Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	Q	Y	S	S	L	L	R	G	L	A	A	G	S	A	F	L	F	L	F	A	P	T	A	F	A	A	E	Q	T	V	E	A	P	S	V	D	A	R	A	W	I	L	M	D	Y	A	S	G	K	V	L	A	E	G	N	A	D	E
Secondary structure
SS confidence
Disorder		?	?	?	?																		?	?	?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	L	D	P	A	S	L	T	K	I	M	T	S	Y	V	V	G	Q	A	L	K	A	D	K	I	K	L	T	D	M	V	T	V	G	K	D	A	W	A	T	G	N	P	A	L	R	G	S	S	V	M	F	L	K	P	G	D	Q	V	S
Secondary structure
SS confidence
Disorder																								?	?																?	?	?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	A	D	L	N	K	G	V	I	I	Q	S	G	N	D	A	C	I	A	L	A	D	Y	V	A	G	S	Q	E	S	F	I	G	L	M	N	G	Y	A	K	K	L	G	L	T	N	T	T	F	Q	T	V	H	G	L	D	A	P	G	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	S	T	A	R	D	M	A	L	L	G	K	A	L	I	H	D	V	P	E	E	Y	A	I	H	K	E	K	E	F	T	F	N	K	I	R	Q	P	N	R	N	R	L	L	W	S	S	N	L	N	V	D	G	M	K	T	G	T	T	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	A	G	Y	N	L	V	A	S	A	T	Q	G	D	M	R	L	I	S	V	V	L	G	A	K	T	D	R	I	R	F	N	E	S	E	K	L	L	T	W	G	F	R	F	F	E	T	V	T	P	I	K	P	D	A	T	F	V	T	Q
Secondary structure
SS confidence
Disorder																																																					?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		R	V	W	F	G	D	K	S	E	V	N	L	G	A	G	E	A	G	S	V	T	I	P	R	G	Q	L	K	N	L	K	A	S	Y	T	L	T	E	P	Q	L	T	A	P	L	K	K	G	Q	V	V	G	T	I	D	F	Q	L	N	G
Secondary structure
SS confidence
Disorder																																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400
Sequence		K	S	I	E	Q	R	P	L	I	V	M	E	N	V	E	E	G	G	F	F	G	R	V	W	D	F	V	M	M	K	F	H	Q	W	F	G	S	W	F	S
Secondary structure
SS confidence
Disorder																		?																							?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3it9 chain B Region: 34 - 378 Aligned: 345 Modelled: 345 Confidence: 100.0% Identity: 100% PDB header:hydrolase Chain: B: PDB Molecule:d-alanyl-d-alanine carboxypeptidase dacc; PDBTitle: crystal structure of penicillin-binding protein 6 (pbp6)2 from e. coli in apo state Phyre2 PDB 1z6f chain A Region: 28 - 379 Aligned: 352 Modelled: 352 Confidence: 100.0% Identity: 64% PDB header:hydrolase Chain: A: PDB Molecule:penicillin-binding protein 5; PDBTitle: crystal structure of penicillin-binding protein 5 from e. coli in2 complex with a boronic acid inhibitor Phyre2 PDB 3a3j chain A Region: 31 - 376 Aligned: 343 Modelled: 346 Confidence: 100.0% Identity: 54% PDB header:hydrolase Chain: A: PDB Molecule:pbp5; PDBTitle: crystal structures of penicillin binding protein 5 from2 haemophilus influenzae Phyre2 PDB 1xp4 chain C Region: 36 - 373 Aligned: 325 Modelled: 335 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: C: PDB Molecule:d-alanyl-d-alanine carboxypeptidase; PDBTitle: crystal structure of a peptidoglycan synthesis regulatory2 factor (pbp3) from streptococcus pneumoniae Phyre2 PDB 3mfd chain B Region: 36 - 371 Aligned: 301 Modelled: 336 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: B: PDB Molecule:d-alanyl-d-alanine carboxypeptidase dacb; PDBTitle: the structure of the beta-lactamase superfamily domain of d-alanyl-d-2 alanine carboxypeptidase from bacillus subtilis Phyre2 PDB 1tvf chain A Region: 22 - 349 Aligned: 326 Modelled: 328 Confidence: 100.0% Identity: 24% PDB header:penicillin binding Chain: A: PDB Molecule:penicillin binding protein 4; PDBTitle: crystal structure of penicillin-binding protein 4 (pbp4)2 from staphylococcus aureus Phyre2 PDB 3hum chain B Region: 22 - 346 Aligned: 322 Modelled: 325 Confidence: 100.0% Identity: 24% PDB header:hydrolase/antibiotics Chain: B: PDB Molecule:penicillin-binding protein 4; PDBTitle: crystal structure of penicillin binding protein 4 from2 staphylococcus aureus col in complex with cefotaxime Phyre2 PDB 1tvf chain A domain 2 Region: 22 - 285 Aligned: 262 Modelled: 264 Confidence: 