Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	F	S	R	F	I	I	G	L	T	S	C	I	A	F	S	V	Q	A	A	N	V	D	E	Y	I	T	Q	L	P	A	G	A	N	L	A	L	M	V	Q	K	V	G	A	S	A	P	A	I	D	Y	H	S	Q	Q	M	A	L	P
Secondary structure
SS confidence
Disorder		?	?	?												?	?	?	?	?	?	?	?	?	?				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	S	T	Q	K	V	I	T	A	L	A	A	L	I	Q	L	G	P	D	F	R	F	T	T	T	L	E	T	K	G	N	V	E	N	G	V	L	K	G	D	L	V	A	R	F	G	A	D	P	T	L	K	R	Q	D	I	R	N	M	V
Secondary structure
SS confidence
Disorder																														?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	T	L	K	K	S	G	V	N	Q	I	D	G	N	V	L	I	D	T	S	I	F	A	S	H	D	K	A	P	G	W	P	W	N	D	M	T	Q	C	F	S	A	P	P	A	A	A	I	V	D	R	N	C	F	S	V	S	L	Y	S
Secondary structure
SS confidence
Disorder																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	P	K	P	G	D	M	A	F	I	R	V	A	S	Y	Y	P	V	T	M	F	S	Q	V	R	T	L	P	R	G	S	A	E	A	Q	Y	C	E	L	D	V	V	P	G	D	L	N	R	F	T	L	T	G	C	L	P	Q	R	S	E
Secondary structure
SS confidence
Disorder		?														?	?						?				?	?	?														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	L	P	L	A	F	A	V	Q	D	G	A	S	Y	A	G	A	I	L	K	D	E	L	K	Q	A	G	I	T	W	S	G	T	L	L	R	Q	T	Q	V	N	E	P	G	T	V	V	A	S	K	Q	S	A	P	L	H	D	L	L	K
Secondary structure
SS confidence
Disorder																																	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		I	M	L	K	K	S	D	N	M	I	A	D	T	V	F	R	M	I	G	H	A	R	F	N	V	P	G	T	W	R	A	G	S	D	A	V	R	Q	I	L	R	Q	Q	A	G	V	D	I	G	N	T	I	I	A	D	G	S	G	L	S
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	H	N	L	I	A	P	A	T	M	M	Q	V	L	Q	Y	I	A	Q	H	D	N	E	L	N	F	I	S	M	L	P	L	A	G	Y	D	G	S	L	Q	Y	R	A	G	L	H	Q	A	G	V	D	G	K	V	S	A	K	T	G	S
Secondary structure
SS confidence
Disorder																															?		?	?	?											?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.
Sequence		L	Q	G	V	Y	N	L	A	G	F	I	T	T	A	S	G	Q	R	M	A	F	V	Q	Y	L	S	G	Y	A	V	E	P	A	D	Q	R	N	R	R	I	P	L	V	R	F	E	S	R	L	Y	K	D	I	Y	Q	N	N
Secondary structure
SS confidence
Disorder																														?	?	?																								?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2ex2 chain A domain 1 Region: 22 - 477 Aligned: 456 Modelled: 456 Confidence: 100.0% Identity: 100% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: Dac-like Phyre2 PDB 1w5d chain A domain 1 Region: 18 - 465 Aligned: 439 Modelled: 448 Confidence: 100.0% Identity: 28% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: Dac-like Phyre2 PDB 1w79 chain A domain 1 Region: 21 - 472 Aligned: 439 Modelled: 452 Confidence: 100.0% Identity: 28% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: Dac-like Phyre2 PDB 3a3e chain B Region: 22 - 476 Aligned: 431 Modelled: 440 Confidence: 100.0% Identity: 42% PDB header:hydrolase Chain: B: PDB Molecule:penicillin-binding protein 4; PDBTitle: crystal structure of penicillin binding protein 4 (dacb)2 from haemophilus influenzae, complexed with novel beta-3 lactam (cmv) Phyre2 PDB 2j7v chain A Region: 14 - 473 Aligned: 258 Modelled: 265 Confidence: 99.9% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:tll2115 protein; PDBTitle: structure of pbp-a Phyre2 PDB 3qhy chain A Region: 33 - 473 Aligned: 238 Modelled: 243 Confidence: 99.9% Identity: 16% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:beta-lactamase; PDBTitle: structural, thermodynamic and kinetic analysis of the picomolar2 binding affinity interaction of the beta-lactamase inhibitor protein-3 ii (blip-ii) with class a beta-lactamases Phyre2 PDB 3cg5 chain A Region: 22 - 473 Aligned: 255 Modelled: 267 Confidence: 99.9% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of the covalent adduct formed between tb2 b-lactamase and clavulanate Phyre2 PDB 2v20 chain A Region: 24 - 473 Aligned: 250 Modelled: 254 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase tem; PDBTitle: structure of a tem-1 beta-lactamase insertant2 allosterically regulated by kanamycin and anions. complex3 with sulfate. Phyre2 PDB 1hzo chain A Region: 23 - 476 Aligned: 253 Modelled: 258 Confidence: 99.9% Identity: 21% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 1n9b chain A Region: 