PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c2w2eA_

Fold library id	PDB Header	Molecule	Title
c2w2eA_	PDB header: membrane protein	Chain: A: PDB Molecule: aquaporin;	PDBTitle: 1.15 angstrom crystal structure of p.pastoris aquaporin,2 aqy1, in a closed conformation at ph 3.5

Links to external resources
Added to library: Sat Aug 28 23:58:05 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence G Q A E I K P E D A P Y I T N A Y K P A Y A R W G F G S D S V R N H F I A M S G E F V G T F L F L W S A F V I A Q I A N Q A P E T P D G G S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
G G G T S
G G G G
T T T T S T T S
G G G

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence N P A Q L I M I S F G F G F G V M V G V F I T Y R V S G G N L N P A V T L A L V L A R A I P P F R G I L M A F T Q I V A G M A A A G A A S A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T T
S T T S S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence M T P G E I A F A N A L G G G A S R T R G L F L E A F G T A I L C L T V L M L A V E K H R A T W F A P F V I G I A L L I A H L I C I Y Y T G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S S
S
T T
T T S
S T T G G G

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . .

Sequence A G L N P A R S F G P A V A A R S F P N Y H W I Y W L G P I L G A F L A Y S I W Q M W K W L N Y Q T T N P

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S T
T T T T T T T T
S

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

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Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	G	Q	A	E	I	K	P	E	D	A	P	Y	I	T	N	A	Y	K	P	A	Y	A	R	W	G	F	G	S	D	S	V	R	N	H	F	I	A	M	S	G	E	F	V	G	T	F	L	F	L	W	S	A	F	V	I	A	Q	I	A	N	Q	A	P	E	T	P	D	G	G	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							G	G	G	T					S					G	G	G	G			T	T	T	T	S																														T	T	S				G	G	G
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	N	P	A	Q	L	I	M	I	S	F	G	F	G	F	G	V	M	V	G	V	F	I	T	Y	R	V	S	G	G	N	L	N	P	A	V	T	L	A	L	V	L	A	R	A	I	P	P	F	R	G	I	L	M	A	F	T	Q	I	V	A	G	M	A	A	A	G	A	A	S	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																								T	T	T	T					S										T	T	S	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	M	T	P	G	E	I	A	F	A	N	A	L	G	G	G	A	S	R	T	R	G	L	F	L	E	A	F	G	T	A	I	L	C	L	T	V	L	M	L	A	V	E	K	H	R	A	T	W	F	A	P	F	V	I	G	I	A	L	L	I	A	H	L	I	C	I	Y	Y	T	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		S		S	S				S					T	T																									T	T	S		S	T	T	G	G	G
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.
Sequence	A	G	L	N	P	A	R	S	F	G	P	A	V	A	A	R	S	F	P	N	Y	H	W	I	Y	W	L	G	P	I	L	G	A	F	L	A	Y	S	I	W	Q	M	W	K	W	L	N	Y	Q	T	T	N	P
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				S												T				T	T	T	T																							T	T	T	T		S