Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP00956
DateThu Jan 5 10:57:19 GMT 2012
Unique Job IDb75abc2e73f77b70

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c1qu2A_
Top template information
PDB header:ligase/rna
Chain: A: PDB Molecule:isoleucyl-trna synthetase;
PDBTitle: insights into editing from an ile-trna synthetase structure2 with trna(ile) and mupirocin
Confidence and coverage
Confidence:100.0% Coverage: 96%
904 residues ( 96% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MSDYKSTLNLPETGFPMRGDLAKREPGMLARWTDDDLYGIIRAAKKGKKTFILHDGPPYA
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Disorder  ???????


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   .........70.........80.........90.........100.........110.........120
Sequence  NGSIHIGHSVNKILKDIIVKSKGLSGYDSPYVPGWDCHGLPIELKVEQEYGKPGEKFTAA
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??????



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   .........130.........140.........150.........160.........170.........180
Sequence  EFRAKCREYAATQVDGQRKDFIRLGVLGDWSHPYLTMDFKTEANIIRALGKIIGNGHLHK
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   .........190.........200.........210.........220.........230.........240
Sequence  GAKPVHWCVDCRSALAEAEVEYYDKTSPSIDVAFQAVDQDALKAKFAVSNVNGPISLVIW
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   .........250.........260.........270.........280.........290.........300
Sequence  TTTPWTLPANRAISIAPDFDYALVQIDGQAVILAKDLVESVMQRIGVTDYTILGTVKGAE
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   .........310.........320.........330.........340.........350.........360
Sequence  LELLRFTHPFMGFDVPAILGDHVTLDAGTGAVHTAPGHGPDDYVIGQKYGLETANPVGPD
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   .........370.........380.........390.........400.........410.........420
Sequence  GTYLPGTYPTLDGVNVFKANDIVVALLQEKGALLHVEKMQHSYPCCWRHKTPIIFRATPQ
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   .........430.........440.........450.........460.........470.........480
Sequence  WFVSMDQKGLRAQSLKEIKGVQWIPDWGQARIESMVANRPDWCISRQRTWGVPMSLFVHK
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   .........490.........500.........510.........520.........530.........540
Sequence  DTEELHPRTLELMEEVAKRVEVDGIQAWWDLDAKEILGDEADQYVKVPDTLDVWFDSGST
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   .........550.........560.........570.........580.........590.........600
Sequence  HSSVVDVRPEFAGHAADMYLEGSDQHRGWFMSSLMISTAMKGKAPYRQVLTHGFTVDGQG
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   .........610.........620.........630.........640.........650.........660
Sequence  RKMSKSIGNTVSPQDVMNKLGADILRLWVASTDYTGEMAVSDEILKRAADSYRRIRNTAR
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   .........670.........680.........690.........700.........710.........720
Sequence  FLLANLNGFDPAKDMVKPEEMVVLDRWAVGCAKAAQEDILKAYEAYDFHEVVQRLMRFCS
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   .........730.........740.........750.........760.........770.........780
Sequence  VEMGSFYLDIIKDRQYTAKADSVARRSCQTALYHIAEALVRWMAPILSFTADEVWGYLPG
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?
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   .........790.........800.........810.........820.........830.........840
Sequence  EREKYVFTGEWYEGLFGLADSEAMNDAFWDELLKVRGEVNKVIEQARADKKVGGSLEAAV
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   .........850.........860.........870.........880.........890.........900
Sequence  TLYAEPELSAKLTALGDELRFVLLTSGATVADYNDAPADAQQSEVLKGLKVALSKAEGEK
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   .........910.........920.........930........
Sequence  CPRCWHYTQDVGKVAEHAEICGRCVSNVAGDGEKRKFA
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Disorder 








?
???????









