Phyre 2 Results for P13009

Email	l.a.kelley@imperial.ac.uk
Description	P13009
Date	Thu Jan 5 11:33:23 GMT 2012
Unique Job ID	040ac6e1ba337e6a

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c1k98A_

Top template information

PDB header:transferase
Chain: A: PDB Molecule:methionine synthase;
PDBTitle: adomet complex of meth c-terminal fragment

Confidence and coverage

Confidence:

100.0%

Coverage:

47%

577 residues ( 47% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

1126 residues ( 92%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M S S K V E Q L R A Q L N E R I L V L D G G M G T M I Q S Y R L N E A D F R G E R F A D W P C D L K G N N D L L V L S K

Secondary structure

SS confidence

Disorder ? ? ? ? ?
? ? ? ? ?
?
? ?
?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence P E V I A A I H N A Y F E A G A D I I E T N T F N S T T I A M A D Y Q M E S L S A E I N F A A A K L A R A C A D E W T A

Secondary structure

SS confidence

Disorder
? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence R T P E K P R Y V A G V L G P T N R T A S I S P D V N D P A F R N I T F D G L V A A Y R E S T K A L V E G G A D L I L I

Secondary structure

SS confidence

Disorder ? ?
?
?
?
?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence E T V F D T L N A K A A V F A V K T E F E A L G V E L P I M I S G T I T D A S G R T L S G Q T T E A F Y N S L R H A E A

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence L T F G L N C A L G P D E L R Q Y V Q E L S R I A E C Y V T A H P N A G L P N A F G E Y D L D A D T M A K Q I R E W A Q

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence A G F L N I V G G C C G T T P Q H I A A M S R A V E G L A P R K L P E I P V A C R L S G L E P L N I G E D S L F V N V G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?
?
?
? ?
? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence E R T N V T G S A K F K R L I K E E K Y S E A L D V A R Q Q V E N G A Q I I D I N M D E G M L D A E A A M V R F L N L I

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence A G E P D I A R V P I M I D S S K W D V I E K G L K C I Q G K G I V N S I S M K E G V D A F I H H A K L L R R Y G A A V

Secondary structure

SS confidence

Disorder
? ?
?
?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence V V M A F D E Q G Q A D T R A R K I E I C R R A Y K I L T E E V G F P P E D I I F D P N I F A V A T G I E E H N N Y A Q

Secondary structure

SS confidence

Disorder
?
? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence D F I G A C E D I K R E L P H A L I S G G V S N V S F S F R G N D P V R E A I H A V F L Y Y A I R N G M D M G I V N A G

Secondary structure

SS confidence

Disorder
?
? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence Q L A I Y D D L P A E L R D A V E D V I L N R R D D G T E R L L E L A E K Y R G S K T D D T A N A Q Q A E W R S W E V N

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence K R L E Y S L V K G I T E F I E Q D T E E A R Q Q A T R P I E V I E G P L M D G M N V V G D L F G E G K M F L P Q V V K

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence S A R V M K Q A V A Y L E P F I E A S K E Q G K T N G K M V I A T V K G D V H D I G K N I V G V V L Q C N N Y E I V D L

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence G V M V P A E K I L R T A K E V N A D L I G L S G L I T P S L D E M V N V A K E M E R Q G F T I P L L I G G A T T S K A

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence H T A V K I E Q N Y S G P T V Y V Q N A S R T V G V V A A L L S D T Q R D D F V A R T R K E Y E T V R I Q H G R K K P R

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence T P P V T L E A A R D N D F A F D W Q A Y T P P V A H R L G V Q E V E A S I E T L R N Y I D W T P F F M T W S L A G K Y

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence P R I L E D E V V G V E A Q R L F K D A N D M L D K L S A E K T L N P R G V V G L F P A N R V G D D I E I Y R D E T R T

