Phyre 2 Results for P0A8T7

Email	l.a.kelley@imperial.ac.uk
Description	P0A8T7
Date	Wed Jan 25 15:20:19 GMT 2012
Unique Job ID	694a24a559587f5e

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c3iydD_

Top template information

PDB header:transcription/dna
Chain: D: PDB Molecule:dna-directed rna polymerase subunit beta;
PDBTitle: three-dimensional em structure of an intact activator-dependent2 transcription initiation complex

Confidence and coverage

Confidence:

100.0%

Coverage:

97%

1368 residues ( 97% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M K D L L K F L K A Q T K T E E F D A I K I A L A S P D M I R S W S F G E V K K P E T I N Y R T F K P E R D G L F C A R

Secondary structure

SS confidence

Disorder ? ? ? ?
? ? ? ? ? ? ? ? ? ? ?
? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence I F G P V K D Y E C L C G K Y K R L K H R G V I C E K C G V E V T Q T K V R R E R M G H I E L A S P T A H I W F L K S L

Secondary structure

SS confidence

Disorder
? ? ?
?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence P S R I G L L L D M P L R D I E R V L Y F E S Y V V I E G G M T N L E R Q Q I L T E E Q Y L D A L E E F G D E F D A K M

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence G A E A I Q A L L K S M D L E Q E C E Q L R E E L N E T N S E T K R K K L T K R I K L L E A F V Q S G N K P E W M I L T

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence V L P V L P P D L R P L V P L D G G R F A T S D L N D L Y R R V I N R N N R L K R L L D L A A P D I I V R N E K R M L Q

Secondary structure

SS confidence

Disorder
? ?
?
? ? ? ? ? ? ? ?
?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence E A V D A L L D N G R R G R A I T G S N K R P L K S L A D M I K G K Q G R F R Q N L L G K R V D Y S G R S V I T V G P Y

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence L R L H Q C G L P K K M A L E L F K P F I Y G K L E L R G L A T T I K A A K K M V E R E E A V V W D I L D E V I R E H P

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence V L L N R A P T L H R L G I Q A F E P V L I E G K A I Q L H P L V C A A Y N A D F D G D Q M A V H V P L T L E A Q L E A

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence R A L M M S T N N I L S P A N G E P I I V P S Q D V V L G L Y Y M T R D C V N A K G E G M V L T G P K E A E R L Y R S G

Secondary structure

SS confidence

Disorder
?
?
? ?
? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence L A S L H A R V K V R I T E Y E K D A N G E L V A K T S L K D T T V G R A I L W M I V P K G L P Y S I V N Q A L G K K A

Secondary structure

SS confidence

Disorder ? ? ?
? ? ? ? ? ?
?
? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence I S K M L N T C Y R I L G L K P T V I F A D Q I M Y T G F A Y A A R S G A S V G I D D M V I P E K K H E I I S E A E A E

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence V A E I Q E Q F Q S G L V T A G E R Y N K V I D I W A A A N D R V S K A M M D N L Q T E T V I N R D G Q E E K Q V S F N

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence S I Y M M A D S G A R G S A A Q I R Q L A G M R G L M A K P D G S I I E T P I T A N F R E G L N V L Q Y F I S T H G A R

Secondary structure

SS confidence

Disorder ?
? ? ?
? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence K G L A D T A L K T A N S G Y L T R R L V D V A Q D L V V T E D D C G T H E G I M M T P V I E G G D V K E P L R D R V L

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence G R V T A E D V L K P G T A D I L V P R N T L L H E Q W C D L L E E N S V D A V K V R S V V S C D T D F G V C A H C Y G

Secondary structure

SS confidence

Disorder
?
?
? ?
? ?
? ? ? ?
?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence R D L A R G H I I N K G E A I G V I A A Q S I G E P G T Q L T M R T F H I G G A A S R A A A E S S I Q V K N K G S I K L

Secondary structure

SS confidence

Disorder ? ? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence S N V K S V V N S S G K L V I T S R N T E L K L I D E F G R T K E S Y K V P Y G A V L A K G D G E Q V A G G E T V A N W

Secondary structure

SS confidence

Disorder
?
?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence D P H T M P V I T E V S G F V R F T D M I D G Q T I T R Q T D E L T G L S S L V V L D S A E R T A G G K D L R P A L K I

