Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP32670
DateThu Jan 5 11:49:59 GMT 2012
Unique Job ID80d2f4070b402b64

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2hwgA_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of phosphorylated enzyme i of the2 phosphoenolpyruvate:sugar phosphotransferase system
Confidence and coverage
Confidence:100.0% Coverage: 68%
565 residues ( 68% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
794 residues ( 95%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MALIVEFICELPNGVHARPASHVETLCNTFSSQIEWHNLRTDRKGNAKSALALIGTDTLA
Secondary structure 
SS confidence 
Disorder  ???
???????
?
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  GDNCQLLISGADEQEAHQRLSQWLRDEFPHCDAPLAEVKSDELEPLPVSLTNLNPQIIRA
Secondary structure 
SS confidence 
Disorder 
?
????????????????????????????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  RTVCSGSAGGILTPISSLDLNALGNLPAAKGVDAEQSALENGLTLVLKNIEFRLLDSDGA
Secondary structure 
SS confidence 
Disorder 
?????????????
?????
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  TSAILEAHRSLAGDTSLREHLLAGVSAGLSCAEAIVASANHFCEEFSRSSSSYLQERALD
Secondary structure 
SS confidence 
Disorder 
???
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  VRDVCFQLLQQIYGEQRFPAPGKLTQPAICMADELTPSQFLELDKNHLKGLLLKSGGTTS
Secondary structure 
SS confidence 
Disorder 
?????????
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  HTVILARSFNIPTLVGVDIDALTPWQQQTIYIDGNAGAIVVEPGEAVARYYQQEARVQDA
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  LREQQRVWLTQQARTADGIRIEIAANIAHSVEAQAAFGNGAEGVGLFRTEMLYMDRTSAP
Secondary structure 
SS confidence 
Disorder 
??
?
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  GESELYNIFCQALESANGRSIIVRTMDIGGDKPVDYLNIPAEANPFLGYRAVRIYEEYAS
Secondary structure 
SS confidence 
Disorder  ?
????
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  LFTTQLRSILRASAHGSLKIMIPMISSMEEILWVKEKLAEAKQQLRNEHIPFDEKIQLGI
Secondary structure 
SS confidence 
Disorder 
?????
Disorder confidence 
 
   .........550.........560.........570.........580.........590.........600
Sequence  MLEVPSVMFIIDQCCEEIDFFSIGSNDLTQYLLAVDRDNAKVTRHYNSLNPAFLRALDYA
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........610.........620.........630.........640.........650.........660
Sequence  VQAVHRQGKWIGLCGELGAKGSVLPLLVGLGLDELSMSAPSIPAAKARMAQLDSRECRKL
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........670.........680.........690.........700.........710.........720
Sequence  LNQAMACRTSLEVEHLLAQFRMTQQDAPLVTAECITLESDWRSKEEVLKGMTDNLLLAGR
Secondary structure 
SS confidence 
Disorder 
?
????
?
Disorder confidence 
 
   .........730.........740.........750.........760.........770.........780
Sequence  CRYPRKLEADLWAREAVFSTGLGFSFAIPHSKSEHIEQSTISVARLQAPVRWGDDEAQFI
Secondary structure 
SS confidence 
Disorder 
?
?
??
Disorder confidence 
 
   .........790.........800.........810.........820.........830...
Sequence  IMLTLNKHAAGDQHMRIFSRLARRIMHEEFRNALVNAASADAIASLLQHELEL
Secondary structure 
SS confidence 
Disorder 
???
???
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2hwg chain A

3D model

Region: 118 - 684
Aligned: 565
Modelled: 567
Confidence: 100.0%
Identity: 34%
PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of phosphorylated enzyme i of the2 phosphoenolpyruvate:sugar phosphotransferase system

Phyre2

PDB 2hro chain A

3D model

Region: 118 - 682
Aligned: 545
Modelled: 562
Confidence: 100.0%
Identity: 36%
PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of the full-lenght enzyme i of the pts system from2 staphylococcus carnosus

