Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP27298
DateWed Jan 25 15:20:46 GMT 2012
Unique Job ID7fdef948df9a1764

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c1y791_
Top template information
PDB header:hydrolase
Chain: 1: PDB Molecule:peptidyl-dipeptidase dcp;
PDBTitle: crystal structure of the e.coli dipeptidyl carboxypeptidase2 dcp in complex with a peptidic inhibitor
Confidence and coverage
Confidence:100.0% Coverage: 99%
670 residues ( 99% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MTNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVD
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Disorder  ???????




















































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   .........70.........80.........90.........100.........110.........120
Sequence  DVLGRIFSPVSHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYA
Secondary structure 








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???
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   .........130.........140.........150.........160.........170.........180
Sequence  TLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKL
Secondary structure 








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Disorder  ?



















???



































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   .........190.........200.........210.........220.........230.........240
Sequence  VTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
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?????????































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   .........250.........260.........270.........280.........290.........300
Sequence  TRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTD
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Disorder 



???




































??













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   .........310.........320.........330.........340.........350.........360
Sequence  LAKRARPQGEKELAQLRAFAKAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPEN
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?????















??????










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   .........370.........380.........390.........400.........410.........420
Sequence  KAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENNELRGSFYLDLYARENKRGG
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?




















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   .........430.........440.........450.........460.........470.........480
Sequence  AWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
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????????













?????

























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   .........490.........500.........510.........520.........530.........540
Sequence  RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAK
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??????












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   .........550.........560.........570.........580.........590.........600
Sequence  NYQAALFILRQLEFGLFDFRLHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFS
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   .........610.........620.........630.........640.........650.........660
Sequence  HIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQSFLDNILSRGGSEEPMDLFK
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??

























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   .........670.........680
Sequence  RFRGREPQLDAMLEHYGIKG
Secondary structure 










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Disorder 














?????
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1y79 chain 1

3D model

Region: 2 - 679
Aligned: 670
Modelled: 674
Confidence: 100.0%
Identity: 32%
PDB header:hydrolase
Chain: 1: PDB Molecule:peptidyl-dipeptidase dcp;
PDBTitle: crystal structure of the e.coli dipeptidyl carboxypeptidase2 dcp in complex with a peptidic inhibitor

Phyre2

PDB 1s4b chain P

3D model

Region: 15 - 678
Aligned: 643
Modelled: 664
Confidence: 100.0%
Identity: 31%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Neurolysin-like

Phyre2

PDB 1i1i chain P

3D model

Region: 4 - 678
Aligned: 654
Modelled: 675
Confidence: 100.0%
Identity: 30%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Neurolysin-like

Phyre2

PDB 3ce2 chain A

3D model

Region: 5 - 675
Aligned: 561
Modelled: 605
Confidence: 100.0%
Identity: 16%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:putative peptidase;
PDBTitle: crystal structure of putative peptidase from chlamydophila abortus

Phyre2

PDB 2h1j chain A

3D model

Region: 11 - 676
Aligned: 539
Modelled: 542
Confidence: 100.0%
Identity: 18%
PDB header:hydrolase
Chain: A: PDB Molecule:oligoendopeptidase f;
PDBTitle: 3.1 a x-ray structure of putative oligoendopeptidase f: crystals grown2 by microfluidic seeding

Phyre2

PDB 3sks chain A

3D model

Region: 2 - 677
Aligned: 525
Modelled: 557
Confidence: 100.0%
Identity: 19%
PDB header:hydrolase
Chain: A: PDB Molecule:putative oligoendopeptidase f;
PDBTitle: crystal structure of a putative oligoendopeptidase f from bacillus2 anthracis str. ames

Phyre2

PDB 2ajf chain A domain 1

3D model

Region: 49 - 676
Aligned: 528
Modelled: 556
Confidence: 100.0%
Identity: 14%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Neurolysin-like

