Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	R	T	T	P	I	A	R	Y	R	N	I	G	I	S	A	H	I	D	A	G	K	T	T	T	T	E	R	I	L	F	Y	T	G	V	N	H	K	I	G	E	V	H	D	G	A	A	T	M	D	W	M	E	Q	E	Q	E	R	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?																												?		?	?	?	?	?	?	?	?				?										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	T	I	T	S	A	A	T	T	A	F	W	S	G	M	A	K	Q	Y	E	P	H	R	I	N	I	I	D	T	P	G	H	V	D	F	T	I	E	V	E	R	S	M	R	V	L	D	G	A	V	M	V	Y	C	A	V	G	G	V	Q
Secondary structure
SS confidence
Disorder																?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	Q	S	E	T	V	W	R	Q	A	N	K	Y	K	V	P	R	I	A	F	V	N	K	M	D	R	M	G	A	N	F	L	K	V	V	N	Q	I	K	T	R	L	G	A	N	P	V	P	L	Q	L	A	I	G	A	E	E	H	F	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	V	V	D	L	V	K	M	K	A	I	N	W	N	D	A	D	Q	G	V	T	F	E	Y	E	D	I	P	A	D	M	V	E	L	A	N	E	W	H	Q	N	L	I	E	S	A	A	E	A	S	E	E	L	M	E	K	Y	L	G	G
Secondary structure
SS confidence
Disorder													?				?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	E	L	T	E	A	E	I	K	G	A	L	R	Q	R	V	L	N	N	E	I	I	L	V	T	C	G	S	A	F	K	N	K	G	V	Q	A	M	L	D	A	V	I	D	Y	L	P	S	P	V	D	V	P	A	I	N	G	I	L	D
Secondary structure
SS confidence
Disorder																													?	?	?	?																						?		?	?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		D	G	K	D	T	P	A	E	R	H	A	S	D	D	E	P	F	S	A	L	A	F	K	I	A	T	D	P	F	V	G	N	L	T	F	F	R	V	Y	S	G	V	V	N	S	G	D	T	V	L	N	S	V	K	A	A	R	E	R	F
Secondary structure
SS confidence
Disorder		?		?																								?																									?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	R	I	V	Q	M	H	A	N	K	R	E	E	I	K	E	V	R	A	G	D	I	A	A	A	I	G	L	K	D	V	T	T	G	D	T	L	C	D	P	D	A	P	I	I	L	E	R	M	E	F	P	E	P	V	I	S	I	A	V
Secondary structure
SS confidence
Disorder										?	?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		E	P	K	T	K	A	D	Q	E	K	M	G	L	A	L	G	R	L	A	K	E	D	P	S	F	R	V	W	T	D	E	E	S	N	Q	T	I	I	A	G	M	G	E	L	H	L	D	I	I	V	D	R	M	K	R	E	F	N	V	E
Secondary structure
SS confidence
Disorder				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		A	N	V	G	K	P	Q	V	A	Y	R	E	T	I	R	Q	K	V	T	D	V	E	G	K	H	A	K	Q	S	G	G	R	G	Q	Y	G	H	V	V	I	D	M	Y	P	L	E	P	G	S	N	P	K	G	Y	E	F	I	N	D	I
Secondary structure
SS confidence
Disorder																				?	?	?	?					?		?	?	?	?	?																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		K	G	G	V	I	P	G	E	Y	I	P	A	V	D	K	G	I	Q	E	Q	L	K	A	G	P	L	A	G	Y	P	V	V	D	M	G	I	R	L	H	F	G	S	Y	H	D	V	D	S	S	E	L	A	F	K	L	A	A	S	I	A
Secondary structure
SS confidence
Disorder																																														?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		F	K	E	G	F	K	K	A	K	P	V	L	L	E	P	I	M	K	V	E	V	E	T	P	E	E	N	T	G	D	V	I	G	D	L	S	R	R	R	G	M	L	K	G	Q	E	S	E	V	T	G	V	K	I	H	A	E	V	P	L
Secondary structure
SS confidence
Disorder																																							?		?						?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.