Phyre2

PDB 1h6z chain A

3D model

Region: 263 - 659
Aligned: 381
Modelled: 384
Confidence: 100.0%
Identity: 26%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate phosphate dikinase;
PDBTitle: 3.0 a resolution crystal structure of glycosomal pyruvate2 phosphate dikinase from trypanosoma brucei

Phyre2

PDB 2bg5 chain C

3D model

Region: 363 - 683
Aligned: 321
Modelled: 321
Confidence: 100.0%
Identity: 42%
PDB header:transferase
Chain: C: PDB Molecule:phosphoenolpyruvate-protein kinase;
PDBTitle: crystal structure of the phosphoenolpyruvate-binding enzyme2 i-domain from the thermoanaerobacter tengcongensis pep:3 sugar phosphotransferase system (pts)

Phyre2

PDB 1kbl chain A

3D model

Region: 264 - 655
Aligned: 376
Modelled: 379
Confidence: 100.0%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate phosphate dikinase;
PDBTitle: pyruvate phosphate dikinase

Phyre2

PDB 1vbh chain A

3D model

Region: 263 - 652
Aligned: 371
Modelled: 377
Confidence: 100.0%
Identity: 25%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate,orthophosphate dikinase;
PDBTitle: pyruvate phosphate dikinase with bound mg-pep from maize

Phyre2

PDB 2ols chain A

3D model

Region: 253 - 651
Aligned: 356
Modelled: 360
Confidence: 100.0%
Identity: 26%
PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate synthase;
PDBTitle: the crystal structure of the phosphoenolpyruvate synthase from2 neisseria meningitidis

Phyre2

PDB 1vbg chain A domain 1

3D model

Region: 377 - 653
Aligned: 276
Modelled: 277
Confidence: 100.0%
Identity: 26%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: Pyruvate phosphate dikinase, C-terminal domain

Phyre2

PDB 1h6z chain A domain 1

3D model

Region: 370 - 659
Aligned: 289
Modelled: 290
Confidence: 100.0%
Identity: 27%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: Pyruvate phosphate dikinase, C-terminal domain

Phyre2

PDB 1kbl chain A domain 1

3D model

Region: 379 - 651
Aligned: 272
Modelled: 273
Confidence: 100.0%
Identity: 31%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: Pyruvate phosphate dikinase, C-terminal domain

Phyre2

PDB 1eza chain A

3D model

Region: 117 - 371
Aligned: 254
Modelled: 255
Confidence: 100.0%
Identity: 22%
PDB header:phosphotransferase
Chain: A: PDB Molecule:enzyme i;
PDBTitle: amino terminal domain of enzyme i from escherichia coli nmr,2 restrained regularized mean structure

Phyre2

PDB 1zym chain A domain 2

3D model

Region: 255 - 361
Aligned: 107
Modelled: 107
Confidence: 99.9%
Identity: 23%
Fold: The "swivelling" beta/beta/alpha domain
Superfamily: Phosphohistidine domain
Family: N-terminal domain of enzyme I of the PEP:sugar phosphotransferase system

Phyre2

PDB 1zym chain A domain 1

3D model

Region: 138 - 254
Aligned: 117
Modelled: 117
Confidence: 99.9%
Identity: 24%
Fold: SAM domain-like
Superfamily: Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
Family: Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain

Phyre2

PDB 3qz6 chain A

3D model

Region: 381 - 661
Aligned: 215
Modelled: 245
Confidence: 99.9%
Identity: 21%
PDB header:lyase
Chain: A: PDB Molecule:hpch/hpai aldolase;
PDBTitle: the crystal structure of hpch/hpai aldolase from desulfitobacterium2 hafniense dcb-2

Phyre2

PDB 1dxe chain A

3D model

Region: 376 - 652
Aligned: 211
Modelled: 244
Confidence: 99.9%
Identity: 18%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: HpcH/HpaI aldolase

