Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	Q	G	A	G	W	L	L	L	L	A	P	F	F	F	F	T	Y	G	S	L	N	Q	F	T	A	V	Q	D	L	N	S	H	D	I	P	S	Q	V	F	G	W	E	T	A	I	P	F	L	P	W	T	I	V	P	Y	W	S	L
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	L	L	Y	G	F	S	L	F	V	C	S	T	T	F	E	Q	R	R	L	V	H	R	L	I	L	A	T	V	M	A	C	C	G	F	L	L	Y	P	L	K	F	S	F	I	R	P	E	V	S	G	V	T	G	W	L	F	S	Q	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	L	F	D	L	P	Y	N	Q	S	P	S	L	H	I	I	L	C	W	L	L	W	R	H	F	R	Q	H	L	A	E	R	W	R	K	V	C	G	G	W	F	L	L	I	A	I	S	T	L	T	T	W	Q	H	H	F	I	D	V	I
Secondary structure
SS confidence
Disorder																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	G	L	A	V	G	M	L	I	D	W	M	V	P	V	D	R	R	W	N	Y	Q	K	P	D	Q	R	R	I	K	I	A	L	P	Y	V	V	G	A	G	S	C	I	V	L	M	E	L	M	M	M	I	Q	L	W	W	S	V	W	L
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?	?			?	?	?																								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		C	W	P	V	L	S	L	L	I	I	G	R	G	Y	G	G	L	G	A	I	T	T	G	K	D	S	Q	G	K	L	P	P	A	V	Y	W	L	T	L	P	C	R	I	G	M	W	L	S	M	R	W	F	C	R	R	L	E	P	V	S
Secondary structure
SS confidence
Disorder																						?	?		?	?	?	?																								?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		K	M	T	A	G	V	Y	L	G	A	F	P	R	H	I	P	A	Q	N	A	V	L	D	V	T	F	E	F	P	R	G	R	A	T	K	D	R	L	Y	F	C	V	P	M	L	D	L	V	V	P	E	E	G	E	L	R	Q	A	V	A
Secondary structure
SS confidence
Disorder														?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		M	L	E	T	L	R	E	E	Q	G	S	V	L	V	H	C	A	L	G	L	S	R	S	A	L	V	V	A	A	W	L	L	C	Y	G	H	C	K	T	V	N	E	A	I	S	Y	I	R	A	R	R	P	Q	I	V	L	T	D	E	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430
Sequence		K	A	M	L	R	L	W	E	N	R
Secondary structure
SS confidence
Disorder										?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2j17 chain A Region: 293 - 430 Aligned: 136 Modelled: 138 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase yil113w; PDBTitle: ptyr bound form of sdp-1 Phyre2 PDB 2esb chain A Region: 299 - 430 Aligned: 130 Modelled: 132 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase 18; PDBTitle: crystal structure of human dusp18 Phyre2 PDB 2oud chain A Region: 298 - 430 Aligned: 132 Modelled: 133 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase 10; PDBTitle: crystal structure of the catalytic domain of human mkp5 Phyre2 PDB 2p4d chain A Region: 297 - 428 Aligned: 131 Modelled: 129 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase; PDBTitle: structure-assisted discovery of variola major h12 phosphatase inhibitors Phyre2 PDB 2hcm chain A Region: 295 - 430 Aligned: 134 Modelled: 136 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase; PDBTitle: crystal structure of mouse putative dual specificity phosphatase2 complexed with zinc tungstate, new york structural genomics3 consortium Phyre2 PDB 3rgq chain A Region: 298 - 430 Aligned: 132 Modelled: 133 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:protein-tyrosine phosphatase mitochondrial 1; PDBTitle: crystal structure of ptpmt1 in complex with pi(5)p Phyre2 PDB 2wgp chain A Region: 299 - 429 Aligned: 129 Modelled: 131 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase 14; PDBTitle: crystal structure of human dual specificity phosphatase 14 Phyre2 PDB 2nt2 chain C Region: 298 - 430 Aligned: 131 Modelled: 133 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: C: PDB Molecule:protein phosphatase slingshot homolog 2; PDBTitle: crystal structure of slingshot phosphatase 2 Phyre2 PDB 1zzw chain A Region: 297 - 430 Aligned: 133 Modelled: 134 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase 10; PDBTitle: crystal structure of catalytic domain of human map kinase2 phosphatase 5 Phyre2 PDB 1yz4 chain A Region: 293 - 430 Aligned: 135 Modelled: 138 