Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	K	I	F	N	T	L	T	R	Q	K	E	E	F	K	P	I	H	A	G	E	V	G	M	Y	V	C	G	I	T	V	Y	D	L	C	H	I	G	H	G	R	T	F	V	A	F	D	V	V	A	R	Y	L	R	F	L	G	Y	K
Secondary structure
SS confidence
Disorder		?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	K	Y	V	R	N	I	T	D	I	D	D	K	I	I	K	R	A	N	E	N	G	E	S	F	V	A	M	V	D	R	M	I	A	E	M	H	K	D	F	D	A	L	N	I	L	R	P	D	M	E	P	R	A	T	H	H	I	A	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	I	E	L	T	E	Q	L	I	A	K	G	H	A	Y	V	A	D	N	G	D	V	M	F	D	V	P	T	D	P	T	Y	G	V	L	S	R	Q	D	L	D	Q	L	Q	A	G	A	R	V	D	V	V	D	D	K	R	N	P	M	D
Secondary structure
SS confidence
Disorder																																																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	V	L	W	K	M	S	K	E	G	E	P	S	W	P	S	P	W	G	A	G	R	P	G	W	H	I	E	C	S	A	M	N	C	K	Q	L	G	N	H	F	D	I	H	G	G	G	S	D	L	M	F	P	H	H	E	N	E	I	A
Secondary structure
SS confidence
Disorder										?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Q	S	T	C	A	H	D	G	Q	Y	V	N	Y	W	M	H	S	G	M	V	M	V	D	R	E	K	M	S	K	S	L	G	N	F	F	T	V	R	D	V	L	K	Y	Y	D	A	E	T	V	R	Y	F	L	M	S	G	H	Y	R	S
Secondary structure
SS confidence
Disorder																							?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Q	L	N	Y	S	E	E	N	L	K	Q	A	R	A	A	L	E	R	L	Y	T	A	L	R	G	T	D	K	T	V	A	P	A	G	G	E	A	F	E	A	R	F	I	E	A	M	D	D	D	F	N	T	P	E	A	Y	S	V	L	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		D	M	A	R	E	V	N	R	L	K	A	E	D	M	A	A	A	N	A	M	A	S	H	L	R	K	L	S	A	V	L	G	L	L	E	Q	E	P	E	A	F	L	Q	S	G	A	Q	A	D	D	S	E	V	A	E	I	E	A	L	I
Secondary structure
SS confidence
Disorder																																							?	?		?		?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.
Sequence		Q	Q	R	L	D	A	R	K	A	K	D	W	A	A	A	D	A	A	R	D	R	L	N	E	M	G	I	V	L	E	D	G	P	Q	G	T	T	W	R	R	K
Secondary structure
SS confidence
Disorder																																				?	?					?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1u0b chain B Region: 1 - 461 Aligned: 461 Modelled: 461 Confidence: 100.0% Identity: 100% PDB header:ligase/rna Chain: B: PDB Molecule:cysteinyl trna; PDBTitle: crystal structure of cysteinyl-trna synthetase binary2 complex with trnacys Phyre2 PDB 3sp1 chain B Region: 1 - 460 Aligned: 418 Modelled: 437 Confidence: 100.0% Identity: 33% PDB header:ligase Chain: B: PDB Molecule:cysteinyl-trna synthetase; PDBTitle: crystal structure of cysteinyl-trna synthetase (cyss) from borrelia2 burgdorferi Phyre2 PDB 3c8z chain B Region: 2 - 390 Aligned: 371 Modelled: 389 Confidence: 100.0% Identity: 36% PDB header:ligase Chain: B: PDB Molecule:cysteinyl-trna synthetase; PDBTitle: the 1.6 a crystal structure of mshc: the rate limiting2 enzyme in the mycothiol biosynthetic pathway Phyre2 PDB 3tqo chain A Region: 2 - 402 Aligned: 382 Modelled: 401 Confidence: 100.0% Identity: 56% PDB header:ligase Chain: A: PDB Molecule:cysteinyl-trna synthetase; PDBTitle: structure of the cysteinyl-trna synthetase (cyss) from coxiella2 burnetii. Phyre2 PDB 1li5 chain A domain 2 Region: 1 - 314 Aligned: 298 Modelled: 298 Confidence: 100.0% Identity: 100% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 2ct8 chain A Region: 18 - 412 Aligned: 386 Modelled: 389 Confidence: 100.0% Identity: 21% PDB header:ligase/rna Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: crystal structure of aquifex aeolicus methionyl-trna2 synthetase complexed with trna(met) and methionyl-adenylate3 anologue Phyre2 PDB 1rqg chain A Region: 24 - 411 Aligned: 386 Modelled: 388 Confidence: 100.0% Identity: 20% PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: methionyl-trna synthetase from pyrococcus abyssi Phyre2 PDB 1woy chain A Region: 24 - 404 Aligned: 378 Modelled: 381 Confidence: 100.0% Identity: 22% PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: crystal structure of methionyl trna synthetase y225f mutant2 from thermus thermophilus Phyre2 PDB 1pfu chain A Region: 20 - 413 Aligned: 391 Modelled: 393 Confidence: 100.0% Identity: 19% PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: methionyl-trna synthetase from escherichia coli complexed2 with methionine phosphinate Phyre2 PDB 2x1l chain C Region: 20 - 400 