Email l.a.kelley@imperial.ac.uk Description P77698 Date Thu Jan 5 12:31:47 GMT 2012 Unique Job ID e615bbdb963a1a78

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2r0qF_ 99.9 20 PDB header:recombination/dna Chain: F: PDB Molecule:putative transposon tn552 dna-invertase bin3; PDBTitle: crystal structure of a serine recombinase- dna regulatory2 complex 2 c3guvA_ 99.9 22 PDB header:recombination Chain: A: PDB Molecule:site-specific recombinase, resolvase family protein; PDBTitle: crystal structure of a resolvase family site-specific recombinase from2 streptococcus pneumoniae 3 c2gm4B_ 99.9 21 PDB header:recombination, dna Chain: B: PDB Molecule:transposon gamma-delta resolvase; PDBTitle: an activated, tetrameric gamma-delta resolvase: hin chimaera bound to2 cleaved dna 4 c3g13B_ 99.9 16 PDB header:recombination Chain: B: PDB Molecule:putative conjugative transposon recombinase; PDBTitle: crystal structure of putative conjugative transposon recombinase from2 clostridium difficile 5 d1gdta2 99.8 20 Fold:Resolvase-like Superfamily:Resolvase-like Family:gamma,delta resolvase, catalytic domain 6 c3bvpB_ 99.8 27 PDB header:recombination Chain: B: PDB Molecule:tp901-1 integrase; PDBTitle: crystal structure of the n-terminal catalytic domain of tp901-12 integrase 7 c3lhkA_ 99.8 19 PDB header:dna binding protein Chain: A: PDB Molecule:putative dna binding protein mj0014; PDBTitle: crystal structure of putative dna binding protein from2 methanocaldococcus jannaschii. 8 d2gm4a2 99.8 20 Fold:Resolvase-like Superfamily:Resolvase-like Family:gamma,delta resolvase, catalytic domain 9 c3lhfC_ 99.8 23 PDB header:recombination Chain: C: PDB Molecule:serine recombinase; PDBTitle: the crystal structure of a serine recombinase from2 sulfolobus solfataricus to 2.3a 10 c3pkzK_ 99.7 23 PDB header:recombination Chain: K: PDB Molecule:recombinase sin; PDBTitle: structural basis for catalytic activation of a serine recombinase 11 d2rsla_ 99.7 24 Fold:Resolvase-like Superfamily:Resolvase-like Family:gamma,delta resolvase, catalytic domain 12 c3ploX_ 99.7 25 PDB header:recombination Chain: X: PDB Molecule:dna-invertase; PDBTitle: crystal structure of the fis-independent mutant of gin 13 d1hx7a_ 99.5 23 Fold:Resolvase-like Superfamily:Resolvase-like Family:gamma,delta resolvase, catalytic domain 14 c1u78A_ 88.4 17 PDB header:dna binding protein/dna Chain: A: PDB Molecule:transposable element tc3 transposase; PDBTitle: structure of the bipartite dna-binding domain of tc32 transposase bound to transposon dna 15 c3cngC_ 86.5 29 PDB header:hydrolase Chain: C: PDB Molecule:nudix hydrolase; PDBTitle: crystal structure of nudix hydrolase from nitrosomonas europaea 16 c1i3qI_ 83.8 15 PDB header:transcription Chain: I: PDB Molecule:dna-directed rna polymerase ii 14.2kd PDBTitle: rna polymerase ii crystal form i at 3.1 a resolution 17 c3ghgK_ 80.4 8 PDB header:blood clotting Chain: K: PDB Molecule:fibrinogen beta chain; PDBTitle: crystal structure of human fibrinogen 18 c1deqF_ 76.5 10 PDB header: PDB COMPND: 19 c2gb5B_ 73.3 20 PDB header:hydrolase Chain: B: PDB Molecule:nadh pyrophosphatase; PDBTitle: crystal structure of nadh pyrophosphatase (ec 3.6.1.22) (1790429) from2 escherichia coli k12 at 2.30 a resolution 20 c2opfA_ 72.2 22 PDB header:hydrolase/dna Chain: A: PDB Molecule:endonuclease viii; PDBTitle: crystal structure of the dna repair enzyme endonuclease-viii (nei)2 from e. coli (r252a) in complex with ap-site containing dna substrate 21 d1k78a2 not modelled 71.3 18 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Paired domain 22 c3h0gI_ not modelled 70.4 13 PDB header:transcription Chain: I: PDB Molecule:dna-directed rna polymerase ii subunit rpb9; PDBTitle: rna polymerase ii from schizosaccharomyces pombe 23 c2k8dA_ not modelled 69.3 9 PDB header:oxidoreductase Chain: A: PDB Molecule:peptide methionine sulfoxide reductase msrb; PDBTitle: solution structure of a zinc-binding methionine sulfoxide reductase 24 d2fiya1 not modelled 68.7 20 Fold:FdhE-like Superfamily:FdhE-like Family:FdhE-like 25 c1k82D_ not modelled 68.7 13 PDB header:hydrolase/dna Chain: D: PDB Molecule:formamidopyrimidine-dna glycosylase; PDBTitle: crystal structure of e.coli formamidopyrimidine-dna2 glycosylase (fpg) covalently trapped with dna 26 d6paxa2 not modelled 68.1 17 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Paired domain 27 d1k78a1 not modelled 68.1 19 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Paired domain 28 c1nnjA_ not modelled 65.6 14 PDB header:hydrolase Chain: A: PDB Molecule:formamidopyrimidine-dna glycosylase; PDBTitle: crystal structure complex between the lactococcus lactis fpg and an2 abasic site containing dna 29 c1deqO_ not modelled 63.8 11 PDB header: PDB COMPND: 30 d2nlya1 not modelled 62.9 7 Fold:7-stranded beta/alpha barrel Superfamily:Glycoside hydrolase/deacetylase Family:Divergent polysaccharide deacetylase 31 c2vrwB_ not modelled 62.8 14 PDB header:signaling protein Chain: B: PDB Molecule:proto-oncogene vav; PDBTitle: critical structural role for the ph and c1 domains of the2 vav1 exchange factor 32 d1twfi1 not modelled 60.8 15 Fold:Rubredoxin-like Superfamily:Zinc beta-ribbon Family:Transcriptional factor domain 33 d1pvma3 not modelled 60.4 21 Fold:Rubredoxin-like Superfamily:Hypothetical protein Ta0289 C-terminal domain Family:Hypothetical protein Ta0289 C-terminal domain 34 d1wo8a1 not modelled 59.9 12 Fold:Methylglyoxal synthase-like Superfamily:Methylglyoxal synthase-like Family:Methylglyoxal synthase, MgsA 35 d1dgsa1 59.1 20 Fold:SAM domain-like Superfamily:RuvA domain 2-like Family:NAD+-dependent DNA ligase, domain 3 36 d1p91a_ not modelled 58.5 35 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:rRNA methyltransferase RlmA 37 c2dq3A_ 57.8 18 PDB header:ligase Chain: A: PDB Molecule:seryl-trna synthetase; PDBTitle: crystal structure of aq_298 38 c2k27A_ not modelled 57.0 19 PDB header:transcription regulator Chain: A: PDB Molecule:paired box protein pax-8; PDBTitle: solution structure of human pax8 paired box domain 39 d1l1da_ not modelled 56.4 8 Fold:Mss4-like Superfamily:Mss4-like Family:SelR domain 40 d1pdnc_ not modelled 55.9 19 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Paired domain 41 c1y1yS_ not modelled 55.4 12 PDB header:transferase/transcription/dna-rna hybrid Chain: S: PDB Molecule:transcription elongation factor s-ii; PDBTitle: rna polymerase ii-tfiis-dna/rna complex 42 c3gn5B_ not modelled 55.4 13 PDB header:dna binding protein Chain: B: PDB Molecule:hth-type transcriptional regulator mqsa (ygit/b3021); PDBTitle: structure of the e. coli protein mqsa (ygit/b3021) 43 d2g9wa1 not modelled 54.8 15 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Penicillinase repressor 44 c1pqvS_ not modelled 54.8 12 PDB header:transferase/transcription Chain: S: PDB Molecule:transcription elongation factor s-ii; PDBTitle: rna polymerase ii-tfiis complex 45 c2f5qA_ not modelled 54.1 27 PDB header:hydrolase/dna Chain: A: PDB Molecule:formamidopyrimidine-dna glycosidase; PDBTitle: catalytically inactive (e3q) mutm crosslinked to oxog:c2 containing dna cc2 46 d6paxa1 not modelled 53.7 19 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Paired domain 47 c2lcqA_ not modelled 53.0 19 PDB header:metal binding protein Chain: A: PDB Molecule:putative toxin vapc6; PDBTitle: solution structure of the endonuclease nob1 from p.horikoshii 48 d1tfia_ not modelled 51.6 18 Fold:Rubredoxin-like Superfamily:Zinc beta-ribbon Family:Transcriptional factor domain 49 d2iw0a1 not modelled 49.8 9 Fold:7-stranded beta/alpha barrel Superfamily:Glycoside hydrolase/deacetylase Family:NodB-like polysaccharide deacetylase 50 c6paxA_ not modelled 48.8 21 PDB header:gene regulation/dna Chain: A: PDB Molecule:homeobox protein pax-6; PDBTitle: crystal structure of the human pax-6 paired domain-dna2 complex reveals a general model for pax protein-dna3 interactions 51 d1dl6a_ not modelled 48.6 15 Fold:Rubredoxin-like Superfamily:Zinc beta-ribbon Family:Transcriptional factor domain 52 c2krfB_ not modelled 48.3 27 PDB header:transcription Chain: B: PDB Molecule:transcriptional regulatory protein coma; PDBTitle: nmr solution structure of the dna binding domain of competence protein2 a 53 d1twfi2 not modelled 47.3 17 Fold:Rubredoxin-like Superfamily:Zinc beta-ribbon Family:Transcriptional factor domain 54 c2riqA_ not modelled 47.0 19 PDB header:transferase Chain: A: PDB Molecule:poly [adp-ribose] polymerase 1; PDBTitle: crystal structure of the third zinc-binding domain of human parp-1 55 c3lssA_ not modelled 46.7 9 PDB header:ligase Chain: A: PDB Molecule:seryl-trna synthetase; PDBTitle: trypanosoma brucei seryl-trna synthetase in complex with atp 56 d1yioa1 not modelled 46.3 18 Fold:DNA/RNA-binding 3-helical bundle Superfamily:C-terminal effector domain of the bipartite response regulators Family:GerE-like (LuxR/UhpA family of transcriptional regulators) 57 c3pfqA_ not modelled 46.0 26 PDB header:transferase Chain: A: PDB Molecule:protein kinase c beta type; PDBTitle: crystal structure and allosteric activation of protein kinase c beta2 ii 58 c3izci_ not modelled 45.6 16 PDB header:ribosome Chain: I: PDB Molecule:60s ribosomal protein rpl10 (l10e); PDBTitle: localization of the large subunit ribosomal proteins into a 6.1 a2 cryo-em map of saccharomyces cerevisiae translating 80s ribosome 59 c2jpcA_ not modelled 45.6 24 PDB header:dna binding protein Chain: A: PDB Molecule:ssrb; PDBTitle: ssrb dna binding protein 60 c1ee8A_ not modelled 45.6 30 PDB header:dna binding protein Chain: A: PDB Molecule:mutm (fpg) protein; PDBTitle: crystal structure of mutm (fpg) protein from thermus thermophilus hb8 61 c2j6aA_ not modelled 45.1 26 PDB header:transferase Chain: A: PDB Molecule:protein trm112; PDBTitle: crystal structure of s. cerevisiae ynr046w, a zinc finger2 protein from the erf1 methyltransferase complex. 62 c1zljE_ not modelled 45.0 15 PDB header:transcription Chain: E: PDB Molecule:dormancy survival regulator; PDBTitle: crystal structure of the mycobacterium tuberculosis hypoxic2 response regulator dosr c-terminal domain 63 d1fsea_ not modelled 44.7 21 Fold:DNA/RNA-binding 3-helical bundle Superfamily:C-terminal effector domain of the bipartite response regulators Family:GerE-like (LuxR/UhpA family of transcriptional regulators) 64 c3hnwB_ not modelled 44.4 18 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a basic coiled-coil protein of unknown function2 from eubacterium eligens atcc 27750 65 c3cezA_ not modelled 44.3 10 PDB header:oxidoreductase Chain: A: PDB Molecule:methionine-r-sulfoxide reductase; PDBTitle: crystal structure of methionine-r-sulfoxide reductase from2 burkholderia pseudomallei 66 d1p6ra_ not modelled 44.1 20 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Penicillinase repressor 67 c3hcjB_ not modelled 44.0 21 PDB header:oxidoreductase Chain: B: PDB Molecule:peptide methionine sulfoxide reductase; PDBTitle: structure of msrb from xanthomonas campestris (oxidized2 form) 68 c2l1uA_ not modelled 43.1 12 PDB header:oxidoreductase Chain: A: PDB Molecule:methionine-r-sulfoxide reductase b2, mitochondrial; PDBTitle: structure-functional analysis of mammalian msrb2 protein 69 c2rnjA_ not modelled 42.3 21 PDB header:transcription Chain: A: PDB Molecule:response regulator protein vrar; PDBTitle: nmr structure of the s. aureus vrar dna binding domain 70 d1x6ma_ not modelled 41.5 33 Fold:Mss4-like Superfamily:Mss4-like Family:Glutathione-dependent formaldehyde-activating enzyme, Gfa 71 c3fxaA_ not modelled 41.1 17 PDB header:sugar binding protein Chain: A: PDB Molecule:sis domain protein; PDBTitle: crystal structure of a putative sugar-phosphate