Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP37651
DateThu Jan 5 11:56:23 GMT 2012
Unique Job ID8eba1720deea65bb

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c3qxqD_
Top template information
PDB header:hydrolase
Chain: D: PDB Molecule:endoglucanase;
PDBTitle: structure of the bacterial cellulose synthase subunit z in complex2 with cellopentaose
Confidence and coverage
Confidence:100.0% Coverage: 92%
338 residues ( 92% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MNVLRSGIVTMLLLAAFSVQAACTWPAWEQFKKDYISQEGRVIDPSDARKITTSEGQSYG
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Disorder  ?
















?
???
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?

?
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   .........70.........80.........90.........100.........110.........120
Sequence  MFSALAANDRAAFDNILDWTQNNLAQGSLKERLPAWLWGKKENSKWEVLDSNSASDGDVW
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???????







???????????









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   .........130.........140.........150.........160.........170.........180
Sequence  MAWSLLEAGRLWKEQRYTDIGSALLKRIAREEVVTVPGLGSMLLPGKVGFAEDNSWRFNP
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????













































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   .........190.........200.........210.........220.........230.........240
Sequence  SYLPPTLAQYFTRFGAPWTTLRETNQRLLLETAPKGFSPDWVRYEKDKGWQLKAEKTLIS
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???


????


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   .........250.........260.........270.........280.........290.........300
Sequence  SYDAIRVYMWVGMMPDSDPQKARMLNRFKPMATFTEKNGYPPEKVDVATGKAQGKGPVGF
Secondary structure 





















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??































??????




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   .........310.........320.........330.........340.........350.........360
Sequence  SAAMLPFLQNRDAQAVQRQRVADNFPGSDAYYNYVLTLFGQGWDQHRFRFSTKGELLPDW
Secondary structure 






























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Disorder 











?




????????????














?











?
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   ........
Sequence  GQECANSH
Secondary structure 







SS confidence 







Disorder 
???????
Disorder confidence 







 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3qxq chain D

3D model

Region: 23 - 360
Aligned: 338
Modelled: 338
Confidence: 100.0%
Identity: 100%
PDB header:hydrolase
Chain: D: PDB Molecule:endoglucanase;
PDBTitle: structure of the bacterial cellulose synthase subunit z in complex2 with cellopentaose

Phyre2

PDB 1wzz chain A domain 1

3D model

Region: 26 - 344
Aligned: 302
Modelled: 319
Confidence: 100.0%
Identity: 26%
Fold: alpha/alpha toroid
Superfamily: Six-hairpin glycosidases
Family: Cellulases catalytic domain

Phyre2

PDB 1wu4 chain A domain 1

3D model

Region: 37 - 362
Aligned: 306
Modelled: 326
Confidence: 100.0%
Identity: 22%
Fold: alpha/alpha toroid
Superfamily: Six-hairpin glycosidases
Family: Cellulases catalytic domain

Phyre2

PDB 1h12 chain A

3D model

Region: 42 - 350
Aligned: 297
Modelled: 298
Confidence: 100.0%
Identity: 22%
Fold: alpha/alpha toroid
Superfamily: Six-hairpin glycosidases
Family: Cellulases catalytic domain

Phyre2

PDB 1kwf chain A

3D model

Region: 26 - 348
Aligned: 308
Modelled: 319
Confidence: 100.0%
Identity: 22%
Fold: alpha/alpha toroid
Superfamily: Six-hairpin glycosidases
Family: Cellulases catalytic domain

Phyre2

PDB 1v5d chain A

3D model

Region: 26 - 348
Aligned: 312
Modelled: 318
Confidence: 100.0%
Identity: 18%
Fold: alpha/alpha toroid
Superfamily: Six-hairpin glycosidases
Family: Cellulases catalytic domain

Phyre2

PDB 3ren chain B

3D model

Region: 27 - 357
Aligned: 299
Modelled: 323
Confidence: 100.0%
Identity: 14%
PDB header:hydrolase
Chain: B: PDB Molecule:glycosyl hydrolase, family 8;
PDBTitle: cpf_2247, a novel alpha-amylase from clostridium perfringens

Phyre2

PDB 2zzr chain A

3D model

Region: 35 - 198
Aligned: 155
Modelled: 159
Confidence: 94.2%
Identity: 14%
PDB header:hydrolase
Chain: A: PDB Molecule:unsaturated glucuronyl hydrolase;
PDBTitle: crystal structure of unsaturated glucuronyl hydrolase from2 streptcoccus agalactiae