Sequence		S	E	M	F	G	Y	A	T	Q	L	R	S	L	T	K	G	R	A	S	Y	T	M	E	F	L	K	Y	D	E	A	P	S	N	V	A	Q	A	V	I	E	A	R	G	K
Secondary structure
SS confidence
Disorder						?																																						?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2rdo chain 7 Region: 1 - 704 Aligned: 684 Modelled: 684 Confidence: 100.0% Identity: 98% PDB header:ribosome Chain: 7: PDB Molecule:elongation factor g; PDBTitle: 50s subunit with ef-g(gdpnp) and rrf bound Phyre2 PDB 2xex chain A Region: 2 - 703 Aligned: 662 Modelled: 677 Confidence: 100.0% Identity: 59% PDB header:translation Chain: A: PDB Molecule:elongation factor g; PDBTitle: crystal structure of staphylococcus aureus elongation factor2 g Phyre2 PDB 2bm0 chain A Region: 2 - 700 Aligned: 665 Modelled: 675 Confidence: 100.0% Identity: 59% PDB header:elongation factor Chain: A: PDB Molecule:elongation factor g; PDBTitle: ribosomal elongation factor g (ef-g) fusidic acid resistant2 mutant t84a Phyre2 PDB 1zn0 chain B Region: 5 - 699 Aligned: 653 Modelled: 667 Confidence: 100.0% Identity: 60% PDB header:translation/biosynthetic protein/rna Chain: B: PDB Molecule:elongation factor g; PDBTitle: coordinates of rrf and ef-g fitted into cryo-em map of the2 50s subunit bound with both ef-g (gdpnp) and rrf Phyre2 PDB 2dy1 chain A Region: 8 - 704 Aligned: 655 Modelled: 670 Confidence: 100.0% Identity: 35% PDB header:signaling protein, translation Chain: A: PDB Molecule:elongation factor g; PDBTitle: crystal structure of ef-g-2 from thermus thermophilus Phyre2 PDB 3b8h chain A Region: 3 - 702 Aligned: 683 Modelled: 700 Confidence: 100.0% Identity: 25% PDB header:biosynthetic protein/transferase Chain: A: PDB Molecule:elongation factor 2; PDBTitle: structure of the eef2-exoa(e546a)-nad+ complex Phyre2 PDB 3deg chain C Region: 7 - 691 Aligned: 470 Modelled: 470 Confidence: 100.0% Identity: 29% PDB header:ribosome Chain: C: PDB Molecule:gtp-binding protein lepa; PDBTitle: complex of elongating escherichia coli 70s ribosome and ef4(lepa)-2 gmppnp Phyre2 PDB 3tr5 chain C Region: 4 - 517 Aligned: 471 Modelled: 479 Confidence: 100.0% Identity: 25% PDB header:translation Chain: C: PDB Molecule:peptide chain release factor 3; PDBTitle: structure of a peptide chain release factor 3 (prfc) from coxiella2 burnetii Phyre2 PDB 2ywf chain A Region: 8 - 691 Aligned: 451 Modelled: 463 Confidence: 100.0% Identity: 33% PDB header:translation Chain: A: PDB Molecule:gtp-binding protein lepa; PDBTitle: crystal structure of gmppnp-bound lepa from aquifex aeolicus Phyre2 PDB 3cb4 chain D Region: 7 - 691 Aligned: 440 Modelled: 462 Confidence: 100.0% Identity: 28% PDB header:translation Chain: D: PDB Molecule:gtp-binding protein lepa; PDBTitle: the crystal structure of lepa Phyre2 PDB 2h5e chain B Region: 7 - 526 Aligned: 448 Modelled: 485 Confidence: 100.0% Identity: 25% PDB header:translation Chain: B: PDB Molecule:peptide chain release factor rf-3; PDBTitle: crystal structure of e.coli polypeptide release factor rf3 Phyre2 PDB 1wb1 chain C Region: 2 - 619 Aligned: 462 Modelled: 499 Confidence: 100.0% Identity: 19% PDB header:protein synthesis Chain: C: PDB Molecule:translation elongation factor selb; PDBTitle: crystal structure of translation elongation factor selb2 from methanococcus maripaludis in complex with gdp Phyre2 PDB 3izq chain 1 Region: 1 - 411 Aligned: 296 Modelled: 303 Confidence: 100.0% Identity: 24% PDB header:ribosomal protein,hydrolase Chain: 1: PDB Molecule:elongation factor 1 alpha-like protein; PDBTitle: structure of the dom34-hbs1-gdpnp complex bound to a translating2 ribosome Phyre2 PDB 1zun chain B Region: 1 - 405 Aligned: 287 Modelled: 310 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: B: PDB Molecule:sulfate adenylate transferase, subunit PDBTitle: crystal structure of a gtp-regulated atp sulfurylase2 heterodimer from pseudomonas syringae Phyre2 PDB 1g7c chain A Region: 12 - 411 Aligned: 302 Modelled: 318 Confidence: 100.0% Identity: 23% PDB header:translation Chain: A: PDB Molecule:elongation factor 1-alpha; PDBTitle: yeast eef1a:eef1ba in complex with gdpnp Phyre2 PDB 1mj1 chain A Region: 12 - 405 Aligned: 277 Modelled: 285 Confidence: 100.0% Identity: 28% PDB header:ribosome Chain: A: PDB Molecule:elongation factor tu; PDBTitle: fitting the ternary complex of ef-tu/trna/gtp and ribosomal proteins2 into a 13 a cryo-em map of the coli 70s ribosome Phyre2 PDB 1g7t chain A Region: 9 - 397 Aligned: 305 Modelled: 318 Confidence: 100.0% Identity: 19% PDB header:translation Chain: A: PDB Molecule:translation initiation factor if2/eif5b; PDBTitle: x-ray structure of translation initiation factor if2/eif5b2 complexed with gdpnp Phyre2 PDB 3p27 chain A Region: 12 - 411 Aligned: 274 Modelled: 300 Confidence: 100.0% Identity: 20% PDB header:signaling protein Chain: A: PDB Molecule:elongation factor 1 alpha-like protein; PDBTitle: crystal structure of a translational gtpase (gdp form) Phyre2 PDB 1d2e chain A Region: 12 - 405 Aligned: 275 Modelled: 290 Confidence: 100.0% Identity: 28% PDB header:rna binding protein Chain: A: PDB Molecule:elongation factor tu (ef-tu); PDBTitle: crystal structure of mitochondrial ef-tu in complex with gdp Phyre2 PDB 1n0u chain A domain 2 Region: 6 - 287 Aligned: 269 Modelled: 270 Confidence: 100.0% Identity: 23% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: G proteins Phyre2 1 c2rdo7_ 2 c2xexA_ 3 c2bm0A_ 4 c1zn0B_ 5 c2dy1A_ 6 c3b8hA_ 7 c3degC_ 8 c3tr5C_ 9 c2ywfA_ 10 c3cb4D_ 11 c2h5eB_ 12 c1wb1C_ 13 c3izq1_ 14 c1zunB_ 15 c1g7cA_ 16 c1mj1A_ 17 c1g7tA_ 18 c3p27A_ 19 c1d2eA_ 20 d1n0ua2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499