Phyre2

PDB 2a0j chain A

3D model

Region: 689 - 828
Aligned: 138
Modelled: 140
Confidence: 99.8%
Identity: 25%
PDB header:transferase
Chain: A: PDB Molecule:pts system, nitrogen regulatory iia protein;
PDBTitle: crystal structure of nitrogen regulatory protein iia-ntr from2 neisseria meningitidis

Phyre2

PDB 3urr chain B

3D model

Region: 689 - 829
Aligned: 137
Modelled: 141
Confidence: 99.8%
Identity: 25%
PDB header:transferase
Chain: B: PDB Molecule:pts iia-like nitrogen-regulatory protein ptsn;
PDBTitle: structure of pts iia-like nitrogen-regulatory protein ptsn (bth_i0484)2 (ptsn)

Phyre2

PDB 1izc chain A

3D model

Region: 376 - 656
Aligned: 222
Modelled: 238
Confidence: 99.8%
Identity: 19%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: HpcH/HpaI aldolase

Phyre2

PDB 1izc chain A

3D model

Region: 376 - 656
Aligned: 222
Modelled: 247
Confidence: 99.8%
Identity: 19%
PDB header:lyase
Chain: A: PDB Molecule:macrophomate synthase intermolecular diels-alderase;
PDBTitle: crystal structure analysis of macrophomate synthase

Phyre2

PDB 2hpr chain A

3D model

Region: 6 - 90
Aligned: 83
Modelled: 85
Confidence: 99.8%
Identity: 22%
Fold: HPr-like
Superfamily: HPr-like
Family: HPr-like

Phyre2

PDB 1a6j chain A

3D model

Region: 689 - 829
Aligned: 139
Modelled: 139
Confidence: 99.8%
Identity: 20%
Fold: Phoshotransferase/anion transport protein
Superfamily: Phoshotransferase/anion transport protein
Family: IIA domain of mannitol-specific and ntr phosphotransferase EII

Phyre2

PDB 3oxp chain B

3D model

Region: 689 - 829
Aligned: 136
Modelled: 135
Confidence: 99.8%
Identity: 19%
PDB header:transferase
Chain: B: PDB Molecule:phosphotransferase enzyme ii, a component;
PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution

Phyre2

PDB 3oxp chain A

3D model

Region: 689 - 829
Aligned: 136
Modelled: 135
Confidence: 99.8%
Identity: 19%
PDB header:transferase
Chain: A: PDB Molecule:phosphotransferase enzyme ii, a component;
PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution

Phyre2

PDB 3le1 chain B

3D model

Region: 3 - 88
Aligned: 84
Modelled: 84
Confidence: 99.8%
Identity: 31%
PDB header:transferase
Chain: B: PDB Molecule:phosphotransferase system, hpr-related proteins;
PDBTitle: crystal structure of apohpr monomer from thermoanaerobacter2 tengcongensis

Phyre2

PDB 1ka5 chain A

3D model

Region: 3 - 90
Aligned: 86
Modelled: 86
Confidence: 99.8%
Identity: 23%
Fold: HPr-like
Superfamily: HPr-like
Family: HPr-like

Phyre2

PDB 1mo1 chain A

3D model

Region: 3 - 88
Aligned: 84
Modelled: 82
Confidence: 99.8%
Identity: 30%
Fold: HPr-like
Superfamily: HPr-like
Family: HPr-like

Phyre2

PDB 1pch chain A

3D model

Region: 4 - 90
Aligned: 85
Modelled: 85
Confidence: 99.8%
Identity: 26%
Fold: HPr-like
Superfamily: HPr-like
Family: HPr-like

Phyre2

PDB 1qr5 chain A

3D model

Region: 3 - 90
Aligned: 86
Modelled: 86
Confidence: 99.8%
Identity: 22%
Fold: HPr-like
Superfamily: HPr-like
Family: HPr-like

Phyre2

PDB 3bjv chain A

3D model

Region: 689 - 830
Aligned: 137
Modelled: 137
Confidence: 99.8%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:rmpa;
PDBTitle: the crystal structure of a putative pts iia(ptxa) from streptococcus2 mutans

