>ss_pred
CCCCCCHHHHHEEEECCCCCCEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEHHHHHCCCCCCCCCCCCEECCCEEEECCCCCCCCCCCHHEEECCCHHHHHHHHCCCCEEEECCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHHHCCCHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHCCCHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCCEECCCCCCCCCCCCEEECCCCCEECHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCEEEEEEECCCCCHHHHCCCCCEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEEEEEECCHHHHHHHHCCCHHHHHHHHHHC
>ss_conf
962034566522550781101002788741255312373137989998875347666899999998720012788860366312023311103799999999899998629998992855886699817623023568578888888787431768999999987508807840898603445435310000135666687221751574276656655200000046668999997189488710997899997126888766999999999850278611599977715412899787667665351301135101678999999870999768778888766410024789998520699999210623640675810300687820000012233222211122221012355655355664679999568788758999999998888997498668883189950968999999987987899987989937752001378888772001100235851157751678889988983222465046777677752102455432434556787702642057784678888863272111333233446770101300467776566765420017742233223345542013870799857855724333686556657411568761988445433221034324432100013100112247666661131277742022467888987299779994378787810899987156608169997018888763175630576882676898783578860698336111378973899997599826899999861999999999829848999988829
>batch____
MSSTLREASKDTLQAKDKTYHYYSLPLAAKSLGDITRLPKSLKVLLENLLRWQDGNSVTEEDIHALAGWLKNAHADREIAYRPARVLMQDFTGVPAVVDLAAMREAVKRLGGDTAKVNPLSPVDLVIDHSVTVDRFGDDEAFEENVRLEMERNHERYVFLKWGKQAFSRFSVVPPGTGICHQVNLEYLGKAVWSELQDGEWIAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPVSMLIPDVVGFKLTGKLREGITATDLVLTVTQMLRKHGVVGKFVEFYGDGLDSLPLADRATIANMSPEYGATCGFFPIDAVTLDYMRLSGRSEDQVELVEKYAKAQGMWRNPGDEPIFTSTLELDMNDVEASLAGPKRPQDRVALPDVPKAFAASNELEVNATHKDRQPVDYVMNGHQYQLPDGAVVIAAITSCTNTSNPSVLMAAGLLAKKAVTLGLKRQPWVKASLAPGSKVVSDYLAKAKLTPYLDELGFNLVGYGCTTCIGNSGPLPDPIETAIKKSDLTVGAVLSGNRNFEGRIHPLVKTNWLASPPLVVAYALAGNMNINLASEPIGHDRKGDPVYLKDIWPSAQEIARAVEQVSTEMFRKEYAEVFEGTAEWKGINVTRSDTYGWQEDSTYIRLSPFFDEMQATPAPVEDIHGARILAMLGDSVTTDHISPAGSIKPDSPAGRYLQGRGVERKDFNSYGSRRGNHEVMMRGTFANIRIRNEMVPGVEGGMTRHLPDSDVVSIYDAAMRYKQEQTPLAVIAGKEYGSGSSRDWAAKGPRLLGIRVVIAESFERIHRSNLIGMGILPLEFPQGVTRKTLGLTGEEKIDIGDLQNLQPGATVPVTLTRADGSQEVVPCRCRIDTATELTYYQNDGILHYVIRNMLK
>UniRef50_D1RJ83(57-945:946) Aconitate hydratase 1 n=2 Tax=Legionella longbeachae D-4968 RepID=D1RJ83_LEGLO  E=0 s/c=1.30 id=64% cov=100%
LTSEFHKSTQQILSINGIDYHYYSLRAAEQgGLKDLSKLPYTLKILLENLLRHLDRQSVTVDDLKAIIEWLKLKTSNREIVYRPARVLMQDFTGVPAIVDLAAMRAAIEKLGGNPEQINPLSAVDLIIDHSIQIDQFLISDAFTINATMEMERNYERYEFLRWGQKAFRNFRVVPPDTGICHQVNLEYLAKTVWTQEINGKIHAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPISLLIPEVIGVKLTGQLQEGITATDLVLSVTHLLREKGVVGKFVEFFGDGLRHLSLADRATISNMSPEYGATCGFFPIDEATLDYLRLSGREEQSVALVEAYAKIQGLWHDPQVELVYTDLVTLDLSTIRACIAGPKRPQDQVELSNLANTF--DKFLVENKRSEERE--QSFSTDVNYELHHGDVVIAAITSCTNTSNPNVLIAAGLLAKKAVEKGMTRKPWVKTSFAPGSQVVTLYLEKTNLQKYLNELGFTLAGYGCTTCIGNSGPLPEPVEKTVIENDLIVSAVLSGNRNFEGRIHPLVKANWLASPPLVVAFALAGTVLIDVTKDPLGEDKSGNPVYLKDLWPTNDEIAREVANITSKMFHDTYANIFMGTKEWRAMKVSESDTYAWPMDSTYIQHPPFFDGMGVTPEKIKNIKGARILALFGDSITTDHISPAGSIKPESPAGEYLQSKGVLIKDFNSYGSRRGNHEVMVRGTFANIRIRNEMTPELEGGFTKYIPTSEIMSIYDAAMRYKKAHTALVVIAGKEYGTGSSRDWAAKGPKLQGVVAVVAESFERIHRSNLIGMGILPLEFPEGVTRKTLNITGSELIDiIGLTHQMKPRMRVKVVIHREDGNQTEVTLISRIDTLNELDYYKNGGILHYVLRGMLK
>UniRef50_A9WRB0(1-946:949) Aconitate hydratase n=29 Tax=Bacteria RepID=A9WRB0_RENSM   E=0 s/c=1.09 id=60% cov=99%
--------SKGVLNVAGTEYEIFRL----SSVEGSKDLPFSLKVLLENLLRTEDGANITADHVHALGNWDPNAQPDTEIQFTPARVIMQDFTGVPCVVDLATMREAVKELGGDPTRVNPLAPAELVIDHSVQIDVFGNANAVERNMEIEYQRNGERYQFLRWGQTAFDDFKVVPPGTGIVHQVNLEYLARTVMTREVGGVLRAYPDTVVGTDSHTTMINGIGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLSGAIPAGATATDVVLTITEQLRKHGVVGKFVEFFGEGVAAVPLANRATIGNMSPEFGSTAAIFPIDQVTIDYLKLTGRPDDNVALVEAYAKEQGLWHDPEHEPKFSEYLELDLSTVVPSISGPKRPQDRIQLTDakeqfrkdlhnyvavghediedgsvdesLDESFPASdspsfNHADNHATDSDRKvlvsaangafgrssnPAKVSMsDGREFELDHGAVSIASITSCTNTSNPSVMLAAAVLARNAVNKGLVSKPWVKTSVAPGSKVVTDYYEKSGLIPYLEKLGFFTVGYGCATCIGNSGPLEDEISAAIQDKDLAVTAVLSGNRNFEGRINPDVKMNYLASPPLVIAYALSGSMDFDFDADPLGQDEAGNNVFLHDIWPDPVEVQKVMdDSIDKEMFVSSYASVFEGDDRWKSIPTPEGNTFDWDPNSTYVQKPPYFDGMTMELTPVQDIVGARVLAKLGDSVTTDHISPAGSFKSDSPAGKYLLEKGVDRKDFNSYGSRRGNHQVMIRGTFANIRLRNQLLagenngAGVEGGFTRDFTQDNgpQNTIYDAAQNYAAAGTQLVVLAGKEYGSGSSRDWAAKGTALLGVKAVVAESYERIHRSNLIGMGVVPLQYPEGENAATLDLDGTETFAVTGLTELNEGrtpKTLKVTATKADGTEKSFDAVVRIDTPGEADYYRNGGILQYVLRQI--
>UniRef50_C6C4C0(1-889:900) Aconitate hydratase 1 n=14 Tax=Bacteria RepID=C6C4C0_DICDC   E=0 s/c=1.68 id=69% cov=100%
MPSQRRDACINTLAIRQNTYAYFSLSLAAKWLGNVDKLPKSLKILFENLLRHYGGEFVQEADLQALVAWQEHGHVDREIAFQPTRVLMQDFTGVPAVVDLAAMRDSVKRLGGNVSRVNPMTPVDLVIDHSVTVDHFGDAQSLADNTRLEMARNHERYAFLRWGQRAFQHFRVVPPGTGICHQVNLEYLAKVVWSQRRGTSLLVFPDSLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPVSMLIPDVVGFRLTGKLAPGITATDLVLTVTQMLRRHGVVGKFVEFFGDGLDTLPLADRATLANMAPEYGATCGFFPVDAVTLDYLRLTNRSEEQIALVEAYSKRQGLWRQPGDEPCFSSRLELDMSTVEASLAGPRRPQDRVALADVPEAFRASQALSTTTAETRRREKPIA-GGEPAPLDAGAVVIAAITSCTNTSNPRVLMTAGLLARNAVSRGLRSKTWVKTSLAPGSRVVTDYLARSGLLAPLTTLGFHLVGYGCTTCIGNAGPLSDAIEAAIRQNDLSVAAVLSGNRNFEGRIHPLVKTNWLASPPLVVAYALAGNIRVDLTRDALGNDAQGHPVYLRDIWPDEAEVAATLQCVSAEQFRHEYAAVFEGSEEWRAIAVGEEPTYRWPADSTYIRRPPFFDEMTHQPPPVNDISEARILALLGDSVTTDHISPAGSIRSESPAGRYLLQSGVAEPDFNAYGARRGNHEVMMRGTFANVRIRNEMVPGREGGFTRHIPSQQEMTIYDAAVRYRDAGIPLVVIAGKEYGSGSSRDWAAKGPRLLGVRAVMAESFERIHRSNLIGMGVLPLEFPAGTSRHTLRLTGDERVFVAGLDALQPGAPVTVIFRRDDGETQHVDMRCRIDTANELAYYQHGGILQYVIRKMV-
>UniRef50_Q4JVM4(10-933:936) Aconitate hydratase n=205 Tax=cellular organisms RepID=ACON_CORJK   E=0 s/c=1.55 id=58% cov=98%
--------SKSTLQVGEKSYDYFALDA----VPGMEKLPYSLKVLGENLLRNEDGKNITREHIEAIANWDPSAEPNFEIQFTPARVIMQDFTGVACIVDLATIRDAVVALGGDADDVNPLNPAEMVIDHSVIIEAFGDSDALEKNVEIEYQRNDERYKFLRWGTGAFENFRVVPPGTGIVHQVNIEYLARSVF----DNNGLAYPDTCVGTDSHTTMENGLGILGWGVGGIEAEAAMLGQPISMLIPRVVGFKLTGEIPTGVTATDVVLTITDMLRQHGVVGKFVEFYGKGVGELPLANRATIGNMSPEFGSTAAMFPIDEETVKYLELTGRDQETLERVEAYAKAQGMWLDPEKEVEYSEYLELDLSTVVPSIAGPKRPQDRIELNDSKAQFRKDLhnyveadasavtpdfdaegpatentsaqtagtpasaadakgnipSAAAGAEGRPSNPVTVNYNGEDIELDHGMVAIASITSCTNTSNPSVMVGAGLLARNAAAKGLKSAPWVKTSMAPGSQVVNGYYEKAGLWKDLEAMGFYLVGYGCTTCIGNSGPLPEEISAGINEGDLAATAVLSGNRNFEGRINPDVKMNYLASPILVIAYAIAGTMDFDFETQPLGQDQDGNDVFLKDIWPSTEDIEEVIaSSITKDLYAEDYANVFEGDERWRSLDVPSGKTFDWDPKSTYIRKAPYFDGMSKEPEAVNDVKGARVLALLGDSVTTDHISPASTIKPGTPAAQYLDANGVERKDYNSLGARRGNHEVMVRGTFANIRLQNQLLDGVSGGYTRDFTQegGPQSFIYDAAMNYQKENTPLVVLGGKEYGTGSSRDWAAKGTLLLGVKAVIAESFERIHRSNLIGMGVVPLQFPEGESWKSLGIEGTETFDIEGIEELNNGstpKTVKVTATKENGEKIEFDAVTRIDTPGEADYYRNGGILQFVLRNMM-
>UniRef50_D1R8M2(18-952:958) Putative uncharacterized protein n=1 Tax=Parachlamydia acanthamoebae str. Hall's coccus RepID=D1R8M2_9CHLA  E=0 s/c=1.50 id=53% cov=98%
---------------NDQKRYYYSLPaLEEQKIAKISRLPISIRIMLESLMRNCDGKRVRKEDVERLANWSAKGPYEGEVPFVVSRVILQDFTGVPLLVDLTAMRDAVAERKLDATLIEPEVPVDLVIDHSVQVDRSGTKNAFDFNLKVEFERNQERYEFLRWGQQAFKTFKVVPPGIGIVHQVNLEHIAKVVFVNKKNGVLIISPDTLVGTDSHTTMINGLGVLGWGVGGIEAEGAMLDQPNVLQLPEVIGVHLSGRLSEGVTATDLTLAITQLLRKENVVGKFVEFFGEGTASLTVADRATIGNMAPEYGATTGYFPVDEKTLEYLHLTGRDEKDITLIEEYLKAQNLFGVPKKgEIDFTKVLELDLSSLKPAVAGPKRPQDRIDLINLKSKFLEIIKTPVKNGGYGKtdedlqQAVGVHSNGtvsitvphdtggtyvldtkqkeepawdevemvtnrpfnsaitdpgygeaekCDIILKHGSIVIAAITSCTNTSNPSVMLGAGLLAKKAVEKGLKVNPLVKTSLAPGSRVVTDYFEKADLQKYFDALGFQLVAYGCTTCIGNSGPLDDNIEKAIKDYDLIAASVLSGNRNFEARIHSAVKANFLMSPPLVIAFAIAGRVDIDFEKEPLGIGKDGNPVFLKDIWPSTEEIQKtIAKSIDPSMFKNRYGRILEDNPIWQNIQVNSGGVYEWDETSSYIQKPPYFDGFTTELPPRIPLQNLRPLALFGDSVTTDHISPAGSIGADTPAGKYLLSLGIKKEDFNSYGSRRGNHHVMVRGTFANVRIRNRMAGDKEGGFTKLMPEGTVMPIFDACQIYGEKNVPLIVFAGKDYGMGSSRDWAAKGSALLGVKAVVAQSFERIHRTNLIGMGVLPLQFKPDESWESLGITGDETFSLIGIENhITSKQEVTLEIKKGN-EIKKAQLILRLDTPIEIEYYLHGGILPYVLRHIL-
>UniRef50_B1YCP0(4-871:878) Aconitate hydratase 1 n=6 Tax=Thermoproteaceae RepID=B1YCP0_THENV   E=0 s/c=1.52 id=52% cov=97%
----------DAIEVGGKAFRFYSLRSLRGEGYDVDRLPYSIRVLVENVMRNLDGRSITEEHLERLLRWSPKAPSG-EVAIKISRVVMQDYTGVPAVVDLATMRDIAVKMGMDPSVVNPRVPVDLIIDHSVQVDFWGSREALRKNLELEIQRNRERYRFLKWAQQAFKNLRVFPPGTGIIHQVNLEHLAKVV---VADGD-LAYFETLVGMDSHTTMINGLGVVGWGVGGVEAEAAMLGEPITIKVPRVVGVYLYGEPRPGVTSTDIVLAITETLRKVDVVDAFVEFYGEGVRRLSVPDRATVANMAPEYGSTMGLFPVDENTLSYLRATGRPEEHVALVRRYYESQGVFGGVE-GAEYSQVVEFDLSAVDRNVAGPTLPWQRRPLSEVPASFALFLQER---KKRTRKAVEIEIDGRRVQFGDGDVVIAAITSCTNTSNPYLLAAAGLVAKRAVELGIRPPPYVKTSFAPGSRAAAEMLERSGLQRYLDELGFHVVAYGCTTCIGNSGPLPPPVAKAIREHDIVAAAVLSGNRNFEGRVHPDVKAAYLASPPLVVAYALAGTVLRDLEREPLAYTPEGRPVYLRDLWPRPEEVNRVVEEgMDPSAYVEKYSKIGELVPEWSALEAPSGLLYRWRADDTYIQPSPLFEG----EAGVSDILGARALLILGDNITTDHISPAGGISADNPAGQYLLSLGVKPAEFNTFGARRGNWQVMVRGAFSSKGYRNK-IGNLEGGLTVKQPEGRVMSVFEAAEAYRKEGTPVIVIAGKNYGAGSSRDWAAKGPKLLGVKAVVAESFERIHRSNLAMVGILPIQLPPGVTVDSLRLDGTETFDILGIsDGLAPGKEVTLRIRRRDGSAEEVRAKLAIYTWAEAEYIKHGGILPYVLKRIL-
>UniRef50_D0RN59(3-869:875) Aconitate hydratase 1 (Citrate hydro-lyase 1) (Aconitase1) n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN59_9RICK  E=0 s/c=1.40 id=45% cov=97%
--------SFKKITIQNQDYDVADI----SNINDIQKIPFSYRILIENIIR-QSLLGRNENANQQVKSILDNKIGSA-INFAPNRILSHDILGKVMLVDFLAYREALQKKGISSDSIQPDVPVDVVIDHSLQVDFFGNDEAKIKNLQKEYERNSERFSFLRWCSKFLDKVNVIPPGVGICHQVNIEYLSKVIWREKKQGHNLMHPDTCIGTDSHTPMVNAIGVMGWGVGGVEAEISMLGRTIPMTVPEVVGVNLKNNLKEGITSTDLVLHITKLLRENKVVGSFIEFFGDGVENLTVGDRATISNMAPEYGATNVLFPVDNSTLDYLKMTGRTDEEIKIVEEYSKNQKLWRNPGDAPMYNRVLELDLDSITPCVSGPKNPEDKINLDQFSS---LANEHSQMLYKKDLRNEEFEVPKLGFKIKDADIMIAAITSCTNTANPKNVIAAGLIAKKLVELGIKRNEKVKTSFAPGSKVTAEILSQTGLQKYLDELGFNMVGIGCTTCNGSSGPLDDNIANTIEKEKVFSIAVLSGNRNFQGRIHPNIRASYLASPGLIVLFSILGTIKKDLTKDSLGKDKDGKDVYFKDVWPSNEDVNKIINQFyKSETFSEKYKEVNDGGDLWEGLQVSNSSNYDWPE-STYIKKPPYMSNTENN--VIKDINLARPIVLLGDSVTTDHISPSSVITKGTAAWDYLTELGLDPKDFNNYLTRRANHEIVARSTFASLRLRNLMTPDQEGSITVKYPENKTMRLYEVAMGYQKENKEIIVLAGENYGCGSSRDVAAKGPLLIGVRAIVAKSFERIHRSNLVGMGLLPLEFEKGQGIEELKIMSTDQFSIIGLDKIsNDNKKVTMKIHKDSGDVIDVKLNVRLDVPEEVTFWKNGGILP--------
>UniRef50_UPI0001AEF098(22-872:887) aconitate hydratase n=1 Tax=Streptomyces ghanaensis ATCC 14672 RepID=UPI0001AEF098  E=0 s/c=1.35 id=47% cov=95%
--------CLRTLPAGDASgepLRYYSLAAAEaNGAGPLGDLPWSLRTLVEGILRRQGHPQVLPEHVRALA----RRDGSAAVPFFPGRVLLQDASGIPVLADLVTLLERAAADGLDRSALEPVLPLDLVVDHALEVDEYASGAAASRNIDLEYMRHHDRYRFLRWAQERLPGLRVVPPGVGICHQLNLEVLAPVVTTEDSHGTRVAALDSLVGTDSHITMINALGVTGWGVGGIEATAAALGQAVMIRVPRVVGVELTGRLAPGVFASDLALTLAQRLRELDVVGAVVEFHGPGLASLSVPDRATVANMAPEYGATMAWFPADRRTLAYLATTGRSPEQVHLTERYLKAQGLLHTPaGPVPRFDTGITLALDSVSTTLAGPARPHEALAPAEVPATLGAARP------------------------RDGDVAIAAITSCTNTSNPRSLVAAGLLARNAVEAGLRPAAWTKTSLTPGSRAAADLLASAGLQKYLDELGFHVAGFGCGTCMGNSGPLSPALDATARAGGTALAAVVSGNRNFTGRIHPEVAHAYLASPAMVVAYALAGNVRTNPETEPLGRAADGSPVVLADLWPDEREIDDLLSAHEAASLGRG-ARRSLTTERWLALEHPRDDTYPWDGETGSIRRPPFTDADLTGPAVDAELLGARPLLVLGDAVTTDHISPVARILPDSAAGRWLIERGVDERALGTFSSRRLNHDVMVRGGFANPRLSNHLAPDKEGGWTRTAPDRTPVPVHAAAEYHRRRGTPLVVVAGDMYGAGSARDWAAKVTRLLGVRAVLARSFERIHRTNLVALGVLPVQW-EGPSPDL--FDGSEEIDLLGIDDLASSTSATVRVRRGDRVLWDGAAECRIDTPLELEWLRAGGLFGHLL-----
>UniRef50_C6KTY5(55-873:890) Aconitate hydratase n=1 Tax=uncultured bacterium RepID=C6KTY5_9BACT   E=0 s/c=1.32 id=44% cov=92%
-------------------------------------LPRSLDLLIRNARRAADQDDIIA---RAVAAWRAGDEAGPEIEIGPTRILMQDTAGIAALVDLAALRDFAAENGTPPERIEPQVAIDLVIDHSVSVDLAGSGDAAERNLQLEFSRNAERYAFFRWAEKAFRTLNIVPPGNGICHQINLEQLANVATRQ-ADGVLI--PELLIGTDSHTTMVNALGVLGWGVGGIEAEAVALGQTLSMRLPNVTAIHVTGRREPGISATDIALTLTATLRDLGVVGHIVEVFGPGLDDLTLADRATLANMAPEYGATCTLFPVDDETLAYLRRTGRDPAHIRDTEQFAKDTGLWRGDEHDRAYSRVVEFDLASVRPTIAGPGRPHQTSTPAAVALRYAPSRDPVEAAPAAAIAAGAVAIASI--------------TSCTNTANPDLMIAAGLACRKARKLGLKPKPWVKTSFSPGSRATAALLRDTGLQEDMDALGFQVTGFGCMTCVGNSGRLKPEMDAYLDAGGRDACAILSGNRNFEFRIHNRIADNYLMSPARVVLGALAGTMAFDPAVEPLGLAPDGSPIHAHDILPSEDEVARLRLAASADGVQ---DQTRASNALWDALPAPDGSRFPWVDASAAIRRPPFFN--REAPLLRSEIVGARPLLVLGDNVTTDHISPIGRITAGSPAGRWLET--AEAAGLESYGACRGNHEVMMRGTFAHPGLRNALAGERAGPWTAIAGEDGLVDVFEAAGHYAATQVPLVVFAGANYGMGSARDWAAKGTLLLGVRAVIAESFERIHRANLAGVGVLPLQLPPGTTCAALGIRKDTTVTLRGLGGFrRPGMSVTMILDTPGEAPSITTLTLRLDTAREVAVAEKGGLF---------
>UniRef50_B3MUF4(1-564:565) GF20674 n=1 Tax=Drosophila ananassae RepID=B3MUF4_DROAN   E=0 s/c=1.52 id=53% cov=63%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLLPEVIGYKLEGKLGPLATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLSYMDQT-----------------------TQDPVYTESATLDLSTVVTSVSGPKRPHDRVSVSGMLEDFKSCLISPVGFKGFAVSPDALKAsgefqwdDGKSYKIGHGSVVIAAITSCTNTSHPSVMLGAGLLAKKAVEKGLNILPYIKTSLSPGSGVVTYYLRESGVIPYLEKLGFDIVGYGFMTCIGNSGPLHENVVNTIEKNGLVCCGVLSGNRNFEGRIHPNTRANYLASPP--------------------------------------------------------GSKIQLGSQDWETLQVSERS-----EASTYIKRPPFFQDMTRELPKLSGIANARCLLMLGDSVTTDHISPAGSIARRSPAARYLAERGLTPRDFNSYGSRRGNDAVMARGTFANIRLFNKLA-SRTGPTTIHVPSGEELDIFDAAEKYRSEGTPLVLLVGKDYGSGSSRLWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSAETLKLSGRETYNIDLPSGLKPGQRIQVEA-----DGNIFDTTLRFDTEVDITYFKNGGILNYMIRKML-
>UniRef50_B2VXW9(84-896:899) Aconitate hydratase, mitochondrial n=3 Tax=cellular organisms RepID=B2VXW9_PYRTR  E=6e-80 s/c=0.37 id=32% cov=77%
---------------------------------------------------------------------------------RPDRVACQDATAQMAILQFMS-------AGLPSVAT----PTTVHCDHLIEAQVGGEKDLARAN-----EINKEVYNFLSTSCAKY-NIGFWKPGSGIIHQIVLE--------------NYAFPGAlLIGTDSHTPNAGGLGMAAIGVGGADAVDVMAGLPWELKAPKVIGVKLTGKLSGWTAPKDIILKVAGILTVKGGTGAIVEYHGPGTESLSCTGMATICNMGAEIGATTSVFPFNDRMYDYLAATKRRD-----IGDFSREYASQLREDEGAQYDELIEINLDELEPHINGPFTPDLATPISKFKEAVKANNW--------------------PEELKVGL-----IGSCTNSSYED-MSRAASIAEDAMAHGVKAKSLF--TVTPGSEQIRATIARDGQLKTFEEFGGMVLANACgpvtlddgqdenalatgsTTnlndapdaimpydgrCMpidrdivddydtpttssamgtddGTSdstapyGTRDAPINLDVHDYNTPTAGysfgfdgvsdftlmddlastmaspltcgasdvdgqwdrkdvkkgqansiISSYNRNFTGRndANPAT-HSFVTSPDLVVAMTIAGTLNFNPLTDEL-TGADGKKFKLKE--PT-----------GAGLPANGYD--------------PGQDTYQAPPEdraSVSVAVSPTSDRLQlLSPFSAWDGKDAKNLPILikcqGKT-TTDHISMAGP---------WLKYRGHLDNISNN----------MLIGA------IN--AENGEANKVKNALNGEYGAVPDVARDYKKNGVPWVVIGDWNYGEGSSREHAALEPRHLGGAAIITRSFARIHETNLKKQGMLPLTFSDPADYDKIG--PNDRVDLA-STELAPGKPLTMTVHPADGSKEFQIKLSHTFNEGQIEWFKNGSALNTMAKN---
>UniRef50_C7NAZ1(27-648:656) Aconitate hydratase n=3 Tax=Bacteria RepID=C7NAZ1_LEPBD   E=2e-69 s/c=0.43 id=32% cov=69%
-----------------------------------------------------------------------------EIAVRVNQTLTQDSTGTMAYLQLNAM---------NVDKVATEVSVAYV-DHNM--------------LQSSFE-NADDHEFIK-TSAAKHNIIFSKPGNGICHRLHLERFGK-------PGKI------LIGSDSHTPTGGGLGMLAIGAGGLDVAIGMARGLYYLKVPKVYNIELRGKLQPWVSAKDVILYVLKELTVKGGVGYVMEYTGEGIKSLSVEDRATITNMGAELGATTSIFPSDEYTKTFLEKQSRGEDFVELL------------PDEDAFYDDKLIVNLDELVPLAAFPHSPD---NVHEIPEEKLKVDQI-------------------------------AIGSCTNSSYSDFMKLAAIL------DGKRVHPDVSLVLSPGSSNIMKMISENNALAKFIAAGARLLEAACGPCIG--------MGQAPKTNGI---SLRTFNRNFKGRCGTMSAGVYLVSTETAAASALTGYL-----TDP---RELGEEIIIKE--PEKFE-------TSDNYFIFPNADENEAKKEREAVEIIMGPN---------IQPFPIGEELKDTFTK-------KVILKTKDNITTDDICPSN--------AALLPFRSNIPK------------------------------------LSEHCFETIIPDFKERAEK----NNGGIVVGGENYGQGSSREHAALLPLYLGIKAVIAKSFARIHKANLINSGIIPLEFENVEDYN--KIDEYDELQLSDIKNsLKNGTFIIKNITKNIEFPAKFNG-----SERELKILKFGGYLKF-------
>UniRef50_D0L8D8(3-652:674) Aconitate hydratase n=12 Tax=Bacteria RepID=D0L8D8_GORB4   E=1e-62 s/c=0.38 id=31% cov=69%
------------------------------------------------------------------------MSPGSEIALRIDQTLTQDATGTLVMQEL---------EGLELDRARTEVSVQYV-DH---------------NLLQTDEKNAEDHDYLRTACARY-GLWYSKPGNGVSH--------------PTHMQRFGIPgKTMVGSDSHTPAAGSLGMLAIGVGGLEVALAIAGHPLNIRMPEIWGVRLEGELPQWCSAKDVIL---EMLRRHDVkggVNRIIEYHGPGLAGLTAMDRHVIANMGAELGATTSVFPSDDAVREFLAAEGREDDWIELL------------ADDDASYDVEETIDLSEIEPLIAKPSSPGNVVPVREVA-----------------GEPISQVVIGSSANPGLRDFAIAA-----------AMVA----DRQTV-------PEVSFDINPTSREILTDLTMMGATANLVIGGARIHQAGCMGCIGM-GQAPATGSNSLRTMP----------RNFPGRSGTTEDSVWLCSPETATASALTGVI-----TDP------------RD-WAADVDMAypeldlPQQHSINTAMLVE-----PPPADEAQKVEPVKGPN---------ISSLPELDDLPDE-------IEAPVLLKLGDNISTDEISPAG--------ARALPFRSNIPKlaDF---------------------------------SFTRV---DETYP--DRARE--AESTGHVIVGGDNYGQGSSREHAAIAPRHLGLRIVIAKSFARIHWQNLANFGVLAVEFDDESDYDD-----IDQDDVLHVENLRDTLESKDEINVHNVTKdKTFTVRHRL-SARQIADVLAGGLIPRLA-----
