Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	E	N	A	K	M	N	S	L	I	A	Q	Y	P	L	V	K	D	L	V	A	L	K	E	T	T	W	F	N	P	G	T	T	S	L	A	E	G	L	P	Y	V	G	L	T	E	Q	D	V	Q	D	A	H	A	R	L	S	R	F	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?		?		?						?	?	?	?															?	?	?		?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	Y	L	A	K	A	F	P	E	T	A	A	T	G	G	I	I	E	S	E	L	V	A	I	P	A	M	Q	K	R	L	E	K	E	Y	Q	Q	P	I	S	G	Q	L	L	L	K	K	D	S	H	L	P	I	S	G	S	I	K	A	R
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?														?	?		?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	G	I	Y	E	V	L	A	H	A	E	K	L	A	L	E	A	G	L	L	T	L	D	D	D	Y	S	K	L	L	S	P	E	F	K	Q	F	F	S	Q	Y	S	I	A	V	G	S	T	G	N	L	G	L	S	I	G	I	M	S	A
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	I	G	F	K	V	T	V	H	M	S	A	D	A	R	A	W	K	K	A	K	L	R	S	H	G	V	T	V	V	E	Y	E	Q	D	Y	G	V	A	V	E	E	G	R	K	A	A	Q	S	D	P	N	C	F	F	I	D	D	E	N
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	R	T	L	F	L	G	Y	S	V	A	G	Q	R	L	K	A	Q	F	A	Q	Q	G	R	I	V	D	A	D	N	P	L	F	V	Y	L	P	C	G	V	G	G	G	P	G	G	V	A	F	G	L	K	L	A	F	G	D	H	V	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		C	F	F	A	E	P	T	H	S	P	C	M	L	L	G	V	H	T	G	L	H	D	Q	I	S	V	Q	D	I	G	I	D	N	L	T	A	A	D	G	L	A	V	G	R	A	S	G	F	V	G	R	A	M	E	R	L	L	D	G	F
Secondary structure
SS confidence
Disorder																												?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		Y	T	L	S	D	Q	T	M	Y	D	M	L	G	W	L	A	Q	E	E	G	I	R	L	E	P	S	A	L	A	G	M	A	G	P	Q	R	V	C	A	S	V	S	Y	Q	Q	M	H	G	F	S	A	E	Q	L	R	N	T	T	H	L
Secondary structure
SS confidence
Disorder																																										?	?	?	?		?	?	?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.
Sequence		V	W	A	T	G	G	G	M	V	P	E	E	E	M	N	Q	Y	L	A	K	G	R
Secondary structure
SS confidence
Disorder																					?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3r0z chain A Region: 1 - 442 Aligned: 433 Modelled: 442 Confidence: 100.0% Identity: 89% PDB header:lyase Chain: A: PDB Molecule:d-serine dehydratase; PDBTitle: crystal structure of apo d-serine deaminase from salmonella2 typhimurium Phyre2 PDB 1tdj chain A Region: 65 - 441 Aligned: 314 Modelled: 344 Confidence: 100.0% Identity: 21% PDB header:allostery Chain: A: PDB Molecule:biosynthetic threonine deaminase; PDBTitle: threonine deaminase (biosynthetic) from e. coli Phyre2 PDB 1pwh chain A Region: 76 - 440 Aligned: 312 Modelled: 331 Confidence: 100.0% Identity: 21% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 3l6c chain A Region: 40 - 431 Aligned: 318 Modelled: 353 Confidence: 100.0% Identity: 16% PDB header:isomerase Chain: A: PDB Molecule:serine racemase; PDBTitle: x-ray crystal structure of rat serine racemase in complex with2 malonate a potent inhibitor Phyre2 PDB 3iau chain A Region: 71 - 441 Aligned: 307 Modelled: 337 Confidence: 100.0% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:threonine deaminase; PDBTitle: the structure of the processed form of threonine deaminase isoform 22 from solanum lycopersicum Phyre2 PDB 2gn0 chain A Region: 41 - 439 Aligned: 319 Modelled: 350 Confidence: 100.0% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:threonine dehydratase catabolic; PDBTitle: crystal structure of dimeric biodegradative threonine deaminase (tdcb)2 from salmonella typhimurium at 1.7 a resolution (triclinic form with3 one complete subunit built in alternate conformation) Phyre2 PDB 1p5j chain A Region: 76 - 440 Aligned: 312 Modelled: 339 Confidence: 100.0% Identity: 19% PDB header:lyase Chain: A: PDB Molecule:l-serine dehydratase; PDBTitle: crystal structure analysis of human serine dehydratase Phyre2 PDB 1p5j chain A Region: 76 - 440 Aligned: 312 Modelled: 339 Confidence: 100.0% Identity: 19% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1v71 chain A domain 1 Region: 44 - 440 Aligned: 316 Modelled: 342 Confidence: 100.0% Identity: 21% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 2rkb chain E Region: 76 - 440 Aligned: 311 Modelled: 331 Confidence: 100.0% Identity: 20% PDB header:lyase Chain: E: PDB Molecule:serine dehydratase-like; PDBTitle: serine dehydratase like-1 from human cancer cells Phyre2 PDB 1ve5 chain A domain 1 Region: 45 - 429 Aligned: 304 Modelled: 327 Confidence: 100.0% Identity: 25% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 2zsj chain B Region: 56 - 440 Aligned: 322 Modelled: 345 Confidence: 100.0% Identity: 19% PDB header:lyase Chain: B: PDB Molecule:threonine synthase; PDBTitle: crystal structure of threonine synthase from aquifex aeolicus vf5 Phyre2 PDB 3pc3 chain A Region: 58 - 440 Aligned: 311 Modelled: 347 Confidence: 100.0% Identity: 20% PDB header:lyase Chain: A: PDB Molecule:cg1753, isoform a; PDBTitle: full length structure of cystathionine beta-synthase from drosophila2 in complex with aminoacrylate Phyre2 PDB 1jbq chain A Region: 71 - 440 Aligned: 305 Modelled: 342 Confidence: 100.0% Identity: 18% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 2d1f chain A Region: 56 - 438 Aligned: 317 Modelled: 349 Confidence: 100.0% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:threonine synthase; PDBTitle: structure of mycobacterium tuberculosis threonine synthase Phyre2 PDB 1jbq chain D Region: 71 - 440 Aligned: 305 Modelled: 342 Confidence: 100.0% Identity: 18% PDB header:lyase Chain: D: PDB Molecule:cystathionine beta-synthase; PDBTitle: structure of human cystathionine beta-synthase: a unique pyridoxal 5'-2 phosphate dependent hemeprotein Phyre2 PDB 1tdj chain A domain 1 Region: 65 - 440 Aligned: 313 Modelled: 343 Confidence: 100.0% Identity: 21% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1v7c chain A Region: 56 - 438 Aligned: 318 Modelled: 351 Confidence: 100.0% Identity: 22% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1e5x chain A Region: 56 - 442 Aligned: 319 Modelled: 341 Confidence: 100.0% Identity: 16% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1z7w chain A domain 1 Region: 76 - 442 Aligned: 299 Modelled: 323 Confidence: 100.0% Identity: 19% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 1 c3r0zA_ 2 c1tdjA_ 3 d1pwha_ 4 c3l6cA_ 5 c3iauA_ 6 c2gn0A_ 7 c1p5jA_ 8 d1p5ja_ 9 d1v71a1 10 c2rkbE_ 11 d1ve5a1 12 c2zsjB_ 13 c3pc3A_ 14 d1jbqa_ 15 c2d1fA_ 16 c1jbqD_ 17 d1tdja1 18 d1v7ca_ 19 d1e5xa_ 20 d1z7wa1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3r0zA_ 100.0 89 PDB header:lyase Chain: A: PDB Molecule:d-serine dehydratase; PDBTitle: crystal structure of apo d-serine deaminase from salmonella2 typhimurium 2 c1tdjA_ 100.0 21 PDB header:allostery Chain: A: PDB Molecule:biosynthetic threonine deaminase; PDBTitle: threonine deaminase (biosynthetic) from e. coli 3 d1pwha_ 100.0 21 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 4 c3l6cA_ 100.0 16 PDB header:isomerase Chain: A: PDB Molecule:serine racemase; PDBTitle: x-ray crystal structure of rat serine racemase in complex with2 malonate a potent inhibitor 5 c3iauA_ 100.0 21 PDB header:lyase Chain: A: PDB Molecule:threonine deaminase; PDBTitle: the structure of the processed form of threonine deaminase isoform 22 from solanum lycopersicum 6 c2gn0A_ 100.0 21 PDB header:lyase Chain: A: PDB Molecule:threonine dehydratase catabolic; PDBTitle: crystal structure of dimeric biodegradative threonine deaminase (tdcb)2 from salmonella typhimurium at 1.7 a resolution (triclinic form with3 one complete subunit built in alternate conformation) 7 c1p5jA_ 100.0 19 PDB header:lyase Chain: A: PDB Molecule:l-serine dehydratase; PDBTitle: crystal structure analysis of human serine dehydratase 8 d1p5ja_ 100.0 19 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 9 d1v71a1 100.0 21 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 10 c2rkbE_ 100.0 20 PDB header:lyase Chain: E: PDB Molecule:serine dehydratase-like; PDBTitle: serine dehydratase like-1 from human cancer cells 11 d1ve5a1 100.0 25 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 12 c2zsjB_ 100.0 19 PDB header:lyase Chain: B: PDB Molecule:threonine synthase; PDBTitle: crystal structure of threonine synthase from aquifex aeolicus vf5 13 c3pc3A_ 100.0 20 PDB header:lyase