PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c2f2bA_

Fold library id	PDB Header	Molecule	Title
c2f2bA_	PDB header: membrane protein	Chain: A: PDB Molecule: aquaporin aqpm;	PDBTitle: crystal structure of integral membrane protein aquaporin2 aqpm at 1.68a resolution

Links to external resources
Added to library: Tue Mar 16 12:54:54 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence M V S L T K R C I A E F I G T F I L V F F G A G S A A V T L M I A S G G T S P N P F N I G I G L L G G L G D W V A I G L A F G F A I A A S I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
S S T T
S T T T T T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence Y A L G N I S G C H I N P A V T I G L W S V K K F P G R E V V P Y I I A Q L L G A A F G S F I F L Q C A G I G A A T V G G L G A T A P F P G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T T
S T T S S
G G G
T T T G G G
T T

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence I S Y W Q A M L A E V V G T F L L M I T I M G I A V D E R A P K G F A G I I I G L T V A G I I T T L G N I S G S S L N P A R T F G P Y L N D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S T T S
T T

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . .

Sequence M I F A G T D L W N Y Y S I Y V I G P I V G A V L A A L T Y Q Y L T S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
G G G T T T

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	M	V	S	L	T	K	R	C	I	A	E	F	I	G	T	F	I	L	V	F	F	G	A	G	S	A	A	V	T	L	M	I	A	S	G	G	T	S	P	N	P	F	N	I	G	I	G	L	L	G	G	L	G	D	W	V	A	I	G	L	A	F	G	F	A	I	A	A	S	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																																		T	T				S	S	T	T			S	T	T	T	T	T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	Y	A	L	G	N	I	S	G	C	H	I	N	P	A	V	T	I	G	L	W	S	V	K	K	F	P	G	R	E	V	V	P	Y	I	I	A	Q	L	L	G	A	A	F	G	S	F	I	F	L	Q	C	A	G	I	G	A	A	T	V	G	G	L	G	A	T	A	P	F	P	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				T	T	T	T					S										T	T	S	S		G	G	G																									T					T	T	G	G	G						T	T
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	I	S	Y	W	Q	A	M	L	A	E	V	V	G	T	F	L	L	M	I	T	I	M	G	I	A	V	D	E	R	A	P	K	G	F	A	G	I	I	I	G	L	T	V	A	G	I	I	T	T	L	G	N	I	S	G	S	S	L	N	P	A	R	T	F	G	P	Y	L	N	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																									T	T	S	T	T	S		T	T
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.
Sequence	M	I	F	A	G	T	D	L	W	N	Y	Y	S	I	Y	V	I	G	P	I	V	G	A	V	L	A	A	L	T	Y	Q	Y	L	T	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)									G	G	G	T	T																					T