Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	F	T	Q	R	L	S	L	R	V	R	L	T	L	I	F	L	I	L	A	S	V	T	W	L	L	S	S	F	V	A	W	K	Q	T	T	D	N	V	D	E	L	F	D	T	Q	L	M	L	F	A	K	R	L	S	T	L	D	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?																																																		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	E	I	N	A	A	D	R	M	A	Q	T	P	N	R	L	K	H	G	H	V	D	D	D	A	L	T	F	A	I	F	T	H	D	G	R	M	V	L	N	D	G	D	N	G	E	D	I	P	Y	S	Y	Q	R	E	G	F	A	D	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																				?					?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Q	L	V	G	E	D	D	P	W	R	F	V	W	M	T	S	P	D	G	K	Y	R	I	V	V	G	Q	E	W	E	Y	R	E	D	M	A	L	A	I	V	A	G	Q	L	I	P	W	L	V	A	L	P	I	M	L	I	I	M	M	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	L	G	R	E	L	A	P	L	N	K	L	A	L	A	L	R	M	R	D	P	D	S	E	K	P	L	N	A	T	G	V	P	S	E	V	R	P	L	V	E	S	L	N	Q	L	F	A	R	T	H	A	M	M	V	R	E	R	R	F
Secondary structure
SS confidence
Disorder																				?	?	?	?	?	?	?	?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	S	D	A	A	H	E	L	R	S	P	L	T	A	L	K	V	Q	T	E	V	A	Q	L	S	D	D	D	P	Q	A	R	K	K	A	L	L	Q	L	H	S	G	I	D	R	A	T	R	L	V	D	Q	L	L	T	L	S	R	L	D
Secondary structure
SS confidence
Disorder																									?			?	?																															?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	L	D	N	L	Q	D	V	A	E	I	P	L	E	D	L	L	Q	S	S	V	M	D	I	Y	H	T	A	Q	Q	A	K	I	D	V	R	L	T	L	N	A	H	S	I	K	R	T	G	Q	P	L	L	L	S	L	L	V	R	N	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	D	N	A	V	R	Y	S	P	Q	G	S	V	V	D	V	T	L	N	A	D	N	F	I	V	R	D	N	G	P	G	V	T	P	E	A	L	A	R	I	G	E	R	F	Y	R	P	P	G	Q	T	A	T	G	S	G	L	G	L	S
Secondary structure
SS confidence
Disorder																																																	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.
Sequence		I	V	Q	R	I	A	K	L	H	G	M	N	V	E	F	G	N	A	E	Q	G	G	F	E	A	K	V	S	W
Secondary structure
SS confidence
Disorder																														?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3d2r chain B Region: 175 - 449 Aligned: 275 Modelled: 275 Confidence: 100.0% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4; PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp Phyre2 PDB 3d36 chain B Region: 230 - 449 Aligned: 212 Modelled: 220 Confidence: 100.0% Identity: 22% PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:sporulation kinase b; PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda Phyre2 PDB 2q8f chain A Region: 178 - 448 Aligned: 267 Modelled: 267 Confidence: 100.0% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1 Phyre2 PDB 2c2a chain A Region: 227 - 449 Aligned: 217 Modelled: 223 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein Phyre2 PDB 2bu8 chain A Region: 174 - 449 Aligned: 273 Modelled: 276 Confidence: 100.0% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2; PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands Phyre2 PDB 1y8o chain A Region: 178 - 449 Aligned: 266 Modelled: 272 Confidence: 100.0% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3; PDBTitle: crystal structure of the pdk3-l2 complex Phyre2 PDB 1gjv chain A Region: 213 - 448 Aligned: 230 Modelled: 236 Confidence: 100.0% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s Phyre2 PDB 3a0r chain A Region: 221 - 449 Aligned: 215 Modelled: 229 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360) Phyre2 PDB 3a0t chain A Region: 306 - 449 Aligned: 141 Modelled: 144 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal) Phyre2 PDB 2c2a chain A domain 2 Region: 305 - 449 Aligned: 139 Modelled: 145 Confidence: 100.0% Identity: 32% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 1id0 chain A Region: 308 - 449 Aligned: 140 Modelled: 142 Confidence: 100.0% Identity: 21% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 1jm6 chain A domain 2 Region: 309 - 449 Aligned: 140 Modelled: 141 Confidence: 99.9% Identity: 19% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain Phyre2 PDB 1gkz chain A domain 2 Region: 309 - 449 Aligned: 139 Modelled: 141 Confidence: 99.9% Identity: 18% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain Phyre2 PDB 3jz3 chain B Region: 276 - 