Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP25516
DateThu Jan 5 11:41:52 GMT 2012
Unique Job IDb6ee1aed79cad8cc

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2b3yB_
Top template information
PDB header:lyase
Chain: B: PDB Molecule:iron-responsive element binding protein 1;
PDBTitle: structure of a monoclinic crystal form of human cytosolic aconitase2 (irp1)
Confidence and coverage
Confidence:100.0% Coverage: 99%
878 residues ( 99% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MSSTLREASKDTLQAKDKTYHYYSLPLAAKSLGDITRLPKSLKVLLENLLRWQDGNSVTE
Secondary structure 
SS confidence 
Disorder  ??????????
??
?????
??????
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  EDIHALAGWLKNAHADREIAYRPARVLMQDFTGVPAVVDLAAMREAVKRLGGDTAKVNPL
Secondary structure 
SS confidence 
Disorder 
???????
?????????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  SPVDLVIDHSVTVDRFGDDEAFEENVRLEMERNHERYVFLKWGKQAFSRFSVVPPGTGIC
Secondary structure 
SS confidence 
Disorder 
?????
?
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  HQVNLEYLGKAVWSELQDGEWIAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQ
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  PVSMLIPDVVGFKLTGKLREGITATDLVLTVTQMLRKHGVVGKFVEFYGDGLDSLPLADR
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  ATIANMSPEYGATCGFFPIDAVTLDYMRLSGRSEDQVELVEKYAKAQGMWRNPGDEPIFT
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  STLELDMNDVEASLAGPKRPQDRVALPDVPKAFAASNELEVNATHKDRQPVDYVMNGHQY
Secondary structure 
SS confidence 
Disorder 
?
?
??????????????
?
???
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  QLPDGAVVIAAITSCTNTSNPSVLMAAGLLAKKAVTLGLKRQPWVKASLAPGSKVVSDYL
Secondary structure 
SS confidence 
Disorder  ???
???
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  AKAKLTPYLDELGFNLVGYGCTTCIGNSGPLPDPIETAIKKSDLTVGAVLSGNRNFEGRI
Secondary structure 
SS confidence 
Disorder 
??
??????????
?
Disorder confidence 
 
   .........550.........560.........570.........580.........590.........600
Sequence  HPLVKTNWLASPPLVVAYALAGNMNINLASEPIGHDRKGDPVYLKDIWPSAQEIARAVEQ
Secondary structure 
SS confidence 
Disorder 
?
?
???
??????
??
Disorder confidence 
 
   .........610.........620.........630.........640.........650.........660
Sequence  VSTEMFRKEYAEVFEGTAEWKGINVTRSDTYGWQEDSTYIRLSPFFDEMQATPAPVEDIH
Secondary structure 
SS confidence 
Disorder  ????????????????????
?
???
?
?
?
????????
?
Disorder confidence 
 
   .........670.........680.........690.........700.........710.........720
Sequence  GARILAMLGDSVTTDHISPAGSIKPDSPAGRYLQGRGVERKDFNSYGSRRGNHEVMMRGT
Secondary structure 
SS confidence 
Disorder 
??????????
??????
?
Disorder confidence 
 
   .........730.........740.........750.........760.........770.........780
Sequence  FANIRIRNEMVPGVEGGMTRHLPDSDVVSIYDAAMRYKQEQTPLAVIAGKEYGSGSSRDW
Secondary structure 
SS confidence 
Disorder 
?
?
Disorder confidence 
 
   .........790.........800.........810.........820.........830.........840
Sequence  AAKGPRLLGIRVVIAESFERIHRSNLIGMGILPLEFPQGVTRKTLGLTGEEKIDIGDLQN
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........850.........860.........870.........880.........890.
Sequence  LQPGATVPVTLTRADGSQEVVPCRCRIDTATELTYYQNDGILHYVIRNMLK
Secondary structure 
SS confidence 
Disorder 
?
??
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2b3y chain B

