Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	E	R	L	S	W	K	R	L	V	L	E	L	L	L	C	C	L	P	A	F	I	L	G	A	F	F	G	Y	L	P	W	F	L	L	A	S	V	T	G	L	L	I	W	H	F	W	N	L	L	R	L	S	W	W	L	W	V	D
Secondary structure
SS confidence
Disorder		?	?	?	?																																																						?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	S	M	T	P	P	P	G	R	G	S	W	E	P	L	L	Y	G	L	H	Q	M	Q	L	R	N	K	K	R	R	R	E	L	G	N	L	I	K	R	F	R	S	G	A	E	S	L	P	D	A	V	V	L	T	T	E	E	G	G	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	W	C	N	G	L	A	Q	Q	I	L	G	L	R	W	P	E	D	N	G	Q	N	I	L	N	L	L	R	Y	P	E	F	T	Q	Y	L	K	T	R	D	F	S	R	P	L	N	L	V	L	N	T	G	R	H	L	E	I	R	V	M
Secondary structure
SS confidence
Disorder																			?																					?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	Y	T	H	K	Q	L	L	M	V	A	R	D	V	T	Q	M	H	Q	L	E	G	A	R	R	N	F	F	A	N	V	S	H	E	L	R	T	P	L	T	V	L	Q	G	Y	L	E	M	M	N	E	Q	P	L	E	G	A	V	R	E
Secondary structure
SS confidence
Disorder																																																			?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		K	A	L	H	T	M	R	E	Q	T	Q	R	M	E	G	L	V	K	Q	L	L	T	L	S	K	I	E	A	A	P	T	H	L	L	N	E	K	V	D	V	P	M	M	L	R	V	V	E	R	E	A	Q	T	L	S	Q	K	K	Q	T
Secondary structure
SS confidence
Disorder																												?		?	?	?	?																									?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		F	T	F	E	I	D	N	G	L	K	V	S	G	N	E	D	Q	L	R	S	A	I	S	N	L	V	Y	N	A	V	N	H	T	P	E	G	T	H	I	T	V	R	W	Q	R	V	P	H	G	A	E	F	S	V	E	D	N	G	P	G
Secondary structure
SS confidence
Disorder																																																												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		I	A	P	E	H	I	P	R	L	T	E	R	F	Y	R	V	D	K	A	R	S	R	Q	T	G	G	S	G	L	G	L	A	I	V	K	H	A	V	N	H	H	E	S	R	L	N	I	E	S	T	V	G	K	G	T	R	F	S	F	V
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.
Sequence		I	P	E	R	L	I	A	K	N	S	D
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3a0r chain A Region: 100 - 423 Aligned: 309 Modelled: 324 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360) Phyre2 PDB 2q8f chain A Region: 231 - 423 Aligned: 193 Modelled: 193 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1 Phyre2 PDB 3d2r chain B Region: 230 - 423 Aligned: 192 Modelled: 194 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4; PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp Phyre2 PDB 2bu8 chain A Region: 231 - 423 Aligned: 187 Modelled: 193 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2; PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands Phyre2 PDB 3d36 chain B Region: 199 - 423 Aligned: 216 Modelled: 225 Confidence: 100.0% Identity: 25% PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:sporulation kinase b; PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda Phyre2 PDB 1y8o chain A Region: 237 - 423 Aligned: 178 Modelled: 187 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3; PDBTitle: crystal structure of the pdk3-l2 complex Phyre2 PDB 1gjv chain A Region: 213 - 422 Aligned: 202 Modelled: 210 Confidence: 100.0% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s Phyre2 PDB 2c2a chain A Region: 199 - 425 Aligned: 218 Modelled: 227 Confidence: 100.0% Identity: 31% PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein Phyre2 PDB 1jm6 chain A domain 2 Region: 305 - 431 Aligned: 123 Modelled: 123 Confidence: 99.9% Identity: 20% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain Phyre2 PDB 1gkz chain A domain 2 Region: 280 - 423 Aligned: 139 Modelled: 144 Confidence: 99.9% Identity: 16% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain Phyre2 PDB 3a0t chain A Region: 273 - 423 Aligned: 145 Modelled: 151 Confidence: 99.9% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal) Phyre2 PDB 2c2a chain A domain 2 Region: 272 - 425 Aligned: 145 Modelled: 154 Confidence: 99.9% Identity: 30% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 1id0 chain A Region: 275 - 424 Aligned: 144 Modelled: 150 Confidence: 99.9% Identity: 19% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 1b3q chain A Region: 243 - 425 Aligned: 178 Modelled: 183 Confidence: 99.9% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:protein (chemotaxis protein