449 Aligned: 148 Modelled: 148 Confidence: 99.9% Identity: 100% PDB header:transferase Chain: B: PDB Molecule:sensor protein qsec; PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec Phyre2 PDB 1bxd chain A Region: 305 - 449 Aligned: 141 Modelled: 145 Confidence: 99.9% Identity: 29% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 1b3q chain A Region: 245 - 449 Aligned: 197 Modelled: 205 Confidence: 99.9% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:protein (chemotaxis protein chea); PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase Phyre2 PDB 1i58 chain A Region: 311 - 449 Aligned: 139 Modelled: 138 Confidence: 99.9% Identity: 15% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 2ch4 chain A Region: 311 - 449 Aligned: 139 Modelled: 139 Confidence: 99.9% Identity: 16% PDB header:transferase/chemotaxis Chain: A: PDB Molecule:chemotaxis protein chea; PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew Phyre2 PDB 1ysr chain A domain 1 Region: 307 - 449 Aligned: 128 Modelled: 143 Confidence: 99.9% Identity: 27% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 1r62 chain A Region: 308 - 449 Aligned: 132 Modelled: 142 Confidence: 99.8% Identity: 17% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 2kse chain A Region: 2 - 33 Aligned: 32 Modelled: 32 Confidence: 84.8% Identity: 100% PDB header:transferase Chain: A: PDB Molecule:sensor protein qsec; PDBTitle: backbone structure of the membrane domain of e. coli2 histidine kinase receptor qsec, center for structures of3 membrane proteins (csmp) target 4311c Phyre2 1 c3d2rB_ 2 c3d36B_ 3 c2q8fA_ 4 c2c2aA_ 5 c2bu8A_ 6 c1y8oA_ 7 c1gjvA_ 8 c3a0rA_ 9 c3a0tA_ 10 d2c2aa2 11 d1id0a_ 12 d1jm6a2 13 d1gkza2 14 c3jz3B_ 15 d1bxda_ 16 c1b3qA_ 17 d1i58a_ 18 c2ch4A_ 19 d1ysra1 20 d1r62a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 c2kseA_ 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3d2rB_ 100.0 14 PDB header:transferase Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4; PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp 2 c3d36B_ 100.0 22 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:sporulation kinase b; PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda 3 c2q8fA_ 100.0 15 PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1 4 c2c2aA_ 100.0 30 PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein 5 c2bu8A_ 100.0 13 PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2; PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands 6 c1y8oA_ 100.0 14 PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3; PDBTitle: crystal structure of the pdk3-l2 complex 7 c1gjvA_ 100.0 15 PDB header:transferase Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s 8 c3a0rA_ 100.0 20 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360) 9 c3a0tA_ 100.0 18 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal) 10 d2c2aa2 100.0 32 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 11 d1id0a_ 100.0 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 12 d1jm6a2 99.9 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain 13 d1gkza2 99.9 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain 14 c3jz3B_ 99.9 100 PDB header:transferase Chain: B: PDB Molecule:sensor protein qsec; PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec 15 d1bxda_ 99.9 29 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 16 c1b3qA_ 99.9 15 PDB header:transferase Chain: A: PDB Molecule:protein (chemotaxis protein chea); PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase 17 d1i58a_ 99.9 15 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 18 c2ch4A_ 99.9 16 PDB header:transferase/chemotaxis Chain: A: PDB Molecule:chemotaxis protein chea; PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew 19 d1ysra1 99.9 27 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 20 d1r62a_ 99.8 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 21 d2hkja3 not modelled 99.8 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 22 c3gieA_ not modelled 99.7 16 PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase desk; PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp 23 c3ehgA_ not modelled 99.7 16 PDB header:transferase Chain: A: PDB Molecule:sensor kinase (yocf protein); PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp 24 c1mx0D_ not modelled 99.6 18 PDB header:isomerase Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b; PDBTitle: structure of topoisomerase subunit 25 c2zbkB_ not modelled 99.6 20 PDB header:isomerase Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b; PDBTitle: crystal structure of an intact type ii dna topoisomerase:2 insights into dna transfer mechanisms 26 c3zxqA_ not modelled 99.6 16 PDB header:transferase Chain: A: PDB Molecule:hypoxia sensor histidine kinase response regulator dost; PDBTitle: crystal structure of the atp-binding domain of mycobacterium2 tuberculosis dost 27 c3zxoB_ not modelled 99.6 21 PDB header:transferase Chain: B: PDB Molecule:redox sensor histidine kinase response regulator devs; PDBTitle: crystal structure of the mutant atp-binding domain of2 mycobacterium tuberculosis doss 28 c2q2eB_ not modelled 99.6 17 PDB header:isomerase Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b; PDBTitle: crystal structure of the topoisomerase vi holoenzyme from2 methanosarcina mazei 29 d1h7sa2 not modelled 99.5 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 30 d1b63a2 not modelled 99.4 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 31 d1th8a_ not modelled 99.4 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 32 d1bkna2 not modelled 99.4 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 33 d1ixma_ not modelled 99.4 12 Fold:Sporulation response regulatory protein Spo0B Superfamily:Sporulation response regulatory protein Spo0B Family:Sporulation response regulatory protein Spo0B 34 d1y8oa2 not modelled 99.3 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain 35 c3na3A_ not modelled 99.1 19 PDB header:protein binding Chain: A: PDB Molecule:dna mismatch repair protein mlh1; PDBTitle: mutl protein homolog 1 isoform 1 from homo sapiens 36 c3h4lB_ not modelled 98.7 19 PDB header:dna binding protein, protein binding Chain: B: PDB Molecule:dna mismatch repair protein pms1; PDBTitle: crystal structure of n terminal domain of a dna repair protein 37 d1kija2 not modelled 98.5 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 38 c3zrwB_ not modelled 98.5 15 PDB header:signaling protein Chain: B: PDB Molecule:af1503 protein, osmolarity sensor protein envz; PDBTitle: the structure of the dimeric hamp-dhp fusion a291v mutant 39 c1bknA_ not modelled 98.5 19 PDB header:dna repair Chain: A: PDB Molecule:mutl; PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl 40 d1ei1a2 not modelled 98.4 24 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 41 d1s16a2 not modelled 98.4 27 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 42 c1ei1B_ not modelled 98.4 24 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase b; PDBTitle: dimerization of e. coli dna gyrase b provides a structural mechanism2 for activating the atpase catalytic center 43 d1pvga2 not modelled 98.3 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 44 c1kijB_ not modelled 98.3 25 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit b; PDBTitle: crystal structure of the 43k atpase domain of thermus thermophilus2 gyrase b in complex with novobiocin 45 c1s16B_ not modelled 98.2 26 PDB header:isomerase Chain: B: PDB Molecule:topoisomerase iv subunit b; PDBTitle: crystal structure of e. coli topoisomerase iv pare 43kda subunit2 complexed with adpnp 46 c1ea6A_ not modelled 98.2 26 PDB header:dna repair Chain: A: PDB Molecule:pms1 protein homolog 2; PDBTitle: n-terminal 40kda fragment of nhpms2 complexed with adp 47 c1zxnB_ not modelled 98.2 22 PDB header:isomerase Chain: B: PDB Molecule:dna topoisomerase ii, alpha isozyme; PDBTitle: human dna topoisomerase iia atpase/adp 48 c3lnrA_ not modelled 98.1 6 PDB header:signaling protein Chain: A: PDB Molecule:aerotaxis transducer aer2; PDBTitle: crystal structure of poly-hamp domains