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:dual specificity phosphatase-like 15 isoform a; PDBTitle: crystal structure of dusp15 Phyre2 PDB 2gwo chain C Region: 284 - 430 Aligned: 145 Modelled: 147 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: C: PDB Molecule:dual specificity protein phosphatase 13; PDBTitle: crystal structure of tmdp Phyre2 PDB 2r0b chain A Region: 296 - 429 Aligned: 133 Modelled: 134 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:serine/threonine/tyrosine-interacting protein; PDBTitle: crystal structure of human tyrosine phosphatase-like2 serine/threonine/tyrosine-interacting protein Phyre2 PDB 1mkp chain A Region: 299 - 430 Aligned: 131 Modelled: 132 Confidence: 100.0% Identity: 21% Fold: (Phosphotyrosine protein) phosphatases II Superfamily: (Phosphotyrosine protein) phosphatases II Family: Dual specificity phosphatase-like Phyre2 PDB 2g6z chain B Region: 299 - 430 Aligned: 130 Modelled: 132 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:dual specificity protein phosphatase 5; PDBTitle: crystal structure of human dusp5 Phyre2 PDB 1wrm chain A Region: 299 - 429 Aligned: 128 Modelled: 131 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:dual specificity phosphatase 22; PDBTitle: crystal structure of jsp-1 Phyre2 PDB 3emu chain A Region: 299 - 430 Aligned: 123 Modelled: 132 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:leucine rich repeat and phosphatase domain PDBTitle: crystal structure of a leucine rich repeat and phosphatase2 domain containing protein from entamoeba histolytica Phyre2 PDB 2img chain A Region: 297 - 430 Aligned: 133 Modelled: 134 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase 23; PDBTitle: crystal structure of dual specificity protein phosphatase2 23 from homo sapiens in complex with ligand malate ion Phyre2 PDB 1m3g chain A Region: 299 - 430 Aligned: 130 Modelled: 132 Confidence: 100.0% Identity: 23% Fold: (Phosphotyrosine protein) phosphatases II Superfamily: (Phosphotyrosine protein) phosphatases II Family: Dual specificity phosphatase-like Phyre2 PDB 1vhr chain A Region: 298 - 430 Aligned: 131 Modelled: 133 Confidence: 100.0% Identity: 26% Fold: (Phosphotyrosine protein) phosphatases II Superfamily: (Phosphotyrosine protein) phosphatases II Family: Dual specificity phosphatase-like Phyre2 PDB 2y96 chain A Region: 280 - 430 Aligned: 149 Modelled: 151 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:dual specificity phosphatase dupd1; PDBTitle: structure of human dual-specificity phosphatase 27 Phyre2 PDB 2akc chain C Region: 73 - 190 Aligned: 117 Modelled: 117 Confidence: 99.2% Identity: 17% PDB header:hydrolase Chain: C: PDB Molecule:class a nonspecific acid phosphatase phon; PDBTitle: crystal structure of tungstate complex of the phon protein2 from s. typhimurium Phyre2 PDB 1d2t chain A Region: 124 - 190 Aligned: 66 Modelled: 66 Confidence: 99.0% Identity: 17% Fold: Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily: Acid phosphatase/Vanadium-dependent haloperoxidase Family: Type 2 phosphatidic acid phosphatase, PAP2 Phyre2 1 c2j17A_ 2 c2esbA_ 3 c2oudA_ 4 c2p4dA_ 5 c2hcmA_ 6 c3rgqA_ 7 c2wgpA_ 8 c2nt2C_ 9 c1zzwA_ 10 c1yz4A_ 11 c2gwoC_ 12 c2r0bA_ 13 d1mkpa_ 14 c2g6zB_ 15 c1wrmA_ 16 c3emuA_ 17 c2imgA_ 18 d1m3ga_ 19 d1vhra_ 20 c2y96A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 c2akcC_ 45 46 47 48 49 50 51 52 53 d1d2ta_ 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2j17A_ 100.0 19 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase yil113w; PDBTitle: ptyr bound form of sdp-1 2 c2esbA_ 100.0 24 PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase 18; PDBTitle: crystal structure