??
???????
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1qu2 chain A

3D model

Region: 3 - 930
Aligned: 904
Modelled: 925
Confidence: 100.0%
Identity: 43%
PDB header:ligase/rna
Chain: A: PDB Molecule:isoleucyl-trna synthetase;
PDBTitle: insights into editing from an ile-trna synthetase structure2 with trna(ile) and mupirocin

Phyre2

PDB 1ile chain A

3D model

Region: 18 - 832
Aligned: 791
Modelled: 812
Confidence: 100.0%
Identity: 30%
PDB header:aminoacyl-trna synthetase
Chain: A: PDB Molecule:isoleucyl-trna synthetase;
PDBTitle: isoleucyl-trna synthetase

Phyre2

PDB 1gax chain B

3D model

Region: 14 - 878
Aligned: 768
Modelled: 792
Confidence: 100.0%
Identity: 24%
PDB header:ligase/rna
Chain: B: PDB Molecule:valyl-trna synthetase;
PDBTitle: crystal structure of thermus thermophilus valyl-trna2 synthetase complexed with trna(val) and valyl-adenylate3 analogue

Phyre2

PDB 1wz2 chain B

3D model

Region: 20 - 868
Aligned: 809
Modelled: 829
Confidence: 100.0%
Identity: 18%
PDB header:ligase/rna
Chain: B: PDB Molecule:leucyl-trna synthetase;
PDBTitle: the crystal structure of leucyl-trna synthetase and trna(leucine)2 complex

Phyre2

PDB 1wkb chain A

3D model

Region: 20 - 779
Aligned: 726
Modelled: 760
Confidence: 100.0%
Identity: 18%
PDB header:ligase
Chain: A: PDB Molecule:leucyl-trna synthetase;
PDBTitle: crystal structure of leucyl-trna synthetase from the2 archaeon pyrococcus horikoshii reveals a novel editing3 domain orientation

Phyre2

PDB 1obh chain A

3D model

Region: 18 - 801
Aligned: 678
Modelled: 702
Confidence: 100.0%
Identity: 21%
PDB header:synthetase
Chain: A: PDB Molecule:leucyl-trna synthetase;
PDBTitle: leucyl-trna synthetase from thermus thermophilus complexed2 with a pre-transfer editing substrate analogue in both3 synthetic active site and editing site

Phyre2

PDB 1ffy chain A domain 3

3D model

Region: 3 - 650
Aligned: 441
Modelled: 447
Confidence: 100.0%
Identity: 50%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2

PDB 1rqg chain A

3D model

Region: 49 - 829
Aligned: 542
Modelled: 551
Confidence: 100.0%
Identity: 23%
PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: methionyl-trna synthetase from pyrococcus abyssi

Phyre2

PDB 1h3n chain A domain 3

3D model

Region: 18 - 650
Aligned: 416
Modelled: 420
Confidence: 100.0%
Identity: 24%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2

PDB 1ile chain A domain 3

3D model

Region: 18 - 650
Aligned: 432
Modelled: 434
Confidence: 100.0%
Identity: 31%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2

PDB 1pfu chain A

3D model

Region: 48 - 818
Aligned: 519
Modelled: 537
Confidence: 100.0%
Identity: 20%
PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: methionyl-trna synthetase from escherichia coli complexed2 with methionine phosphinate

Phyre2

PDB 3kfl chain A

3D model

Region: 47 - 795
Aligned: 486
Modelled: 495
Confidence: 100.0%
Identity: 19%
PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: leishmania major methionyl-trna synthetase in complex with2 methionyladenylate and pyrophosphate

Phyre2

PDB 1woy chain A

3D model

Region: 48 - 802
Aligned: 480
Modelled: 492
Confidence: 100.0%
Identity: 23%
PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: crystal structure of methionyl trna synthetase y225f mutant2 from thermus thermophilus

Phyre2

PDB 1ivs chain A domain 4

3D model

Region: 14 - 651
Aligned: 416
Modelled: 419
Confidence: 100.0%
Identity: 27%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2

PDB 2x1l chain C

3D model

Region: 49 - 796
Aligned: 447
Modelled: 453
Confidence: 100.0%
Identity: 26%
PDB header:ligase
Chain: C: PDB Molecule:methionyl-trna synthetase;
PDBTitle: crystal structure of mycobacterium smegmatis methionyl-trna2 synthetase in complex with methionine and adenosine

Phyre2

PDB 2ct8 chain A

3D model

Region: 49 - 800
Aligned: 443
Modelled: 458
Confidence: 100.0%
Identity: 24%
PDB header:ligase/rna
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: crystal structure of aquifex aeolicus methionyl-trna2 synthetase complexed with trna(met) and methionyl-adenylate3 anologue