3D model

Region: 3 - 891
Aligned: 878
Modelled: 889
Confidence: 100.0%
Identity: 52%
PDB header:lyase
Chain: B: PDB Molecule:iron-responsive element binding protein 1;
PDBTitle: structure of a monoclinic crystal form of human cytosolic aconitase2 (irp1)

Phyre2

PDB 5acn chain A

3D model

Region: 22 - 891
Aligned: 747
Modelled: 794
Confidence: 100.0%
Identity: 29%
PDB header:lyase(carbon-oxygen)
Chain: A: PDB Molecule:aconitase;
PDBTitle: structure of activated aconitase. formation of the (4fe-4s)2 cluster in the crystal

Phyre2

PDB 2b3y chain A domain 2

3D model

Region: 8 - 627
Aligned: 614
Modelled: 620
Confidence: 100.0%
Identity: 52%
Fold: Aconitase iron-sulfur domain
Superfamily: Aconitase iron-sulfur domain
Family: Aconitase iron-sulfur domain

Phyre2

PDB 1aco chain A domain 2

3D model

Region: 22 - 618
Aligned: 512
Modelled: 556
Confidence: 100.0%
Identity: 29%
Fold: Aconitase iron-sulfur domain
Superfamily: Aconitase iron-sulfur domain
Family: Aconitase iron-sulfur domain

Phyre2

PDB 1l5j chain A domain 3

3D model

Region: 53 - 614
Aligned: 456
Modelled: 491
Confidence: 100.0%
Identity: 23%
Fold: Aconitase iron-sulfur domain
Superfamily: Aconitase iron-sulfur domain
Family: Aconitase iron-sulfur domain

Phyre2

PDB 1l5j chain B

3D model

Region: 51 - 607
Aligned: 456
Modelled: 493
Confidence: 100.0%
Identity: 22%
PDB header:lyase
Chain: B: PDB Molecule:aconitate hydratase 2;
PDBTitle: crystal structure of e. coli aconitase b.

Phyre2

PDB 2b3y chain A domain 1

3D model

Region: 628 - 891
Aligned: 259
Modelled: 264
Confidence: 100.0%
Identity: 54%
Fold: The "swivelling" beta/beta/alpha domain
Superfamily: LeuD/IlvD-like
Family: LeuD-like

Phyre2

PDB 1aco chain A domain 1

3D model

Region: 631 - 887
Aligned: 222
Modelled: 240
Confidence: 100.0%
Identity: 28%
Fold: The "swivelling" beta/beta/alpha domain
Superfamily: LeuD/IlvD-like
Family: LeuD-like

Phyre2

PDB 1v7l chain A

3D model

Region: 659 - 888
Aligned: 156
Modelled: 160
Confidence: 100.0%
Identity: 35%
Fold: The "swivelling" beta/beta/alpha domain
Superfamily: LeuD/IlvD-like
Family: LeuD-like

Phyre2

PDB 2pkp chain A

3D model

Region: 659 - 890
Aligned: 158
Modelled: 172
Confidence: 100.0%
Identity: 31%
PDB header:lyase
Chain: A: PDB Molecule:homoaconitase small subunit;
PDBTitle: crystal structure of 3-isopropylmalate dehydratase (leud)2 from methhanocaldococcus jannaschii dsm2661 (mj1271)

Phyre2

PDB 1l5j chain A domain 2

3D model

Region: 655 - 890
Aligned: 178
Modelled: 197
Confidence: 100.0%
Identity: 20%
Fold: The "swivelling" beta/beta/alpha domain
Superfamily: LeuD/IlvD-like
Family: LeuD-like

Phyre2

PDB 2hcu chain A

3D model

Region: 649 - 879
Aligned: 175
Modelled: 200
Confidence: 100.0%
Identity: 25%
PDB header:lyase
Chain: A: PDB Molecule:3-isopropylmalate dehydratase small subunit;
PDBTitle: crystal structure of smu.1381 (or leud) from streptococcus2 mutans

Phyre2

PDB 3q3w chain B

3D model

Region: 659 - 879
Aligned: 166
Modelled: 191
Confidence: 100.0%
Identity: 23%
PDB header:transferase
Chain: B: PDB Molecule:3-isopropylmalate dehydratase small subunit;
PDBTitle: isopropylmalate isomerase small subunit from campylobacter jejuni.