Aligned: 373 Modelled: 381 Confidence: 100.0% Identity: 21% PDB header:ligase Chain: C: PDB Molecule:methionyl-trna synthetase; PDBTitle: crystal structure of mycobacterium smegmatis methionyl-trna2 synthetase in complex with methionine and adenosine Phyre2 PDB 3kfl chain A Region: 21 - 402 Aligned: 379 Modelled: 382 Confidence: 100.0% Identity: 20% PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: leishmania major methionyl-trna synthetase in complex with2 methionyladenylate and pyrophosphate Phyre2 PDB 1rqg chain A domain 2 Region: 24 - 315 Aligned: 291 Modelled: 292 Confidence: 100.0% Identity: 19% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 3fnr chain A Region: 3 - 393 Aligned: 349 Modelled: 352 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: crystal structure of putative arginyl t-rna synthetase from2 campylobacter jejuni; Phyre2 PDB 1gax chain B Region: 15 - 430 Aligned: 415 Modelled: 416 Confidence: 100.0% Identity: 23% PDB header:ligase/rna Chain: B: PDB Molecule:valyl-trna synthetase; PDBTitle: crystal structure of thermus thermophilus valyl-trna2 synthetase complexed with trna(val) and valyl-adenylate3 analogue Phyre2 PDB 1ffy chain A domain 3 Region: 19 - 314 Aligned: 292 Modelled: 296 Confidence: 100.0% Identity: 24% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 1ile chain A Region: 19 - 430 Aligned: 411 Modelled: 412 Confidence: 100.0% Identity: 21% PDB header:aminoacyl-trna synthetase Chain: A: PDB Molecule:isoleucyl-trna synthetase; PDBTitle: isoleucyl-trna synthetase Phyre2 PDB 1pfv chain A domain 2 Region: 25 - 315 Aligned: 289 Modelled: 290 Confidence: 100.0% Identity: 21% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 1ivs chain A domain 4 Region: 11 - 314 Aligned: 299 Modelled: 304 Confidence: 100.0% Identity: 17% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 1wz2 chain B Region: 25 - 448 Aligned: 423 Modelled: 424 Confidence: 100.0% Identity: 19% PDB header:ligase/rna Chain: B: PDB Molecule:leucyl-trna synthetase; PDBTitle: the crystal structure of leucyl-trna synthetase and trna(leucine)2 complex Phyre2 PDB 1ile chain A domain 3 Region: 30 - 314 Aligned: 283 Modelled: 285 Confidence: 100.0% Identity: 19% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 1 c1u0bB_ 2 c3sp1B_ 3 c3c8zB_ 4 c3tqoA_ 5 d1li5a2 6 c2ct8A_ 7 c1rqgA_ 8 c1woyA_ 9 c1pfuA_ 10 c2x1lC_ 11 c3kflA_ 12 d1rqga2 13 c3fnrA_ 14 c1gaxB_ 15 d1ffya3 16 c1ileA_ 17 d1pfva2 18 d1ivsa4 19 c1wz2B_ 20 d1ilea3 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1u0bB_ 100.0 100 PDB header:ligase/rna Chain: B: PDB Molecule:cysteinyl trna; PDBTitle: crystal structure of cysteinyl-trna synthetase binary2 complex with trnacys 2 c3sp1B_ 100.0 33 PDB header:ligase Chain: B: PDB Molecule:cysteinyl-trna synthetase; PDBTitle: crystal structure of cysteinyl-trna synthetase (cyss) from borrelia2 burgdorferi 3 c3c8zB_ 100.0 36 PDB header:ligase Chain: B: PDB Molecule:cysteinyl-trna synthetase; PDBTitle: the 1.6 a crystal structure of mshc: the rate limiting2 enzyme in the mycothiol biosynthetic pathway 4 c3tqoA_ 100.0 56 PDB header:ligase Chain: A: PDB Molecule:cysteinyl-trna synthetase; PDBTitle: structure of the cysteinyl-trna synthetase (cyss) from coxiella2 burnetii. 5 d1li5a2 100.0 100 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 6 c2ct8A_ 100.0 21 PDB header:ligase/rna Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: crystal structure of aquifex aeolicus methionyl-trna2 synthetase complexed with trna(met) and methionyl-adenylate3 anologue 7 c1rqgA_ 100.0 20 PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: methionyl-trna synthetase from pyrococcus abyssi 8 c1woyA_ 100.0 22 PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: crystal structure of methionyl trna synthetase y225f mutant2 from thermus thermophilus 9 c1pfuA_ 100.0 19 PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: methionyl-trna synthetase from escherichia coli complexed2 with methionine phosphinate 10 c2x1lC_ 100.0 21 PDB header:ligase Chain: C: PDB Molecule:methionyl-trna