Phyre2

PDB 1ffy chain A domain 1

3D model

Region: 652 - 930
Aligned: 270
Modelled: 279
Confidence: 100.0%
Identity: 35%
Fold: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases

Phyre2

PDB 1rqg chain A domain 2

3D model

Region: 49 - 650
Aligned: 345
Modelled: 350
Confidence: 100.0%
Identity: 26%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2

PDB 2d5b chain A domain 2

3D model

Region: 48 - 651
Aligned: 338
Modelled: 341
Confidence: 100.0%
Identity: 26%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2

PDB 1pfv chain A domain 2

3D model

Region: 48 - 654
Aligned: 332
Modelled: 338
Confidence: 100.0%
Identity: 27%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2
1

c1qu2A_
2

c1ileA_
3

c1gaxB_
4

c1wz2B_
5

c1wkbA_
6

c1obhA_
7

d1ffya3
8

c1rqgA_
9

d1h3na3
10

d1ilea3
11

c1pfuA_
12

c3kflA_
13

c1woyA_
14

d1ivsa4
15

c2x1lC_
16

c2ct8A_
17

d1ffya1
18

d1rqga2
19

d2d5ba2
20

d1pfva2
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c1qu2A_



100.0 43 PDB header:ligase/rna
Chain: A: PDB Molecule:isoleucyl-trna synthetase;
PDBTitle: insights into editing from an ile-trna synthetase structure2 with trna(ile) and mupirocin
2c1ileA_



100.0 30 PDB header:aminoacyl-trna synthetase
Chain: A: PDB Molecule:isoleucyl-trna synthetase;
PDBTitle: isoleucyl-trna synthetase
3c1gaxB_



100.0 24 PDB header:ligase/rna
Chain: B: PDB Molecule:valyl-trna synthetase;
PDBTitle: crystal structure of thermus thermophilus valyl-trna2 synthetase complexed with trna(val) and valyl-adenylate3 analogue
4c1wz2B_



100.0 18 PDB header:ligase/rna
Chain: B: PDB Molecule:leucyl-trna synthetase;
PDBTitle: the crystal structure of leucyl-trna synthetase and trna(leucine)2 complex
5c1wkbA_



100.0 18 PDB header:ligase
Chain: A: PDB Molecule:leucyl-trna synthetase;
PDBTitle: crystal structure of leucyl-trna synthetase from the2 archaeon pyrococcus horikoshii reveals a novel editing3 domain orientation
6c1obhA_



100.0 21 PDB header:synthetase
Chain: A: PDB Molecule:leucyl-trna synthetase;
PDBTitle: leucyl-trna synthetase from thermus thermophilus complexed2 with a pre-transfer editing substrate analogue in both3 synthetic active site and editing site
7d1ffya3



100.0 50 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
8c1rqgA_



100.0 23 PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: methionyl-trna synthetase from pyrococcus abyssi
9d1h3na3



100.0 24 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
10d1ilea3



100.0 31 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
11c1pfuA_



100.0 20 PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: methionyl-trna synthetase from escherichia coli complexed2 with methionine phosphinate
12c3kflA_



100.0 19 PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: leishmania major methionyl-trna synthetase in complex with2 methionyladenylate and pyrophosphate
13c1woyA_



100.0 23 PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: crystal structure of methionyl trna synthetase y225f mutant2 from thermus thermophilus
14d1ivsa4



100.0 27 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
15c2x1lC_



100.0 26 PDB header:ligase
Chain: C: PDB Molecule:methionyl-trna synthetase;
PDBTitle: crystal structure of mycobacterium smegmatis methionyl-trna2 synthetase in complex with methionine and adenosine
16c2ct8A_



100.0 24 PDB header:ligase/rna
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: crystal structure of aquifex aeolicus methionyl-trna2 synthetase complexed with trna(met) and methionyl-adenylate3 anologue
17d1ffya1