chea); PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase Phyre2 PDB 2ch4 chain A Region: 280 - 425 Aligned: 145 Modelled: 146 Confidence: 99.9% Identity: 23% PDB header:transferase/chemotaxis Chain: A: PDB Molecule:chemotaxis protein chea; PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew Phyre2 PDB 1bxd chain A Region: 272 - 431 Aligned: 154 Modelled: 160 Confidence: 99.9% Identity: 29% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 1i58 chain A Region: 280 - 423 Aligned: 143 Modelled: 143 Confidence: 99.9% Identity: 24% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 1ysr chain A domain 1 Region: 274 - 422 Aligned: 133 Modelled: 131 Confidence: 99.9% Identity: 25% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 3jz3 chain B Region: 237 - 423 Aligned: 154 Modelled: 158 Confidence: 99.8% Identity: 27% PDB header:transferase Chain: B: PDB Molecule:sensor protein qsec; PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec Phyre2 PDB 1r62 chain A Region: 275 - 425 Aligned: 135 Modelled: 140 Confidence: 99.8% Identity: 21% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 3lnr chain A Region: 29 - 107 Aligned: 77 Modelled: 77 Confidence: 81.6% Identity: 16% PDB header:signaling protein Chain: A: PDB Molecule:aerotaxis transducer aer2; PDBTitle: crystal structure of poly-hamp domains from the p. aeruginosa soluble2 receptor aer2 Phyre2 1 c3a0rA_ 2 c2q8fA_ 3 c3d2rB_ 4 c2bu8A_ 5 c3d36B_ 6 c1y8oA_ 7 c1gjvA_ 8 c2c2aA_ 9 d1jm6a2 10 d1gkza2 11 c3a0tA_ 12 d2c2aa2 13 d1id0a_ 14 c1b3qA_ 15 c2ch4A_ 16 d1bxda_ 17 d1i58a_ 18 d1ysra1 19 c3jz3B_ 20 d1r62a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 c3lnrA_ 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3a0rA_ 100.0 21 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360) 2 c2q8fA_ 100.0 19 PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1 3 c3d2rB_ 100.0 20 PDB header:transferase Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4; PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp 4 c2bu8A_ 100.0 18 PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2; PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands 5 c3d36B_ 100.0 25 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:sporulation kinase b; PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda 6 c1y8oA_ 100.0 17 PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3; PDBTitle: crystal structure of the pdk3-l2 complex 7 c1gjvA_ 100.0 15 PDB header:transferase Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s 8 c2c2aA_ 100.0 31 PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein 9 d1jm6a2 99.9 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain 10 d1gkza2 99.9 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain 11 c3a0tA_ 99.9 23 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal) 12 d2c2aa2 99.9 30 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 13 d1id0a_ 99.9 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 14 c1b3qA_ 99.9 20 PDB header:transferase Chain: A: PDB Molecule:protein (chemotaxis protein chea); PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase 15 c2ch4A_ 99.9 23 PDB header:transferase/chemotaxis Chain: A: PDB Molecule:chemotaxis protein chea; PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew 16 d1bxda_ 99.9 29 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 17 d1i58a_ 99.9 24 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 18 d1ysra1 99.9 25 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 19 c3jz3B_ 99.8 27 PDB header:transferase Chain: B: PDB Molecule:sensor protein qsec; PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec 20 d1r62a_ 99.8 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 21 d2hkja3 not modelled 99.8 25 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 22 c1mx0D_ not modelled 99.7 26 PDB header:isomerase Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b; PDBTitle: structure of topoisomerase subunit 23 c2zbkB_ not modelled 99.7 27 PDB header:isomerase Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b; PDBTitle: crystal structure of an intact type ii dna topoisomerase:2 insights into dna