of human dusp18 3 c2oudA_ 100.0 22 PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase 10; PDBTitle: crystal structure of the catalytic domain of human mkp5 4 c2p4dA_ 100.0 21 PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase; PDBTitle: structure-assisted discovery of variola major h12 phosphatase inhibitors 5 c2hcmA_ 100.0 22 PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase; PDBTitle: crystal structure of mouse putative dual specificity phosphatase2 complexed with zinc tungstate, new york structural genomics3 consortium 6 c3rgqA_ 100.0 23 PDB header:hydrolase Chain: A: PDB Molecule:protein-tyrosine phosphatase mitochondrial 1; PDBTitle: crystal structure of ptpmt1 in complex with pi(5)p 7 c2wgpA_ 100.0 25 PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase 14; PDBTitle: crystal structure of human dual specificity phosphatase 14 8 c2nt2C_ 100.0 18 PDB header:hydrolase Chain: C: PDB Molecule:protein phosphatase slingshot homolog 2; PDBTitle: crystal structure of slingshot phosphatase 2 9 c1zzwA_ 100.0 22 PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase 10; PDBTitle: crystal structure of catalytic domain of human map kinase2 phosphatase 5 10 c1yz4A_ 100.0 19 PDB header:hydrolase Chain: A: PDB Molecule:dual specificity phosphatase-like 15 isoform a; PDBTitle: crystal structure of dusp15 11 c2gwoC_ 100.0 23 PDB header:hydrolase Chain: C: PDB Molecule:dual specificity protein phosphatase 13; PDBTitle: crystal structure of tmdp 12 c2r0bA_ 100.0 21 PDB header:hydrolase Chain: A: PDB Molecule:serine/threonine/tyrosine-interacting protein; PDBTitle: crystal structure of human tyrosine phosphatase-like2 serine/threonine/tyrosine-interacting protein 13 d1mkpa_ 100.0 21 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 14 c2g6zB_ 100.0 24 PDB header:hydrolase Chain: B: PDB Molecule:dual specificity protein phosphatase 5; PDBTitle: crystal structure of human dusp5 15 c1wrmA_ 100.0 23 PDB header:hydrolase Chain: A: PDB Molecule:dual specificity phosphatase 22; PDBTitle: crystal structure of jsp-1 16 c3emuA_ 100.0 16 PDB header:hydrolase Chain: A: PDB Molecule:leucine rich repeat and phosphatase domain PDBTitle: crystal structure of a leucine rich repeat and phosphatase2 domain containing protein from entamoeba histolytica 17 c2imgA_ 100.0 23 PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase 23; PDBTitle: crystal structure of dual specificity protein phosphatase2 23 from homo sapiens in complex with ligand malate ion 18 d1m3ga_ 100.0 23 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 19 d1vhra_ 100.0 26 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 20 c2y96A_ 100.0 21 PDB header:hydrolase Chain: A: PDB Molecule:dual specificity phosphatase dupd1; PDBTitle: structure of human dual-specificity phosphatase 27 21 c3nmeA_ not modelled 100.0 12 PDB header:hydrolase Chain: A: PDB Molecule:sex4 glucan phosphatase; PDBTitle: structure of a plant phosphatase 22 c2e0tA_ not modelled 100.0 28 PDB header:hydrolase Chain: A: PDB Molecule:dual specificity phosphatase 26; PDBTitle: crystal structure of catalytic domain of dual specificity phosphatase2 26, ms0830 from homo sapiens 23 d1ohea2 not modelled 99.9 15 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 24 c1fpzF_ not modelled 99.9 19 PDB header:hydrolase Chain: F: PDB Molecule:cyclin-dependent kinase inhibitor 3; PDBTitle: crystal structure analysis of kinase associated phosphatase2 (kap) with a substitution of the catalytic site cysteine3 (cys140) to a serine 25 c2i6oA_ not modelled 99.9 24 PDB header:hydrolase Chain: A: PDB Molecule:sulfolobus solfataricus protein tyrosine PDBTitle: crystal structure