17 - 475 Aligned: 257 Modelled: 263 Confidence: 99.9% Identity: 19% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 2cc1 chain A domain 1 Region: 21 - 474 Aligned: 254 Modelled: 258 Confidence: 99.9% Identity: 21% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 2ov5 chain A Region: 20 - 473 Aligned: 251 Modelled: 258 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:carbapenemase; PDBTitle: crystal structure of the kpc-2 carbapenemase Phyre2 PDB 1w7f chain B Region: 33 - 473 Aligned: 238 Modelled: 243 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of the class a beta-lactamase bs32 inhibited with isocitrate Phyre2 PDB 3dw0 chain B Region: 33 - 477 Aligned: 244 Modelled: 249 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:class a carbapenemase kpc-2; PDBTitle: crystal structure of the class a carbapenemase kpc-2 at 1.62 angstrom resolution Phyre2 PDB 1bsg chain A Region: 21 - 473 Aligned: 256 Modelled: 261 Confidence: 99.9% Identity: 20% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 1dy6 chain A Region: 18 - 473 Aligned: 254 Modelled: 272 Confidence: 99.9% Identity: 16% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 1m40 chain A Region: 22 - 473 Aligned: 250 Modelled: 256 Confidence: 99.9% Identity: 19% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 1i2s chain A Region: 21 - 473 Aligned: 248 Modelled: 255 Confidence: 99.9% Identity: 22% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 1i2s chain A Region: 21 - 473 Aligned: 248 Modelled: 255 Confidence: 99.9% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: beta-lactamase from bacillus licheniformis bs3 Phyre2 PDB 2wuq chain A Region: 19 - 475 Aligned: 259 Modelled: 262 Confidence: 99.9% Identity: 22% PDB header:transcription Chain: A: PDB Molecule:beta-lactamase regulatory protein blab; PDBTitle: crystal structure of blab protein from streptomyces cacaoi Phyre2 PDB 3hle chain A Region: 7 - 75 Aligned: 68 Modelled: 68 Confidence: 93.8% Identity: 10% PDB header:transferase Chain: A: PDB Molecule:transesterase; PDBTitle: simvastatin synthase (lovd), from aspergillus terreus, s5 mutant, s76a2 mutant, complex with monacolin j acid Phyre2 1 d2ex2a1 2 d1w5da1 3 d1w79a1 4 c3a3eB_ 5 c2j7vA_ 6 c3qhyA_ 7 c3cg5A_ 8 c2v20A_ 9 d1hzoa_ 10 d1n9ba_ 11 d2cc1a1 12 c2ov5A_ 13 c1w7fB_ 14 c3dw0B_ 15 d1bsga_ 16 d1dy6a_ 17 d1m40a_ 18 d1i2sa_ 19 c1i2sA_ 20 c2wuqA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 c3hleA_ 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2ex2a1 100.0 100 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:Dac-like 2 d1w5da1 100.0 28 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:Dac-like 3 d1w79a1 100.0 28 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:Dac-like 4 c3a3eB_ 100.0 42 PDB header:hydrolase Chain: B: PDB Molecule:penicillin-binding protein 4; PDBTitle: crystal structure of penicillin binding protein 4 (dacb)2 from haemophilus influenzae, complexed with novel beta-3 lactam (cmv) 5 c2j7vA_ 99.9 19 PDB header:hydrolase Chain: A: PDB Molecule:tll2115 protein; PDBTitle: structure of pbp-a 6 c3qhyA_ 99.9 16 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:beta-lactamase; PDBTitle: structural, thermodynamic and kinetic analysis of the picomolar2 binding affinity interaction of the beta-lactamase inhibitor protein-3 ii (blip-ii) with class a beta-lactamases 7 c3cg5A_ 99.9 21 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of the covalent adduct formed between tb2 b-lactamase and clavulanate 8 c2v20A_ 99.9 16 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase tem; PDBTitle: structure of a tem-1 beta-lactamase insertant2 allosterically regulated by kanamycin and anions. complex3 with sulfate. 