transfer mechanisms 24 c3gieA_ not modelled 99.6 28 PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase desk; PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp 25 c3ehgA_ not modelled 99.6 22 PDB header:transferase Chain: A: PDB Molecule:sensor kinase (yocf protein); PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp 26 c3zxqA_ not modelled 99.6 18 PDB header:transferase Chain: A: PDB Molecule:hypoxia sensor histidine kinase response regulator dost; PDBTitle: crystal structure of the atp-binding domain of mycobacterium2 tuberculosis dost 27 c2q2eB_ not modelled 99.5 25 PDB header:isomerase Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b; PDBTitle: crystal structure of the topoisomerase vi holoenzyme from2 methanosarcina mazei 28 d1h7sa2 not modelled 99.4 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 29 c3zxoB_ not modelled 99.4 23 PDB header:transferase Chain: B: PDB Molecule:redox sensor histidine kinase response regulator devs; PDBTitle: crystal structure of the mutant atp-binding domain of2 mycobacterium tuberculosis doss 30 d1bkna2 not modelled 99.4 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 31 d1th8a_ not modelled 99.4 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 32 d1b63a2 not modelled 99.3 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 33 d1y8oa2 not modelled 99.2 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain 34 c3na3A_ not modelled 98.9 31 PDB header:protein binding Chain: A: PDB Molecule:dna mismatch repair protein mlh1; PDBTitle: mutl protein homolog 1 isoform 1 from homo sapiens 35 c2r78D_ not modelled 98.7 17 PDB header:transferase Chain: D: PDB Molecule:sensor protein; PDBTitle: crystal structure of a domain of the sensory box sensor2 histidine kinase/response regulator from geobacter3 sulfurreducens 36 c3mfxA_ not modelled 98.7 19 PDB header:transcription Chain: A: PDB Molecule:sensory box/ggdef family protein; PDBTitle: crystal structure of the sensory box domain of the sensory-2 box/ggdef protein so_1695 from shewanella oneidensis,3 northeast structural genomics consortium target sor288b 37 d1ixma_ not modelled 98.7 10 Fold:Sporulation response regulatory protein Spo0B Superfamily:Sporulation response regulatory protein Spo0B Family:Sporulation response regulatory protein Spo0B 38 d1ew0a_ not modelled 98.6 21 Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Heme-binding PAS domain 39 c3bwlA_ not modelled 98.6 16 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of pas domain of htr-like protein from haloarcula2 marismortui 40 c2jheB_ not modelled 98.6 14 PDB header:transcription Chain: B: PDB Molecule:transcription regulator tyrr; PDBTitle: n-terminal domain of tyrr transcription factor (residues 1 -2 190) 41 c3mxqC_ not modelled 98.6 15 PDB header:transferase Chain: C: PDB Molecule:sensor protein; PDBTitle: crystal structure of sensory box sensor histidine kinase from vibrio2 cholerae 42 c3mqoB_ not modelled 98.4 11 PDB header:transcription regulator Chain: B: PDB Molecule:transcriptional regulator, luxr family; PDBTitle: the crystal structure of the pas domain in complex with isopropanol of2 a transcriptional regulator in the luxr family from burkholderia3 thailandensis to 1.7a 43 c3h4lB_ not modelled 98.4 22 PDB header:dna binding protein, protein binding Chain: B: PDB Molecule:dna mismatch repair protein pms1; PDBTitle: crystal structure of n terminal domain of a dna repair protein 44 c3oloB_ not modelled 98.3 8 PDB header:transferase Chain: B: PDB Molecule:two-component sensor histidine kinase; PDBTitle: crystal structure of a pas domain from two-component sensor histidine2 kinase 45 c1v9yA_ not modelled 98.3 16 PDB header:signaling protein Chain: A: PDB Molecule:heme pas sensor protein; PDBTitle: crystal structure of the heme pas sensor domain of ec dos (ferric2 form) 46 d1v9ya_ not modelled 98.3 16 Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Heme-binding PAS domain 47 c3fg8B_ not modelled 98.3 15 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein rha05790; PDBTitle: crystal structure of pas domain of rha05790 48 c2gj3A_ not modelled 98.3 17 PDB header:transferase Chain: A: PDB Molecule:nitrogen fixation regulatory protein; PDBTitle: crystal structure of the fad-containing pas domain of the2 protein nifl from azotobacter vinelandii. 