of the complex of the archaeal sulfolobus2 ptp-fold phosphatase with phosphopeptides n-g-(p)y-k-n 26 c3s4oB_ not modelled 99.9 21 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:protein tyrosine phosphatase-like protein; PDBTitle: protein tyrosine phosphatase (putative) from leishmania major 27 d1fpza_ not modelled 99.9 19 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 28 c1oheA_ not modelled 99.9 15 PDB header:hydrolase Chain: A: PDB Molecule:cdc14b2 phosphatase; PDBTitle: structure of cdc14b phosphatase with a peptide ligand 29 c2c46B_ not modelled 99.9 15 PDB header:transferase Chain: B: PDB Molecule:mrna capping enzyme; PDBTitle: crystal structure of the human rna guanylyltransferase and2 5'-phosphatase 30 d1d5ra2 not modelled 99.9 17 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 31 c1yn9B_ not modelled 99.9 20 PDB header:hydrolase Chain: B: PDB Molecule:polynucleotide 5'-phosphatase; PDBTitle: crystal structure of baculovirus rna 5'-phosphatase2 complexed with phosphate 32 c3awfC_ not modelled 99.9 22 PDB header:hydrolase, membrane protein Chain: C: PDB Molecule:voltage-sensor containing phosphatase; PDBTitle: crystal structure of pten-like domain of ci-vsp (236-576) 33 d1i9sa_ not modelled 99.9 15 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 34 d1rxda_ not modelled 99.8 17 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 35 d1v3aa_ not modelled 99.8 17 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 36 c3gxgA_ not modelled 99.8 13 PDB header:hydrolase Chain: A: PDB Molecule:putative phosphatase (duf442); PDBTitle: crystal structure of putative phosphatase (duf442) (yp_001181608.1)2 from shewanella putrefaciens cn-32 at 1.60 a resolution 37 c1d5rA_ not modelled 99.8 17 PDB header:hydrolase Chain: A: PDB Molecule:phosphoinositide phosphotase pten; PDBTitle: crystal structure of the pten tumor suppressor 38 c3n0aA_ not modelled 99.8 17 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase auxilin; PDBTitle: crystal structure of auxilin (40-400) 39 d1xria_ not modelled 99.8 15 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 40 c3rz2B_ not modelled 99.8 19 PDB header:hydrolase Chain: B: PDB Molecule:protein tyrosine phosphatase type iva 1; PDBTitle: crystal of prl-1 complexed with peptide 41 c2f46A_ not modelled 99.7 13 PDB header:hydrolase Chain: A: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of a putative phosphatase (nma1982) from neisseria2 meningitidis z2491 at 1.41 a resolution 42 c1g4wR_ not modelled 99.4 14 PDB header:signaling protein Chain: R: PDB Molecule:protein tyrosine phosphatase sptp; PDBTitle: crystal structure of the salmonella tyrosine phosphatase2 and gtpase activating protein sptp 43 d1g4us2 not modelled 99.3 13 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 44 c2akcC_ 99.2 17 PDB header:hydrolase Chain: C: PDB Molecule:class a nonspecific acid phosphatase phon; PDBTitle: crystal structure of tungstate complex of the phon protein2 from s. typhimurium 45 c1u24A_ not modelled 99.1 17 PDB header:hydrolase Chain: A: PDB Molecule:myo-inositol hexaphosphate phosphohydrolase; PDBTitle: crystal structure of selenomonas ruminantium phytase 46 d1lyva_ not modelled 99.1 16 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 47 c2b49A_ not modelled 99.1 24 PDB header:hydrolase Chain: A: PDB Molecule:protein tyrosine phosphatase, non-receptor type 3; PDBTitle: crystal structure of the catalytic domain of protein tyrosine2 phosphatase, non-receptor type 3 48 d1ywfa1 not modelled 99.1 23 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Mycobacterial PtpB-like 49 d1lara1 not modelled 99.1 17 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 