100.0% Identity: 28% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 3bec chain A domain 2 Region: 28 - 283 Aligned: 256 Modelled: 256 Confidence: 100.0% Identity: 67% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 1xp4 chain A domain 2 Region: 36 - 285 Aligned: 247 Modelled: 250 Confidence: 100.0% Identity: 28% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 2bcf chain A Region: 26 - 290 Aligned: 251 Modelled: 265 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:probable d-alanyl-d-alanine carboxypeptidase PDBTitle: crystal structure of a evolved putative penicillin-binding2 protein homolog, rv2911, from mycobacterium tuberculosis. Phyre2 PDB 1es5 chain A Region: 35 - 283 Aligned: 242 Modelled: 249 Confidence: 100.0% Identity: 33% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 2v20 chain A Region: 41 - 285 Aligned: 233 Modelled: 240 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase tem; PDBTitle: structure of a tem-1 beta-lactamase insertant2 allosterically regulated by kanamycin and anions. complex3 with sulfate. Phyre2 PDB 1m40 chain A Region: 41 - 285 Aligned: 233 Modelled: 240 Confidence: 100.0% Identity: 16% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 1n9b chain A Region: 41 - 286 Aligned: 234 Modelled: 246 Confidence: 100.0% Identity: 19% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 2j7v chain A Region: 41 - 286 Aligned: 234 Modelled: 241 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:tll2115 protein; PDBTitle: structure of pbp-a Phyre2 PDB 3qhy chain A Region: 41 - 286 Aligned: 231 Modelled: 246 Confidence: 100.0% Identity: 16% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:beta-lactamase; PDBTitle: structural, thermodynamic and kinetic analysis of the picomolar2 binding affinity interaction of the beta-lactamase inhibitor protein-3 ii (blip-ii) with class a beta-lactamases Phyre2 PDB 1dy6 chain A Region: 41 - 286 Aligned: 235 Modelled: 242 Confidence: 100.0% Identity: 15% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 1o7e chain A Region: 41 - 282 Aligned: 229 Modelled: 242 Confidence: 100.0% Identity: 19% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 3cg5 chain A Region: 41 - 270 Aligned: 219 Modelled: 230 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of the covalent adduct formed between tb2 b-lactamase and clavulanate Phyre2 1 c3it9B_ 2 c1z6fA_ 3 c3a3jA_ 4 c1xp4C_ 5 c3mfdB_ 6 c1tvfA_ 7 c3humB_ 8 d1tvfa2 9 d3beca2 10 d1xp4a2 11 c2bcfA_ 12 d1es5a_ 13 c2v20A_ 14 d1m40a_ 15 d1n9ba_ 16 c2j7vA_ 17 c3qhyA_ 18 d1dy6a_ 19 d1o7ea_ 20 c3cg5A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3it9B_ 100.0 100 PDB header:hydrolase Chain: B: PDB Molecule:d-alanyl-d-alanine carboxypeptidase dacc; PDBTitle: crystal structure of penicillin-binding protein 6 (pbp6)2 from e. coli in apo state 2 c1z6fA_ 100.0 64 PDB header:hydrolase Chain: A: PDB Molecule:penicillin-binding protein 5; PDBTitle: crystal structure of penicillin-binding protein 5 from e. coli in2 complex with a boronic acid inhibitor 3 c3a3jA_ 100.0 54 PDB header:hydrolase Chain: A: PDB Molecule:pbp5; PDBTitle: crystal structures of penicillin binding protein 5 from2 haemophilus influenzae 4 c1xp4C_ 100.0 25 PDB header:hydrolase Chain: C: PDB Molecule:d-alanyl-d-alanine carboxypeptidase; PDBTitle: crystal structure of a peptidoglycan synthesis regulatory2 factor (pbp3) from streptococcus pneumoniae 5 c3mfdB_ 100.0 31 PDB header:hydrolase Chain: B: PDB Molecule:d-alanyl-d-alanine carboxypeptidase dacb; PDBTitle: the structure of the beta-lactamase superfamily domain of d-alanyl-d-2 alanine carboxypeptidase from bacillus subtilis 6 c1tvfA_ 100.0 24 PDB header:penicillin binding Chain: A: PDB Molecule:penicillin binding protein 