Secondary structure

SS confidence

Disorder ? ?
?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence H V I N V S H H L R Q Q T E K T G F A N Y C L A D F V A P K L S G K A D Y I G A F A V T G G L E E D A L A D A F E A Q H

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?
?
? ? ?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence D D Y N K I M V K A L A D R L A E A F A E Y L H E R V R K V Y W G Y A P N E N L S N E E L I R E N Y Q G I R P A P G Y P

Secondary structure

SS confidence

Disorder ?
?
? ? ? ?
? ? ?
?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence A C P E H T E K A T I W E L L E V E K H T G M K L T E S F A M W P G A S V S G W Y F S H P D S K Y Y A V A Q I Q R D Q V

Secondary structure

SS confidence

Disorder
?
?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . .

Sequence E D Y A R R K G M S V T E V E R W L A P N L G Y D A D

Secondary structure

SS confidence

Disorder
? ?
? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 1k98 chain A

Region: 651 - 1227
Aligned: 577
Modelled: 577
Confidence: 100.0%
Identity: 100%
PDB header:transferase
Chain: A: PDB Molecule:methionine synthase;
PDBTitle: adomet complex of meth c-terminal fragment

Phyre2

PDB 3bol chain B

Region: 2 - 620
Aligned: 549
Modelled: 595
Confidence: 100.0%
Identity: 29%
PDB header:transferase
Chain: B: PDB Molecule:5-methyltetrahydrofolate s-homocysteine
PDBTitle: cobalamin-dependent methionine synthase (1-566) from2 thermotoga maritima complexed with zn2+

Phyre2

PDB 1msk chain A

Region: 901 - 1227
Aligned: 327
Modelled: 327
Confidence: 100.0%
Identity: 100%
Fold: Methionine synthase activation domain-like
Superfamily: Methionine synthase activation domain-like
Family: Methionine synthase SAM-binding domain

Phyre2

PDB 2o2k chain A

Region: 900 - 1225
Aligned: 325
Modelled: 326
Confidence: 100.0%
Identity: 49%
PDB header:transferase
Chain: A: PDB Molecule:methionine synthase;
PDBTitle: crystal structure of the activation domain of human2 methionine synthase isoform/mutant d963e/k1071n

Phyre2

PDB 1umy chain A

Region: 8 - 393
Aligned: 334
Modelled: 371
Confidence: 100.0%
Identity: 23%
Fold: TIM beta/alpha-barrel
Superfamily: Homocysteine S-methyltransferase
Family: Homocysteine S-methyltransferase

Phyre2

PDB 3k13 chain A

Region: 353 - 639
Aligned: 286
Modelled: 287
Confidence: 100.0%
Identity: 64%
PDB header:transferase
Chain: A: PDB Molecule:5-methyltetrahydrofolate-homocysteine methyltransferase;
PDBTitle: structure of the pterin-binding domain metr of 5-2 methyltetrahydrofolate-homocysteine methyltransferase from3 bacteroides thetaiotaomicron

Phyre2

PDB 3bof chain A domain 2

Region: 2 - 337
Aligned: 296
Modelled: 319
Confidence: 100.0%
Identity: 33%
Fold: TIM beta/alpha-barrel
Superfamily: Homocysteine S-methyltransferase
Family: Homocysteine S-methyltransferase

Phyre2

PDB 1lt7 chain A

Region: 6 - 369
Aligned: 282
Modelled: 318
Confidence: 100.0%
Identity: 25%
Fold: TIM beta/alpha-barrel
Superfamily: Homocysteine S-methyltransferase
Family: Homocysteine S-methyltransferase

Phyre2

PDB 2yci chain X

Region: 351 - 637
Aligned: 266
Modelled: 287
Confidence: 100.0%
Identity: 25%
PDB header:transferase
Chain: X: PDB Molecule:5-methyltetrahydrofolate corrinoid/iron sulfur protein
PDBTitle: methyltransferase native

