Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	A	L	N	S	L	P	L	P	V	V	R	L	L	A	F	F	H	E	E	L	S	E	R	R	P	G	R	V	P	Q	T	V	Q	L	W	V	G	C	L	L	V	I	L	I	S	M	T	F	E	I	P	F	V	A	L	S	L	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?		?	?											?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	L	F	Y	G	I	Q	S	N	A	F	Y	T	K	F	V	A	I	L	F	V	V	A	T	V	L	E	I	G	S	L	F	L	I	Y	K	W	S	Y	G	E	P	L	I	R	L	I	I	A	G	P	I	L	M	G	C	M	F	L	M
Secondary structure
SS confidence
Disorder								?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	T	H	R	L	G	L	V	F	F	A	V	A	I	V	A	I	Y	G	Q	T	F	P	A	M	L	D	Y	P	E	V	V	V	R	L	T	L	W	C	I	V	V	G	L	Y	P	T	L	L	M	T	L	I	G	V	L	W	F	P	S
Secondary structure
SS confidence
Disorder																								?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	A	I	S	Q	M	H	Q	A	L	N	D	R	L	D	D	A	I	S	H	L	T	D	S	L	A	P	L	P	E	T	R	I	E	R	E	A	L	A	L	Q	K	L	N	V	F	C	L	A	D	D	A	N	W	R	T	Q	N	A	W
Secondary structure
SS confidence
Disorder																										?			?	?	?	?	?	?															?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		W	Q	S	C	V	A	T	V	T	Y	I	Y	S	T	L	N	R	Y	D	P	T	S	F	A	D	S	Q	A	I	I	E	F	R	Q	K	L	A	S	E	I	N	K	L	Q	H	A	V	A	E	G	Q	C	W	Q	S	D	W	R	I	S
Secondary structure
SS confidence
Disorder																			?		?	?	?	?	?	?	?	?	?	?	?	?																		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		E	S	E	A	M	A	A	R	E	C	N	L	E	N	I	C	Q	T	L	L	Q	L	G	Q	M	D	P	N	T	P	P	T	P	A	A	K	P	P	S	M	A	A	D	A	F	T	N	P	D	Y	M	R	Y	A	V	K	T	L	L	A
Secondary structure
SS confidence
Disorder					?																					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		C	L	I	C	Y	T	F	Y	S	G	V	D	W	E	G	I	H	T	C	M	L	T	C	V	I	V	A	N	P	N	V	G	S	S	Y	Q	K	M	V	L	R	F	G	G	A	F	C	G	A	I	L	A	L	L	F	T	L	L	V	M
Secondary structure
SS confidence
Disorder																													?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		P	W	L	D	N	I	V	E	L	L	F	V	L	A	P	I	F	L	L	G	A	W	I	A	T	S	S	E	R	S	S	Y	I	G	T	Q	M	V	V	T	F	A	L	A	T	L	E	N	V	F	G	P	V	Y	D	L	V	E	I	R
Secondary structure
SS confidence
Disorder																									?	?	?	?																			?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		D	R	A	L	G	I	I	I	G	T	V	V	S	A	V	I	Y	T	F	V	W	P	E	S	E	A	R	T	L	P	Q	K	L	A	G	T	L	G	M	L	S	K	V	M	R	I	P	R	Q	Q	E	V	T	A	L	R	T	Y	L	Q
Secondary structure
SS confidence
Disorder																																																			?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		I	R	I	G	L	H	A	A	F	N	A	C	E	E	M	C	Q	R	V	A	L	E	R	Q	L	D	S	E	E	R	A	L	L	I	E	R	S	Q	T	V	I	R	Q	G	R	D	L	L	H	A	W	D	A	T	W	N	S	A	Q	A
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?	?	?	?																														?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		L	D	N	A	L	Q	P	D	R	A	G	Q	F	A	D	A	L	E	K	Y	A	A	G	L	A	T	A	L	S	R	S	P	Q	I	T	L	E	E	T	P	A	S	Q	A	I	L	P	T	L	L	K	Q	E	Q	H	V	C	Q	L	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																				?	?	?	?		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.