>UniRef50_B8MG01(264-751:896) Aconitase, mitochondrial, putative n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8MG01_TALSN  E=1e-40 s/c=0.35 id=30% cov=52%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIGADSHTCSGGSVSCLAVGMGATDVIMPLVTGQTWLTVPETVHLRLINEPPFGVGGKDTVLYILKTFkRNTIAADRIVEFSGPGLAALSCDARFAIANMCTEFGAVSGIFAADDRTLDFV---NR-----RRIRKH-KNNAIYFQPDEDAIYAQSFEIDLSKVESGVAIYPSPDNVVPASEV---------------------VGTALDGCF------------IGACTTTEEDLIM--AGLVLEAGLKKGLKPVDHGRRIVVPGSKPIRHKLEKLGLIEIYKQCGFKVGVPGCSMCVG------QGVDQAAAGEKWLS----SQNRNFKNRMGPGSIANLAsaatvaassfsmqMSNPR----ELLDMIDRDRLKEYLGFEPSAQ-------------ISLVSGKsemnTSTLIFSEPYGRDENTSNSAEgGIPNTSGNaLFADEGLSTAIQ--------------------GKVL-RLGDFVDTDAIIPS----------KFLASS-------------RTNEEL--------------------GSHCMEFfmPEFRQL---------VRDGHD-VVVAGRAFGCGSSRDVAVNALLGAGVKCVIAESFSFIYSRNQPNIGLL-------------------------------------------------------------------------------
>UniRef50_B2J8P2(169-564:569) Homoaconitate hydratase family protein n=3 Tax=Cyanobacteria RepID=B2J8P2_NOSP7  E=1e-36 s/c=0.40 id=34% cov=35%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDVVSPGeaTGICH---------VLLPEK----GFVRPGMIIaGTDSHTCTYGALGAFSTGVGttdmaNIYATGDM-----WIRIPPTLVFELSGTLPPKISAKDIILFILGQIGCAGATSKVMEFRGSILAQLPFDERLTLANMAVECGAICGLIVPDEVTREYLK--NRVSEE---------FQEIIGDADAE--YERVYQFDLSSLEPQVARPPKPDRVVAIS---------------------------------QLENIPITKAFIGSCT---------GGKLydLAQAAeVLKGRQLADGVNLFIVPATIEIREQAQELGYIDIFEQAGAQILKTGCGACI-NSgfGVLAKE------ETGIYAT-----NRNFKGRSGDPTGKNYLASPRTVAISAVNGKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2TDH6(319-644:655) 3-isopropylmalate dehydratase n=5 Tax=Burkholderiales RepID=B2TDH6_BURPP  E=3e-36 s/c=0.48 id=32% cov=34%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGTDSHTPHSGALGCLAFGAGATEiANSWVTGY-VRCKVPETLRIEISGQLRDGVTAKDVVLHLLQMdaIRSGGAIGLVFEYGGSAVRAMSIDERATLTNMVAELGGFTGIVEPDERTVAFLK----ERRGVDFTlENWMKS-------DAGATYRDTISIDASAIQPMLARPGDPGNGVPALQLEQDVAIDIAYGGSCTAGKREDFDFYHE----VLHWG-----------------------------VEQGLRVPEGTRLYLQFGTMAVRAYCEERGYLPVFERAGVTLVMPGCGSC-ANCGP-----GQSAEANEVTISAI---NRNFPGRSGP--GNVWLASPYTVAASALAGKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0LGR1(272-649:659) Aconitate hydratase domain protein n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LGR1_HALO1  E=1e-35 s/c=0.41 id=31% cov=37%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GICHQVAREQ--------------IIEPgDFIQATDSHTCMGGASGALSWGVGATEYAALIYWGFTPISVPESIRFELTGSLPPGVTAKDVMLHIldTYAKRE-DTLNRVMEFGGEGLFALSPDERATLANMATECSARGAVMECDDTMLEWIA-SRREDVSAAALKSKAVA------PDPGASYAGGVHvIDLAEIAPMVATPGDP-DR--------GIASDPKNGARISGLDQVAIDIAYGGSCTAGKRDDIDFYA----------KVM-------EEAERAGKRVAEGVSFYLQFGSREVAEYARERGYLGLFERTGVEIIEPGCGACIG-CGP------GVSTQPDQVTVSAI--NRNYKGRSGP--GKLYLASPLTVAASAVVGRI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1Z9U1(201-541:560) 3-isopropylmalate dehydratase, large subunit n=4 Tax=Bacteria RepID=C1Z9U1_PLALI  E=6e-35 s/c=0.45 id=28% cov=34%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSHTSTHGAFGSIAFGIGTSQVADVLATQTLALARPKVRKIEVTGQLKPGVYAKDVILHIIRKLGVQGGVGYAYEYAGDVFDRMSMEERMTVCNMSIEGGARCGYINPDQTTVDYIQ--GRPFAPQG--EEFERAAKWWLSlaSGKDAQFDDVVVFKAEEIEPTVTWGITPAQSVG---VKETLPTISSFPADDQKVISEAFQYMDLKEGQPIQGLKINVAFIGSCTNGRISDLREAARIVKGRHVAAG------VKALVVPGSQLVRKQAMEEGLDKIFEEAGFEWRGAGCSMCLAMN---PDKL-----QGNEVCAS--SSNRNFKGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2GN26(75-720:797) Homoaconitase, mitochondrial n=23 Tax=Dikarya RepID=LYS4_CHAGB   E=2e-33 s/c=0.23 id=31% cov=57%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAGRGIGHQIMIE-------------EGYAWPGTLtVASDSHSNMYGGVAALGTPVVRTDAASIwATGQ-TWWQIPPIAKVTFTGVLPRGVTGKDVIIALCALFNQDEVLNHAIEFTGSDltLSSLPIDDRLTISNMTTEWGAVAGIFPIDSTLKSWL----RAKATVSAMLNpdlggkaritHDKIEELFRDppkPDLGATYAKSLYLNLSTLSPFVAGP-------------------------------NSVKVATPVKDLEAQNIKINKAYLVSCTN-SRASDIAAAANVFREAANGGpiPKVAPGVEFYISAASLPEQEIAEQAGDWRVLLDAGCIENPASCNACIGlGRGLLQP--------GD---VGISASNRNWNGRMgSPQAKA-YLASPEVVAASALKGEIAgpgwyekpEGVEKVIIGEGTG-------DLEADRAvSIADALESLVaqAESMISSAEKSLESSP-----AAATGAVGNAMADAT---------ADQAGEEGLIDILPGFPEKVSGeivfcdsDNINTDGIYP----------GKY------------TY-----QDDI-TRDTMAQVVMEN----------------------YDRSfASLAKPGD--ILVAGFNFGCGSSREQAATAILAKGIPLVVAGSFGNIFSRNSINnalMGV--------------------------------------------------------------------------------
>UniRef50_P07264(119-671:779) 3-isopropylmalate dehydratase n=577 Tax=cellular organisms RepID=LEUC_YEAST  E=2e-33 s/c=0.27 id=26% cov=59%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLATQTIIQAKSKNMRITVNGKLSPGITSKDLILYIIGLIGTAGGTGCVIEFAGEAIEALSMEARMSMCNMAIEAGARAGMIKPDETTFQYTK--GRPLAPKGA--EWEKAVAYWKTlkTDEGAKFDHEINIEAVDVIPTITWGTSPQDALPITgSVPDPKNVTDPIKKSGMERALAYMGLEPNTPLKSIKVDKVFIG---SCTNGRIEDLRSAA------AVVRGQKLASNIKLAMvVPGSGLVKKQAEAEGLDKIFQEAGFEWREAGCSICLGMNPDILDAYERCASTS----------NRNFEGR-QGALSRTHLMSPAMAAAAGIAGHfVDIrEFEYKDQDQSSPKVEVTSED----EKELESAAYDHAEPVQPEDAPQDIANDEL-KDIPVKSDDT-PAKPSSSGMKP---FLTLEGISAPLDKA-----------NVDTDAIIPK----------QFLKTI-----------KRTG----LKKGLFYEWRFRKD-----------DQGKDQETDFVLNVEPWREAEI--LVVTGDNFGCGSSREhapWALKD---FGIKSIIAPSYGDIFYNNSFKNGLLPIRLD--------------------------------------------------------------------------
>UniRef50_A5UUP5(129-465:474) 3-isopropylmalate dehydratase large subunit n=60 Tax=Bacteria RepID=LEUC_ROSS1  E=5e-33 s/c=0.43 id=30% cov=37%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIVCGDSHTSTHGAFGALAFGIGTSEVAHVLATQCLIQTRPKTMEVRVDGRLAPGVTAKDIILAIIA---RYGVgagTGHVFEYTGETIRALSMEERMTICNMSIEGGARAGMIAPDDTTFEYIA--GRPFAPKG--KAWDEAVAYWRTlpTDEGAVYDRIITLDASQLTPMITygtnpGMGMPIDgRIPTPEELPDPAARQALDKALRYMDLRPGQPLLGHKIDVVFLG--------SCTNSRISDLRMAARLL------KGRKIADGVRMMVVPGSQQVKKQAEAEGLHEIFRAAGAEWREAGCSACLGMNDDKVPPGR----------YAVSTSNRNFEGRQGPGART-FLASPLTAVASAIEGAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5CSH5(110-442:473) 3-isopropylmalate dehydratase large subunit n=70 Tax=cellular organisms RepID=LEUC_VARPS  E=3e-32 s/c=0.43 id=30% cov=35%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVVCGDSHTSTHGAFGALAHGIGTSEVEHVMATQTLLGKKAKNMLVKVEGKLPFGCTAKDIVLAIIGKIGTAGGTGYTIEFAGSAIRDLSMEGRMTVCNMAIEAGARAGLVAVDEKTIGYIK--GRPLAPTGV--EWDQAVAYWRTLQSDPDaaFDAVVELDATQIQPQVTWGTSPEMVVDINgRVPDPDKEKDASKRSAIERALVYMGLEPNKAMNDIFIDKVFIG---SCTN-SRIEDMREAAAVVKK---LGQKVAKNVKLAMvVPGSGVVKEQAEREGLDVIFKAAGFEWREPGCSMCLAMNADRLEPGERCASTS----------NRNFEGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P49367(17-619:693) Homoaconitase, mitochondrial n=21 Tax=Dikarya RepID=LYS4_YEAST   E=6e-32 s/c=0.24 id=30% cov=54%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAGRGIGHQIMIE-------------EGYAFPlNMTVASDSHSNTYGGLGSLGTPIVRTDAAAIwATGQ-TWWQIPPVAQVELKGQLPQGVSGKDIIVALCGLFNNDQVLNHAIEFTGDSLNALPIDHRLTIANMTTEWGALSGLFPVDKTLIDWYKnrlqklGTNNhpriNPKTIRALEEKAKIPK----ADKDAHYAKKLIIDLATLTHYVSGPN---------------------------------SVKVSNTVQDLSQQDIKInkAYLVSCTNSRLSDLQSAADVVCPtgdlNKVN---KVAPGVEFYVAAASSEIEADARKSGAWEKLLKAGCIPLPSGCGPCIGLGAGLLEPGEVGISAT----------NRNFKGRMGSKDALAYLA------------SPAVVAASAVLGKISSPAEVL------STSEIP----------FSGVKTEIIENPVVEEEVNAQTEA----PKQSVEI-----LEGFPREFSGELVLCDA-------DNINTDGIYP----------GKYTYQDDVPK-------------EKM-----AQVCMENYDAEFR----TKVHPGD-------------------IVVSGFNFGTGSSREQAA--TALLakGINLVVSGSFGNIFSRNSINNALLTLEIP--------------------------------------------------------------------------
>UniRef50_C1F700(124-459:475) 3-isopropylmalate dehydratase large subunit n=250 Tax=cellular organisms RepID=LEUC_ACIC5  E=7e-32 s/c=0.42 id=28% cov=37%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIVCGDSHTSTHGAFGALAFGIGTSEVEHVMATQCLPQGRPKTFRISVEGELPEGVTAKDIVLGIIGRIGTDGATGYVIEYAGSAIRSLSMEGRMTVCNMSIEAGARAGMIAPDETTFAYLK----DREYSPKGKAWDEAVAAWSElkTDEGATFDRELVIPAIELTPYVTWGTNPGMVIPITDeIPGPETAASEADQRGIER---ALEYMGLKPGTPMEEVAIDVVFIGSCTNSRIEDLRAAA------KVVTGYRVNEKVRAMVVPGSHRVKEQAEREGLDRIFREAGFEWREPGCSMCLGMNPDILTPGERCASTS----------NRNFEGR-QGRGGRTHLVSPMMAAAAAITGH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2KBD7(96-410:418) 3-isopropylmalate dehydratase large subunit n=21 Tax=cellular organisms RepID=LEUC_ELUMP  E=2e-31 s/c=0.44 id=29% cov=33%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIGADSHTCTGGALGAFATGMGSTDVAVGMaLGK-TWLKAPQTFKIEVEGAFKKGVGAKDLILHLIGVIGADGATYKALEFHGSTIRNMEMADRFTLANMAVEAGAKAGLFFTDEKTRAYLAERGRGD-NFKLISA-----------DEGADYEKVIKIDASSLEPTVSCPH---------------TVDNTKTVGELKDIKVNQVF------------------IGTCTNGRIEDLRIAAEILKDK------KVNPGTRTFITPASRDVMLAALKEGLIEIFVKAGASVQTPGCGPCVG--------VHGGILGDGEVCLA--TQNRNFQGRMGNTKGFIYLSSPA-VAAYsALKG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8GY66(108-455:479) 3-isopropylmalate dehydratase large subunit n=15 Tax=Proteobacteria RepID=LEUC_CAUCN  E=7e-30 s/c=0.39 id=27% cov=35%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLRQKKAKNMLVRVDGQLPPGVTGKDVALAVIGEIGTAGGTGYVIEFAGEAIAGLSMEGRMTLCNLTIEGGAKAGLVAPDDKTFAYIQ--GKPAAPKGA--AWDMALSHWKTffTDEDAVFDRTVVIDGSALVPMVTWGTSPEDVIPVtGNVPDPESFATPDKRAAAHRALDYMGLKAGQPISEARIDRVFIG---SCTN-SRIEDMRAAAAVVQEAFLHGRLVAPHVKAMVVPGSGLVKEQAEEEGLDAIFKAAGFDWREPGCSMCLAmNPDKLAPQ----------ERCASTS-NRNFEGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B5EHU2(30-420:427) 3-isopropylmalate dehydratase large subunit n=7 Tax=Bacteria RepID=LEUC_GEOBB  E=1e-29 s/c=0.34 id=28% cov=41%
-------------------------------------------------------------------------------------VMCHEITTPIAIADLMA---RGKDRVFDPTKIK------AVIDH--VTPSKDSKTATQAKMLRDWARRHDIKDFFDIG------------ANGVCHALFPE-------------KGFIRPgNTVIMGDSHTCTHGAFGAFAAGVGTTDLEVGILKGVCAFREPKTIRVNLNGTLPKGVFAKDAILRVIGHLGVNGATDRVIEFGGPVVAQMTMESRMTLCNMAIEAGGTSGICMPDQVTVDYLwpFISGSFGSKEEALAAYS----VWCSD-ADAAYEQVIDLDLSDLAPLC-----------------TFGYKPDQVKSVTEMAGTQVDQVYLG----------------SCTNGRLEDLRVAAQIL------KGKKIASHVRAILSP---ATPQIYKDAvaeGLIQIFMDAGFCVTNPTCGACLGMS--------NGVLAEGEVCAS--TTNRNFMGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8HAC9(128-472:484) 3-isopropylmalate dehydratase large subunit n=491 Tax=cellular organisms RepID=LEUC_ARTCA  E=1e-28 s/c=0.38 id=30% cov=35%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVVCGDSHTSTHGAFGALAMGIGTSEVEHVMATQTLSLKPFKTMAINVEGTLRPGVTAKDIILAVIAKIGTGGGQGYVLEYRGSAIRALSMDARMTICNMSIEAGARAGMVAPDETTYAYMQ--GRPhapegADWDAAVEYWNTLK-----TDDDATFDVEVDLDADTLEPFVTWGTNPGQGVSLSQaVPSPEDFGDENAKAAAERALQYMGLEAGTPMKDIRVDTVFLG---SCTNSRIEDLRAAADII------RGREKDPKVRMLVVPGSARVRLEAEAEGLDRVFKDFGAEWRFAGCSMCLGMN---PDQLEPGER------CASTS-NRNFEGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0WAZ4(122-752:757) Putative uncharacterized protein n=1 Tax=Acidaminococcus sp. D21 RepID=C0WAZ4_9FIRM  E=1e-28 s/c=0.21 id=25% cov=66%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSHTR-YGSLGSLSIGEGGPELAKAMLGKSYALKYPKVVAVFMTGMPKPWVGPMDVILSIIGEVFKNGFVkNCVLEFVGPGVENLSMDFRNGIDTMTTE--STClsSLWTTDAKTEEYFAIHGRPEDYKEM------------KPDDAALYDKVIEVNLDTIEPVIALPFHPSNVYSLKEIiadPKAALSIIDKNAKRTFENNPNVHWNLAGKIHDDGKLYVDQGVIAGCCSGSF-ENLYAVGKMAEY-MNHGVG-------SFNfnvyPASQPIMTALMEAGTIKTLMDYGVRVKSAFCGPCFG-AGDTPANNEFSIRHT----------TRNFPNREGSNPAMNQFSCVALMDSRSIAAT-----------SFNGGKLTSAEDVW---QDITYPKYHFNSQIYENTVYNGFKKAE--KDVEMVYGPdIRDWPDM-----------------TELADDLLLKVASVIHDEVtTTDELIPSGETA----------SYRSNPEKISAFTLIRKDPKYVGRAKtvreFERARLKGDEKTAME-----YFSILEKAGIFvpkDRLMNH--TGIGSVLYA-KRPGDGSAREYAASCQKVLGGFANICIEYaTKRYRSNCVNWGILP--FTYGTDP--IDLQPGEYIYLSNIRNSVEKGltEVEATVISEDGKTRVMKLNLPDVTEAEKQVLLAGSLINF-------
>UniRef50_D2LMX6(109-425:432) Homoaconitate hydratase family protein n=3 Tax=Aciduliprofundum boonei T469 RepID=D2LMX6_9EURY  E=2e-28 s/c=0.41 id=31% cov=33%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGADSHTCTSGALGAFATGMGSTDvAIAFALGK-VWLRVPETHRFYIEGKFPKGVYSKDLILHIIGTIGADGATYKSMEFYGPTIDKMSMESRFTITNMAIEAGGKTGMIAPDATTKKYLEEMGRG-------EKYREIK-----SDDDAWFEKEYEFNVDELEPTVSFPH----------------------------TVDNTRTISEAKKMNIRIDQVYIG---TCTNGRIEDLRVAAKILDGNKVNK--------KTRLivIPASRRVYIQALKEGLLEKFVEAGAAIESPGCGPCVG--------IHKGVLADG---ERVLSTqNRNFKGRMgNPNAEI-YLGSPATAAATAIEGKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B5J8F2(123-414:425) Aconitase family (Aconitate hydratase) n=1 Tax=Octadecabacter antarcticus 307 RepID=B5J8F2_9RHOB  E=9e-26 s/c=0.41 id=28% cov=33%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GYDTHVTNFGAVGAYGVAVLTEVTELLALGS-VWQTVPETVRIELTGRMQQGVSIRDVAQRLLVTLDPELVDDAVIEFGGAGTAGLGIDARYTLCNTPTEIGARSSIVEPDKIVTDYLA--GRCSEPVELLKA-----------DTDARYRAVVKVDLSTCEPQVSLPPRPENVADVSTVAGR----------------------------EIDH-----AYIGSCASGMLTDLRVAAELL------RGRQVNPRVRLFVTPVSQEVASAAAQEGLMEVFIKAGAIITQAGCGVCAGGRiGPVAPG-----------EVSIGTGTRNDPGRLGAHDATLYLASPATVAASAITGKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q9UT74(104-646:721) Homoaconitase, mitochondrial n=9 Tax=Dikarya RepID=LYS4_SCHPO   E=5e-25 s/c=0.22 id=31% cov=54%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAGRGIGHQIMVE-------------QGYAMPGSMaVASDSHSNTYGGVGCLGTPIVRTDAAAIwATGQ-TWWQIPPIARVNLVGQLPKGLSGKDIIVSLCGAFNHDEVLNHAIEFYGEGLNSLSIESRLTIANMTTEWGALSGLFPTDEKLLawyeDRLKFLGPNHPRVNReTLDAIKASPILADEGA--FYAKHLILDLSTLSPAVSGPN---------------------------------SVKVYNSAATLEKKDILIkkAYLVSCTNGRLSDIHDAAETVKGKKVADG--VEFYVGAA----SSEVEAAAQKNGDWQTLIDSGARTLPAGCGPCIGlGTGLLKDG------EVGISAT-----NRNFKGRMGSREALAYLASPAVVAASAIAGKI-----VAPEGFKNAVSLVSAVDIT----------------------DKVNKQTASKSSTEAVDSE--------TAI-----IDGFPSIVAGEIVFCDA-------DNLNTDGIYP----------GRYTYRDDITKEEM------------------AKVCMEN----------------------YD-SEFGKKTKKDDILVSGFNFGTGSSREQAATAILSRGIPLVVGGSFSDIFKRNSINNALLAIQLPD-------------------------------------------------------------------------
>UniRef50_Q5NTF8(7-365:369) Aconitase (Fragment) n=1 Tax=uncultured bacterium RepID=Q5NTF8_9BACT  E=5e-25 s/c=0.33 id=27% cov=38%
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERDGLLADLEAIGATVLANACGPCIG-----QWERSKDITSKPNTI--VNSFNRNFPRR--NDGSANtlsFVTSPDTVIALALAGRLDFDPIIDTI-TAPDGTVVRLE---PPRGEI--LPARGYDSGKNTFIAPPADGSAI-QVVVSPSSDRlqllhaFPaWDGKD-YLELP--------------------VLMKARGKCTTDHIS---------AAGKWL--------------TYRGHLENISGNLFA--GVVNAFTGMAGGG--LDILDGTARPFPEIAKRYSIAGVRWCAVGDQNYGEGSSREHAAMEPRYRGGVVILARSFARIHETNLKKQG-LCATYVCRTRIRTISSVNATPSACSGYRRCQ-KKPVRCVINKPYGTTIEFEALHTF-SAEQVEWFKAGSALNVVRQKL--
>UniRef50_P81291(6-416:424) Isopropylmalate/citramalate isomerase large subunit n=13 Tax=Euryarchaeota RepID=LEUC_METJA  E=1e-24 s/c=0.29 id=28% cov=32%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVGADSHTCTHGAFGAFATGIGSTDMAHVFATGKLWFKVPETIYFNITGDLQPYVTSKDVILSI---IGEVGVDGatyKACQFGGETVKKMSIASRMTMTNMAIEMGGKTGIIEPDEKTIQYVKeamkkhGTERPFEVIK--------------GDEDAEFAEVYEIEADKIEPVFACPHN------VDNVKQ-----------AREVAGKPIDQVF----------------IGSCTNGRLEDLRM-----AIKIIEKHGGIADDVRVVVTPASR--EEYLKalKEGIIEKFLKYGCVVTNPSCSACMGSlYGVLGPG-----------EVCVSTSNRNFRGRQGSLEAEIYLASPITAAACAVKG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A3JVQ2(113-440:459) Isopropylmalate isomerase large subunit n=4 Tax=Rhodobacterales RepID=A3JVQ2_9RHOB  E=2e-24 s/c=0.36 id=27% cov=33%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSHTTTYGAYGALGFGIGTSEVEHVLATQTLRYKRMKTMRVLIEGDTAPGVTAKDIIMKVVQVVGAGGANGFAVEFAGSATQNLDMAGRMTVCNMAVELGARAALIAADEITETALQghsHSGR-----------FTYNGESWHSDLEAVFDKEVTIAGGDIEPLITWGTSPDQSVPITAqvpVASDYVTPKAKAALARSLNYMGLTEGQSAQSIEIDT-----AFIGSCTNSRIEDLREAAKILTGRHVAAG------VEAIVVPGSAMTRLKAEAEGLREIFEAAGFEwRPEAGCSMCL--------AMNDDIAMDGERVAS--STNRNFEGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6XPX3(3-296:319) Putative uncharacterized protein (Fragment) n=1 Tax=Botryotinia fuckeliana B05.10 RepID=A6XPX3_BOTFB  E=4e-24 s/c=0.39 id=28% cov=25%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIGATTSLFPFNDRMYDYLAATKRTEIG-DFARTYAKELK----EDEGAQYDELIEINLSELEPHINGPFTPDLATPISKFSEAVKANNW--------------------PEELKVGL-----IGSCTNSSYED-MSRAASIAEDAMAHGVKAKALF--TVTPGSEQIRATIERDGQLKTFEDFGGMVLANACGPCIGqwDRRDVPKGTANSI---------ISSYNRNFTGRndANPAT-HSFVASPDLVVAMTIAGSLHFNPLTD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8S1K9(121-735:740) Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC BAA-613 RepID=A8S1K9_9CLOT  E=2e-22 s/c=0.18 id=24% cov=66%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPPYTAVIHQY---------MRECAAGGGRM----ILGSDSHTR-YGCLGTMGIGEGGTEIARQALGSTYDIRRPPVIAVKLSGAPVPGVGPMDVALTL------IGAVfdcgfckNKILEVVGDGIANLSMEYRMGIDVMTTETAALSSIWMTDETVREWLAIHGREDAYEKL------------EPTGDALYDGLIEIDLSSMEPMIALPFHPSNVYSIRELCRD-RAYLDGVLESVEKDAYMRSGLTYTLRDKIKNKRLMVqqASIAGCAGGTFDNIAAVADILdGYKISGDGISLGIY------PASQPVFLETMRQGVAERLLLSGVTIRPCICGPCFG---------TVDVPANNTLGIRHVS--RNYYSREGSKTDSGQLSATALMDARSIASTVR------------NGG------LLTAATEMDTVYRKFDyhfeNTIYRgGVYNGFGCPNP---CIHVPKGPN---------IKDWPDFSEMRK-----------HVLLKaaacFEGSITTDELCPSGEASslrsnPEKIAAYTLISKDQE------YVEYAGN-------------IRDALENENTG--TRSVLE-QVCTMLGSEMKDISYGSLLI---SDKIGDGSSREQAASNQKVLGGWANLAieYSTKR-YRSNCISWGLIPLSCKERPDLKK----GDYLLLPDASGKIRMGEEQLEGIILKTGEKVRLSIGEM--TEEERRMLVLGGMINY-------