Secondary structure

SS confidence

Disorder
?
?
?
? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence V D A Q G N D V L I P G T D M P A Q Y F L P G K A I V Q L E D G V Q I S S G D T L A R I P Q E S G G T K D I T G G L P R

Secondary structure

SS confidence

Disorder
? ?
? ? ? ? ? ? ?
? ?
? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence V A D L F E A R R P K E P A I L A E I S G I V S F G K E T K G K R R L V I T P V D G S D P Y E E M I P K W R Q L N V F E

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence G E R V E R G D V I S D G P E A P H D I L R L R G V H A V T R Y I V N E V Q D V Y R L Q G V K I N D K H I E V I V R Q M

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence L R K A T I V N A G S S D F L E G E Q V E Y S R V K I A N R E L E A N G K V G A T Y S R D L L G I T K A S L A T E S F I

Secondary structure

SS confidence

Disorder ?
? ? ? ? ?
? ? ? ?
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . . . . 1380

Sequence S A A S F Q E T T R V L T E A A V A G K R D E L R G L K E N V I V G R L I P A G T G Y A Y H Q D R M R R R A A G E A P A

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1390 . . . . . . . . . 1400 . . . . . . .

Sequence A P Q V T A E D A S A S L A E L L N A G L G G S D N E

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3iyd chain D

Region: 15 - 1382
Aligned: 1368
Modelled: 1368
Confidence: 100.0%
Identity: 100%
PDB header:transcription/dna
Chain: D: PDB Molecule:dna-directed rna polymerase subunit beta;
PDBTitle: three-dimensional em structure of an intact activator-dependent2 transcription initiation complex

Phyre2

PDB 3h0g chain A

Region: 6 - 1407
Aligned: 1279
Modelled: 1313
Confidence: 100.0%
Identity: 24%
PDB header:transcription
Chain: A: PDB Molecule:dna-directed rna polymerase ii subunit rpb1;
PDBTitle: rna polymerase ii from schizosaccharomyces pombe

Phyre2

PDB 1twf chain A

Region: 9 - 1366
Aligned: 1215
Modelled: 1259
Confidence: 100.0%
Identity: 24%
Fold: beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily: beta and beta-prime subunits of DNA dependent RNA-polymerase
Family: RNA-polymerase beta-prime

Phyre2

PDB 1smy chain D

Region: 15 - 1387
Aligned: 1159
Modelled: 1172
Confidence: 100.0%
Identity: 52%
Fold: beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily: beta and beta-prime subunits of DNA dependent RNA-polymerase
Family: RNA-polymerase beta-prime

Phyre2

PDB 1i6h chain A

Region: 9 - 1366
Aligned: 1202
Modelled: 1259
Confidence: 100.0%
Identity: 24%
PDB header:transcription/dna-rna hybrid
Chain: A: PDB Molecule:dna-directed rna polymerase ii largest subunit;
PDBTitle: rna polymerase ii elongation complex

Phyre2

PDB 1i6v chain D

Region: 15 - 1366
Aligned: 1083
Modelled: 1126
Confidence: 100.0%
Identity: 51%
Fold: beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily: beta and beta-prime subunits of DNA dependent RNA-polymerase
Family: RNA-polymerase beta-prime

Phyre2

PDB 1i6v chain D

Region: 15 - 1366
Aligned: 1083
Modelled: 1126
Confidence: 100.0%
Identity: 51%
PDB header:transcription
Chain: D: PDB Molecule:dna-directed rna polymerase;
PDBTitle: thermus aquaticus core rna polymerase-rifampicin complex

Phyre2

PDB 1ynj chain D domain 1

Region: 15 - 934
Aligned: 902
Modelled: 908
Confidence: 100.0%
Identity: 58%
Fold: beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily: beta and beta-prime subunits of DNA dependent RNA-polymerase
Family: RNA-polymerase beta-prime

Phyre2

PDB 2pmz chain Q

Region: 15 - 836
Aligned: 685
Modelled: 715
Confidence: 100.0%
Identity: 31%
PDB header:translation, transferase
Chain: Q: PDB Molecule:dna-directed rna polymerase subunit a;
PDBTitle: archaeal rna polymerase from sulfolobus solfataricus

Phyre2

PDB 3qqc chain A

Region: 9 - 335
Aligned: 295
Modelled: 312
Confidence: 100.0%
Identity: 26%
PDB header:transcription
Chain: A: PDB Molecule:dna-directed rna polymerase subunit b, dna-directed rna
PDBTitle: crystal structure of archaeal spt4/5 bound to the rnap clamp domain