Phyre2

PDB 3h5j chain A

3D model

Region: 659 - 879
Aligned: 161
Modelled: 173
Confidence: 100.0%
Identity: 27%
PDB header:lyase
Chain: A: PDB Molecule:3-isopropylmalate dehydratase small subunit;
PDBTitle: leud_1-168 small subunit of isopropylmalate isomerase (rv2987c) from2 mycobacterium tuberculosis

Phyre2

PDB 1cf1 chain A domain 1

3D model

Region: 790 - 818
Aligned: 29
Modelled: 29
Confidence: 71.8%
Identity: 14%
Fold: Immunoglobulin-like beta-sandwich
Superfamily: E set domains
Family: Arrestin/Vps26-like

Phyre2

PDB 1g4m chain A domain 1

3D model

Region: 790 - 818
Aligned: 29
Modelled: 29
Confidence: 69.4%
Identity: 28%
Fold: Immunoglobulin-like beta-sandwich
Superfamily: E set domains
Family: Arrestin/Vps26-like

Phyre2

PDB 2r4q chain A domain 1

3D model

Region: 429 - 462
Aligned: 31
Modelled: 34
Confidence: 63.9%
Identity: 35%
Fold: Phosphotyrosine protein phosphatases I-like
Superfamily: PTS system IIB component-like
Family: PTS system, Fructose specific IIB subunit-like

Phyre2

PDB 3c52 chain B

3D model

Region: 86 - 151
Aligned: 60
Modelled: 66
Confidence: 59.5%
Identity: 30%
PDB header:lyase
Chain: B: PDB Molecule:fructose-bisphosphate aldolase;
PDBTitle: class ii fructose-1,6-bisphosphate aldolase from2 helicobacter pylori in complex with3 phosphoglycolohydroxamic acid, a competitive inhibitor

Phyre2

PDB 2isw chain B

3D model

Region: 86 - 151
Aligned: 60
Modelled: 66
Confidence: 54.4%
Identity: 28%
PDB header:lyase
Chain: B: PDB Molecule:putative fructose-1,6-bisphosphate aldolase;
PDBTitle: structure of giardia fructose-1,6-biphosphate aldolase in2 complex with phosphoglycolohydroxamate

Phyre2

PDB 1t3v chain A

3D model

Region: 733 - 825
Aligned: 89
Modelled: 93
Confidence: 43.3%
Identity: 11%
Fold: Ribonuclease H-like motif
Superfamily: Nitrogenase accessory factor-like
Family: MTH1175-like