Phyre2

PDB 1fp3 chain A

3D model

Region: 74 - 211
Aligned: 128
Modelled: 133
Confidence: 93.9%
Identity: 12%
Fold: alpha/alpha toroid
Superfamily: Six-hairpin glycosidases
Family: N-acylglucosamine (NAG) epimerase

Phyre2

PDB 2afa chain A domain 1

3D model

Region: 35 - 228
Aligned: 183
Modelled: 185
Confidence: 93.3%
Identity: 8%
Fold: alpha/alpha toroid
Superfamily: Six-hairpin glycosidases
Family: N-acylglucosamine (NAG) epimerase

Phyre2

PDB 3pmm chain A

3D model

Region: 38 - 310
Aligned: 243
Modelled: 238
Confidence: 90.2%
Identity: 11%
PDB header:hydrolase
Chain: A: PDB Molecule:putative cytoplasmic protein;
PDBTitle: the crystal structure of a possible member of gh105 family from2 klebsiella pneumoniae subsp. pneumoniae mgh 78578

Phyre2

PDB 3k11 chain A

3D model

Region: 116 - 305
Aligned: 182
Modelled: 181
Confidence: 88.9%
Identity: 7%
PDB header:hydrolase
Chain: A: PDB Molecule:putative glycosyl hydrolase;
PDBTitle: crystal structure of putative glycosyl hydrolase (np_813087.1) from2 bacteroides thetaiotaomicron vpi-5482 at 1.80 a resolution

Phyre2

PDB 1nxc chain A

3D model

Region: 27 - 321
Aligned: 270
Modelled: 274
Confidence: 83.2%
Identity: 15%
Fold: alpha/alpha toroid
Superfamily: Seven-hairpin glycosidases
Family: Class I alpha-1;2-mannosidase, catalytic domain

Phyre2

PDB 3k7x chain A

3D model

Region: 55 - 243
Aligned: 159
Modelled: 163
Confidence: 74.6%
Identity: 10%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:lin0763 protein;
PDBTitle: crystal structure of the lin0763 protein from listeria2 innocua. northeast structural genomics consortium target3 lkr23.

Phyre2

PDB 3eu8 chain D

3D model

Region: 199 - 292
Aligned: 90
Modelled: 94
Confidence: 69.7%
Identity: 14%
PDB header:hydrolase
Chain: D: PDB Molecule:putative glucoamylase;
PDBTitle: crystal structure of putative glucoamylase (yp_210071.1) from2 bacteroides fragilis nctc 9343 at 2.12 a resolution

Phyre2

PDB 3qsp chain B

3D model

Region: 119 - 291
Aligned: 157
Modelled: 173
Confidence: 68.0%
Identity: 15%
PDB header:hydrolase
Chain: B: PDB Molecule:putative uncharacterized protein;
PDBTitle: analysis of a new family of widely distributed metal-independent alpha2 mannosidases provides unique insight into the processing of n-linked3 glycans, streptococcus pneumoniae sp_2144 non-productive substrate4 complex with alpha-1,6-mannobiose

Phyre2

PDB 1g9g chain A

3D model

Region: 42 - 84
Aligned: 43
Modelled: 43
Confidence: 55.3%
Identity: 30%
Fold: alpha/alpha toroid
Superfamily: Six-hairpin glycosidases
Family: Cellulases catalytic domain

Phyre2

PDB 1x9d chain A

3D model

Region: 27 - 307
Aligned: 256
Modelled: 260
Confidence: 47.2%
Identity: 14%
PDB header:hydrolase
Chain: A: PDB Molecule:endoplasmic reticulum mannosyl-oligosaccharide 1,
PDBTitle: crystal structure of human class i alpha-1,2-mannosidase in2 complex with thio-disaccharide substrate analogue

Phyre2

PDB 1x9d chain A domain 1

3D model

Region: 27 - 307
Aligned: 256
Modelled: 260
Confidence: 47.2%
Identity: 14%
Fold: alpha/alpha toroid
Superfamily: Seven-hairpin glycosidases
Family: Class I alpha-1;2-mannosidase, catalytic domain

Phyre2

PDB 2gz6 chain B

3D model

Region: 70 - 249
Aligned: 178
Modelled: 180
Confidence: 42.9%
Identity: 7%
PDB header:isomerase
Chain: B: PDB Molecule:n-acetyl-d-glucosamine 2-epimerase;
PDBTitle: crystal structure of anabaena sp. ch1 n-acetyl-d-glucosamine 2-2 epimerase at 2.0 a