100.0 35 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
18d1rqga2



100.0 26 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
19d2d5ba2



100.0 26 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
20d1pfva2



100.0 27 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
21d1qu3a1



not modelled 100.0 33 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
22c1u0bB_



not modelled 100.0 26 PDB header:ligase/rna
Chain: B: PDB Molecule:cysteinyl trna;
PDBTitle: crystal structure of cysteinyl-trna synthetase binary2 complex with trnacys
23d1udza_



not modelled 100.0 34 Fold:ValRS/IleRS/LeuRS editing domain
Superfamily:ValRS/IleRS/LeuRS editing domain
Family:ValRS/IleRS/LeuRS editing domain
24d1ffya2



not modelled 100.0 41 Fold:ValRS/IleRS/LeuRS editing domain
Superfamily:ValRS/IleRS/LeuRS editing domain
Family:ValRS/IleRS/LeuRS editing domain
25c3tqoA_



not modelled 100.0 20 PDB header:ligase
Chain: A: PDB Molecule:cysteinyl-trna synthetase;
PDBTitle: structure of the cysteinyl-trna synthetase (cyss) from coxiella2 burnetii.
26c3c8zB_



not modelled 100.0 21 PDB header:ligase
Chain: B: PDB Molecule:cysteinyl-trna synthetase;
PDBTitle: the 1.6 a crystal structure of mshc: the rate limiting2 enzyme in the mycothiol biosynthetic pathway
27d1h3na2



not modelled 100.0 24 Fold:ValRS/IleRS/LeuRS editing domain
Superfamily:ValRS/IleRS/LeuRS editing domain
Family:ValRS/IleRS/LeuRS editing domain
28c3sp1B_



not modelled 100.0 18 PDB header:ligase
Chain: B: PDB Molecule:cysteinyl-trna synthetase;
PDBTitle: crystal structure of cysteinyl-trna synthetase (cyss) from borrelia2 burgdorferi
29c3fnrA_



not modelled 100.0 16 PDB header:transferase
Chain: A: PDB Molecule:arginyl-trna synthetase;
PDBTitle: crystal structure of putative arginyl t-rna synthetase from2 campylobacter jejuni;
30c3o0aB_



not modelled 100.0 23 PDB header:ligase
Chain: B: PDB Molecule:leucyl-trna synthetase subunit alpha;
PDBTitle: crystal structure of the wild type cp1 hydrolitic domain from aquifex2 aeolicus leucyl-trna
31c2wfdB_



not modelled 100.0 18 PDB header:ligase
Chain: B: PDB Molecule:leucyl-trna synthetase, cytoplasmic;
PDBTitle: structure of the human cytosolic leucyl-trna synthetase2 editing domain
32c2wfgA_



not modelled 100.0 21 PDB header:ligase
Chain: A: PDB Molecule:cytosolic leucyl-trna synthetase;
PDBTitle: structure of the candida albicans cytosolic leucyl-trna2 synthetase editing domain bound to a benzoxaborole-amp3 adduct
33d1wkaa1



not modelled 100.0 28 Fold:ValRS/IleRS/LeuRS editing domain
Superfamily:ValRS/IleRS/LeuRS editing domain
Family:ValRS/IleRS/LeuRS editing domain
34c2ajhA_



not modelled 100.0 22 PDB header:ligase
Chain: A: PDB Molecule:leucyl-trna synthetase;
PDBTitle: crystal structure of the editing domain of e. coli leucyl-2 trna synthetase complexes with methionine
35d1ivsa2



not modelled 100.0 19 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
36d1li5a2



not modelled 100.0 28 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
37c1iq0A_



not modelled 100.0 18 PDB header:ligase
Chain: A: PDB Molecule:arginyl-trna synthetase;
PDBTitle: thermus thermophilus arginyl-trna synthetase
38c3pz6F_



not modelled 100.0 19 PDB header:ligase
Chain: F: PDB Molecule:leucyl-trna synthetase;
PDBTitle: the crystal structure of glleurs-cp1
39d1ilea1



not modelled 100.0 23 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
40c2zufA_



not modelled 99.9 22 PDB header:ligase/rna
Chain: A: PDB Molecule:arginyl-trna synthetase;
PDBTitle: crystal structure of pyrococcus horikoshii arginyl-trna2 synthetase complexed with trna(arg)
41d1iq0a2



not modelled 99.9 17 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
42d1irxa2