Phyre2
1
c2b3yB_
2
c5acnA_
3
d2b3ya2
4
d1acoa2
5
d1l5ja3
6
c1l5jB_
7
d2b3ya1
8
d1acoa1
9
d1v7la_
10
c2pkpA_
11
d1l5ja2
12
c2hcuA_
13
c3q3wB_
14
c3h5jA_
15
d1cf1a1
16
d1g4ma1
17
d2r4qa1
18
c3c52B_
19
c2iswB_
20
d1t3va_
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
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44
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46
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53
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73
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2b3yB_
100.0 52 PDB header:lyase
Chain: B: PDB Molecule:iron-responsive element binding protein 1;
PDBTitle: structure of a monoclinic crystal form of human cytosolic aconitase2 (irp1)
2c5acnA_
100.0 29 PDB header:lyase(carbon-oxygen)
Chain: A: PDB Molecule:aconitase;
PDBTitle: structure of activated aconitase. formation of the (4fe-4s)2 cluster in the crystal
3d2b3ya2
100.0 52 Fold:Aconitase iron-sulfur domain
Superfamily:Aconitase iron-sulfur domain
Family:Aconitase iron-sulfur domain
4d1acoa2
100.0 29 Fold:Aconitase iron-sulfur domain
Superfamily:Aconitase iron-sulfur domain
Family:Aconitase iron-sulfur domain
5d1l5ja3
100.0 23 Fold:Aconitase iron-sulfur domain
Superfamily:Aconitase iron-sulfur domain
Family:Aconitase iron-sulfur domain
6c1l5jB_
100.0 22 PDB header:lyase
Chain: B: PDB Molecule:aconitate hydratase 2;
PDBTitle: crystal structure of e. coli aconitase b.
7d2b3ya1
100.0 54 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:LeuD/IlvD-like
Family:LeuD-like
8d1acoa1
100.0 28 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:LeuD/IlvD-like
Family:LeuD-like
9d1v7la_
100.0 35 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:LeuD/IlvD-like
Family:LeuD-like
10c2pkpA_
100.0 31 PDB header:lyase
Chain: A: PDB Molecule:homoaconitase small subunit;
PDBTitle: crystal structure of 3-isopropylmalate dehydratase (leud)2 from methhanocaldococcus jannaschii dsm2661 (mj1271)
11d1l5ja2
100.0 20 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:LeuD/IlvD-like
Family:LeuD-like
12c2hcuA_
100.0 25 PDB header:lyase
Chain: A: PDB Molecule:3-isopropylmalate dehydratase small subunit;
PDBTitle: crystal structure of smu.1381 (or leud) from streptococcus2 mutans
13c3q3wB_
100.0 23 PDB header:transferase
Chain: B: PDB Molecule:3-isopropylmalate dehydratase small subunit;
PDBTitle: isopropylmalate isomerase small subunit from campylobacter jejuni.
14c3h5jA_
100.0 27 PDB header:lyase
Chain: A: PDB Molecule:3-isopropylmalate dehydratase small subunit;
PDBTitle: leud_1-168 small subunit of isopropylmalate isomerase (rv2987c) from2 mycobacterium tuberculosis
15d1cf1a1
71.8 14 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Arrestin/Vps26-like
16d1g4ma1
69.4 28 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Arrestin/Vps26-like
17d2r4qa1
63.9 35 Fold:Phosphotyrosine protein phosphatases I-like
Superfamily:PTS system IIB component-like
Family:PTS system, Fructose specific IIB subunit-like
18c3c52B_
59.5 30 PDB header:lyase
Chain: B: PDB Molecule:fructose-bisphosphate aldolase;
PDBTitle: class ii fructose-1,6-bisphosphate aldolase from2 helicobacter pylori in complex with3 phosphoglycolohydroxamic acid, a competitive inhibitor
19c2iswB_
54.4 28 PDB header:lyase
Chain: B: PDB Molecule:putative fructose-1,6-bisphosphate aldolase;
PDBTitle: structure of giardia fructose-1,6-biphosphate aldolase in2 complex with phosphoglycolohydroxamate
20d1t3va_
43.3 11 Fold:Ribonuclease H-like motif
Superfamily:Nitrogenase accessory factor-like
Family:MTH1175-like
