Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	T	L	F	S	R	L	I	T	V	I	A	C	F	F	I	F	S	A	A	W	F	C	L	W	S	I	S	L	H	L	V	E	R	P	D	M	A	V	L	L	F	P	F	G	L	R	L	G	L	M	L	Q	C	P	R	G	Y	W
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	V	L	L	G	A	E	W	L	L	I	Y	W	L	T	Q	A	V	G	L	T	H	F	P	L	L	M	I	G	S	L	L	T	L	L	P	V	A	L	I	S	R	Y	R	H	Q	R	D	W	R	T	L	L	L	Q	G	A	A	L	T
Secondary structure
SS confidence
Disorder																								?																						?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	A	A	L	L	Q	S	L	P	W	L	W	H	G	K	E	S	W	N	A	L	L	L	T	L	T	G	G	L	T	L	A	P	I	C	L	V	F	W	H	Y	L	A	N	N	T	W	L	P	L	G	P	S	L	V	S	Q	P	I	N
Secondary structure
SS confidence
Disorder													?			?	?	?																											?											?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		W	R	G	R	H	L	V	W	Y	L	L	L	F	V	I	S	L	W	L	Q	L	G	L	P	D	E	L	S	R	F	T	P	F	C	L	A	L	P	I	I	A	L	A	W	H	Y	G	W	Q	G	A	L	I	A	T	L	M	N	A	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	L	I	A	S	Q	T	W	R	D	H	P	V	D	L	L	L	S	L	L	V	Q	S	L	T	G	L	L	L	G	A	G	I	Q	R	L	R	E	L	N	Q	S	L	Q	K	E	L	A	R	N	Q	H	L	A	E	R	L	L	E	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		E	E	S	V	R	R	D	V	A	R	E	L	H	D	D	I	G	Q	T	I	T	A	I	R	T	Q	A	G	I	V	Q	R	L	A	A	D	N	A	S	V	K	Q	S	G	Q	L	I	E	Q	L	S	L	G	V	Y	D	A	V	R	R
Secondary structure
SS confidence
Disorder																																	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	L	G	R	L	R	P	R	Q	L	D	D	L	T	L	E	Q	A	I	R	S	L	M	R	E	M	E	L	E	G	R	G	I	V	S	H	L	E	W	R	I	D	E	S	A	L	S	E	N	Q	R	V	T	L	F	R	V	C	Q	E
Secondary structure
SS confidence
Disorder																																													?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		G	L	N	N	I	V	K	H	A	D	A	S	A	V	T	L	Q	G	W	Q	Q	D	E	R	L	M	L	V	I	E	D	D	G	S	G	L	P	P	G	S	G	Q	Q	G	F	G	L	T	G	M	R	E	R	V	T	A	L	G	G	T
Secondary structure
SS confidence
Disorder																																							?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500
Sequence		L	H	I	S	C	L	H	G	T	R	V	S	V	S	L	P	Q	R	Y	V
Secondary structure
SS confidence
Disorder																		?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2c2a chain A Region: 291 - 499 Aligned: 209 Modelled: 209 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein Phyre2 PDB 3d36 chain B Region: 305 - 496 Aligned: 191 Modelled: 192 Confidence: 99.9% Identity: 16% PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:sporulation kinase b; PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda Phyre2 PDB 3d2r chain B Region: 253 - 497 Aligned: 245 Modelled: 245 Confidence: 99.9% Identity: 13% PDB header:transferase Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4; PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp Phyre2 PDB 1gjv chain A Region: 255 - 497 Aligned: 243 Modelled: 243 Confidence: 99.9% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s Phyre2 PDB 2q8f chain A Region: 302 - 500 Aligned: 199 Modelled: 199 Confidence: 99.9% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1 Phyre2 PDB 1y8o chain A Region: 253 - 497 Aligned: 245 Modelled: 245 Confidence: 99.9% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3; PDBTitle: crystal structure of the pdk3-l2 complex Phyre2 PDB 2bu8 chain A Region: 303 - 497 Aligned: 195 Modelled: 195 Confidence: 99.9% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2; PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands Phyre2 PDB 3gie chain A Region: 281 - 496 Aligned: 199 Modelled: 216 Confidence: 99.9% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase desk; PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp Phyre2 PDB 1b3q chain A Region: 313 - 496 Aligned: 184 Modelled: 184 Confidence: 99.8% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:protein (chemotaxis protein chea); PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase Phyre2 PDB 3a0r chain A Region: 298 - 497 Aligned: 200 Modelled: 200 Confidence: 99.8% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360) Phyre2 PDB 1id0 chain A Region: 371 - 499 Aligned: 128 Modelled: 129 Confidence: 99.8% Identity: 23% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 2c2a chain A domain 2 Region: 369 - 499 Aligned: 131 Modelled: 131 Confidence: 99.8% Identity: 21% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 3a0t chain A Region: 369 - 499 Aligned: 131 Modelled: 131 Confidence: 99.8% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal) Phyre2 PDB 1ysr chain A domain 1 Region: 368 - 496 Aligned: 127 Modelled: 129 Confidence: 99.8% Identity: 20% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 3jz3 chain B Region: 344 - 497 Aligned: 140 Modelled: 154 Confidence: 99.7% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:sensor protein qsec; PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec Phyre2 PDB 3ehg chain A Region: 373 - 496 Aligned: 122 Modelled: 124 Confidence: 99.7% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:sensor kinase (yocf protein); PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp Phyre2 PDB 1gkz chain A domain 2 Region: 371 - 497 Aligned: 127 Modelled: 127 Confidence: 99.7% Identity: 23% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain Phyre2 PDB 2ch4 chain A Region: 374 - 496 Aligned: 122 Modelled: 123 Confidence: 99.7% Identity: 20% PDB header:transferase/chemotaxis Chain: A: PDB Molecule:chemotaxis protein chea; PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew Phyre2 PDB 1jm6 chain A domain 2 Region: 374 - 497 Aligned: 124 Modelled: 124 Confidence: 99.7% Identity: 15% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain Phyre2 PDB 1bxd chain A Region: 366 - 498 Aligned: 129 Modelled: 130 Confidence: 99.7% Identity: 19% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 1 c2c2aA_ 2 c3d36B_ 3 c3d2rB_ 4 c1gjvA_ 5 c2q8fA_ 6 c1y8oA_ 7 c2bu8A_ 8 c3gieA_ 9 c1b3qA_ 10 c3a0rA_ 11 d1id0a_ 12 d2c2aa2 13 c3a0tA_ 14 d1ysra1 15 c3jz3B_ 16 c3ehgA_ 17 d1gkza2 18 c2ch4A_ 19 d1jm6a2 20 d1bxda_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2c2aA_ 100.0 19 PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein 2 c3d36B_ 99.9 16 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:sporulation kinase b; PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda 3 c3d2rB_ 99.9 13 PDB header:transferase Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4; PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp 4 c1gjvA_ 99.9 16 PDB header:transferase Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s 5 c2q8fA_ 99.9 14 PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1 6 c1y8oA_ 99.9 15 PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3; PDBTitle: crystal structure of the pdk3-l2 complex 7 c2bu8A_ 99.9 13 PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2; PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands 8 c3gieA_ 99.9 21 PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase desk; PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp 9 c1b3qA_ 99.8 16 PDB header:transferase Chain: A: PDB Molecule:protein (chemotaxis protein chea); PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase 10 c3a0rA_ 99.8 15 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360) 11 d1id0a_ 99.8 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 12 d2c2aa2 99.8 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 13 c3a0tA_ 99.8 15 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal) 14 d1ysra1 99.8 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 15 c3jz3B_ 99.7 19 PDB header:transferase Chain: B: PDB Molecule:sensor protein qsec; PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec 16 c3ehgA_ 99.7 26 PDB header:transferase Chain: A: PDB Molecule:sensor kinase (yocf protein); PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp 17 d1gkza2 99.7 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain 18 c2ch4A_ 99.7 20 PDB header:transferase/chemotaxis Chain: A: PDB Molecule:chemotaxis protein chea; PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew 19 d1jm6a2 99.7 15 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain 20 d1bxda_ 99.7 