from the p. aeruginosa soluble2 receptor aer2 49 c3iedA_ not modelled 98.1 17 PDB header:chaperone Chain: A: PDB Molecule:heat shock protein; PDBTitle: crystal structure of n-terminal domain of plasmodium falciparum hsp902 (pf14_0417) in complex with amppn 50 c1y4sA_ not modelled 98.1 23 PDB header:chaperone Chain: A: PDB Molecule:chaperone protein htpg; PDBTitle: conformation rearrangement of heat shock protein 90 upon2 adp binding 51 c1qzrA_ not modelled 98.1 19 PDB header:isomerase Chain: A: PDB Molecule:dna topoisomerase ii; PDBTitle: crystal structure of the atpase region of saccharomyces cerevisiae2 topoisomerase ii bound to icrf-187 (dexrazoxane) 52 c3g7bB_ not modelled 98.0 16 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit b; PDBTitle: staphylococcus aureus gyrase b co-complex with inhibitor 53 c2cg9A_ not modelled 98.0 22 PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex 54 d1uyla_ not modelled 97.9 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 55 c2fwyA_ not modelled 97.9 20 PDB header:chaperone Chain: A: PDB Molecule:heat shock protein hsp 90-alpha; PDBTitle: structure of human hsp90-alpha bound to the potent water2 soluble inhibitor pu-h64 56 d1s14a_ not modelled 97.8 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 57 c3lnuA_ not modelled 97.8 28 PDB header:isomerase Chain: A: PDB Molecule:topoisomerase iv subunit b; PDBTitle: crystal structure of pare subunit 58 d2iwxa1 not modelled 97.7 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 59 c1zwhA_ not modelled 97.7 18 PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: yeast hsp82 in complex with the novel hsp90 inhibitor radester amine 60 c2akpA_ not modelled 97.6 18 PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: hsp90 delta24-n210 mutant 61 d1uyma_ not modelled 97.6 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 62 c3pehB_ not modelled 97.6 19 PDB header:chaperone Chain: B: PDB Molecule:endoplasmin homolog; PDBTitle: crystal structure of the n-terminal domain of an hsp90 from plasmodium2 falciparum, pfl1070c in the presence of a thienopyrimidine derivative 63 c2iorA_ not modelled 97.6 23 PDB header:chaperone Chain: A: PDB Molecule:chaperone protein htpg; PDBTitle: crystal structure of the n-terminal domain of htpg, the2 escherichia coli hsp90, bound to adp 64 c3ke6A_ not modelled 97.5 26 PDB header:unknown function Chain: A: PDB Molecule:protein rv1364c/mt1410; PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis 65 c2iopD_ not modelled 97.5 24 PDB header:chaperone Chain: D: PDB Molecule:chaperone protein htpg; PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp 66 d2gqpa1 not modelled 97.4 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 67 c2o1wB_ not modelled 97.4 26 PDB header:chaperone Chain: B: PDB Molecule:endoplasmin; PDBTitle: structure of n-terminal plus middle domains (n+m) of grp94 68 d1qy5a_ not modelled 97.3 27 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 69 d1joya_ not modelled 97.1 18 Fold:ROP-like Superfamily:Homodimeric domain of signal transducing histidine kinase Family:Homodimeric domain of signal transducing histidine kinase 70 d2asxa1 not modelled 97.0 13 Fold:HAMP domain-like Superfamily:HAMP domain-like Family:HAMP domain 71 c2o1uA_ not modelled 97.0 30 PDB header:chaperone Chain: A: PDB Molecule:endoplasmin; PDBTitle: structure of full length grp94 with amp-pnp bound 72 d2c2aa1 not modelled 96.4 28 Fold:ROP-like Superfamily:Homodimeric domain of signal transducing histidine kinase Family:Homodimeric domain of signal transducing histidine kinase 73 c3cwvB_ not modelled 95.4 20 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase, b subunit, truncated; PDBTitle: crystal structure of b-subunit of the dna gyrase from myxococcus2 xanthus 74 c3lmmA_ not modelled 86.2 21 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the dip2311 protein from2 corynebacterium diphtheriae, northeast structural genomics3 consortium target cdr35 75 c2kseA_ 84.8 100 PDB header:transferase Chain: A: PDB Molecule:sensor protein