Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	V	F	S	L	K	I	D	I	A	D	N	K	F	F	N	G	E	T	S	P	L	F	S	Q	S	Q	A	K	L	A	R	Q	F	H	Q	K	I	A	G	Y	R	P	T	P	L	C	A	L	D	D	L	A	N	L	F	G	V	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?					?	?	?	?			?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	I	L	V	K	D	E	S	K	R	F	G	L	N	A	F	K	M	L	G	G	A	Y	A	I	A	Q	L	L	C	E	K	Y	H	L	D	I	E	T	L	S	F	E	H	L	K	N	A	I	G	E	K	M	T	F	A	T	T	T	D
Secondary structure
SS confidence
Disorder																																	?	?	?	?				?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	N	H	G	R	G	V	A	W	A	A	Q	Q	L	G	Q	N	A	V	I	Y	M	P	K	G	S	A	Q	E	R	V	D	A	I	L	N	L	G	A	E	C	I	V	T	D	M	N	Y	D	D	T	V	R	L	T	M	Q	H	A	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Q	H	G	W	E	V	V	Q	D	T	A	W	E	G	Y	T	K	I	P	T	W	I	M	Q	G	Y	A	T	L	A	D	E	A	V	E	Q	M	R	E	M	G	V	T	P	T	H	V	L	L	Q	A	G	V	G	A	M	A	G	G	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	G	Y	L	V	D	V	Y	S	P	Q	N	L	H	S	I	I	V	E	P	D	K	A	D	C	I	Y	R	S	G	V	K	G	D	I	V	N	V	G	G	D	M	A	T	I	M	A	G	L	A	C	G	E	P	N	P	L	G	W	E
Secondary structure
SS confidence
Disorder																																				?		?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		I	L	R	N	C	A	T	Q	F	I	S	C	Q	D	S	V	A	A	L	G	M	R	V	L	G	N	P	Y	G	N	D	P	R	I	I	S	G	E	S	G	A	V	G	L	G	V	L	A	A	V	H	Y	H	P	Q	R	Q	S	L	M
Secondary structure
SS confidence
Disorder																																																							?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.
Sequence		E	K	L	A	L	N	K	D	A	V	V	L	V	I	S	T	E	G	D	T	D	V	K	H	Y	R	E	V	V	W	E	G	K	H	A	V	A	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?																												?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1tdj chain A Region: 19 - 392 Aligned: 326 Modelled: 349 Confidence: 100.0% Identity: 23% PDB header:allostery Chain: A: PDB Molecule:biosynthetic threonine deaminase; PDBTitle: threonine deaminase (biosynthetic) from e. coli Phyre2 PDB 3r0z chain A Region: 19 - 393 Aligned: 359 Modelled: 375 Confidence: 100.0% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:d-serine dehydratase; PDBTitle: crystal structure of apo d-serine deaminase from salmonella2 typhimurium Phyre2 PDB 3l6c chain A Region: 21 - 383 Aligned: 317 Modelled: 341 Confidence: 100.0% Identity: 20% PDB header:isomerase Chain: A: PDB Molecule:serine racemase; PDBTitle: x-ray crystal structure of rat serine racemase in complex with2 malonate a potent inhibitor Phyre2 PDB 3iau chain A Region: 37 - 390 Aligned: 305 Modelled: 329 Confidence: 100.0% Identity: 23% PDB header:lyase Chain: A: PDB Molecule:threonine deaminase; PDBTitle: the structure of the processed form of threonine deaminase isoform 22 from solanum lycopersicum Phyre2 PDB 1v71 chain A domain 1 Region: 23 - 391 Aligned: 317 Modelled: 344 Confidence: 100.0% Identity: 21% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1pwh chain A Region: 42 - 391 Aligned: 310 Modelled: 331 Confidence: 100.0% Identity: 19% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 2gn0 chain A Region: 24 - 390 Aligned: 316 Modelled: 341 Confidence: 100.0% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:threonine dehydratase catabolic; PDBTitle: crystal structure of dimeric biodegradative threonine deaminase (tdcb)2 from salmonella typhimurium at 1.7 a resolution (triclinic form with3 one complete subunit built in alternate conformation) Phyre2 PDB 1ve5 chain A domain 1 Region: 30 - 381 Aligned: 301 Modelled: 318 Confidence: 100.0% Identity: 25% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1p5j chain A Region: 40 - 391 Aligned: 312 Modelled: 333 Confidence: 100.0% Identity: 20% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1p5j chain A Region: 40 - 391 Aligned: 312 Modelled: 333 