Sequence		A	R	L	P	D	W	T	A	P	A	L	T	P	A	T	E	Q	A	Q	G	A	T	Q
Secondary structure
SS confidence
Disorder									?				?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2r6g chain F domain 1 Region: 404 - 466 Aligned: 63 Modelled: 63 Confidence: 32.8% Identity: 10% Fold: MalF N-terminal region-like Superfamily: MalF N-terminal region-like Family: MalF N-terminal region-like Phyre2 PDB 1oy8 chain A Region: 345 - 502 Aligned: 143 Modelled: 143 Confidence: 21.7% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:acriflavine resistance protein b; PDBTitle: structural basis of multiple drug binding capacity of the acrb2 multidrug efflux pump Phyre2 PDB 2w2e chain A Region: 323 - 524 Aligned: 197 Modelled: 202 Confidence: 21.0% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:aquaporin; PDBTitle: 1.15 angstrom crystal structure of p.pastoris aquaporin,2 aqy1, in a closed conformation at ph 3.5 Phyre2 PDB 1kpl chain A Region: 357 - 519 Aligned: 123 Modelled: 131 Confidence: 20.0% Identity: 12% Fold: Clc chloride channel Superfamily: Clc chloride channel Family: Clc chloride channel Phyre2 PDB 3nd0 chain A Region: 357 - 513 Aligned: 117 Modelled: 125 Confidence: 19.4% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:sll0855 protein; PDBTitle: x-ray crystal structure of a slow cyanobacterial cl-/h+ antiporter Phyre2 PDB 2ht2 chain B Region: 358 - 515 Aligned: 118 Modelled: 139 Confidence: 16.1% Identity: 16% PDB header:membrane protein Chain: B: PDB Molecule:h(+)/cl(-) exchange transporter clca; PDBTitle: structure of the escherichia coli clc chloride channel2 y445h mutant and fab complex Phyre2 PDB 1st6 chain A domain 4 Region: 182 - 289 Aligned: 104 Modelled: 108 Confidence: 13.8% Identity: 13% Fold: Four-helical up-and-down bundle Superfamily: alpha-catenin/vinculin-like Family: alpha-catenin/vinculin Phyre2 PDB 1ots chain A Region: 351 - 519 Aligned: 129 Modelled: 150 Confidence: 13.0% Identity: 17% Fold: Clc chloride channel Superfamily: Clc chloride channel Family: Clc chloride channel Phyre2 PDB 1szi chain A Region: 548 - 651 Aligned: 102 Modelled: 104 Confidence: 12.9% Identity: 12% Fold: Four-helical up-and-down bundle Superfamily: Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain Family: Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain Phyre2 PDB 1no1 chain C Region: 17 - 30 Aligned: 14 Modelled: 14 Confidence: 11.3% Identity: 36% PDB header:replication Chain: C: PDB Molecule:replisome organizer; PDBTitle: structure of truncated variant of b.subtilis spp1 phage g39p helicase2 loader/inhibitor protein Phyre2 PDB 1no1 chain A Region: 17 - 30 Aligned: 14 Modelled: 14 Confidence: 11.3% Identity: 36% Fold: Replisome organizer (g39p helicase loader/inhibitor protein) Superfamily: Replisome organizer (g39p helicase loader/inhibitor protein) Family: Replisome organizer (g39p helicase loader/inhibitor protein) Phyre2 PDB 2ksf chain A Region: 403 - 499 Aligned: 96 Modelled: 97 Confidence: 11.2% Identity: 8% PDB header:transferase Chain: A: PDB Molecule:sensor protein kdpd; PDBTitle: backbone structure of the membrane domain of e. coli2 histidine kinase receptor kdpd, center for structures of3 membrane proteins (csmp) target 4312c Phyre2 PDB 1bhb chain A Region: 11 - 51 Aligned: 41 Modelled: 41 Confidence: 9.9% Identity: 12% PDB header:photoreceptor Chain: A: PDB Molecule:bacteriorhodopsin; PDBTitle: three-dimensional structure of (1-71) bacterioopsin2 solubilized in methanol-chloroform and sds micelles3 determined by 15n-1h heteronuclear nmr spectroscopy Phyre2 PDB 1b9u chain A Region: 485 - 500 Aligned: 16 Modelled: 16 Confidence: 9.5% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:protein (atp synthase); PDBTitle: membrane domain of the subunit b of the e.coli atp synthase Phyre2 PDB 3su8 chain X Region: 5 - 36 Aligned: 31 Modelled: 32 Confidence: 8.5% Identity: 13% PDB header:apoptosis/signaling protein Chain: X: PDB Molecule:plexin-b1; PDBTitle: crystal structure of a truncated intracellular domain of plexin-b1 in2 complex with rac1 Phyre2 PDB 2d57 chain A Region: 354 - 502 Aligned: 147 Modelled: 149 Confidence: 8.4% Identity: 18% PDB header:transport protein Chain: A: PDB Molecule:aquaporin-4; PDBTitle: double layered 2d crystal structure of aquaporin-4 (aqp4m23) at 3.2 a2 resolution by electron crystallography Phyre2 PDB 3g9d chain B Region: 398 - 412 Aligned: 15 Modelled: 15 Confidence: 8.3% Identity: 27% PDB header:hydrolase Chain: B: PDB Molecule:dinitrogenase reductase activacting PDBTitle: crystal structure glycohydrolase Phyre2 PDB 1st6 chain A domain 3 Region: 183 - 290 Aligned: 105 Modelled: 108 Confidence: 8.3% Identity: 10% Fold: Four-helical up-and-down bundle Superfamily: alpha-catenin/vinculin-like Family: alpha-catenin/vinculin Phyre2 PDB 2b5f chain D Region: 354 - 500 Aligned: 145 Modelled: 147 Confidence: 8.3% Identity: 15% PDB header:transport protein,membrane protein Chain: D: PDB Molecule:aquaporin; PDBTitle: crystal structure of the spinach aquaporin sopip2;1 in an2 open conformation to 3.9 resolution Phyre2 PDB 2woc chain A Region: 398 - 412 Aligned: 15 Modelled: 15 Confidence: 8.0% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:adp-ribosyl-[dinitrogen reductase] glycohydrolase; PDBTitle: crystal structure of the dinitrogenase reductase-activating2 glycohydrolase (drag) from rhodospirillum rubrum Phyre2 1 d2r6gf1 2 c1oy8A_ 3 c2w2eA_ 4 d1kpla_ 5 c3nd0A_ 6 c2ht2B_ 7 d1st6a4 8 d1otsa_ 9 d1szia_ 10 c1no1C_ 11 d1no1a_ 12 c2ksfA_ 13 c1bhbA_ 14 c1b9uA_ 15 c3su8X_ 16 c2d57A_ 17 c3g9dB_ 18 d1st6a3 19 c2b5fD_ 20 c2wocA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50