Phyre2
1

c3qxqD_
2

d1wzza1
3

d1wu4a1
4

d1h12a_
5

d1kwfa_
6

d1v5da_
7

c3renB_
8

c2zzrA_
9

d1fp3a_
10

d2afaa1
11

c3pmmA_
12

c3k11A_
13

d1nxca_
14

c3k7xA_
15

c3eu8D_
16

c3qspB_
17

d1g9ga_
18

c1x9dA_
19

d1x9da1
20

c2gz6B_
21



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63



64






Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3qxqD_



100.0 100 PDB header:hydrolase
Chain: D: PDB Molecule:endoglucanase;
PDBTitle: structure of the bacterial cellulose synthase subunit z in complex2 with cellopentaose
2d1wzza1



100.0 26 Fold:alpha/alpha toroid
Superfamily:Six-hairpin glycosidases
Family:Cellulases catalytic domain
3d1wu4a1



100.0 22 Fold:alpha/alpha toroid
Superfamily:Six-hairpin glycosidases
Family:Cellulases catalytic domain
4d1h12a_



100.0 22 Fold:alpha/alpha toroid
Superfamily:Six-hairpin glycosidases
Family:Cellulases catalytic domain
5d1kwfa_



100.0 22 Fold:alpha/alpha toroid
Superfamily:Six-hairpin glycosidases
Family:Cellulases catalytic domain
6d1v5da_



100.0 18 Fold:alpha/alpha toroid
Superfamily:Six-hairpin glycosidases
Family:Cellulases catalytic domain
7c3renB_



100.0 14 PDB header:hydrolase
Chain: B: PDB Molecule:glycosyl hydrolase, family 8;
PDBTitle: cpf_2247, a novel alpha-amylase from clostridium perfringens
8c2zzrA_



94.2 14 PDB header:hydrolase
Chain: A: PDB Molecule:unsaturated glucuronyl hydrolase;
PDBTitle: crystal structure of unsaturated glucuronyl hydrolase from2 streptcoccus agalactiae
9d1fp3a_



93.9 12 Fold:alpha/alpha toroid
Superfamily:Six-hairpin glycosidases
Family:N-acylglucosamine (NAG) epimerase
10d2afaa1



93.3 8 Fold:alpha/alpha toroid
Superfamily:Six-hairpin glycosidases
Family:N-acylglucosamine (NAG) epimerase
11c3pmmA_



90.2 11 PDB header:hydrolase
Chain: A: PDB Molecule:putative cytoplasmic protein;
PDBTitle: the crystal structure of a possible member of gh105 family from2 klebsiella pneumoniae subsp. pneumoniae mgh 78578
12c3k11A_



88.9 7 PDB header:hydrolase
Chain: A: PDB Molecule:putative glycosyl hydrolase;
PDBTitle: crystal structure of putative glycosyl hydrolase (np_813087.1) from2 bacteroides thetaiotaomicron vpi-5482 at 1.80 a resolution
13d1nxca_



83.2 15 Fold:alpha/alpha toroid
Superfamily:Seven-hairpin glycosidases
Family:Class I alpha-1;2-mannosidase, catalytic domain
14c3k7xA_



74.6 10 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:lin0763 protein;
PDBTitle: crystal structure of the lin0763 protein from listeria2 innocua. northeast structural genomics consortium target3 lkr23.
15c3eu8D_



69.7 14 PDB header:hydrolase
Chain: D: PDB Molecule:putative glucoamylase;
PDBTitle: crystal structure of putative glucoamylase (yp_210071.1) from2 bacteroides fragilis nctc 9343 at 2.12 a resolution
16c3qspB_



68.0 15 PDB header:hydrolase
Chain: B: PDB Molecule:putative uncharacterized protein;
PDBTitle: analysis of a new family of widely distributed metal-independent alpha2 mannosidases provides unique insight into the processing of n-linked3 glycans, streptococcus pneumoniae sp_2144 non-productive substrate4 complex with alpha-1,6-mannobiose
17d1g9ga_



55.3 30 Fold:alpha/alpha toroid
Superfamily:Six-hairpin glycosidases
Family:Cellulases catalytic domain
18c1x9dA_



47.2 14 PDB header:hydrolase
Chain: A: PDB Molecule:endoplasmic reticulum mannosyl-oligosaccharide 1,
PDBTitle: crystal structure of human class i alpha-1,2-mannosidase in2 complex with thio-disaccharide substrate analogue
19d1x9da1



47.2 14 Fold:alpha/alpha toroid
Superfamily:Seven-hairpin glycosidases
Family:Class I alpha-1;2-mannosidase, catalytic domain
20c2gz6B_