Chain: A: PDB Molecule:cg1753, isoform a; PDBTitle: full length structure of cystathionine beta-synthase from drosophila2 in complex with aminoacrylate 14 d1jbqa_ 100.0 18 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 15 c2d1fA_ 100.0 21 PDB header:lyase Chain: A: PDB Molecule:threonine synthase; PDBTitle: structure of mycobacterium tuberculosis threonine synthase 16 c1jbqD_ 100.0 18 PDB header:lyase Chain: D: PDB Molecule:cystathionine beta-synthase; PDBTitle: structure of human cystathionine beta-synthase: a unique pyridoxal 5'-2 phosphate dependent hemeprotein 17 d1tdja1 100.0 21 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 18 d1v7ca_ 100.0 22 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 19 d1e5xa_ 100.0 16 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 20 d1z7wa1 100.0 19 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 21 c1x1qA_ not modelled 100.0 15 PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase beta chain; PDBTitle: crystal structure of tryptophan synthase beta chain from thermus2 thermophilus hb8 22 c2pqmA_ not modelled 100.0 18 PDB header:lyase Chain: A: PDB Molecule:cysteine synthase; PDBTitle: crystal structure of cysteine synthase (oass) from entamoeba2 histolytica at 1.86 a resolution 23 d1qopb_ not modelled 100.0 16 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 24 c3dwgA_ not modelled 100.0 19 PDB header:transferase Chain: A: PDB Molecule:cysteine synthase b; PDBTitle: crystal structure of a sulfur carrier protein complex found in the2 cysteine biosynthetic pathway of mycobacterium tuberculosis 25 d1ve1a1 not modelled 100.0 23 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 26 d1v8za1 not modelled 100.0 16 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 27 d1y7la1 not modelled 100.0 21 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 28 d1wkva1 not modelled 100.0 15 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 29 d1fcja_ not modelled 100.0 22 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 30 d2bhsa1 not modelled 100.0 20 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 31 c2q3bA_ not modelled 100.0 21 PDB header:transferase Chain: A: PDB Molecule:cysteine synthase a; PDBTitle: 1.8 a resolution crystal structure of o-acetylserine sulfhydrylase2 (oass) holoenzyme from mycobacterium tuberculosis 32 d1o58a_ not modelled 100.0 23 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 33 c2o2jA_ not modelled 100.0 21 PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase beta chain; PDBTitle: mycobacterium tuberculosis tryptophan synthase beta chain2 dimer (apoform) 34 c2eguA_ not modelled 100.0 22 PDB header:transferase Chain: A: PDB Molecule:cysteine synthase; PDBTitle: crystal structure of o-acetylserine sulfhydrase from geobacillus2 kaustophilus hta426 35 d1f2da_ not modelled 100.0 15 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 36 d1tyza_ not modelled 100.0 17 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 37 d1j0aa_ not modelled 100.0 17 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 38 d1vb3a1 not modelled 100.0 18 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 39 c3v7nA_ not modelled 100.0 11 PDB header:lyase Chain: A: PDB Molecule:threonine synthase; PDBTitle: crystal structure of threonine synthase (thrc) from from burkholderia2 thailandensis 40 d1kl7a_ not modelled 100.0 13 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 41 d1vp8a_ not modelled 95.2 20 Fold:Pyruvate kinase C-terminal domain-like Superfamily:PK C-terminal domain-like Family:MTH1675-like 42 d1c1da1 not modelled 94.2 28 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain 43 d1l7da1 not modelled 88.2 23 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 44 d1ml4a2 not modelled 87.5 13 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 45 d1xgka_ not modelled 87.5 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 46 d1cdoa2 not modelled 86.6 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 