9 d1hzoa_ 99.9 21 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 10 d1n9ba_ 99.9 19 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 11 d2cc1a1 99.9 21 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 12 c2ov5A_ 99.9 20 PDB header:hydrolase Chain: A: PDB Molecule:carbapenemase; PDBTitle: crystal structure of the kpc-2 carbapenemase 13 c1w7fB_ 99.9 18 PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of the class a beta-lactamase bs32 inhibited with isocitrate 14 c3dw0B_ 99.9 20 PDB header:hydrolase Chain: B: PDB Molecule:class a carbapenemase kpc-2; PDBTitle: crystal structure of the class a carbapenemase kpc-2 at 1.62 angstrom resolution 15 d1bsga_ 99.9 20 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 16 d1dy6a_ 99.9 16 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 17 d1m40a_ 99.9 19 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 18 d1i2sa_ 99.9 22 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 19 c1i2sA_ 99.9 22 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: beta-lactamase from bacillus licheniformis bs3 20 c2wuqA_ 99.9 22 PDB header:transcription Chain: A: PDB Molecule:beta-lactamase regulatory protein blab; PDBTitle: crystal structure of blab protein from streptomyces cacaoi 21 c3cjmA_ not modelled 99.9 19 PDB header:hydrolase Chain: A: PDB Molecule:putative beta-lactamase; PDBTitle: crystal structure of putative beta-lactamase (np_815223.1) from2 enterococcus faecalis v583 at 1.50 a resolution 22 d1buea_ not modelled 99.9 18 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 23 d1g6aa_ not modelled 99.9 21 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 24 c2wuqB_ not modelled 99.9 21 PDB header:transcription Chain: B: PDB Molecule:beta-lactamase regulatory protein blab; PDBTitle: crystal structure of blab protein from streptomyces cacaoi 25 c3lezA_ not modelled 99.9 20 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of a halotolerant bacterial beta-lactamase 26 d1e25a_ not modelled 99.9 20 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 27 d1o7ea_ not modelled 99.9 22 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 28 d1iysa_ not modelled 99.9 20 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 29 c2qpnA_ not modelled 99.9 17 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase ges-1; PDBTitle: ges-1 beta-lactamase 30 d1xp4a2 not modelled 99.9 27 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 31 c3p09B_ not modelled 99.9 20 PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of beta-lactamase from francisella tularensis 32 d1djaa_ not modelled 99.9 18 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 33 d3beca2 not modelled 99.8 22 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 34 c3p09A_ not modelled 99.8 21 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of beta-lactamase from francisella tularensis 35 d1alqa_ not modelled 99.8 20 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 36 d1es5a_ not modelled 99.8 16 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 37 c2bcfA_ not modelled 99.8 21 PDB header:hydrolase Chain: A: PDB Molecule:probable d-alanyl-d-alanine carboxypeptidase PDBTitle: crystal structure of a evolved putative penicillin-binding2 protein homolog, rv2911, from mycobacterium tuberculosis. 38 d1tvfa2 not modelled 99.8 18 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 39 c3a3jA_ not modelled 99.8 21 PDB header:hydrolase Chain: A: PDB Molecule:pbp5; PDBTitle: crystal structures of penicillin binding protein 5 from2 haemophilus influenzae 40 c1z6fA_ not modelled 99.8 19 PDB header:hydrolase Chain: A: PDB Molecule:penicillin-binding protein 5; PDBTitle: crystal structure of penicillin-binding protein 5 from e. coli in2 complex with a boronic acid inhibitor 41 c3it9B_ not modelled 99.8 20 PDB header:hydrolase Chain: B: PDB Molecule:d-alanyl-d-alanine carboxypeptidase dacc; PDBTitle: crystal structure of penicillin-binding protein 6 (pbp6)2 from e. coli in apo state 42 c3humB_ not modelled 99.8 23 PDB header:hydrolase/antibiotics Chain: B: PDB Molecule:penicillin-binding protein 4; PDBTitle: crystal structure of penicillin binding protein 4 from2 staphylococcus aureus col in complex with cefotaxime 43 c3mfdB_ not modelled 99.7 22 PDB header:hydrolase Chain: B: PDB Molecule:d-alanyl-d-alanine carboxypeptidase