not modelled 99.9 18 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
43d1f7ua2



not modelled 99.9 20 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
44d1h3na1



not modelled 99.8 18 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
45c1f7uA_



not modelled 99.8 20 PDB header:ligase/rna
Chain: A: PDB Molecule:arginyl-trna synthetase;
PDBTitle: crystal structure of the arginyl-trna synthetase complexed with the2 trna(arg) and l-arg
46d1rqga1



not modelled 99.8 18 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
47c1g59A_



not modelled 99.7 16 PDB header:ligase/rna
Chain: A: PDB Molecule:glutamyl-trna synthetase;
PDBTitle: glutamyl-trna synthetase complexed with trna(glu).
48d1pfva1



not modelled 99.6 15 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
49c2ja2A_



not modelled 99.6 19 PDB header:ligase
Chain: A: PDB Molecule:glutamyl-trna synthetase;
PDBTitle: mycobacterium tuberculosis glutamyl-trna synthetase
50d2d5ba1



not modelled 99.5 13 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
51c2cfoA_



not modelled 99.5 18 PDB header:ligase
Chain: A: PDB Molecule:glutamyl-trna synthetase;
PDBTitle: non-discriminating glutamyl-trna synthetase from2 thermosynechococcus elongatus in complex with glu
52c3afhA_



not modelled 99.4 17 PDB header:ligase
Chain: A: PDB Molecule:glutamyl-trna synthetase 2;
PDBTitle: crystal structure of thermotoga maritima nondiscriminating glutamyl-2 trna synthetase in complex with a glutamyl-amp analog
53c2o5rA_



not modelled 99.4 20 PDB header:ligase
Chain: A: PDB Molecule:glutamyl-trna synthetase 1;
PDBTitle: crystal structure of glutamyl-trna synthetase 1 (ec 6.1.1.17)2 (glutamate-trna ligase 1) (glurs 1) (tm1351) from thermotoga maritima3 at 2.5 a resolution
54c1irxA_



not modelled 99.1 18 PDB header:ligase
Chain: A: PDB Molecule:lysyl-trna synthetase;
PDBTitle: crystal structure of class i lysyl-trna synthetase
55d1gtra2



not modelled 98.3 24 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
56c3aiiA_



not modelled 98.2 25 PDB header:ligase
Chain: A: PDB Molecule:glutamyl-trna synthetase;
PDBTitle: archaeal non-discriminating glutamyl-trna synthetase from2 methanothermobacter thermautotrophicus
57c1exdA_



not modelled 98.2 23 PDB header:ligase/rna
Chain: A: PDB Molecule:glutaminyl-trna synthetase;
PDBTitle: crystal structure of a tight-binding glutamine trna bound2 to glutamine aminoacyl trna synthetase
58c2hz7A_



not modelled 98.1 28 PDB header:ligase
Chain: A: PDB Molecule:glutaminyl-trna synthetase;
PDBTitle: crystal structure of the glutaminyl-trna synthetase from2 deinococcus radiodurans
59d1nzja_



not modelled 98.1 15 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
60d1j09a2



not modelled 98.0 15 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
61c1jiiA_



not modelled 97.8 27 PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: crystal structure of s. aureus tyrrs in complex with sb-219383
62c1h3eA_



not modelled 97.7 28 PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: tyrosyl-trna synthetase from thermus thermophilus complexed2 with wild-type trnatyr(gua) and with atp and tyrosinol
63d1jila_



not modelled 97.7 27 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
64c2janD_



not modelled 97.7 23 PDB header:ligase
Chain: D: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: tyrosyl-trna synthetase from mycobacterium tuberculosis in2 unliganded state
65c2cybA_



not modelled 97.7 32 PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: crystal structure of tyrosyl-trna synthetase complexed with2 l-tyrosine from archaeoglobus fulgidus
66c3al0C_



not modelled 97.6 20 PDB header:ligase/rna
Chain: C: PDB Molecule:glutamyl-trna(gln) amidotransferase subunit c, glutamyl-
PDBTitle: crystal structure of the glutamine transamidosome from thermotoga2 maritima in the glutamylation state.
67d1h3fa1



not modelled 97.4 21 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
68c2j5bA_