47 d1o8ca2 not modelled 86.1 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 48 d1t57a_ not modelled 86.0 17 Fold:Pyruvate kinase C-terminal domain-like Superfamily:PK C-terminal domain-like Family:MTH1675-like 49 c3iupB_ not modelled 84.9 12 PDB header:oxidoreductase Chain: B: PDB Molecule:putative nadph:quinone oxidoreductase; PDBTitle: crystal structure of putative nadph:quinone oxidoreductase2 (yp_296108.1) from ralstonia eutropha jmp134 at 1.70 a resolution 50 c1ml4A_ not modelled 82.7 15 PDB header:transferase Chain: A: PDB Molecule:aspartate transcarbamoylase; PDBTitle: the pala-liganded aspartate transcarbamoylase catalytic subunit from2 pyrococcus abyssi 51 d1p0fa2 not modelled 82.3 14 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 52 c3krtC_ not modelled 80.3 18 PDB header:oxidoreductase Chain: C: PDB Molecule:crotonyl coa reductase; PDBTitle: crystal structure of putative crotonyl coa reductase from streptomyces2 coelicolor a3(2) 53 c2rgwD_ not modelled 79.8 10 PDB header:transferase Chain: D: PDB Molecule:aspartate carbamoyltransferase; PDBTitle: catalytic subunit of m. jannaschii aspartate2 transcarbamoylase 54 c3ndnC_ not modelled 76.4 13 PDB header:lyase Chain: C: PDB Molecule:o-succinylhomoserine sulfhydrylase; PDBTitle: crystal structure of o-succinylhomoserine sulfhydrylase from2 mycobacterium tuberculosis covalently bound to pyridoxal-5-phosphate 55 d1o89a2 not modelled 76.3 24 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 56 c3d64A_ not modelled 74.0 15 PDB header:hydrolase Chain: A: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of s-adenosyl-l-homocysteine hydrolase from2 burkholderia pseudomallei 57 c3dhyC_ not modelled 73.3 12 PDB header:hydrolase Chain: C: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structures of mycobacterium tuberculosis s-adenosyl-l-2 homocysteine hydrolase in ternary complex with substrate and3 inhibitors 58 c3oneA_ not modelled 71.3 13 PDB header:hydrolase/hydrolase substrate Chain: A: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of lupinus luteus s-adenosyl-l-homocysteine2 hydrolase in complex with adenine 59 c3n58D_ not modelled 70.7 15 PDB header:hydrolase Chain: D: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of s-adenosyl-l-homocysteine hydrolase from brucella2 melitensis in ternary complex with nad and adenosine, orthorhombic3 form 60 d1ekxa2 not modelled 70.6 11 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 61 d1bg6a2 not modelled 65.8 18 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:6-phosphogluconate dehydrogenase-like, N-terminal domain 62 c2vhyB_ not modelled 65.7 19 PDB header:oxidoreductase Chain: B: PDB Molecule:alanine dehydrogenase; PDBTitle: crystal structure of apo l-alanine dehydrogenase from2 mycobacterium tuberculosis 63 c1d4fD_ not modelled 65.3 14 PDB header:hydrolase Chain: D: PDB Molecule:s-adenosylhomocysteine hydrolase; PDBTitle: crystal structure of recombinant rat-liver d244e mutant s-2 adenosylhomocysteine hydrolase 64 d1tt7a2 not modelled 65.2 19 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 65 d1mdoa_ not modelled 63.9 15 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:GABA-aminotransferase-like 66 d1otha2 not modelled 63.0 17 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 67 d1fg7a_ not modelled 62.1 13 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:AAT-like 68 c3jtxB_ not modelled 58.5 13 PDB header:transferase Chain: B: PDB Molecule:aminotransferase; PDBTitle: crystal structure of aminotransferase (np_283882.1) from neisseria2 meningitidis z2491 at 1.91 a resolution 69 d1pvva2 not modelled 57.5 24 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 70 c3ketA_ not modelled 57.2 16 PDB header:transcription/dna Chain: A: PDB Molecule:redox-sensing transcriptional repressor rex; PDBTitle: crystal structure of a rex-family transcriptional regulatory protein2 from streptococcus agalactiae bound to a palindromic operator 71 d1u3wa2 