Phyre2

PDB 2pmz chain G

Region: 851 - 1373
Aligned: 277
Modelled: 282
Confidence: 100.0%
Identity: 27%
PDB header:translation, transferase
Chain: G: PDB Molecule:dna-directed rna polymerase subunit a";
PDBTitle: archaeal rna polymerase from sulfolobus solfataricus

Phyre2

PDB 2auk chain A

Region: 941 - 1128
Aligned: 188
Modelled: 188
Confidence: 98.0%
Identity: 98%
PDB header:transferase
Chain: A: PDB Molecule:dna-directed rna polymerase beta' chain;
PDBTitle: structure of e. coli rna polymerase beta' g/g' insert

Phyre2

PDB 2auj chain D

Region: 992 - 1220
Aligned: 222
Modelled: 228
Confidence: 97.7%
Identity: 21%
PDB header:transferase
Chain: D: PDB Molecule:dna-directed rna polymerase beta' chain;
PDBTitle: structure of thermus aquaticus rna polymerase beta'-subunit2 insert

Phyre2

PDB 3e7h chain A

Region: 785 - 875
Aligned: 90
Modelled: 91
Confidence: 96.2%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:dna-directed rna polymerase subunit beta;
PDBTitle: the crystal structure of the beta subunit of the dna-2 directed rna polymerase from vibrio cholerae o1 biovar3 eltor

Phyre2

PDB 2j7n chain A

Region: 416 - 468
Aligned: 51
Modelled: 53
Confidence: 89.8%
Identity: 27%
PDB header:hydrolase
Chain: A: PDB Molecule:rna-dependent rna polymerase;
PDBTitle: structure of the rnai polymerase from neurospora crassa

Phyre2

PDB 3ky9 chain B

Region: 18 - 103
Aligned: 81
Modelled: 86
Confidence: 62.5%
Identity: 12%
PDB header:apoptosis
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: autoinhibited vav1

Phyre2

PDB 1nvm chain B domain 2

Region: 901 - 984
Aligned: 72
Modelled: 84
Confidence: 56.4%
Identity: 15%
Fold: FwdE/GAPDH domain-like
Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
Family: GAPDH-like

Phyre2

PDB 2f9y chain B domain 1

Region: 84 - 102
Aligned: 19
Modelled: 19
Confidence: 48.4%
Identity: 21%
Fold: ClpP/crotonase
Superfamily: ClpP/crotonase
Family: Biotin dependent carboxylase carboxyltransferase domain

Phyre2

PDB 2f9y chain B

Region: 84 - 102
Aligned: 19
Modelled: 19
Confidence: 48.4%
Identity: 21%
PDB header:ligase
Chain: B: PDB Molecule:acetyl-coenzyme a carboxylase carboxyl transferase subunit
PDBTitle: the crystal structure of the carboxyltransferase subunit of acc from2 escherichia coli

Phyre2

PDB 1nvm chain B

Region: 901 - 984
Aligned: 72
Modelled: 84
Confidence: 47.0%
Identity: 15%
PDB header:lyase/oxidoreductase
Chain: B: PDB Molecule:acetaldehyde dehydrogenase (acylating);
PDBTitle: crystal structure of a bifunctional aldolase-dehydrogenase :2 sequestering a reactive and volatile intermediate

Phyre2

Detailed template information

#	Template	Alignment Coverage	3D Model	Confidence	% i.d.	Template Information

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server

Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]

If you use the binding site predictions from 3DLigandSite, please also cite:

3DLigandSite: predicting ligand-binding sites using similar structures.

Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]