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 21 d1i58a_ not modelled 99.7 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 22 c3zxqA_ not modelled 99.6 21 PDB header:transferase Chain: A: PDB Molecule:hypoxia sensor histidine kinase response regulator dost; PDBTitle: crystal structure of the atp-binding domain of mycobacterium2 tuberculosis dost 23 c3zxoB_ not modelled 99.5 26 PDB header:transferase Chain: B: PDB Molecule:redox sensor histidine kinase response regulator devs; PDBTitle: crystal structure of the mutant atp-binding domain of2 mycobacterium tuberculosis doss 24 d1r62a_ not modelled 99.5 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 25 d1ixma_ not modelled 99.3 13 Fold:Sporulation response regulatory protein Spo0B Superfamily:Sporulation response regulatory protein Spo0B Family:Sporulation response regulatory protein Spo0B 26 d2hkja3 not modelled 99.2 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 27 d1th8a_ not modelled 99.1 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 28 c2zbkB_ not modelled 99.0 16 PDB header:isomerase Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b; PDBTitle: crystal structure of an intact type ii dna topoisomerase:2 insights into dna transfer mechanisms 29 c1mx0D_ not modelled 98.9 16 PDB header:isomerase Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b; PDBTitle: structure of topoisomerase subunit 30 d1h7sa2 not modelled 98.9 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 31 c2q2eB_ not modelled 98.9 21 PDB header:isomerase Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b; PDBTitle: crystal structure of the topoisomerase vi holoenzyme from2 methanosarcina mazei 32 d1y8oa2 not modelled 98.7 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain 33 d1b63a2 not modelled 98.5 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 34 d1bkna2 not modelled 98.4 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 35 d2c2aa1 not modelled 98.2 16 Fold:ROP-like Superfamily:Homodimeric domain of signal transducing histidine kinase Family:Homodimeric domain of signal transducing histidine kinase 36 c3na3A_ not modelled 98.0 18 PDB header:protein binding Chain: A: PDB Molecule:dna mismatch repair protein mlh1; PDBTitle: mutl protein homolog 1 isoform 1 from homo sapiens 37 c1ea6A_ not modelled 98.0 23 PDB header:dna repair Chain: A: PDB Molecule:pms1 protein homolog 2; PDBTitle: n-terminal 40kda fragment of nhpms2 complexed with adp 38 c3g7bB_ not modelled 97.8 17 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit b; PDBTitle: staphylococcus aureus gyrase b co-complex with inhibitor 39 d1kija2 not modelled 97.8 33 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 40 d1pvga2 not modelled 97.8 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 41 c1kijB_ not modelled 97.8 31 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit b; PDBTitle: crystal structure of the 43k atpase domain of thermus thermophilus2 gyrase b in complex with novobiocin 42 d1ei1a2 not modelled 97.8 33 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 43 c3h4lB_ not modelled 97.7 21 PDB header:dna binding protein, protein binding Chain: B: PDB Molecule:dna mismatch repair protein pms1; PDBTitle: crystal structure of n terminal domain of a dna repair protein 44 c3lnuA_ not modelled 97.7 20 PDB header:isomerase Chain: A: PDB Molecule:topoisomerase iv subunit b; PDBTitle: crystal structure of pare subunit 45 c3ke6A_ not modelled 97.7 21 PDB header:unknown function Chain: A: PDB Molecule:protein rv1364c/mt1410; PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis 46 c1s16B_ not modelled 97.7 28 PDB header:isomerase Chain: B: PDB Molecule:topoisomerase iv subunit b; PDBTitle: crystal structure of e. coli topoisomerase iv pare 43kda subunit2 complexed with adpnp 47 c1ei1B_ not modelled 97.6 33 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase b; PDBTitle: dimerization of e. coli dna gyrase b provides a structural mechanism2 for activating the atpase catalytic