Confidence: 100.0% Identity: 20% PDB header:lyase Chain: A: PDB Molecule:l-serine dehydratase; PDBTitle: crystal structure analysis of human serine dehydratase Phyre2 PDB 1tdj chain A domain 1 Region: 21 - 390 Aligned: 322 Modelled: 345 Confidence: 100.0% Identity: 23% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 2rkb chain E Region: 40 - 389 Aligned: 310 Modelled: 331 Confidence: 100.0% Identity: 22% PDB header:lyase Chain: E: PDB Molecule:serine dehydratase-like; PDBTitle: serine dehydratase like-1 from human cancer cells Phyre2 PDB 1x1q chain A Region: 25 - 390 Aligned: 328 Modelled: 348 Confidence: 100.0% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase beta chain; PDBTitle: crystal structure of tryptophan synthase beta chain from thermus2 thermophilus hb8 Phyre2 PDB 1v8z chain A domain 1 Region: 25 - 390 Aligned: 328 Modelled: 348 Confidence: 100.0% Identity: 22% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1qop chain B Region: 32 - 389 Aligned: 321 Modelled: 340 Confidence: 100.0% Identity: 21% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1jbq chain D Region: 4 - 385 Aligned: 331 Modelled: 364 Confidence: 100.0% Identity: 20% PDB header:lyase Chain: D: PDB Molecule:cystathionine beta-synthase; PDBTitle: structure of human cystathionine beta-synthase: a unique pyridoxal 5'-2 phosphate dependent hemeprotein Phyre2 PDB 1jbq chain A Region: 4 - 385 Aligned: 331 Modelled: 364 Confidence: 100.0% Identity: 20% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1e5x chain A Region: 41 - 383 Aligned: 291 Modelled: 329 Confidence: 100.0% Identity: 13% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 3pc3 chain A Region: 38 - 390 Aligned: 304 Modelled: 335 Confidence: 100.0% Identity: 19% PDB header:lyase Chain: A: PDB Molecule:cg1753, isoform a; PDBTitle: full length structure of cystathionine beta-synthase from drosophila2 in complex with aminoacrylate Phyre2 PDB 2d1f chain A Region: 37 - 391 Aligned: 304 Modelled: 329 Confidence: 100.0% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:threonine synthase; PDBTitle: structure of mycobacterium tuberculosis threonine synthase Phyre2 1 c1tdjA_ 2 c3r0zA_ 3 c3l6cA_ 4 c3iauA_ 5 d1v71a1 6 d1pwha_ 7 c2gn0A_ 8 d1ve5a1 9 d1p5ja_ 10 c1p5jA_ 11 d1tdja1 12 c2rkbE_ 13 c1x1qA_ 14 d1v8za1 15 d1qopb_ 16 c1jbqD_ 17 d1jbqa_ 18 d1e5xa_ 19 c3pc3A_ 20 c2d1fA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1tdjA_ 100.0 23 PDB header:allostery Chain: A: PDB Molecule:biosynthetic threonine deaminase; PDBTitle: threonine deaminase (biosynthetic) from e. coli 2 c3r0zA_ 100.0 18 PDB header:lyase Chain: A: PDB Molecule:d-serine dehydratase; PDBTitle: crystal structure of apo d-serine deaminase from salmonella2 typhimurium 3 c3l6cA_ 100.0 20 PDB header:isomerase Chain: A: PDB Molecule:serine racemase; PDBTitle: x-ray crystal structure of rat serine racemase in complex with2 malonate a potent inhibitor 4 c3iauA_ 100.0 23 PDB header:lyase Chain: A: PDB Molecule:threonine deaminase; PDBTitle: the structure of the processed form of threonine deaminase isoform 22 from solanum lycopersicum 5 d1v71a1 100.0 21 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 6 d1pwha_ 100.0 19 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 7 c2gn0A_ 100.0 18 PDB header:lyase Chain: A: PDB Molecule:threonine dehydratase catabolic; PDBTitle: crystal structure of dimeric biodegradative threonine deaminase (tdcb)2 from salmonella typhimurium at 1.7 a resolution (triclinic form with3 one complete subunit built in alternate conformation) 8 d1ve5a1 100.0 25 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 9 d1p5ja_ 100.0 20 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 