Phyre2

PDB 1uze chain A

3D model

Region: 45 - 676
Aligned: 534
Modelled: 584
Confidence: 100.0%
Identity: 13%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Neurolysin-like

Phyre2

PDB 2c6n chain A

3D model

Region: 43 - 676
Aligned: 531
Modelled: 562
Confidence: 100.0%
Identity: 16%
PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:angiotensin-converting enzyme, somatic isoform;
PDBTitle: structure of human somatic angiontensin-i converting enzyme n domain2 with lisinopril

Phyre2

PDB 1j36 chain A

3D model

Region: 48 - 676
Aligned: 524
Modelled: 576
Confidence: 100.0%
Identity: 17%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Neurolysin-like

Phyre2

PDB 2qr4 chain B

3D model

Region: 23 - 675
Aligned: 476
Modelled: 513
Confidence: 100.0%
Identity: 17%
PDB header:hydrolase
Chain: B: PDB Molecule:peptidase m3b, oligoendopeptidase f;
PDBTitle: crystal structure of oligoendopeptidase-f from enterococcus faecium

Phyre2

PDB 1k9x chain A

3D model

Region: 45 - 676
Aligned: 464
Modelled: 487
Confidence: 100.0%
Identity: 15%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Neurolysin-like

Phyre2

PDB 1wgz chain C

3D model

Region: 47 - 676
Aligned: 463
Modelled: 487
Confidence: 100.0%
Identity: 18%
PDB header:hydrolase
Chain: C: PDB Molecule:carboxypeptidase 1;
PDBTitle: crystal structure of carboxypeptidase 1 from thermus thermophilus

Phyre2

PDB 3dwc chain A

3D model

Region: 54 - 676
Aligned: 449
Modelled: 475
Confidence: 100.0%
Identity: 15%
PDB header:hydrolase
Chain: A: PDB Molecule:metallocarboxypeptidase;
PDBTitle: trypanosoma cruzi metallocarboxypeptidase 1

Phyre2

PDB 3hq2 chain A

3D model

Region: 48 - 676
Aligned: 463
Modelled: 475
Confidence: 100.0%
Identity: 14%
PDB header:hydrolase
Chain: A: PDB Molecule:bacillus subtilis m32 carboxypeptidase;
PDBTitle: bsucp crystal structure

Phyre2

PDB 1g9k chain A domain 2

3D model

Region: 347 - 475
Aligned: 95
Modelled: 110
Confidence: 96.0%
Identity: 23%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Serralysin-like metalloprotease, catalytic (N-terminal) domain

Phyre2

PDB 1kap chain P domain 2

3D model

Region: 361 - 475
Aligned: 89
Modelled: 95
Confidence: 95.9%
Identity: 21%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Serralysin-like metalloprotease, catalytic (N-terminal) domain

Phyre2

PDB 1k7i chain A domain 2

3D model

Region: 347 - 475
Aligned: 99
Modelled: 107
Confidence: 95.6%
Identity: 19%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Serralysin-like metalloprotease, catalytic (N-terminal) domain

Phyre2

PDB 1qib chain A

3D model

Region: 359 - 475
Aligned: 96
Modelled: 99
Confidence: 95.5%
Identity: 13%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Matrix metalloproteases, catalytic domain

Phyre2

PDB 1y93 chain A domain 1

3D model

Region: 359 - 475
Aligned: 95
Modelled: 99
Confidence: 95.4%
Identity: 14%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Matrix metalloproteases, catalytic domain

Phyre2
1

c1y791_
2

d1s4bp_
3

d1i1ip_
4

c3ce2A_
5

c2h1jA_
6

c3sksA_
7

d2ajfa1
8

d1uzea_
9

c2c6nA_
10

d1j36a_
11

c2qr4B_
12

d1k9xa_
13

c1wgzC_
14

c3dwcA_
15

c3hq2A_
16

d1g9ka2
17

d1kapp2
18

d1k7ia2
19

d1qiba_
20

d1y93a1
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c1y791_



100.0 32 PDB header:hydrolase
Chain: 1: PDB Molecule:peptidyl-dipeptidase dcp;
PDBTitle: crystal structure of the e.coli dipeptidyl carboxypeptidase2 dcp in complex with a peptidic inhibitor
2d1s4bp_