49 c3b33A_ not modelled 98.3 15 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of the pas domain of nitrogen regulation protein2 nr(ii) from vibrio parahaemolyticus 50 c2w0nA_ not modelled 98.2 19 PDB header:transferase Chain: A: PDB Molecule:sensor protein dcus; PDBTitle: plasticity of pas domain and potential role for signal2 transduction in the histidine-kinase dcus 51 d1nwza_ not modelled 98.2 13 Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:PYP-like 52 c3luqC_ not modelled 98.2 15 PDB header:transferase Chain: C: PDB Molecule:sensor protein; PDBTitle: the crystal structure of a pas domain from a sensory box2 histidine kinase regulator from geobacter sulfurreducens to3 2.5a 53 c2v1bA_ not modelled 98.2 15 PDB header:transferase Chain: A: PDB Molecule:nph1-1; PDBTitle: n- and c-terminal helices of oat lov2 (404-546) are2 involved in light-induced signal transduction (room3 temperature (293k) light structure of lov2 (404-546)) 54 c3caxA_ not modelled 98.2 16 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein pf0695; PDBTitle: crystal structure of uncharacterized protein pf0695 55 c3lyxA_ not modelled 98.1 19 PDB header:transcription Chain: A: PDB Molecule:sensory box/ggdef domain protein; PDBTitle: crystal structure of the pas domain of the protein cps_12912 from colwellia psychrerythraea. northeast structural3 genomics consortium target id csr222b 56 c1bknA_ not modelled 98.1 22 PDB header:dna repair Chain: A: PDB Molecule:mutl; PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl 57 d1kija2 not modelled 98.0 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 58 d1mzua_ not modelled 98.0 11 Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:PYP-like 59 c3k3dA_ not modelled 98.0 15 PDB header:signaling protein Chain: A: PDB Molecule:protein rv1364c/mt1410; PDBTitle: the n-terminal pas domain crystal structure of rv1364c from2 mycobacterium tuberculosis at 2.3 angstrom 60 d1otda_ not modelled 98.0 14 Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:PYP-like 61 c3mjqB_ not modelled 97.9 16 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the pas domain of q24qt8_deshy protein from2 desulfitobacterium hafniense. northeast structural genomics3 consortium target dhr85c. 62 c3kx0X_ not modelled 97.9 15 PDB header:signaling protein Chain: X: PDB Molecule:uncharacterized protein rv1364c/mt1410; PDBTitle: crystal structure of the pas domain of rv1364c 63 c2pr6A_ not modelled 97.9 16 PDB header:flavoprotein, signaling protein Chain: A: PDB Molecule:blue-light photoreceptor; PDBTitle: structural basis for light-dependent signaling in the dimeric lov2 photosensor ytva (light structure) 64 d1s16a2 not modelled 97.9 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 65 c3iedA_ not modelled 97.9 17 PDB header:chaperone Chain: A: PDB Molecule:heat shock protein; PDBTitle: crystal structure of n-terminal domain of plasmodium falciparum hsp902 (pf14_0417) in complex with amppn 66 d1y28a_ not modelled 97.9 17 Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Heme-binding PAS domain 67 c1ea6A_ not modelled 97.9 28 PDB header:dna repair Chain: A: PDB Molecule:pms1 protein homolog 2; PDBTitle: n-terminal 40kda fragment of nhpms2 complexed with adp 68 c1y4sA_ not modelled 97.8 17 PDB header:chaperone Chain: A: PDB Molecule:chaperone protein htpg; PDBTitle: conformation rearrangement of heat shock protein 90 upon2 adp binding 69 c3mr0B_ not modelled 97.8 15 PDB header:transcription regulator Chain: B: PDB Molecule:sensory box histidine kinase/response regulator; PDBTitle: crystal structure of sensory box histidine kinase/response regulator2 from burkholderia thailandensis e264 70 d1xfna1 not modelled 97.8 14 Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:PYP-like 71 c3p7nB_ not modelled 97.8 12 PDB header:dna binding protein Chain: B: PDB Molecule:sensor histidine kinase; PDBTitle: crystal structure of light activated