synthetase; PDBTitle: crystal structure of mycobacterium smegmatis methionyl-trna2 synthetase in complex with methionine and adenosine 11 c3kflA_ 100.0 20 PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: leishmania major methionyl-trna synthetase in complex with2 methionyladenylate and pyrophosphate 12 d1rqga2 100.0 19 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 13 c3fnrA_ 100.0 18 PDB header:transferase Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: crystal structure of putative arginyl t-rna synthetase from2 campylobacter jejuni; 14 c1gaxB_ 100.0 23 PDB header:ligase/rna Chain: B: PDB Molecule:valyl-trna synthetase; PDBTitle: crystal structure of thermus thermophilus valyl-trna2 synthetase complexed with trna(val) and valyl-adenylate3 analogue 15 d1ffya3 100.0 24 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 16 c1ileA_ 100.0 21 PDB header:aminoacyl-trna synthetase Chain: A: PDB Molecule:isoleucyl-trna synthetase; PDBTitle: isoleucyl-trna synthetase 17 d1pfva2 100.0 21 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 18 d1ivsa4 100.0 17 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 19 c1wz2B_ 100.0 19 PDB header:ligase/rna Chain: B: PDB Molecule:leucyl-trna synthetase; PDBTitle: the crystal structure of leucyl-trna synthetase and trna(leucine)2 complex 20 d1ilea3 100.0 19 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 21 d1h3na3 not modelled 100.0 20 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 22 d2d5ba2 not modelled 100.0 23 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 23 c1qu2A_ not modelled 100.0 23 PDB header:ligase/rna Chain: A: PDB Molecule:isoleucyl-trna synthetase; PDBTitle: insights into editing from an ile-trna synthetase structure2 with trna(ile) and mupirocin 24 c1wkbA_ not modelled 100.0 22 PDB header:ligase Chain: A: PDB Molecule:leucyl-trna synthetase; PDBTitle: crystal structure of leucyl-trna synthetase from the2 archaeon pyrococcus horikoshii reveals a novel editing3 domain orientation 25 d1irxa2 not modelled 100.0 14 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 26 c1obhA_ not modelled 100.0 23 PDB header:synthetase Chain: A: PDB Molecule:leucyl-trna synthetase; PDBTitle: leucyl-trna synthetase from thermus thermophilus complexed2 with a pre-transfer editing substrate analogue in both3 synthetic active site and editing site 27 c1iq0A_ not modelled 100.0 20 PDB header:ligase Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: thermus thermophilus arginyl-trna synthetase 28 c2zufA_ not modelled 100.0 18 PDB header:ligase/rna Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: crystal structure of pyrococcus horikoshii arginyl-trna2 synthetase complexed with trna(arg) 29 d1f7ua2 not modelled 100.0 16 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 30 c1g59A_ not modelled 100.0 15 PDB header:ligase/rna Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: glutamyl-trna synthetase complexed with trna(glu). 31 d1gtra2 not modelled 100.0 16 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 32 c1f7uA_ not modelled 100.0 17 PDB header:ligase/rna Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: crystal structure of the arginyl-trna synthetase complexed with the2 trna(arg) and l-arg 33 d1iq0a2 not modelled 100.0 13 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 34 c3afhA_ not modelled 100.0 14 PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase 2; PDBTitle: crystal structure of thermotoga maritima nondiscriminating glutamyl-2 trna synthetase in complex with a glutamyl-amp analog 35 c2cfoA_ not modelled 100.0 17 PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: non-discriminating glutamyl-trna synthetase from2 thermosynechococcus elongatus in complex with glu 36 c1irxA_ not modelled 100.0 10 PDB header:ligase Chain: A: PDB Molecule:lysyl-trna synthetase; PDBTitle: crystal structure of class i lysyl-trna synthetase 37 c2ja2A_ not modelled 100.0 16 PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: mycobacterium tuberculosis glutamyl-trna