100.0 31 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Neurolysin-like
3d1i1ip_



100.0 30 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Neurolysin-like
4c3ce2A_



100.0 16 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:putative peptidase;
PDBTitle: crystal structure of putative peptidase from chlamydophila abortus
5c2h1jA_



100.0 18 PDB header:hydrolase
Chain: A: PDB Molecule:oligoendopeptidase f;
PDBTitle: 3.1 a x-ray structure of putative oligoendopeptidase f: crystals grown2 by microfluidic seeding
6c3sksA_



100.0 19 PDB header:hydrolase
Chain: A: PDB Molecule:putative oligoendopeptidase f;
PDBTitle: crystal structure of a putative oligoendopeptidase f from bacillus2 anthracis str. ames
7d2ajfa1



100.0 14 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Neurolysin-like
8d1uzea_



100.0 13 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Neurolysin-like
9c2c6nA_



100.0 16 PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:angiotensin-converting enzyme, somatic isoform;
PDBTitle: structure of human somatic angiontensin-i converting enzyme n domain2 with lisinopril
10d1j36a_



100.0 17 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Neurolysin-like
11c2qr4B_



100.0 17 PDB header:hydrolase
Chain: B: PDB Molecule:peptidase m3b, oligoendopeptidase f;
PDBTitle: crystal structure of oligoendopeptidase-f from enterococcus faecium
12d1k9xa_



100.0 15 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Neurolysin-like
13c1wgzC_



100.0 18 PDB header:hydrolase
Chain: C: PDB Molecule:carboxypeptidase 1;
PDBTitle: crystal structure of carboxypeptidase 1 from thermus thermophilus
14c3dwcA_



100.0 15 PDB header:hydrolase
Chain: A: PDB Molecule:metallocarboxypeptidase;
PDBTitle: trypanosoma cruzi metallocarboxypeptidase 1
15c3hq2A_



100.0 14 PDB header:hydrolase
Chain: A: PDB Molecule:bacillus subtilis m32 carboxypeptidase;
PDBTitle: bsucp crystal structure
16d1g9ka2



96.0 23 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain
17d1kapp2



95.9 21 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain
18d1k7ia2



95.6 19 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain
19d1qiba_



95.5 13 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
20d1y93a1



95.4 14 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
21d1hfca_



not modelled 95.4 15 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
22d2ovxa1



not modelled 95.3 14 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
23d1cgla_



not modelled 95.3 16 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
24d1hv5a_



not modelled 95.0 15 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
25d1j7na2



not modelled 94.8 14 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Anthrax toxin lethal factor, N- and C-terminal domains
26c1om8A_



not modelled 94.7 25 PDB header:hydrolase
Chain: A: PDB Molecule:serralysin;
PDBTitle: crystal structure of a cold adapted alkaline protease from pseudomonas2 tac ii 18, co-crystallyzed with 10 mm edta
27d1xuca1



not modelled 94.1 15 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
28c2xs4A_



not modelled 94.1 12 PDB header:hydrolase
Chain: A: PDB Molecule:karilysin protease;
PDBTitle: structure of karilysin catalytic mmp domain in complex with2 magnesium
29d1mmqa_



not modelled 94.0 10 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
30d1sata2



not modelled 93.9 16 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain
31c2cltB_



not modelled 93.8 14 PDB header:hydrolase
Chain: B: PDB Molecule:interstitial collagenase;
PDBTitle: crystal structure of the active form (full-length) of human2 fibroblast collagenase.
32c2jsdA_



not modelled 93.7 12 PDB header:hydrolase
Chain: A: PDB Molecule:matrix metalloproteinase-20;
PDBTitle: solution structure of mmp20 complexed with nngh
33c2l0rA_