dacb; PDBTitle: the structure of the beta-lactamase superfamily domain of d-alanyl-d-2 alanine carboxypeptidase from bacillus subtilis 44 c1tvfA_ not modelled 99.7 21 PDB header:penicillin binding Chain: A: PDB Molecule:penicillin binding protein 4; PDBTitle: crystal structure of penicillin-binding protein 4 (pbp4)2 from staphylococcus aureus 45 c1xp4C_ not modelled 99.7 25 PDB header:hydrolase Chain: C: PDB Molecule:d-alanyl-d-alanine carboxypeptidase; PDBTitle: crystal structure of a peptidoglycan synthesis regulatory2 factor (pbp3) from streptococcus pneumoniae 46 c2xftA_ not modelled 99.6 24 PDB header:hydrolase Chain: A: PDB Molecule:orf12; PDBTitle: structural and mechanistic studies on a cephalosporin esterase from2 the clavulanic acid biosynthesis pathway 47 c2jc7A_ not modelled 99.4 19 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase oxa-24; PDBTitle: the crystal structure of the carbapenemase oxa-24 reveals2 new insights into the mechanism of carbapenem-hydrolysis 48 d1nrfa_ not modelled 99.2 21 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 49 d1vqqa3 not modelled 98.8 21 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 50 d1k38a_ not modelled 98.5 13 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 51 c3hbrD_ not modelled 98.5 13 PDB header:hydrolase Chain: D: PDB Molecule:oxa-48; PDBTitle: crystal structure of oxa-48 beta-lactamase 52 d1xa1a_ not modelled 98.4 16 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 53 c3if6C_ not modelled 98.4 18 PDB header:hydrolase Chain: C: PDB Molecule:oxa-46 oxacillinase; PDBTitle: crystal structure of oxa-46 beta-lactamase from p.2 aeruginosa 54 d1m6ka_ not modelled 98.2 21 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 55 d1k55a_ not modelled 98.2 14 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 56 d1pyya4 not modelled 98.1 19 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 57 c2iwdA_ not modelled 98.0 15 PDB header:antibiotic resistance Chain: A: PDB Molecule:methicillin resistance mecr1 protein; PDBTitle: oxacilloyl-acylated mecr1 extracellular antibiotic-sensor2 domain. 58 c3lo7A_ not modelled 98.0 24 PDB header:transferase Chain: A: PDB Molecule:penicillin-binding protein a; PDBTitle: crystal structure of pbpa from mycobacterium tuberculosis 59 d1rp5a4 not modelled 98.0 19 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 60 c1mwuA_ not modelled 97.5 19 PDB header:biosynthetic protein Chain: A: PDB Molecule:penicillin-binding protein 2a; PDBTitle: structure of methicillin acyl-penicillin binding protein 2a2 from methicillin resistant staphylococcus aureus strain3 27r at 2.60 a resolution. 61 c2wadB_ not modelled 97.5 16 PDB header:peptide binding protein Chain: B: PDB Molecule:penicillin-binding protein 2b; PDBTitle: penicillin-binding protein 2b (pbp-2b) from streptococcus2 pneumoniae (strain 5204) 62 c3equB_ not modelled 97.4 15 PDB header:biosynthetic protein Chain: B: PDB Molecule:penicillin-binding protein 2; PDBTitle: crystal structure of penicillin-binding protein 2 from neisseria2 gonorrhoeae 63 c3oc2A_ not modelled 97.0 16 PDB header:penicillin-binding protein Chain: A: PDB Molecule:penicillin-binding protein 3; PDBTitle: crystal structure of penicillin-binding protein 3 from pseudomonas2 aeruginosa 64 d2c5wb1 not modelled 96.8 16 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 65 c3pbqA_ not modelled 96.7 19 PDB header:hydrolase/antibiotic Chain: A: PDB Molecule:penicillin-binding protein 3; PDBTitle: crystal structure of pbp3 complexed with imipenem 66 c1qmfA_ not modelled 96.2 17 PDB header:peptidoglycan synthesis Chain: A: PDB Molecule:penicillin-binding protein 2x; PDBTitle: penicillin-binding protein 2x (pbp-2x) acyl-enzyme complex 67 c3ue3A_ not modelled 96.1 19 PDB header:transferase Chain: A: PDB Molecule:septum formation, penicillin binding protein 3, PDBTitle: crystal structure of acinetobacter baumanni pbp3 68 c3fwlA_ not modelled 95.4 21 PDB header:transferase, hydrolase Chain: A: PDB Molecule:penicillin-binding