PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c2d57A_

Fold library id	PDB Header	Molecule	Title
c2d57A_	PDB header: transport protein	Chain: A: PDB Molecule: aquaporin-4;	PDBTitle: double layered 2d crystal structure of aquaporin-42 (aqp4m23) at 3.2 a resolution by electron crystallography

Links to external resources
Added to library: Tue Mar 16 13:53:25 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence T Q A F W K A V T A E F L A M L I F V L L S V G S T I N W G G S E N P L P V D M V L I S L C F G L S I A T M V Q C F G H I S G G H I N P A V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T S S S S
T
S
S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence T V A M V C T R K I S I A K S V F Y I T A Q C L G A I I G A G I L Y L V T P P S V V G G L G V T T V H G N L T A G H G L L V E L I I T F Q L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S
T T T G G G
S S
S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence V F T I F A S C D S K R T D V T G S V A L A I G F S V A I G H L F A I N Y T G A S M N P A R S F G P A V I M G N W E N H W I Y W V G P I I G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S S S
S
S
T T T

. . . . . . . . . 220 . . . .

Sequence A V L A G A L Y E Y V F C P

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	T	Q	A	F	W	K	A	V	T	A	E	F	L	A	M	L	I	F	V	L	L	S	V	G	S	T	I	N	W	G	G	S	E	N	P	L	P	V	D	M	V	L	I	S	L	C	F	G	L	S	I	A	T	M	V	Q	C	F	G	H	I	S	G	G	H	I	N	P	A	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T																												S	S	S	S				T																											S			S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	T	V	A	M	V	C	T	R	K	I	S	I	A	K	S	V	F	Y	I	T	A	Q	C	L	G	A	I	I	G	A	G	I	L	Y	L	V	T	P	P	S	V	V	G	G	L	G	V	T	T	V	H	G	N	L	T	A	G	H	G	L	L	V	E	L	I	I	T	F	Q	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								S		S																												T	T	T	G	G	G		S	S						S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	V	F	T	I	F	A	S	C	D	S	K	R	T	D	V	T	G	S	V	A	L	A	I	G	F	S	V	A	I	G	H	L	F	A	I	N	Y	T	G	A	S	M	N	P	A	R	S	F	G	P	A	V	I	M	G	N	W	E	N	H	W	I	Y	W	V	G	P	I	I	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)									S	S	S		S				S																																									T	T	T
	.	.	.	.	.	.	.	.	.	220	.	.	.	.
Sequence	A	V	L	A	G	A	L	Y	E	Y	V	F	C	P
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)										T	T	T