4; PDBTitle: crystal structure of penicillin-binding protein 4 (pbp4)2 from staphylococcus aureus 7 c3humB_ 100.0 24 PDB header:hydrolase/antibiotics Chain: B: PDB Molecule:penicillin-binding protein 4; PDBTitle: crystal structure of penicillin binding protein 4 from2 staphylococcus aureus col in complex with cefotaxime 8 d1tvfa2 100.0 28 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 9 d3beca2 100.0 67 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 10 d1xp4a2 100.0 28 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 11 c2bcfA_ 100.0 30 PDB header:hydrolase Chain: A: PDB Molecule:probable d-alanyl-d-alanine carboxypeptidase PDBTitle: crystal structure of a evolved putative penicillin-binding2 protein homolog, rv2911, from mycobacterium tuberculosis. 12 d1es5a_ 100.0 33 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 13 c2v20A_ 100.0 15 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase tem; PDBTitle: structure of a tem-1 beta-lactamase insertant2 allosterically regulated by kanamycin and anions. complex3 with sulfate. 14 d1m40a_ 100.0 16 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 15 d1n9ba_ 100.0 19 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 16 c2j7vA_ 100.0 16 PDB header:hydrolase Chain: A: PDB Molecule:tll2115 protein; PDBTitle: structure of pbp-a 17 c3qhyA_ 100.0 16 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:beta-lactamase; PDBTitle: structural, thermodynamic and kinetic analysis of the picomolar2 binding affinity interaction of the beta-lactamase inhibitor protein-3 ii (blip-ii) with class a beta-lactamases 18 d1dy6a_ 100.0 15 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 19 d1o7ea_ 100.0 19 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 20 c3cg5A_ 100.0 16 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of the covalent adduct formed between tb2 b-lactamase and clavulanate 21 c3dw0B_ not modelled 100.0 19 PDB header:hydrolase Chain: B: PDB Molecule:class a carbapenemase kpc-2; PDBTitle: crystal structure of the class a carbapenemase kpc-2 at 1.62 angstrom resolution 22 d1hzoa_ not modelled 100.0 18 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 23 c3p09B_ not modelled 100.0 15 PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of beta-lactamase from francisella tularensis 24 c1i2sA_ not modelled 100.0 15 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: beta-lactamase from bacillus licheniformis bs3 25 d1i2sa_ not modelled 100.0 15 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 26 d1iysa_ not modelled 100.0 21 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 27 c3cjmA_ not modelled 100.0 13 PDB header:hydrolase Chain: A: PDB Molecule:putative beta-lactamase; PDBTitle: crystal structure of putative beta-lactamase (np_815223.1) from2 enterococcus faecalis v583 at 1.50 a resolution 28 c2ov5A_ not modelled 100.0 18 PDB header:hydrolase Chain: A: PDB Molecule:carbapenemase; PDBTitle: crystal structure of the kpc-2 carbapenemase 29 d2cc1a1 not modelled 100.0 19 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 30 d1bsga_ not modelled 100.0 14 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 31 d1buea_ not modelled 100.0 18 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 32 c2wuqA_ not modelled 100.0 19 PDB header:transcription Chain: A: PDB Molecule:beta-lactamase regulatory protein blab; PDBTitle: crystal structure of blab protein from streptomyces cacaoi 33 d1g6aa_ not modelled 100.0 15 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 34 c2qpnA_ not modelled 100.0 15 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase ges-1; PDBTitle: ges-1 beta-lactamase 35 c3lezA_ not modelled 100.0 14 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of