protein 1b; PDBTitle: crystal structure of the full-length transglycosylase pbp1b2 from escherichia coli 69 c1pmdA_ not modelled 94.9 27 PDB header:peptidoglycan synthesis Chain: A: PDB Molecule:peptidoglycan synthesis multifunctional enzyme; PDBTitle: penicillin-binding protein 2x (pbp-2x) 70 d1k25a4 not modelled 94.8 11 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 71 d1ci9a_ not modelled 94.6 22 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 72 c2qmiH_ not modelled 94.1 17 PDB header:hydrolase Chain: H: PDB Molecule:pbp related beta-lactamase; PDBTitle: structure of the octameric penicillin-binding protein2 homologue from pyrococcus abyssi 73 c3udiA_ not modelled 94.1 20 PDB header:penicillin-binding protein/antibiotic Chain: A: PDB Molecule:penicillin-binding protein 1a; PDBTitle: crystal structure of acinetobacter baumannii pbp1a in complex with2 penicillin g 74 c2olvA_ not modelled 94.0 21 PDB header:transferase Chain: A: PDB Molecule:penicillin-binding protein 2; PDBTitle: structural insight into the transglycosylation step of bacterial cell2 wall biosynthesis : donor ligand complex 75 c3hleA_ 93.8 10 PDB header:transferase Chain: A: PDB Molecule:transesterase; PDBTitle: simvastatin synthase (lovd), from aspergillus terreus, s5 mutant, s76a2 mutant, complex with monacolin j acid 76 c3i7jB_ not modelled 93.6 21 PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase mb2281c; PDBTitle: crystal structure of a beta-lactamase (mb2281c) from2 mycobacterium bovis, northeast structural genomics3 consortium target mbr246 77 c1ei5A_ not modelled 93.4 13 PDB header:hydrolase Chain: A: PDB Molecule:d-aminopeptidase; PDBTitle: crystal structure of a d-aminopeptidase from ochrobactrum2 anthropi 78 c2qz6A_ not modelled 93.1 21 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: first crystal structure of a psychrophile class c beta-2 lactamase 79 c1zkjA_ not modelled 92.9 20 PDB header:hydrolase Chain: A: PDB Molecule:extended-spectrum beta-lactamase; PDBTitle: structural basis for the extended substrate spectrum of cmy-2 10, a plasmid-encoded class c beta-lactamase 80 d2bg1a1 not modelled 92.9 20 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 81 d2drwa1 not modelled 92.6 12 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 82 c2jciA_ not modelled 92.5 17 PDB header:drug-binding protein Chain: A: PDB Molecule:penicillin-binding protein 1b; PDBTitle: structural insights into the catalytic mechanism and the2 role of streptococcus pneumoniae pbp1b 83 c2wzzA_ not modelled 92.4 22 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: amp-c beta-lactamase (pseudomonas aeruginosa)in complex2 with compound m-03 84 d1ei5a3 not modelled 91.9 13 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 85 c3dwkC_ not modelled 91.5 19 PDB header:transferase Chain: C: PDB Molecule:penicillin-binding protein 2; PDBTitle: identification of dynamic structural motifs involved in2 peptidoglycan glycosyltransfer 86 c2bg1A_ not modelled 91.4 20 PDB header:peptidoglycan Chain: A: PDB Molecule:penicillin-binding protein 1b; PDBTitle: active site restructuring regulates ligand recognition in2 classa penicillin-binding proteins (pbps) 87 d1u60a_ not modelled 90.2 22 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:Glutaminase 88 d1rgya_ not modelled 90.1 17 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 89 d1yqsa1 not modelled 88.9 11 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 90 d2hdsa1 not modelled 88.9 20 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 91 c3czdA_ not modelled 88.9 15 PDB header:hydrolase Chain: A: PDB Molecule:glutaminase kidney isoform; PDBTitle: crystal structure of human glutaminase in complex with l-glutamate 92 c3uo9B_ not modelled 88.8 15 PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:glutaminase kidney isoform, mitochondrial; PDBTitle: crystal structure of human gac in complex with glutamate and bptes 93 d2olua2 not modelled 88.6 12 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 