>UniRef50_A9A5B7(21-416:422) 3-isopropylmalate dehydratase n=6 Tax=Thaumarchaeota RepID=A9A5B7_NITMS  E=6e-22 s/c=0.28 id=27% cov=33%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYVGGDSHTNTTGALGAFACGLGHTDIAYVLLNGQIWFKVPETDYFKLNGKLPDHVMAKDLILKIIGDIGTDGGNYRTMQFGGTGIDEMSVESRLTLCNMTTEAGAKNGIAEADQKVVDYLSSRGATNAQV-------------FKGDDDAQYANVYEYEASEMEPLVAKPFSPE----------------------------NIAVVREAPSVELDK-----SYIGSCTGAKYEDLEAAAKILKGKTVK--------IRTEILPASISIYKRAMENGLLTIFLDAGVTVGPPTCGACCG-------AHMGVLAKNEI---CISTTNRNFPGRMGHVESETYLSSPMVAAASAVTGKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2ABF2(123-720:726) Aconitase family protein n=5 Tax=Bacteria RepID=D2ABF2_SHIF2   E=1e-21 s/c=0.18 id=25% cov=63%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSDSHTR-YGALGTMAVGEGGGELVKQLLNDTWDIDYPGVVAVHLTGKPAPYVGPQDVALAIIGAVFKNGYVkNKVMEFVGPGVSALSTDFRNSVDVMTTETTCLSSVWQTDEEVHNWLALHGRGQDYCQL------------NPQPMAYYDGCISVDLSAIKPMIALPFHPSNVYEIDTLNQNLTDILREIEIESERVAHGKAKLSLLDKVENGRLKVQQGIIAGCSG-GNYENVIAAA----NAL-RGQSCGN--DTfSLAvyPSSQPVFMDLAKKGVVADLIGAGAIIRTAFCGPCFG-AG--DTPINNGLSIRHTT--------RNFPNREGSKPANGQMSAVALMDARSIAAT------------AANGG--YLTsaselDCW---DNVPEYAFDVTP--YKNRvYQGFVKGATQQPLIYGPN--IKDWPE-----------------LGALTDNIVLKVCSKILDEVtTTDELIPSGETSsyRSNPIG---LAGNVSELT-----------EV-----FARIK----QIAGQE----------HIDPL--------QTEIGSMVYAVKP-GDGSAREQAASCQRVIGGLANIAEEYaTKRYRSNVINWGMLPLQMAEVPTFEV-----GDYIYIPGIKAalDNPGTTFKGYVIHEDAPVTEITLYMESLTAEEREIIKAGSLINF-------
>UniRef50_Q94AR8(122-501:509) 3-isopropylmalate dehydratase n=45 Tax=cellular organisms RepID=LEUC_ARATH  E=1e-21 s/c=0.28 id=30% cov=32%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLGTDSHTCTAGAFGQFATGIGNTDAGFVLGTGKILLKVPPTMRFILDGEMPSYLQAKDLIL---QIIGEISVAGatyKTMEFSGTTIESLSMEERMTLCNMVVEAGGKNGVIPPDATTLNYVE--NRTSVPFEPV--YSD-----GNASFVADY----RFDVSKLEPVVAKPHSPDNR----------------------------ALARECKDVKIDR-----VYIGSCTGGKTEDFMAAAKLFH----AAGRKVK--VPTFLVPatqkvwmdvyalpvpgaGGKTCAQIFEEAGCDTPASP--------SCGACLG--GP-----ADTYARLNEPQVCVSTTNRNFPGRMGHKEGQIYLASPYTAAASALTGRV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q8U0C0(84-373:380) 3-isopropylmalate dehydratase large subunit 2 n=4 Tax=Thermococcaceae RepID=LEUC2_PYRFU  E=8e-20 s/c=0.35 id=32% cov=27%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVGADSHTPTLGALGVFAVGMGATDV-AVILGLgKTWFRIPESVGVILEGNPSRYVMATDVILHLLSLLKDYDMNYRAVEFF-----NVP--------------------FSLDER----LTLTNF------VVEANAK-TGIIGEEYTGDGYVKELEIELNSLNPLVAKPHNPANVVPVEEV------------EGTKIDQVF---------------------IGSCTNGRFEQISKAAEIL------EGEKVA--VRTIVGPASMNVYKRMIEEGVARKLIEAGAVILPPGCGPCLGRH-------MGVVGDGEI----VLStTNRNFRGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1B6F4(117-418:426) Homoaconitate hydratase family protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F4_THEAS  E=8e-20 s/c=0.34 id=26% cov=34%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVILGTDSHMNLLGAVGAFATGVGNTDIVASWIQGTLWFRVPETMKVTATGKFQRGVYMRDLLTHLVGTLGADGMFFKAVEFVGDAIERSSLAERITLCSMVTEMSGKVGLIMPNGEVLDWLvRRAGQEvPERVEMIR-----------PDEDAVYSETVAVDVSSLEPLASCPDAPDNVRKVREV--------------------------QGERIDQVH-------IGSCSNGRFEDIRAAYEVL--KA--ANFKVADHVRVIITPATREVMKACAEAGMIQDFLSAGVIFTNPTCSLC-------TAEHYGALPSGD---VGVSTTNRNFIGKV-GKGSHTYLMSPASAMASAVRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B5IBY4(115-406:409) Homoaconitate hydratase family protein n=2 Tax=Aciduliprofundum boonei T469 RepID=B5IBY4_9EURY  E=2e-19 s/c=0.35 id=30% cov=32%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAVGTDSHYNILGAMGVFGQGMGDKDIAFAFKTGKTWFEVPETMKVIVEGKYNFPTVARDLTFAVMRELGPAGALGRSIEYYGDAISSLSIDGRITLASQTTEMGGIIGFTPMDEKLKSFYESKGMNFKAIE--------------ADKEAEYVEEIHIDVNNLEPLMASPPNP---------------CNVHPVSEYEG------MEIDG------------AFIGSCTNGRYEDLVAAAKIL------KGKKLK--VPLTITPTTREIWLRLMKEGIWEIFAEAGAVLTNPGCGGCAeGMPGLIGDEVY-------------LStTNRNYPGKQGP--GKLYLVSPVIAAASAVEGKV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1ICY1(130-523:528) Whole genome shotgun sequence of line PN40024, scaffold_56.assembly12x (Fragment) n=1 Tax=Vitis vinifera RepID=D1ICY1_VITVI  E=5e-19 s/c=0.25 id=30% cov=33%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLGTDSHTCTAGAFGQFATGIGNTDAGFVLGTGKILLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEISVSGATYKSMEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTHKYLE----DKTDVPYEPVYSDEQARFLSEYR---------FDVSKLEPLVAKPHSPDNR----------------------------ALARECKDVKIDR-----VYIGSCTGGKTEDFLAAAKVFH----ASGKKVK--VPTFLVPatqkvwmdvyslpvpgcGGKTCSQIFEEAGCDTPASP--------SCGACLG--GPrdtyarMNEPQANVIVK--LVCLAVwLFGihgevcvsttNRNFPGRMGHKEGQIYLASPYTAAASALTG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C9K7I3(254-754:843) Aconitase family protein n=2 Tax=Alternaria alternata RepID=C9K7I3_ALTAL  E=5e-19 s/c=0.20 id=27% cov=51%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLGSDSHTCSAGAVSALAIGLG---AGDVMAGLAtgeTWFKVPECIRINFTGQPAWYIGGKDVILSVLKQLkRNTYAAERIVEFGGAGAKLLSCDARFAISNMCtvrdpndrPELKPTA-----DDRS------TSRN---LVLLQAFLfptvslnRLSIAAGARYEGASYASTFEIDLGEVEPFIA--------------------------IYPSPDQVCPVAERTGMRF---DGCF----IGACTTTEEDLVL--AALVLEAGLKRGLTL-EKGKRIVVPGSLPIVKNLRALGLLDIYKACGYEQPAPGCSLCLGIGADVAEAGSQWLS----------SQNRNFQNRMgrgavgHICSAATVAAS-------------SFNMTlTDP------------CDLLNDVSETTFKEYLARCKVARGGSESKLAGGKQANNVQYIEPCLLGENARSAE-------GEVPALEAAAVSLDDARLgsinsrIYKLDDYVDTDalpQIIPAPA-CVGSPTDEMLGSHcfELTNPDFRDYV--RSGHRV--------------------------------------------------IVGGRAFGCGSSREEAPRALKGLGVQCVIARSFAFIFGRNMPNIGML-------------------------------------------------------------------------------
>UniRef50_Q8GAX1(4-252:256) Putative aconitase C-terminal domain (Fragment) n=1 Tax=Acidithiobacillus thiooxidans RepID=Q8GAX1_THITH  E=3e-18 s/c=0.39 id=35% cov=27%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLASPETCAACALTGEITdpRDLGLAPIHVDLPGQ--FLVD-------------------DRMVLAPAPEGTEV-------------------EIIRGPNIAKLPAGKAAPAHLAG-EVLIRLEDDITTDHIMPAGAkvlpLRSNLPAISEFVFHMVDE----TFPSR---------------------AKASGGGF---------------------------IVAGHNYGQGSSREHAALAPRYLGVRGVLVQSFARIHLANLINFGILPLTFVHAEDYakvqagDQLGLD---------LSGLTLGKSLML---RDETQGLDIEAMPQLASARDLELILKGGALSWASEQL--
>UniRef50_Q2GXH4(135-368:605) Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2GXH4_CHAGB  E=7e-12 s/c=0.32 id=34% cov=26%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHAWPGTMaVASDSHGTHYGGVGCLGTPVVRTDACSICATDRTWCNVPPIARVRLTGTLPQGVTGKDVIVAL------------------------------------------CGIFKSD--VLK---------------------------PHPDAVYAKQLYLNLSTLSPYVSGP----DTVKVA------TPLHELAPQKIKVDR---------------------AYIVSCTN-SRASDIRAAAKVFRDAADANGGVVP----------KIAGSILVEAGAQPLMA---------GCGPCIGLGTGLLEPGEVDISAS----------NRNFKGRMGSRDAKAYLSSPEAVAASALSG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q05FR0(99-439:456) 3-isopropylmalate dehydratase large subunit n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FR0_CARRP  E=2e-09 s/c=0.20 id=22% cov=27%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTSKDLILFIIKKITSKGGTGYSIEFKGDCIKSLSISEKMTLCNMSIEAGSKISIISPDVKTINFYKK---KIKNIKKFINYLKQIK----SNKKSFYDKTFYYNAKNIYP----------HITWGSNLDTIIELDELVHSDNFKMLKYMNLKSNNSLYKIKIDKVFIG---SCTNSRFEDLLVCSKLLLKLNKKKHKNVIAYVVS----GSENIRLKCEFYGIDKIFKKYDFIWKNSGCSMCLAMN-------EDKLKPGER---CVSTSNRNFVGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P74582(464-809:868) Aconitate hydratase 2 n=388 Tax=cellular organisms RepID=ACON2_SYNY3  E=2e-08 s/c=0.18 id=25% cov=29%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLLPDTVgTGGDSHTRFPLGISFpAG---SGLVAFAAALGvMPLDM--PESVLVKFTGELQPGVTLRDIVNAIPWVAMQQGklTVGKgdKVNVFNgrimemEGLPDLKVEQAFELTDATAERSCSGSTIKLSEETVaEYLRSNvvlmknmiarGYQDArtllrRIAKMEEWLANPSLMSGD-ADAEYADVIEVNLDEIkEPIVAAPNDP-DNVKL---------------MSECAGDVIHEVFIGSCMTNIGHYRAA-AKI-----------LEGAGTV---------KGRLWI----CPPTRMDEQQLREEGIYGIFAAAGARTEMPGCSLCMGN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2UQK1(1-917:917) Aconitate hydratase 1 n=74 Tax=root RepID=B2UQK1_AKKM8   E=0 s/c=1.15 id=54% cov=99%
--------AKSTFiTGAGTPGQFYSLPAlAENGYPRLNRLPVSIRIVLESLLRNCDGLKVTEKDVDNLASWNANNPGSYEIPFTVARIVLQDLTGVPLLVDLAAMRSAVAGLGKDASVIEPLVPVDLVVDHSVQVDWAGCTDALEKNLDIEFQRNAERYEFLKWGQQAFQTFSVVPPSVGIVHQVNLEYLAQGVMEK----DGVYFPDTLVGTDSHTTMINGIGVVGWGVGGIEAEAGMLGQPVTFLVPEVVGVHMTGELREGVTATDLALHVTQMLRSHGVVGKFVEFFGDGAAALPLADRATVANMAPEYGATMGFFPMDERCSDYLRQTGRSEEAITTYENYFKAQNLWGMPRNgDLDYTDQLELDLSAVEPAVSGPRRPQDHIRLNSIRDSFRklvsmpvaeggygkkESPEVTVSMHSPAGVPVPVDGFSQEAKLKDGSILIAAITSCTNTSNPGLMLAAGLLAKKAVERGLNVPPHVKTSIAPGSRIASDYFATNSLQESLDALGFETVGYGCTTCIGNSGPLNPELEQAVRDNDIVAASVLSGNRNFEARIHASIKTNFLMSPPLVVAFALAGRVDIDFQTEPLGTDRSGNPVFLKDIWPSSGEIAEaVAKSRNPEAYRELYTITPDKNPRWAAVYAPEGSVFQWNEQSTYIQDPPFFSGFNGQPRTLADITDARPLGIFGDSVTTDHISPAGAIRETGPAGLYLQGMGVDRKDFNSFGSRRGNDRVMTRGTFANVRIKNLMVNGTEGGYTLYFgsrsvpaPDKEIIPaagtpafIYDAAMAYAQDGVPLIVIGGEDYGMGSSRDWAAKGTNLLGVKAVITKSFERIHRSNLIGMGVLPLNFANKADYDRITPLKDATFSILGLNNgIAPRQQVTLRVQPADAEAFDVPVIVRIDTPIEKEYYLAGGILQYVLTQILR
>UniRef50_C1YTQ9(17-930:935) Aconitase A n=1 Tax=Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 RepID=C1YTQ9_NOCDA  E=0 s/c=1.04 id=48% cov=98%
------------LNAAGSEFRYVALDRLLTPD-ELDRAPYTVRVLVENVARRA------PEALPAVLARVRSGRGDCEVPFHPNRMMLHDTTCLPTLTDLAALRDTVTELGGDAADVNPVIATDLVVDHSVIAEAHGSVAAFARNLDIDFRRNAERYEFVKWAERSVRGFRVVPPGRGIIHQVNMETLARVVWREdGGDGPDLLHPDVLVATDSHTPMINAIGVLGWGVGGLQAQAAMLGEPVMLNFPEVVGVRLTGGLRRGVTATDLALTLTELLRATGVVDAFVEFCGPGIDGLSWSARAAVANMAPEYGTTCAYFPYDREVRDYLLLTGREDGHVEAVDAYMRAQGLVRGADsPEPRFDRLVEFDLGAVEPCLAGPHRPDQRVPLSRVPASFLETASAPESVPAPDTVAGASTDAGPaaasdlnsapdpdpdpvpaprpgtdgasgaatgedvfGEPLPRGPVGIAAITSCTNTANPALMIQAGLLAARAMERGLRVKPWVKTTLSPGSRVVVGYLEKAGLMEPLEAAGFHTVGFGCMTCIGNSGPLVPELE-GLAGEGLEAAAVLSGNRNFPGRVNPRVSHAYLASPPLVVAYALAGTVLHDFAAEPLGHDRDGNPVHLADLWPDDEEVARVAEKaVDPQAFRENAAEVWEGTEQWRALDAAGSTHFPWNEHSTYIRRPPYLTGVRPEPGSEVRVEDARVLLWLGDHVTTDHISPAGAIPRDSLAGAYLRERGTEPRDLNQYSTRRSNPEVMLRGAFTNPAVANLLLPEGErgrGGHARVLDGSRVEPVFHAAATYREAGVDLVVLAGRSYGTGSSRDVAAKVQALLGVRAVIAESFERIHRSNLIGMGVLPLLFPEGSTAADLGLDGGERLTvLGLGGIGVGVTPLVLRVTGADGSAREHTVLLRLDSGHEVAYLRHGGTMPYVARRF--
>UniRef50_B2SNM3(1-859:863) 2-methylisocitrate dehydratase, Fe/S-dependent n=316 Tax=cellular organisms RepID=B2SNM3_XANOP  E=0 s/c=1.08 id=47% cov=95%
----------------GTSLDYFDARAAIDALqpGAYAGLPYTARVHAENLVRRAE-----PQLLEAYLRQLIERKRDLDFPWFPARVVCHDILGQTALVDLAGLRDAIAEQGGDPAQVNPVVPVQLIVDHSLAVEYAGfDKQAFAKNRSVEDRRNADRFHFIEWTKRAFENMEVIPPGNGIMHQINLEKMSPVIYTL----DGVAFPDTCVGTDSHTPHVDALGVIAVGVGGLEAENVMLGRASWMRLPDIIGVELTGRPAPGITATDIVLALTEFLRAQRVVGAYLEFYGDGARALTIGDRATISNMTPEFGATAAMFYIDQQTIDYLRLTGREDAQVALVETYARHTGLWADDMATAHYERVLQFDLASVVRNMAGPSNPHKRVATTELAQRGIAGTWEAVPG-----------------QMPDGAVIIAAITSCTNTSNPRNVIAAGLLARNANARGLTRKPWVKSSLAPGSKAVQLYLEEAGLLSELEQLGFGIVAFACTTCNGMSGALDPVIQQQIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVIAYAIAGTVRFDIEKDVLGIDAAGVPVTLKDLWPSDAEIDAVVaRSVRPEHFRSVYDPMFKRS-VGQGTNV--NPLYDWRPASTYIRRPPYWEG---ALAGTRTLRGMRPLAVLGDNITTDHVSPSNAIMAGSAAGEYLAHMGVPEEDFNSYATHRGDHLTAQRATFANPTLINEMVvvdgQVNAGSLARLEPEGQVLRMWEAIETYMTRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEVIVAEGFERIHRTNLIGMGVLPLEFKPGTDRKTLGIDGSETFDVVG--ERRPGATLTLSIHRRDGDQLQVPVTCRLDTAEEVSIYEAGGVLQRFAQDFLE
>UniRef50_Q0CTP7(31-756:1095) Aconitate hydratase, mitochondrial n=1 Tax=Aspergillus terreus NIH2624 RepID=Q0CTP7_ASPTN  E=1e-167 s/c=0.82 id=26% cov=78%
-------------EAAGASNRMPPYPKILRNLEEVRRVLGSSRtlTLAEKIL--YSHLANPEDSLLTGTNNGRDIRGKANLKLKPDRVAMQDASAQMALLQFMS-------CGLPSTAV----PASIHCDHMIVGERGADTD-----LPASIKGNSEVFDFLESAAKRY-GIEFWPPGAGIIHQSVLE--------------NYAAPGlMMLGTDSHTPNAGGLGAIAIGVGGADAVDALVDAPWELKLPRssVCVWRAVSTAGP---PQDIILHLAGQLTVRGGTGFVIEYHGPGVETLSCTGQATICNMGAEVGATTSVFPFSPSMVPYLQATHRGDVAEAAARIASSGPKNLLRADDGAEYDQLITINLSTLEPHINGPFTPDLSVPLSRFADTVREKGWPETFGA-------------------------GLIGSCTNSSYED-MTRAEDLVKQAQAAGLTPKAD--FFITPGSEQIRATLDRDQTLSTFSEAGGTVLANACGPCIGQW------KRTDGVAKGEDNAIFTSYNRNFPGRNdGNRRTMNFLASPELVTALTYSGETTFNPMTDSI-TTPSGESFRFQ----------------PPSGSALPDDGFADGNPSFQPTAAVPDPTCEVKVSPTSDRLA---LLEPFAPFPKDNLRGLKVLYKVKGQCTTDTIS---------AAGPWLKYKGHLPNI----------------SANTLIGAVNAATGETN---VAYDEQGQTYSIPDLAAKWKSQGVEWLVVAEENYGEGSAREHAALQPRYLGGRVIVAKSFARIHETNLKKQGVVPLTFANPADYD--------------------------------------------------------------------
>UniRef50_UPI0001792BEA(39-652:658) PREDICTED: similar to ACOnitase family member (aco-2) n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792BEA  E=1e-118 s/c=0.70 id=29% cov=62%
---------------------------------------------------------------------------------RPDRVAMQDATAQMAMLQFIS-------SGLPKVAV----PSTIHCDHLIEAQTGGVED-----LKRAKDMNEEVYSFLKSAGAKY-GVGFWHPGSGIIHQIILE--------------NYAFPGLLmIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKSPN-------PPG-------------------------------------SAFVICSVC---------------------SKGRSE-----------------------------------------------------------------------------------------------GLIGSCTNSSYED-MSRCATIAKEALAHGRKSK--IPFNVTPGSEQIRATIERDGIAQTLREFGGTVLANACGPCIGQWD------RKDVKKGEKNTI-VSSYNRNFTGRNDANAAtHAFVTSPELVTALAIEARLDFDPTVDSI-KGADGKEFKLSN--PFGDELP--ARGFDPG--QDTYQAPPADG---------SGLSVVVDPKSNRLQLLEPFKVWDG-----KDLEGLTILIKVKGKCTTDHIS---------AAGPWLKYRGHLENISN------------------NMLLTATNAENNEMNKVKNQDTGEWGAVPDTARAYKAKGISWVVFGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLALTFSDAKDYD--KVQPSDKVSLVGLNQFTPGKPLKCILSHADGSSDEILLNHTF-NEQQIQWFKSGSALNRM------
>UniRef50_B8E2Q9(15-411:418) 3-isopropylmalate dehydratase n=2 Tax=Dictyoglomus RepID=B8E2Q9_DICTD  E=1e-105 s/c=0.97 id=31% cov=35%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEGVCHQVFME-------------RGLATPGSLViGADSHTCTYGVLNCFSTGVGSSELAAAMYTGKLWFKVPSTVKIILNGKLSKGVVSKDVILFLAGYFKADGLTYKAIEFDGEVINNLSIDGRATITNMVVEMGAKAGIMPFDEKTKEFFKSIGLPQEK-------------GVEADPDAEYEAVYEFNLSNLEPQVALPHTVDNVYPIS---------------------------------QIENIKIHEAFIGTCTNGRLEDLRLAASIL------KGRKVAKNVKMIVTPASKRIFMQAMKEGLVDIFLEAGAIVTNPGCGPCVGTHQGVPADGENIIS----------TANRNFKGRMGNNKAFIYLASPLTVAASAVLGKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8M422(239-784:1362) Aconitase family protein n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8M422_TALSN  E=1e-103 s/c=0.70 id=26% cov=61%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQPGMLViGSDSHTCSSGALGCLAIGLGAADVTLPLVTGETWFKVPESVNVRLIGSPKPGIGGKDIILYILQQLKRNTVAsERIVEYTGPGLQYLTSDARFAICNMTAELGGITGIFVPDGTTLDFVQ---------KRLHPRHKTASIFLKPDEDAQYAETYEINLGNVHSFIAKHPKPDDVVPVAEC---------------------------------ENMPVDGCFIGACTTT-EEELILGA-LVLEQGLKSGLKPVNKGNRRVVPGSLPIQRRLRELGLLDIYEACGYKIGVPGCSYCVGMSADQAKPGEVWLS----------SQNRNFENRMG-KGSFAYLASAATVAASSFEMKVKDPhdlLCRVNLARWNSLKAIKKTSGLNGQQNLQVLVNYVEPNGFGNPSS------------IDQSSLRAEYVAASTEVRvnNPGEPINVKAEENVLKGK-----IQKLGNYIDTDALAPAN---------------------------------------FLVESKTNEVLGTHCLEYTHPDFRQKVKDGFN------------IVVAGTGFGCGSSREQAVMALLGCGVQCVIAKSFAFIFQRNMPNLGLLGITISDESFYDA-ATDGTE-ISINLSNN-------EVVLGKR---QVKFEL-----SQMEKELFDHGGI----------