10 c1p5jA_ 100.0 20 PDB header:lyase Chain: A: PDB Molecule:l-serine dehydratase; PDBTitle: crystal structure analysis of human serine dehydratase 11 d1tdja1 100.0 23 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 12 c2rkbE_ 100.0 22 PDB header:lyase Chain: E: PDB Molecule:serine dehydratase-like; PDBTitle: serine dehydratase like-1 from human cancer cells 13 c1x1qA_ 100.0 21 PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase beta chain; PDBTitle: crystal structure of tryptophan synthase beta chain from thermus2 thermophilus hb8 14 d1v8za1 100.0 22 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 15 d1qopb_ 100.0 21 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 16 c1jbqD_ 100.0 20 PDB header:lyase Chain: D: PDB Molecule:cystathionine beta-synthase; PDBTitle: structure of human cystathionine beta-synthase: a unique pyridoxal 5'-2 phosphate dependent hemeprotein 17 d1jbqa_ 100.0 20 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 18 d1e5xa_ 100.0 13 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 19 c3pc3A_ 100.0 19 PDB header:lyase Chain: A: PDB Molecule:cg1753, isoform a; PDBTitle: full length structure of cystathionine beta-synthase from drosophila2 in complex with aminoacrylate 20 c2d1fA_ 100.0 18 PDB header:lyase Chain: A: PDB Molecule:threonine synthase; PDBTitle: structure of mycobacterium tuberculosis threonine synthase 21 d1v7ca_ not modelled 100.0 19 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 22 c2zsjB_ not modelled 100.0 19 PDB header:lyase Chain: B: PDB Molecule:threonine synthase; PDBTitle: crystal structure of threonine synthase from aquifex aeolicus vf5 23 d1wkva1 not modelled 100.0 19 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 24 d1ve1a1 not modelled 100.0 22 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 25 d1y7la1 not modelled 100.0 16 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 26 c2pqmA_ not modelled 100.0 20 PDB header:lyase Chain: A: PDB Molecule:cysteine synthase; PDBTitle: crystal structure of cysteine synthase (oass) from entamoeba2 histolytica at 1.86 a resolution 27 d1z7wa1 not modelled 100.0 18 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 28 d2bhsa1 not modelled 100.0 23 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 29 d1fcja_ not modelled 100.0 21 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 30 c3dwgA_ not modelled 100.0 20 PDB header:transferase Chain: A: PDB Molecule:cysteine synthase b; PDBTitle: crystal structure of a sulfur carrier protein complex found in the2 cysteine biosynthetic pathway of mycobacterium tuberculosis 31 c2o2jA_ not modelled 100.0 24 PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase beta chain; PDBTitle: mycobacterium tuberculosis tryptophan synthase beta chain2 dimer (apoform) 32 d1o58a_ not modelled 100.0 21 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 33 c2q3bA_ not modelled 100.0 19 PDB header:transferase Chain: A: PDB Molecule:cysteine synthase a; PDBTitle: 1.8 a resolution crystal structure of o-acetylserine sulfhydrylase2 (oass) holoenzyme from mycobacterium tuberculosis 34 d1f2da_ not modelled 100.0 16 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 35 c2eguA_ not modelled 100.0 25 PDB header:transferase Chain: A: PDB Molecule:cysteine synthase; PDBTitle: crystal structure of o-acetylserine sulfhydrase from geobacillus2 kaustophilus hta426 36 d1tyza_ not modelled 100.0 16 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 37 d1j0aa_ not modelled 100.0 17 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 38 d1vb3a1 not modelled 100.0 21 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 39 c3v7nA_ not modelled 100.0 14 PDB