Phyre2

PDB 3bof chain A domain 1

Region: 340 - 620
Aligned: 259
Modelled: 280
Confidence: 100.0%
Identity: 24%
Fold: TIM beta/alpha-barrel
Superfamily: Dihydropteroate synthetase-like
Family: Methyltetrahydrofolate-utiluzing methyltransferases

Phyre2

PDB 1bmt chain B

Region: 651 - 896
Aligned: 246
Modelled: 246
Confidence: 100.0%
Identity: 100%
PDB header:methyltransferase
Chain: B: PDB Molecule:methionine synthase;
PDBTitle: how a protein binds b12: a 3.o angstrom x-ray structure of2 the b12-binding domains of methionine synthase

Phyre2

PDB 1f6y chain A

Region: 356 - 637
Aligned: 257
Modelled: 282
Confidence: 100.0%
Identity: 26%
Fold: TIM beta/alpha-barrel
Superfamily: Dihydropteroate synthetase-like
Family: Methyltetrahydrofolate-utiluzing methyltransferases

Phyre2

PDB 2i2x chain D

Region: 661 - 887
Aligned: 215
Modelled: 227
Confidence: 100.0%
Identity: 32%
PDB header:transferase
Chain: D: PDB Molecule:methyltransferase 1;
PDBTitle: crystal structure of methanol:cobalamin methyltransferase complex2 mtabc from methanosarcina barkeri

Phyre2

PDB 3ezx chain A

Region: 655 - 871
Aligned: 208
Modelled: 217
Confidence: 100.0%
Identity: 26%
PDB header:transferase
Chain: A: PDB Molecule:monomethylamine corrinoid protein 1;
PDBTitle: structure of methanosarcina barkeri monomethylamine2 corrinoid protein

Phyre2

PDB 3bul chain A domain 2

Region: 741 - 896
Aligned: 156
Modelled: 156
Confidence: 100.0%
Identity: 99%
Fold: Flavodoxin-like
Superfamily: Cobalamin (vitamin B12)-binding domain
Family: Cobalamin (vitamin B12)-binding domain

Phyre2

PDB 1xrs chain B

Region: 668 - 871
Aligned: 181
Modelled: 201
Confidence: 100.0%
Identity: 19%
PDB header:isomerase
Chain: B: PDB Molecule:d-lysine 5,6-aminomutase beta subunit;
PDBTitle: crystal structure of lysine 5,6-aminomutase in complex with plp,2 cobalamin, and 5'-deoxyadenosine

Phyre2

PDB 1tx2 chain A

Region: 345 - 598
Aligned: 234
Modelled: 254
Confidence: 100.0%
Identity: 21%
PDB header:transferase
Chain: A: PDB Molecule:dhps, dihydropteroate synthase;
PDBTitle: dihydropteroate synthetase, with bound inhibitor manic, from bacillus2 anthracis

Phyre2

PDB 1tx2 chain A

Region: 345 - 598
Aligned: 234
Modelled: 254
Confidence: 100.0%
Identity: 21%
Fold: TIM beta/alpha-barrel
Superfamily: Dihydropteroate synthetase-like
Family: Dihydropteroate synthetase

Phyre2

PDB 1j6r chain A

Region: 945 - 1181
Aligned: 180
Modelled: 222
Confidence: 100.0%
Identity: 17%
Fold: Methionine synthase activation domain-like
Superfamily: Methionine synthase activation domain-like
Family: Hypothetical protein TM0269

Phyre2

PDB 1ad1 chain A

Region: 354 - 598
Aligned: 229
Modelled: 245
Confidence: 100.0%
Identity: 20%
Fold: TIM beta/alpha-barrel
Superfamily: Dihydropteroate synthetase-like
Family: Dihydropteroate synthetase

Phyre2

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Detailed template information

#	Template	Alignment Coverage	3D Model	Confidence	% i.d.	Template Information

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server

Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]

If you use the binding site predictions from 3DLigandSite, please also cite:

3DLigandSite: predicting ligand-binding sites using similar structures.

Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]

Imperial College London

Lawrence Kelley, Benjamin Jefferys

Disclaimer

Terms and Conditions

Component software

Template detection: HHpred 1.51

Secondary structure prediction: Psi-pred 2.5

Disorder prediction: Disopred 2.4

Transmembrane prediction: Memsat_SVM

Multi-template modelling and ab initio: Poing 1.0

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	S	S	K	V	E	Q	L	R	A	Q	L	N	E	R	I	L	V	L	D	G	G	M	G	T	M	I	Q	S	Y	R	L	N	E	A	D	F	R	G	E	R	F	A	D	W	P	C	D	L	K	G	N	N	D	L	L	V	L	S	K
Secondary structure
SS confidence
Disorder	?	?	?	?	?																														?	?	?	?	?					?		?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	P	E	V	I	A	A	I	H	N	A	Y	F	E	A	G	A	D	I	I	E	T	N	T	F	N	S	T	T	I	A	M	A	D	Y	Q	M	E	S	L	S	A	E	I	N	F	A	A	A	K	L	A	R	A	C	A	D	E	W	T	A
Secondary structure
SS confidence
Disorder																																	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	R	T	P	E	K	P	R	Y	V	A	G	V	L	G	P	T	N	R	T	A	S	I	S	P	D	V	N	D	P	A	F	R	N	I	T	F	D	G	L	V	A	A	Y	R	E	S	T	K	A	L	V	E	G	G	A	D	L	I	L	I
Secondary structure
SS confidence
Disorder	?	?																				?			?			?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	E	T	V	F	D	T	L	N	A	K	A	A	V	F	A	V	K	T	E	F	E	A	L	G	V	E	L	P	I	M	I	S	G	T	I	T	D	A	S	G	R	T	L	S	G	Q	T	T	E	A	F	Y	N	S	L	R	H	A	E	A
Secondary structure
SS confidence
Disorder																						?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	L	T	F	G	L	N	C	A	L	G	P	D	E	L	R	Q	Y	V	Q	E	L	S	R	I	A	E	C	Y	V	T	A	H	P	N	A	G	L	P	N	A	F	G	E	Y	D	L	D	A	D	T	M	A	K	Q	I	R	E	W	A	Q
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	A	G	F	L	N	I	V	G	G	C	C	G	T	T	P	Q	H	I	A	A	M	S	R	A	V	E	G	L	A	P	R	K	L	P	E	I	P	V	A	C	R	L	S	G	L	E	P	L	N	I	G	E	D	S	L	F	V	N	V	G
Secondary structure
SS confidence
Disorder																													?	?	?	?	?	?	?	?	?															?		?		?	?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	E	R	T	N	V	T	G	S	A	K	F	K	R	L	I	K	E	E	K	Y	S	E	A	L	D	V	A	R	Q	Q	V	E	N	G	A	Q	I	I	D	I	N	M	D	E	G	M	L	D	A	E	A	A	M	V	R	F	L	N	L	I
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?																																							?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	A	G	E	P	D	I	A	R	V	P	I	M	I	D	S	S	K	W	D	V	I	E	K	G	L	K	C	I	Q	G	K	G	I	V	N	S	I	S	M	K	E	G	V	D	A	F	I	H	H	A	K	L	L	R	R	Y	G	A	A	V
Secondary structure
SS confidence
Disorder			?	?		?																																				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	V	V	M	A	F	D	E	Q	G	Q	A	D	T	R	A	R	K	I	E	I	C	R	R	A	Y	K	I	L	T	E	E	V	G	F	P	P	E	D	I	I	F	D	P	N	I	F	A	V	A	T	G	I	E	E	H	N	N	Y	A	Q
Secondary structure
SS confidence
Disorder																																																		?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	D	F	I	G	A	C	E	D	I	K	R	E	L	P	H	A	L	I	S	G	G	V	S	N	V	S	F	S	F	R	G	N	D	P	V	R	E	A	I	H	A	V	F	L	Y	Y	A	I	R	N	G	M	D	M	G	I	V	N	A	G