Phyre2
1
c2hwgA_
2
c2hroA_
3
c1h6zA_
4
c2bg5C_
5
c1kblA_
6
c1vbhA_
7
c2olsA_
8
d1vbga1
9
d1h6za1
10
d1kbla1
11
c1ezaA_
12
d1zyma2
13
d1zyma1
14
c3qz6A_
15
d1dxea_
16
c2a0jA_
17
c3urrB_
18
d1izca_
19
c1izcA_
20
d2hpra_
21
d1a6ja_
22
c3oxpB_
23
c3oxpA_
24
c3le1B_
25
d1ka5a_
26
27
d1mo1a_
28
d1pcha_
29
d1qr5a_
30
31
c3bjvA_
32
33
34
35
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2hwgA_
100.0 34 PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of phosphorylated enzyme i of the2 phosphoenolpyruvate:sugar phosphotransferase system
2c2hroA_
100.0 36 PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of the full-lenght enzyme i of the pts system from2 staphylococcus carnosus
3c1h6zA_
100.0 26 PDB header:transferase
Chain: A: PDB Molecule:pyruvate phosphate dikinase;
PDBTitle: 3.0 a resolution crystal structure of glycosomal pyruvate2 phosphate dikinase from trypanosoma brucei
4c2bg5C_
100.0 42 PDB header:transferase
Chain: C: PDB Molecule:phosphoenolpyruvate-protein kinase;
PDBTitle: crystal structure of the phosphoenolpyruvate-binding enzyme2 i-domain from the thermoanaerobacter tengcongensis pep:3 sugar phosphotransferase system (pts)
5c1kblA_
100.0 27 PDB header:transferase
Chain: A: PDB Molecule:pyruvate phosphate dikinase;
PDBTitle: pyruvate phosphate dikinase
6c1vbhA_
100.0 25 PDB header:transferase
Chain: A: PDB Molecule:pyruvate,orthophosphate dikinase;
PDBTitle: pyruvate phosphate dikinase with bound mg-pep from maize
7c2olsA_
100.0 26 PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate synthase;
PDBTitle: the crystal structure of the phosphoenolpyruvate synthase from2 neisseria meningitidis
8d1vbga1
100.0 26 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate phosphate dikinase, C-terminal domain
9d1h6za1
100.0 27 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate phosphate dikinase, C-terminal domain
10d1kbla1
100.0 31 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate phosphate dikinase, C-terminal domain
11c1ezaA_
100.0 22 PDB header:phosphotransferase
Chain: A: PDB Molecule:enzyme i;
PDBTitle: amino terminal domain of enzyme i from escherichia coli nmr,2 restrained regularized mean structure
12d1zyma2
99.9 23 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:Phosphohistidine domain
Family:N-terminal domain of enzyme I of the PEP:sugar phosphotransferase system
13d1zyma1
99.9 24 Fold:SAM domain-like
Superfamily:Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
Family:Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
14c3qz6A_
99.9 21 PDB header:lyase
Chain: A: PDB Molecule:hpch/hpai aldolase;
PDBTitle: the crystal structure of hpch/hpai aldolase from desulfitobacterium2 hafniense dcb-2
15d1dxea_
99.9 18 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
16c2a0jA_
99.8 25 PDB header:transferase
Chain: A: PDB Molecule:pts system, nitrogen regulatory iia protein;
PDBTitle: crystal structure of nitrogen regulatory protein iia-ntr from2 neisseria meningitidis
17c3urrB_
99.8 25 PDB header:transferase
Chain: B: PDB Molecule:pts iia-like nitrogen-regulatory protein ptsn;
PDBTitle: structure of pts iia-like nitrogen-regulatory protein ptsn (bth_i0484)2 (ptsn)
18d1izca_
99.8 19 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
19c1izcA_
99.8 19 PDB header:lyase
Chain: A: PDB Molecule:macrophomate synthase intermolecular diels-alderase;
PDBTitle: crystal structure analysis of macrophomate synthase
20d2hpra_
99.8 22 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
21d1a6ja_
99.8 20 Fold:Phoshotransferase/anion transport protein
Superfamily:Phoshotransferase/anion transport protein
Family:IIA domain of mannitol-specific and ntr phosphotransferase EII
22c3oxpB_
99.8 19 PDB header:transferase
Chain: B: PDB Molecule:phosphotransferase enzyme ii, a component;
PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution
23c3oxpA_
99.8 19 PDB header:transferase
Chain: A: PDB Molecule:phosphotransferase enzyme ii, a component;
PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution
24c3le1B_
99.8 31 PDB header:transferase
Chain: B: PDB Molecule:phosphotransferase system, hpr-related proteins;
PDBTitle: crystal structure of apohpr monomer from thermoanaerobacter2 tengcongensis
25d1ka5a_
99.8 23 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
26c2oqtD_
not modelled 99.8 14 PDB header:transferase
Chain: D: PDB Molecule:hypothetical protein spy0176;
PDBTitle: structural genomics, the crystal structure of a putative2 pts iia domain from streptococcus pyogenes m1 gas
27d1mo1a_
99.8 30 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
28d1pcha_
99.8 26 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
29d1qr5a_
99.8 22 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
30c3ihsB_
not modelled 99.8 24 PDB header:transport protein
Chain: B: PDB Molecule:phosphocarrier protein hpr;
PDBTitle: crystal structure of a phosphocarrier protein hpr from2 bacillus anthracis str. ames
31c3bjvA_
99.8 17 PDB header:transferase
Chain: A: PDB Molecule:rmpa;
PDBTitle: the crystal structure of a putative pts iia(ptxa) from streptococcus2 mutans
32c2v5jB_
not modelled 99.8 22 PDB header:lyase
Chain: B: PDB Molecule:2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase;
PDBTitle: apo class ii aldolase hpch
33d1ptfa_
not modelled 99.8 27 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
34d1xiza_
not modelled 99.8 22 Fold:Phoshotransferase/anion transport protein
Superfamily:Phoshotransferase/anion transport protein
Family:IIA domain of mannitol-specific and ntr phosphotransferase EII
35c2vwtA_
not modelled 99.8 20 PDB header:lyase
Chain: A: PDB Molecule:yfau, 2-keto-3-deoxy sugar aldolase;
PDBTitle: crystal structure of yfau, a metal ion dependent class ii2 aldolase from escherichia coli k12 - mg-pyruvate product3 complex
36d1a3aa_
not modelled 99.8 22 Fold:Phoshotransferase/anion transport protein
Superfamily:Phoshotransferase/anion transport protein
Family:IIA domain of mannitol-specific and ntr phosphotransferase EII
37d2nzul1
not modelled 99.7 22 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
38d1cm3a_
not modelled 99.7 26 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
39c2oq3A_
not modelled 99.7 16 PDB header:transferase
Chain: A: PDB Molecule:mannitol-specific cryptic phosphotransferase
PDBTitle: solution structure of the mannitol- specific cryptic2 phosphotransferase enzyme iia cmtb from escherichia coli
40d1vbga2
not modelled 99.7 23 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:Phosphohistidine domain
Family:Pyruvate phosphate dikinase, central domain
41d1zvvj1
not modelled 99.7 31 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
42d1kbla2
not modelled 99.7 27 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:Phosphohistidine domain
Family:Pyruvate phosphate dikinase, central domain
43d1h6za2
not modelled 99.7 25 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:Phosphohistidine domain
Family:Pyruvate phosphate dikinase, central domain
44c3t07D_
not modelled 99.3 21 PDB header:transferase/transferase inhibitor
Chain: D: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of s. aureus pyruvate kinase in complex with a2 naturally occurring bis-indole alkaloid
45c3qqwC_
not modelled 99.3 13 PDB header:lyase
Chain: C: PDB Molecule:putative citrate lyase;
PDBTitle: crystal structure of a hypothetical lyase (reut_b4148) from ralstonia2 eutropha jmp134 at 2.44 a resolution
46c1sgjB_
not modelled 99.2 14 PDB header:lyase
Chain: B: PDB Molecule:citrate lyase, beta subunit;
PDBTitle: crystal structure of citrate lyase beta subunit
47c2e28A_