qsec; PDBTitle: backbone structure of the membrane domain of e. coli2 histidine kinase receptor qsec, center for structures of3 membrane proteins (csmp) target 4311c 76 c2rm8A_ not modelled 83.0 10 PDB header:signaling protein Chain: A: PDB Molecule:sensory rhodopsin ii transducer; PDBTitle: the solution structure of phototactic transducer protein2 htrii linker region from natronomonas pharaonis 77 d1g0oa_ not modelled 62.8 23 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 78 c3s8mA_ not modelled 60.4 25 PDB header:oxidoreductase Chain: A: PDB Molecule:enoyl-acp reductase; PDBTitle: the crystal structure of fabv 79 c3ctmH_ not modelled 49.7 19 PDB header:oxidoreductase Chain: H: PDB Molecule:carbonyl reductase; PDBTitle: crystal structure of a carbonyl reductase from candida2 parapsilosis with anti-prelog stereo-specificity 80 c3n0rA_ not modelled 49.6 16 PDB header:signaling protein Chain: A: PDB Molecule:response regulator; PDBTitle: structure of the phyr stress response regulator at 1.25 angstrom2 resolution 81 c3o38D_ not modelled 47.7 29 PDB header:oxidoreductase Chain: D: PDB Molecule:short chain dehydrogenase; PDBTitle: crystal structure of a short chain dehydrogenase from mycobacterium2 smegmatis 82 c3gdfA_ not modelled 40.7 27 PDB header:oxidoreductase Chain: A: PDB Molecule:probable nadp-dependent mannitol dehydrogenase; PDBTitle: crystal structure of the nadp-dependent mannitol dehydrogenase from2 cladosporium herbarum. 83 d1w6ua_ not modelled 31.3 19 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 84 c3r3sD_ not modelled 29.1 23 PDB header:oxidoreductase Chain: D: PDB Molecule:oxidoreductase; PDBTitle: structure of the ygha oxidoreductase from salmonella enterica 85 d3by8a1 not modelled 26.0 10 Fold:Profilin-like Superfamily:Sensory domain-like Family:Sensory domain of two-component sensor kinase 86 c2vz8B_ not modelled 22.0 21 PDB header:transferase Chain: B: PDB Molecule:fatty acid synthase; PDBTitle: crystal structure of mammalian fatty acid synthase 87 d1o57a1 not modelled 18.0 18 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:N-terminal domain of Bacillus PurR 88 d1efub3 not modelled 17.9 11 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:TS-N domain 89 d1xb2b1 not modelled 16.9 11 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:TS-N domain 90 d1veha_ not modelled 16.6 19 Fold:Alpha-lytic protease prodomain-like Superfamily:Fe-S cluster assembly (FSCA) domain-like Family:NifU C-terminal domain-like 91 d1aipc1 not modelled 16.3 26 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:TS-N domain 92 c3ijrF_ not modelled 16.0 25 PDB header:oxidoreductase Chain: F: PDB Molecule:oxidoreductase, short chain dehydrogenase/reductase family; PDBTitle: 2.05 angstrom resolution crystal structure of a short chain2 dehydrogenase from bacillus anthracis str. 'ames ancestor' in complex3 with nad+ 93 d2cp9a1 not modelled 15.8 11 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:TS-N domain 94 c2wpnA_ not modelled 15.8 20 PDB header:oxidoreductase Chain: A: PDB Molecule:periplasmic [nifese] hydrogenase, small subunit; PDBTitle: structure of the oxidised, as-isolated nifese hydrogenase2 from d. vulgaris hildenborough 95 c2zpaB_ not modelled 15.3 23 PDB header:transferase Chain: B: PDB Molecule:uncharacterized protein ypfi; PDBTitle: crystal structure of trna(met) cytidine acetyltransferase 96 d1p0za_ not modelled 15.1 13 Fold:Profilin-like Superfamily:Sensory domain-like Family:Sensory domain of two-component sensor kinase 97 d2cq2a1 not modelled 14.1 32 Fold:Ferredoxin-like Superfamily:RNA-binding domain, RBD Family:Canonical RBD 98 d1odka_ not modelled 13.9 18 Fold:Phosphorylase/hydrolase-like Superfamily:Purine and uridine phosphorylases Family:Purine and uridine phosphorylases 99 c3clwF_ not modelled 13.3 13 PDB header:structural genomics, unknown function Chain: F: PDB Molecule:conserved exported protein; PDBTitle: crystal structure of conserved exported protein from bacteroides2 fragilis

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0