Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	D	M	A	E	R	L	A	L	H	E	F	T	E	N	A	Y	L	N	Y	S	M	Y	V	I	M	D	R	A	L	P	F	I	G	D	G	L	K	P	V	Q	R	R	I	V	Y	A	M	S	E	L	G	L	N	A	S	A	K	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																													?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	K	S	A	R	T	V	G	D	V	L	G	K	Y	H	P	H	G	D	S	A	C	Y	E	A	M	V	L	M	A	Q	P	F	S	Y	R	Y	P	L	V	D	G	Q	G	N	W	G	A	P	D	D	P	K	S	F	A	A	M	R	Y
Secondary structure
SS confidence
Disorder																																																	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	E	S	R	L	S	K	Y	S	E	L	L	L	S	E	L	G	Q	G	T	A	D	W	V	P	N	F	D	G	T	L	Q	E	P	K	M	L	P	A	R	L	P	N	I	L	L	N	G	T	T	G	I	A	V	G	M	A	T	D	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	P	H	N	L	R	E	V	A	Q	A	A	I	A	L	I	D	Q	P	K	T	T	L	D	Q	L	L	D	I	V	Q	G	P	D	Y	P	T	E	A	E	I	I	T	S	R	A	E	I	R	K	I	Y	E	N	G	R	G	S	V	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		M	R	A	V	W	K	K	E	D	G	A	V	V	I	S	A	L	P	H	Q	V	S	G	A	R	V	L	E	Q	I	A	A	Q	M	R	N	K	K	L	P	M	V	D	D	L	R	D	E	S	D	H	E	N	P	T	R	L	V	I	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		P	R	S	N	R	V	D	M	D	Q	V	M	N	H	L	F	A	T	T	D	L	E	K	S	Y	R	I	N	L	N	M	I	G	L	D	G	R	P	A	V	K	N	L	L	E	I	L	S	E	W	L	V	F	R	R	D	T	V	R	R
Secondary structure
SS confidence
Disorder			?	?	?	?	?															?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	L	N	Y	R	L	E	K	V	L	K	R	L	H	I	L	E	G	L	L	V	A	F	L	N	I	D	E	V	I	E	I	I	R	N	E	D	E	P	K	P	A	L	M	S	R	F	G	L	T	E	T	Q	A	E	A	I	L	E	L
Secondary structure
SS confidence
Disorder																																			?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		K	L	R	H	L	A	K	L	E	E	M	K	I	R	G	E	Q	S	E	L	E	K	E	R	D	Q	L	Q	G	I	L	A	S	E	R	K	M	N	N	L	L	K	K	E	L	Q	A	D	A	Q	A	Y	G	D	D	R	R	S	P	L
Secondary structure
SS confidence
Disorder																																																									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		Q	E	R	E	E	A	K	A	M	S	E	H	D	M	L	P	S	E	P	V	T	I	V	L	S	Q	M	G	W	V	R	S	A	K	G	H	D	I	D	A	P	G	L	N	Y	K	A	G	D	S	F	K	A	A	V	K	G	K	S	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?		?		?	?	?																			?				?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		Q	P	V	V	F	V	D	S	T	G	R	S	Y	A	I	D	P	I	T	L	P	S	A	R	G	Q	G	E	P	L	T	G	K	L	T	L	P	P	G	A	T	V	D	H	M	L	M	E	S	D	D	Q	K	L	L	M	A	S	D	A
Secondary structure
SS confidence
Disorder																							?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		G	Y	G	F	V	C	T	F	N	D	L	V	A	R	N	R	A	G	K	A	L	I	T	L	P	E	N	A	H	V	M	P	P	V	V	I	E	D	A	S	D	M	L	L	A	I	T	Q	A	G	R	M	L	M	F	P	V	S	D	L
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence		P	Q	L	S	K	G	K	G	N	K	I	I	N	I	P	S	A	E	A	A	R	G	E	D	G	L	A	Q	L	Y	V	L	P	P	Q	S	T	L	T	I	H	V	G	K	R	K	I	K	L	R	P	E	E	L	Q	K	V	T	G	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?		?	?										?																										?	?									?			?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.