not modelled 93.6 14 PDB header:hydrolase,toxin
Chain: A: PDB Molecule:lethal factor;
PDBTitle: conformational dynamics of the anthrax lethal factor catalytic center
34d1hova_



not modelled 93.5 13 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
35c1jiwP_



not modelled 93.5 20 PDB header:hydrolase/hyrolase inhibitor
Chain: P: PDB Molecule:alkaline metalloproteinase;
PDBTitle: crystal structure of the apr-aprin complex
36c3g5cA_



not modelled 93.4 14 PDB header:membrane protein
Chain: A: PDB Molecule:adam 22;
PDBTitle: structural and biochemical studies on the ectodomain of human adam22
37d1q3aa_



not modelled 93.3 9 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
38c3edhA_



not modelled 93.1 24 PDB header:hydrolase
Chain: A: PDB Molecule:bone morphogenetic protein 1;
PDBTitle: crystal structure of bone morphogenetic protein 1 protease2 domain in complex with partially bound dmso
39c2xhqA_



not modelled 93.0 20 PDB header:hydrolase
Chain: A: PDB Molecule:archaemetzincin;
PDBTitle: crystal structure of archaemetzincin (amza) from archaeoglobus2 fulgidus at 1.45 a resolution
40c1slmA_



not modelled 93.0 17 PDB header:hydrolase
Chain: A: PDB Molecule:stromelysin-1;
PDBTitle: crystal structure of fibroblast stromelysin-1: the c-truncated human2 proenzyme
41c3p24C_



not modelled 92.9 26 PDB header:hydrolase
Chain: C: PDB Molecule:bft-3;
PDBTitle: structure of profragilysin-3 from bacteroides fragilis
42d1bqqm_



not modelled 92.8 13 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
43d1eaka2



not modelled 92.5 13 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
44d1fbla2



not modelled 92.4 12 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
45d1i76a_



not modelled 92.3 12 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
46c3dtkA_



not modelled 92.2 16 PDB header:gene regulation
Chain: A: PDB Molecule:irre protein;
PDBTitle: crystal structure of the irre protein, a central regulator2 of dna damage repair in deinococcaceae
47d1rm8a_



not modelled 92.0 12 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
48c3k7lA_



not modelled 91.9 28 PDB header:hydrolase
Chain: A: PDB Molecule:atragin;
PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins
49d1cxva_



not modelled 91.6 15 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
50c1yqyA_



not modelled 91.5 27 PDB header:hydrolase
Chain: A: PDB Molecule:lethal factor;
PDBTitle: structure of b. anthrax lethal factor in complex with a2 hydroxamate inhibitor
51c1su3A_



not modelled 91.4 15 PDB header:hydrolase
Chain: A: PDB Molecule:interstitial collagenase;
PDBTitle: x-ray structure of human prommp-1: new insights into2 collagenase action
52d1hy7a_



not modelled 91.4 14 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
53c3ba0A_



not modelled 91.3 18 PDB header:hydrolase
Chain: A: PDB Molecule:macrophage metalloelastase;
PDBTitle: crystal structure of full-length human mmp-12
54d1asta_



not modelled 91.1 23 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Astacin
55c3o0yC_



not modelled 90.9 13 PDB header:lipid binding protein
Chain: C: PDB Molecule:lipoprotein;
PDBTitle: the crystal structure of the putative lipoprotein from colwellia2 psychrerythraea
56c3lqbA_



not modelled 90.9 24 PDB header:hydrolase
Chain: A: PDB Molecule:loc792177 protein;
PDBTitle: crystal structure of the hatching enzyme zhe1 from the zebrafish danio2 rerio
57c3lq0A_



not modelled 89.4 21 PDB header:hydrolase
Chain: A: PDB Molecule:proastacin;
PDBTitle: zymogen structure of crayfish astacin metallopeptidase
58c1pwqA_