center 48 d1joya_ not modelled 97.6 14 Fold:ROP-like Superfamily:Homodimeric domain of signal transducing histidine kinase Family:Homodimeric domain of signal transducing histidine kinase 49 d1s16a2 not modelled 97.6 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 50 c1zxnB_ not modelled 97.5 25 PDB header:isomerase Chain: B: PDB Molecule:dna topoisomerase ii, alpha isozyme; PDBTitle: human dna topoisomerase iia atpase/adp 51 c1bknA_ not modelled 97.5 21 PDB header:dna repair Chain: A: PDB Molecule:mutl; PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl 52 d1s14a_ not modelled 97.5 25 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 53 c1qzrA_ not modelled 97.4 23 PDB header:isomerase Chain: A: PDB Molecule:dna topoisomerase ii; PDBTitle: crystal structure of the atpase region of saccharomyces cerevisiae2 topoisomerase ii bound to icrf-187 (dexrazoxane) 54 c3zrwB_ not modelled 97.4 14 PDB header:signaling protein Chain: B: PDB Molecule:af1503 protein, osmolarity sensor protein envz; PDBTitle: the structure of the dimeric hamp-dhp fusion a291v mutant 55 c1y4sA_ not modelled 97.3 22 PDB header:chaperone Chain: A: PDB Molecule:chaperone protein htpg; PDBTitle: conformation rearrangement of heat shock protein 90 upon2 adp binding 56 c3iedA_ not modelled 96.7 20 PDB header:chaperone Chain: A: PDB Molecule:heat shock protein; PDBTitle: crystal structure of n-terminal domain of plasmodium falciparum hsp902 (pf14_0417) in complex with amppn 57 c2fwyA_ not modelled 96.7 16 PDB header:chaperone Chain: A: PDB Molecule:heat shock protein hsp 90-alpha; PDBTitle: structure of human hsp90-alpha bound to the potent water2 soluble inhibitor pu-h64 58 d1uyla_ not modelled 96.7 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 59 d1uyma_ not modelled 96.5 14 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 60 c2akpA_ not modelled 96.5 19 PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: hsp90 delta24-n210 mutant 61 d1qy5a_ not modelled 96.4 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 62 c2iorA_ not modelled 96.4 16 PDB header:chaperone Chain: A: PDB Molecule:chaperone protein htpg; PDBTitle: crystal structure of the n-terminal domain of htpg, the2 escherichia coli hsp90, bound to adp 63 c3pehB_ not modelled 96.3 18 PDB header:chaperone Chain: B: PDB Molecule:endoplasmin homolog; PDBTitle: crystal structure of the n-terminal domain of an hsp90 from plasmodium2 falciparum, pfl1070c in the presence of a thienopyrimidine derivative 64 c1zwhA_ not modelled 96.3 18 PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: yeast hsp82 in complex with the novel hsp90 inhibitor radester amine 65 d2iwxa1 not modelled 96.2 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 66 c2o1wB_ not modelled 96.1 22 PDB header:chaperone Chain: B: PDB Molecule:endoplasmin; PDBTitle: structure of n-terminal plus middle domains (n+m) of grp94 67 c2o1uA_ not modelled 96.0 20 PDB header:chaperone Chain: A: PDB Molecule:endoplasmin; PDBTitle: structure of full length grp94 with amp-pnp bound 68 c2cg9A_ not modelled 95.9 18 PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex 69 c2iopD_ not modelled 95.9 20 PDB header:chaperone Chain: D: PDB Molecule:chaperone protein htpg; PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp 70 d2gqpa1 not modelled 95.8 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 71 c3cwvB_ not modelled 95.6 14 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase, b subunit, truncated; PDBTitle: crystal structure of b-subunit of the dna gyrase from myxococcus2 xanthus 72 c3lmmA_ not modelled 94.3 21 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the dip2311 protein from2 corynebacterium diphtheriae, northeast structural genomics3 consortium target cdr35 73 d1j0ga_ not modelled 28.4 29 Fold:beta-Grasp (ubiquitin-like) Superfamily:Ubiquitin-like Family:BM-002-like 74 d2asba3 not modelled 28.0 21 Fold:Alpha-lytic protease prodomain-like Superfamily:Prokaryotic type KH domain (KH-domain