Sequence		R	G	R	R	G	T	L	M	R	G	L	Q	R	I	D	R	V	E	I	D	S	P	R	R	A	S	S	G	D	S	E	E
Secondary structure
SS confidence
Disorder		?	?	?		?	?																			?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1zvu chain A Region: 28 - 739 Aligned: 684 Modelled: 697 Confidence: 100.0% Identity: 99% PDB header:isomerase Chain: A: PDB Molecule:topoisomerase iv subunit a; PDBTitle: structure of the full-length e. coli parc subunit Phyre2 PDB 2xcs chain D Region: 3 - 480 Aligned: 474 Modelled: 478 Confidence: 100.0% Identity: 45% PDB header:isomerase Chain: D: PDB Molecule:dna gyrase subunit b, dna gyrase subunit a; PDBTitle: the 2.1a crystal structure of s. aureus gyrase complex with gsk2994232 and dna Phyre2 PDB 2xkj chain E Region: 1 - 489 Aligned: 489 Modelled: 489 Confidence: 100.0% Identity: 67% PDB header:isomerase Chain: E: PDB Molecule:topoisomerase iv; PDBTitle: crystal structure of catalytic core of a. baumannii topo iv2 (pare-parc fusion truncate) Phyre2 PDB 2wl2 chain B Region: 10 - 480 Aligned: 466 Modelled: 471 Confidence: 100.0% Identity: 46% PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit a; PDBTitle: crystal structure of n-terminal domain of gyra with the2 antibiotic simocyclinone d8 Phyre2 PDB 3ifz chain A Region: 3 - 481 Aligned: 475 Modelled: 479 Confidence: 100.0% Identity: 41% PDB header:isomerase Chain: A: PDB Molecule:dna gyrase subunit a; PDBTitle: crystal structure of the first part of the mycobacterium tuberculosis2 dna gyrase reaction core: the breakage and reunion domain at 2.7 a3 resolution Phyre2 PDB 1ab4 chain A Region: 27 - 480 Aligned: 443 Modelled: 447 Confidence: 100.0% Identity: 47% Fold: Type II DNA topoisomerase Superfamily: Type II DNA topoisomerase Family: Type II DNA topoisomerase Phyre2 PDB 2xcq chain A Region: 23 - 481 Aligned: 452 Modelled: 459 Confidence: 100.0% Identity: 47% PDB header:isomerase Chain: A: PDB Molecule:dna gyrase subunit b, dna gyrase subunit a; PDBTitle: the 2.98a crystal structure of the catalytic core (b'a'2 region) of staphylococcus aureus dna gyrase Phyre2 PDB 3ilw chain A Region: 27 - 482 Aligned: 452 Modelled: 456 Confidence: 100.0% Identity: 41% PDB header:isomerase Chain: A: PDB Molecule:dna gyrase subunit a; PDBTitle: structure of dna gyrase subunit a n-terminal domain Phyre2 PDB 2inr chain A Region: 30 - 486 Aligned: 438 Modelled: 457 Confidence: 100.0% Identity: 42% PDB header:isomerase Chain: A: PDB Molecule:dna topoisomerase 4 subunit a; PDBTitle: crystal structure of a 59 kda fragment of topoisomerase iv subunit a2 (grla) from staphylococcus aureus Phyre2 PDB 2nov chain D Region: 30 - 480 Aligned: 435 Modelled: 451 Confidence: 100.0% Identity: 42% PDB header:isomerase Chain: D: PDB Molecule:dna topoisomerase 4 subunit a; PDBTitle: breakage-reunion domain of s.pneumoniae topo iv: crystal2 structure of a gram-positive quinolone target Phyre2 PDB 3qx3 chain B Region: 3 - 475 Aligned: 446 Modelled: 466 Confidence: 100.0% Identity: 22% PDB header:isomerase/dna/isomerase inhibitor Chain: B: PDB Molecule:dna topoisomerase 2-beta; PDBTitle: human topoisomerase iibeta in complex with dna and etoposide Phyre2 PDB 1bjt chain A Region: 9 - 472 Aligned: 434 Modelled: 459 Confidence: 100.0% Identity: 23% PDB header:topoisomerase Chain: A: PDB Molecule:topoisomerase ii; PDBTitle: topoisomerase ii residues 409-1201 Phyre2 PDB 1bjt chain A Region: 9 - 472 Aligned: 434 Modelled: 459 Confidence: 100.0% Identity: 23% Fold: Type II DNA topoisomerase Superfamily: Type II DNA topoisomerase Family: Type II DNA topoisomerase Phyre2 PDB 3l6v chain A Region: 493 - 751 Aligned: 249 Modelled: 259 Confidence: 100.0% Identity: 20% PDB header:isomerase Chain: A: PDB Molecule:dna gyrase subunit a; PDBTitle: crystal structure of the xanthomonas campestris gyrase a c-2 terminal domain Phyre2 PDB 1wp5 chain A Region: 495 - 752 Aligned: 249 Modelled: 258 Confidence: 100.0% Identity: 15% Fold: 6-bladed beta-propeller Superfamily: GyrA/ParC C-terminal domain-like Family: GyrA/ParC C-terminal domain-like Phyre2 PDB 1zvt chain A Region: 497 - 742 Aligned: 245 Modelled: 246 Confidence: 100.0% Identity: 100% PDB header:isomerase Chain: A: PDB Molecule:topoisomerase iv subunit a; PDBTitle: structure of the e. coli parc c-terminal domain Phyre2 PDB 1zi0 chain A Region: 497 - 751 Aligned: 233 Modelled: 255 Confidence: 100.0% Identity: 18% PDB header:isomerase, dna bindng protein Chain: A: PDB Molecule:dna gyrase subunit a; PDBTitle: a superhelical spiral in escherichia coli dna gyrase a c-2 terminal domain imparts unidirectional supercoiling bias Phyre2 PDB 1suu chain A Region: 498 - 751 Aligned: 236 Modelled: 254 Confidence: 100.0% Identity: 16% Fold: 6-bladed beta-propeller Superfamily: GyrA/ParC C-terminal domain-like Family: GyrA/ParC C-terminal domain-like Phyre2 PDB 3no0 chain B Region: 500 - 751 Aligned: 221 Modelled: 252 Confidence: 100.0% Identity: 18% PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit a; PDBTitle: aquifex aeolicus type iia topoisomerase c-terminal domain Phyre2 PDB 1x75 chain A domain 1 Region: 359 - 453 Aligned: 95 Modelled: 95 Confidence: 99.9% Identity: 48% Fold: Type II DNA topoisomerase Superfamily: Type II DNA topoisomerase Family: Type II DNA topoisomerase Phyre2 1 c1zvuA_ 2 c2xcsD_ 3 c2xkjE_ 4 c2wl2B_ 5 c3ifzA_ 6 d1ab4a_ 7 c2xcqA_ 8 c3ilwA_ 9 c2inrA_ 10 c2novD_ 11 c3qx3B_ 12 c1bjtA_ 13 d1bjta_ 14 c3l6vA_ 15 d1wp5a_ 16 c1zvtA_ 17 c1zi0A_ 18 d1suua_ 19 c3no0B_ 20 d1x75a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99