21d1rdua_
not modelled 40.8 15 Fold:Ribonuclease H-like motif
Superfamily:Nitrogenase accessory factor-like
Family:MTH1175-like
22c3elfA_
not modelled 40.2 24 PDB header:lyase
Chain: A: PDB Molecule:fructose-bisphosphate aldolase;
PDBTitle: structural characterization of tetrameric mycobacterium tuberculosis2 fructose 1,6-bisphosphate aldolase - substrate binding and catalysis3 mechanism of a class iia bacterial aldolase
23d1dosa_
not modelled 34.8 38 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class II FBP aldolase
24d2r48a1
not modelled 31.6 39 Fold:Phosphotyrosine protein phosphatases I-like
Superfamily:PTS system IIB component-like
Family:PTS system, Fructose specific IIB subunit-like
25d1p90a_
not modelled 29.5 16 Fold:Ribonuclease H-like motif
Superfamily:Nitrogenase accessory factor-like
Family:Nitrogenase accessory factor
26d1o13a_
not modelled 26.4 13 Fold:Ribonuclease H-like motif
Superfamily:Nitrogenase accessory factor-like
Family:MTH1175-like
27c2gp4A_
not modelled 25.2 14 PDB header:lyase
Chain: A: PDB Molecule:6-phosphogluconate dehydratase;
PDBTitle: structure of [fes]cluster-free apo form of 6-phosphogluconate2 dehydratase from shewanella oneidensis
28c2yx6C_
not modelled 24.7 15 PDB header:structural genomics, unknown function
Chain: C: PDB Molecule:hypothetical protein ph0822;
PDBTitle: crystal structure of ph0822
29d1o60a_
not modelled 23.7 16 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I DAHP synthetase
30c3bolB_
not modelled 23.7 21 PDB header:transferase
Chain: B: PDB Molecule:5-methyltetrahydrofolate s-homocysteine
PDBTitle: cobalamin-dependent methionine synthase (1-566) from2 thermotoga maritima complexed with zn2+
31c3qm3C_
not modelled 23.6 23 PDB header:lyase
Chain: C: PDB Molecule:fructose-bisphosphate aldolase;
PDBTitle: 1.85 angstrom resolution crystal structure of fructose-bisphosphate2 aldolase (fba) from campylobacter jejuni
32c2wbrA_
not modelled 23.5 31 PDB header:dna-binding protein
Chain: A: PDB Molecule:gw182;
PDBTitle: the rrm domain in gw182 proteins contributes to mirna-2 mediated gene silencing
33c3q94B_
not modelled 23.0 28 PDB header:lyase
Chain: B: PDB Molecule:fructose-bisphosphate aldolase, class ii;
PDBTitle: the crystal structure of fructose 1,6-bisphosphate aldolase from2 bacillus anthracis str. 'ames ancestor'
34c3l2iB_
not modelled 22.7 15 PDB header:lyase
Chain: B: PDB Molecule:3-dehydroquinate dehydratase;
PDBTitle: 1.85 angstrom crystal structure of the 3-dehydroquinate dehydratase2 (arod) from salmonella typhimurium lt2.
35d1gvfa_
not modelled 22.5 21 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class II FBP aldolase
36d1t0tv_
not modelled 22.3 23 Fold:Ferredoxin-like
Superfamily:Dimeric alpha+beta barrel
Family:Chlorite dismutase-like
37d1rvga_
not modelled 21.4 29 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class II FBP aldolase
38c3iz5Q_
not modelled 19.9 22 PDB header:ribosome
Chain: Q: PDB Molecule:60s ribosomal protein l5 (l18p);
PDBTitle: localization of the large subunit ribosomal proteins into a 5.5 a2 cryo-em map of triticum aestivum translating 80s ribosome
39c2rhbD_
not modelled 19.8 33 PDB header:viral protein
Chain: D: PDB Molecule:uridylate-specific endoribonuclease;
PDBTitle: crystal structure of nsp15-h234a mutant- hexamer in2 asymmetric unit
40d3bofa2
not modelled 19.4 19 Fold:TIM beta/alpha-barrel
Superfamily:Homocysteine S-methyltransferase
Family:Homocysteine S-methyltransferase
41d1iuka_
not modelled 19.2 20 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:CoA-binding domain
