:enoyl-(acyl-carrier-protein) reductase;
PDBTitle: crystal structure of eonyl-(acyl-carrier-protein) reductase from2 anaplasma phagocytophilum in complex with nad at 1.9a resolution
98d2ca5a1
not modelled 33.7 21 Fold:Long alpha-hairpin
Superfamily:MxiH-like
Family:MxiH-like
99c3gdfA_
not modelled 33.7 36 PDB header:oxidoreductase
Chain: A: PDB Molecule:probable nadp-dependent mannitol dehydrogenase;
PDBTitle: crystal structure of the nadp-dependent mannitol dehydrogenase from2 cladosporium herbarum.
100c3gr6A_
not modelled 33.2 20 PDB header:oxidoreductase
Chain: A: PDB Molecule:enoyl-[acyl-carrier-protein] reductase [nadh];
PDBTitle: crystal structure of the staphylococcus aureus enoyl-acyl2 carrier protein reductase (fabi) in complex with nadp and3 triclosan
101c1ey2A_
not modelled 32.3 27 PDB header:oxidoreductase
Chain: A: PDB Molecule:homogentisate 1,2-dioxygenase;
PDBTitle: human homogentisate dioxygenase with fe(ii)
102d1d7oa_
not modelled 30.3 17 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Tyrosine-dependent oxidoreductases
103d1g0oa_
not modelled 28.5 24 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Tyrosine-dependent oxidoreductases
104c3itdA_
not modelled 27.7 27 PDB header:oxidoreductase
Chain: A: PDB Molecule:17beta-hydroxysteroid dehydrogenase;
PDBTitle: crystal structure of an inactive 17beta-hydroxysteroid dehydrogenase2 (y167f mutated form) from fungus cochliobolus lunatus
105c2qioA_
not modelled 26.9 14 PDB header:unknown function
Chain: A: PDB Molecule:enoyl-(acyl-carrier-protein) reductase;
PDBTitle: x-ray structure of enoyl-acyl carrier protein reductase from bacillus2 anthracis with triclosan
106c3m51P_
not modelled 25.4 50 PDB header:protein binding
Chain: P: PDB Molecule:n.plumbaginifolia h+-translocating atpase mrna;
PDBTitle: structure of the 14-3-3/pma2 complex stabilized by pyrrolidone1
107d1aipc1
not modelled 25.4 37 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:TS-N domain
108d1efub3
not modelled 25.1 26 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:TS-N domain
109c2k42A_
not modelled 25.1 25 PDB header:signaling protein
Chain: A: PDB Molecule:wiskott-aldrich syndrome protein;
PDBTitle: solution structure of the gtpase binding domain of wasp in2 complex with espfu, an ehec effector
110d1ej5a_
not modelled 25.0 27 Fold:Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
Superfamily:Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
Family:Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
111d1xb2b1
not modelled 25.0 21 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:TS-N domain
112d2o23a1
not modelled 24.2 15 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Tyrosine-dependent oxidoreductases
113c3clwF_
not modelled 24.1 18 PDB header:structural genomics, unknown function
Chain: F: PDB Molecule:conserved exported protein;
PDBTitle: crystal structure of conserved exported protein from bacteroides2 fragilis
114d1xmta_
not modelled 24.0 15 Fold:Acyl-CoA N-acyltransferases (Nat)
Superfamily:Acyl-CoA N-acyltransferases (Nat)
Family:N-acetyl transferase, NAT
115c3fmsA_
not modelled 23.8 10 PDB header:transcription regulator
Chain: A: PDB Molecule:transcriptional regulator, gntr family;
PDBTitle: crystal structure of tm0439, a gntr transcriptional2 regulator
116c2o2sA_
not modelled 23.7 25 PDB header:oxidoreductase
Chain: A: PDB Molecule:enoyl-acyl carrier reductase;
PDBTitle: the structure of t. gondii enoyl acyl carrier protein reductase in2 complex with nad and triclosan
117d1pn0a3
not modelled 23.1 19 Fold:FAD-linked reductases, C-terminal domain
Superfamily:FAD-linked reductases, C-terminal domain
Family:PHBH-like
118d1b74a1
not modelled 23.0 38 Fold:ATC-like
Superfamily:Aspartate/glutamate racemase
Family:Aspartate/glutamate racemase
119c3zr6A_
not modelled 22.9 24 PDB header:hydrolase
Chain: A: PDB Molecule:galactocerebrosidase;
PDBTitle: structure of galactocerebrosidase from mouse in complex with2 galactose
120d2bela_
not modelled 22.6 13 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Tyrosine-dependent oxidoreductases

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0