synthetase 38 c2o5rA_ not modelled 100.0 15 PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase 1; PDBTitle: crystal structure of glutamyl-trna synthetase 1 (ec 6.1.1.17)2 (glutamate-trna ligase 1) (glurs 1) (tm1351) from thermotoga maritima3 at 2.5 a resolution 39 c1exdA_ not modelled 100.0 16 PDB header:ligase/rna Chain: A: PDB Molecule:glutaminyl-trna synthetase; PDBTitle: crystal structure of a tight-binding glutamine trna bound2 to glutamine aminoacyl trna synthetase 40 c3al0C_ not modelled 100.0 14 PDB header:ligase/rna Chain: C: PDB Molecule:glutamyl-trna(gln) amidotransferase subunit c, glutamyl- PDBTitle: crystal structure of the glutamine transamidosome from thermotoga2 maritima in the glutamylation state. 41 c2hz7A_ not modelled 99.9 16 PDB header:ligase Chain: A: PDB Molecule:glutaminyl-trna synthetase; PDBTitle: crystal structure of the glutaminyl-trna synthetase from2 deinococcus radiodurans 42 d1u0bb1 not modelled 99.9 100 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 43 d1j09a2 not modelled 99.9 15 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 44 c3aiiA_ not modelled 99.9 17 PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: archaeal non-discriminating glutamyl-trna synthetase from2 methanothermobacter thermautotrophicus 45 d1nzja_ not modelled 99.8 12 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 46 c2cybA_ not modelled 99.2 16 PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of tyrosyl-trna synthetase complexed with2 l-tyrosine from archaeoglobus fulgidus 47 d1li5a1 not modelled 99.0 100 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 48 c2cyaA_ not modelled 98.9 15 PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of tyrosyl-trna synthetase from aeropyrum pernix 49 c1h3eA_ not modelled 98.9 18 PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: tyrosyl-trna synthetase from thermus thermophilus complexed2 with wild-type trnatyr(gua) and with atp and tyrosinol 50 c2el7A_ not modelled 98.9 17 PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from thermus2 thermophilus 51 d1i6la_ not modelled 98.9 19 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 52 c3m5wB_ not modelled 98.8 15 PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from2 campylobacter jejuni 53 c3jxeB_ not modelled 98.8 16 PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of pyrococcus horikoshii tryptophanyl-trna2 synthetase in complex with trpamp 54 c2g36A_ not modelled 98.8 17 PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase (ec 6.1.1.2)2 (tryptophan-trna ligase)(trprs) (tm0492) from thermotoga maritima at3 2.50 a resolution 55 c2j5bA_ not modelled 98.8 16 PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: structure of the tyrosyl trna synthetase from acanthamoeba2 polyphaga mimivirus complexed with tyrosynol 56 c3prhB_ not modelled 98.7 17 PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase val144pro mutant from b. subtilis 57 d1h3fa1 not modelled 98.7 19 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 58 c3a05A_ not modelled 98.7 21 PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from2 hyperthermophilic archaeon, aeropyrum pernix k1 complex3 with tryptophan 59 c3hzrD_ not modelled 98.7 13 PDB header:ligase Chain: D: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase homolog from entamoeba histolytica 60 c1yi8C_ not modelled 98.6 17 PDB header:ligase Chain: C: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl trrna synthetase ii from deinococcus2 radiodurans in complex with l-trp 61 c2rkjM_ not modelled 98.5 14 PDB header:ligase/rna Chain: M: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: cocrystal structure of a tyrosyl-trna synthetase splicing2 factor with a group i intron rna 62 c3focB_ not modelled 98.5 15 PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase from giardia lamblia 63 c1jiiA_ not modelled 98.5 19 PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of s. aureus tyrrs in complex with sb-219383 64 d1jila_ not modelled 98.5 18 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 