a halotolerant bacterial beta-lactamase 36 c3p09A_ not modelled 100.0 14 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of beta-lactamase from francisella tularensis 37 c1w7fB_ not modelled 100.0 16 PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of the class a beta-lactamase bs32 inhibited with isocitrate 38 c2wuqB_ not modelled 100.0 18 PDB header:transcription Chain: B: PDB Molecule:beta-lactamase regulatory protein blab; PDBTitle: crystal structure of blab protein from streptomyces cacaoi 39 d1alqa_ not modelled 100.0 20 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 40 d1djaa_ not modelled 100.0 18 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 41 d1e25a_ not modelled 100.0 17 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 42 c2xftA_ not modelled 100.0 14 PDB header:hydrolase Chain: A: PDB Molecule:orf12; PDBTitle: structural and mechanistic studies on a cephalosporin esterase from2 the clavulanic acid biosynthesis pathway 43 c3a3eB_ not modelled 99.9 23 PDB header:hydrolase Chain: B: PDB Molecule:penicillin-binding protein 4; PDBTitle: crystal structure of penicillin binding protein 4 (dacb)2 from haemophilus influenzae, complexed with novel beta-3 lactam (cmv) 44 d1w5da1 not modelled 99.9 24 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:Dac-like 45 d1w79a1 not modelled 99.9 24 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:Dac-like 46 d2ex2a1 not modelled 99.8 21 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:Dac-like 47 d3beca1 not modelled 99.8 55 Fold:Penicillin-binding protein associated domain Superfamily:Penicillin-binding protein associated domain Family:PBP5 C-terminal domain-like 48 c3i7jB_ not modelled 99.6 18 PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase mb2281c; PDBTitle: crystal structure of a beta-lactamase (mb2281c) from2 mycobacterium bovis, northeast structural genomics3 consortium target mbr246 49 d1nrfa_ not modelled 99.6 15 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 50 d1xa1a_ not modelled 99.6 17 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 51 c2iwdA_ not modelled 99.5 11 PDB header:antibiotic resistance Chain: A: PDB Molecule:methicillin resistance mecr1 protein; PDBTitle: oxacilloyl-acylated mecr1 extracellular antibiotic-sensor2 domain. 52 c2jc7A_ not modelled 99.4 19 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase oxa-24; PDBTitle: the crystal structure of the carbapenemase oxa-24 reveals2 new insights into the mechanism of carbapenem-hydrolysis 53 d1k38a_ not modelled 99.3 14 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 54 c3hbrD_ not modelled 99.3 17 PDB header:hydrolase Chain: D: PDB Molecule:oxa-48; PDBTitle: crystal structure of oxa-48 beta-lactamase 55 c3if6C_ not modelled 99.2 19 PDB header:hydrolase Chain: C: PDB Molecule:oxa-46 oxacillinase; PDBTitle: crystal structure of oxa-46 beta-lactamase from p.2 aeruginosa 56 d1vqqa3 not modelled 99.2 15 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 57 c3pbqA_ not modelled 99.1 23 PDB header:hydrolase/antibiotic Chain: A: PDB Molecule:penicillin-binding protein 3; PDBTitle: crystal structure of pbp3 complexed with imipenem 58 d1k55a_ not modelled 99.1 19 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 59 c3oc2A_ not modelled 99.1 29 PDB header:penicillin-binding protein Chain: A: PDB Molecule:penicillin-binding protein 3; PDBTitle: crystal structure of penicillin-binding protein 3 from pseudomonas2 aeruginosa 60 c3lo7A_ not modelled 99.1 22 PDB header:transferase Chain: A: PDB Molecule:penicillin-binding protein a; PDBTitle: crystal structure of pbpa from mycobacterium tuberculosis 61 d1xp4a1 not modelled 99.1 19 Fold:Penicillin-binding protein associated