Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	I	E	I	K	V	P	D	I	G	A	D	E	V	E	I	T	E	I	L	V	K	V	G	D	K	V	E	A	E	Q	S	L	I	T	V	E	G	D	K	A	S	M	E	V	P	S	P	Q	A	G	I	V	K	E	I	K	V	S
Secondary structure
SS confidence
Disorder		?	?	?	?			?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	G	D	K	T	Q	T	G	A	L	I	M	I	F	D	S	A	D	G	A	A	D	A	A	P	A	Q	A	E	E	K	K	E	A	A	P	A	A	A	P	A	A	A	A	A	K	D	V	N	V	P	D	I	G	S	D	E	V	E	V
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	E	I	L	V	K	V	G	D	K	V	E	A	E	Q	S	L	I	T	V	E	G	D	K	A	S	M	E	V	P	A	P	F	A	G	T	V	K	E	I	K	V	N	V	G	D	K	V	S	T	G	S	L	I	M	V	F	E	V	A
Secondary structure
SS confidence
Disorder												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	E	A	G	A	A	A	P	A	A	K	Q	E	A	A	P	A	A	A	P	A	P	A	A	G	V	K	E	V	N	V	P	D	I	G	G	D	E	V	E	V	T	E	V	M	V	K	V	G	D	K	V	A	A	E	Q	S	L	I	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?			?	?	?								?	?	?	?	?	?	?													?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	E	G	D	K	A	S	M	E	V	P	A	P	F	A	G	V	V	K	E	L	K	V	N	V	G	D	K	V	K	T	G	S	L	I	M	I	F	E	V	E	G	A	A	P	A	A	A	P	A	K	Q	E	A	A	A	P	A	P	A
Secondary structure
SS confidence
Disorder																																										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	K	A	E	A	P	A	A	A	P	A	A	K	A	E	G	K	S	E	F	A	E	N	D	A	Y	V	H	A	T	P	L	I	R	R	L	A	R	E	F	G	V	N	L	A	K	V	K	G	T	G	R	K	G	R	I	L	R	E	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																						?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	Q	A	Y	V	K	E	A	I	K	R	A	E	A	A	P	A	A	T	G	G	G	I	P	G	M	L	P	W	P	K	V	D	F	S	K	F	G	E	I	E	E	V	E	L	G	R	I	Q	K	I	S	G	A	N	L	S	R	N	W
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		V	M	I	P	H	V	T	H	F	D	K	T	D	I	T	E	L	E	A	F	R	K	Q	Q	N	E	E	A	A	K	R	K	L	D	V	K	I	T	P	V	V	F	I	M	K	A	V	A	A	A	L	E	Q	M	P	R	F	N	S	S
Secondary structure
SS confidence
Disorder																												?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		L	S	E	D	G	Q	R	L	T	L	K	K	Y	I	N	I	G	V	A	V	D	T	P	N	G	L	V	V	P	V	F	K	D	V	N	K	K	G	I	I	E	L	S	R	E	L	M	T	I	S	K	K	A	R	D	G	K	L	T	A
Secondary structure
SS confidence
Disorder																																																								?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		G	E	M	Q	G	G	C	F	T	I	S	S	I	G	G	L	G	T	T	H	F	A	P	I	V	N	A	P	E	V	A	I	L	G	V	S	K	S	A	M	E	P	V	W	N	G	K	E	F	V	P	R	L	M	L	P	I	S	L	S
Secondary structure
SS confidence
Disorder				?	?	?											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence		F	D	H	R	V	I	D	G	A	D	G	A	R	F	I	T	I	I	N	N	T	L	S	D	I	R	R	L	V	M
Secondary structure
SS confidence
Disorder																														?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1dpb chain A Region: 387 - 630 Aligned: 242 Modelled: 244 Confidence: 100.0% Identity: 55% Fold: CoA-dependent acyltransferases Superfamily: CoA-dependent acyltransferases Family: CAT-like Phyre2 PDB 1b5s chain A Region: 387 - 630 Aligned: 242 Modelled: 244 Confidence: 100.0% Identity: 38% Fold: CoA-dependent acyltransferases Superfamily: CoA-dependent acyltransferases Family: CAT-like Phyre2 PDB 2ii4 chain C Region: 398 - 630 Aligned: 230 Modelled: 233 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: C: PDB Molecule:lipoamide acyltransferase component of branched-chain PDBTitle: crystal structure of a cubic core of the dihydrolipoamide2 acyltransferase (e2b) component in the branched-chain alpha-ketoacid3 dehydrogenase complex (bckdc), coenzyme a-bound form Phyre2 PDB 3l60 chain A Region: 400 - 630 Aligned: 225 Modelled: 231 Confidence: 100.0% Identity: 28% PDB header:oxidoreductase Chain: A: PDB Molecule:branched-chain alpha-keto acid dehydrogenase; PDBTitle: crystal structure of branched-chain alpha-keto acid2 dehydrogenase subunit e2 from mycobacterium tuberculosis Phyre2 PDB 3b8k chain A Region: 389 - 630 Aligned: 237 Modelled: 242 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase; PDBTitle: structure of the truncated human dihydrolipoyl2 acetyltransferase (e2) Phyre2 PDB 1scz chain A Region: 397 - 630 Aligned: 231 Modelled: 234 Confidence: 100.0% Identity: 32% Fold: CoA-dependent acyltransferases Superfamily: CoA-dependent acyltransferases Family: CAT-like Phyre2 PDB 3mae chain A Region: 397 - 627 Aligned: 228 Modelled: 231 Confidence: 100.0% Identity: 31% PDB header:transferase Chain: A: PDB Molecule:2-oxoisovalerate dehydrogenase e2 component, PDBTitle: crystal structure of probable dihydrolipamide2 acetyltransferase from listeria monocytogenes 4b f2365 Phyre2 PDB 1q23 chain A Region: 419 - 625 Aligned: 186 Modelled: 205 Confidence: 100.0% Identity: 13% Fold: CoA-dependent acyltransferases Superfamily: CoA-dependent acyltransferases Family: CAT-like Phyre2 PDB 3cla chain A Region: 419 - 627 Aligned: 188 Modelled: 209 Confidence: 100.0% Identity: 18% Fold: CoA-dependent acyltransferases Superfamily: CoA-dependent acyltransferases Family: CAT-like Phyre2 PDB 2i9d chain C Region: 396 - 623 Aligned: 190 Modelled: 228 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: C: PDB Molecule:chloramphenicol acetyltransferase; PDBTitle: chloramphenicol acetyltransferase Phyre2 PDB 2dne chain A Region: 2 - 82 Aligned: 81 Modelled: 81 Confidence: 99.7% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase PDBTitle: solution structure of rsgi ruh-058, a lipoyl domain of2 human 2-oxoacid dehydrogenase Phyre2 PDB 2xt6 chain B Region: 429 - 624 Aligned: 133 Modelled: 151 Confidence: 99.6% Identity: 28% PDB header:lyase Chain: B: PDB Molecule:2-oxoglutarate decarboxylase; PDBTitle: crystal structure of mycobacterium smegmatis alpha-ketoglutarate2 decarboxylase homodimer (orthorhombic form) Phyre2 PDB 2dnc chain A Region: 1 - 78 Aligned: 78 Modelled: 78 Confidence: 99.6% Identity: 29% PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase protein x component; PDBTitle: solution structure of rsgi ruh-054, a lipoyl domain from2 human 2-oxoacid dehydrogenase Phyre2 PDB 2l5t chain A Region: 3 - 76 Aligned: 74 Modelled: 74 Confidence: 99.6% Identity: 38% PDB header:transferase Chain: A: PDB Molecule:lipoamide acyltransferase; PDBTitle: solution nmr structure of e2 lipoyl domain from thermoplasma2 acidophilum Phyre2 PDB 1qjo chain A Region: 1 - 76 Aligned: 76 Modelled: 76 Confidence: 99.6% Identity: 75% Fold: Barrel-sandwich hybrid Superfamily: Single hybrid motif Family: Biotinyl/lipoyl-carrier proteins and domains Phyre2 PDB 1k8m chain A Region: 1 - 76 Aligned: 76 Modelled: 76 Confidence: 99.6% Identity: 30% Fold: Barrel-sandwich hybrid Superfamily: Single hybrid motif Family: Biotinyl/lipoyl-carrier proteins and domains Phyre2 PDB 1ghj chain A Region: 2 - 76 Aligned: 75 Modelled: 75 Confidence: 99.6% Identity: 28% Fold: Barrel-sandwich hybrid Superfamily: Single hybrid motif Family: Biotinyl/lipoyl-carrier proteins and domains Phyre2 PDB 2q8i chain B Region: 3 - 78 Aligned: 76 Modelled: 76 Confidence: 99.6% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase component of PDBTitle: pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug2 radicicol Phyre2 PDB 1y8o chain B domain 1 Region: 3 - 78 Aligned: 76 Modelled: 76 Confidence: 99.6% Identity: 21% Fold: Barrel-sandwich hybrid Superfamily: Single hybrid motif Family: Biotinyl/lipoyl-carrier proteins and domains Phyre2 PDB 1iyu chain A Region: 2 - 78 Aligned: 76 Modelled: 77 Confidence: 99.5% Identity: 50% Fold: Barrel-sandwich hybrid Superfamily: Single hybrid motif Family: Biotinyl/lipoyl-carrier proteins and domains Phyre2 PDB 2coo chain A Region: 312 - 381 Aligned: 70 Modelled: 70 Confidence: 99.2% Identity: 29% PDB header:transferase Chain: A: PDB Molecule:lipoamide acyltransferase component of branched- PDBTitle: solution structure of the