Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	V	K	R	P	V	S	A	S	L	A	R	A	F	F	Y	I	V	L	L	S	I	L	S	T	G	I	A	L	L	T	L	A	S	S	L	R	D	A	E	A	I	N	I	A	G	S	L	R	M	Q	S	Y	R	L	G	Y	D	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																													?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	S	G	S	P	Q	L	N	A	H	R	Q	L	F	Q	Q	A	L	H	S	P	V	L	T	N	L	N	V	W	Y	V	P	E	A	V	K	T	R	Y	A	H	L	N	A	N	W	L	E	M	N	N	R	L	S	K	G	D	L	P	W
Secondary structure
SS confidence
Disorder			?	?	?	?	?												?			?	?	?				?																									?	?	?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Y	Q	A	N	I	N	N	Y	V	N	Q	I	D	L	F	V	L	A	L	Q	H	Y	A	E	R	K	M	L	L	V	V	A	I	S	L	A	G	G	I	G	I	F	T	L	V	F	F	T	L	R	R	I	R	H	Q	V	V	A	P	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		N	Q	L	V	T	A	S	Q	R	I	E	H	G	Q	F	D	S	P	P	L	D	T	N	L	P	N	E	L	G	L	L	A	K	T	F	N	Q	M	S	S	E	L	H	K	L	Y	R	S	L	E	A	S	V	E	E	K	T	R	D	L
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		H	E	A	K	R	R	L	E	V	L	Y	Q	C	S	Q	A	L	N	T	S	Q	I	D	V	H	C	F	R	H	I	L	Q	I	V	R	D	N	E	A	A	E	Y	L	E	L	N	V	G	E	N	W	R	I	S	E	G	Q	P	N	P
Secondary structure
SS confidence
Disorder			?	?		?														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		E	L	P	M	Q	I	L	P	V	T	M	Q	E	T	V	Y	G	E	L	H	W	Q	N	S	H	V	S	S	S	E	P	L	L	N	S	V	S	S	M	L	G	R	G	L	Y	F	N	Q	A	Q	K	H	F	Q	Q	L	L	L	M	E
Secondary structure
SS confidence
Disorder																									?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		E	R	A	T	I	A	R	E	L	H	D	S	L	A	Q	V	L	S	Y	L	R	I	Q	L	T	L	L	K	R	S	I	P	E	D	N	A	T	A	Q	S	I	M	A	D	F	S	Q	A	L	N	D	A	Y	R	Q	L	R	E	L	L
Secondary structure
SS confidence
Disorder																																	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		T	T	F	R	L	T	L	Q	Q	A	D	L	P	S	A	L	R	E	M	L	D	T	L	Q	N	Q	T	S	A	K	L	T	L	D	C	R	L	P	T	L	A	L	D	A	Q	M	Q	V	H	L	L	Q	I	I	R	E	A	V	L	N
Secondary structure
SS confidence
Disorder																																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		A	M	K	H	A	N	A	S	E	I	A	V	S	C	V	T	A	P	D	G	N	H	T	V	Y	I	R	D	N	G	I	G	I	G	E	P	K	E	P	E	G	H	Y	G	L	N	I	M	R	E	R	A	E	R	L	G	G	T	L	T
Secondary structure
SS confidence
Disorder																																				?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.