not modelled 57.0 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 72 c1l7eC_ not modelled 56.8 18 PDB header:oxidoreductase Chain: C: PDB Molecule:nicotinamide nucleotide transhydrogenase, PDBTitle: crystal structure of r. rubrum transhydrogenase domain i2 with bound nadh 73 c2qx7A_ not modelled 56.1 22 PDB header:plant protein Chain: A: PDB Molecule:eugenol synthase 1; PDBTitle: structure of eugenol synthase from ocimum basilicum 74 d1pg5a2 not modelled 56.0 18 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 75 d1d1ta2 not modelled 55.6 14 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 76 d1o69a_ not modelled 55.2 9 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:GABA-aminotransferase-like 77 c2c7tA_ not modelled 55.1 12 PDB header:transferase Chain: A: PDB Molecule:glutamine-2-deoxy-scyllo-inosose PDBTitle: crystal structure of the plp-bound form of btrr,2 a dual functional aminotransferase involved in butirosin3 biosynthesis. 78 c3p2yA_ not modelled 54.8 24 PDB header:oxidoreductase Chain: A: PDB Molecule:alanine dehydrogenase/pyridine nucleotide transhydrogenase; PDBTitle: crystal structure of alanine dehydrogenase/pyridine nucleotide2 transhydrogenase from mycobacterium smegmatis 79 d2bwna1 not modelled 53.8 8 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:GABA-aminotransferase-like 80 c3c1oA_ not modelled 53.7 21 PDB header:oxidoreductase Chain: A: PDB Molecule:eugenol synthase; PDBTitle: the multiple phenylpropene synthases in both clarkia2 breweri and petunia hybrida represent two distinct lineages 81 c3eywA_ not modelled 53.6 20 PDB header:transport protein Chain: A: PDB Molecule:c-terminal domain of glutathione-regulated potassium-efflux PDBTitle: crystal structure of the c-terminal domain of e. coli kefc in complex2 with keff 82 c3d4oA_ not modelled 52.7 23 PDB header:oxidoreductase Chain: A: PDB Molecule:dipicolinate synthase subunit a; PDBTitle: crystal structure of dipicolinate synthase subunit a (np_243269.1)2 from bacillus halodurans at 2.10 a resolution 83 c2bruB_ not modelled 52.4 21 PDB header:oxidoreductase Chain: B: PDB Molecule:nad(p) transhydrogenase subunit alpha; PDBTitle: complex of the domain i and domain iii of escherichia coli2 transhydrogenase 84 d1vpda2 not modelled 51.7 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:6-phosphogluconate dehydrogenase-like, N-terminal domain 85 d1trba1 not modelled 51.5 13 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 86 d1u7za_ not modelled 50.8 18 Fold:Ribokinase-like Superfamily:CoaB-like Family:CoaB-like 87 d1e3ia2 not modelled 50.5 16 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 88 c2gk4A_ not modelled 50.0 29 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein; PDBTitle: the crystal structure of the dna/pantothenate metabolism flavoprotein2 from streptococcus pneumoniae 89 c1v8bA_ not modelled 49.7 15 PDB header:hydrolase Chain: A: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of a hydrolase 90 c3q98A_ not modelled 49.7 16 PDB header:transferase Chain: A: PDB Molecule:transcarbamylase; PDBTitle: structure of ygew encoded protein from e. coli 91 d1wvga1 not modelled 49.1 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 92 d1b9ha_ not modelled 48.9 10 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:GABA-aminotransferase-like 93 c2gf2B_ not modelled 48.9 15 PDB header:oxidoreductase Chain: B: PDB Molecule:3-hydroxyisobutyrate dehydrogenase; PDBTitle: crystal structure of human hydroxyisobutyrate dehydrogenase 94 c3k7yA_ not modelled 48.7 4 PDB header:transferase Chain: A: PDB Molecule:aspartate aminotransferase; PDBTitle: aspartate aminotransferase of plasmodium falciparum 95 d1pjca1 not modelled 47.7 16 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 96 c1vpdA_ not modelled 47.1 21 PDB header:oxidoreductase Chain: A: PDB Molecule:tartronate semialdehyde reductase; PDBTitle: x-ray crystal structure of tartronate semialdehyde reductase2 [salmonella typhimurium lt2] 