header:lyase Chain: A: PDB Molecule:threonine synthase; PDBTitle: crystal structure of threonine synthase (thrc) from from burkholderia2 thailandensis 40 d1kl7a_ not modelled 100.0 12 Fold:Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily:Tryptophan synthase beta subunit-like PLP-dependent enzymes Family:Tryptophan synthase beta subunit-like PLP-dependent enzymes 41 d1vp8a_ not modelled 89.9 13 Fold:Pyruvate kinase C-terminal domain-like Superfamily:PK C-terminal domain-like Family:MTH1675-like 42 c3iupB_ not modelled 89.5 15 PDB header:oxidoreductase Chain: B: PDB Molecule:putative nadph:quinone oxidoreductase; PDBTitle: crystal structure of putative nadph:quinone oxidoreductase2 (yp_296108.1) from ralstonia eutropha jmp134 at 1.70 a resolution 43 d1c1da1 not modelled 89.4 22 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain 44 d1l7da1 not modelled 88.9 13 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 45 c3dzbA_ not modelled 85.9 11 PDB header:biosynthetic protein Chain: A: PDB Molecule:prephenate dehydrogenase; PDBTitle: crystal structure of prephenate dehydrogenase from streptococcus2 thermophilus 46 d1o8ca2 not modelled 85.5 19 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 47 d1ml4a2 not modelled 84.6 13 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 48 c3k96B_ not modelled 82.8 15 PDB header:oxidoreductase Chain: B: PDB Molecule:glycerol-3-phosphate dehydrogenase [nad(p)+]; PDBTitle: 2.1 angstrom resolution crystal structure of glycerol-3-phosphate2 dehydrogenase (gpsa) from coxiella burnetii 49 c2csuB_ not modelled 81.6 15 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:457aa long hypothetical protein; PDBTitle: crystal structure of ph0766 from pyrococcus horikoshii ot3 50 d1o89a2 not modelled 79.4 14 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 51 c3pefA_ not modelled 79.1 23 PDB header:oxidoreductase Chain: A: PDB Molecule:6-phosphogluconate dehydrogenase, nad-binding; PDBTitle: crystal structure of gamma-hydroxybutyrate dehydrogenase from2 geobacter metallireducens in complex with nadp+ 52 c3krtC_ not modelled 78.6 18 PDB header:oxidoreductase Chain: C: PDB Molecule:crotonyl coa reductase; PDBTitle: crystal structure of putative crotonyl coa reductase from streptomyces2 coelicolor a3(2) 53 c3cumA_ not modelled 76.9 21 PDB header:oxidoreductase Chain: A: PDB Molecule:probable 3-hydroxyisobutyrate dehydrogenase; PDBTitle: crystal structure of a possible 3-hydroxyisobutyrate dehydrogenase2 from pseudomonas aeruginosa pao1 54 c2rgwD_ not modelled 76.7 12 PDB header:transferase Chain: D: PDB Molecule:aspartate carbamoyltransferase; PDBTitle: catalytic subunit of m. jannaschii aspartate2 transcarbamoylase 55 d1ekxa2 not modelled 74.8 14 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 56 c3pduF_ not modelled 74.3 17 PDB header:oxidoreductase Chain: F: PDB Molecule:3-hydroxyisobutyrate dehydrogenase family protein; PDBTitle: crystal structure of gamma-hydroxybutyrate dehydrogenase from2 geobacter sulfurreducens in complex with nadp+ 57 c2vhyB_ not modelled 72.5 13 PDB header:oxidoreductase Chain: B: PDB Molecule:alanine dehydrogenase; PDBTitle: crystal structure of apo l-alanine dehydrogenase from2 mycobacterium tuberculosis 58 c3eywA_ not modelled 72.4 13 PDB header:transport protein Chain: A: PDB Molecule:c-terminal domain of glutathione-regulated potassium-efflux PDBTitle: crystal structure of the c-terminal domain of e. coli kefc in complex2 with keff 59 d1bg6a2 not modelled 72.2 23 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:6-phosphogluconate dehydrogenase-like, N-terminal domain 60 c1ml4A_ not modelled 72.0 16 PDB header:transferase Chain: A: PDB Molecule:aspartate transcarbamoylase; PDBTitle: the pala-liganded aspartate transcarbamoylase catalytic subunit from2 pyrococcus abyssi 61 d1wdka3 not modelled 71.0 17 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:6-phosphogluconate dehydrogenase-like, N-terminal domain 62 c2g5cD_ not modelled 70.2 19 PDB header:oxidoreductase Chain: D: PDB Molecule:prephenate dehydrogenase; PDBTitle: crystal structure of prephenate dehydrogenase from aquifex aeolicus 63 c2eghA_ not modelled 66.7 22 PDB header:oxidoreductase Chain: A: PDB Molecule:1-deoxy-d-xylulose 5-phosphate reductoisomerase; PDBTitle: crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase2 complexed with a magnesium ion, nadph and fosmidomycin 64 c2bruB_ not modelled 65.9 19 PDB header:oxidoreductase Chain: B: PDB Molecule:nad(p) transhydrogenase subunit alpha; PDBTitle: complex of the domain i and domain iii of escherichia coli2 transhydrogenase 65 d1otha2 not modelled 64.6 16 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 66 c2vq3B_ not modelled 63.2 17 PDB header:oxidoreductase Chain: B: PDB Molecule:metalloreductase steap3; PDBTitle: crystal structure of the membrane proximal oxidoreductase2 domain of human steap3, the dominant ferric reductase of3 the erythroid transferrin cycle 67 d3cuma2 not modelled 63.2 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:6-phosphogluconate dehydrogenase-like, N-terminal domain 68 c3grkE_ not modelled 62.1 14 PDB header:oxidoreductase Chain: E: PDB Molecule:enoyl-(acyl-carrier-protein) reductase (nadh); PDBTitle: crystal structure of short chain dehydrogenase reductase2 sdr glucose-ribitol dehydrogenase from brucella melitensis 69 c2q2qG_ not modelled 60.8 17 PDB header:oxidoreductase Chain: G: PDB Molecule:beta-d-hydroxybutyrate dehydrogenase; PDBTitle: structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida 70 c3d4oA_ not modelled 60.7 19 PDB header:oxidoreductase Chain: A: PDB Molecule:dipicolinate synthase subunit a; PDBTitle: crystal structure of dipicolinate synthase subunit a (np_243269.1)2 from bacillus halodurans at 2.10 a resolution 71 d1n1ea2 not modelled 60.2 13 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:6-phosphogluconate dehydrogenase-like, N-terminal domain 72 c3ktdC_ not modelled 60.1 10 PDB header:oxidoreductase Chain: C: PDB Molecule:prephenate dehydrogenase; PDBTitle: crystal structure of a putative prephenate dehydrogenase (cgl0226)2 from corynebacterium glutamicum atcc 13032 at 2.60 a resolution 73 c1pjcA_ not modelled 59.8 16 PDB header:oxidoreductase Chain: A: PDB Molecule:protein (l-alanine dehydrogenase); PDBTitle: l-alanine dehydrogenase complexed with nad 74 c1m67A_ not modelled 59.7 12 PDB header:oxidoreductase Chain: A: PDB Molecule:glycerol-3-phosphate dehydrogenase; PDBTitle: crystal structure of leishmania mexicana gpdh complexed with inhibitor2 2-bromo-6-hydroxy-purine 75 c1vpdA_ not modelled 59.3 22 PDB header:oxidoreductase Chain: A: PDB Molecule:tartronate semialdehyde reductase; PDBTitle: x-ray crystal structure of tartronate semialdehyde reductase2 [salmonella typhimurium lt2] 76 c3ezlA_ not modelled 58.9 13 PDB header:oxidoreductase Chain: A: PDB Molecule:acetoacetyl-coa reductase; PDBTitle: crystal structure of acetyacetyl-coa reductase from2 burkholderia pseudomallei 1710b 77 c1l7eC_ not modelled 58.2 14 PDB header:oxidoreductase Chain: C: PDB Molecule:nicotinamide nucleotide transhydrogenase, PDBTitle: crystal structure of r. rubrum transhydrogenase domain i2 with bound nadh 78 d1tt7a2 not modelled 57.7 20 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 79 c3ga7A_ not modelled 57.6 10 PDB header:hydrolase Chain: A: PDB