65 c2cycB_ not modelled 98.4 20 PDB header:ligase Chain: B: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of tyrosyl-trna synthetase complexed with l-tyrosine2 from pyrococcus horikoshii 66 c2quiB_ not modelled 98.3 18 PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structures of human tryptophanyl-trna synthetase in2 complex with tryptophanamide and atp 67 c2yy5C_ not modelled 98.3 16 PDB header:ligase Chain: C: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from mycoplasma2 pneumoniae 68 c1x8xA_ not modelled 98.3 16 PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: tyrosyl t-rna synthetase from e.coli complexed with tyrosine 69 c3p0jD_ not modelled 98.3 13 PDB header:ligase Chain: D: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: leishmania major tyrosyl-trna synthetase in complex with tyrosinol,2 triclinic crystal form 1 70 c2janD_ not modelled 98.3 14 PDB header:ligase Chain: D: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: tyrosyl-trna synthetase from mycobacterium tuberculosis in2 unliganded state 71 c3sz3A_ not modelled 98.2 18 PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from vibrio cholerae2 with an endogenous tryptophan 72 c2ts1A_ not modelled 98.1 17 PDB header:ligase (synthetase) Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: structure of tyrosyl-t/rna synthetase refined at 2.3 angstroms2 resolution. interaction of the enzyme with the tyrosyl adenylate3 intermediate 73 d2ts1a_ not modelled 98.1 17 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 74 c3n9iA_ not modelled 98.0 16 PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from yersinia pestis2 co92 75 d1r6ta2 not modelled 97.9 16 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 76 d1rqga1 not modelled 97.4 19 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 77 c2dlcX_ not modelled 97.3 11 PDB header:ligase/trna Chain: X: PDB Molecule:tyrosyl-trna synthetase, cytoplasmic; PDBTitle: crystal structure of the ternary complex of yeast tyrosyl-trna2 synthetase 78 c3hv0A_ not modelled 97.3 20 PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase from cryptosporidium parvum 79 d1j1ua_ not modelled 97.2 15 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 80 d2d5ba1 not modelled 96.9 19 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 81 d1n3la_ not modelled 96.9 12 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 82 c1q11A_ not modelled 96.8 10 PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of an active fragment of human tyrosyl-trna2 synthetase with tyrosinol 83 d1pfva1 not modelled 96.7 18 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 84 c3i05B_ not modelled 96.7 18 PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase from trypanosoma brucei 85 c1r6uB_ not modelled 96.0 21 PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of an active fragment of human tryptophanyl-trna2 synthetase with cytokine activity 86 c2ip1A_ not modelled 95.8 22 PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure analysis of s. cerevisiae tryptophanyl trna2 synthetase 87 c2pidB_ not modelled 94.9 16 PDB header:ligase Chain: B: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of human mitochondrial tyrosyl-trna synthetase in2 complex with an adenylate analog 88 d1iq0a1 not modelled 77.2 15 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 89 c2p6pB_ not modelled 71.2 18 PDB header:transferase Chain: B: PDB Molecule:glycosyl transferase; PDBTitle: x-ray crystal structure of c-c bond-forming dtdp-d-olivose-transferase2 urdgt2 90 d1pn3a_ not modelled 69.0 21 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:Gtf glycosyltransferase 91 d2cnda2 not modelled 67.2 16 Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:Reductases 92 c2iyaB_ not modelled 64.2 16 PDB header:transferase Chain: B: PDB Molecule:oleandomycin glycosyltransferase; PDBTitle: the crystal structure of macrolide glycosyltransferases: a2 blueprint for antibiotic engineering 93 d1iira_ not modelled 62.4 18 