>UniRef50_P81291(7-418:424) Isopropylmalate/citramalate isomerase large subunit n=13 Tax=Euryarchaeota RepID=LEUC_METJA  E=4e-97 s/c=0.87 id=24% cov=34%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVGADSHTCTHGAFGAFATGIGSTDMAHVFATGKLWFKVPETIYFNITGDLQPYVTSKDVILSIIGEVGVDGATYKACQFGGETVKKMSIASRMTMTNMAIEMGGKTGIIEPDEKTIQYVKEAMKKHGTERPFE--------VIKGDEDAEFAEVYEIEADKIEPVFACPHNVDNVKQAREVAGK---------------------------------PIDQVFIGSCTNGRLEDLRMAIKII-----EKHGGIADDVRVVVTPASREEYLKALKEGIIEKFLKYGCVVTNPSCSACMGSLYGVLGPGE----------VCVSTSNRNFRGRQGSLEAEIYLASPITAAACAVKG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9A043(6-398:431) 3-isopropylmalate dehydratase large subunit n=13 Tax=Bacteria RepID=LEUC_DESOH  E=2e-96 s/c=0.91 id=27% cov=31%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIIMGDSHTCTYGAFGAFAAGVGTTDLEVGILKGVCALNYPSTIKVVLNGKLSPGVYAKDVILAVIAELGVNGATNRVIEFTGPCVDAMSMEARMTLCNMAIEAGGTCGICYPDKTTVAYLweFIKGEYPSRQAALKAFKKLV-----SDPDADYDRVLEMDISDLSPRVTYGYKPDCVKPVAEMEGT---------------------------------PIDQVYIGSCTNGRLEDLRVAAKVL------KGKKVHPSVRGIVSPATPTVFQAALEEGLIATFMAAGFCVTNPTCGACLGMSNGVLAPGE----------VCLSTTNRNFNGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5EE69(54-411:415) 3-isopropylmalate dehydratase large subunit 1 n=9 Tax=Bacteria RepID=C5EE69_9FIRM  E=2e-95 s/c=0.99 id=29% cov=35%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKGVCHQIMMEHY-------------VCSGELIFGADSHTCTYGALGAFGTGVGCTDFLYGMVTGTSWVLVPETVKFNLVGRLQEGVYPRDLMLTIIGEIGANGCNYQVMEFTGEGAKTLSINDRMVLCNLAVEAGAKTGIFEADEAAVRYLRERGREPKAV-------------YTSDPDAVYAREYTFDLSQIQPVVARPDFVDDVVPAKDVCGV---------------------------------KIDEAFLGSCNNGRIDELRVGAAIL------KGKKVADSVRFLVVPASLEVYRQALKEGLIDIFMESGAIVMNPNCSVCWGSCQGVIGENEVLIS----------TGTRNFKGRAGHPSSKVYLGSAATVTASAIAGEI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A5WGT5(32-471:478) 3-isopropylmalate dehydratase large subunit n=270 Tax=cellular organisms RepID=LEUC_PSYWF  E=4e-94 s/c=0.79 id=29% cov=37%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVVCGDSHTATHGALGCLAHGIGTSEVEHVLATQCLVQKKSKNMLIRVNGELGAGVTAKDVVLAIIAKIGTAGGTGYAIEFAGEVFENMSMEGRMTVCNMAIEAGARVGMVGVDETTIEYVK--GRPFAPTG--EQWDQAVEYWntLHSDEGAHFDAIVELDASDIAPQVSWGTSPEMVVDVTQyVPTLAQAKDEVQAEAWERAYQYMGLEQGQPITDIKLDRI---FIGSCTNSRIEDLRSAASVI------KGRKVAANVKeAIVVAGSGQVKQQAEQEGLDKLFIEAGFEWREPGCSMCLAMNADKLEPQEHCAS----------TSNRNFEGRQGNGGRT-HLVSPAMAAAAALAGH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5BFR8(6-414:421) Homoaconitate hydratase family protein, large subunit n=3 Tax=Bacteria RepID=C5BFR8_EDWI9  E=2e-92 s/c=0.84 id=29% cov=34%
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGTLIlGTDSHTCMGGALGAFATGVGSTEMVGILATGKTWLKVPESQRVEWSGPLPPGVMAKDIALKTIGHIGHAGATYQAVEFCGSTFADMPIDQRMAIANMAVEMGAKAGLMSVDALTEAYLAAQGIGRDAYTV-----------YPPDDDAIYVRQLRFAAPALAPQIACPHNVDNVTDIDNVAGT---------------------------------RIDQAYLGSCTGGRYSDLAAAADLL------RGKRIARGVRLLVSPASQQIWQQASRSGILSQLAEAGATILAPTCGVCVGLHSGLLAGGENCISA----------SNRNFIGRMGSRDANIYLASPLSVAAAALTGSI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6TSE5(5-415:425) 3-isopropylmalate dehydratase n=4 Tax=Clostridiales RepID=A6TSE5_ALKMQ  E=4e-92 s/c=0.83 id=27% cov=36%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVCHQVMVE-------------EGLVWPGMiLVATDSHTTTHGAFGALGTGVGATDLATIMLTGELWFKVPEVIKIEINGKLKSGVMAKDVILHILSKLGTDAAVYKAIEYTGETVAEMSIAERMVICNMAVEMGAKTSYIQPDEKIIAYVKeRTGKTFEILK--------------TDDDYEYAASYTFNVEDLKPQVALPHSVDNGVDID---------------------------------KIKEVKVDQVFIGTCTGGRLEDIEVAARIIKNN------KIHRDTRLLVIPASKEVLEKAIEKGYMTTLIKAGATFTSPGCGPCLGTHQGLLAPGE----------VCATTSSRNFPGRMGSTEADIYLVSPATAAAIAITGKI-----TDPRGY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q8PZT3(5-386:391) 3-isopropylmalate dehydratase large subunit 1 n=7 Tax=cellular organisms RepID=LEUC1_METMA  E=2e-91 s/c=0.89 id=30% cov=36%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------EQSIPNFYEI--GEGICHQVLPE-------------NGFALPGkLLVGADSHSCTYGAFGAFATGVGATDMAEIFATGKLWFKVPESFRMTVEGSLDKHVYAKDLTLYLIGKTGIAGATYKAVEFYGQAISELSVAGRMTLCNMAIEMGAKTGIVPPDEKTFDFLK--NRAVAPYEPVY-----------SDPDASYLKEFVYDAGDIEPQVACPHQVDNVKPVGEVEGTH---------------------------------VDQVFIGTCTNGRLEDLEVAASVL------KGKKV--TVRTIIIPASRSTLLAAIKNGTMEILLKAGVTLATPGCGPCLGAHQGVLGEGE----------VCVSTANRNFKGRMG-KDGFIYLASPATAAASALTGEI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C4Z1K0(13-410:413) 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit n=9 Tax=Bacteria RepID=C4Z1K0_EUBE2  E=1e-90 s/c=0.85 id=29% cov=33%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIAFGTDSHTTTYGCVGAFSSGIGYTEMASVLGTGKMWVKVPQTIKVTVNGKLPENVRSKDIILRLIGDLGADGATYQALEFTGSTIDEMSVASRMTMSNMAIEAGAKCALFTPDEKTAEY--------CNVELTDELKDLKG-----DADAVYAREITYNAEDLVPVIACPSQVDNIKPVTELAGT---------------------------------AVDQVFIGSCTNGRLEDLQCAAAIL------KGKKVAPFVKLIVTPASRKIYKEALADGTLETLVEAGAIVTHPGCGLCCGRTGGILTDGE----------VVVATNNRNFLGRMGTSKVKIFLASPATAAASAIAGKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8Z5S0(25-447:461) 3-isopropylmalate dehydratase large subunit n=3 Tax=Bacteria RepID=A8Z5S0_SULMW  E=2e-89 s/c=0.79 id=26% cov=34%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIVCGDSHTSTHGAFGCIAFGIGTSQVAMVMATQCLLQTKPKQMRIKLEGKLNLGVTAKDIILYILSKLGPDGGTGYFIEYSGSVFKRMNMEERMTVCNMSIEMGARGGMIEPDSTTLKYLKQKIFSPK-----EKELKKICKNLKTDKKALFDKEYKFNSDNIYPMITYGTNPSMCINISD-----------PIGSKKIQIKSLKYMGLKEGEYLLGLKINYVFIGSCTNSRIEDIRLVSKLI------KNKKKADNVYVMVVPGSKQVYKKIINSGIDLILLNAGFELRKPGCSACLGMNEDKIPYGEYCLS----------TSNRNFEGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5EVU7(8-414:418) 3-isopropylmalate dehydratase large subunit 1 n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EVU7_9FIRM  E=2e-87 s/c=0.80 id=27% cov=33%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGTDSHCCHYGVLNAFSTGIGASEEAVVLASDKCWFKVPETIRVEFTGALNPMVTSKDLILVLIQELTQAGAIYQCLEFGGDTLKELSVDDRAVICNMAVEAGAKGAIMPYDEVLEQWLADRGMEC-------------NGGVAPDADACYARQMVIDVSAIAPMVAIPPDIDQVVPVDS---------------------------------IGKQKVHEVVIGGCTNGRYTDFAQAADIL------RGRKIAPGVRLVIAPASREIAGKMLETGVYRDLLMAGATILPPCCGPCTGITGGL-------IGDNEVVFA---TANRNMPGRMGSQKGKVFIGSPVVAAYSALAG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C7LK14(25-456:469) 3-isopropylmalate dehydratase large subunit n=1 Tax=Candidatus Sulcia muelleri SMDSEM RepID=C7LK14_SULMS  E=3e-86 s/c=0.75 id=26% cov=38%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIVCGDSHTSTHGAFGCIAFGIGTSQVAMVMATQCLLQSKPKQMRIKLEGNLNLGVTAKDIILYIISKLGPDGGTGYFIEYSGSVFKKMNMEERMTVCNMSIEMGARGGMIEPDTTTLKYLYYKIFSPKKKELNSFKKKCKNL--KTDKKASFDKEYKFNSSNIYPMITYGTNPSMGIKISD-----SIPKENNFEKRNIKIKSLKYMGLKEGESLLGLRINYIFIGSCTNSRIEDIK------LISKIIKNKKKAENVSVLVVPGSKQVYKQILNKKIDLILLNAGFELRLPGCSACLGMNEDKIPSGEYCLS----------TSNRNFEGRQGKGART-LLASPLVAAITALEGKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1L3C3(1-377:384) Homoaconitate hydratase family protein n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C3_KORCO  E=1e-85 s/c=0.85 id=29% cov=33%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVIVGTDSHMPTLGALGTFSVGIGATEMAAALIMGKLWFRVPETILVKLDGSLPEMVFAKDIILKLISMIGVDGANYKALEFNGSILKVMEMDERFVLTNMSVEAGAKTAIIPVDDVTLSYLNGRLRRAPRPEY--------------SDDGSHSDEISIDVSSLEPLVAIPHSPANVKPASEV----------------------------------DAEIDQAFIGSCTGGRLKDLEVAARIL------RGRRVKEGVRLIVIPASRRIYLEALRRGIIDILIESGATIGPPSCGPCLGAHLGVLAEGE----------VAISTSNRNFRGRMGHPESRVYLASAATVAASAVEGRI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q1LAU9(20-433:440) 3-isopropylmalate dehydratase, large subunit n=11 Tax=Burkholderiales RepID=Q1LAU9_RALME  E=6e-84 s/c=0.76 id=26% cov=34%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FIVGGDSHSPTGGAFGAYMFGIGATEMAGVLATGEIWLRVPNTIRVEWQGTLSDGVCAKDIMLFLCATLGMAGGRYEVIEYTGSTVKTLSMQERMTLTNMSTELGAQTALIAPDATTMAWLADAGVDAATLAAIEPRQ------WRSDADAPVLATHRFDAGTLVPQVAAPHSPANSGPVDQAAGA---------------------------------PIEIAYLGACTGAKLEDLRMAARVL------RGRKVAPGVSLKVAPASLRDQQQAATEGTLGVLMDAGAELLPNACNACAGYGATRFPAGSRAIA----------STARNFPGRMGDAGSAVWLASPMTVAASAATG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0CU43(3-412:418) Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme DSM 15981 RepID=C0CU43_9CLOT  E=6e-82 s/c=0.75 id=26% cov=33%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSHTTVHGAFGAFATGCGSTDMVAVTRYGKTWIKVPETFRINVNGALPQGVYAKDIMLKLAGIIQSDQAIYKALEFRGDTIHALDMAGRLTITSMGVDVGAKAAIMETDEHTREFLKKFGREQDYREI------------RGDEEANYERVIDIDAAALEPMVAKPHYVHNV---------------------------------DLAKNCADQKVDMVFIGSCTNGRTEDLHVAADIL------RGKKVAKGLRLLVIPNSAAVYKECMQDGTLLALAEAGAMIEAPNCGPCMG--------VHQGIPADNEVVVA--TQNRNFKGRMGNPTASIYLSSPATAAATALRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9G0G3(216-659:662) 3-isopropylmalate dehydratase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9G0G3_SORC5  E=9e-82 s/c=0.69 id=31% cov=35%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTDSHTCMAGALGCFAFGVGSTDMANAWLTRDVRVAVPQSVRFNLIGRLGPGVTAKDVMLFLLSRpfWKTGQGIGKVLEFAGDGVRAMGLDERATLTNMAVEAGGFTGIIEADEEIVRYLV------EQRGLAAEDVRARIV--RADPGAEYMATFDVDLASVEPMVATPGDPRNGVPLRSLDEAAGGPV----------------------------KIDIAYGGSCTGGKKADMDMYASVL-RQAVERGKRVADGVHLYIQFGSQDIRRYAEAKGYLEIFEKAGAELVDPSCGACIKAGPGVSDRKEQ---------VTVSAINRNFPGRSGP--GQVYLASPLIVAASAIAGKIAF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0LGR1(225-649:659) Aconitate hydratase domain protein n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LGR1_HALO1  E=2e-81 s/c=0.72 id=28% cov=35%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFIQATDSHTCMGGASGALSWGVGATEYAALIYWGFTPISVPESIRFELTGSLPPGVTAKDVMLHILDTYaKREDTLNRVMEFGGEGLFALSPDERATLANMATECSARGAVMECDDTMLEWIASR-REDVSAAALKSKAVA------PDPGASYAgGVHVIDLAEIAPMVATPGDPDRGIA-------------------------SDPKNGARISGLDQVAIDIAYGGSCTAGKRDDIDFYAKVM-EEAERAGKRVAEGVSFYLQFGSREVAEYARERGYLGLFERTGVEIIEPGCGACIGCGPGVSTQPDQ---------VTVSAINRNYKGRSGP--GKLYLASPLTVAASAVVGRI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0Y374(1-241:572) Aconitate hydratase 1 n=1 Tax=Burkholderia pseudomallei Pakistan 9 RepID=C0Y374_BURPS  E=3e-75 s/c=1.19 id=55% cov=27%
MAHNLHKTLKE-FDSGSGKGKFYSLPKLGKELKtKIERLPVSIRIVLESVLRNYDGKKITEEHIEQLANWKPNAKRVDEIPFVVSRVVLQDFTGVPLLADIAAMRGVAKRAGKNPKKIEPLVPVDLVVDHSVQIDYFRQKDALDLNMKLEFQRNNERYQFMKWGMQAFDTFKVVPPGVGIVHQVNLEYLARGVHKKKDDGDTVYYPDTLVGTDSHTTMINGIGVVGWGVGGIEAEAGMLGQP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q4YCZ3(31-230:269) Putative uncharacterized protein n=1 Tax=Plasmodium berghei RepID=Q4YCZ3_PLABE  E=2e-72 s/c=1.38 id=51% cov=22%
-------------------YHYYDLNELNDS--RIKSLPYSIRILLESAIRNCDNLKVTEENVKTILAWKENCKKKKEIPFMPTRVLLQDLTGVPCVVDLATMRDTAEFLGGDANKINPLIPVDLVIDHSVQVDYSRSSKAKEYNEKREFERNLERFKFLKWGMNSFENMLILPPGSRIVHQINLEYLAHCVFENKNN--NLIYPVS--------TMINGLGVLGWG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q6KZ03(32-401:407) 3-isopropylmalate dehydratase large subunit n=1 Tax=Picrophilus torridus RepID=Q6KZ03_PICTO  E=6e-63 s/c=0.66 id=26% cov=32%
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSHTVNTGAYNSLGRGLGTPEIMSVIATGRTWFIVGETINVVFKNYLKSNVSAKDVFFYMAKTIGSIP--NKNIEFSGN-LKSLTIDDRASISTMCAEMNVEFALFPNDDVLRAYM--SNRSLYNVV----------------SDGDYSDQYEIDLNEVQSMVARP------------------------------GKIIDNIVNAGDEKTE---ITQAVIGSCANGRLSDIRDAARIL------KNKKINKNVRLIVTPASMEIYKRALELGYIKDIIDAGGIVTNPTCGACLGGHMGIASDNDVIIS----------STTRNFQGRMGSPGARIYLGSAATVAASALNG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6RGM3(469-891:917) Aconitate hydratase 2 n=1 Tax=Campylobacter showae RM3277 RepID=C6RGM3_9PROT  E=2e-42 s/c=0.42 id=27% cov=29%
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDTVgTGGDSHTRF--PIGVSFPAGSGLVAFAAVS-GAMPLNMPESVLVRFSGRLQKGVTLRDLVnaipyyaikrglLTVEKKGKKNVFAGKILEI--EGLENLKVEQAFELSDASAERSaAACAVNLSIESVAEYVRsnvalieamieagyeSRASLERRAAKMREWLAAPELLR-ADKNARYAEVIEINLDEItEPILACPNDPDDVATLSEVLADSSRP----------------------------HKIDEVFVGSCmTNIGHYRALGEA--------LRGLGMLP-TRLWIAPPTKMDQALLEKEGYYDIFRAVGARTEVPGCSLCMGN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9EQ29(119-391:660) 3-isopropylmalate dehydratase large subunit n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9EQ29_SORC5  E=2e-33 s/c=0.54 id=25% cov=23%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VWLRPPRSVQIHLSGRVRPFVCARDVALELLRR-NLDEVVRRiegehhapvILEFAGPSARLLSVGDRAVLCGIAPQVGAAAALFVSDEKTEVFLRDQRRSKAHRALV------------PDPGAPCEEVVSIDLGTVDPLL-------------------MDEEGVVRPVRDLAGKPVAQVVLGGDSGVTLRD-----------------MLAAALLLKS-----KRVPSRLDLLVAPPSRQVLEVLAQSGALVDLVATGARIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0XJF8(1-866:877) Aconitate hydratase n=4 Tax=Lactobacillus RepID=C0XJF8_LACHI   E=0 s/c=1.15 id=53% cov=97%
----MNKSYRQQLNLSGGSYRFYNIDVYLRDHGqDVETLPYSIRILLEEALRHADREPEREQVLSAFNDW--DHQHDKDIPHQPERVILQDFTGVPALVDLAAMRDAVAKRGGNVSSINPEVPVHLVIDHSVQVDHSGNDEAFSYNIQQEFKRNSERYTFLKWAQNSFENLTVIPPGTGIIHQVNLEYLADVIHAKQLTDGSYeAFPDTLVGTDSHTTMINGLGVLGWGVGGIEAESSMLGEATYMPMPKVVGVKLTGKLGEGITATDLALALTHLLREHNVVGKFVEFYGEGTQSLPLAYRATIANMAPEYGATCGFFPIDQQTINYLKLTNRSDEQIALVENYAKANHLFYNEKAVRHYSEDELLDLASVQSSLAGPNRPQDTVYLKDMPKQFDDRREMP---------DYPVEVDGKQFNIRVGSLGIAAITSCTNTSNPQVLLAAGLIAKKAVELGLKVPDYVKTSLAPGSRVVTQYLAASGLQPYLDKLGFNLVGYGCTTCIGNSGQLKENLQTRLTKDPYPIAAVESGNRNFEGRVNPLIKDTYLASPPLVVIHALAGTCDIDLTTQPVGTSKNGSPVYLKDLWPKDVEVAQLSQKyLKPKEFQKNYQSILNQNATWDALPAPESETYQWDDDSTYIASPPFFDN----EAGSKHLTGLRVLAKLGDSITTDHISPAGYIGSQTPAGRYLKSKGIAIKDFNSYGSRRGNHEVMMRGTLANIRLGNQLTPDKTGGFTRYLPTNEETTIFEAAQQYQADHTGLVVLAGKDYGMGSSRDWAAKGVKLLGVKAIIAESFERIHRANLAMMGVVPLQYQPGQTAESLGLDGTETFSIAL------DGKVAHVIAKKDGGQTKFDTIIRFDTPVDWTYYKDGGIMPMIVSN---
>UniRef50_C5K5D0(1-752:753) Aconitase, putative n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5K5D0_9ALVE  E=0 s/c=1.15 id=53% cov=82%
----------------DSGHAFYDLNEL--HDERAKKLPLSIRILLESAVRNCDEFEVKSSDVENILNWSETSKNQTEIPFKPARVILQDFTGVPAVVDFAAMRDAMDRLGGDPAKINPLVPVDLVIDHSVMVDYSRSPEALEKNQELEFQRNGERFAFLKWGAEAFDNSNIVPPGSGIVHQVNLEYLARVVMNATEEGA-VLYPDSLVGTDSHTTMIDGLGVAGWGVGGIEAEAVMLGQPISMVLPEVVGFRLTDRLPVTATATDLVLTCTNMLRKRGVVGKFVEFHGPGCATLSLADRATIANMAPEYGGTMGFFGVDQKSLDYLLQTGRPKHVVELIEKYLKANGLFQDYSEDREYSGELmQLDLSTVVPCVSGPKRPHDRVAVTDLPKDFTDGLSTPX---------------------------------------------------------------------------------------------------------------------------------------EGRVHPLTRGNYLASPPLVVAYALAGRVTIDFEKDPLGADPEGKPVFLRDIWPSSEEVAAVERScVLPEMFTENYKKVLHANKRWTQLAAPSGKLFAWAEGSTYITNPPFFKTTEIDPSPIESIENAYCLLNVGDSITTDHISPAGKITANSPAGRYLMENGVQPPDFNSYGSRRGNYLVLARGTFANIRLINKLMDGEVGPKTEYVPTGEKMFVYDAAEKYMKEGHSLIILAGAEYGSGSSRDWAAKGPALQGVRAVIAKSYERIHRSNLVGMGILPLQFPQGVDADSLGLDGREQFSINlNHGDLSVGQKITVRTTSP--KTPSFDAIVRLDTEVELTYFKHGGILQYVLRRL--
>UniRef50_A4FHT3(29-705:711) Aconitate hydratase 1 n=2 Tax=Actinomycetales RepID=A4FHT3_SACEN   E=0 s/c=1.06 id=49% cov=75%
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSHTPMVNSIGVLGWGVGGLQAQAAMVGEPTAIRFPTVVGVRLTGRLRSGVTATDLALTVTELLRAHGVVDKFVEFTGPGATGLGWAARAAVSNMAPEYGATCAFFPFDDEAMSYLELTARSPEQRAVVAAYLRAQGLYRRAgDPVPRYDEEVALDLDAIEPSLAGPHLPHQRVALSRVPHSFRTAAGRQEP-----------VEGGFDEPVPAGAVAIASITSCTNTANPALMVQAGLLAQRAVDRGLVAKPWVKTSLSPGSRVVEDYLAEAGLLAPLAEAGFGITGFGCMTCIGNSGPLHPAVEQLVR-NGFEPTAVVSGNRNFGGRINPRISLAYLASPPLVVAYALAGTVTHDFETTALGHDHDGNPVHLRDLWPGDDEVRQVVdRAVRRDMFRRNAETLREGTSHWRALPFSEGVRFDWDPASTYIRRPPYLTGLPAEAGSELGLTHGRVLLHLGDDVTTDHISPAGAIPRAGAAGRYLLERGVRPQDLNQYSTRRSNHEVMLRGAFTNPTVTNLLLPPddtRRGAWARTLDGDRVLPVFEAARTYQQAGVPLVVVAGRNYGAGSSRNWAAKAQALLGVRAVIAESFERIHRGNLIGMGVLPLQFPPGRGARDCELTGEDELALTGLDRLEPGiNAVRLTIRRRDGTEDGFDLHLRLDTRHEIDYLRHGGTLPYVVRRMAR
>UniRef50_B9LQV2(20-648:661) Aconitate hydratase n=50 Tax=cellular organisms RepID=B9LQV2_HALLT   E=1e-152 s/c=0.86 id=30% cov=70%