50 c2shpA_ not modelled 99.0 22 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 51 d1larb1 not modelled 99.0 16 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 52 c2b3oA_ not modelled 99.0 20 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 53 d1d2ta_ 99.0 17 Fold:Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily:Acid phosphatase/Vanadium-dependent haloperoxidase Family:Type 2 phosphatidic acid phosphatase, PAP2 54 c2pa5A_ not modelled 99.0 19 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 9; PDBTitle: crystal structure of human protein tyrosine phosphatase ptpn9 55 c2qepA_ not modelled 99.0 20 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase n2; PDBTitle: crystal structure of the d1 domain of ptprn2 (ia2beta) 56 c3ps5A_ not modelled 99.0 19 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 57 d1wcha_ not modelled 99.0 16 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 58 c2bzlA_ not modelled 99.0 17 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of the human protein tyrosine phosphatase2 n14 at 1.65 a resolution 59 c1larB_ not modelled 99.0 16 PDB header:hydrolase Chain: B: PDB Molecule:protein (lar); PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 lar 60 c3s3fA_ not modelled 99.0 20 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:tyrosine-protein phosphatase 10d; PDBTitle: crystal structure of the catalytic domain of ptp10d from drosophila2 melanogaster with a small molecule inhibitor vanadate 61 c2nz6A_ not modelled 99.0 21 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase eta; PDBTitle: crystal structure of the ptprj inactivating mutant c1239s 62 c2i75A_ not modelled 98.9 17 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 4; PDBTitle: crystal structure of human protein tyrosine phosphatase n4 (ptpn4) 63 c2bijA_ not modelled 98.9 19 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type 5; PDBTitle: crystal structure of the human protein tyrosine phosphatase2 ptpn5 (step, striatum enriched enriched phosphatase) 64 c2jjdA_ not modelled 98.9 20 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase epsilon; PDBTitle: protein tyrosine phosphatase, receptor type, e isoform 65 c2g59B_ not modelled 98.9 20 PDB header:hydrolase Chain: B: PDB Molecule:receptor-type tyrosine-protein phosphatase o; PDBTitle: crystal structure of the catalytic domain of protein2 tyrosine phosphatase from homo sapiens 66 c3m4uB_ not modelled 98.9 20 PDB header:hydrolase Chain: B: PDB Molecule:tyrosine specific protein phosphatase, putative; PDBTitle: crystal structure of trypanosoma brucei protein tyrosine phosphatase2 tbptp1 67 d1rpma_ not modelled 98.9 20 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 68 d2pt0a1 not modelled 98.9 12 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Myo-inositol hexaphosphate phosphohydrolase (phytase) PhyA 69 c2oc3A_ not modelled 98.9 19 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type PDBTitle: crystal structure of the catalytic domain of human protein2 tyrosine phosphatase non-receptor type 18 70 d1lara2 not modelled 98.9 19 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 71 d1jlna_ not modelled 98.9 25 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 72 c2qdmA_ not modelled 98.9 20 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 7; PDBTitle: crystal structure of the heptp catalytic domain c270s/d236a/q314a2 mutant 73 c2qcjB_ not modelled 98.9 23 PDB header:hydrolase Chain: B: PDB Molecule:tyrosine-protein phosphatase non-receptor type PDBTitle: native structure of lyp 74 c3jrlA_ not modelled 98.9 19 PDB header:hydrolase Chain: A: PDB Molecule:oncogenic