Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	Q	T	I	T	Q	S	R	L	R	I	D	A	N	F	K	R	F	V	D	E	E	V	L	P	G	T	G	L	D	A	A	A	F	W	R	N	F	D	E	I	V	H	D	L	A	P	E	N	R	Q	L	L	A	E	R	D	R	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																																?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	A	A	L	D	E	W	H	R	S	N	P	G	P	V	K	D	K	A	A	Y	K	S	F	L	R	E	L	G	Y	L	V	P	Q	P	E	R	V	T	V	E	T	T	G	I	D	S	E	I	T	S	Q	A	G	P	Q	L	V	V	P
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?	?																		?		?		?	?		?		?							?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	M	N	A	R	Y	A	L	N	A	A	N	A	R	W	G	S	L	Y	D	A	L	Y	G	S	D	I	I	P	Q	E	G	A	M	V	S	G	Y	D	P	Q	R	G	E	Q	V	I	A	W	V	R	R	F	L	D	E	S	L	P	L
Secondary structure
SS confidence
Disorder				?	?																									?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	N	G	S	Y	Q	D	V	V	A	F	K	V	V	D	K	Q	L	R	I	Q	L	K	N	G	K	E	T	T	L	R	T	P	A	Q	F	V	G	Y	R	G	D	A	A	A	P	T	C	I	L	L	K	N	N	G	L	H	I	E	L
Secondary structure
SS confidence
Disorder																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Q	I	D	A	N	G	R	I	G	K	D	D	P	A	H	I	N	D	V	I	V	E	A	A	I	S	T	I	L	D	C	E	D	S	V	A	A	V	D	A	E	D	K	I	L	L	Y	R	N	L	L	G	L	M	Q	G	T	L	Q	E
Secondary structure
SS confidence
Disorder					?	?	?	?	?		?	?		?											?	?	?	?	?		?	?	?		?					?			?	?	?	?	?	?													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		K	M	E	K	N	G	R	Q	I	V	R	K	L	N	D	D	R	H	Y	T	A	A	D	G	S	E	I	S	L	H	G	R	S	L	L	F	I	R	N	V	G	H	L	M	T	I	P	V	I	W	D	S	E	G	N	E	I	P	E	G
Secondary structure
SS confidence
Disorder														?		?			?	?	?			?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		I	L	D	G	V	M	T	G	A	I	A	L	Y	D	L	K	V	Q	K	N	S	R	T	G	S	V	Y	I	V	K	P	K	M	H	G	P	Q	E	V	A	F	A	N	K	L	F	T	R	I	E	T	M	L	G	M	A	P	N	T	L
Secondary structure
SS confidence
Disorder																			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		K	M	G	I	M	D	E	E	R	R	T	S	L	N	L	R	S	C	I	A	Q	A	R	N	R	V	A	F	I	N	T	G	F	L	D	R	T	G	D	E	M	H	S	V	M	E	A	G	P	M	L	R	K	N	Q	M	K	S	T	P
Secondary structure
SS confidence
Disorder												?																																			?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		W	I	K	A	Y	E	R	N	N	V	L	S	G	L	F	C	G	L	R	G	K	A	Q	I	G	K	G	M	W	A	M	P	D	L	M	A	D	M	Y	S	Q	K	G	D	Q	L	R	A	G	A	N	T	A	W	V	P	S	P	T	A
Secondary structure
SS confidence
Disorder																?	?	?	?		?	?	?	?	?	?	?	?	?	?																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		A	T	L	H	A	L	H	Y	H	Q	T	N	V	Q	S	V	Q	A	N	I	A	Q	T	E	F	N	A	E	F	E	P	L	L	D	D	L	L	T	I	P	V	A	E	N	A	N	W	S	A	Q	E	I	Q	Q	E	L	D	N	N	V
Secondary structure
SS confidence
Disorder															?	?	?	?	?		?		?	?	?	?		?									?		?			?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		Q	G	I	L	G	Y	V	V	R	W	V	E	Q	G	I	G	C	S	K	V	P	D	I	H	N	V	A	L	M	E	D	R	A	T	L	R	I	S	S	Q	H	I	A	N	W	L	R	H	G	I	L	T	K	E	Q	V	Q	A	S	L
Secondary structure
SS confidence
Disorder																								?	?	?																												?			?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence		E	N	M	A	K	V	V	D	Q	Q	N	A	G	D	P	A	Y	R	P	M	A	G	N	F	A	N	S	C	A	F	K	A	A	S	D	L	I	F	L	G	V	K	Q	P	N	G	Y	T	E	P	L	L	H	A	W	R	L	R	E	K
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.