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:Gtf glycosyltransferase 94 d2pq6a1 not modelled 61.6 32 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:UDPGT-like 95 c2gk4A_ not modelled 60.9 17 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein; PDBTitle: the crystal structure of the dna/pantothenate metabolism flavoprotein2 from streptococcus pneumoniae 96 d1p9oa_ not modelled 57.9 13 Fold:Ribokinase-like Superfamily:CoaB-like Family:CoaB-like 97 d1f0ka_ not modelled 57.5 21 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:Peptidoglycan biosynthesis glycosyltransferase MurG 98 d1qx4a2 not modelled 57.3 18 Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:Reductases 99 d1rrva_ not modelled 54.6 18 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:Gtf glycosyltransferase 100 d1f7ua1 not modelled 53.9 21 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 101 d1u7za_ not modelled 52.9 15 Fold:Ribokinase-like Superfamily:CoaB-like Family:CoaB-like 102 c3hl4B_ not modelled 52.7 42 PDB header:transferase Chain: B: PDB Molecule:choline-phosphate cytidylyltransferase a; PDBTitle: crystal structure of a mammalian ctp:phosphocholine2 cytidylyltransferase with cdp-choline 103 d1x3za1 not modelled 51.6 24 Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:Transglutaminase core 104 c2x0dA_ not modelled 51.1 10 PDB header:transferase Chain: A: PDB Molecule:wsaf; PDBTitle: apo structure of wsaf 105 c3d0qB_ not modelled 50.6 22 PDB header:transferase Chain: B: PDB Molecule:protein calg3; PDBTitle: crystal structure of calg3 from micromonospora echinospora determined2 in space group i222 106 d1umka2 not modelled 47.9 18 Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:Reductases 107 c2bgjB_ not modelled 47.7 23 PDB header:oxidoreductase Chain: B: PDB Molecule:ferredoxin-nadp(h) reductase; PDBTitle: x-ray structure of the ferredoxin-nadp(h) reductase from2 rhodobacter capsulatus at 2.1 angstroms 108 c3eswA_ not modelled 47.5 24 PDB header:hydrolase Chain: A: PDB Molecule:peptide-n(4)-(n-acetyl-beta-glucosaminyl)asparagine PDBTitle: complex of yeast pngase with glcnac2-iac. 109 d1a8pa2 not modelled 45.7 26 Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:Reductases 110 c2yhsA_ not modelled 42.5 15 PDB header:cell cycle Chain: A: PDB Molecule:cell division protein ftsy; PDBTitle: structure of the e. coli srp receptor ftsy 111 c3ia7A_ not modelled 42.2 18 PDB header:transferase Chain: A: PDB Molecule:calg4; PDBTitle: crystal structure of calg4, the calicheamicin glycosyltransferase 112 c1yunB_ not modelled 42.1 16 PDB header:transferase Chain: B: PDB Molecule:probable nicotinate-nucleotide PDBTitle: crystal structure of nicotinic acid mononucleotide2 adenylyltransferase from pseudomonas aeruginosa 113 c1qzwC_ not modelled 38.0 23 PDB header:signaling protein/rna Chain: C: PDB Molecule:signal recognition 54 kda protein; PDBTitle: crystal structure of the complete core of archaeal srp and2 implications for inter-domain communication 114 d1ja1a3 not modelled 37.8 29 Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:NADPH-cytochrome p450 reductase-like 115 c2qy9A_ not modelled 37.3 15 PDB header:protein transport Chain: A: PDB Molecule:cell division protein ftsy; PDBTitle: structure of the ng+1 construct of the e. coli srp receptor2 ftsy 116 c3elbA_ not modelled 37.1 35 PDB header:transferase Chain: A: PDB Molecule:ethanolamine-phosphate cytidylyltransferase; PDBTitle: human ctp: phosphoethanolamine cytidylyltransferase in complex with2 cmp 117 c1a8pA_ not modelled 36.2 26 PDB header:oxidoreductase Chain: A: PDB Molecule:nadph\:ferredoxin oxidoreductase; PDBTitle: ferredoxin reductase from azotobacter vinelandii 118 d1k4ma_ not modelled 35.7 23 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Adenylyltransferase 119 d1kama_ not modelled 35.4 22 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Adenylyltransferase 120 d1qfja2 not modelled 35.0 16 Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:Reductases

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0