not modelled 99.2 24 PDB header:transferase
Chain: A: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure analysis of pyruvate kinase from bacillus2 stearothermophilus
48d1sgja_
not modelled 99.1 14 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
49d2g50a2
not modelled 99.0 16 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
50d1e0ta2
not modelled 99.0 14 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
51c3r4iB_
not modelled 99.0 17 PDB header:lyase
Chain: B: PDB Molecule:citrate lyase;
PDBTitle: crystal structure of a citrate lyase (bxe_b2899) from burkholderia2 xenovorans lb400 at 2.24 a resolution
52d1a3xa2
not modelled 99.0 18 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
53d1pkla2
not modelled 98.9 21 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
54d1u5ha_
not modelled 98.9 14 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
55c1u5vA_
not modelled 98.8 13 PDB header:lyase
Chain: A: PDB Molecule:cite;
PDBTitle: structure of cite complexed with triphosphate group of atp2 form mycobacterium tuberculosis
56d1liua2
not modelled 98.8 17 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
57c3cuzA_
not modelled 98.7 15 PDB header:transferase
Chain: A: PDB Molecule:malate synthase a;
PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design
58c3cuxA_
not modelled 98.2 17 PDB header:transferase
Chain: A: PDB Molecule:malate synthase;
PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design
59c3pugA_
not modelled 97.9 12 PDB header:transferase
Chain: A: PDB Molecule:malate synthase;
PDBTitle: haloferax volcanii malate synthase native at 3mm glyoxylate
60d1d8ca_
not modelled 97.0 13 Fold:TIM beta/alpha-barrel
Superfamily:Malate synthase G
Family:Malate synthase G
61c3e0vB_
not modelled 96.8 21 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of pyruvate kinase from leishmania mexicana in2 complex with sulphate ions
62c1aqfB_
not modelled 96.8 14 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: pyruvate kinase from rabbit muscle with mg, k, and l-2 phospholactate
63c2vgbB_
not modelled 96.7 15 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase isozymes r/l;
PDBTitle: human erythrocyte pyruvate kinase
64c1t5aB_
not modelled 96.7 14 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase, m2 isozyme;
PDBTitle: human pyruvate kinase m2
65c1pklB_
not modelled 96.7 17 PDB header:transferase
Chain: B: PDB Molecule:protein (pyruvate kinase);
PDBTitle: the structure of leishmania pyruvate kinase
66c3ma8A_
not modelled 96.5 12 PDB header:transferase
Chain: A: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of cgd1_2040, a pyruvate kinase from cryptosporidium2 parvum
67c3eoeC_
not modelled 96.5 16 PDB header:transferase
Chain: C: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of pyruvate kinase from toxoplasma gondii, 55.m00007
68c1e0tD_
not modelled 96.2 14 PDB header:phosphotransferase
Chain: D: PDB Molecule:pyruvate kinase;
PDBTitle: r292d mutant of e. coli pyruvate kinase
69c1a3wB_
not modelled 96.0 17 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: pyruvate kinase from saccharomyces cerevisiae complexed with fbp, pg,2 mn2+ and k+
70c3khdC_
not modelled 95.3 20 PDB header:transferase
Chain: C: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of pff1300w.
71c2zbtB_
not modelled 94.3 23 PDB header:lyase
Chain: B: PDB Molecule:pyridoxal biosynthesis lyase pdxs;
PDBTitle: crystal structure of pyridoxine biosynthesis protein from thermus2 thermophilus hb8
72c3femB_
not modelled 94.0 22 PDB header:biosynthetic protein, transferase
Chain: B: PDB Molecule:pyridoxine biosynthesis protein snz1;
PDBTitle: structure of the synthase subunit pdx1.1 (snz1) of plp synthase from2 saccharomyces cerevisiae
73c2nv2U_
not modelled 93.8 20 PDB header:lyase/transferase