not modelled 89.2 29 PDB header:hydrolase
Chain: A: PDB Molecule:lethal factor;
PDBTitle: crystal structure of anthrax lethal factor complexed with2 thioacetyl-tyr-pro-met-amide, a metal-chelating peptidyl3 small molecule inhibitor
59c2erpA_



not modelled 88.9 19 PDB header:toxin
Chain: A: PDB Molecule:vascular apoptosis-inducing protein 1;
PDBTitle: crystal structure of vascular apoptosis-inducing protein-1(inhibitor-2 bound form)
60d1quaa_



not modelled 88.6 21 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
61d1atla_



not modelled 88.5 19 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
62d4aiga_



not modelled 88.1 21 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
63c1yp1A_



not modelled 87.5 16 PDB header:hydrolase
Chain: A: PDB Molecule:fii;
PDBTitle: crystal structure of a non-hemorrhagic fibrin(ogen)olytic2 metalloproteinase from venom of agkistrodon acutus
64d1kufa_



not modelled 86.8 26 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
65d1nd1a_



not modelled 86.6 24 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
66d2i47a1



not modelled 86.6 27 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:TNF-alpha converting enzyme, TACE, catalytic domain
67c3nqzB_



not modelled 86.5 16 PDB header:hydrolase
Chain: B: PDB Molecule:secreted metalloprotease mcp02;
PDBTitle: crystal structure of the autoprocessed vibriolysin mcp-02 with e369a2 mutation
68c2i47A_



not modelled 86.4 27 PDB header:hydrolase
Chain: A: PDB Molecule:adam 17;
PDBTitle: crystal structure of catalytic domain of tace with inhibitor
69d1r55a_



not modelled 85.7 20 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
70c1satA_



not modelled 85.5 16 PDB header:hydrolase (serine protease)
Chain: A: PDB Molecule:serratia protease;
PDBTitle: crystal structure of the 50 kda metallo protease from s.2 marcescens
71c2fpqA_



not modelled 85.5 47 PDB header:toxin
Chain: A: PDB Molecule:botulinum neurotoxin d light chain;
PDBTitle: crystal structure of botulinum neurotoxin type d light chain
72d1wnia_



not modelled 85.4 24 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
73d1bswa_



not modelled 85.2 23 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
74c1zb7A_



not modelled 84.5 41 PDB header:toxin
Chain: A: PDB Molecule:neurotoxin;
PDBTitle: crystal structure of botulinum neurotoxin type g light chain
75d1epwa3



not modelled 84.2 35 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Clostridium neurotoxins, catalytic domain
76c1z7hA_



not modelled 84.1 35 PDB header:hydrolase
Chain: A: PDB Molecule:tetanus toxin light chain;
PDBTitle: 2.3 angstrom crystal structure of tetanus neurotoxin light2 chain
77d1f83a_



not modelled 84.1 35 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Clostridium neurotoxins, catalytic domain
78c3k3qB_



not modelled 84.0 35 PDB header:immune system
Chain: B: PDB Molecule:botulinum neurotoxin type a;
PDBTitle: crystal structure of a llama antibody complexed with the c.2 botulinum neurotoxin serotype a catalytic domain
79c2qn0A_



not modelled 84.0 29 PDB header:toxin
Chain: A: PDB Molecule:neurotoxin;
PDBTitle: structure of botulinum neurotoxin serotype c1 light chain2 protease
80d3bona1



not modelled 83.9 35 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Clostridium neurotoxins, catalytic domain
81c2vqxA_



not modelled 83.9 9 PDB header:hydrolase
Chain: A: PDB Molecule:metalloproteinase;
PDBTitle: precursor of protealysin, metalloproteinase from serratia2 proteamaculans.
82d1kjpa_



not modelled 83.9 13 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Thermolysin-like
83c2dw1B_



not modelled 83.8 33 PDB header:apoptosis, toxin
Chain: B: PDB Molecule:catrocollastatin;
PDBTitle: crystal structure of vap2 from crotalus atrox venom (form 2-2 crystal)
84c1e1hC_