Sequence		F	S	Q	P	S	G	G	G	T	L	V	S	I	S	F	R	S	A	E	G	E	E	S	Q	L	M
Secondary structure
SS confidence
Disorder																		?			?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2c2a chain A Region: 348 - 559 Aligned: 211 Modelled: 212 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein Phyre2 PDB 3d2r chain B Region: 335 - 564 Aligned: 229 Modelled: 230 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4; PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp Phyre2 PDB 1gjv chain A Region: 323 - 563 Aligned: 240 Modelled: 241 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s Phyre2 PDB 3d36 chain B Region: 356 - 558 Aligned: 200 Modelled: 203 Confidence: 100.0% Identity: 18% PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:sporulation kinase b; PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda Phyre2 PDB 2q8f chain A Region: 342 - 566 Aligned: 224 Modelled: 225 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1 Phyre2 PDB 2bu8 chain A Region: 342 - 564 Aligned: 222 Modelled: 223 Confidence: 100.0% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2; PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands Phyre2 PDB 1y8o chain A Region: 342 - 566 Aligned: 224 Modelled: 225 Confidence: 100.0% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3; PDBTitle: crystal structure of the pdk3-l2 complex Phyre2 PDB 1b3q chain A Region: 370 - 566 Aligned: 191 Modelled: 197 Confidence: 99.9% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:protein (chemotaxis protein chea); PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase Phyre2 PDB 3a0r chain A Region: 235 - 562 Aligned: 320 Modelled: 327 Confidence: 99.9% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360) Phyre2 PDB 2ch4 chain A Region: 432 - 565 Aligned: 133 Modelled: 134 Confidence: 99.9% Identity: 23% PDB header:transferase/chemotaxis Chain: A: PDB Molecule:chemotaxis protein chea; PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew Phyre2 PDB 2c2a chain A domain 2 Region: 424 - 559 Aligned: 135 Modelled: 136 Confidence: 99.9% Identity: 17% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 1gkz chain A domain 2 Region: 432 - 563 Aligned: 131 Modelled: 132 Confidence: 99.9% Identity: 23% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain Phyre2 PDB 1jm6 chain A domain 2 Region: 431 - 566 Aligned: 135 Modelled: 136 Confidence: 99.9% Identity: 20% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain Phyre2 PDB 1ysr chain A domain 1 Region: 426 - 559 Aligned: 132 Modelled: 134 Confidence: 99.9% Identity: 20% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 1id0 chain A Region: 428 - 558 Aligned: 129 Modelled: 131 Confidence: 99.9% Identity: 17% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 1i58 chain A Region: 432 - 558 Aligned: 126 Modelled: 127 Confidence: 99.9% Identity: 23% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 1bxd chain A Region: 424 - 564 Aligned: 137 Modelled: 141 Confidence: 99.9% Identity: 18% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 3gie chain A Region: 335 - 556 Aligned: 202 Modelled: 222 Confidence: 99.9% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase desk; PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp Phyre2 PDB 3a0t chain A Region: 425 - 562 Aligned: 136 Modelled: 138 Confidence: 99.9% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal) Phyre2 PDB 3jz3 chain B Region: 402 - 557 Aligned: 139 Modelled: 156 Confidence: 99.9% Identity: 23% PDB header:transferase Chain: B: PDB Molecule:sensor protein qsec; PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec Phyre2 PDB 3ezi chain B Region: 40 - 139 Aligned: 96 Modelled: 96 Confidence: 97.8% Identity: 28% PDB header:transferase Chain: B: PDB Molecule:nitrate/nitrite sensor protein narx; PDBTitle: crystal structure of the e. coli histidine kinase narx2 sensor domain without ligand Phyre2 PDB 2asx chain A domain 1 Region: 176 - 227 Aligned: 52 Modelled: 52 Confidence: 55.9% Identity: 21% Fold: HAMP domain-like Superfamily: HAMP domain-like Family: HAMP domain Phyre2 1 c2c2aA_ 2 c3d2rB_ 3 c1gjvA_ 4 c3d36B_ 5 c2q8fA_ 6 c2bu8A_ 7 c1y8oA_ 8 c1b3qA_ 9 c3a0rA_ 10 c2ch4A_ 11 d2c2aa2 12 d1gkza2 13 d1jm6a2 14 d1ysra1 15 d1id0a_ 16 d1i58a_ 17 d1bxda_ 18 c3gieA_ 19 c3a0tA_ 20 c3jz3B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 c3eziB_ 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 d2asxa1 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2c2aA_ 100.0 17 PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein 2 c3d2rB_ 100.0 17 PDB header:transferase Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4; PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp 3 c1gjvA_ 100.0 17 PDB header:transferase Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s 4 c3d36B_ 100.0 18 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:sporulation kinase b; PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda 5 c2q8fA_ 100.0 16 PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1 6 c2bu8A_ 100.0 14 PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2; PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands 7 c1y8oA_ 100.0 13 PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3; PDBTitle: crystal structure of the pdk3-l2 complex 8 c1b3qA_ 99.9 18 PDB header:transferase Chain: A: PDB Molecule:protein (chemotaxis protein chea); PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase 9 c3a0rA_ 99.9 12 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360) 10 c2ch4A_ 99.9 23 PDB header:transferase/chemotaxis Chain: A: PDB Molecule:chemotaxis protein chea; PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew 11 d2c2aa2 99.9 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 12 d1gkza2 99.9 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain 13 d1jm6a2 99.9 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain 14 d1ysra1 99.9 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 15 d1id0a_ 99.9 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 16 d1i58a_ 99.9 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 17 d1bxda_ 99.9 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 18 c3gieA_ 99.9 21 PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase desk; PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp 19 c3a0tA_ 99.9 15 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal) 20 c3jz3B_ 99.9 23 PDB header:transferase Chain: B: PDB Molecule:sensor protein qsec; PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec 21 c3ehgA_ not modelled 99.8 22 PDB header:transferase Chain: A: PDB Molecule:sensor kinase (yocf protein); PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp 22 c3zxqA_ not modelled 99.8 30 PDB header:transferase Chain: A: PDB Molecule:hypoxia sensor histidine kinase response regulator dost; PDBTitle: crystal structure of the atp-binding domain of mycobacterium2 tuberculosis dost 23 c3zxoB_ not modelled 99.8 27 PDB header:transferase Chain: B: PDB Molecule:redox sensor histidine kinase response regulator devs; PDBTitle: crystal structure of the mutant atp-binding domain of2 mycobacterium tuberculosis doss 24 d1r62a_ not modelled 99.7 15 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 25 d2hkja3 not modelled 99.6 15 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 26 d1th8a_ not modelled 99.5 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 27 c2zbkB_ not modelled 99.5 16 PDB header:isomerase Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b; PDBTitle: crystal structure of an intact type ii dna topoisomerase:2 insights into dna transfer mechanisms 28 c1mx0D_ not modelled 99.4 16 PDB header:isomerase Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b; PDBTitle: structure of topoisomerase subunit 29 c2q2eB_ not modelled 99.4 23 PDB header:isomerase Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b; PDBTitle: crystal structure of the topoisomerase vi holoenzyme from2 methanosarcina mazei 30 d1ixma_ not modelled 99.3 13 Fold:Sporulation response regulatory protein Spo0B Superfamily:Sporulation response regulatory protein Spo0B Family:Sporulation response regulatory protein Spo0B 31 d1h7sa2 not modelled 99.3 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 32 d1bkna2 not modelled 99.0 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 33 d1y8oa2 not modelled 98.9 13 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain 34 d1b63a2 not modelled 98.9 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 35 c3na3A_ not modelled 98.5 24 PDB header:protein binding Chain: A: PDB Molecule:dna mismatch repair protein mlh1; PDBTitle: mutl protein homolog 1 isoform 1 from homo sapiens 36 c3h4lB_ not modelled 98.5 27 PDB header:dna binding protein, protein binding Chain: B: PDB Molecule:dna mismatch repair protein pms1; PDBTitle: crystal structure of n terminal domain of a dna repair protein 37 c1ea6A_ not modelled 98.4 23 PDB header:dna repair Chain: A: PDB Molecule:pms1 protein homolog 2; PDBTitle: n-terminal 40kda fragment of nhpms2 complexed with adp 38 c1bknA_ not modelled 98.3 27 PDB header:dna repair Chain: A: PDB Molecule:mutl; PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl 39 d1kija2 not modelled 98.2 32 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 