42.9 7 PDB header:isomerase
Chain: B: PDB Molecule:n-acetyl-d-glucosamine 2-epimerase;
PDBTitle: crystal structure of anabaena sp. ch1 n-acetyl-d-glucosamine 2-2 epimerase at 2.0 a
21c3e6uA_



not modelled 37.6 14 PDB header:signaling protein
Chain: A: PDB Molecule:lanc-like protein 1;
PDBTitle: crystal structure of human lancl1
22d1hcua_



not modelled 34.1 12 Fold:alpha/alpha toroid
Superfamily:Seven-hairpin glycosidases
Family:Class I alpha-1;2-mannosidase, catalytic domain
23d2p0va1



not modelled 31.2 14 Fold:alpha/alpha toroid
Superfamily:Six-hairpin glycosidases
Family:CPF0428-like
24c2p0vA_



not modelled 31.2 14 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:hypothetical protein bt3781;
PDBTitle: crystal structure of bt3781 protein from bacteroides2 thetaiotaomicron, northeast structural genomics target3 btr58
25c3okfA_



not modelled 21.6 24 PDB header:lyase
Chain: A: PDB Molecule:3-dehydroquinate synthase;
PDBTitle: 2.5 angstrom resolution crystal structure of 3-dehydroquinate synthase2 (arob) from vibrio cholerae
26d2g0da1



not modelled 18.0 14 Fold:alpha/alpha toroid
Superfamily:LanC-like
Family:LanC-like
27c3rbbA_



not modelled 17.4 30 PDB header:viral protein, protein binding
Chain: A: PDB Molecule:protein nef;
PDBTitle: hiv-1 nef protein in complex with engineered hck sh3 domain
28d2nvpa1



not modelled 16.9 14 Fold:alpha/alpha toroid
Superfamily:Six-hairpin glycosidases
Family:CPF0428-like
29d1l1ya_



not modelled 15.8 16 Fold:alpha/alpha toroid
Superfamily:Six-hairpin glycosidases
Family:Cellulases catalytic domain
30c1l2aD_



not modelled 15.8 16 PDB header:hydrolase
Chain: D: PDB Molecule:cellobiohydrolase;
PDBTitle: the crystal structure and catalytic mechanism of2 cellobiohydrolase cels, the major enzymatic component of3 the clostridium thermocellum cellulosome
31d2nefa_



not modelled 15.8 29 Fold:Regulatory factor Nef
Superfamily:Regulatory factor Nef
Family:Regulatory factor Nef
32c3jtgA_



not modelled 15.7 23 PDB header:transcription
Chain: A: PDB Molecule:ets-related transcription factor elf-3;
PDBTitle: crystal structure of mouse elf3 c-terminal dna-binding domain in2 complex with type ii tgf-beta receptor promoter dna
33c3gt5A_



not modelled 15.1 10 PDB header:isomerase
Chain: A: PDB Molecule:n-acetylglucosamine 2-epimerase;
PDBTitle: crystal structure of an n-acetylglucosamine 2-epimerase family protein2 from xylella fastidiosa
34d1nc5a_



not modelled 13.7 14 Fold:alpha/alpha toroid
Superfamily:Six-hairpin glycosidases
Family:Hypothetical protein YteR
35c1p0oA_



not modelled 13.0 30 PDB header:ribosome
Chain: A: PDB Molecule:19-mer peptide from 50s ribosomal protein l1;
PDBTitle: hp (2-20) substitution of trp for gln and asp at position2 17 and 19 modification in sds-d25 micelles
36c3l55B_



not modelled 12.7 15 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:b-1,4-endoglucanase/cellulase;
PDBTitle: crystal structure of a putative beta-1,4-endoglucanase /2 cellulase from prevotella bryantii
37c3ik5A_



not modelled 12.6 25 PDB header:viral protein/signaling protein
Chain: A: PDB Molecule:protein nef;
PDBTitle: sivmac239 nef in complex with tcr zeta itam 1 polypeptide2 (a63-r80)
38c2d3wB_



not modelled 12.1 29 PDB header:biosynthetic protein
Chain: B: PDB Molecule:probable atp-dependent transporter sufc;
PDBTitle: crystal structure of escherichia coli sufc, an atpase2 compenent of the suf iron-sulfur cluster assembly machinery
39c2dcoA_



not modelled 10.8 63 PDB header:membrane protein
Chain: A: PDB Molecule:s1p4 first extracellular loop peptidomimetic;
PDBTitle: s1p4 first extracellular loop peptidomimetic
40c2xi1A_



not modelled 10.0 30 PDB header:viral protein
Chain: A: PDB Molecule:nef;
PDBTitle: crystal structure of the hiv-1 nef sequenced from a patient's sample
41d1jb7a1



not modelled 9.8 17 Fold:OB-fold
Superfamily:Nucleic acid-binding proteins
Family:Single strand DNA-binding domain, SSB
42c3nfvA_