-------------------------------------------------------------------------TPGEEIGIEIDQVLTQDTTGTMVWLQFEAL---------DLDEVQTELAAQY-CDHqTYQFDF----------------KNTDDHRFLRSAAGTY-GAYFSRPGNGICHQVHKE--------------NFAAPGkTLLGSDSHTPTPGGLGELAIGAGGLDIAVAMGGGPYYVEMPEVVNVHLEGELPEWATAKDVALHLLGELTVKGGVGKIFEYTGPGAEKLSIPERTTITNLGTELGATSSIFATDEKTKDWLARQDREEEHVDL------------QPDDDAEYAETIEVDLGELEPLVAAPSMPDNVAPVSEYEGT---------------------------------DVEQVIIGSCTNGAYEDILPSAKML------EGREVNKGTEMIVAPGSKQASEMLAREGWTAEMMAAGVNFSEATCGACIGIG-----------HVPASDSVSLRTFNRNFEGRSGIEDDSVFLCSPEVATAAAITGKI-----VDPRDLAAD-----LGDLEAPGLEMGT---KYGPGMGQDDADIISPDEAIDDGL--VKGPN---------IGDVPLKDGI--------DVDGGEALLKMKDNITTDHIIPATA----------------------DILKFRSNIEKLSEFTLSRVD--------------------------DTFAQRALDADGGVLVAGENYGQGSSREHAALCPMYLGIEAVFAQSFARIHKANLFNFGIVPLAIDAETYEKIEQGDDLEIVDDVPAGVSSGQEEFTVSVNGEWEFTADLDA-----SEREREILSAGGKLSWVKQQ---
>UniRef50_D0L8D8(3-652:674) Aconitate hydratase n=12 Tax=Bacteria RepID=D0L8D8_GORB4   E=1e-144 s/c=0.79 id=28% cov=71%
------------------------------------------------------------------------MSPGSEIALRIDQTLTQDATGTLVMQELE---------GLELDRARTEVSVQYV-DH---------------NLLQTDEKNAEDHDYLRTACARY-GLWYSKPGNGVSHPTHMQRFG-------------IPGKTMVGSDSHTPAAGSLGMLAIGVGGLEVALAIAGHPLNIRMPEIWGVRLEGELPQWCSAKDVILEMLRRHDVKGGVNRIIEYHGPGLAGLTAMDRHVIANMGAELGATTSVFPSDDAVREFLAAEGREDDWIELL------------ADDDASYDVEETIDLSEIEPLIAKPSSPGNVVPVREVAGE---------------------------------PISQVVIGSSANPGLRDFAIAAAMVAD------RQTVPEVSFDINPTSREILTDLTMMGATANLVIGGARIHQAGCMGCIGMG-----------QAPATGSNSLRTMPRNFPGRSGTTEDSVWLCSPETATASALTGVI-----TDPRDWAADVDMAYPELDLPQQHSINTAMLVEPP------------PADEAQKVEPVKGPN---------ISSLPELDD-------LPDEIEAPVLLKLGDNISTDEISPAGARA----------------------LPFRSNIPKLADFSFTRVD----------------------ETYPDRAREAESTGH--VIVGGDNYGQGSSREHAAIAPRHLGLRIVIAKSFARIHWQNLANFGVLAVEFDDES--DYDDIDQDDVLHVENLRDTLESKD-EINVHNVTKD-KTFTVRHRL-SARQIADVLAGGLIPRLA-----
>UniRef50_C0CW95(21-628:655) Putative uncharacterized protein n=2 Tax=Clostridium asparagiforme DSM 15981 RepID=C0CW95_9CLOT  E=1e-139 s/c=0.82 id=31% cov=63%
-----------------------------------------------------------------------RMETGTEIFLKVDSTLVHDMSGTLAYIGFEAM-------GIDKIQV----PAAVTFqDH---------------NLVAMDHRSLDDHRFVASAARRYGSI-LSKAGNGICHSVYYSRIGR--------------PGTVLaGADSHSATAGALGMLGVGLGGLDVSAIMGGEPMELKMPAVIGVEVKGRLKPGVSAKDAALWLLKQLSVKGGVGKVLEYFGEGVENLSVPQRATIANMGAEMGATSSVFPADEAVRRFLKAQGREEDYLELA------------ADPGAVYRLRLTLDLSRIVPSVAVPPMPDQVKSVREAGP---------------------------------VKVDQVYIGSCTNGSYYDLARAARVL------EGRRVHPDVNLLVSPSNRQVYQMLLEDGSIGQFIRAGARIMECGCGPCIGLGQAPPTGG-----------VSVRTSNRNYRGRCGTADASVYLTGPETAAATAVLG--------------------YLAEPGDVMEDLTELERVAEPEKYPVDDSLLFCYGQKTEQTELIKGPN---------IREMP-------VKGPLDANIGARVVLKAGDNITTDDIIPPGP----------------------EVLTLRPNIPALSRYLFQKID----------------------PGFADRAEEYGC----SVIVAGENYGQGSSREHAAIGPMYLGVKAVLAKSISRIHRSNLINYGIVPVLF---------------------------------------------------------------------------
>UniRef50_Q8TQZ3(16-420:420) 3-isopropylmalate dehydratase large subunit 2 n=7 Tax=cellular organisms RepID=LEUC2_METAC  E=1e-109 s/c=0.98 id=29% cov=43%
----------------------------------------------------------------------------------------HDITGPLAVQGFyEIMRDEEEKKVWDPSKI------VIIFDHQVPAD---SINAAENHIMLR--------KFAK--EQGILNYDVY---EGVCHQVLPE-------------KGHVLPgDLIVGSDSHTCAYGSLGAFSTGIGSTDMAAVFATGKLWFRVPETFRFEVEGKLPERVYSKDLILHLIGDVGVEGARYMAAEYAGSTIRSLSIPERMTISNMAIEMGGKAGIIEADEVTEAYLQER----------IPGYKLDPYW-KSDEEAKYLDIRHYDVSDLEPQVACPHNVDNVKSVSEVEGT---------------------------------KLDQVFMGSCTNGRFEDIKIMADIMGDEPVAKG------VRLLVVPASKTEYMKLLKAGYVEKLMNAGAIVEAPCCGPCMGGSFGLLGPGE----------VGLATSNRNFKGREGSAESFVYLSSPATAGASALTGEI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_O27439(3-415:419) 3-isopropylmalate dehydratase large subunit 1 n=12 Tax=Euryarchaeota RepID=LEUC1_METTH  E=1e-108 s/c=0.95 id=26% cov=33%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVGTDSHTCTHGALGAFATGIGSTDMAMVFATGKLWFRVPETLRFDVRGKLREHVYAKDVILNIIGRVGADGATYMACEFAGETVAEMSVSDRMVLSNMAIEMGGKTGIVEPDEKTLNYVRRRSGKPWRV-------------FKTDPDAPSLSVMEVDVSDLEPQVACPHNVDNVKPVTEVEGT---------------------------------EIDQVFLGSCTNGRLSDLRDAAAIL------KNRKVSDSVRMLVIPASREVYRRALDEGLIEIFVDAGALVCNPCCGPCLGGHVGLVGPGE----------VSLSTSNRNFRGRQGSPEAEVYLSSAAVAAASAVKGSI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q6L0K5(14-413:413) 3-isopropylmalate dehydratase large subunit n=2 Tax=Thermoplasmatales RepID=LEUC_PICTO  E=1e-100 s/c=0.92 id=30% cov=35%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVCHQVMME-------------KGFAAPGRLIaGADSHTNTYGALSCVSVGIGSTEAGVIFGTGRMWFKVPETDLIRINGRPKKGVYGKDIILNVLSRIGNGGSAYKCMEFTGSTIDYLDINERMTMANMTTEAGAKCSFFNADEKTLDYIRNK--------------TNDYKIYKDDENAEYSRIIDIDASEIEPSVAIPNSPDNVRPVSKVSE----------------------------------RIDQAYIGSCTNGRIEDIRRAALILKDKKIDK------NVRLMVVPASQEVYNQALKEGLVDIITDAGGYFAGTTCGACLGGYMGVLGPGETCI----------STTNRNFIGRMGDRTSRVYLANPEVVAASAIMGRI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q15S62(25-466:467) 3-isopropylmalate dehydratase, large subunit n=4 Tax=Proteobacteria RepID=Q15S62_PSEA6  E=1e-98 s/c=0.82 id=30% cov=37%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLVCPDSHTCSQGALGALAWGIGSSEAEHALATKTLRVSKPKTMRVNFHGEMGFGVSAKDMILHLIGTYGAAGGAGYVIEFAGSAVEALEIEGRLTLCNMAVEFSAFSGLVAPDEKAITYLK--GREYAPKG--ELWQQAVTYWQSlfSDEQAQFDKTIEIDCADISPTITWGNSPQHACSVnSRVPSAQADATQNQLKALKRAYEYMDV---QPGSALKGLPIGAAFIGSCTNSRISDLRLAAKVL------KGRKVADNVNAICVPGSTTVKRQAEAEGLDKIFIAAGFEWREAGCSMCFFAGG----------ESFGYRQRVVTSTNRNFESRQGPETRS-HLASPATVAASAIAG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8I2I1(35-416:418) Homoaconitate hydratase family protein n=1 Tax=Clostridium cellulolyticum H10 RepID=B8I2I1_CLOCE  E=2e-98 s/c=0.95 id=27% cov=34%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIVVGVDSHTCTYGGLSAFSTGVGSTDMACVWATGKLWFRVPETTKIIFSGELPKGVYAKDLALYLIGQLGINGANYDMLEFDGELIKNLDISSRLTLCNMVIEMGAKAGIINADAVTQKYFR------------EKNLKTEDIDFNSDNGARYKKIIEIDVSKIEPVIACPYSPGNI---------------------------------KTAKELVDLKIDQVVIGSCTNGRIEDFRVAHKYLKDNEVHH------EVKLIVIPGSQEVLKQMEEESILIDFIKCGALISPPTCGPCMGGHMGVLANNE----------IGLFTTNRNFLGRNGDSSAQVYLCNPAIAAYSATKGSIQI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q08N42(142-656:691) Aconitate hydratase n=2 Tax=Cystobacterineae RepID=Q08N42_STIAU   E=5e-94 s/c=0.68 id=27% cov=51%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GADSHTSSHGGLGAFAIGLGGADVTAALVLGQSWLEVPEAIAVEYQGEPPFGIGGKDIILKTLGTLGRNTVaLERSVEYRGPAVRGFSTDMRFTIANMTAEFGGLNGIFEADEAAARWLSRR-----------SSDKDEALYFQADPDAPYVARHPIDLRRMGPLLARPFSPDNVMEVSEAAG---------------------------------MALDGCFIGACT-TSEEELVLAA-LVLEQALQGRAPLPPSPQKLVVPGDLSIAAHLRQAGLWTLYERAGFRIGAPGCSMCLGVASEKARPGEVWL----------SSQNRNYENRMGPG-SLAWLASAATVAASSLPMAV-----TDPRPFlARVDQDRFLRILGRPSRTHALTLRAFEPKVAVDASAKAPAP--------------------------LPFQAGTR---------LRGRV-QRFGDHVDTDAIIP----------GEFCHLMDMEE---------------IGRHAFHHVRPE----------------------FYARAQAGQT-----LVVAGEGWGSGSSREHAVWALQGAGIQAVIARSYGFIHKRNLVNEG---------------------------------------------------------------------------------
>UniRef50_Q1AVC5(17-412:424) 3-isopropylmalate dehydratase large subunit 2 n=4 Tax=Bacteria RepID=LEUC2_RUBXD  E=6e-94 s/c=0.88 id=29% cov=30%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGDSHTCTYGALGAFGTGLGSTDIAACLAFGEFWQQVPGTIQVEFTGHKGSFVAGKDLILAVIADIGVGGGANAVLEFVGEGAASLSLDDRLAVANMAVEAGAETGIFPADEVTARYLDRRADREWHPE-------------RSDPDASYVRKVKIDLNSLEPLVALPHSPGNVVAVSEARGT---------------------------------KIDQVYIGNCSNGTITDLRQTAEIL------RGNRVHPDVRAIIVPASQKVYRQAISEGLIDVFVEAGAVVSTPTCGACFGGHMGVLAEGERAI----------TTTNRNFKGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1Y579(7-421:423) 3-isopropylmalate dehydratase large subunit 1 (Isopropylmalate isomerase 1) (Alpha-ipm isomerase 1) (Ipmi 1) n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y579_9BACT  E=4e-90 s/c=0.81 id=27% cov=33%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSHTTVHGAFGCFATGCGSTDMVAVTRFGKTWIRVPATFRVNVTGKLPKAVYSKDIMLKLASIIKSDQAIYKSLEFRGDTIHSLSQEARLTITSMGVDLGAKNAIMETDDHTREFLRQMGREEDYREIV------------ADDDANYERVIDIDVTKLEPLVSKPHYVENVDLV---------------------------------KNCEDEKVNLIYLGSCTNGRIEDMHIAADIL------RGKKVAKGVRLLVIPNSRYVYHECLRDGTLLTLAEAGAMIEAPNCGPCMGVHQGIPSDGE----------VVVATQNRNFKGRMGNPTARIYLSSPATAAATALTGHI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2A7L6(5-395:398) 3-isopropylmalate dehydratase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A7L6_NATTJ  E=1e-88 s/c=0.84 id=29% cov=31%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVGADSHTCTAGASGALSVAVGSTELAAVMALGTIDLEVPDTYLIQIDGELPQGVYAKDIILTILGKFGTNGFTDKAVIFGGGGITNLSIDEKMTISNMAIEMGAMIGY--VDQ------------GEEIGSVK-------------------ESYTIKASELEPVAACPASPGNVKPISQVAGT---------------------------------EIDQVVIGSCTNGRFSDMEIAAKVL------DGKRISENVDMIVIPASEKVLVEMEKREITETLRNAGAVITNPGCGPCYGAHQGLLAPGE----------VGLSTTNRNFPGRMGHPEAEIYLVSPRTAVESALTGKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0LNR9(29-417:419) 3-isopropylmalate dehydratase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNR9_HALO1  E=3e-87 s/c=0.84 id=29% cov=36%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GICHQLLVE-------------NPLCQPGSLiVGADSHTIMAGALGACATGMGSTDILFALATGTTWMRRPESIRIELRGALPAACSGRDIILELLRLLGEGGAQYRSVEFHDRCTTPLTQDTRFAIANMAVEAGAKFGVFQPDDVTVAYcAKRDGRPPERLVY-------------ADADARYERVIEFDVSQLTPRVARPWSPANVVALSELPDT---------------------------------PITFAFLGSCSSGRIEDLREAADEL------RGRQVHPSVRFVVIPGSRDVLRQALREGLVTELTDAGALFNQPSCGPCGGIDKGVLARSD----------VCVSTSNRNFRGRMGHWDSRTYLASARTVARAALRGKLSGDL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q938C9(2-408:422) 3-isopropylmalate dehydratase large subunit n=7 Tax=Bacteria RepID=LEUC_MYCS2  E=5e-87 s/c=0.80 id=27% cov=40%
-----------------------------------------------------------------------------------------------------------------PLMINDASKVAIVMDHAVPAptikDAAGGPNARKFANDYGIER------FYDVGRH------------GICHQVIAE-------------NGLARPGeILACTDSHTCAGGAFNTAARGLGPAEVYSILCTGQTWFQASPTIRYELIGSMPAGVSGKDVFLYIADAFG--DATNSNLEYGGPGLASIPLNDRRTIATQGAEISADFSTFAYDDVLAEHFDDLG--------ITSYEPAH-----ADPDAAYAAVREIDLSALAPYVARPGTVSrNGVSVDEVEPR---------------------------------KIDQAFIGSCANGQLDDLRIAAEIL------RGRRVAPGVRLIVTPASQQVYRDAMRLGYLQDIADAGAVITNSTCGACFGYHMGVVGPGE----------VCLTSSTRNFTGRMGSTEAEIYMASPATVAASAVAGHI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q8TW29(14-394:402) 3-isopropylmalate dehydratase large subunit 2 n=1 Tax=Methanopyrus kandleri RepID=LEUC2_METKA  E=2e-86 s/c=0.85 id=30% cov=40%
----------------------------------------------------------------------------------PDVIMLHDGSGATA---LRTLRELGVERVESPEKV------VLIFDHSVP--PSSVEAANRQNELLEFARRH-----------RIEHVHV---DEGVCHQVLVE-------------EGYAGPGRVVfGGDSHTPTSGAASALAFGFGGTDMAFALLYGELWIRVPRTVRVHVEGELEEPATAKDLALTVVGELGAGYADYAVLEYTG-LPERMSLGDRMCLCNLATEAGAKSAYVPPKE-----------GPEELRPGDA-----------------DEVIELDASEVEPVVSVPHRVDDVRPVGDV---------------------------------QGVEVTRVFVGSCTNGRYRDVRVFTEILEELD-----GPHPDVRIVVVPASRRVLERMTEAGLTLKLIRMGVMIAPPGCGPCLGEHLGVL----------GDDDVCVSTANRNFPGRMGSRRAEIYLASP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0RZ69(22-571:680) 3-isopropylmalate dehydratase n=1 Tax=Paracoccidioides brasiliensis Pb03 RepID=C0RZ69_PARBP  E=3e-83 s/c=0.57 id=24% cov=48%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLLTKRSKNMRVQVDGELPPGVTSKDIVLHVIGVIGTAGGTGAVVEFCGSAIRGLSMEARMSICNMSIEAGARAGMVAPDEITFEYLK--GKPLAPKYDSPEWKKAVKHWssLKSDEGAIYDKDVFIDTKDIVPTVSWGTSPQDVVPITGV--VPGPDDFTDENQKASPKRALEYMGLTAGTPMQDIIID------------------------------------------------------------------------------------------------------------KGRQGAGGRT-HLMSPVMAAAAAVVGKLADIRKIETLRPLT-------HSVTSAKLDVHAYVDEIDSESDLDRILDFPEDNEPHTNTSSPHTTTG-----------LPKFTTLNGVAAPLDRA-----------NIDTDAIIP---------------------KQFLKTIKRTG----LGSALFYHLRF--------------NEDGSEISDFILNKEPYRNAK---ILVVGNNFGCGSSREHAPWALLDFGIKCIIAPSYADIFFNNTFKNGMLPI-----------------------------------------------------------------------------
>UniRef50_B3MUF5(245-441:445) GF20672 n=1 Tax=Drosophila ananassae RepID=B3MUF5_DROAN   E=8e-74 s/c=1.43 id=58% cov=22%
-----------------------------------DSLPFSIRVLLESAVRNCDNFHVLEKDVQSILGWtpgLKQGANDVEVLFKPARVILQDFTGVPAVVDFAAMRDAVRQLGGNPEKINPICPADLVINHSVQVDFARTSDALSKNQSLEFERNKERFTFLKWGAKAFDNMLIVPPGSGIVHQVNLEYLARVVFEsNEADGSKILYPDSVVGTDSHTTMINGLGVLGWGV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6G875(156-641:643) 3-isopropylmalate dehydratase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G875_9DELT  E=1e-70 s/c=0.56 id=27% cov=33%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIIVLTDSHTPTAGVMNAFAFGVGSTAMAFALRTGMIPVTVPKTVRVWVEGDAKGVLSPKDLVLHLIGdpffreeQWRESPTDTCVIQLGGPGLDQWNVDELSVITNMTVEGGLMTGIVEPCAPLREFLKTT-RGQDYAER----------FVEPDEGAEYVKTIHVNLDEVPLTVATPGDSRNRQSLAEV---------------------------------GDVPIHNVVIASCTGGSLADLRAAAEVL------RGRELADKVRVTVTPSSDDVASAAKKEGLLELFTKLGAVVSAPGCGSCIGNGPGIPYEGETTA----------STTNRNFDRRMG-APGPVYLVSPAVAAASAVTG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9EQ29(119-391:660) 3-isopropylmalate dehydratase large subunit n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9EQ29_SORC5  E=3e-36 s/c=0.57 id=24% cov=23%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VWLRPPRSVQIHLSGRVRPFVCARDVALELLRR-NLDEVVRRiegehhapvILEFAGPSARLLSVGDRAVLCGIAPQVGAAAALFVSDEKTEVFLRDQRRSKAHRALV------------PDPGAPCEEVVSIDLGTVDPLL-----------------------------------MDEEGVVRPVRDLAGKPVAQVVLGGDSGVTLRDMLAAALLL------KSKRVPSRLDLLVAPPSRQVLEVLAQSGALVDLVATGARIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8GVU3(1-893:895) Aconitate hydratase n=25 Tax=cellular organisms RepID=B8GVU3_CAUCN   E=0 s/c=1.22 id=63% cov=100%
MASVDSLKARRELKVGKQSYVYYSLRAAEEaGLADVSSLPVSMKVLLENLLRNEDGVSVNEDDLKAVAAWLNNkGSVEHEISFRPARVLMQDFTGVPAVVDLAAMRDAMVALGADPAKINPLNPVDLVIDHSVMVDNFGNPKAYDDNVKREYERNIERYRFLRWGSSAFNNFRVVPPGTGICHQVNLEYLAQTVWTNTVDGAEVAYPDTVVGTDSHTTMVNGLAVLGWGVGGIEAEAAMLGQPIPMLIPEVIGFKLTGAMPEGATATDLVLTVTQMLRKKGVVGKFVEFYGDALANLTLEDQATIANMAPEYGATCGFFPISAATIAYLKGTGRAAERVALVEAYAKEQGLWWEPGvAEPTFTDTLELDLSTVLPSLAGPKRPQDRVLLSDAAAKFAESLAGEFGKAE--NPELRAPVEGEDFDVGHGDVVIAAITSCTNTSNPSVLIAAGLLAKNAVAKGLKAKPWVKTSLAPGSQVVTDYLAKAGLTKHLDALGFNLVGYGCTTCIGNSGPLPEAISKTINDNDLVACSVLSGNRNFEGRVNPDVRANYLASPPLVVAYALAGSLKIDLATQPIGQDKKGNDVFLKDIWPSNEDIAALQRKaINEKMFATRYGDVFKGDKNWQGIKVTGGQTYAWEADSTYVQNPPYFPNMSMTPAPVTDIVEARILAVFGDSITTDHISPAGSIKASSPAGKFLIDNGVEPVDFNGYGARRGNHQVMMRGTFANIRIRNRITPDIEGGVTKHFPTGEVMSIYDAAMKYQEEGRPAVVFGGKEYGTGSSRDWAAKGTKLLGVRAVICESFERIHRSNLVGMGVLPLQFVQD-GWQKLELTGEEIVSIRGLTDLAPRKQLIVELyRPTDGRIARFPVRCRIDTPTELEYFKNGGVLNYVLRNLAK
>UniRef50_Q94A28(98-992:995) Aconitate hydratase 3, mitochondrial n=390 Tax=root RepID=ACO3M_ARATH  E=0 s/c=1.20 id=55% cov=97%
---------------GGEYGKYYSLPAL--NDPRIDKLPFSVRILLESAIRNCDNYQVTKDDVEKILDWENTSTKQVEIAFKPARVILQDFTGVPVLVDLASMRDAVKNLGSDPSKINPLVPVDLVVDHSIQVDFARSEDAAQKNLELEFKRNKERFTFLKWGSTAFQNMLVVPPGSGIVHQVNLEYLGRVVF----NSKGFLYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEAAMLGQPMSMVLPGVVGFKLDGKLKEGVTATDLVLTVTQILRKHGVVGKFVEFYGEGMSELSLADRATIANMSPEYGATMGFFPVDHVTLEYLKLTGRSDETVSMIESYLRANNMFVDynePQQERAYTSYLQLELGHVEPCISGPKRPHDRVPLKDMKADWHACLDNPVGfkgfavPKEKQEEVVKFSYNGQPAEIKHGSVVIAAITSCTNTSNPSVMIGAALVAKKASDLGLKVKPWVKTSLAPGSRVVEKYLDRSGLRESLTKQGFEIVGYGCTTCIGNSGNLDPEVASAIEGTDIIPAAVLSGNRNFEGRVHPQTRANYLASPPLVVAYALAGTVDIDFEKEPIGTRSDGKSVYLRDVWPSNEEVAQVVqYSVLPSMFKSSYETITEGNPLWNELSAPSSTLYSWDPNSTYIHEPPYFKNMTANPPGPREVKDAYCLLNFGDSVTTDHISPAGNIQKTSPAAKFLMDRGVISEDFNSYGSRRGNDEVMARGTFANIRIVNKLLKGEVGPNTVHIPTGEKLSVFDAASKYKTAEQDTIILAGAEYGSGSSRDWAAKGPLLLGVKAVIAKSFERIHRSNLAGMGIIPLCFKAGEDAETLGLTGHERYTVHLPTkvsDIRPGQDVTVT----TDSGKSFVCTLRFDTEVELAYYDHGGILPYVIRSL--
>UniRef50_Q029J1(12-876:877) Aconitase n=3 Tax=cellular organisms RepID=Q029J1_SOLUE   E=0 s/c=1.19 id=60% cov=97%