40 c3ke6A_ not modelled 98.2 31 PDB header:unknown function Chain: A: PDB Molecule:protein rv1364c/mt1410; PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis 41 c1kijB_ not modelled 98.1 38 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit b; PDBTitle: crystal structure of the 43k atpase domain of thermus thermophilus2 gyrase b in complex with novobiocin 42 d1s16a2 not modelled 98.1 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 43 d1pvga2 not modelled 98.1 24 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 44 c1s16B_ not modelled 98.0 21 PDB header:isomerase Chain: B: PDB Molecule:topoisomerase iv subunit b; PDBTitle: crystal structure of e. coli topoisomerase iv pare 43kda subunit2 complexed with adpnp 45 c1y4sA_ not modelled 98.0 27 PDB header:chaperone Chain: A: PDB Molecule:chaperone protein htpg; PDBTitle: conformation rearrangement of heat shock protein 90 upon2 adp binding 46 c3g7bB_ not modelled 98.0 26 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit b; PDBTitle: staphylococcus aureus gyrase b co-complex with inhibitor 47 d1ei1a2 not modelled 97.9 36 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 48 c1ei1B_ not modelled 97.9 34 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase b; PDBTitle: dimerization of e. coli dna gyrase b provides a structural mechanism2 for activating the atpase catalytic center 49 c2o1uA_ not modelled 97.9 19 PDB header:chaperone Chain: A: PDB Molecule:endoplasmin; PDBTitle: structure of full length grp94 with amp-pnp bound 50 d1s14a_ not modelled 97.9 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 51 c3lnuA_ not modelled 97.8 27 PDB header:isomerase Chain: A: PDB Molecule:topoisomerase iv subunit b; PDBTitle: crystal structure of pare subunit 52 c3pehB_ not modelled 97.8 23 PDB header:chaperone Chain: B: PDB Molecule:endoplasmin homolog; PDBTitle: crystal structure of the n-terminal domain of an hsp90 from plasmodium2 falciparum, pfl1070c in the presence of a thienopyrimidine derivative 53 c2cg9A_ not modelled 97.8 27 PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex 54 d1uyma_ not modelled 97.8 25 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 55 c3eziB_ 97.8 28 PDB header:transferase Chain: B: PDB Molecule:nitrate/nitrite sensor protein narx; PDBTitle: crystal structure of the e. coli histidine kinase narx2 sensor domain without ligand 56 c1zxnB_ not modelled 97.7 30 PDB header:isomerase Chain: B: PDB Molecule:dna topoisomerase ii, alpha isozyme; PDBTitle: human dna topoisomerase iia atpase/adp 57 c2iopD_ not modelled 97.7 25 PDB header:chaperone Chain: D: PDB Molecule:chaperone protein htpg; PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp 58 c1zwhA_ not modelled 97.7 26 PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: yeast hsp82 in complex with the novel hsp90 inhibitor radester amine 59 d2iwxa1 not modelled 97.7 26 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 60 c1qzrA_ not modelled 97.6 28 PDB header:isomerase Chain: A: PDB Molecule:dna topoisomerase ii; PDBTitle: crystal structure of the atpase region of saccharomyces cerevisiae2 topoisomerase ii bound to icrf-187 (dexrazoxane) 61 d2c2aa1 not modelled 97.6 14 Fold:ROP-like Superfamily:Homodimeric domain of signal transducing histidine kinase Family:Homodimeric domain of signal transducing histidine kinase 62 c2fwyA_ not modelled 97.6 18 PDB header:chaperone Chain: A: PDB Molecule:heat shock protein hsp 90-alpha; PDBTitle: structure of human hsp90-alpha bound to the potent water2 soluble inhibitor pu-h64 63 d1uyla_ not modelled 97.5 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 64 c2akpA_ not modelled 97.4 19 PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: hsp90 delta24-n210 mutant 65 c3iedA_ not modelled 97.2 25 PDB header:chaperone Chain: A: PDB Molecule:heat shock protein; PDBTitle: crystal structure of n-terminal domain of plasmodium falciparum hsp902 (pf14_0417) in complex with amppn 66 d1joya_ not modelled 97.1 10 Fold:ROP-like Superfamily:Homodimeric domain of signal transducing histidine kinase Family:Homodimeric domain of signal transducing histidine kinase 67 c2iorA_ not modelled 97.0 30 PDB header:chaperone Chain: A: PDB Molecule:chaperone protein htpg; PDBTitle: crystal structure of the n-terminal domain of htpg, the2 escherichia coli hsp90, bound to adp 68 d1qy5a_ not modelled 97.0 25 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 69 c2o1wB_ not modelled 97.0 25 PDB header:chaperone Chain: B: PDB Molecule:endoplasmin; PDBTitle: structure of n-terminal plus middle domains (n+m) of grp94 70 d2gqpa1 not modelled 96.9 