Imperial College London

Lawrence Kelley, Benjamin Jefferys

Disclaimer

Terms and Conditions

Component software

Template detection: HHpred 1.51

Secondary structure prediction: Psi-pred 2.5

Disorder prediction: Disopred 2.4

Transmembrane prediction: Memsat_SVM

Multi-template modelling and ab initio: Poing 1.0

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	K	D	L	L	K	F	L	K	A	Q	T	K	T	E	E	F	D	A	I	K	I	A	L	A	S	P	D	M	I	R	S	W	S	F	G	E	V	K	K	P	E	T	I	N	Y	R	T	F	K	P	E	R	D	G	L	F	C	A	R
Secondary structure
SS confidence
Disorder	?	?	?	?			?	?	?	?	?	?	?	?	?	?	?																														?	?			?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	I	F	G	P	V	K	D	Y	E	C	L	C	G	K	Y	K	R	L	K	H	R	G	V	I	C	E	K	C	G	V	E	V	T	Q	T	K	V	R	R	E	R	M	G	H	I	E	L	A	S	P	T	A	H	I	W	F	L	K	S	L
Secondary structure
SS confidence
Disorder																			?	?	?														?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	P	S	R	I	G	L	L	L	D	M	P	L	R	D	I	E	R	V	L	Y	F	E	S	Y	V	V	I	E	G	G	M	T	N	L	E	R	Q	Q	I	L	T	E	E	Q	Y	L	D	A	L	E	E	F	G	D	E	F	D	A	K	M
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	G	A	E	A	I	Q	A	L	L	K	S	M	D	L	E	Q	E	C	E	Q	L	R	E	E	L	N	E	T	N	S	E	T	K	R	K	K	L	T	K	R	I	K	L	L	E	A	F	V	Q	S	G	N	K	P	E	W	M	I	L	T
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	V	L	P	V	L	P	P	D	L	R	P	L	V	P	L	D	G	G	R	F	A	T	S	D	L	N	D	L	Y	R	R	V	I	N	R	N	N	R	L	K	R	L	L	D	L	A	A	P	D	I	I	V	R	N	E	K	R	M	L	Q
Secondary structure
SS confidence
Disorder								?	?				?		?	?	?	?	?	?	?	?		?																				?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	E	A	V	D	A	L	L	D	N	G	R	R	G	R	A	I	T	G	S	N	K	R	P	L	K	S	L	A	D	M	I	K	G	K	Q	G	R	F	R	Q	N	L	L	G	K	R	V	D	Y	S	G	R	S	V	I	T	V	G	P	Y
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	L	R	L	H	Q	C	G	L	P	K	K	M	A	L	E	L	F	K	P	F	I	Y	G	K	L	E	L	R	G	L	A	T	T	I	K	A	A	K	K	M	V	E	R	E	E	A	V	V	W	D	I	L	D	E	V	I	R	E	H	P
Secondary structure
SS confidence
Disorder																																													?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	V	L	L	N	R	A	P	T	L	H	R	L	G	I	Q	A	F	E	P	V	L	I	E	G	K	A	I	Q	L	H	P	L	V	C	A	A	Y	N	A	D	F	D	G	D	Q	M	A	V	H	V	P	L	T	L	E	A	Q	L	E	A
Secondary structure
SS confidence
Disorder																																						?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	R	A	L	M	M	S	T	N	N	I	L	S	P	A	N	G	E	P	I	I	V	P	S	Q	D	V	V	L	G	L	Y	Y	M	T	R	D	C	V	N	A	K	G	E	G	M	V	L	T	G	P	K	E	A	E	R	L	Y	R	S	G
Secondary structure
SS confidence
Disorder							?																?														?	?																					?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	L	A	S	L	H	A	R	V	K	V	R	I	T	E	Y	E	K	D	A	N	G	E	L	V	A	K	T	S	L	K	D	T	T	V	G	R	A	I	L	W	M	I	V	P	K	G	L	P	Y	S	I	V	N	Q	A	L	G	K	K	A
Secondary structure
SS confidence
Disorder	?	?	?												?	?	?	?	?	?		?			?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	I	S	K	M	L	N	T	C	Y	R	I	L	G	L	K	P	T	V	I	F	A	D	Q	I	M	Y	T	G	F	A	Y	A	A	R	S	G	A	S	V	G	I	D	D	M	V	I	P	E	K	K	H	E	I	I	S	E	A	E	A	E
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	V	A	E	I	Q	E	Q	F	Q	S	G	L	V	T	A	G	E	R	Y	N	K	V	I	D	I	W	A	A	A	N	D	R	V	S	K	A	M	M	D	N	L	Q	T	E	T	V	I	N	R	D	G	Q	E	E	K	Q	V	S	F	N