isomerase2 (lmof2365_0531) from listeria monocytogenes str. 4b f2365 at 1.60 a3 resolution 72 d1ivsa1 not modelled 40.9 16 Fold:Long alpha-hairpin Superfamily:tRNA-binding arm Family:Valyl-tRNA synthetase (ValRS) C-terminal domain 73 d1xm0a1 not modelled 40.9 8 Fold:Mss4-like Superfamily:Mss4-like Family:SelR domain 74 d1p4wa_ not modelled 40.9 27 Fold:DNA/RNA-binding 3-helical bundle Superfamily:C-terminal effector domain of the bipartite response regulators Family:GerE-like (LuxR/UhpA family of transcriptional regulators) 75 d1ny1a_ not modelled 40.1 11 Fold:7-stranded beta/alpha barrel Superfamily:Glycoside hydrolase/deacetylase Family:NodB-like polysaccharide deacetylase 76 c2jeeA_ not modelled 39.9 18 PDB header:cell cycle Chain: A: PDB Molecule:yiiu; PDBTitle: xray structure of e. coli yiiu 77 d1r2za3 not modelled 39.2 29 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:C-terminal, Zn-finger domain of MutM-like DNA repair proteins 78 d1ee8a3 not modelled 38.6 33 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:C-terminal, Zn-finger domain of MutM-like DNA repair proteins 79 d1l3la1 not modelled 38.4 12 Fold:DNA/RNA-binding 3-helical bundle Superfamily:C-terminal effector domain of the bipartite response regulators Family:GerE-like (LuxR/UhpA family of transcriptional regulators) 80 d2cona1 not modelled 38.2 36 Fold:Rubredoxin-like Superfamily:NOB1 zinc finger-like Family:NOB1 zinc finger-like 81 c3dtpA_ not modelled 37.8 14 PDB header:contractile protein Chain: A: PDB Molecule:myosin 2 heavy chain chimera of smooth and PDBTitle: tarantula heavy meromyosin obtained by flexible docking to2 tarantula muscle thick filament cryo-em 3d-map 82 c2jvmA_ not modelled 37.8 23 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of rhodobacter sphaeroides protein2 rhos4_26430. northeast structural genomics consortium3 target rhr95 83 d1l1ta3 not modelled 37.6 29 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:C-terminal, Zn-finger domain of MutM-like DNA repair proteins 84 c2w48D_ not modelled 37.6 21 PDB header:transcription Chain: D: PDB Molecule:sorbitol operon regulator; PDBTitle: crystal structure of the full-length sorbitol operon2 regulator sorc from klebsiella pneumoniae 85 d1qypa_ not modelled 37.2 30 Fold:Rubredoxin-like Superfamily:Zinc beta-ribbon Family:Transcriptional factor domain 86 c2jvnA_ not modelled 37.1 19 PDB header:transferase Chain: A: PDB Molecule:poly [adp-ribose] polymerase 1; PDBTitle: domain c of human parp-1 87 d1sd4a_ not modelled 37.1 14 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Penicillinase repressor 88 d1tdza3 not modelled 37.0 29 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:C-terminal, Zn-finger domain of MutM-like DNA repair proteins 89 d1k82a3 not modelled 36.7 17 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:C-terminal, Zn-finger domain of MutM-like DNA repair proteins 90 d1pd0a5 not modelled 36.6 18 Fold:Rubredoxin-like Superfamily:Zn-finger domain of Sec23/24 Family:Zn-finger domain of Sec23/24 91 c3hugA_ not modelled 36.5 17 PDB header:transcription/membrane protein Chain: A: PDB Molecule:rna polymerase sigma factor; PDBTitle: crystal structure of mycobacterium tuberculosis anti-sigma factor rsla2 in complex with -35 promoter binding domain of sigl 92 c3eg9B_ not modelled 35.8 15 PDB header:protein transport Chain: B: PDB Molecule:sec24 related gene family, member d; PDBTitle: crystal structure of the mammalian copii-coat protein2 sec23/24 bound to the transport signal sequence of membrin 93 d1x68a2 not modelled 35.8 40 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 94 d1k3xa3 not modelled 35.3 33 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:C-terminal, Zn-finger domain of MutM-like DNA repair proteins 95 c2w3zA_ not modelled 35.2 6 PDB header:hydrolase Chain: A: PDB Molecule:putative deacetylase; PDBTitle: structure of a streptococcus mutans ce4 esterase 96 c1w17A_ not modelled 35.0 11 PDB header:hydrolase Chain: A: PDB Molecule:probable polysaccharide deacetylase pdaa; PDBTitle: structure of bacillus subtilis pdaa, a family 42 carbohydrate esterase. 