not modelled 97.4 19 PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: structure of the tyrosyl trna synthetase from acanthamoeba2 polyphaga mimivirus complexed with tyrosynol
69c1x8xA_



not modelled 97.3 25 PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: tyrosyl t-rna synthetase from e.coli complexed with tyrosine
70c2ts1A_



not modelled 97.1 24 PDB header:ligase (synthetase)
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: structure of tyrosyl-t/rna synthetase refined at 2.3 angstroms2 resolution. interaction of the enzyme with the tyrosyl adenylate3 intermediate
71d2ts1a_



not modelled 97.1 24 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
72c2rkjM_



not modelled 97.0 30 PDB header:ligase/rna
Chain: M: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: cocrystal structure of a tyrosyl-trna synthetase splicing2 factor with a group i intron rna
73c2el7A_



not modelled 97.0 20 PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from thermus2 thermophilus
74c2cyaA_



not modelled 96.9 30 PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: crystal structure of tyrosyl-trna synthetase from aeropyrum pernix
75c2g36A_



not modelled 96.9 25 PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase (ec 6.1.1.2)2 (tryptophan-trna ligase)(trprs) (tm0492) from thermotoga maritima at3 2.50 a resolution
76c3a05A_



not modelled 96.4 25 PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from2 hyperthermophilic archaeon, aeropyrum pernix k1 complex3 with tryptophan
77c2cycB_



not modelled 96.2 28 PDB header:ligase
Chain: B: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: crystal structure of tyrosyl-trna synthetase complexed with l-tyrosine2 from pyrococcus horikoshii
78c3prhB_



not modelled 95.9 17 PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: tryptophanyl-trna synthetase val144pro mutant from b. subtilis
79c3hzrD_



not modelled 95.9 9 PDB header:ligase
Chain: D: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: tryptophanyl-trna synthetase homolog from entamoeba histolytica
80c3n9iA_



not modelled 95.9 18 PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from yersinia pestis2 co92
81c3m5wB_



not modelled 95.8 22 PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from2 campylobacter jejuni
82c2yy5C_



not modelled 95.4 18 PDB header:ligase
Chain: C: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from mycoplasma2 pneumoniae
83c2quiB_



not modelled 95.4 23 PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structures of human tryptophanyl-trna synthetase in2 complex with tryptophanamide and atp
84c1yi8C_



not modelled 95.3 25 PDB header:ligase
Chain: C: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl trrna synthetase ii from deinococcus2 radiodurans in complex with l-trp
85d1n3la_



not modelled 94.8 14 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
86c3hv0A_



not modelled 94.8 19 PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: tryptophanyl-trna synthetase from cryptosporidium parvum
87d1i6la_



not modelled 94.5 18 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
88c3focB_



not modelled 94.3 16 PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: tryptophanyl-trna synthetase from giardia lamblia
89c3p0jD_



not modelled 94.3 26 PDB header:ligase
Chain: D: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: leishmania major tyrosyl-trna synthetase in complex with tyrosinol,2 triclinic crystal form 1
90c3jxeB_



not modelled 93.9 19 PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of pyrococcus horikoshii tryptophanyl-trna2 synthetase in complex with trpamp
91d1j1ua_



not modelled 92.8 20 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
92c2dlcX_



not modelled 92.8 10 PDB header:ligase/trna
Chain: X: PDB Molecule:tyrosyl-trna synthetase, cytoplasmic;
PDBTitle: crystal structure of the ternary complex of yeast tyrosyl-trna2 synthetase
93c3sz3A_



not modelled 92.5 25 PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from vibrio cholerae2 with an endogenous tryptophan
94d1r6ta2



not modelled 90.5 20 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
95c1q11A_



not modelled 90.5 9 PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: crystal structure of an active fragment of human tyrosyl-trna2 synthetase with tyrosinol
96c3i05B_



not modelled 90.2 13 PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: tryptophanyl-trna synthetase from trypanosoma brucei
97c2pidB_



not modelled 89.0 21 PDB header:ligase
Chain: B: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: crystal structure of human mitochondrial tyrosyl-trna synthetase in2 complex with an adenylate analog
98c2ip1A_



not modelled 87.2 21 PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure analysis of s. cerevisiae tryptophanyl trna2 synthetase
99c1r6uB_