42c2kyrA_
not modelled 19.1 24 PDB header:transferase
Chain: A: PDB Molecule:fructose-like phosphotransferase enzyme iib component 1;
PDBTitle: solution structure of enzyme iib subunit of pts system from2 escherichia coli k12. northeast structural genomics consortium target3 er315/ontario center for structural proteomics target ec0544
43c2wfbA_
not modelled 18.7 19 PDB header:biosynthetic protein
Chain: A: PDB Molecule:putative uncharacterized protein orp;
PDBTitle: high resolution structure of the apo form of the orange2 protein (orp) from desulfovibrio gigas
44d1vdha_
not modelled 18.7 18 Fold:Ferredoxin-like
Superfamily:Dimeric alpha+beta barrel
Family:Chlorite dismutase-like
45d2aioa1
not modelled 18.4 19 Fold:Metallo-hydrolase/oxidoreductase
Superfamily:Metallo-hydrolase/oxidoreductase
Family:Zn metallo-beta-lactamase
46d1eo1a_
not modelled 17.4 22 Fold:Ribonuclease H-like motif
Superfamily:Nitrogenase accessory factor-like
Family:MTH1175-like
47c3c3jA_
not modelled 16.7 10 PDB header:isomerase
Chain: A: PDB Molecule:putative tagatose-6-phosphate ketose/aldose isomerase;
PDBTitle: crystal structure of tagatose-6-phosphate ketose/aldose isomerase from2 escherichia coli
48c3dmyA_
not modelled 16.3 25 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:protein fdra;
PDBTitle: crystal structure of a predicated acyl-coa synthetase from e.coli
49d1eg7a_
not modelled 16.1 19 Fold:P-loop containing nucleoside triphosphate hydrolases
Superfamily:P-loop containing nucleoside triphosphate hydrolases
Family:Nitrogenase iron protein-like
50c3l4gI_
not modelled 16.0 33 PDB header:ligase
Chain: I: PDB Molecule:phenylalanyl-trna synthetase alpha chain;
PDBTitle: crystal structure of homo sapiens cytoplasmic phenylalanyl-trna2 synthetase
51d2ghra1
not modelled 16.0 19 Fold:Flavodoxin-like
Superfamily:Class I glutamine amidotransferase-like
Family:HTS-like
52c2yrvA_
not modelled 15.8 24 PDB header:transcription
Chain: A: PDB Molecule:at-rich interactive domain-containing protein 4a;
PDBTitle: solution structure of the rbb1nt domain of human2 rb(retinoblastoma)-binding protein 1
53c2oxlA_
not modelled 15.2 14 PDB header:gene regulation
Chain: A: PDB Molecule:hypothetical protein ymgb;
PDBTitle: structure and function of the e. coli protein ymgb: a protein critical2 for biofilm formation and acid resistance
54d2ac7a1
not modelled 15.1 17 Fold:Phosphorylase/hydrolase-like
Superfamily:Purine and uridine phosphorylases
Family:Purine and uridine phosphorylases
55d2gp4a2
not modelled 14.9 12 Fold:IlvD/EDD N-terminal domain-like
Superfamily:IlvD/EDD N-terminal domain-like
Family:lvD/EDD N-terminal domain-like
56d2ieaa3
not modelled 14.6 29 Fold:TK C-terminal domain-like
Superfamily:TK C-terminal domain-like
Family:Transketolase C-terminal domain-like
57d2zdra1
not modelled 14.0 23 Fold:beta-clip
Superfamily:AFP III-like domain
Family:AFP III-like domain
58d1jjca_
not modelled 13.9 21 Fold:Class II aaRS and biotin synthetases
Superfamily:Class II aaRS and biotin synthetases
Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain
59c2vxhF_
not modelled 13.7 9 PDB header:oxidoreductase
Chain: F: PDB Molecule:chlorite dismutase;
PDBTitle: the crystal structure of chlorite dismutase: a detox enzyme2 producing molecular oxygen
60c3cf4A_
not modelled 13.6 16 PDB header:oxidoreductase
Chain: A: PDB Molecule:acetyl-coa decarboxylase/synthase alpha subunit;
PDBTitle: structure of the codh component of the m. barkeri acds complex
61c3qpbB_
not modelled 13.5 21 PDB header:transferase
Chain: B: PDB Molecule:uridine phosphorylase;