Chain: U: PDB Molecule:pyridoxal biosynthesis lyase pdxs;
PDBTitle: structure of the plp synthase complex pdx1/2 (yaad/e) from bacillus2 subtilis
74d1eepa_
not modelled 92.1 21 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
75d2hi6a1
not modelled 89.8 14 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:LeuD/IlvD-like
Family:AF0055-like
76d1hl2a_
not modelled 87.7 24 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
77d1vrda1
not modelled 87.6 25 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
78d1jr1a1
not modelled 86.9 22 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
79c2v9dB_
not modelled 86.5 17 PDB header:lyase
Chain: B: PDB Molecule:yage;
PDBTitle: crystal structure of yage, a prophage protein belonging to2 the dihydrodipicolinic acid synthase family from e. coli3 k12
80d1pvna1
not modelled 86.0 17 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
81c3lerA_
not modelled 84.5 19 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from2 campylobacter jejuni subsp. jejuni nctc 11168
82c2vc6A_
not modelled 84.3 18 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: structure of mosa from s. meliloti with pyruvate bound
83c2a7rD_
not modelled 84.2 26 PDB header:oxidoreductase
Chain: D: PDB Molecule:gmp reductase 2;
PDBTitle: crystal structure of human guanosine monophosphate2 reductase 2 (gmpr2)
84d1o5ka_
not modelled 83.7 18 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
85c3cprB_
not modelled 83.7 20 PDB header:lyase
Chain: B: PDB Molecule:dihydrodipicolinate synthetase;
PDBTitle: the crystal structure of corynebacterium glutamicum2 dihydrodipicolinate synthase to 2.2 a resolution
86c3qjaA_
not modelled 83.7 12 PDB header:lyase
Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase;
PDBTitle: crystal structure of the mycobacterium tuberculosis indole-3-glycerol2 phosphate synthase (trpc) in apo form
87c1vrdA_
not modelled 83.2 25 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine-5'-monophosphate dehydrogenase;
PDBTitle: crystal structure of inosine-5'-monophosphate dehydrogenase (tm1347)2 from thermotoga maritima at 2.18 a resolution
88c3lciA_
not modelled 81.9 22 PDB header:lyase
Chain: A: PDB Molecule:n-acetylneuraminate lyase;
PDBTitle: the d-sialic acid aldolase mutant v251w
89c1jcnA_
not modelled 81.8 24 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine monophosphate dehydrogenase i;
PDBTitle: binary complex of human type-i inosine monophosphate dehydrogenase2 with 6-cl-imp
90c3khjE_
not modelled 80.8 25 PDB header:oxidoreductase
Chain: E: PDB Molecule:inosine-5-monophosphate dehydrogenase;
PDBTitle: c. parvum inosine monophosphate dehydrogenase bound by inhibitor c64
91c2ehhE_
not modelled 79.6 26 PDB header:lyase
Chain: E: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from2 aquifex aeolicus
92d1tb3a1
not modelled 79.5 22 Fold:TIM beta/alpha-barrel
Superfamily:FMN-linked oxidoreductases
Family:FMN-linked oxidoreductases
93d1zfja1
not modelled 79.1 21 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
94c2infB_
not modelled 79.1 18 PDB header:lyase
Chain: B: PDB Molecule:uroporphyrinogen decarboxylase;
PDBTitle: crystal structure of uroporphyrinogen decarboxylase from2 bacillus subtilis
95c3pueA_
not modelled 77.7 25 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of the complex of dhydrodipicolinate synthase from2 acinetobacter baumannii with lysine at 2.6a resolution
96d1n8ia_
not modelled 77.5 15 Fold:TIM beta/alpha-barrel
Superfamily:Malate synthase G
Family:Malate synthase G
97d1j93a_
not modelled 75.7 13 Fold:TIM beta/alpha-barrel
Superfamily:UROD/MetE-like
Family:Uroporphyrinogen decarboxylase, UROD
98c3r2gA_
not modelled 75.7 17 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine 5'-monophosphate dehydrogenase;