97 c3ffrA_ not modelled 47.1 10 PDB header:transferase Chain: A: PDB Molecule:phosphoserine aminotransferase serc; PDBTitle: crystal structure of a phosphoserine aminotransferase serc (chu_0995)2 from cytophaga hutchinsonii atcc 33406 at 1.75 a resolution 98 c3pduF_ not modelled 47.1 26 PDB header:oxidoreductase Chain: F: PDB Molecule:3-hydroxyisobutyrate dehydrogenase family protein; PDBTitle: crystal structure of gamma-hydroxybutyrate dehydrogenase from2 geobacter sulfurreducens in complex with nadp+ 99 d2jhfa2 not modelled 46.9 20 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 100 c3cumA_ not modelled 46.3 20 PDB header:oxidoreductase Chain: A: PDB Molecule:probable 3-hydroxyisobutyrate dehydrogenase; PDBTitle: crystal structure of a possible 3-hydroxyisobutyrate dehydrogenase2 from pseudomonas aeruginosa pao1 101 d1tuga1 not modelled 46.3 13 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 102 c4a10A_ not modelled 46.3 29 PDB header:oxidoreductase Chain: A: PDB Molecule:octenoyl-coa reductase/carboxylase; PDBTitle: apo-structure of 2-octenoyl-coa carboxylase reductase cinf from2 streptomyces sp. 103 c1gthD_ not modelled 46.3 18 PDB header:oxidoreductase Chain: D: PDB Molecule:dihydropyrimidine dehydrogenase; PDBTitle: dihydropyrimidine dehydrogenase (dpd) from pig, ternary2 complex with nadph and 5-iodouracil 104 d2ay1a_ not modelled 45.9 12 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:AAT-like 105 c2dt5A_ not modelled 45.5 25 PDB header:dna binding protein Chain: A: PDB Molecule:at-rich dna-binding protein; PDBTitle: crystal structure of ttha1657 (at-rich dna-binding protein) from2 thermus thermophilus hb8 106 d1hyua1 not modelled 45.0 22 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 107 c2o0rA_ not modelled 44.8 18 PDB header:transferase Chain: A: PDB Molecule:rv0858c (n-succinyldiaminopimelate aminotransferase); PDBTitle: the three-dimensional structure of n-succinyldiaminopimelate2 aminotransferase from mycobacterium tuberculosis 108 d1llua2 not modelled 43.9 17 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 109 c3bcxA_ not modelled 43.6 13 PDB header:transferase Chain: A: PDB Molecule:cdp-6-deoxy-l-threo-d-glycero-4-hexulose-3- PDBTitle: e1 dehydrase 110 c3gvpB_ not modelled 43.2 13 PDB header:hydrolase Chain: B: PDB Molecule:adenosylhomocysteinase 3; PDBTitle: human sahh-like domain of human adenosylhomocysteinase 3 111 d1kola2 not modelled 43.1 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 112 d1xa0a2 not modelled 42.7 24 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 113 c3qhaB_ not modelled 42.6 26 PDB header:oxidoreductase Chain: B: PDB Molecule:putative oxidoreductase; PDBTitle: crystal structure of a putative oxidoreductase from mycobacterium2 avium 104 114 c3fwzA_ not modelled 42.2 18 PDB header:membrane protein Chain: A: PDB Molecule:inner membrane protein ybal; PDBTitle: crystal structure of trka-n domain of inner membrane protein ybal from2 escherichia coli 115 c2po3B_ not modelled 41.5 18 PDB header:transferase Chain: B: PDB Molecule:4-dehydrase; PDBTitle: crystal structure analysis of desi in the presence of its2 tdp-sugar product 116 c3pefA_ not modelled 41.3 17 PDB header:oxidoreductase Chain: A: PDB Molecule:6-phosphogluconate dehydrogenase, nad-binding; PDBTitle: crystal structure of gamma-hydroxybutyrate dehydrogenase from2 geobacter metallireducens in complex with nadp+ 117 d1vdca1 not modelled 41.2 19 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 118 c3s8mA_ not modelled 41.0 14 PDB header:oxidoreductase Chain: A: PDB Molecule:enoyl-acp reductase; PDBTitle: the crystal structure of fabv 119 c1ortD_ not modelled 40.7 22 PDB header:transferase Chain: D: PDB Molecule:ornithine transcarbamoylase; PDBTitle: ornithine transcarbamoylase from pseudomonas aeruginosa 120 d2hmva1 not modelled 39.3 22 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Potassium channel NAD-binding domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0