------------LRVGNAEYDYFRLASLEEkGVGKISSLPFSIRILLENLLRNEDGKRVLPRDIEAVARG--EGAGIREISFMPARVLLQDFTGVPCVVDLAAMRDALAAMGADPSRANPLMPADLVIDHSVQVDHFGTANSFDLNALLEFQRNRERYMLLRWGQTAFQNFRVVPPDTGIVHQVNLEYLAPVVFR---NPQGVAYPDTVVGTDSHTTMINGLGVLGWGVGGIEAEACMLGQPVSMLLPPVVGFKMSGRLPEGCTATDLVLTVTQMLRKKGVVGKFVEFYGAGLSALSLPDRATVANMAPEYGATMGFFPVDQETLEFLKFTNRDADLIALVEVYAKAQGLFRTDDtPDPTYVDTLELDLATVTPSMAGPKRPQDRVELPDVKKNFRAAFPSAVIPQSRDT-------------LGNGAVVIAAITSCTNTSNPSVMLAAGLVAKKAVERGLKVKPWVKTSLAPGSKVVADYYREAGLMTYLEQLNFHLVGFGCTTCIGNSGPLPEDVTQSVQKENLVVAAVLSGNRNFEGRINPLIKANYLASPPLVVAYALAGSMDIDIANDSLGVGSDGQPVYLRDIWPTTEEVAATVRSaINRGMFEHEYAHAFDGDTNWQGMTIPTGSIYQWDDCSTYIKKPPYFDKMVDPNAPLQDFHQMRVLALLGDSVTTDHISPAGSIPKETPAGQYLIAQGVQPADFNSYGARRGNHEVMVRGTLANIRLRNQLAPKTEGGWTRHLPDGEQMYIYDASMKYQRNGVPLMIIAGKEYGSGSSRDWAAKGVALLGVKAVIAESFERIHRTNLVGMGVLPLQFKAGDSAAGLGLTGEESYHIEGVAGSLNGGgrTATVRAVKADGSEKEFAVDVRVDTPQEVEYYRSGGILPYVLRQL--
>UniRef50_Q6MCW0(9-945:948) Probable aconitate hydratase n=1 Tax=Candidatus Protochlamydia amoebophila UWE25 RepID=Q6MCW0_PARUW  E=0 s/c=1.09 id=54% cov=99%
----------NTLQKLSSNHYYYSLPKLEEHISvSIRRLPISIRIMLESMLRHCDGHLVKEEDVLRVVNWNSRMTPEGEIPFIVSRVILQDFTGVPLLVDLAAMRDAVAKLGLDAKIIEPEVPVDLVVDHSVQVDRAGTNDAFLFNLKIEFERNRERYSFLKWGQKAYKTFQVIPPGIGIVHQVNLEHIAEVVVHKKMEGIHWLYPDTLVGTDSHTTMINGLGVVGWGVGGIEAEAAMLGQPIFIQMPEVIGVHLSGGLKDGVTATDLTLYITELLRNEKVVGKFVEFFGEGAASLTVADRATIGNMAPEYGATMGFFAVDDQTLEYLRMTGRDEQHVQLVKEYLTSQQIFGIPRKgDIDFTKILELDLTQIQPCVSGPKRPQDRIDLSNVKAKFDQLLKIPianggygkaEEKPHIKVHSGGVFFLDHRHEwggtsvfgrmtkeqpwsefemlanrpltppvvnpgyanhideeiiLTHGSIVIAAITSCTNTSNPNVMLAAGLLAKKAVEKGLKVNPMIKTSLAPGSRIVTDYLAKSNLQQYLDQLGFQLVAYGCTTCIGNSGPLDEKIEKAIKHFDLITVSVLSGNRNFEARIHGSVKANFLMSPPLVVAYALAGRIDIDLANEPIGYDQNGQPVYLKDLWPSENEIKKTIRqAIEPDMFKLRYSSISQDNPVWDKIITKEGSQYNWESESTYIRQPPYFENFSLELPNLKKLQDMRPLALFGDSVTTDHISPAGSFKPDSPAGKYLMSLGISEKEFNSYGSRRGNHEVMMRGTFANVRLRNRMVDDREGGLTTLMPDGMELPIFDACQAYADREVPLIIFAGKDYGMGSSRDWAAKGTALLGVRVVVARSFERIHRSNLIGMGILPLEFLPEQSWESLGIIGEELFSIKGFEEaLKPNQELILEIKSED-KIQLVNLRARLETTIEVEYYRHGGILPYVLRYIL-
>UniRef50_A9AVI1(3-885:895) Aconitate hydratase 1 n=3 Tax=Bacteria RepID=A9AVI1_HERA2   E=0 s/c=1.07 id=51% cov=98%
---TVNPAFQRSLECAGQTYRVWSIQALASSYqLELETLPFSLRLLLEAQLRAFGRGLSDLAAIEALINQLQQpdiAQPKVVIPYLPARVLLQDFTGVPVFVDLAAIREAVAEAGGDPSLVNPVVPTDVVVDHSIIVDVAGVPNAFAINTRYEFERNQERYHLLRWSEAAFKHVRVFPPGSGIVHQINLEHLATVVQTQVTATGELMLPDSVCGTDSHTTMINGLGVLGWGVGGIEAEAVMLGYPLMLTLPSVVGVELTGSLRPGVTTTDLVLSLTQRLRQAGVVEQFVEFCGTGVNQLSIAERATIANMAPEYGATCGYFPVDAETIRYLQTTGRSAELIQQVEAYYQFQGLFRQPNAQlPQFAKLIQFDLATVEACVAGPARPQDRLSLRAVPASVVA-------ATQPKQQPITVALDDQTYRLDHGALLLAAITSCTNTSNPAVMLAAGVLAQQAVARGLRVPRYVKTSLSPGSRVVTTYLQEAGLLPALETLGFQIVGYGCMTCSGSSGPIHPQLSQAVAEQGLMASGVLSGNRNFEGRIHPAIRLNYLASPPLVIAYALAGTMNIDLETEPLGYGSDGQAVYLADIWPREQTIqALLANLIKPSMFHKHYQQPVIP-AEWQAITIEKTLFYPWATQSTYLKRPHYIHGKSNQSPSI--IKDARVLALLGDSITTDHISPGGAIDPKGEAGRYLLEQGVAPSDFNAYGARRGNHELMVRGGFANARLKNQLLAGIEGGFSLHQPSGQQDTIYATAMRYATTNTPLIILAGNEYGSGSSRDWAAKAPKLLGVQAVLAASFERIHRANLVCMGILPLEFMAGQPWQSLGLNGAEFYTIYGLDALVAGGECVVEASDADGNVNRWTMRVRIDNPSELRTYYAGGILQQVVQRL--
>UniRef50_Q4SLU0(24-825:1003) Chromosome 13 SCAF14555, whole genome shotgun sequence. (Fragment) n=2 Tax=Tetraodontidae RepID=Q4SLU0_TETNG  E=0 s/c=1.00 id=47% cov=84%
-----------------------------------DKLPLSIRVLLEAAIRNCDGFYTKEEDVENILDW-QQQQNKAEVVFTPARVLLQDFTGIPAMVDLAAMRDAVAKHGVDPSLVNPKCPTDLVCNPEYSKPwWWRRTETALKNQEMELSRNKERLQFFKvnveksplerrdcgltsasggqwnlnlpffhppkqWCSNAFKNVNVVPPDIGAVHQVNLEHLSRVVQV----TDGFMYPDSVVGTDSHTTMVNGLGILGWGVGGIESEAVMLGQPVSLALPQVVGCKLVGSINPLTTSIDVVLGITKHLRQAAIAGRFVEFFGPGVPQLSAPDRTTIANMCPEYNATVSFFPVDQVTLKHFKKTNFNQDKLDLLESYMKAVKLFRsyeDPSEDPEYTEVIEINLSSMVPHVSGPKRPQDRVAVSSMKEDFQSCLDEKVGfkgfhiPKEKQNVRIPLLHCGQEYQLAHGSVVIAAVISCTNNCNPSAMLTAGLLAKKAVEAGLVVRPYIQTSLAPGVGMVTHYLNTSGVLPYFSQLGFEVIGYGCATCVGNTSPLPKPVVDAIKQGDLVACGILSGNRHFEGRLCDCVRANYLASPPLVVAYALAGTMAIDFEEEPLGVSAEGKEVYLRDIWPSREEVQQTEEDTIISSIFKDLRRRIEARESfwnmfWSNIECPDSVVFPWDHKSTYIRPPSFFSKLSKEVPAPQSIENAHVLLFLGNNVTTDHISPAGSIARVSAAAKYLLSKRLTPREFNSYGARRGNDAVMTRGTFASIKLQNRFI-GKAGPKTLHIPSGQTVDVFEAAERYQKEGIPLIIMAGKDYGSGNSRDWVAKGPYLL-------------------------------------------------------------------------------------------------------
>UniRef50_Q0DCP8(33-762:766) Os06g0303400 protein n=3 Tax=Oryza sativa Japonica Group RepID=Q0DCP8_ORYSJ  E=0 s/c=1.07 id=53% cov=78%
----------------------------------------------------------------------------------------QDNTGVPAIVDLAAMRDVMAKLGCDPYQINPLIPVDVVIDHAVRVDVVRSHDALDKNMELEFDRNKERFGFLKWASTAFHKMQVFPPGSGIVHQVNLEYLARVVF----NADGIMYPDSVVGTDSHTTMINSLGVAGWGVGGIEAIVAMLGQPMDMVLPGVVGFKLSGMLRDGVTATDLVLTITQMLRKHGVVGKFVEFYGVGVGELSLPARATIANMSPEYGASMGFFPVDHVTLDYLKLTGRSNETVSMIEAYLRANNMFvehHEPHTERVYSSYLELNLIDVEPCISGPKRPHDRVPLKEMKSDWHACLDSRVGfkgfavPRECQDKVVKFDFQGQPAEIKHGSVVLAAICSSTNTSNPSVIVGAGLVAKKACELGleglpfrfrsknrsspvyrKQVKPWVKTSFTHGSAVTREYLKHSHLQDYLNQQGFHLAAFGCATCVGNSGDLDESVSAAITENDIVSVAVLSANRNFEGRVHPLTRANYLASPPLVVAYALAGTVDIDFEKEPIGHGKDGNEVYLRDIWPTNEEIEQVVKsSVLPHMFTQTYESIKRCNRRWNELRVPGeaAALYPWDPSSTYIRKPPYLEGMAMSPPSRPrSVRDAYCLLNLGDSVTTDHISYSGSITPGSAAAEYLRAAGVADRErLGSYGGRRGNDEVVVRGAFANARIVNKLMNGKVGPKTVHVPTGEELCVFDAAIKYKSEGHNmVIVIAGAEYGSGSSRDSAAKGPMLL-------------------------------------------------------------------------------------------------------
>UniRef50_C9YG83(2-779:781) Aconitate hydratase n=1 Tax=Curvibacter putative symbiont of Hydra magnipapillata RepID=C9YG83_9BURK  E=0 s/c=0.99 id=56% cov=80%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPGFGIVHQVNLEFLARGVHKAKQPraadgskQAAIYYPDTLVGTDSHTTMINGIGVVGWGVGGIEAEAAMLGQPVYFLTPDVVGFELTGALCEGVTATDLVLRVTEMLRREKVVGSFVEFFGEGTENLALPDRATIANMAPEYGATMGFFPVDERTLDYFKGTGRTKAEIAAFEAYFRAQGLFGVPGgksasaemKDIAYTRVVKLDLRDVTPSLAGPKRPQDRIELGHVADKFTELFSLPGTANGFNKDAATLHTLYPaplavaaekpakkgkaeptPLLVQNGDVLIAAITSCTNTSNPSVLLAAGLLAKKAVKAGLTVAPHIKTSLAPGSRIVTEYLTDTGLLPYLEKLGFSLAGYGCTTCIGNAGDLAPELNAVITENDLVCAAVLSGNRNFEARIHPNLKANFLASPPLVVAYAIAGNVTRDLMTQPVGQGKGGKDVYLGDIWPSSDEIYKLLKfAMNGKAFRANYAKVkSEPGKLWEEIKGVSGQTYTW-PASTYIAKPPFFDTFAMEKGaasadstgakgskgskvSAETVQGARIMALFGDSITTDHISPAGNIKESSPAGQWLVANGVQKADFNSYGARRGNHEVMVRGTFANVRIKNLMVPPKedgsreEGGVTVYQgaeGSVEKLSIFDAATRYQAAGIPTVVFAGEEYGTGSSRDWAAKGTHLLGIKAVVAQSFERIHRSNLVGMGVLPLQFKAGESWKSLGLTGNETISIVPDADLAPQSEAQLLVTRADGTQTRHTLLLRIDTPVEVDYYRAGGILPFVLRQLL-
>UniRef50_Q39RZ3(18-643:648) Aconitase n=49 Tax=cellular organisms RepID=Q39RZ3_GEOMG   E=1e-157 s/c=0.89 id=31% cov=70%
--------------------------------------------------------------------------PGTEIALKIDHALLQDATGTMAMLEFIAM-------GVDRVKVELAAQY---IDH---------------NLLQTDNRNADDHIFLMTAAQRF-GIHVSKPGNGVSHQVHLERFG-------------VPGKTMLGADSHTTSAAGLSMIAIGAGGLDVSLAMAGHPFHLPCPKIWGVKLTGELQPWVSAKDVILEMLRRHTVKGGVGKIIEYYGPGVATLSATDRAIIGNMGAELGATTSVFPSDHRTREFLEAQGRGQLWQELA------------ADPDATYDEYEEIDLATVEPLIARPSSPDNVVRVAD---------------------------------IEGLKVDQVLVGSSANSAFRDLMTVCRILD------GRRIAPHLSFNVNPGSRQVLENVADQGGIMMLLLAGAQIHQPGCLGCIGMG-----------QAPGTNQVSLRTFPRNFPGRSGTKNDLVYLCSPETAAAAGLFGVVT--------------DPRKLEGLMP-------WPNVQNPENYILDDSSIifPLPPEEAKRVEIVTGPN---------IIPFPDYD-------PLPETLEAEVILTVGDNISTDTIMPAG----------------------NKVLPYRSNIPAISQFVFEHLD-------------------------PDFHKRAKEKGNG-VVIGGENYGQGSSREHAALAPRYLGIRAKIVKSFARIHKANLVNFGILPLTFRNPADYDLVK--QGDRLVFPDVRRLVASGAAEIPV-RVDGREIVTILEV---SDRQRQELLAGGTLNFV------
>UniRef50_B2IHN6(19-641:668) Aconitate hydratase n=21 Tax=Bacteria RepID=B2IHN6_BEII9   E=1e-149 s/c=0.85 id=31% cov=70%
------------------------------------------------------------------------MNPGAPITLRIDQTLTQDATGTLVMLTLEAM---------ELDHVKTEVSVQYV-DH---------------NLLQIDNLNADDHLFLESACRRF-GIWYSRPGNGISHVVHMERFGRPGK-------------SLLGSDSHTPAAGSLSMLAIGAGGLDVALAMAGEPYPTAMPRIFGVELKGALPDWVSAKDVILEMLRRHGVSGGVGKIIEYYGPGLDCLSAMDRHVIANMGAELGATTTVFPSDEETKKFLEARGRGRDWCAIA------------ADPGCEYDDHDEIDLSKLEPLIAQPSSPGNVVAVKD---------------------------------IEGEDIYQAYIGSSANPGWRDFAVAAEIV------RGKSIPAHVSFDVNPTSRQGLEILVADGHLNDLLVAGARIHQTGCNGCIGMG-----------QAPAIGKNSLRTTPRNFPGRSGTEEDAVFLCSPETAAASALTGKI-----TDPRSLSMSYPRLR------EAESIAMTSSLIAS----------PLSFEEARRVTLVKGPN---------IRSLPTLD-------PLPDSLDLPILLKMGDNVSTDEIMPAGA----------------------KVLPYRSNIEKIATFSFERI-------DETYVERTRTVPGHA-------------------VIAGRNYGQGSSREHAAVGPRSLGLRLVLAKSFARIHRQNLINYGVLPLVFVEPKDYDSL--EKDDVLAVRDLRRILEKGDEVVALESKGATKGVILARHGL-TPKQIEIILAGGVTN--------
>UniRef50_B8MSQ2(408-1136:1138) Homoaconitase LysF n=6 Tax=Eurotiomycetidae RepID=B8MSQ2_TALSN   E=1e-141 s/c=0.69 id=26% cov=63%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAGRGIGHQIMVE-------------EGFAWPGTlVVASDSHSNMYGGVGCLGTPIVRTDGASIWATGKTWWQVPNIARVHFTGVLPAGVTGKDVIVALCHLFGKDDVLNHAIEFTGseETMRSLRVDDRLTIANMTTEWGALSGLFPIDDVLKGWLRgkattaAMGLADGPYKTLAAqrftHERLEELFANaltADKGAKYAKELFLDLSSLSPYVSGPNSVKVATPISEL-------------------------------EAQNIKVNKAYLVSCTNSRASDIAAAARVFREAAEANGgkiPKVADGVKFYIAAASLPEQQAAEDAGDWQVLLDAGAEALPAGCGPCIGLGTGLLEPGEVGISA----------SNRNFKGRMGSTDAKAYLGSPEVVAASALSGILKGPGWYEqPEGWTgvirGEGDGIKEEDRTLTAEEALEKVIGQLDNLIADGEQRFGLSEQEETTSEEKKDD-----------------SALTELYPGFPERISGEIVFCDADNINTDGIYP----------GKYTYQDNVPVE------------------TMAQVCMSNYDSSFSTI-----------------------AKEGDILVSGFNFGCGSSREQAATAILAKKIPLVVSGSFGNIFSRNSINNALMGLEVP------RLVERLRESFGEGNVPTRRTGWTLTwdvrrsqIEVREHDGTTWTHRV----------------------------
>UniRef50_Q58FL6(66-767:769) Homoaconitase, mitochondrial n=19 Tax=Dikarya RepID=LYS4_ASPNC   E=1e-137 s/c=0.70 id=26% cov=58%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAGRGIGHQIMVE-------------EGFAWPGTlVVASDSHSNTYGAVASVGTPIVRTDAASIWATGKTWWQIPPVAKVTFTGILPPGVTGKDVIVALCGLFDKDDVLNHAIEFTGseETMRSLPMDSRLTIANMTTEWGALSGLFPMDGVLKGWLKgkattaAMGLADGPFKTLAArnftHPAIEQLFVNPltaDKGAKYAKELFLDLSTLSPYVSGPNSVKIATPLKEL-------------------------------EAQDIKVDKAYLVSCTNSRASDIAAAAKVFKDAAEKNGGKVpkiADGVKFYIAAASIPEQLAAEGAGDWQTLLEAGATALPAGCGPCIGLGTGLLEPGEVGISA----------SNRNFKGRMGSTEAKAYLGSPEIVAASALSGKLSGP-------------------GWYQPPEGWTEVVRGEGDGIREEDRMLNTEQALEKLLGQLDDLVADGEKRFAPEEKVEEEGGLTEVYPGFPERVSGEIVFCDADNLNTDAIYP----------GYWTYQDNVPVEKM------------------AEVCMSNYDK-----------------------EFASIAKEGDILVVGYNFGCGSSREQAATALLAKQIPLVVSGSFGNIFSRNSINNALMGLEVP--------------------------------------------------------------------------
>UniRef50_C0WAZ4(103-752:757) Putative uncharacterized protein n=1 Tax=Acidaminococcus sp. D21 RepID=C0WAZ4_9FIRM  E=1e-122 s/c=0.68 id=24% cov=67%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSHTR-YGSLGSLSIGEGGPELAKAMLGKSYALKYPKVVAVFMTGMPKPWVGPMDVILSIIGEVFKNGFVkNCVLEFVGPGVENLSMDFRNGIDTMTTESTCLSSLWTTDAKTEEYFAIHGRPEDYKEM------------KPDDAALYDKVIEVNLDTIEPVIALPFHPSNVYSLKEIiadPKAALSIIDKNAKRTFENNPNVHWNLAGKIHDDGKLYVDQGVIAGCCSGSFENLYAVGKM--AEYMNHGVG---SFNFNVYPASQPIMTALMEAGTIKTLMDYGVRVKSAFCGPCFG-AGDTPANNEFSIRH----------TTRNFPNREGSNPAMNQFSCVALMDSRSIAAT-----------SFNGGKLTSAEDVW---QDITYPKYHFNSQIYENTvYNGFKKAEKDVEMVYGPD------------IRDWPDMTE-------LADDLLLKVASVIHDEVtTTDELIPSGETASYRSNPEKISAFTLIRKDPKYVGRAKTVRE------FERARLKGDEKTAME-----YFSILEKAGIFVPKDRLMNHtGIGSVLYA-KRPGDGSAREYAASCQKVLGGFANICIEYAtKRYRSNCVNWGILP--FTYGTDP--IDLQPGEYIYLSNIRNSVEKGltEVEATVISEDGKTRVMKLNLPDVTEAEKQVLLAGSLINF-------
>UniRef50_A2R6F2(114-647:691) Catalytic activity: 3-isopropylmalate dehydratase n=9 Tax=Leotiomyceta RepID=A2R6F2_ASPNC  E=1e-119 s/c=0.81 id=26% cov=58%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVGSDSHTCSSGALGCLAIGLGAADVTLPLVTGETWFKVPESVNIRLVGAPKPGIGGKDTILYILQQLKRNTVaADRIVEFTGPGVKHLSCDARFAISNMTTEFGGITGVFVPDQITEEFIQKRRLPRH---------KTASVYFKPDDDAEYAETHEIDLGEVRSFLAKYPNPDDVVPVTE---------------------------------QEGMHLDGCFIGACT-TAEEDLILGA-LVLEQGLQNGLKPVSHGKRKVVPGSVPILHRLRELGLAQIYEDAGFEIGIPGCSYCVGMSADQAGPGEVWI----------SSQNRNFENRMGKGSIGNLASAATvaassfemkLKDPHEYLAAIDLER-----WHTLRGVSVSATD--STQEHISYMEPSGSATAEAKTVDSP--------DVKVTEANTPETADSSSS------------------DLMTGKV-QRLGDFIDTDALAPAQFLIGMS---------------------------------------NNQIAGEHCLEHTHPEFRQRVKDGFN------------IVVAGKAFGCGSSREQAVMALLGCGVQCVIAKSYSFIFQRNMPSLGLLGITLTDEEFYDAAQ-DGNE-ISI----------DFKTKVINVDGKQYAFQL-----SQMERELFQHGGI----------
>UniRef50_C4Z1K2(124-581:586) 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z1K2_EUBE2  E=1e-115 s/c=0.91 id=27% cov=51%
------------ITVNGKTYTCTKLPAKMQAILNQGGLIASLdgeKEESESTAVPADeakHGMTIAEKIIARAAGLSQVKAGDIATVTLDRLMSNDGTTHLTI----GMYEKLKNP-----HIADKDKLVWIVDHNIPSDS--PKTAASQKKMRDFAKANDI-KFYE--------------GEGVCHQVMME--------------NHVVPGELIfGADSHTCAYGALGAFGTGVGCTDYLYAMVTGTSWVMVPGTLRFNLKGKLNDGVYARDLILSIIGKIGANGANYKAMEFAGEGLHSLSMADRISICNLCVEAGAKTALMEVDDVAMDYLKEHGREPKAC-------------FTSDDDAVFEQVYDIDLSTIQPIVAKPHFVDNVVPAKESLG---------------------------------VKIDEAFLGSCNNGRIEDLRVGAAII------KGKKVAPKVRFLVVPASRSVYLQAMKEGLLDIFMDAGAIVMNPNCSVCWGSCQGVIGEGETLI----------STGTRNFKGRAGHKDSFVYLASAATVTASAIKGEI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1B6F6(8-419:420) 3-isopropylmalate dehydratase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F6_THEAS  E=1e-112 s/c=1.00 id=28% cov=33%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIGSDSHTCTYGAFGAFSTGIGRSEMAAAWATGKIWFRVPESMKITVTGSFPKGVSAKDLILKIIGDIGADGADYMSVEFHGEGILQMSLSERMTLCNMGIEMGAKNAVCPPDQKVLDHVRDIAKSDQW----------EAIW--ADQGATYAKELSYCLSELVPGVAKPHTVDNYAPVDQVKGA---------------------------------QIHQAFIGSCTNGRIEDLREAATIL------KGRQVA--VRTIVIPASWRVYRQAMEEGLLETFLDAGCVISNPGCGPCMGNHQGILAPGE----------TCISTANRNFKGRMGNKDSFIYLASPLTVAASAVAGEI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B5IER5(2-417:418) Homoaconitate hydratase family protein n=2 Tax=Aciduliprofundum boonei T469 RepID=B5IER5_9EURY  E=1e-112 s/c=0.98 id=29% cov=35%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGICHQVMAE-------------KGYDLPGAViVGADSHTTTPGAFGAFAAGIGRSEVAAIWATGKIWLRVPESYEIIVNGKLPKGVFAKDLALHIVGDVTASGAVYKAVEFKGETIKDMTIASRMVLTNMSAEMGAKNGIIEADEKTEAYLKTRARAPYEI-------------MHPDEDAEYERRYEYDASDLVPKIAFPHTVDNVYDID---------------------------------KAEGIEVNQVFLGTCTNGRVEDLEIAARIL------KGKKVNKNVRMLVFPASWDVWREADEKGILRTLAEAGAVIMNPGCGPCLGAHAGVLADGEK----------CLSTANRNFKGRMGNPNAEIYLGSPATAAATALKG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A1HRB9(2-419:420) Homoaconitate hydratase family protein n=4 Tax=Clostridiales RepID=A1HRB9_9FIRM  E=1e-109 s/c=0.95 id=31% cov=35%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGPCHQVMVEY-------------GHVLPGTVVlGTDSHTCMGGALGAFASGVGSTEMLGILLTGKTWLRVPETIKVEWTGRLPDGVMAKDMSLKTIGTIGHAGATYKAVEYVGDAITNLCLDERMAITNMAVEMGAKAGLMAPDTKVVEYLKARGITEGYT------------LFASDSDAVFCATYRFDASELEPVVACPHEVDNVTELSNVKGQV---------------------------------IHQAYIGSCTGGRYNDLAAAARVL------KGRKVANGVRLLVSPASHEIWRQAAADGILSILAEAGAIILAPTCGVCVGLHSGLLADGEYCI----------SSTNRNFIGRMGSKNAGIYLASPMAVAASAITG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8HAC9(30-477:484) 3-isopropylmalate dehydratase large subunit n=491 Tax=cellular organisms RepID=LEUC_ARTCA  E=1e-102 s/c=0.84 id=28% cov=35%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVVCGDSHTSTHGAFGALAMGIGTSEVEHVMATQTLSLKPFKTMAINVEGTLRPGVTAKDIILAVIAKIGTGGGQGYVLEYRGSAIRALSMDARMTICNMSIEAGARAGMVAPDETTYAYMQ--GRPHAPEGADWDAAVEYWNTLKTDDDATFDVEVDLDADTLEPFVTWGTNPGQGVSLSQ--AVPSPEDFGDENAKAAAERALQYMGLEAGTPMKDIRVDTVFLGSCTNSRIEDLRAAADII------RGREKDPKVRMLVVPGSARVRLEAEAEGLDRVFKDFGAEWRFAGCSMCLGMNPDQLEPGER----------CASTSNRNFEGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A5WGT5(32-471:478) 3-isopropylmalate dehydratase large subunit n=270 Tax=cellular organisms RepID=LEUC_PSYWF  E=1e-101 s/c=0.84 id=27% cov=38%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVVCGDSHTATHGALGCLAHGIGTSEVEHVLATQCLVQKKSKNMLIRVNGELGAGVTAKDVVLAIIAKIGTAGGTGYAIEFAGEVFENMSMEGRMTVCNMAIEAGARVGMVGVDETTIEYVK--GRPFAPTGEQWDQAVEYWNTLHSDEGAHFDAIVELDASDIAPQVSWGTSPEMVVDVTQYVPTLAQAKDEVQ--AEAWERAYQYMGLEQGQPITDIKLDRIFIGSCTNSRIEDLRSAASVI------KGRKVAANVKeAIVVAGSGQVKQQAEQEGLDKLFIEAGFEWREPGCSMCLAMNADKLEPQEH----------CASTSNRNFEGRQGNGGRT-HLVSPAMAAAAALAGH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B0TW83(25-459:469) 3-isopropylmalate dehydratase n=12 Tax=Francisella RepID=B0TW83_FRAP2  E=3e-96 s/c=0.82 id=23% cov=38%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLVCGDSHTSTHGAFGALAFGVGTSEVGHVLATNCILQYRPKTMKVEFVGKPSKSATAKDIIMKLIANIGIGGAGGYVIEYVGQAIKDMTMEERMTLCNMSIECGARAGLVSPDEKTFNYLK--GKKYAPQGNDFDKSVEYWNSFISDENAYYDKTIKVDIEGLEPMVTWGINPQHAISIS---AKIPSLKNIPTHQHKLAQQAYDYTKFNADEDILGKEIQWAFVGSCTNGRIEDMRAVADVL------KGRKIAKNVTMYIVPGSEQVRNIAIAEGLDKIFADAGAEFRMPGCSMCLAMNDDKVPEGQRCI----------STSNRNFIGRQG-KGSITHLASPQTVAASAVMGKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A7NPS0(2-406:410) 