PDBTitle: crystal structure of inosine 5' monophosphate dehydrogenase from2 legionella pneumophila
99c3s5oA_
not modelled 74.8 10 PDB header:lyase
Chain: A: PDB Molecule:4-hydroxy-2-oxoglutarate aldolase, mitochondrial;
PDBTitle: crystal structure of human 4-hydroxy-2-oxoglutarate aldolase bound to2 pyruvate
100c2r8wB_
not modelled 74.6 22 PDB header:lyase
Chain: B: PDB Molecule:agr_c_1641p;
PDBTitle: the crystal structure of dihydrodipicolinate synthase (atu0899) from2 agrobacterium tumefaciens str. c58
101c3noeA_
not modelled 74.3 24 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from pseudomonas2 aeruginosa
102c3daqB_
not modelled 73.7 15 PDB header:lyase
Chain: B: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from methicillin-2 resistant staphylococcus aureus
103d1xxxa1
not modelled 73.1 20 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
104c2c3zA_
not modelled 72.6 21 PDB header:lyase
Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase;
PDBTitle: crystal structure of a truncated variant of indole-3-2 glycerol phosphate synthase from sulfolobus solfataricus
105d1a53a_
not modelled 72.1 12 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
106c1jpkA_
not modelled 70.6 14 PDB header:lyase
Chain: A: PDB Molecule:uroporphyrinogen decarboxylase;
PDBTitle: gly156asp mutant of human urod, human uroporphyrinogen iii2 decarboxylase
107d1jcna1
not modelled 70.2 22 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
108c2f7fA_
not modelled 69.4 22 PDB header:transferase
Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase, putative;
PDBTitle: crystal structure of enterococcus faecalis putative nicotinate2 phosphoribosyltransferase, new york structural genomics consortium
109c3n2xB_
not modelled 68.7 21 PDB header:lyase
Chain: B: PDB Molecule:uncharacterized protein yage;
PDBTitle: crystal structure of yage, a prophage protein belonging to the2 dihydrodipicolinic acid synthase family from e. coli k12 in complex3 with pyruvate
110d2a6na1
not modelled 68.6 20 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
111d2cu0a1
not modelled 67.5 22 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
112d2i14a1
not modelled 66.7 21 Fold:TIM beta/alpha-barrel
Superfamily:Nicotinate/Quinolinate PRTase C-terminal domain-like
Family:NadC C-terminal domain-like
113c2zrvC_
not modelled 66.4 25 PDB header:isomerase
Chain: C: PDB Molecule:isopentenyl-diphosphate delta-isomerase;
PDBTitle: crystal structure of sulfolobus shibatae isopentenyl2 diphosphate isomerase in complex with reduced fmn.
114c1me9A_
not modelled 65.3 18 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine-5'-monophosphate dehydrogenase;
PDBTitle: inosine monophosphate dehydrogenase (impdh) from2 tritrichomonas foetus with imp bound
115c3na8A_
not modelled 65.0 21 PDB header:lyase
Chain: A: PDB Molecule:putative dihydrodipicolinate synthetase;
PDBTitle: crystal structure of a putative dihydrodipicolinate synthetase from2 pseudomonas aeruginosa
116d1f74a_
not modelled 64.4 15 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
117c2hmcA_
not modelled 64.2 17 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: the crystal structure of dihydrodipicolinate synthase dapa from2 agrobacterium tumefaciens
118c1ypfB_
not modelled 63.6 21 PDB header:oxidoreductase
Chain: B: PDB Molecule:gmp reductase;
PDBTitle: crystal structure of guac (ba5705) from bacillus anthracis at 1.8 a2 resolution
119c2ejaB_
not modelled 63.5 15 PDB header:lyase
Chain: B: PDB Molecule:uroporphyrinogen decarboxylase;
PDBTitle: crystal structure of uroporphyrinogen decarboxylase from2 aquifex aeolicus
120c3g0sA_
not modelled 63.3 18 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: dihydrodipicolinate synthase from salmonella typhimurium lt2

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0