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?																									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	S	I	Y	M	M	A	D	S	G	A	R	G	S	A	A	Q	I	R	Q	L	A	G	M	R	G	L	M	A	K	P	D	G	S	I	I	E	T	P	I	T	A	N	F	R	E	G	L	N	V	L	Q	Y	F	I	S	T	H	G	A	R
Secondary structure
SS confidence
Disorder	?						?	?	?																					?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	K	G	L	A	D	T	A	L	K	T	A	N	S	G	Y	L	T	R	R	L	V	D	V	A	Q	D	L	V	V	T	E	D	D	C	G	T	H	E	G	I	M	M	T	P	V	I	E	G	G	D	V	K	E	P	L	R	D	R	V	L
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	G	R	V	T	A	E	D	V	L	K	P	G	T	A	D	I	L	V	P	R	N	T	L	L	H	E	Q	W	C	D	L	L	E	E	N	S	V	D	A	V	K	V	R	S	V	V	S	C	D	T	D	F	G	V	C	A	H	C	Y	G
Secondary structure
SS confidence
Disorder										?																									?			?	?			?	?				?	?	?	?										?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	R	D	L	A	R	G	H	I	I	N	K	G	E	A	I	G	V	I	A	A	Q	S	I	G	E	P	G	T	Q	L	T	M	R	T	F	H	I	G	G	A	A	S	R	A	A	A	E	S	S	I	Q	V	K	N	K	G	S	I	K	L
Secondary structure
SS confidence
Disorder	?	?	?																																							?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	S	N	V	K	S	V	V	N	S	S	G	K	L	V	I	T	S	R	N	T	E	L	K	L	I	D	E	F	G	R	T	K	E	S	Y	K	V	P	Y	G	A	V	L	A	K	G	D	G	E	Q	V	A	G	G	E	T	V	A	N	W
Secondary structure
SS confidence
Disorder											?																		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	D	P	H	T	M	P	V	I	T	E	V	S	G	F	V	R	F	T	D	M	I	D	G	Q	T	I	T	R	Q	T	D	E	L	T	G	L	S	S	L	V	V	L	D	S	A	E	R	T	A	G	G	K	D	L	R	P	A	L	K	I
Secondary structure
SS confidence
Disorder																					?												?					?						?	?	?	?	?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	V	D	A	Q	G	N	D	V	L	I	P	G	T	D	M	P	A	Q	Y	F	L	P	G	K	A	I	V	Q	L	E	D	G	V	Q	I	S	S	G	D	T	L	A	R	I	P	Q	E	S	G	G	T	K	D	I	T	G	G	L	P	R
Secondary structure
SS confidence
Disorder															?	?														?	?	?	?	?	?	?		?	?							?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	V	A	D	L	F	E	A	R	R	P	K	E	P	A	I	L	A	E	I	S	G	I	V	S	F	G	K	E	T	K	G	K	R	R	L	V	I	T	P	V	D	G	S	D	P	Y	E	E	M	I	P	K	W	R	Q	L	N	V	F	E
Secondary structure
SS confidence
Disorder										?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	G	E	R	V	E	R	G	D	V	I	S	D	G	P	E	A	P	H	D	I	L	R	L	R	G	V	H	A	V	T	R	Y	I	V	N	E	V	Q	D	V	Y	R	L	Q	G	V	K	I	N	D	K	H	I	E	V	I	V	R	Q	M
Secondary structure
SS confidence
Disorder																																																												?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	L	R	K	A	T	I	V	N	A	G	S	S	D	F	L	E	G	E	Q	V	E	Y	S	R	V	K	I	A	N	R	E	L	E	A	N	G	K	V	G	A	T	Y	S	R	D	L	L	G	I	T	K	A	S	L	A	T	E	S	F	I
Secondary structure
SS confidence
Disorder	?																																		?	?	?	?	?		?	?	?	?						?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350	.	.	.	.	.	.	.	.	.	1360	.	.	.	.	.	.	.	.	.	1370	.	.	.	.	.	.	.	.	.	1380
Sequence	S	A	A	S	F	Q	E	T	T	R	V	L	T	E	A	A	V	A	G	K	R	D	E	L	R	G	L	K	E	N	V	I	V	G	R	L	I	P	A	G	T	G	Y	A	Y	H	Q	D	R	M	R	R	R	A	A	G	E	A	P	A
Secondary structure
SS confidence
Disorder																																			?																?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1390	.	.	.	.	.	.	.	.	.	1400	.	.	.	.	.	.	.
Sequence	A	P	Q	V	T	A	E	D	A	S	A	S	L	A	E	L	L	N	A	G	L	G	G	S	D	N	E
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?					?	?	?	?	?	?	?	?	?	?
Disorder confidence