tyrosine phosphatase shp2; PDBTitle: crystal structure of the oncogenic tyrosine phosphatase shp2 complexed2 with a salicylic acid-based small molecule inhibitor 75 c1yguA_ not modelled 98.9 14 PDB header:hydrolase Chain: A: PDB Molecule:leukocyte common antigen; PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 cd45 with a ptyr peptide 76 c2h04A_ not modelled 98.9 22 PDB header:hydrolase Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, b,; PDBTitle: structural studies of protein tyrosine phosphatase beta2 catalytic domain in complex with inhibitors 77 d2shpa1 not modelled 98.9 22 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 78 c1l8kA_ not modelled 98.9 17 PDB header:hydrolase Chain: A: PDB Molecule:t-cell protein-tyrosine phosphatase; PDBTitle: t cell protein-tyrosine phosphatase structure 79 d1l8ka_ not modelled 98.9 17 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 80 c3i36A_ not modelled 98.9 21 PDB header:hydrolase Chain: A: PDB Molecule:vascular protein tyrosine phosphatase 1; PDBTitle: crystal structure of rat protein tyrosine phosphatase eta catalytic2 domain 81 c2c7sA_ not modelled 98.9 18 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase kappa; PDBTitle: crystal structure of human protein tyrosine phosphatase2 kappa at 1.95a resolution 82 d1yfoa_ not modelled 98.9 24 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 83 c2nlkA_ not modelled 98.8 17 PDB header:hydrolase Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, g variant PDBTitle: crystal structure of d1 and d2 catalytic domains of human protein2 tyrosine phosphatase gamma (d1+d2 ptprg) 84 c2vexA_ not modelled 98.8 21 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 1; PDBTitle: crystal strucutre of protein tyrosine phosphatase 1b in2 complex with an isothiazolidinone-containing inhibitor 85 c3f41B_ not modelled 98.8 11 PDB header:hydrolase Chain: B: PDB Molecule:phytase; PDBTitle: structure of the tandemly repeated protein tyrosine2 phosphatase like phytase from mitsuokella multacida 86 d1fpra_ not modelled 98.8 20 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 87 d2f71a1 not modelled 98.8 22 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 88 c2hy3A_ not modelled 98.8 25 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase gamma; PDBTitle: crystal structure of the human tyrosine receptor phosphate gamma in2 complex with vanadate 89 d1p15a_ not modelled 98.7 18 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 90 c2oz5A_ not modelled 98.5 23 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:phosphotyrosine protein phosphatase ptpb; PDBTitle: crystal structure of mycobacterium tuberculosis protein tyrosine2 phosphatase ptpb in complex with the specific inhibitor omts 91 d1ohea1 not modelled 98.1 14 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 92 d1zsqa2 not modelled 93.3 26 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Myotubularin-like phosphatases 93 d1qi9a_ not modelled 93.1 23 Fold:Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily:Acid phosphatase/Vanadium-dependent haloperoxidase Family:Haloperoxidase (bromoperoxidase) 94 c1lw3A_ not modelled 93.0 26 PDB header:hydrolase Chain: A: PDB Molecule:myotubularin-related protein 2; PDBTitle: crystal structure of myotubularin-related protein 22 complexed with phosphate 95 c1zsqA_ not modelled 92.5 26 PDB header:hydrolase Chain: A: PDB Molecule:myotubularin-related protein 2; PDBTitle: crystal structure of mtmr2 in complex with2 phosphatidylinositol 3-phosphate 96 c2yf0A_ not modelled 91.8 35 PDB header:hydrolase Chain: A: PDB Molecule:myotubularin-related protein 6; PDBTitle: human