Sequence		E	S	H
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1d8c chain A Region: 3 - 722 Aligned: 709 Modelled: 720 Confidence: 100.0% Identity: 97% Fold: TIM beta/alpha-barrel Superfamily: Malate synthase G Family: Malate synthase G Phyre2 PDB 1n8i chain A Region: 2 - 721 Aligned: 694 Modelled: 720 Confidence: 100.0% Identity: 60% Fold: TIM beta/alpha-barrel Superfamily: Malate synthase G Family: Malate synthase G Phyre2 PDB 3cuz chain A Region: 268 - 707 Aligned: 395 Modelled: 419 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:malate synthase a; PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design Phyre2 PDB 3cux chain A Region: 268 - 707 Aligned: 382 Modelled: 420 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:malate synthase; PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design Phyre2 PDB 3pug chain A Region: 268 - 680 Aligned: 280 Modelled: 299 Confidence: 99.8% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:malate synthase; PDBTitle: haloferax volcanii malate synthase native at 3mm glyoxylate Phyre2 PDB 3r4i chain B Region: 257 - 642 Aligned: 270 Modelled: 290 Confidence: 99.7% Identity: 16% PDB header:lyase Chain: B: PDB Molecule:citrate lyase; PDBTitle: crystal structure of a citrate lyase (bxe_b2899) from burkholderia2 xenovorans lb400 at 2.24 a resolution Phyre2 PDB 1sgj chain B Region: 387 - 548 Aligned: 138 Modelled: 162 Confidence: 99.6% Identity: 17% PDB header:lyase Chain: B: PDB Molecule:citrate lyase, beta subunit; PDBTitle: crystal structure of citrate lyase beta subunit Phyre2 PDB 3qqw chain C Region: 257 - 548 Aligned: 226 Modelled: 241 Confidence: 99.6% Identity: 13% PDB header:lyase Chain: C: PDB Molecule:putative citrate lyase; PDBTitle: crystal structure of a hypothetical lyase (reut_b4148) from ralstonia2 eutropha jmp134 at 2.44 a resolution Phyre2 PDB 1sgj chain A Region: 387 - 548 Aligned: 138 Modelled: 162 Confidence: 99.6% Identity: 17% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: HpcH/HpaI aldolase Phyre2 PDB 1u5v chain A Region: 268 - 548 Aligned: 190 Modelled: 216 Confidence: 99.6% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:cite; PDBTitle: structure of cite complexed with triphosphate group of atp2 form mycobacterium tuberculosis Phyre2 PDB 1u5h chain A Region: 268 - 548 Aligned: 190 Modelled: 216 Confidence: 99.6% Identity: 19% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: HpcH/HpaI aldolase Phyre2 PDB 2hro chain A Region: 370 - 501 Aligned: 124 Modelled: 132 Confidence: 97.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase; PDBTitle: structure of the full-lenght enzyme i of the pts system from2 staphylococcus carnosus Phyre2 PDB 2bg5 chain C Region: 370 - 501 Aligned: 124 Modelled: 132 Confidence: 96.8% Identity: 20% PDB header:transferase Chain: C: PDB Molecule:phosphoenolpyruvate-protein kinase; PDBTitle: crystal structure of the phosphoenolpyruvate-binding enzyme2 i-domain from the thermoanaerobacter tengcongensis pep:3 sugar phosphotransferase system (pts) Phyre2 PDB 1dxe chain A Region: 388 - 521 Aligned: 116 Modelled: 134 Confidence: 96.8% Identity: 14% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: HpcH/HpaI aldolase Phyre2 PDB 2hwg chain A Region: 370 - 501 Aligned: 124 Modelled: 132 Confidence: 96.5% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase; PDBTitle: structure of phosphorylated enzyme i of the2 phosphoenolpyruvate:sugar phosphotransferase system Phyre2 PDB 2v5j chain B Region: 388 - 521 Aligned: 116 Modelled: 134 Confidence: 96.0% Identity: 22% PDB header:lyase Chain: B: PDB Molecule:2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; PDBTitle: apo class ii aldolase hpch Phyre2 PDB 3qz6 chain A Region: 384 - 521 Aligned: 121 Modelled: 138 Confidence: 96.0% Identity: 13% PDB header:lyase Chain: A: PDB Molecule:hpch/hpai aldolase; PDBTitle: the crystal structure of hpch/hpai aldolase from desulfitobacterium2 hafniense dcb-2 Phyre2 PDB 2vwt chain A Region: 384 - 521 Aligned: 118 Modelled: 122 Confidence: 95.9% Identity: 17% PDB header:lyase Chain: A: PDB Molecule:yfau, 2-keto-3-deoxy sugar aldolase; PDBTitle: crystal structure of yfau, a metal ion dependent class ii2 aldolase from escherichia coli k12 - mg-pyruvate product3 complex Phyre2 PDB 2ols chain A Region: 375 - 501 Aligned: 109 Modelled: 111 Confidence: 93.4% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:phosphoenolpyruvate synthase; PDBTitle: the crystal structure of the phosphoenolpyruvate synthase from2 neisseria meningitidis Phyre2 PDB 1izc chain A Region: 384 - 521 Aligned: 125 Modelled: 138 Confidence: 93.1% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:macrophomate synthase intermolecular diels-alderase; PDBTitle: crystal structure analysis of macrophomate synthase Phyre2 1 d1d8ca_ 2 d1n8ia_ 3 c3cuzA_ 4 c3cuxA_ 5 c3pugA_ 6 c3r4iB_ 7 c1sgjB_ 8 c3qqwC_ 9 d1sgja_ 10 c1u5vA_ 11 d1u5ha_ 12 c2hroA_ 13 c2bg5C_ 14 d1dxea_ 15 c2hwgA_ 16 c2v5jB_ 17 c3qz6A_ 18 c2vwtA_ 19 c2olsA_ 20 c1izcA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99