type II) Family:Prokaryotic type KH domain (KH-domain type II) 75 d1xb2b1 not modelled 25.9 21 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:TS-N domain 76 d1efub3 not modelled 25.9 21 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:TS-N domain 77 c3m1pA_ not modelled 25.4 18 PDB header:isomerase Chain: A: PDB Molecule:ribose 5-phosphate isomerase; PDBTitle: structure of ribose 5-phosphate isomerase type b from trypanosoma2 cruzi, soaked with allose-6-phosphate 78 c3k7pA_ not modelled 25.4 18 PDB header:isomerase Chain: A: PDB Molecule:ribose 5-phosphate isomerase; PDBTitle: structure of mutant of ribose 5-phosphate isomerase type b from2 trypanosoma cruzi. 79 d2cp9a1 not modelled 24.6 21 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:TS-N domain 80 c2xh3B_ not modelled 23.9 12 PDB header:hydrolase Chain: B: PDB Molecule:spd1 nuclease; PDBTitle: extracellular nuclease 81 d1p0ha_ not modelled 23.3 19 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:N-acetyl transferase, NAT 82 d1aipc1 not modelled 22.5 16 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:TS-N domain 83 c3a0oB_ not modelled 22.0 28 PDB header:lyase Chain: B: PDB Molecule:oligo alginate lyase; PDBTitle: crystal structure of alginate lyase from agrobacterium tumefaciens c58 84 c3d4cA_ not modelled 20.7 21 PDB header:cell adhesion Chain: A: PDB Molecule:maltose-binding periplasmic protein, linker, zona pellucida PDBTitle: zp-n domain of mammalian sperm receptor zp3 (crystal form i) 85 c2jnvA_ not modelled 20.7 31 PDB header:metal transport Chain: A: PDB Molecule:nifu-like protein 1, chloroplast; PDBTitle: solution structure of c-terminal domain of nifu-like2 protein from oryza sativa 86 c2wpwA_ not modelled 20.4 4 PDB header:transferase Chain: A: PDB Molecule:orf14; PDBTitle: tandem gnat protein from the clavulanic acid biosynthesis2 pathway (without accoa) 87 c1w8xN_ not modelled 18.3 15 PDB header:virus Chain: N: PDB Molecule:protein p31; PDBTitle: structural analysis of prd1 88 c3c26A_ not modelled 18.1 20 PDB header:transferase Chain: A: PDB Molecule:putative acetyltransferase ta0821; PDBTitle: crystal structure of a putative acetyltransferase (np_394282.1) from2 thermoplasma acidophilum at 2.00 a resolution 89 d1l7ya_ not modelled 18.1 25 Fold:beta-Grasp (ubiquitin-like) Superfamily:Ubiquitin-like Family:BM-002-like 90 c3myfB_ not modelled 17.2 11 PDB header:transferase Chain: B: PDB Molecule:sensor protein; PDBTitle: the crystal structure of the hpt domain from the hpt sensor hybrid2 histidine kinase from shewanella to 1.80a 91 d1xmta_ not modelled 17.0 7 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:N-acetyl transferase, NAT 92 d1veha_ not modelled 17.0 23 Fold:Alpha-lytic protease prodomain-like Superfamily:Fe-S cluster assembly (FSCA) domain-like Family:NifU C-terminal domain-like 93 d1r57a_ not modelled 17.0 13 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:N-acetyl transferase, NAT 94 c1qysA_ not modelled 16.8 23 PDB header:de novo protein Chain: A: PDB Molecule:top7; PDBTitle: crystal structure of top7: a computationally designed2 protein with a novel fold 95 d1qfha2 not modelled 16.7 17 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Filamin repeat (rod domain) 96 c3rghA_ not modelled 16.6 22 PDB header:cell adhesion Chain: A: PDB Molecule:filamin-a; PDBTitle: structure of filamin a immunoglobulin-like repeat 10 from homo sapiens 97 c1yz7A_ not modelled 16.6 7 PDB header:translation Chain: A: PDB Molecule:probable translation initiation factor 2 alpha PDBTitle: crystal structure of a c-terminal segment of the alpha2 subunit of aif2 from pyrococcus abyssi 98 d2d7na1 not modelled 16.6 15 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Filamin repeat (rod domain) 99 d1hh2p3 not modelled 16.4 18 Fold:Alpha-lytic protease prodomain-like Superfamily:Prokaryotic type KH domain (KH-domain type II) Family:Prokaryotic type KH domain (KH-domain type II)

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0