Molecule:acetyl esterase; PDBTitle: 1.55 angstrom crystal structure of an acetyl esterase from salmonella2 typhimurium 80 c3l6dB_ not modelled 57.4 16 PDB header:oxidoreductase Chain: B: PDB Molecule:putative oxidoreductase; PDBTitle: crystal structure of putative oxidoreductase from pseudomonas putida2 kt2440 81 c3ggpA_ not modelled 54.8 19 PDB header:oxidoreductase Chain: A: PDB Molecule:prephenate dehydrogenase; PDBTitle: crystal structure of prephenate dehydrogenase from a. aeolicus in2 complex with hydroxyphenyl propionate and nad+ 82 c1m75B_ not modelled 54.4 19 PDB header:oxidoreductase Chain: B: PDB Molecule:3-hydroxyacyl-coa dehydrogenase; PDBTitle: crystal structure of the n208s mutant of l-3-hydroxyacyl-2 coa dehydrogenase in complex with nad and acetoacetyl-coa 83 c3p2yA_ not modelled 53.7 14 PDB header:oxidoreductase Chain: A: PDB Molecule:alanine dehydrogenase/pyridine nucleotide transhydrogenase; PDBTitle: crystal structure of alanine dehydrogenase/pyridine nucleotide2 transhydrogenase from mycobacterium smegmatis 84 c3oj0A_ not modelled 53.6 8 PDB header:oxidoreductase Chain: A: PDB Molecule:glutamyl-trna reductase; PDBTitle: crystal structure of glutamyl-trna reductase from thermoplasma2 volcanium (nucleotide binding domain) 85 c1vlvA_ not modelled 53.4 21 PDB header:transferase Chain: A: PDB Molecule:ornithine carbamoyltransferase; PDBTitle: crystal structure of ornithine carbamoyltransferase (tm1097) from2 thermotoga maritima at 2.25 a resolution 86 d1vpda2 not modelled 53.3 22 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:6-phosphogluconate dehydrogenase-like, N-terminal domain 87 d1trba1 not modelled 53.1 15 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 88 c3uf0A_ not modelled 53.0 14 PDB header:oxidoreductase Chain: A: PDB Molecule:short-chain dehydrogenase/reductase sdr; PDBTitle: crystal structure of a putative nad(p) dependent gluconate 5-2 dehydrogenase from beutenbergia cavernae(efi target efi-502044) with3 bound nadp (low occupancy) 89 c2qx7A_ not modelled 52.6 16 PDB header:plant protein Chain: A: PDB Molecule:eugenol synthase 1; PDBTitle: structure of eugenol synthase from ocimum basilicum 90 d1f0ya2 not modelled 52.4 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:6-phosphogluconate dehydrogenase-like, N-terminal domain 91 c3q98A_ not modelled 52.2 14 PDB header:transferase Chain: A: PDB Molecule:transcarbamylase; PDBTitle: structure of ygew encoded protein from e. coli 92 d1pvva2 not modelled 51.3 18 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 93 d1ja9a_ not modelled 50.5 19 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 94 c3k6jA_ not modelled 50.2 10 PDB header:oxidoreductase Chain: A: PDB Molecule:protein f01g10.3, confirmed by transcript evidence; PDBTitle: crystal structure of the dehydrogenase part of multifuctional enzyme 12 from c.elegans 95 d1pg5a2 not modelled 50.1 11 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 96 d1tuga1 not modelled 49.8 16 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 97 c3mogA_ not modelled 49.6 20 PDB header:oxidoreductase Chain: A: PDB Molecule:probable 3-hydroxybutyryl-coa dehydrogenase; PDBTitle: crystal structure of 3-hydroxybutyryl-coa dehydrogenase from2 escherichia coli k12 substr. mg1655 98 c3c1oA_ not modelled 49.4 12 PDB header:oxidoreductase Chain: A: PDB Molecule:eugenol synthase; PDBTitle: the multiple phenylpropene synthases in both clarkia2 breweri and petunia hybrida represent two distinct lineages 99 c4a10A_ not modelled 49.1 15 PDB header:oxidoreductase Chain: A: PDB Molecule:octenoyl-coa reductase/carboxylase; PDBTitle: apo-structure of 2-octenoyl-coa carboxylase reductase cinf from2 