3-isopropylmalate dehydratase n=1 Tax=Roseiflexus castenholzii DSM 13941 RepID=A7NPS0_ROSCS  E=1e-95 s/c=0.87 id=34% cov=34%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEGICHQLMVEY-------------DHVRPGQIIlGADSHTPTYGALGAFAMGVGSTDLAAAWLTGKTWLKTPASIKIVLDGTLRTGVSAKDLVLFLVRQIGADGARYQAVEFTGSAIRSLSLASRMTLANMTAEMGALTAFV-----------------DLQGLDLPYRFDP---IHPDPDAVYSVVYSFNVDHLLPQVAIPHAPSNVVPIDEVAGT---------------------------------PIQMAFIGSCTNSRLEDLRAAAAVL------QGRKLAPGVRLIIAPASRQVFMMALQDGTIATLTESGATFITAGCGPCVGTHQGIPGNGENVI----------TSTNRNFRGRMGNPHASIYLASPAVVAASALRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1ICY1(66-526:528) Whole genome shotgun sequence of line PN40024, scaffold_56.assembly12x (Fragment) n=1 Tax=Vitis vinifera RepID=D1ICY1_VITVI  E=4e-92 s/c=0.74 id=27% cov=34%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLGTDSHTCTAGAFGQFATGIGNTDAGFVLGTGKILLKVPPTLRFVMDGEMPDYLLAKDLILQIIGEISVSGATYKSMEFVGSTVESLTMEERMTLCNMVVEAGGKNGVVPADSTTHKYL-------------EDKTDVPYEPVYSDEQARFLSEYRFDVSKLEPLVAKPHSPDNR---------------------------------ALARECKDVKIDRVYIGSCTGGKTEDFLAAAKVFH----ASGKKVK--VPTFLVPATQKVWMDvyslpvpgCGGKTCSQIFEEAGCDTPAsPSCGACLGGPRDtyarMNEPQANVIVKlvclavwlfGIHGEVCVSTTNRNFPGRMGHKEGQIYLASPYTAAASALTG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6C2Z1(302-634:646) Aconitate hydratase domain protein n=2 Tax=Proteobacteria RepID=C6C2Z1_DICDC  E=6e-88 s/c=0.98 id=29% cov=34%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGTDSHTPHCGALGCLAIGVGSTDMAASMVTGVFRLMSPDSVRVVFTGRLPEGTGAKDMILQLLSTewIRQGNGIGKVFEFCGDTIERLSIDDRITLTNMVAELGGVSGLIAPDSNTVNFLKERRGIHFTLEP----------WMHSDEGASYAAVIEIDCRELSPMVASPGDPGNGLALSQLTEPV--------------------------------KIDIAYGGSCTAGKRDDFDEYHKVLHW-AVQKGKKIPSDVMLYLQFGTMDVYEYCHERGYLETFKNAGAILLKPACGACANCGPG---------ASFNSNQVTISAINRNFPGRSGP--GKVWLASPSTVVASAVKGEI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6NVP4(5-396:396) Putative uncharacterized protein n=2 Tax=Bacteria RepID=A6NVP4_9BACE  E=3e-79 s/c=0.76 id=31% cov=31%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSHTGTCGGYGVMGVGVGSTELAAAMATGKLDLEVPQVVQIHLTGKKPANVFGKDLILYLGSVFGTDYLVDKALLFTGEGIEDFSVAERMTVCNMGIEIGSMITIF---------------------------------GTTALEPDTAEVREVNLSELEPQIARPFSPANVVPVREVAGT---------------------------------PVTQVVVGSCTNGRINDMEQVAKAF------KGKKVHPDVNTLIVPASRDVLDEMEKRGWCKIIRDAGATVLNPGCGPCFGAHEGLTSERD----------VVVSTTNRNFPGRMGSMKANIYLASPATAAATALAGKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q7WPW8(29-429:436) Aconitase family protein n=2 Tax=Bordetella RepID=Q7WPW8_BORBR   E=4e-76 s/c=0.72 id=29% cov=35%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGISHQVPAEH-------------GWVLPGTVyIGADTQAATLGAFNCFAIPALA-ETPFIMATGDTWFKVPPCVRIRLSGRLPKGVLGKDIYLRLLQDLR-GKLEGCAIEFDGPGVATMPLDVRMAVANGAPHIGATTMIFPSDDILLDYLRPRAREAFAPVA-------------ADGDAAYDQAYEYDLASFEPLIAGPDDPGRISPLRAMAAT---------------------------------RIHAAYIGSCSSGRLEDLTQAAEVL------RGRKISPDVRMVVTPISTEVMLQAVEAGLVAAFVEAGATVTAPGCGACFyGNASPLhLEDGENCITGSVE----------NWPGRMGSNKASIYLANAAVVAASALAGHI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2GXH4(135-524:605) Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2GXH4_CHAGB  E=9e-68 s/c=0.67 id=28% cov=41%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHAWPGTMaVASDSHGTHYGGVGCLGTPVVRTDACSICATDRTWCNVPPIARVRLTGTLPQGVTGKDVIV------------------------------------------ALCGIFKSD-----------------------------VLKPHPDAVYAKQLYLNLSTLSPYVSGPDTVKVATPLHELAP-------------------------------QKIKVDRAYIVSCTNSRASDIRAAAKVFRDAADANGGVVPK------IAGS--------------ILVEAGAQPLMAGCGPCIGLGTGLLEPGEVDISA----------SNRNFKGRMGSRDAKAYLSSPEAVAASALSGIITGP--------------------------------------------GIYQVPKDWTGVDAGYGtglpPTTETELSGLVQQLDSFIDRVESAVTSAEDNNAA-----------------ATEILPGFPS-----------------------------------RISGESSSATPTTSTRTPSTRASSPTKTTIAKPHD-----IIVSGFNFGCGSSREQSATAILARDIPLVVAASF---------------------------------------------------------------------------------------------
>UniRef50_Q9I3F5(1-910:910) Aconitate hydratase 1 n=238 Tax=cellular organisms RepID=ACON1_PSEAE  E=0 s/c=1.21 id=70% cov=99%
--------TLRSLAVDGKTYHYYSLPEAARTLGDLGKLPMSLKVLLENLLRWEDGSTVTGDDLKALAGWLRERRSDREIQYRPARVLMQDFTGVPAVVDLAAMRAAMAKAGGDPQKINPLSPVDLVIDHSVMVDKFASESAFEQNVEIEMQRNGERYAFLRWGQNAFDNFSVVPPGTGICHQVNLEYLGRTVWTKDEDGRTYAFPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPVSMLIPEVIGFKLTGKLREGITATDLVLTVTQMLRKKGVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGFFPVDEITLGYLRLSGRPESTVKLVEAYSKEQGLWREKGHEPVFTDTLHLDMGEVEASLAGPKRPQDRVALQNVASAFNEFLGLQlhpssteegrllseggggtAVGANAAFGEIDYQHDGQTHRLKNGAVVIAAITSCTNTSNPSVMMAAGLLAKKAVEKGLQRKPWVKSSLAPGSKVVTDYFKAAGLTRYLDELGFDLVGYGCTTCIGNSGPLLEPIEKAIQQADLTVASVLSGNRNFEGRVHPLVKTNWLASPPLVVAYALAGSVRINLSEEPLGTGKDGQPVYLKDIWPSQKEIAEAIQKVDTEMFHKEYAEVFAGDEKWQAIQVPQSDTYEWQADSTYIQHPPFFEHIAEAPPAIADVEQARVLAVLGDSVTTDHISPAGNIKADSPAGRYLREHGVEPKDFNSYGSRRGNHEVMMRGTFANIRIKNEMLGGEEGGNTLYVPSGEKLAIYDAAMRYQEDGTPLVIVAGKEYGTGSSRDWAAKGTNLLGVKAVIAESFERIHRSNLVGMGVLPLQFENGQDRKSLKLTGKEVLNIRGLgGELKPHMPLSVEVTREDGSQDSFKVLCRIDTLNEVEYFKAGGILHYVLRSML-
>UniRef50_Q68VV0(1-876:878) Aconitate hydratase n=21 Tax=Bacteria RepID=ACON_RICTY   E=0 s/c=1.21 id=58% cov=97%
---------IKELLVDNTSYKIYDINKAASDIGiSLNKLPYSLRVLLENVLRTSGN----KENLLVFKEWLKTKKSNTEIDFMPARVLMQDFTGVPAIVDLAAMRDAMQKIGCNPLKINPLIPVDLVIDHSVSVDSYGLKESFEQNVQMEMKRNIERYQFLKWGQQAFNNFKVVPPGTGICHQVNLEYLSKVVWYN----DGTAYPDSLVGTDSHTTMVNGLSVLGWGVGGIEAEAAMLGQPLTMIIPEVIGVKLTGKLEGMATATDLVLTITEMLRRTKVVGKFVEFFGYGLSNLTISDRATISNMSPEYGATCGFFPIDQETIKYLEITGRETRQIKLVEKYATEQNLWYNFEDTQEYTEVLELDLSTVYSSLAGPKRPQDRVNLSFVESNFK--NELPYFALENQDIDKKYAVANQNYEIGNGDVVIAAITSCTNTSNPSVMIGAALLAKKALEHGLNVKPWVKTSLAPGSKVVTEYLKISGLDKYLDALGFNLVGYGCTTCIGNSGSLNPEIENTINKNRLVVASVLSGNRNFEGRINPLTKASYLASPILVVAYALSGTLNIDLTTTPI-----GANIYLKDIWPSQKEIDAViANSINPSMFIEKYADVFNGTKEWHDLHITTGTNYNWDKNSTYINNPPYFDNICSE-NTIKDIKSAKILAIFGDSITTDHISPAGSISKNSPAAKYLIEHNIEPLNFNSYGSRRGNHEVMMRGTFANIRIKNEMCNGVEGGFTINQLSGVQQTIYDAAMDYQAHDIPLVVFAGKEYGSGSSRDWAAKGPGLLGIKAIIAESFERIHRSNLVGMGILPLTFTGNNTRLSLKLDGSETIDIIGLsKNIRPFNLVKCVIKKQTNEISTIDLILQIFTENEINYIKHGSIMQFVVESL--
>UniRef50_Q2GIY7(8-869:873) Aconitate hydratase 1 n=5 Tax=cellular organisms RepID=Q2GIY7_ANAPZ   E=0 s/c=1.19 id=55% cov=96%
-------QVRKKLCVAGVSYDYYALDLACQKLGlDIASVPFVYRILLENLLRNEDGLHVKLPDIERFAACVSGGDS-CEVNFMPARVMMQDFTGVPALVDLASMRDFVKAQGKDPSIINPRIPVDLVVDHSLQVDFSGTEGALAENVALEMSRNLERYQFLKWSQQAFRNLRVVPPGTGICHQVNLEYLAKVVW----NHQGVLYPDTLIGTDSHTTMINGISVLGWGVGGIEAEAAMLGQPIVMSVPEVVGFEILGALKEGVTATDMVLTITEILRSRKVVGKFVEFYGEGLKNLSAYDRATVANMAPEYGATCGFFPFDQSTLDYLYVTGRDREYLGVVEQYMRTQGLWCD-NCEVSYSEKLTLNLEDILPVVAGPKRPQDKLFLAQIPNSL----------------PVSTFGEDSHLPVKNGDVVVAAITSCTNTSNPYVMVAAGIVARKARKLGLKTKPWVKTSLTPGSQVVAEYLKISGLQDDLNLLGFNIVGYGCATCIGNSGPLSKEIEECVQSNNLLVASVLSGNRNFEGRIHPSVKANFLASPPLVVIFSLSGTVLIDVTKDPICEDAQGKPVYMQDLWPTTEEIAEIVNKfISRDMFVRKYSDVFLGDAIWQRVESKGDVTYSWSAESTYVQLPPYFTEAETKQKNIEGNalkcNSARVLMLLGDSITTDHISPAGNIAAESPAGKFLLQSGVKEGDFNSYGSRRGNHNVMIRGTFANIRIKNEMLSGVEGGFTRHYPSQEVLPIFDAAMRYSEENTPLVIIAGKEYGTGSSRDWAAKGTLLLGLVAVIAESFERIHRSNLVGMGVLPLIFKDES---RSMFSGNETLTLYG--EIGARKEIKCEVRKSDGTVKTIALVCAVNTAIEVDYLSCGGVLHYVLNRMV-
>UniRef50_B6ADB7(16-942:948) Aconitate hydratase, putative n=1 Tax=Cryptosporidium muris RN66 RepID=B6ADB7_9CRYT  E=0 s/c=1.09 id=49% cov=98%
---------------------YFSLKKL--NDPRLYKLPYCIRVLLENLIRNCDNYLIKKVDIENILDWRNTSKKGnVDISYFPSRVLLQDFTGVPAIVDLAAMRDAIlSKYGLSPEIINPKVPVDLVIDHSVQVDFYGRSDAVKKNLEMEFYRNKERFEFLKWGSKSFDNLRIVPPGFGIIHQVNLEYLARTVFKIPLEKEeidkitldgvnisesdsNILYPDSLVGTDSHTTMICGLGILGWGVGGLEAEAVMLGQPITMNIPEVIGAKLIGNLQPAVTSTDIVLTITSILRQSNVVGKFVEFFGDGIKQLSVEDRATISNMSPEYGATIGYFYPDEYSLHYLSSTGRSSETVHFVQKYLEEQCLGKftsssiSEYSQVEYSEVIVIDLSMIEPCAAGPKRPQDKVALKDLKQSFQTALYAPLSKcgfavKKTDEGCKVVSNYNSNLDLAHGSIVLASITSCTNTSNPLVMIGAGLLAKKAVKKNLKVPEYIKTSFSPGSHIVEKYLQISGLLPYMEKLGFYTVGYGCMTCIGNSGNLSEEISNVIKNKNLVAVSVLSGNRNFEGRVHPLTKANYLVSPPLVIAFALAGRINIDMTSEPLGINHiSGEEVYLKDIWPTREEILELESKiITPKLFNDVYSTIPKGTEQWNSLEVKRTPVFRWNPDSTYIHKPPFFDDKLLKVPTNTKLEDIYCLLNLGDSITTDHISPASDISQISPAAKYLLGRNVKAIDFNTYGARRGNDEVMVRGTFGNVRIINkilykencsdntELHQNIEGPYTLYIPNNEILPIYDAAQKYRENNQlPLLVIAGKEYGSGSSRDWAAKGPRLLGVQVIIAASFERIHRSNLIGMGIIPLQFLEGENADTLGLDGTELFSIDLSEEFKPRDKIEIKVRKRETDKEiVFNTILRLDTNIEIEYYKHGGILPFVLDKIAK
>UniRef50_A1VRP5(15-987:989) Aconitase n=23 Tax=Bacteria RepID=A1VRP5_POLNA   E=0 s/c=1.00 id=55% cov=98%
-------------TASGKTGKLYSLPSLAEQFPMVKRLPVSIRIVLESVLRNCDGKKVTAEHVEQLANWVPQAERSAEIPFVVSRVVLQDFTGVPLLADLAAMRSVAARLGRNPKAIEPLVPVDLVVDHSIMVDYFGTKDSMDLNMKLEFQRNRERYEFMKWGMQAFDTFGVVPPGFGIVHQVNLEFLARGVHRTQDD---VYYPDTLVGTDSHTTMINGIGVVGWGVGGIEAEAAMLGQPVYFLTPDVVGMELTGKLREGVTATDLVLRVTETLRREKVVGKFVEFFGEGTRTLALPDRATIGNMAPEYGATMGFFPVDEKTIDYFRGTGRLDAEIEAFEAYFRAQGLFGVAAAGEiDYSHVVKLDLDDVRPSLAGPKRPQDRIELGDVARQFSSLFSKPNAENGFNQPAgmlgtrhlvrhtddgrpdavpaapptpmgaersvvemesnrptlamaheqggevasasvPAAHAAAQGLTVGNGDVLIAAITSCTNTSNPSVLLAAGLLAKKAVEAGLGVQPHIKTSLAPGSRIVTEYLTQTGLLPYLQQLGFDLVGYGCTTCIGNSGDLTAELNDAINKSDLVCAAVLSGNRNFEARIHPNIKANFLGSPPLVVAYALAGTVMRDLTTEPLGKGKDGQDVFLRDIWPGSDEIHALMKfAMNAEAFRANYAKVkTEPGQLWENIHGVAGNTYNW-PLSTYIAEPPFFNDFAMEMKAPTasgtgengqnnefSVQGARIMALFGDSITTDHISPAGSIKGSSPAGLWLQAHGVQKADFNSYGSRRGNHDVMMRGTFANVRIKNLMIPAgkdgsrEEGGVTLYHPGHrtpesviEKMPIYDAAMKYMAEGTPTVIFAGEEYGTGSSRDWAAKGTQLLGIKAVVARSFERIHRSNLVGMGVLPLQFMPGESWQTLKLIGSEVVDVIPHPELKPQSEARLVITRADGTRQEVTVILRVDTPIEVDYYRNGGILPYVLRQLL-
>UniRef50_C8P7Z1(2-890:892) Aconitate hydratase n=1 Tax=Lactobacillus antri DSM 16041 RepID=C8P7Z1_9LACO  E=0 s/c=1.09 id=50% cov=97%
-------------------HKFYDLKKIAsKYDVDLATLPYTIRVLLENVARNSQPKD-LDQNIIDILNW--NQNSDKTVDFYPSRIILQDLTGVPAIVDLASLRSAAKKMGLDPEKINPEIPVDMVVDHSVQIDHAGNAAAFAYNQKKEFERNHERYEMIKWAQKSFNNLKVVAPDTGIIHQVNLEYLSPVV----QQKDNMLYPDSVLGTDSHTTMINGLGVLGWGVGGIEAEAAMLGTASSFLIPQVVGVHLTGELPSGVVATDLALTITHLLRETNVVGKFVEYFGDGYQNLSVADRATIANMSPEYGATCGFFPFDAQSDEYLRLTGRSEGQIKLISNYLKNNGMYYDPENQTKvnYSTVINVDLSKITTSVAGPKRPQDIIKLDSVPAEFKKSITAPNGnhgfglpAEAIDNHEEVKLSTGEKVNIKAGDILLTAITSCTNTSNPTVLIGAALLAKKAVEKGMKISPRIKHSFAPGSPAVRDYLKSAGLLKYLDDLGFNIVAFGCTTCIGNSGKLDPALEDLLeRRKDLVSVAVESGNRNFESRVHPNIKSNYLASPILVVAYTLAGNIRTNLQTDPIGKDKDGNDVYLKDIWPSTKEIDKYTKKyVSTDIYKKAYNNIFNSNEAWNKLQVNESETFNWNNNSTYIANPPYFDNQIKGDNTLPRLKNMRVLVKVGDSVTTDHISPAGAILSSTPAGQFLESTGVQSVDFNTYGSRRGNHNVMIRGTFANYSLHNQLAAGRQGGFTKVLPDNKLTTIFEASQKYQNDGTELLVIAGKDYGMGSSRDWAAKGTKLLGIKAVIAKSFERIHRSNLVMMGVIPLEFKDGEDAESLGLTGKETYDIDWPDKLVPGQDIRVIATDESNGKKEFMTKLRFDSQDDIDDYRFGGILNKVLDKKVR
>UniRef50_B7QCA1(14-853:853) RNA-binding translational regulator IRP, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7QCA1_IXOSC  E=0 s/c=1.15 id=52% cov=94%
-----------TLVVDGEECRYFSLPEL--GDPRYGRLPFSIRVLLESAVRNCDGFQVEQKDVERLLDWQQQQREGVEVAFKPARVLLQDFTQQMRIIFDACIEDAVHRLGGDPRKINPLCPSDLVVDHSVQVDFSRTADALERNQDLEFERNRERFQFLKWGSQALHNMRIVPPGSGIVHQVNLEFLGQVVFCR----DGLLYPDSLVGADSHTTMINGLGVLGWGVGGIEAEAVMLGQATSMLLPEVVGYRLSGTLPPMATSTDLVLTITKHLRQVGVVGKFVEFLGPGVAQLSIADRATVSNMCPEYGATVGFFPVDAKTLEYMRQTGGWSCPLD-----------WCNTGLH----RHL------LHP-LSFSTTP-LHSDVTNFFFCFRRNALRIEMYYALHQHDIGrRMSSVNSHVRCHGHVAQRTSVTC--------VAGAGLLAKKAVERGLSVAPHIKTSLSPGSGVVTYYLREAGVVPYLEQLGFHIVGYGCMTCIGNSGPLPEPVAEAIEKGDLVAVGVLSGNRNFEGRVHPHTRANYLASPLLVVAYAIAGTVDIDLHSQPLGQDSQGNAVFLRDIWPSREEIQEVEgKHVLPSMFREVYSKVEHGSKNWQSLSAPESLLYPWDSSSTYIKCPPFFETMEREPRPPEDIKGARVLLLLGDSVTTDHISPAGSIARNSPAARYLAARWLTPREFNSYGARRGNDDVMSRGTFANIRLVNKFLD-KPGPRTLHLPSGEEMDIFDAAERYRQEGVPLVILAGKEYGSGSSRDWAAKGPFLLGVRVVLAESYERIHRSNLVGMGIVPLQYLPGQSAHSLGLTGRETFSVAVGGHLEPGQTVPVQLD----DGRSFQALLRFDTAVELAYFRHGGILPYVLRQML-
>UniRef50_Q2KXP1(12-894:905) Aconitate hydratase n=7 Tax=Bacteria RepID=Q2KXP1_BORA1   E=0 s/c=1.04 id=46% cov=98%
-------SMIQSFSCRGRVLRYADLSAAAHAEGrDIRTYPYVIRVLLENLLRHRAwGAAVSEAEISRLWDWGKHI--GADLPLHVARVILPDSSGLPVLQDLAALRDAVAQAGGDAAQVDTRIPVDLIVDHSLQVDYWGDSGAVQRNLRREFERNDERYRFLKWAQQAYKGLRVITPGIGIIHQVNLEYLAPVVAHQTRPDGEWAYPDFVIGGDSHTPMVNALGVLGWGVGGIDAEAALLGHAYTFPIPEVVGVRLHGAIQALTT--DAALLVTQQLRAAGVVGSMVEFFGPAVAALAVPERATIANMAPEYGATCGFFPIDARTLDYARMTGRDEAQLALIEDYARANQLWRDTAQAApAYSRVIDIDLSAARLSLAGPRRPQDRMDVADVAADFRRRLGAPQS---EGGFEVDMGLAAGRDVVGHGSVALAAITSCTNTSNPSVMLAAGLIARKALDRGLTPPAWVKRSLAPGSRAVTRYLESAGLLTALQAQGFHVIGYGCTTCGGKSGPLDAGVAEAIVEGGLVAAAVLSGNRNFEGRIHKLLRANYIGSPAMVVLYALAGRIDVDFEREPLGPGADGAPVYLRDVWPSQEEImALMPLASDPALFAEVYDPASLDSAIWRDLAAPAGLRFPWDPDSQYLVEPPFFKTEPGrdaLADLAAGLARGRVLAAFGDSLTTDHISPSGEIPADTPAGSYLIAKGVAPRDFNTYVARRCNHHVMTRATFANIRIKNALTPGMEGGVTRHYPSGRLMPIVDAATAYRDAGEACIILGGKDYGMGSSRDWAAKGSALLGVRAVIAESFERIHRANLVGMGVLPLAFAPGQGWRQLGLTGAQTLRLENVANGVLKGEPIDVIAEDGSRQVRFQAYAQVLTHAERKLMAEGGIPASVLNAFL-
>UniRef50_C3NJ01(1-855:859) Aconitate hydratase domain protein n=11 Tax=Sulfolobus RepID=C3NJ01_SULIN  E=0 s/c=0.99 id=43% cov=93%
--------------------------------YNLDNLPYVSKIIIENVIAH-NINDIDNKLVNNLLKW----EVGEEIPLYPNRIVMQDYTGIPVIADLTALRDVAKNLGLDVKKISPMVQVDLIIDHSVQVDYFKRNDAIKLNMRREIERNLERFSIIKWAQNSINNLRVIPPGNGIIHEINLEFLSDIVTIDKLNDLKIAHMDFVLGTDSHTTMINGIGVLGWGVGGIEAELVMFNEPYYIKIPEIIGIRLNGKLKHGVTPTDVALYITQQLRKRNLVGKFVEFFGDGLVSLSAFDRATISNMAPEYGVTVAYFPIDSVTLNYYSITNRN---VKLIMEYLRVQNLLYSNNtyhNKLKYQDVIDINLEDVEPSIAGPRYPYERIELSK--------------SKEFIYNNIIGNKKKKGKYIEDGSITLAAITSCTNTANPLSIIIAALLAKNAIKYNLNIPWYVKTSFAPGSKIVEEYLNDLGLLEYLDKLGFNIVAFGCTTCIGNTGPLLKEVEEDIKNNGIITFGVISGNRNFEGRIHPLLNGVFLASPPMVIAYAIAGRIDIQLDREPLGYDNLGNAVYLKDIWPTSNEINEALNKIYNkfNIYHNKIAKiIINSNDNWKEVKSPSGEIFDWSFTKQYIKRPPWFD--EENKHTLNDIVDARVLGLFGDDVTTDHISPAGPIPTNSTIYNYMISQGIKPE--GNLGSYRANHEIYIRSAFLHPKLKNYL-NNKEGGLTLYLPEMKEMTFYEASQEYAKNNIPLIIIAGKRFGMGSSRDTAAKIIRLLNVKAVLAESFERIFRENLVLMGVVPILIPN---WKSLNISGEEKFSIKGLSaQLKPKQDVLIEI-KTEKSIINIKGKISIETEKELKYLAYGGAYNYIKDKIL-
>UniRef50_P82611(42-776:777) Aconitate hydratase, mitochondrial n=219 Tax=root RepID=ACON_CANAL   E=0 s/c=0.96 id=29% cov=77%
---------------------------------------------------------------------------------RPDRVACQDATAQMAILQFMS-------AGIPQVA----TPSTVHCDHLIQAQVGGPKD-----LARAIDLNKEVYDFLSTACAKY-NLGFWKPGSGIIHQIVLE--------------NYAFPGaLLIGTDSHTPNAGGLGQLAIGVGGADAVDVMSGLPWELKAPKIIGVKLTGKMSGWTSPKDIILKLAGITTVKGGTGSIVEYFGSGVDTFSCTGMGTICNMGAEIGATTSVFPFNDSMVDYLNATGRS-EIAQFAQVYKKD---FLSADEGAEYDQVIEIDLNTLEPHINGPFTPDLATPVSKMKETAIANGWP-------------------------LEVKVGLIGSCTNSSYEDMTRAASII-KDAGAHGLKSKAL--YTVSPGSEQVRATIARDGQLKTFEDFGGVVMANACGPCIGQWD------RQDIKKGDKNTI-VSSFNRNFTARNdGNPATHAFVASPEMATVYAISGDLGFNPITDTL-VGADGKEFKLKE----PQGVGLPPDGYDPG--ENTYQAPPEDRASVEVVISPT---------SDRLQKLSPFKPWDG-----KDAERLPILIKAVGKTTTDHISMAG---------PWLKYRGHLENISNNYMIGAINAE------------------NGKANEVRNHYTGKYDGVPQTAAAYRDAGHKWVVIGDENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGLLPLNFKNPADYDKINFD--DEVDLIGLTTLAPGKDVILRVHPKEGEAWEAVLTHTFNSE-QLEWFKHGSALNFI------
>UniRef50_A9V0Y4(181-893:895) Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V0Y4_MONBE   E=0 s/c=0.93 id=29% cov=77%
--------------------------------------------------------------------------------FYPDRVNLQDASAQTALLQFMLTRAPSVS-----------VPTSVHCDHLIV----GSPEGADRDLALAKDQNEEVFSFLESASKRF-GVAFWPPGSGIIHQIVLE--------------NYASPGMLmIGCDSHTPNAGGLGCLAIGVGGADAVEVMSGQPWELLVPKIIGVELKGRLNKWCSAKDIILHLAGQLTVKGGTGHIIEYFGPGTQTLSCTGMATICNMGAEVGATTSIFPYAEPQEAYLRFTGRGA---QADEANAVAHDLLR-ADPGCAYDQVITVDLDQLEPHFNGPFTPDLATPLSAFANQAREKQWPLELSA-------------------------ALIGSCTNSSYEDMTRAASI-AQQAIDKGLTAA--VPFFITPGSEQILQTCRRDGVLDVLERAGGTVLANACGPCIGQW-------SRPTMEDGVPNSILSSFNRNFAGRNdGNKQTHNFLCSPEIVTAMAFSKSLTFNPLTDSL-LAADGTSFKFS---PPEGE------SLSAAGFENNVVKPSAVPEPDLSI------NVSIDPTSTRLQRLDAFAPWDG-----QDFQNLRVLIKVKGKCTTDHIS---------AAGPWLKYKGHLENISQNTLITAVNAEHDRLNS-----VRNYLVDGENYG-----------TIPEVAAAYRDAGVQWIIVGDENYGEGSAREHAAMQPRFLGCVAVVCRSFARIHETNLKRQGVFPLTFADPNDYDQLCSS-----DIVDLIGLRPGEAPALRVRRSEQEEEfTVPLRHTL-SPIQMDWIRSGSALNYIAQTI--
>UniRef50_B2VXW9(45-896:899) Aconitate hydratase, mitochondrial n=3 Tax=cellular organisms RepID=B2VXW9_PYRTR  E=0 s/c=0.77 id=30% cov=78%
