Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	Q	F	Y	S	A	K	R	R	T	T	T	R	Q	I	I	T	V	S	V	N	D	L	D	S	F	G	Q	G	V	A	R	H	N	G	K	T	L	F	I	P	G	L	L	P	Q	E	N	A	E	V	T	V	T	E	D	K	K	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Y	A	R	A	K	V	V	R	R	L	S	D	S	P	E	R	E	T	P	R	C	P	H	F	G	V	C	G	G	C	Q	Q	Q	H	A	S	V	D	L	Q	Q	R	S	K	S	A	A	L	A	R	L	M	K	H	D	V	S	E	V	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	D	V	P	W	G	Y	R	R	R	A	R	L	S	L	N	Y	L	P	K	T	Q	Q	L	Q	M	G	F	R	K	A	G	S	S	D	I	V	D	V	K	Q	C	P	I	L	A	P	Q	L	E	A	L	L	P	K	V	R	A	C	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	S	L	Q	A	M	R	H	L	G	H	V	E	L	V	Q	A	T	S	G	T	L	M	I	L	R	H	T	A	P	L	S	S	A	D	R	E	K	L	E	R	F	S	H	S	E	G	L	D	L	Y	L	A	P	D	S	E	I	L	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	V	S	G	E	M	P	W	Y	D	S	N	G	L	R	L	T	F	S	P	R	D	F	I	Q	V	N	A	G	V	N	Q	K	M	V	A	R	A	L	E	W	L	D	V	Q	P	E	D	R	V	L	D	L	F	C	G	M	G	N	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		T	L	P	L	A	T	Q	A	A	S	V	V	G	V	E	G	V	P	A	L	V	E	K	G	Q	Q	N	A	R	L	N	G	L	Q	N	V	T	F	Y	H	E	N	L	E	E	D	V	T	K	Q	P	W	A	K	N	G	F	D	K	V
Secondary structure
SS confidence
Disorder																																																					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	L	D	P	A	R	A	G	A	A	G	V	M	Q	Q	I	I	K	L	E	P	I	R	I	V	Y	V	S	C	N	P	A	T	L	A	R	D	S	E	A	L	L	K	A	G	Y	T	I	A	R	L	A	M	L	D	M	F	P	H	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.
Sequence		G	H	L	E	S	M	V	L	F	S	R	V	K
Secondary structure
SS confidence
Disorder													?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1uwv chain A Region: 15 - 431 Aligned: 417 Modelled: 417 Confidence: 100.0% Identity: 97% PDB header:transferase Chain: A: PDB Molecule:23s rrna (uracil-5-)-methyltransferase ruma; PDBTitle: crystal structure of ruma, the iron-sulfur cluster2 containing e. coli 23s ribosomal rna 5-methyluridine3 methyltransferase Phyre2 PDB 2vs1 chain A Region: 14 - 429 Aligned: 380 Modelled: 416 Confidence: 100.0% Identity: 27% PDB header:transferase Chain: A: PDB Molecule:uncharacterized rna methyltransferase pyrab10780; PDBTitle: the crystal structure of pyrococcus abyssi trna (uracil-54,2 c5)-methyltransferase in complex with s-adenosyl-l-3 homocysteine Phyre2 PDB 1uwv chain A domain 2 Region: 75 - 431 Aligned: 357 Modelled: 357 Confidence: 100.0% Identity: 97% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: (Uracil-5-)-methyltransferase Phyre2 PDB 3bt7 chain A Region: 91 - 431 Aligned: 335 Modelled: 341 Confidence: 100.0% Identity: 23% PDB header:transferase/rna Chain: A: PDB Molecule:trna (uracil-5-)-methyltransferase; PDBTitle: structure of e. coli 5-methyluridine methyltransferase trma2 in complex with 19 nucleotide t-arm analogue Phyre2 PDB 3c0k chain B Region: 123 - 428 Aligned: 304 Modelled: 306 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:upf0064 protein yccw; PDBTitle: crystal structure of a ribosomal rna methyltranferase Phyre2 PDB 1wxw chain A Region: 121 - 428 Aligned: 300 Modelled: 308 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:hypothetical protein ttha1280; PDBTitle: crystal structure of tt1595, a putative sam-dependent2 methyltransferase from thermus thermophillus hb8 Phyre2 PDB 2b78 chain A Region: 109 - 424 Aligned: 314 Modelled: 316 Confidence: 100.0% Identity: 15% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein smu.776; PDBTitle: a putative sam-dependent methyltransferase from2 streptococcus mutans Phyre2 PDB 