transcription factor el222 from2 erythrobacter litoralis 72 d1ei1a2 not modelled 97.8 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 73 d1pvga2 not modelled 97.8 15 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 74 c3fc7B_ not modelled 97.7 20 PDB header:transferase Chain: B: PDB Molecule:htr-like protein; PDBTitle: the crystal structure of a domain of htr-like protein from haloarcula2 marismortui atcc 43049 75 d1uyla_ not modelled 97.7 11 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 76 d1xj3a1 not modelled 97.7 18 Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Heme-binding PAS domain 77 c2qkpD_ not modelled 97.7 13 PDB header:structural genomics, unknown function Chain: D: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of c-terminal domain of smu_1151c from streptococcus2 mutans 78 c2fwyA_ not modelled 97.6 11 PDB header:chaperone Chain: A: PDB Molecule:heat shock protein hsp 90-alpha; PDBTitle: structure of human hsp90-alpha bound to the potent water2 soluble inhibitor pu-h64 79 c1kijB_ not modelled 97.6 23 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit b; PDBTitle: crystal structure of the 43k atpase domain of thermus thermophilus2 gyrase b in complex with novobiocin 80 c2l4rA_ not modelled 97.6 12 PDB header:transport protein Chain: A: PDB Molecule:potassium voltage-gated channel subfamily h member 2; PDBTitle: nmr solution structure of the n-terminal pas domain of herg 81 c1ei1B_ not modelled 97.6 19 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase b; PDBTitle: dimerization of e. coli dna gyrase b provides a structural mechanism2 for activating the atpase catalytic center 82 c3a0vA_ not modelled 97.6 22 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: pas domain of histidine kinase thka (tm1359) (semet,2 f486m/f489m) 83 c2iopD_ not modelled 97.6 20 PDB header:chaperone Chain: D: PDB Molecule:chaperone protein htpg; PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp 84 d2gqpa1 not modelled 97.5 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 85 c2cg9A_ not modelled 97.5 15 PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex 86 c2vlgD_ not modelled 97.5 16 PDB header:transferase Chain: D: PDB Molecule:sporulation kinase a; PDBTitle: kina pas-a domain, homodimer 87 c2akpA_ not modelled 97.5 16 PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: hsp90 delta24-n210 mutant 88 c2o1wB_ not modelled 97.5 21 PDB header:chaperone Chain: B: PDB Molecule:endoplasmin; PDBTitle: structure of n-terminal plus middle domains (n+m) of grp94 89 c3pehB_ not modelled 97.4 20 PDB header:chaperone Chain: B: PDB Molecule:endoplasmin homolog; PDBTitle: crystal structure of the n-terminal domain of an hsp90 from plasmodium2 falciparum, pfl1070c in the presence of a thienopyrimidine derivative 90 c1s16B_ not modelled 97.4 19 PDB header:isomerase Chain: B: PDB Molecule:topoisomerase iv subunit b; PDBTitle: crystal structure of e. coli topoisomerase iv pare 43kda subunit2 complexed with adpnp 91 c3eehA_ not modelled 97.4 21 PDB header:transferase Chain: A: PDB Molecule:putative light and redox sensing histidine kinase; PDBTitle: the crystal structure of the domain of the putative light and redox2 sensing histidine kinase from haloarcula marismortui 92 c3f1oB_ not modelled 97.4 9 PDB header:transcription Chain: B: PDB Molecule:aryl hydrocarbon receptor nuclear translocator; PDBTitle: crystal structure of the high affinity heterodimer of hif22 alpha and arnt c-terminal pas domains, with an internally-3 bound artificial ligand 93 c2iorA_ not modelled 97.4 26 PDB header:chaperone Chain: A: PDB Molecule:chaperone protein htpg; PDBTitle: crystal structure of the n-terminal domain of htpg, the2 escherichia coli hsp90, bound to adp 94 d2iwxa1 not modelled 97.4 14 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 95 c2wkqA_ not modelled 97.3 14 PDB header:transferase, cell adhesion Chain: A: PDB Molecule:nph1-1, ras-related c3 botulinum toxin substrate PDBTitle: structure of a photoactivatable rac1 containing the lov22 c450a mutant 96 c3ewkA_ not modelled 97.3 12 PDB header:flavoprotein Chain: A: PDB