myotubularin related protein 6 (mtmr6) 97 c2j6pF_ not modelled 87.6 19 PDB header:oxidoreductase Chain: F: PDB Molecule:sb(v)-as(v) reductase; PDBTitle: structure of as-sb reductase from leishmania major 98 d1em8a_ not modelled 83.8 10 Fold:DNA polymerase III chi subunit Superfamily:DNA polymerase III chi subunit Family:DNA polymerase III chi subunit 99 c3olhA_ not modelled 78.0 12 PDB header:transferase Chain: A: PDB Molecule:3-mercaptopyruvate sulfurtransferase; PDBTitle: human 3-mercaptopyruvate sulfurtransferase 100 d1vnsa_ not modelled 76.5 22 Fold:Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily:Acid phosphatase/Vanadium-dependent haloperoxidase Family:Chloroperoxidase 101 c3i2vA_ not modelled 73.8 17 PDB header:transferase Chain: A: PDB Molecule:adenylyltransferase and sulfurtransferase mocs3; PDBTitle: crystal structure of human mocs3 rhodanese-like domain 102 c1vngA_ not modelled 73.3 19 PDB header:haloperoxidase Chain: A: PDB Molecule:vanadium chloroperoxidase; PDBTitle: chloroperoxidase from the fungus curvularia inaequalis:2 mutant h404a 103 c1wv9B_ not modelled 62.3 31 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:rhodanese homolog tt1651; PDBTitle: crystal structure of rhodanese homolog tt1651 from an2 extremely thermophilic bacterium thermus thermophilus hb8 104 c3k35D_ not modelled 55.8 28 PDB header:hydrolase Chain: D: PDB Molecule:nad-dependent deacetylase sirtuin-6; PDBTitle: crystal structure of human sirt6 105 d1ir6a_ not modelled 55.7 30 Fold:DHH phosphoesterases Superfamily:DHH phosphoesterases Family:Exonuclease RecJ 106 c1ir6A_ not modelled 55.7 30 PDB header:hydrolase Chain: A: PDB Molecule:exonuclease recj; PDBTitle: crystal structure of exonuclease recj bound to manganese 107 d1tk9a_ not modelled 55.0 21 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 108 d1vpea_ not modelled 53.2 29 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 109 d16pka_ not modelled 52.8 27 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 110 d1phpa_ not modelled 51.2 27 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 111 c2vy9A_ not modelled 48.2 6 PDB header:gene regulation Chain: A: PDB Molecule:anti-sigma-factor antagonist; PDBTitle: molecular architecture of the stressosome, a signal2 integration and transduction hub 112 c1zmrA_ not modelled 48.2 24 PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of the e. coli phosphoglycerate kinase 113 c1e0cA_ not modelled 46.3 18 PDB header:sulfurtransferase Chain: A: PDB Molecule:sulfurtransferase; PDBTitle: sulfurtransferase from azotobacter vinelandii 114 d1t5oa_ not modelled 46.3 25 Fold:NagB/RpiA/CoA transferase-like Superfamily:NagB/RpiA/CoA transferase-like Family:IF2B-like 115 c3f4aA_ not modelled 45.3 19 PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized protein ygr203w; PDBTitle: structure of ygr203w, a yeast protein tyrosine phosphatase2 of the rhodanese family 116 c2cunA_ not modelled 45.0 17 PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of phosphoglycerate kinase from pyrococcus2 horikoshii ot3 117 c1boiA_ not modelled 43.6 19 PDB header:transferase Chain: A: PDB Molecule:rhodanese; PDBTitle: n-terminally truncated rhodanese 118 d1x92a_ not modelled 43.5 21 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 119 d1qpga_ not modelled 42.5 20 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 120 c1w2wA_ not modelled 42.2 21 PDB header:isomerase Chain: A: PDB Molecule:5-methylthioribose-1-phosphate isomerase; PDBTitle: crystal structure of yeast ypr118w, a methylthioribose-1-2 phosphate isomerase related to regulatory eif2b subunits

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0