streptomyces sp. 100 d1pjca1 not modelled 48.3 16 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 101 c3d64A_ not modelled 48.1 14 PDB header:hydrolase Chain: A: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of s-adenosyl-l-homocysteine hydrolase from2 burkholderia pseudomallei 102 d1fl2a1 not modelled 48.0 15 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 103 c3iccA_ not modelled 47.5 19 PDB header:oxidoreductase Chain: A: PDB Molecule:putative 3-oxoacyl-(acyl carrier protein) reductase; PDBTitle: crystal structure of a putative 3-oxoacyl-(acyl carrier protein)2 reductase from bacillus anthracis at 1.87 a resolution 104 c1jrxA_ not modelled 46.9 18 PDB header:oxidoreductase Chain: A: PDB Molecule:flavocytochrome c; PDBTitle: crystal structure of arg402ala mutant flavocytochrome c32 from shewanella frigidimarina 105 d1x87a_ not modelled 46.5 17 Fold:Urocanase Superfamily:Urocanase Family:Urocanase 106 c2w62A_ not modelled 46.3 14 PDB header:transferase Chain: A: PDB Molecule:glycolipid-anchored surface protein 2; PDBTitle: saccharomyces cerevisiae gas2p in complex with2 laminaripentaose 107 d1llua2 not modelled 46.3 14 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Alcohol dehydrogenase-like, C-terminal domain 108 c1gthD_ not modelled 46.1 16 PDB header:oxidoreductase Chain: D: PDB Molecule:dihydropyrimidine dehydrogenase; PDBTitle: dihydropyrimidine dehydrogenase (dpd) from pig, ternary2 complex with nadph and 5-iodouracil 109 c3oidA_ not modelled 46.0 24 PDB header:oxidoreductase Chain: A: PDB Molecule:enoyl-[acyl-carrier-protein] reductase [nadph]; PDBTitle: crystal structure of enoyl-acp reductases iii (fabl) from b. subtilis2 (complex with nadp and tcl) 110 c3ed1E_ not modelled 45.9 11 PDB header:hydrolase receptor Chain: E: PDB Molecule:gibberellin receptor gid1; PDBTitle: crystal structure of rice gid1 complexed with ga3 111 d1duvg2 not modelled 45.1 20 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 112 c3k8zD_ not modelled 44.9 17 PDB header:oxidoreductase Chain: D: PDB Molecule:nad-specific glutamate dehydrogenase; PDBTitle: crystal structure of gudb1 a decryptified secondary glutamate2 dehydrogenase from b. subtilis 113 d1hyua1 not modelled 44.8 12 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 114 c3qhaB_ not modelled 44.0 17 PDB header:oxidoreductase Chain: B: PDB Molecule:putative oxidoreductase; PDBTitle: crystal structure of a putative oxidoreductase from mycobacterium2 avium 104 115 c2w37A_ not modelled 43.6 25 PDB header:transferase Chain: A: PDB Molecule:ornithine carbamoyltransferase, catabolic; PDBTitle: crystal structure of the hexameric catabolic ornithine2 transcarbamylase from lactobacillus hilgardii 116 d1vdca1 not modelled 43.4 10 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 117 c3llvA_ not modelled 43.3 12 PDB header:nad(p) binding protein Chain: A: PDB Molecule:exopolyphosphatase-related protein; PDBTitle: the crystal structure of the nad(p)-binding domain of an2 exopolyphosphatase-related protein from archaeoglobus fulgidus to3 1.7a 118 c2p2gD_ not modelled 43.3 16 PDB header:transferase Chain: D: PDB Molecule:ornithine carbamoyltransferase; PDBTitle: crystal structure of ornithine carbamoyltransferase from mycobacterium2 tuberculosis (rv1656): orthorhombic form 119 d1uwka_ not modelled 43.1 22 Fold:Urocanase Superfamily:Urocanase Family:Urocanase 120 c2q1uA_ not modelled 43.0 13 PDB header:sugar binding protein Chain: A: PDB Molecule:putative nucleotide sugar epimerase/ dehydratase; PDBTitle: crystal structure of the bordetella bronchiseptica enzyme wbmf in2 complex with nad+ and udp

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0