not modelled 9.0 13 PDB header:lyase
Chain: A: PDB Molecule:alginate lyase;
PDBTitle: crystal structure of an alginate lyase (bacova_01668) from bacteroides2 ovatus at 1.95 a resolution
43d1efnb_



not modelled 8.9 30 Fold:Regulatory factor Nef
Superfamily:Regulatory factor Nef
Family:Regulatory factor Nef
44d1puee_



not modelled 8.4 18 Fold:DNA/RNA-binding 3-helical bundle
Superfamily:"Winged helix" DNA-binding domain
Family:ets domain
45d1lm7a_



not modelled 8.3 20 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Plakin repeat
Family:Plakin repeat
46c2oylB_



not modelled 7.9 15 PDB header:hydrolase
Chain: B: PDB Molecule:endoglycoceramidase ii;
PDBTitle: endo-glycoceramidase ii from rhodococcus sp.: cellobiose-like2 imidazole complex
47d1rmva_



not modelled 6.8 24 Fold:Four-helical up-and-down bundle
Superfamily:TMV-like viral coat proteins
Family:TMV-like viral coat proteins
48d1g99a2



not modelled 6.6 31 Fold:Ribonuclease H-like motif
Superfamily:Actin-like ATPase domain
Family:Acetokinase-like
49d1pgl21



not modelled 6.6 19 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins)
Superfamily:Positive stranded ssRNA viruses
Family:Comoviridae-like VP
50d1pgw21



not modelled 6.5 19 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins)
Superfamily:Positive stranded ssRNA viruses
Family:Comoviridae-like VP
51d1ny721



not modelled 6.4 13 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins)
Superfamily:Positive stranded ssRNA viruses
Family:Comoviridae-like VP
52d1xjva1



not modelled 6.3 12 Fold:OB-fold
Superfamily:Nucleic acid-binding proteins
Family:Single strand DNA-binding domain, SSB
53d1ei7a_



not modelled 6.2 21 Fold:Four-helical up-and-down bundle
Superfamily:TMV-like viral coat proteins
Family:TMV-like viral coat proteins
54c1lf6A_



not modelled 6.1 20 PDB header:hydrolase
Chain: A: PDB Molecule:glucoamylase;
PDBTitle: crystal structure of bacterial glucoamylase
55c3pdmP_



not modelled 6.1 24 PDB header:virus
Chain: P: PDB Molecule:coat protein;
PDBTitle: hibiscus latent singapore virus
56d2d5ja1



not modelled 5.9 10 Fold:alpha/alpha toroid
Superfamily:Six-hairpin glycosidases
Family:Glycosyl Hydrolase Family 88
57d1vtmp_



not modelled 5.9 17 Fold:Four-helical up-and-down bundle
Superfamily:TMV-like viral coat proteins
Family:TMV-like viral coat proteins
58c3sm3A_



not modelled 5.9 12 PDB header:transferase
Chain: A: PDB Molecule:sam-dependent methyltransferases;
PDBTitle: crystal structure of sam-dependent methyltransferases q8puk2_metma2 from methanosarcina mazei. northeast structural genomics consortium3 target mar262.
59c3mtiA_



not modelled 5.7 19 PDB header:transferase
Chain: A: PDB Molecule:rrna methylase;
PDBTitle: the crystal structure of a rrna methylase from streptococcus2 thermophilus to 1.95a
60c2bfuL_



not modelled 5.6 10 PDB header:virus
Chain: L: PDB Molecule:cowpea mosaic virus, large (l) subunit;
PDBTitle: x-ray structure of cpmv top component
61c1bmv2_



not modelled 5.4 14 PDB header:virus/rna
Chain: 2: PDB Molecule:protein (icosahedral virus - b and c domain);
PDBTitle: protein-rna interactions in an icosahedral virus at 3.02 angstroms resolution
62c1ta9A_



not modelled 5.2 18 PDB header:oxidoreductase
Chain: A: PDB Molecule:glycerol dehydrogenase;
PDBTitle: crystal structure of glycerol dehydrogenase from schizosaccharomyces2 pombe
63c2ov2O_



not modelled 5.1 29 PDB header:protein binding/transferase
Chain: O: PDB Molecule:serine/threonine-protein kinase pak 4;
PDBTitle: the crystal structure of the human rac3 in complex with the crib2 domain of human p21-activated kinase 4 (pak4)
64c2yfvC_



not modelled 5.0 35 PDB header:cell cycle
Chain: C: PDB Molecule:scm3;
PDBTitle: the heterotrimeric complex of kluyveromyces lactis scm3, cse4 and h4

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0