PDBTitle: crystal structure of streptococcus pyogenes uridine phosphorylase2 reveals a subclass of the np-i superfamily
62c2o8vA_
not modelled 13.1 20 PDB header:oxidoreductase
Chain: A: PDB Molecule:phosphoadenosine phosphosulfate reductase;
PDBTitle: paps reductase in a covalent complex with thioredoxin c35a
63c3mwbA_
not modelled 13.1 15 PDB header:lyase
Chain: A: PDB Molecule:prephenate dehydratase;
PDBTitle: the crystal structure of prephenate dehydratase in complex with l-phe2 from arthrobacter aurescens to 2.0a
64c2jz2A_
not modelled 13.0 11 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:ssl0352 protein;
PDBTitle: solution nmr structure of ssl0352 protein from synechocystis sp. pcc2 6803. northeast structural genomics consortium target sgr42
65d1k6ka_
not modelled 12.9 25 Fold:Double Clp-N motif
Superfamily:Double Clp-N motif
Family:Double Clp-N motif
66c2r2dC_
not modelled 12.5 21 PDB header:hydrolase
Chain: C: PDB Molecule:zn-dependent hydrolases;
PDBTitle: structure of a quorum-quenching lactonase (aiib) from agrobacterium2 tumefaciens
67c2w9mB_
not modelled 12.5 35 PDB header:dna replication
Chain: B: PDB Molecule:polymerase x;
PDBTitle: structure of family x dna polymerase from deinococcus2 radiodurans
68c1pt1B_
not modelled 12.5 19 PDB header:lyase
Chain: B: PDB Molecule:aspartate 1-decarboxylase;
PDBTitle: unprocessed pyruvoyl dependent aspartate decarboxylase with histidine2 11 mutated to alanine
69c2ebbA_
not modelled 12.4 18 PDB header:lyase
Chain: A: PDB Molecule:pterin-4-alpha-carbinolamine dehydratase;
PDBTitle: crystal structure of pterin-4-alpha-carbinolamine2 dehydratase (pterin carbinolamine dehydratase) from3 geobacillus kaustophilus hta426
70d1vjta1
not modelled 12.3 28 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:LDH N-terminal domain-like
71d1ppya_
not modelled 11.6 19 Fold:Double psi beta-barrel
Superfamily:ADC-like
Family:Pyruvoyl dependent aspartate decarboxylase, ADC
72d1vhwa_
not modelled 11.5 20 Fold:Phosphorylase/hydrolase-like
Superfamily:Purine and uridine phosphorylases
Family:Purine and uridine phosphorylases
73c1z34A_
not modelled 11.5 18 PDB header:transferase
Chain: A: PDB Molecule:purine nucleoside phosphorylase;
PDBTitle: crystal structure of trichomonas vaginalis purine nucleoside2 phosphorylase complexed with 2-fluoro-2'-deoxyadenosine
74c3nn4C_
not modelled 11.3 9 PDB header:oxidoreductase
Chain: C: PDB Molecule:chlorite dismutase;
PDBTitle: structure of chlorite dismutase from candidatus nitrospira defluvii2 r173k mutant
75c2gacD_
not modelled 11.2 30 PDB header:hydrolase
Chain: D: PDB Molecule:glycosylasparaginase;
PDBTitle: t152c mutant glycosylasparaginase from flavobacterium2 meningosepticum
76d1lt7a_
not modelled 10.9 20 Fold:TIM beta/alpha-barrel
Superfamily:Homocysteine S-methyltransferase
Family:Homocysteine S-methyltransferase
77d1p9ea_
not modelled 10.9 19 Fold:Metallo-hydrolase/oxidoreductase
Superfamily:Metallo-hydrolase/oxidoreductase
Family:Methyl parathion hydrolase
78c1p9eA_
not modelled 10.9 19 PDB header:hydrolase
Chain: A: PDB Molecule:methyl parathion hydrolase;
PDBTitle: crystal structure analysis of methyl parathion hydrolase from2 pseudomonas sp wbc-3
79d1ybfa_
not modelled 10.9 20 Fold:Phosphorylase/hydrolase-like
Superfamily:Purine and uridine phosphorylases
Family:Purine and uridine phosphorylases
80c2kmfA_
not modelled 10.7 28 PDB header:photosynthesis
Chain: A: PDB Molecule:photosystem ii 11 kda protein;
PDBTitle: solution structure of psb27 from cyanobacterial photosystem2 ii