Molecule:sensor protein; PDBTitle: structure of the redox sensor domain of methylococcus capsulatus2 (bath) mmos 97 c1zwhA_ not modelled 97.3 14 PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: yeast hsp82 in complex with the novel hsp90 inhibitor radester amine 98 d1ll8a_ not modelled 97.3 14 Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:N-terminal PAS domain of Pas kinase 99 d1p97a_ not modelled 97.2 12 Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Hypoxia-inducible factor Hif2a, C-terminal domain 100 d1uyma_ not modelled 97.2 12 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 101 c3rtyA_ not modelled 97.2 11 PDB header:circadian clock protein Chain: A: PDB Molecule:period circadian protein; PDBTitle: structure of an enclosed dimer formed by the drosophila period protein 102 d1s14a_ not modelled 97.2 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 103 c1zxnB_ not modelled 97.1 17 PDB header:isomerase Chain: B: PDB Molecule:dna topoisomerase ii, alpha isozyme; PDBTitle: human dna topoisomerase iia atpase/adp 104 c3g7bB_ not modelled 97.1 19 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit b; PDBTitle: staphylococcus aureus gyrase b co-complex with inhibitor 105 d1n9la_ not modelled 97.1 15 Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Flavin-binding PAS domain 106 c3gecA_ not modelled 97.0 6 PDB header:circadian clock protein Chain: A: PDB Molecule:period circadian protein; PDBTitle: crystal structure of a tandem pas domain fragment of2 drosophila period 107 c1wa9A_ not modelled 97.0 10 PDB header:circadian rhythm Chain: A: PDB Molecule:period circadian protein; PDBTitle: crystal structure of the pas repeat region of the2 drosophila clock protein period 108 c2z6dB_ not modelled 96.9 12 PDB header:transferase Chain: B: PDB Molecule:phototropin-2; PDBTitle: crystal structure of lov1 domain of phototropin2 from2 arabidopsis thaliana 109 d1bywa_ not modelled 96.9 13 Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Flavin-binding PAS domain 110 c3lnuA_ not modelled 96.9 17 PDB header:isomerase Chain: A: PDB Molecule:topoisomerase iv subunit b; PDBTitle: crystal structure of pare subunit 111 d1jnua_ not modelled 96.8 11 Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Flavin-binding PAS domain 112 c2kdkA_ not modelled 96.8 11 PDB header:transcription regulator Chain: A: PDB Molecule:aryl hydrocarbon receptor nuclear translocator-like protein PDBTitle: structure of human circadian clock protein bmal2 c-terminal pas domain 113 c2oolA_ not modelled 96.6 9 PDB header:signaling protein Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of the chromophore-binding domain of an unusual2 bacteriophytochrome rpbphp3 from r. palustris 114 d1qy5a_ not modelled 96.5 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 115 c3ke6A_ not modelled 96.4 26 PDB header:unknown function Chain: A: PDB Molecule:protein rv1364c/mt1410; PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis 116 c3icyB_ not modelled 96.4 12 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:sensor protein; PDBTitle: the crystal structure of sensory box histidine2 kinase/response regulator domain from chlorobium tepidum3 tls 117 c1qzrA_ not modelled 96.4 15 PDB header:isomerase Chain: A: PDB Molecule:dna topoisomerase ii; PDBTitle: crystal structure of the atpase region of saccharomyces cerevisiae2 topoisomerase ii bound to icrf-187 (dexrazoxane) 118 c2o1uA_ not modelled 96.3 23 PDB header:chaperone Chain: A: PDB Molecule:endoplasmin; PDBTitle: structure of full length grp94 with amp-pnp bound 119 c2o9bA_ not modelled 95.7 20 PDB header:transferase Chain: A: PDB Molecule:bacteriophytochrome; PDBTitle: crystal structure of bacteriophytochrome chromophore binding domain 120 c3h9wA_ not modelled 94.9 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:diguanylate cyclase with pas/pac sensor; PDBTitle: crystal structure of the n-terminal domain of diguanylate cyclase with2 pas/pac sensor (maqu_2914) from marinobacter aquaeolei, northeast3 structural genomics consortium target mqr66c

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0