Secondary structure
SS confidence
Disorder																	?													?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	Q	L	A	I	Y	D	D	L	P	A	E	L	R	D	A	V	E	D	V	I	L	N	R	R	D	D	G	T	E	R	L	L	E	L	A	E	K	Y	R	G	S	K	T	D	D	T	A	N	A	Q	Q	A	E	W	R	S	W	E	V	N
Secondary structure
SS confidence
Disorder																										?													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	K	R	L	E	Y	S	L	V	K	G	I	T	E	F	I	E	Q	D	T	E	E	A	R	Q	Q	A	T	R	P	I	E	V	I	E	G	P	L	M	D	G	M	N	V	V	G	D	L	F	G	E	G	K	M	F	L	P	Q	V	V	K
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	S	A	R	V	M	K	Q	A	V	A	Y	L	E	P	F	I	E	A	S	K	E	Q	G	K	T	N	G	K	M	V	I	A	T	V	K	G	D	V	H	D	I	G	K	N	I	V	G	V	V	L	Q	C	N	N	Y	E	I	V	D	L
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	G	V	M	V	P	A	E	K	I	L	R	T	A	K	E	V	N	A	D	L	I	G	L	S	G	L	I	T	P	S	L	D	E	M	V	N	V	A	K	E	M	E	R	Q	G	F	T	I	P	L	L	I	G	G	A	T	T	S	K	A
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	H	T	A	V	K	I	E	Q	N	Y	S	G	P	T	V	Y	V	Q	N	A	S	R	T	V	G	V	V	A	A	L	L	S	D	T	Q	R	D	D	F	V	A	R	T	R	K	E	Y	E	T	V	R	I	Q	H	G	R	K	K	P	R
Secondary structure
SS confidence
Disorder																																			?																			?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	T	P	P	V	T	L	E	A	A	R	D	N	D	F	A	F	D	W	Q	A	Y	T	P	P	V	A	H	R	L	G	V	Q	E	V	E	A	S	I	E	T	L	R	N	Y	I	D	W	T	P	F	F	M	T	W	S	L	A	G	K	Y
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?				?																																						?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	P	R	I	L	E	D	E	V	V	G	V	E	A	Q	R	L	F	K	D	A	N	D	M	L	D	K	L	S	A	E	K	T	L	N	P	R	G	V	V	G	L	F	P	A	N	R	V	G	D	D	I	E	I	Y	R	D	E	T	R	T
Secondary structure
SS confidence
Disorder	?	?			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	H	V	I	N	V	S	H	H	L	R	Q	Q	T	E	K	T	G	F	A	N	Y	C	L	A	D	F	V	A	P	K	L	S	G	K	A	D	Y	I	G	A	F	A	V	T	G	G	L	E	E	D	A	L	A	D	A	F	E	A	Q	H
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?											?																													?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	D	D	Y	N	K	I	M	V	K	A	L	A	D	R	L	A	E	A	F	A	E	Y	L	H	E	R	V	R	K	V	Y	W	G	Y	A	P	N	E	N	L	S	N	E	E	L	I	R	E	N	Y	Q	G	I	R	P	A	P	G	Y	P
Secondary structure
SS confidence
Disorder	?																														?						?	?	?	?							?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	A	C	P	E	H	T	E	K	A	T	I	W	E	L	L	E	V	E	K	H	T	G	M	K	L	T	E	S	F	A	M	W	P	G	A	S	V	S	G	W	Y	F	S	H	P	D	S	K	Y	Y	A	V	A	Q	I	Q	R	D	Q	V
Secondary structure
SS confidence
Disorder																			?																																				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.
Sequence	E	D	Y	A	R	R	K	G	M	S	V	T	E	V	E	R	W	L	A	P	N	L	G	Y	D	A	D
Secondary structure
SS confidence
Disorder							?	?														?	?	?	?	?	?
Disorder confidence