81c1b70A_
not modelled 10.7 21 PDB header:ligase
Chain: A: PDB Molecule:phenylalanyl-trna synthetase;
PDBTitle: phenylalanyl trna synthetase complexed with phenylalanine
82c3do6B_
not modelled 10.6 18 PDB header:ligase
Chain: B: PDB Molecule:formate--tetrahydrofolate ligase;
PDBTitle: crystal structure of putative formyltetrahydrofolate2 synthetase (tm1766) from thermotoga maritima at 1.85 a3 resolution
83d1hyua4
not modelled 10.6 23 Fold:Thioredoxin fold
Superfamily:Thioredoxin-like
Family:PDI-like
84d1uf2c1
not modelled 10.4 21 Fold:A virus capsid protein alpha-helical domain
Superfamily:A virus capsid protein alpha-helical domain
Family:Phytoreovirus capsid
85d1je0a_
not modelled 10.4 20 Fold:Phosphorylase/hydrolase-like
Superfamily:Purine and uridine phosphorylases
Family:Purine and uridine phosphorylases
86c3fz5C_
not modelled 10.3 14 PDB header:isomerase
Chain: C: PDB Molecule:possible 2-hydroxychromene-2-carboxylate isomerase;
PDBTitle: crystal structure of possible 2-hydroxychromene-2-carboxylate2 isomerase from rhodobacter sphaeroides
87d1umya_
not modelled 10.3 20 Fold:TIM beta/alpha-barrel
Superfamily:Homocysteine S-methyltransferase
Family:Homocysteine S-methyltransferase
88c2nu8D_
not modelled 10.2 18 PDB header:ligase
Chain: D: PDB Molecule:succinyl-coa ligase [adp-forming] subunit alpha;
PDBTitle: c123at mutant of e. coli succinyl-coa synthetase
89c1p0yA_
not modelled 10.1 18 PDB header:transferase
Chain: A: PDB Molecule:ribulose-1,5 bisphosphate carboxylase/oxygenase
PDBTitle: crystal structure of the set domain of lsmt bound to2 melysine and adohcy
90c3r2nC_
not modelled 9.9 26 PDB header:hydrolase
Chain: C: PDB Molecule:cytidine deaminase;
PDBTitle: crystal structure of cytidine deaminase from mycobacterium leprae
91d3c8ya1
not modelled 9.8 17 Fold:Fe-only hydrogenase
Superfamily:Fe-only hydrogenase
Family:Fe-only hydrogenase
92d2pt0a1
not modelled 9.8 13 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Myo-inositol hexaphosphate phosphohydrolase (phytase) PhyA
93c2v4oB_
not modelled 9.6 29 PDB header:hydrolase
Chain: B: PDB Molecule:multifunctional protein sur e;
PDBTitle: crystal structure of salmonella typhimurium sure at 2.752 angstrom resolution in monoclinic form
94c3bjeA_
not modelled 9.1 19 PDB header:transferase
Chain: A: PDB Molecule:nucleoside phosphorylase, putative;
PDBTitle: crystal structure of trypanosoma brucei nucleoside phosphorylase shows2 uridine phosphorylase activity
95d1th7a1
not modelled 9.1 23 Fold:Sm-like fold
Superfamily:Sm-like ribonucleoproteins
Family:Sm motif of small nuclear ribonucleoproteins, SNRNP
96c3oqhB_
not modelled 8.9 20 PDB header:ligase
Chain: B: PDB Molecule:putative uncharacterized protein yvmc;
PDBTitle: crystal structure of b. licheniformis cdps yvmc-blic
97c2phjA_
not modelled 8.9 31 PDB header:hydrolase
Chain: A: PDB Molecule:5'-nucleotidase sure;
PDBTitle: crystal structure of sure protein from aquifex aeolicus
98c3bl5E_
not modelled 8.9 19 PDB header:hydrolase
Chain: E: PDB Molecule:queuosine biosynthesis protein quec;
PDBTitle: crystal structure of quec from bacillus subtilis: an enzyme2 involved in preq1 biosynthesis
99d1pvda3
not modelled 8.7 23 Fold:Thiamin diphosphate-binding fold (THDP-binding)
Superfamily:Thiamin diphosphate-binding fold (THDP-binding)
Family:Pyruvate oxidase and decarboxylase PP module

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction 

Transmembrane helices have been predicted in your sequence to adopt the topology shown below


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0