94 c2dfwA_ not modelled 88.5 13 PDB header:hydrolase Chain: A: PDB Molecule:salt-tolerant glutaminase; PDBTitle: crystal structure of a major fragment of the salt-tolerant2 glutaminase from micrococcus luteus k-3 95 c2pbyB_ not modelled 88.5 17 PDB header:hydrolase Chain: B: PDB Molecule:glutaminase; PDBTitle: probable glutaminase from geobacillus kaustophilus hta426 96 d1onha_ not modelled 87.8 18 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 97 c3ozhA_ not modelled 87.8 12 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase/d-alanine carboxypeptidase; PDBTitle: crystal structure of beta-lactamase/d-alanine carboxypeptidase from2 yersinia pestis 98 c3ss4C_ not modelled 87.6 15 PDB header:hydrolase Chain: C: PDB Molecule:glutaminase c; PDBTitle: crystal structure of mouse glutaminase c, phosphate-bound form 99 c3ih9A_ not modelled 87.5 15 PDB header:hydrolase Chain: A: PDB Molecule:salt-tolerant glutaminase; PDBTitle: crystal structure analysis of mglu in its tris form 100 c3o3vB_ not modelled 82.5 20 PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of clbp peptidase domain 101 c3tg9A_ not modelled 81.6 13 PDB header:penicillin binding protein Chain: A: PDB Molecule:penicillin-binding protein; PDBTitle: the crystal structure of penicillin binding protein from bacillus2 halodurans 102 d1mkia_ not modelled 79.5 20 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:Glutaminase 103 c3canA_ not modelled 77.0 17 PDB header:lyase activator Chain: A: PDB Molecule:pyruvate-formate lyase-activating enzyme; PDBTitle: crystal structure of a domain of pyruvate-formate lyase-activating2 enzyme from bacteroides vulgatus atcc 8482 104 d2dcfa1 not modelled 76.9 11 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 105 c2yx0A_ not modelled 56.3 17 PDB header:metal binding protein Chain: A: PDB Molecule:radical sam enzyme; PDBTitle: crystal structure of p. horikoshii tyw1 106 d1m53a2 not modelled 56.2 23 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 107 c2z2uA_ not modelled 56.2 17 PDB header:metal binding protein Chain: A: PDB Molecule:upf0026 protein mj0257; PDBTitle: crystal structure of archaeal tyw1 108 d1mxga2 not modelled 51.7 11 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 109 c3cw4A_ not modelled 47.3 27 PDB header:transferase Chain: A: PDB Molecule:polymerase basic protein 2; PDBTitle: large c-terminal domain of influenza a virus rna-dependent polymerase2 pb2 110 d1e43a2 not modelled 43.5 19 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 111 d1n8fa_ not modelled 41.3 26 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I DAHP synthetase 112 c2wskA_ not modelled 40.4 27 PDB header:hydrolase Chain: A: PDB Molecule:glycogen debranching enzyme; PDBTitle: crystal structure of glycogen debranching enzyme glgx from2 escherichia coli k-12 113 d1ob0a2 not modelled 38.2 19 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 114 c3faxA_ not modelled 37.2 15 PDB header:hydrolase Chain: A: PDB Molecule:reticulocyte binding protein; PDBTitle: the crystal structure of gbs pullulanase sap in complex with2 maltotetraose 115 c2a5hC_ not modelled 36.5 20 PDB header:isomerase Chain: C: PDB Molecule:l-lysine 2,3-aminomutase; PDBTitle: 2.1 angstrom x-ray crystal structure of lysine-2,3-aminomutase from2 clostridium subterminale sb4, with michaelis analog (l-alpha-lysine3 external aldimine form of pyridoxal-5'-phosphate). 116 c1ud8A_ not modelled 36.3 21 PDB header:hydrolase Chain: A: PDB Molecule:amylase; PDBTitle: crystal structure of amyk38 with lithium ion 117 c1e40A_ not modelled 35.0 14 PDB header:hydrolase Chain: A: PDB Molecule:alpha-amylase; PDBTitle: tris/maltotriose complex of chimaeric amylase from b.2 amyloliquefaciens and b. licheniformis at 2.2a 118 d2gjpa2 not modelled 34.7 24 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 119 d1hvxa2 not modelled 32.6 13 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 120 d1gcya2 not modelled 32.1 15 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0