2as0 chain A Region: 121 - 431 Aligned: 309 Modelled: 311 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:hypothetical protein ph1915; PDBTitle: crystal structure of ph1915 (apc 5817): a hypothetical rna2 methyltransferase Phyre2 PDB 3dmg chain A Region: 41 - 391 Aligned: 312 Modelled: 315 Confidence: 99.9% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:probable ribosomal rna small subunit methyltransferase; PDBTitle: t. thermophilus 16s rrna n2 g1207 methyltransferase (rsmc) in complex2 with adohcy Phyre2 PDB 2as0 chain A domain 2 Region: 245 - 428 Aligned: 178 Modelled: 184 Confidence: 99.9% Identity: 26% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: hypothetical RNA methyltransferase Phyre2 PDB 1wxx chain A domain 2 Region: 245 - 428 Aligned: 181 Modelled: 184 Confidence: 99.9% Identity: 28% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: hypothetical RNA methyltransferase Phyre2 PDB 3a26 chain A Region: 174 - 431 Aligned: 249 Modelled: 258 Confidence: 99.9% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:uncharacterized protein ph0793; PDBTitle: crystal structure of p. horikoshii tyw2 in complex with2 mesado Phyre2 PDB 2frn chain A domain 1 Region: 199 - 431 Aligned: 216 Modelled: 233 Confidence: 99.9% Identity: 16% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Met-10+ protein-like Phyre2 PDB 2b78 chain A domain 2 Region: 200 - 428 Aligned: 227 Modelled: 229 Confidence: 99.9% Identity: 14% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: hypothetical RNA methyltransferase Phyre2 PDB 2igt chain A domain 1 Region: 244 - 390 Aligned: 147 Modelled: 147 Confidence: 99.9% Identity: 20% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: hypothetical RNA methyltransferase Phyre2 PDB 3a27 chain A Region: 239 - 432 Aligned: 185 Modelled: 194 Confidence: 99.9% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:uncharacterized protein mj1557; PDBTitle: crystal structure of m. jannaschii tyw2 in complex with2 adomet Phyre2 PDB 1wy7 chain A domain 1 Region: 263 - 432 Aligned: 159 Modelled: 170 Confidence: 99.9% Identity: 19% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Ta1320-like Phyre2 PDB 2yxd chain A Region: 260 - 413 Aligned: 148 Modelled: 154 Confidence: 99.9% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:probable cobalt-precorrin-6y c(15)-methyltransferase PDBTitle: crystal structure of cobalamin biosynthesis precorrin 8w decarboxylase2 (cbit) Phyre2 PDB 2yx1 chain A Region: 200 - 431 Aligned: 218 Modelled: 231 Confidence: 99.8% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:hypothetical protein mj0883; PDBTitle: crystal structure of m.jannaschii trna m1g37 methyltransferase Phyre2 PDB 1pry chain A Region: 262 - 427 Aligned: 162 Modelled: 166 Confidence: 99.8% Identity: 15% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Fibrillarin homologue Phyre2 PDB 1yez chain A domain 1 Region: 1 - 68 Aligned: 68 Modelled: 68 Confidence: 99.6% Identity: 25% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: TRAM domain Phyre2 1 c1uwvA_ 2 c2vs1A_ 3 d1uwva2 4 c3bt7A_ 5 c3c0kB_ 6 c1wxwA_ 7 c2b78A_ 8 c2as0A_ 9 c3dmgA_ 10 d2as0a2 11 d1wxxa2 12 c3a26A_ 13 d2frna1 14 d2b78a2 15 d2igta1 16 c3a27A_ 17 d1wy7a1 18 c2yxdA_ 19 c2yx1A_ 20 d1prya_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 d1yeza1 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499