not modelled 85.6 18 PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of an active fragment of human tryptophanyl-trna2 synthetase with cytokine activity
100d1iq0a1



not modelled 60.1 13 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
101d2ey4e1



not modelled 56.6 53 Fold:Rubredoxin-like
Superfamily:Nop10-like SnoRNP
Family:Nucleolar RNA-binding protein Nop10-like
102d2apob1



not modelled 49.0 59 Fold:Rubredoxin-like
Superfamily:Nop10-like SnoRNP
Family:Nucleolar RNA-binding protein Nop10-like
103d1zt2a1



not modelled 46.1 13 Fold:Prim-pol domain
Superfamily:Prim-pol domain
Family:PriA-like
104d1f7ua1



not modelled 45.4 15 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
105c2k42A_



not modelled 44.0 22 PDB header:signaling protein
Chain: A: PDB Molecule:wiskott-aldrich syndrome protein;
PDBTitle: solution structure of the gtpase binding domain of wasp in2 complex with espfu, an ehec effector
106d1imla2



not modelled 42.8 37 Fold:Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:Glucocorticoid receptor-like (DNA-binding domain)
Family:LIM domain
107c2opfA_



not modelled 41.1 27 PDB header:hydrolase/dna
Chain: A: PDB Molecule:endonuclease viii;
PDBTitle: crystal structure of the dna repair enzyme endonuclease-viii (nei)2 from e. coli (r252a) in complex with ap-site containing dna substrate
108c1k82D_



not modelled 40.1 13 PDB header:hydrolase/dna
Chain: D: PDB Molecule:formamidopyrimidine-dna glycosylase;
PDBTitle: crystal structure of e.coli formamidopyrimidine-dna2 glycosylase (fpg) covalently trapped with dna
109d1vdda_



not modelled 40.1 40 Fold:Recombination protein RecR
Superfamily:Recombination protein RecR
Family:Recombination protein RecR
110c1nnjA_



not modelled 38.3 18 PDB header:hydrolase
Chain: A: PDB Molecule:formamidopyrimidine-dna glycosylase;
PDBTitle: crystal structure complex between the lactococcus lactis fpg and an2 abasic site containing dna
111c3bmaC_



not modelled 38.3 24 PDB header:ligase
Chain: C: PDB Molecule:d-alanyl-lipoteichoic acid synthetase;
PDBTitle: crystal structure of d-alanyl-lipoteichoic acid synthetase from2 streptococcus pneumoniae r6
112d1ibia1



not modelled 37.8 83 Fold:Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:Glucocorticoid receptor-like (DNA-binding domain)
Family:LIM domain
113c1vddC_



not modelled 37.0 40 PDB header:recombination
Chain: C: PDB Molecule:recombination protein recr;
PDBTitle: crystal structure of recombinational repair protein recr
114c1yuzB_



not modelled 35.0 33 PDB header:oxidoreductase
Chain: B: PDB Molecule:nigerythrin;
PDBTitle: partially reduced state of nigerythrin
115d1k3xa3



not modelled 34.5 27 Fold:Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:Glucocorticoid receptor-like (DNA-binding domain)
Family:C-terminal, Zn-finger domain of MutM-like DNA repair proteins
116d1v8fa_



not modelled 33.6 13 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)
117c1ee8A_



not modelled 32.8 19 PDB header:dna binding protein
Chain: A: PDB Molecule:mutm (fpg) protein;
PDBTitle: crystal structure of mutm (fpg) protein from thermus thermophilus hb8
118c2f5qA_



not modelled 30.8 14 PDB header:hydrolase/dna
Chain: A: PDB Molecule:formamidopyrimidine-dna glycosidase;
PDBTitle: catalytically inactive (e3q) mutm crosslinked to oxog:c2 containing dna cc2
119c3a46B_



not modelled 28.7 8 PDB header:hydrolase
Chain: B: PDB Molecule:formamidopyrimidine-dna glycosylase;
PDBTitle: crystal structure of mvnei1/thf complex
120d1ctla1



not modelled 28.2 57 Fold:Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:Glucocorticoid receptor-like (DNA-binding domain)
Family:LIM domain

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0