e3_binding domain of2 dihydrolipoamide branched chaintransacylase Phyre2 PDB 1zwv chain A Region: 323 - 370 Aligned: 48 Modelled: 48 Confidence: 99.1% Identity: 40% PDB header:transferase Chain: A: PDB Molecule:lipoamide acyltransferase component of branched- PDBTitle: solution structure of the subunit binding domain (hbsbd) of2 the human mitochondrial branched-chain alpha-ketoacid3 dehydrogenase Phyre2 PDB 1w4k chain A Region: 324 - 373 Aligned: 50 Modelled: 50 Confidence: 99.1% Identity: 44% PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase e2; PDBTitle: peripheral-subunit binding domains from mesophilic,2 thermophilic, and hyperthermophilic bacteria fold by3 ultrafast, apparently two-state transitions Phyre2 PDB 1w3d chain A Region: 324 - 368 Aligned: 45 Modelled: 45 Confidence: 99.1% Identity: 42% PDB header:transferase Chain: A: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase PDBTitle: nmr structure of the peripheral-subunit binding domain of2 bacillus stearothermophilus e2p Phyre2 PDB 2eq9 chain C Region: 327 - 366 Aligned: 40 Modelled: 40 Confidence: 99.1% Identity: 45% PDB header:oxidoreductase Chain: C: PDB Molecule:pyruvate dehydrogenase complex, dihydrolipoamide PDBTitle: crystal structure of lipoamide dehydrogenase from thermus thermophilus2 hb8 with psbdb Phyre2 PDB 1w85 chain I Region: 326 - 367 Aligned: 42 Modelled: 42 Confidence: 99.1% Identity: 45% Fold: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Superfamily: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Family: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Phyre2 PDB 2f1m chain A Region: 32 - 149 Aligned: 117 Modelled: 117 Confidence: 99.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:acriflavine resistance protein a; PDBTitle: conformational flexibility in the multidrug efflux system protein acra Phyre2 PDB 3fpp chain B Region: 23 - 173 Aligned: 150 Modelled: 150 Confidence: 98.9% Identity: 19% PDB header:membrane protein Chain: B: PDB Molecule:macrolide-specific efflux protein maca; PDBTitle: crystal structure of e.coli maca Phyre2 PDB 1t5e chain B Region: 32 - 136 Aligned: 104 Modelled: 104 Confidence: 98.9% Identity: 15% PDB header:transport protein Chain: B: PDB Molecule:multidrug resistance protein mexa; PDBTitle: the structure of mexa Phyre2 PDB 1vf7 chain A Region: 43 - 136 Aligned: 94 Modelled: 94 Confidence: 98.8% Identity: 17% Fold: HlyD-like secretion proteins Superfamily: HlyD-like secretion proteins Family: HlyD-like secretion proteins Phyre2 PDB 3h9i chain B Region: 17 - 282 Aligned: 147 Modelled: 147 Confidence: 98.7% Identity: 20% PDB header:transport protein Chain: B: PDB Molecule:cation efflux system protein cusb; PDBTitle: crystal structure of the membrane fusion protein cusb from escherichia2 coli Phyre2 PDB 3lnn chain B Region: 40 - 151 Aligned: 108 Modelled: 108 Confidence: 98.6% Identity: 19% PDB header:metal transport Chain: B: PDB Molecule:membrane fusion protein (mfp) heavy metal cation efflux PDBTitle: crystal structure of zneb from cupriavidus metallidurans Phyre2 PDB 2k33 chain A Region: 43 - 293 Aligned: 113 Modelled: 113 Confidence: 98.6% Identity: 23% PDB header:membrane protein, transport protein Chain: A: PDB Molecule:acra; PDBTitle: solution structure of an n-glycosylated protein using in2 vitro glycosylation Phyre2 1 d1dpba_ 2 d1b5sa_ 3 c2ii4C_ 4 c3l60A_ 5 c3b8kA_ 6 d1scza_ 7 c3maeA_ 8 d1q23a_ 9 d3claa_ 10 c2i9dC_ 11 c2dneA_ 12 c2xt6B_ 13 c2dncA_ 14 c2l5tA_ 15 d1qjoa_ 16 d1k8ma_ 17 d1ghja_ 18 c2q8iB_ 19 d1y8ob1 20 d1iyua_ 21 22 23 24 25 c2cooA_ 26 27 28 29 30 31 c1zwvA_ 32 c1w4kA_ 33 c1w3dA_ 34 c2eq9C_ 35 36 d1w85i_ 37 38 c2f1mA_ 39 40 41 42 43 44 45 46 c3fppB_ 47 c1t5eB_ 48 49 d1vf7a_ 50 c3h9iB_ 51 c3lnnB_ 52 c2k33A_ 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128