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 71 c3zrwB_ not modelled 95.7 7 PDB header:signaling protein Chain: B: PDB Molecule:af1503 protein, osmolarity sensor protein envz; PDBTitle: the structure of the dimeric hamp-dhp fusion a291v mutant 72 c3cwvB_ not modelled 95.2 11 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase, b subunit, truncated; PDBTitle: crystal structure of b-subunit of the dna gyrase from myxococcus2 xanthus 73 c3lmmA_ not modelled 77.4 18 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the dip2311 protein from2 corynebacterium diphtheriae, northeast structural genomics3 consortium target cdr35 74 d2asxa1 55.9 21 Fold:HAMP domain-like Superfamily:HAMP domain-like Family:HAMP domain 75 c3k7pA_ not modelled 43.3 17 PDB header:isomerase Chain: A: PDB Molecule:ribose 5-phosphate isomerase; PDBTitle: structure of mutant of ribose 5-phosphate isomerase type b from2 trypanosoma cruzi. 76 c3m1pA_ not modelled 43.1 17 PDB header:isomerase Chain: A: PDB Molecule:ribose 5-phosphate isomerase; PDBTitle: structure of ribose 5-phosphate isomerase type b from trypanosoma2 cruzi, soaked with allose-6-phosphate 77 d1j0ga_ not modelled 41.1 22 Fold:beta-Grasp (ubiquitin-like) Superfamily:Ubiquitin-like Family:BM-002-like 78 d1xb2b1 not modelled 28.3 26 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:TS-N domain 79 d1efub3 not modelled 28.2 11 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:TS-N domain 80 d2cp9a1 not modelled 27.9 26 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:TS-N domain 81 d1aipc1 not modelled 22.6 16 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:TS-N domain 82 c2kseA_ not modelled 19.2 11 PDB header:transferase Chain: A: PDB Molecule:sensor protein qsec; PDBTitle: backbone structure of the membrane domain of e. coli2 histidine kinase receptor qsec, center for structures of3 membrane proteins (csmp) target 4311c 83 d1c8ba_ not modelled 18.9 50 Fold:Phosphorylase/hydrolase-like Superfamily:HybD-like Family:Germination protease 84 d1wxsa1 not modelled 18.2 29 Fold:beta-Grasp (ubiquitin-like) Superfamily:Ubiquitin-like Family:BM-002-like 85 d1l7ya_ not modelled 17.2 17 Fold:beta-Grasp (ubiquitin-like) Superfamily:Ubiquitin-like Family:BM-002-like 86 c2crqA_ not modelled 17.0 22 PDB header:translation Chain: A: PDB Molecule:mitochondrial translational initiation factor 3; PDBTitle: solution structure of c-terminal domain of riken cdna2 2810012l14 87 d1g0oa_ not modelled 16.2 17 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 88 c2jnvA_ not modelled 15.9 19 PDB header:metal transport Chain: A: PDB Molecule:nifu-like protein 1, chloroplast; PDBTitle: solution structure of c-terminal domain of nifu-like2 protein from oryza sativa 89 d1nn4a_ not modelled 15.4 22 Fold:Ribose/Galactose isomerase RpiB/AlsB Superfamily:Ribose/Galactose isomerase RpiB/AlsB Family:Ribose/Galactose isomerase RpiB/AlsB 90 c3s8mA_ not modelled 15.2 22 PDB header:oxidoreductase Chain: A: PDB Molecule:enoyl-acp reductase; PDBTitle: the crystal structure of fabv 91 d1fx7a3 not modelled 13.9 28 Fold:SH3-like barrel Superfamily:C-terminal domain of transcriptional repressors Family:FeoA-like 92 d2d7na1 not modelled 13.7 18 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Filamin repeat (rod domain) 93 d1xmta_ not modelled 13.5 11 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:N-acetyl transferase, NAT 94 c3qivA_ not modelled 13.2 18 PDB header:oxidoreductase Chain: A: PDB Molecule:short-chain dehydrogenase or 3-oxoacyl-[acyl-carrier- PDBTitle: crystal structure of a putative short-chain dehydrogenase or 3-2 oxoacyl-[acyl-carrier-protein] reductase from mycobacterium3 paratuberculosis atcc baa-968 / k-10 95 d1s98a_ not modelled 13.0 21 Fold:HesB-like domain Superfamily:HesB-like domain Family:HesB-like domain 96 d1veha_ not modelled 12.8 15 Fold:Alpha-lytic protease prodomain-like Superfamily:Fe-S cluster assembly (FSCA) domain-like Family:NifU C-terminal domain-like 97 d1odka_ not modelled 12.8 12 Fold:Phosphorylase/hydrolase-like Superfamily:Purine and uridine phosphorylases Family:Purine and uridine phosphorylases 98 c3lnrA_ not modelled 12.7 11 PDB header:signaling protein Chain: A: PDB Molecule:aerotaxis transducer aer2; PDBTitle: crystal structure of poly-hamp domains from the p. aeruginosa soluble2 receptor aer2 99 c3k6oA_ not modelled 12.7 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein duf1344; PDBTitle: crystal structure of protein of unknown function duf13442 (yp_001299214.1) from bacteroides vulgatus atcc 8482 at 2.00 a3 resolution

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0