domain Superfamily:Penicillin-binding protein associated domain Family:PBP5 C-terminal domain-like 62 c2qmiH_ not modelled 99.0 17 PDB header:hydrolase Chain: H: PDB Molecule:pbp related beta-lactamase; PDBTitle: structure of the octameric penicillin-binding protein2 homologue from pyrococcus abyssi 63 d1yqsa1 not modelled 99.0 22 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 64 d1ci9a_ not modelled 99.0 20 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 65 d1pyya4 not modelled 99.0 17 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 66 c2qz6A_ not modelled 99.0 22 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: first crystal structure of a psychrophile class c beta-2 lactamase 67 c1qmfA_ not modelled 99.0 19 PDB header:peptidoglycan synthesis Chain: A: PDB Molecule:penicillin-binding protein 2x; PDBTitle: penicillin-binding protein 2x (pbp-2x) acyl-enzyme complex 68 c2wadB_ not modelled 99.0 18 PDB header:peptide binding protein Chain: B: PDB Molecule:penicillin-binding protein 2b; PDBTitle: penicillin-binding protein 2b (pbp-2b) from streptococcus2 pneumoniae (strain 5204) 69 c3hleA_ not modelled 98.9 21 PDB header:transferase Chain: A: PDB Molecule:transesterase; PDBTitle: simvastatin synthase (lovd), from aspergillus terreus, s5 mutant, s76a2 mutant, complex with monacolin j acid 70 c3fwlA_ not modelled 98.9 18 PDB header:transferase, hydrolase Chain: A: PDB Molecule:penicillin-binding protein 1b; PDBTitle: crystal structure of the full-length transglycosylase pbp1b2 from escherichia coli 71 d2dcfa1 not modelled 98.9 28 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 72 c3equB_ not modelled 98.9 23 PDB header:biosynthetic protein Chain: B: PDB Molecule:penicillin-binding protein 2; PDBTitle: crystal structure of penicillin-binding protein 2 from neisseria2 gonorrhoeae 73 c3ue3A_ not modelled 98.9 25 PDB header:transferase Chain: A: PDB Molecule:septum formation, penicillin binding protein 3, PDBTitle: crystal structure of acinetobacter baumanni pbp3 74 d1rgya_ not modelled 98.9 26 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 75 c3tg9A_ not modelled 98.9 17 PDB header:penicillin binding protein Chain: A: PDB Molecule:penicillin-binding protein; PDBTitle: the crystal structure of penicillin binding protein from bacillus2 halodurans 76 d1rp5a4 not modelled 98.8 16 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 77 c1mwuA_ not modelled 98.8 16 PDB header:biosynthetic protein Chain: A: PDB Molecule:penicillin-binding protein 2a; PDBTitle: structure of methicillin acyl-penicillin binding protein 2a2 from methicillin resistant staphylococcus aureus strain3 27r at 2.60 a resolution. 78 c2wzzA_ not modelled 98.8 21 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: amp-c beta-lactamase (pseudomonas aeruginosa)in complex2 with compound m-03 79 d1m6ka_ not modelled 98.8 14 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 80 d1ei5a3 not modelled 98.8 14 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 81 d1onha_ not modelled 98.8 25 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 82 d2hdsa1 not modelled 98.7 21 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 83 d2drwa1 not modelled 98.7 21 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 84 c1ei5A_ not modelled 98.7 18 PDB header:hydrolase Chain: A: PDB Molecule:d-aminopeptidase; PDBTitle: crystal structure of a d-aminopeptidase from ochrobactrum2 anthropi 85 c1zkjA_ not modelled 98.7 19 PDB header:hydrolase Chain: A: PDB Molecule:extended-spectrum beta-lactamase; PDBTitle: structural basis for the extended substrate spectrum of cmy-2 10, a plasmid-encoded class c beta-lactamase 86 c3o3vB_ not modelled 98.7 21 PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of