97 d1tc3c_ not modelled 34.9 14 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Recombinase DNA-binding domain 98 c1ei3C_ not modelled 34.3 11 PDB header: PDB COMPND: 99 c3eh2B_ not modelled 34.2 12 PDB header:protein transport Chain: B: PDB Molecule:protein transport protein sec24c; PDBTitle: crystal structure of the human copii-coat protein sec24c 100 d1ltla_ not modelled 33.9 12 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:DNA replication initiator (cdc21/cdc54) N-terminal domain 101 c2gajA_ not modelled 33.7 18 PDB header:isomerase Chain: A: PDB Molecule:dna topoisomerase i; PDBTitle: structure of full length topoisomerase i from thermotoga maritima in2 monoclinic crystal form 102 d1ibia2 not modelled 33.6 17 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 103 c2zq0B_ not modelled 33.1 6 PDB header:hydrolase Chain: B: PDB Molecule:alpha-glucosidase (alpha-glucosidase susb); PDBTitle: crystal structure of susb complexed with acarbose 104 c3k7aM_ not modelled 32.6 24 PDB header:transcription Chain: M: PDB Molecule:transcription initiation factor iib; PDBTitle: crystal structure of an rna polymerase ii-tfiib complex 105 c1ei3E_ not modelled 32.6 9 PDB header: PDB COMPND: 106 d1seta1 not modelled 32.5 18 Fold:Long alpha-hairpin Superfamily:tRNA-binding arm Family:Seryl-tRNA synthetase (SerRS) 107 d2eppa1 not modelled 32.4 21 Fold:beta-beta-alpha zinc fingers Superfamily:beta-beta-alpha zinc fingers Family:Classic zinc finger, C2H2 108 d1x94a_ not modelled 32.1 18 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 109 d2dlda2 not modelled 32.0 21 Fold:Flavodoxin-like Superfamily:Formate/glycerate dehydrogenase catalytic domain-like Family:Formate/glycerate dehydrogenases, substrate-binding domain 110 d1okra_ not modelled 31.8 14 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Penicillinase repressor 111 d2c71a1 not modelled 31.7 15 Fold:7-stranded beta/alpha barrel Superfamily:Glycoside hydrolase/deacetylase Family:NodB-like polysaccharide deacetylase 112 c1x3uA_ not modelled 31.3 24 PDB header:transcription Chain: A: PDB Molecule:transcriptional regulatory protein fixj; PDBTitle: solution structure of the c-terminal transcriptional2 activator domain of fixj from sinorhizobium melilot 113 c3bjiA_ not modelled 30.8 14 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: structural basis of promiscuous guanine nucleotide exchange2 by the t-cell essential vav1 114 c1m2vB_ not modelled 30.7 18 PDB header:protein transport Chain: B: PDB Molecule:protein transport protein sec24; PDBTitle: crystal structure of the yeast sec23/24 heterodimer 115 d1gh9a_ not modelled 30.5 23 Fold:Rubredoxin-like Superfamily:Hypothetical protein MTH1184 Family:Hypothetical protein MTH1184 116 c3e0mB_ not modelled 30.5 8 PDB header:oxidoreductase Chain: B: PDB Molecule:peptide methionine sulfoxide reductase msra/msrb PDBTitle: crystal structure of fusion protein of msra and msrb 117 d1vd4a_ not modelled 30.4 13 Fold:Rubredoxin-like Superfamily:Zinc beta-ribbon Family:Transcriptional factor domain 118 c3u50C_ not modelled 30.1 14 PDB header:dna binding protein Chain: C: PDB Molecule:telomerase-associated protein 82; PDBTitle: crystal structure of the tetrahymena telomerase processivity factor2 teb1 ob-c 119 d1m3sa_ not modelled 30.0 13 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 120 c3egxB_ not modelled 30.0 13 PDB header:protein transport Chain: B: PDB Molecule:protein transport protein sec24a; PDBTitle: crystal structure of the mammalian copii-coat protein2 sec23a/24a complexed with the snare protein sec22b and3 bound to the transport signal sequence of the snare protein4 bet1