not modelled 83.7 35 PDB header:hydrolase
Chain: C: PDB Molecule:botulinum neurotoxin type a light chain;
PDBTitle: crystal structure of recombinant botulinum neurotoxin type2 a light chain, self-inhibiting zn endopeptidase.
85d1u4ga_



not modelled 83.5 18 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Thermolysin-like
86d1npca_



not modelled 83.5 20 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Thermolysin-like
87c3k7nA_



not modelled 83.5 29 PDB header:hydrolase
Chain: A: PDB Molecule:k-like;
PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins
88c3nqxA_



not modelled 83.4 16 PDB header:hydrolase
Chain: A: PDB Molecule:secreted metalloprotease mcp02;
PDBTitle: crystal structure of vibriolysin mcp-02 mature enzyme, a zinc2 metalloprotease from m4 family
89d3btaa3



not modelled 83.4 35 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Clostridium neurotoxins, catalytic domain
90d1t3ca_



not modelled 83.3 35 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Clostridium neurotoxins, catalytic domain
91c2ilpA_



not modelled 83.3 35 PDB header:hydrolase
Chain: A: PDB Molecule:botulinum neurotoxin a light-chain;
PDBTitle: clostridium botulinum serotype a light chain inhibited by 4-2 chlorocinnamic hydroxamate
92c2a97B_



not modelled 83.1 41 PDB header:hydrolase
Chain: B: PDB Molecule:botulinum neurotoxin type f;
PDBTitle: crystal structure of catalytic domain of clostridium2 botulinum neurotoxin serotype f
93c3b8zB_



not modelled 83.0 46 PDB header:hydrolase
Chain: B: PDB Molecule:protein adamts-5;
PDBTitle: high resolution crystal structure of the catalytic domain2 of adamts-5 (aggrecanase-2)
94c2xhlA_



not modelled 82.5 35 PDB header:hydrolase
Chain: A: PDB Molecule:botulinum neurotoxin b light chain;
PDBTitle: structure of a functional derivative of clostridium2 botulinum neurotoxin type b
95c2x7mA_



not modelled 81.8 20 PDB header:hydrolase
Chain: A: PDB Molecule:archaemetzincin;
PDBTitle: crystal structure of archaemetzincin (amza) from methanopyrus2 kandleri at 1.5 a resolution
96c3zuqA_



not modelled 80.8 35 PDB header:hydrolase
Chain: A: PDB Molecule:botulinum neurotoxin type b;
PDBTitle: crystal structure of an engineered botulinum neurotoxin2 type b-derivative, lc-b-gs-hn-b
97c3zusD_



not modelled 80.7 35 PDB header:hydrolase/signaling protein
Chain: D: PDB Molecule:botulinum neurotoxin type a, synaptosomal-associated
PDBTitle: crystal structure of an engineered botulinum neurotoxin2 type a-snare23 derivative, lc-a-snap23-hn-a
98c2e3xA_



not modelled 80.7 23 PDB header:hydrolase, blood clotting, toxin
Chain: A: PDB Molecule:coagulation factor x-activating enzyme heavy chain;
PDBTitle: crystal structure of russell's viper venom metalloproteinase
99c2rjqA_



not modelled 80.6 38 PDB header:hydrolase
Chain: A: PDB Molecule:adamts-5;
PDBTitle: crystal structure of adamts5 with inhibitor bound
100c3ffzA_



not modelled 80.4 41 PDB header:hydrolase
Chain: A: PDB Molecule:botulinum neurotoxin type e;
PDBTitle: domain organization in clostridium butulinum neurotoxin2 type e is unique: its implication in faster translocation
101c2j83B_



not modelled 80.0 30 PDB header:hydrolase
Chain: B: PDB Molecule:ulilysin;
PDBTitle: ulilysin metalloprotease in complex with batimastat.
102d1bqba_



not modelled 79.7 24 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Thermolysin-like
103c2rjpC_