clbp peptidase domain 87 c3udiA_ not modelled 98.6 15 PDB header:penicillin-binding protein/antibiotic Chain: A: PDB Molecule:penicillin-binding protein 1a; PDBTitle: crystal structure of acinetobacter baumannii pbp1a in complex with2 penicillin g 88 c3ozhA_ not modelled 98.5 22 PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase/d-alanine carboxypeptidase; PDBTitle: crystal structure of beta-lactamase/d-alanine carboxypeptidase from2 yersinia pestis 89 d2c5wb1 not modelled 98.4 17 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 90 c3dwkC_ not modelled 98.1 19 PDB header:transferase Chain: C: PDB Molecule:penicillin-binding protein 2; PDBTitle: identification of dynamic structural motifs involved in2 peptidoglycan glycosyltransfer 91 d2bg1a1 not modelled 98.1 20 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 92 d2olua2 not modelled 98.0 19 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 93 c2olvA_ not modelled 98.0 16 PDB header:transferase Chain: A: PDB Molecule:penicillin-binding protein 2; PDBTitle: structural insight into the transglycosylation step of bacterial cell2 wall biosynthesis : donor ligand complex 94 c1pmdA_ not modelled 98.0 12 PDB header:peptidoglycan synthesis Chain: A: PDB Molecule:peptidoglycan synthesis multifunctional enzyme; PDBTitle: penicillin-binding protein 2x (pbp-2x) 95 c2bg1A_ not modelled 97.9 23 PDB header:peptidoglycan Chain: A: PDB Molecule:penicillin-binding protein 1b; PDBTitle: active site restructuring regulates ligand recognition in2 classa penicillin-binding proteins (pbps) 96 d1k25a4 not modelled 97.7 21 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:beta-Lactamase/D-ala carboxypeptidase 97 c2jciA_ not modelled 97.6 21 PDB header:drug-binding protein Chain: A: PDB Molecule:penicillin-binding protein 1b; PDBTitle: structural insights into the catalytic mechanism and the2 role of streptococcus pneumoniae pbp1b 98 c2pbyB_ not modelled 51.9 21 PDB header:hydrolase Chain: B: PDB Molecule:glutaminase; PDBTitle: probable glutaminase from geobacillus kaustophilus hta426 99 d1u60a_ not modelled 50.8 18 Fold:beta-lactamase/transpeptidase-like Superfamily:beta-lactamase/transpeptidase-like Family:Glutaminase 100 c3czdA_ not modelled 44.5 13 PDB header:hydrolase Chain: A: PDB Molecule:glutaminase kidney isoform; PDBTitle: crystal structure of human glutaminase in complex with l-glutamate 101 c2dfwA_ not modelled 40.2 21 PDB header:hydrolase Chain: A: PDB Molecule:salt-tolerant glutaminase; PDBTitle: crystal structure of a major fragment of the salt-tolerant2 glutaminase from micrococcus luteus k-3 102 c3ih9A_ not modelled 38.2 21 PDB header:hydrolase Chain: A: PDB Molecule:salt-tolerant glutaminase; PDBTitle: crystal structure analysis of mglu in its tris form 103 c3nqyA_ not modelled 34.2 26 PDB header:hydrolase Chain: A: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of the autoprocessed complex of vibriolysin mcp-022 with a single point mutation e346a 104 c3uo9B_ not modelled 33.6 13 PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:glutaminase kidney isoform, mitochondrial; PDBTitle: crystal structure of human gac in complex with glutamate and bptes 105 d2jova1 not modelled 33.4 21 Fold:CPE0013-like Superfamily:CPE0013-like Family:CPE0013-like 106 c3ss4C_ not modelled 33.2 13 PDB header:hydrolase Chain: C: PDB Molecule:glutaminase c; PDBTitle: crystal structure of mouse glutaminase c, phosphate-bound form 107 c3l9vE_ not modelled 23.0 12 PDB header:oxidoreductase Chain: E: PDB Molecule:putative thiol-disulfide isomerase or thioredoxin; PDBTitle: crystal structure of salmonella enterica serovar typhimurium srga

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0