not modelled 79.1 25 PDB header:hydrolase
Chain: C: PDB Molecule:adamts-4;
PDBTitle: crystal structure of adamts4 with inhibitor bound
104c3b4rB_



not modelled 79.1 42 PDB header:hydrolase
Chain: B: PDB Molecule:putative zinc metalloprotease mj0392;
PDBTitle: site-2 protease from methanocaldococcus jannaschii
105d2ejqa1



not modelled 78.9 33 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:TTHA0227-like
106c2nyyA_



not modelled 78.3 35 PDB header:toxin/immune system
Chain: A: PDB Molecule:botulinum neurotoxin type a;
PDBTitle: crystal structure of botulinum neurotoxin type a complexed with2 monoclonal antibody cr1
107c1s0bA_



not modelled 77.9 35 PDB header:toxin, hydrolase
Chain: A: PDB Molecule:botulinum neurotoxin type b;
PDBTitle: crystal structure of botulinum neurotoxin type b at ph 4.0
108c2v4bB_



not modelled 77.1 31 PDB header:hydrolase
Chain: B: PDB Molecule:adamts-1;
PDBTitle: crystal structure of human adamts-1 catalytic domain and2 cysteine-rich domain (apo-form)
109c3zurA_



not modelled 76.5 24 PDB header:hydrolase/signaling protein
Chain: A: PDB Molecule:botulinum neurotoxin type a, synaptosomal-associated
PDBTitle: crystal structure of an engineered botulinum neurotoxin2 type a-snare23 derivative, lc0-a-snap25-hn-a
110c1eakA_



not modelled 70.2 33 PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:72 kda type iv collagenase;
PDBTitle: catalytic domain of prommp-2 e404q mutant
111c3cqbB_



not modelled 70.1 33 PDB header:hydrolase
Chain: B: PDB Molecule:probable protease htpx homolog;
PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633
112c3dl1A_



not modelled 70.0 12 PDB header:hydrolase
Chain: A: PDB Molecule:putative metal-dependent hydrolase;
PDBTitle: crystal structure of a putative metal-dependent hydrolase2 (yp_001336084.1) from klebsiella pneumoniae subsp. pneumoniae mgh3 78578 at 2.20 a resolution
113d1c7ka_



not modelled 66.8 40 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Zinc protease
114c3iukB_



not modelled 66.8 14 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of putative bacterial protein of unknown function2 (duf885, pf05960.1, ) from arthrobacter aurescens tc1, reveals fold3 similar to that of m32 carboxypeptidases
115c3p1vB_



not modelled 65.7 36 PDB header:hydrolase
Chain: B: PDB Molecule:metallo-endopeptidase;
PDBTitle: crystal structure of a metallo-endopeptidases (bacova_00663) from2 bacteroides ovatus at 1.93 a resolution
116c3c37B_



not modelled 64.8 31 PDB header:hydrolase
Chain: B: PDB Molecule:peptidase, m48 family;
PDBTitle: x-ray structure of the putative zn-dependent peptidase q74d82 at the2 resolution 1.7 a. northeast structural genomics consortium target3 gsr143a
117c1l6jA_



not modelled 60.6 50 PDB header:hydrolase
Chain: A: PDB Molecule:matrix metalloproteinase-9;
PDBTitle: crystal structure of human matrix metalloproteinase mmp92 (gelatinase b).
118c1gxdA_



not modelled 54.1 33 PDB header:hydrolase
Chain: A: PDB Molecule:72 kda type iv collagenase;
PDBTitle: prommp-2/timp-2 complex
119d1lmla_



not modelled 51.7 12 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Leishmanolysin
120c3cskA_



not modelled 47.8 58 PDB header:hydrolase
Chain: A: PDB Molecule:probable dipeptidyl-peptidase 3;
PDBTitle: structure of dpp iii from saccharomyces cerevisiae

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction 

Transmembrane helices have been predicted in your sequence to adopt the topology shown below



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0