---------------------------------------------------------------------------------RPDRVACQDATAQMAILQFMS-------AGLPSVA----TPTTVHCDHLIEAQVGGEKDLARAN-----EINKEVYNFLSTSCAKY-NIGFWKPGSGIIHQIVLE--------------NYAFPGaLLIGTDSHTPNAGGLGMAAIGVGGADAVDVMAGLPWELKAPKVIGVKLTGKLSGWTAPKDIILKVAGILTVKGGTGAIVEYHGPGTESLSCTGMATICNMGAEIGATTSVFPFNDRMYDYLAATKRRD-----IGDFSREYASQLREDEGAQYDELIEINLDELEPHINGPFTPDLATPISKFKEAVKANNWPEELK-------------------------VGLIGSCTNSSYEDMSRAASI-AEDAMAHGVKAKSL--FTVTPGSEQIRATIARDGQLKTFEEFGGMVLANACGPvtlddgqdenalatgsttnlndapdaimpydgrCMpidrdivddydtpttssamgtddGTSDSTAPYGTRDAPinldvhdyntptagysfgfdgvsdftlmddlastmaspltcgasdvdgqwdrkdvKKGQANSIISSYNRNFTGRNDANPAtHSFVTSPDLVVAMTIAGTLNFNPLTDEL-TGADGKKFKLKE--PTGAGLP--ANGYDPG--QDTYQAPPEDRA---------SVSVAVSPTSDRLQLLSPFSAWDG-----KDAKNLPILIKCQGKTTTDHISMAG---------PWLKYRGHLDNISNNMLIGAINAE------------------NGEANKVKNALNGEYGAVPDVARDYKKNGVPWVVIGDWNYGEGSSREHAALEPRHLGGAAIITRSFARIHETNLKKQGMLPLTFSDPADYDKIG--PNDRVDLA-STELAPGKPLTMTVHPADGSKEFQIKLSHTFNEGQIEWFKNGSALNTMAKN---
>UniRef50_C6H6S0(69-729:731) Aconitase n=1 Tax=Ajellomyces capsulatus H143 RepID=C6H6S0_AJECH   E=0 s/c=0.97 id=27% cov=73%
----------------GRSNFYgFSRSAPVEPNGLLTKLSAPYRKMAENLDIVRSRLNRPLTYAEKIMYSHLDDPHGQDIQrgksylkLRPDRVACQDATAQMAILQFMS--------AGMPSV---ATPTTVHCDHLIEAQLGGEKDLARAN-----EINKEVYDFLASSCAKY-NIGFWKPGSGIIHQILLE--------------NYAFPgGLMIGTDSHTPNGGGLGMAAIGVGGADAVDVMAGLPWELKAPNVIGVKLTGQLSGWTAPKDIILKVAGILTVKGGTGAIIEYHGPGVESLSCTGMGTICNMGAEIGATTSVFPFNDRMYDYLKATRR-----QHIGDFARSYAHGLREDEGAEYDQLIEINLSELEPHINGPFTPDLATPISKFKDAVKEHGWPEELK-------------------------VGLIGSCTNSSYEDMSRAASI-AQDALDHGIKAKSL--FTVTPGSEQIRATIERDGQLQTLEEFGGVILANACGPCIGQWDRRD-------VKKGEANSIISSYNRNFTGRNDANPAtHAFVTSPDLVVAMTIAGTLNFNPLTDTL-KGKDGKEFKLK-------------------------------GTNW--------------------CRPP----------------------------------------------------------------------------------------------VKNFKTGEYGPVPATARDYKARGIPWVVIGDWNYGEGSSREHAALEPRHLGGLAIITRSFARIHETNLKKQGMLPLTFTDPADYD--KIQPNDIVDLM-CTELAVGKPMTLRVHPKDGKSFDISLSHTF-NESQIQWFKDGSALNTMAKQ---
>UniRef50_D1Z8H1(49-720:723) Whole genome shotgun sequence assembly, scaffold_9 n=1 Tax=Sordaria macrospora RepID=D1Z8H1_SORMA  E=1e-179 s/c=0.94 id=30% cov=70%
---------------------------------------------------------------------------------RPDRVACQDATAQMAILQFMS--------AGMPSVAN---PTTVHCDHLIEAQIGGEKD-----LERAVNINKEVYDFLASACAKY-NIGFWKPGSGIIHQILLE--------------NYAFPgGLLIGTDSHTPNAAGLG------------------------PKVIGVKLTGALNGWTTPKDVILKLAGILTVKGGTGSIVEYYGEGAEALSCTGKATCGNMGAEIGATTSVFPYDKAMFDYLVATKRSE-----IAEFAKVYQKELRADEGAEYDQHIEINLNELEPHINGPFTPDLATPISKFAQAAKDNNWPEELK-------------------------VGLIGSCTNSSYEDMTRAASI-ARDALNHGLK-------------------AKAAFVLQTFEEFGGTVLANACGPCIGQWDRRDTP-------KGTPNSILSSYNRNFTGRNdGNPATHSFVTSPDLVVAMSIAGSLSFNPLTDTL-KDKDGKEFKL---------------------------------------QAPTGAGLPergYDPGQNTYQAPP----ADRTTVQVQDATDMPILIKAQGKTTTDHISMAG---------PWLKYRGHLDNISNNMLIGAIN------------------AANGEANKVQNFTNGEWGAVPAVARDYKAKGIRWVVVGDWNYGEGSSREHAALEPRHLGGLAIITRSFARIHETNLKKQGMLPLTFSDPADYD--KLSPEDKVDI-LCTELAVGKPITMKVHPKNGKDFEIKLSHTF-NEAQIEWFKNGSALNTMAKN---
>UniRef50_Q4PB22(149-917:1041) Putative uncharacterized protein n=4 Tax=Fungi/Metazoa group RepID=Q4PB22_USTMA  E=1e-177 s/c=0.81 id=28% cov=78%
------------------------------------------------------------------------------------RLAMQDASAQMALLQFMT-------CGLPRTAI----PSSVHCDHLIQAFEGAEAD-----LKRSIASNQEVFAFLESASKKY-GIEFWGPGSGIIHQIVLE--------------NYAAPGLLmLGTDSHTPNASGLGCLAIGVGGADAVDAMTNTPWELMAPKVLGVHLKGELSPWCTPKDVILHLAGKLTVRGGTGKIVEYSGPGLQTLPATGLATMSNMGAEVGATTSAFPFTPAMGSYLEATGRAEVARAAEKA---AGQGFLAADEGAEYDERIEINLSDLEPCLNGPFTPDLSTPLSEFVNKAKSDARDHPVELSA-----------------------ALIGSCTNSSYADMARCAS-LAQQARDRGMKVKS--SFDVTPGSEQVRATVERDGIQQILTDVGGRVLANACGPCIGQWNRKELQGED--------NVILTSFNRNFRGRNDGNSKTwNLLASPEIVTAMAFAGRLDFNPMTDSL-TAPDGKPFKFEapqsDVLPASGFAQGNIDYLPTPM--------PEPQPNTEVLISPTSARLePLEPFSS-----PFAATAAQGKYELP---SMRCLLRIKGKCTTDHIS---------AAGPWLKYKGHLSNLAENTLIGATNDEF------------------DAVNVAQDYETGKQDTIPGVAKLYKSRQQPWMMVADHNYGEGSAREHAALQPRFYGCNLIVARSIARIAETNLRKQGVLTLLFENEDDYLKIG-SGDLVETVNLTDLIRPGGDlstqVKLKVTKFEQDGKTVKETFELATkhslsAAHLDWIRAGSALNLIREQ---
>UniRef50_B2W1R9(33-742:758) Aconitate hydratase, mitochondrial n=2 Tax=Leotiomyceta RepID=B2W1R9_PYRTR  E=1e-166 s/c=0.83 id=28% cov=76%
-------------------------AKLLSRLEEVRRVLGSSRqlTLAEKIL--YSHLESPEESLLSNTNGGRDVRGQANLKLKPDRVAMQDASAQMALLQFMS-------CGLPSTAV----PASIHCDHLIVGEKGADTD-----LPQSITGNKEIFDFLESAAKKY-GIEFWPPGAGIIHQSVLE--------------NYSAPGlMMLGTDSHSPNAGGLGAIVIGVGGADAVDALVDAPWELKAPKILGVKLTGELSGWASPKDVILKLAGHLTVRGGTGFIIEYFGPGVQTLSCTGMATICNMGAEVGATTSLFPFSPAHIPYLQATHRGPiAEAAAKIAQSPMQQNLLRPDPEAVYDKVIEINLSELEPHINGPFTPDLSTPLSKFKSVVEENGWPKTFGA-------------------------GLIGSCTNSSYQDMTRSEEIV-KQASAAGLK--PRADFFITPGSEQIRATLERDDTLSTFTEAGGTVLANACGipTPSGESFKFAPP-----KGSDLPSAGFADGNPDFmptPGVPDP--------SVEVVVA-----------------------------------------------------------------------------PTSSRLALLDPFPAF-----PDSDFTGLRVLYKVKGQCTTDTIS---------AAGPWLKYKGHLPNISENTL----------------IGAVNAQTDEVN---VAYDIDGKTSSIPELAKRWRDQGVEWLVVAEHNYGEGSAREHAALQPRYLGGRIILAKSFARIHETNLKKQGIVPLTFANEADYD-LFAACDEVATRGLLDVLRSGgkGEVELVLKKKDGSEKFIKTKHTL-SHDQCGFVLAGSALNLLARK---
>UniRef50_Q1AS92(20-643:660) Aconitase n=6 Tax=Bacteria RepID=Q1AS92_RUBXD   E=1e-149 s/c=0.85 id=29% cov=70%
-------------------------------------------------------------------------EPGEEVALRIDQTLLQDATGTMACLQFERM-------GVDRVRVPFAVQY---VDHNiIQLDH----------------KNPDDHRFLQAFAARY-GIHYSRPGNGICHYLHVERFARPGA-------------TLIGADSHTTSSGALGSIAIGAGGLDVALVMAGQPFQTPAPKVVGVELTGELSDWVTPKDVILELLRRRGVRGGLNRIFEFYGEGVATIDVTGRTTICNMIAELGATTGIFPSDERTREWLEAQQRPDDFVELA------------ADEGASYDEHEHIALDELEPLIAKPHSPGNVVKVEEVAGTKAA---------------------------------QVCIGSSVNSGFDDLAVAAAVLRDQIVYPGLV------MTVTPGSRQILDSIARTGVYSDLVLAGARMLEPVCGPCVGMG-----------QAPPSDSVSVRTFNRNFPGRSGTMNDHVYLTTPTVAAATALKGVI-----TDPRELGDYPELPKA----PANPEVDDRQIL------------DPAPPEEAEGIEIPRGPN----------------IKPPPEAPELPESLECTVTIVVGDDISTGDLAPDGV----------------------EVMAYRSNIPEIARFTFR-----------------RFDPE-----YHEKAQRMA----PGFIVGGHNYGQGSSREHAALAPLHLGIRAVLAKSFARIHRRNLISQGILPLRFRDEDDYE--RFEQGQRWELPEIRERLERGDEEVPLRSEGGEDVTLLAEF---SPREREILLSGGVLRMLRRK---
>UniRef50_D2VQI0(71-700:703) Homoacontiase n=1 Tax=Naegleria gruberi RepID=D2VQI0_NAEGR   E=1e-142 s/c=0.80 id=28% cov=61%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAGRGIGHQVMIE-------------EGYAWPLTFtTASDSHSNMYGGIGCLGTPVVRTDAAAIWATGSTWWQVPPVTRVELTGKLREGVSGKDVIITLCGIFNQDDVLNHCVEFVGEGVSSLSIDERLSIANMTTEWGALAGVFPVDEKTIDWLKKSQKSEKANDIKE--LENNYKKYLPDSDAKYVQTLTLDLGSVEPHVSGPNHVKVMSSVREITK-------------------------------KNIKVHKAYIVSCVNSRVNDLHQAANVIRKSSK---KTIAEGVELYISAASDKVQKESERLGDWQVLVQAGAKVLPPGCGPCIGLGAGLLEDG----------QVGISSTNRNFKGRMGSRNAEAYLASPEVVMASALSGVITL------------------------------------PEYYTESQAPLPKFTK--------TSENQSEGEKST-----------TKIIEGFPEVIEGEVVFVHQDNLNTDGIYP----------GKYTYKENISPEEQ------------------AQVAMENYDVNFT-----------------------KIAKKGHVLIAGYNFGTGSSREQAATCLKFMGIKLIVGGSFSETYKRNATNNGFLCIEVPALVDYLKQSVgTTKETVLLENSKISIDfrNSTLVLTTPKETKEYSFHPVG-----PVAQELIVSGGLEPLVLNKI--
>UniRef50_C0WBH9(127-597:598) 3-isopropylmalate dehydratase large subunit n=2 Tax=Clostridiales RepID=C0WBH9_9FIRM  E=1e-115 s/c=0.89 id=26% cov=51%
----------KTVSANGKSFPVGAIPqnllEIVEHGGLVEDTKAKIKagykapelpVMSDASLRR--KGFTLAEKILRKNAGVEEVKPGDIVVTHPDFLMIHDIY-TPYLLD--TLHEMGTKEIDDPDKVC------IVFDHCM-------PTAVAKNDSAHYDAG------LKLAEE--YGIKKLHIGEGICHSLMHEKF-------------YAKPGEVQsATDSHTTTYGGAGCFCSGIGTAEMAAALTTGELWFKVPSAIKVVLNGHFPKGVFSKDIILRILGDITASGAQYKSLEFTGPAAREMSLDARFTVANMALEAGAKCGLFEADEKTAAYY---GIPLSEID-----------WIRIDDEAQYEKVLTYDVSTLEPQLSCPQGVDNVYPISEVLGT---------------------------------PMDEVYIGSCTNGSLEDLKAAADIL------RGKKVANHVRVIVVPATNTVFKEAIEKGYIKDFIEAGCVISHPCCGLCCGMPYGLMYDDERIL----------LTANRNFIGRQGTKKTLGYLSSPAVAAATALTGVV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0NKK5(34-651:700) Aconitate hydratase, putative n=2 Tax=Eukaryota RepID=D0NKK5_PHYIN   E=1e-113 s/c=0.67 id=24% cov=58%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVGADSHSCSTGGLGAFAIGLGAADVVMPLVTGETWIKVPETVLIEFVGTPPMGMGGKDVMLYTLGQLKCNTVaIGRCVEWGGN-ISALSCDARFAISNMTAEFGGIAGVFPADERTAAYISK--RPDHNQDA---------LYFRADEDAQYAEKFQIDLDNLEPQVALFPSPDNVKPVSEVVG---------------------------------MKLDGCFIGACT-TAEEDLVLGA-LVLEACLKQGMTPVAHGQRRVTPGSQIIVDNLKKHGLIDVYEKAGFIVGAPGCSFCLGIAADVAGENEVWL----------SSQNRNYRNRMGKGSIAN-LASAITVAASSFTMEV-----TDPRPFLKLIDVEKFNSAVPKQPAVPITIAEVDPEL-----------------------------PTAAAEEAGNADAEAAASLDTFSGSIQGRV-QVFGDNIDTDAILP----------GEFLCE-----NDMEALGKVAFLH--------TNPDFRGKVKQGQD-----------------------------VVVAGHGFGCGSSREQAVTAMKGAGVKALIARSFGYIFSRNYQNFSLLGIQLDDDRFYELAK----ENVDI----------TVNMTGRTIEVGGETFCFNMSLF---EERLLAGGGIMP--------
>UniRef50_D2LMX6(28-431:432) Homoaconitate hydratase family protein n=3 Tax=Aciduliprofundum boonei T469 RepID=D2LMX6_9EURY  E=1e-110 s/c=1.00 id=28% cov=33%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGADSHTCTSGALGAFATGMGSTDVAIAFALGKVWLRVPETHRFYIEGKFPKGVYSKDLILHIIGTIGADGATYKSMEFYGPTIDKMSMESRFTITNMAIEAGGKTGMIAPDATTKKYLEEMGRGEKYREI------------KSDDDAWFEKEYEFNVDELEPTVSFPHTVDNTRTISEAKKM-------------------------------NIRIDQVYIGTCTNGRIEDLRVAAKIL------DGNKVNKKTRLIVIPASRRVYIQALKEGLLEKFVEAGAAIESPGCGPCVGIHKGVLADGERVL----------STQNRNFKGRMGNPNAEIYLGSPATAAATAIEGKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8S1K9(102-735:740) Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC BAA-613 RepID=A8S1K9_9CLOT  E=1e-110 s/c=0.63 id=22% cov=66%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGSDSHTR-YGCLGTMGIGEGGTEIARQALGSTYDIRRPPVIAVKLSGAPVPGVGPMDVALTLIGAVFDCGFcKNKILEVVGDGIANLSMEYRMGIDVMTTETAALSSIWMTDETVREWLAIHGREDAYEKL------------EPTGDALYDGLIEIDLSSMEPMIALPFHPSNVYSIRELCRDRAYLDGVLESVEKDAYMRSGLTYTLRDKiKNKRLMVQQASIAGCAGGTFDNIAAVADILDGYKIS-----GDGISLGIYPASQPVFLETMRQGVAERLLLSGVTIRPCICGPCFG---------TVDVPANNTLGIRHVS--RNYYSREGSKTDSGQLSATALMDARSIASTVRNGGL---LTAATEMDTVYRK-----------FDYHFENTIYRGGvYNGFGCPNP---CIHVPKGPN---------IKDWPDFSEMRK-------HVLLKAAACFEGSITTDELCPSGEASSLRSNPEKIAAYTLISKDQE-YVEYAGN-------------IRDALENENTG--TRSVLE-QVCTMLGSEMKDISYGSLLI---SDKIGDGSSREQAASNQKVLGGWANLAIEYStKRYRSNCISWGLIPLSCKERPDLKK----GDYLLLPDASGKIRMGEEQLEGIILKTGEKVRLSIGEM--TEEERRMLVLGGMINY-------
>UniRef50_A3LRP7(91-638:677) 3-isopropylmalate dehydratase (Aconitase superfamily) n=1 Tax=Pichia stipitis RepID=A3LRP7_PICST  E=1e-109 s/c=0.72 id=25% cov=57%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGADSHTCSSGALGCLAVGLGTSDVVFPLITGETFFQIPETLKIEIVGKPNFGIGGKDTILHILKEFKRNTiASNRAVEYDGQGLQYLSCDARFAISNMSTEFGALAGVFVPDQQTSAFI---NRRKNPI------FKRDSLYFRPDEGANYVEVREINLGEVVPYIALFPSPDNVVPVTEKLG---------------------------------MELDGCFVGACT-TAEEDLILGA-LVLKAGLESGLKVSERGHRRVTPGSLVLIARLKEFGLLQWYEKAGFAVGAPGCSYCVGMGADQAAPGEVWL----------SSQNRNFENRMGKG---------------SIANLASSSTVAASSFSMKVTDPSYLLD-RVDRNEYDKYRLFWKDSQESIMYSEPKE--------IAPEKVT----------RLMAYKEELSELPEVIKSR-----VQRFDDDVDTDAIIPIDKMGKDDLA----------------------------TSAFAYVR------------------PDFVKKVHEGAK---------IIVAGRGFGSGSSRETAPEALKLCGVQAVIAKSFAYIYNRNQANISLFGIRVADEGFYKAA----------------QEGETVEILVKSRQVQVNGTTYAFQLDN-LELKLQSSGGLL---------
>UniRef50_C1F700(18-472:475) 3-isopropylmalate dehydratase large subunit n=250 Tax=cellular organisms RepID=LEUC_ACIC5  E=1e-108 s/c=0.87 id=26% cov=35%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIVCGDSHTSTHGAFGALAFGIGTSEVEHVMATQCLPQGRPKTFRISVEGELPEGVTAKDIVLGIIGRIGTDGATGYVIEYAGSAIRSLSMEGRMTVCNMSIEAGARAGMIAPDETTFAYLKD--REYSPKGKAWDEAVAAWSELKTDEGATFDRELVIPAIELTPYVTWGTNPGMVIPITD--EIPGPETAASEADQRGIERALEYMGLKPGTPMEEVAIDVVFIGSCTNSRIEDLRAAAKVVT------GYRVNEKVRAMVVPGSHRVKEQAEREGLDRIFREAGFEWREPGCSMCLGMNPDILTPGER----------CASTSNRNFEGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5CSH5(10-465:473) 3-isopropylmalate dehydratase large subunit n=70 Tax=cellular organisms RepID=LEUC_VARPS  E=1e-103 s/c=0.83 id=27% cov=35%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVVCGDSHTSTHGAFGALAHGIGTSEVEHVMATQTLLGKKAKNMLVKVEGKLPFGCTAKDIVLAIIGKIGTAGGTGYTIEFAGSAIRDLSMEGRMTVCNMAIEAGARAGLVAVDEKTIGYIK--GRPLAPTGVEWDQAVAYWRTLQSDPDAAFDAVVELDATQIQPQVTWGTSPEMVVDIN--GRVPDPDKEKDASKRSAIERALVYMGLEPNKAMNDIFIDKVFIGSCTNSRIEDMREAAAVVKKL----GQKVAKNVKLaMVVPGSGVVKEQAEREGLDVIFKAAGFEWREPGCSMCLAMNADRLEPGER----------CASTSNRNFEGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0NYA4(44-666:711) 3-isopropylmalate dehydratase large subunit, putative n=2 Tax=Peronosporales RepID=D0NYA4_PHYIN  E=1e-102 s/c=0.60 id=22% cov=60%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIGADSHTCSAGGMGAFAAGLGAGDVVMPLVTGQTWFKVPEVCYIEFVGAPSFGIGGKDVILHILGELKRNTVAfERAVYYGGAGLKYLSDDARFAVANMSTEFGGIAGVFQADTITQRVLEAR-----------ESHFDEALFFEPDEGCNYAAHHVINLADVKPLIALYPSPDNCVSVQEKLG---------------------------------MKLDGCFIGACTTTQ-EDLILGAMVL-QQAMLEGKRPSANGNRRVTPGSLEIVDRLKELGLVRIYEEAGFTVGVPSCSFCVGIGADVAGEGEVWL----------SSQNRNFRNRMGKGSIGNLSSAAVVAAS-------SFDMEvVDPLP--------YLDKI--NKDDFDRYRNWVEPDSSTPSPAKTTKSYT----VTEPEPVLASGNDEVTVQQAKEQAAVAELEAALPPKFSGK--VQKFGDNIDTDAVIPAQFMGLNKSSPLW-------PAECET------ELDVLAAKSFAYVR-------------------------PEFPQK-VKEGLN-IIVAGTAFGSGSSREEAAICLKAVGVQAVIAKSFAYIYARNQPNNALLGIVVTDEKFHELA----------------AEGEEVTVDLRNRVVSVKDHQVAFSL-TQLEEAFLNGGGL----------
>UniRef50_C7Z416(77-692:692) Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7Z416_NECH7  E=1e-102 s/c=0.61 id=28% cov=49%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAGRGIGHQIMIE-------------EGYAWPGSLaVASDSHSNIYGGIGCLGTPVVRTDAAAIWSTERTWWQIPPIAKITLTGLLPPGVTGKDVIVALCGLFNKDEVLNHAIEFAGSdqTMHSIPIDDRLTISNMTTEYG-----------------------------------QGLVSQDGP---------------------------------------------------------------------------CLVSCTNSRASDLAAAARVFREAAKEgKSAKVAPGVKFYVAAASILEQKIAEEAGDWDVLREAGAEFLPSGCGPCIGLGTGLLEEGEVGISA----------SNRNFKGRMGSPLAKAYLASPEIVAASAIQGKIAG-----PGWYQKPEGVEKVIIGEGSGDHVADKALSIEDAL-----DKIIAEAESMIAVAEKDGSGAEAETAA------PASEAEGEGEETLTDIIPGFPEKIEGEIVFCD----ADNINRWHLSGEQMSEVCMENYDPEFRNTARA---------------------------------------------------GDILVAGFNFGCGSSREQAATAILAKEIPLVVSGSFGNIFSRNSINNALLGVEVP--------------------------------------------------------------------------
>UniRef50_Q15S62(25-466:467) 3-isopropylmalate dehydratase, large subunit n=4 Tax=Proteobacteria RepID=Q15S62_PSEA6  E=1e-102 s/c=0.85 id=28% cov=38%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLVCPDSHTCSQGALGALAWGIGSSEAEHALATKTLRVSKPKTMRVNFHGEMGFGVSAKDMILHLIGTYGAAGGAGYVIEFAGSAVEALEIEGRLTLCNMAVEFSAFSGLVAPDEKAITYLK--GREYAPKGELWQQAVTYWQSLFSDEQAQFDKTIEIDCADISPTITWGNSPQHACSVN--SRVPSAQADATQNQLKALKRAYEYMDVQPGSALKGLPIGAAFIGSCTNSRISDLRLAAKVL------KGRKVADNVNAICVPGSTTVKRQAEAEGLDKIFIAAGFEWREAGCSMCFFAGG----------ESFGYRQRVVTSTNRNFESRQGPETRS-HLASPATVAASAIAG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8LQF5(2-452:464) 3-isopropylmalate dehydratase, large subunit n=2 Tax=Rhodobacteraceae RepID=A8LQF5_DINSH  E=1e-100 s/c=0.82 id=27% cov=36%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSHTSTHGAFGALAFGIGATEVAHVLATQTVWQTRPKTLRLRFDGRLGPGVGAKDLALAWIAALGSDGARGHAIEYTGEAVRRLSMEGRMTLCNLSIEGGAKLGLIAPDETTFAYLR--GRPHAPDGADWGRAVEDWAALRSDEDAVFDREETLDCAAIAPVVTWGTRPDQAIPVTE---------NLPRGEGSEVNSALTYMGLRAGAPIAGTPVDQVFIGSCTNGRIEDLRAAAAVLA------GRR--ARVPGQVTPGSARIKAQAEQEGLAEIFIAAGLEWTEAGCAMCVGMNGDLVAPGKR----------CASSTNRNFRGRQGPGART-HLMSPAMVAAAAVTGEI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q3IRQ4(107-466:474) 3-isopropylmalate dehydratase large subunit n=29 Tax=cellular organisms RepID=LEUC_NATPD  E=1e-100 s/c=1.02 id=27% cov=38%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIVCGDSHTSTHGAFGALAFGIGTSQIRDVLATQTIAMEKKDVRKIEVTGELGEGVTAKDIILTIIRRLGTDGGVGYVYEYAGEAIENLGMEGRMSICNMSIEGGARAGYVNPDETTYEWLRETDAFADDPERFEE-LKPYWESVRSDPDAEYDDVVTIDGSEIEPVVTWGTTPGQGIGITE---EIPAPEDLPADKQDTARRAQDHMGVEPGETMAGYNIDVAFLGSCTNARLPDLRSAAEII------KGREVHDSVRAMVVPGSQRVKAAAEDEGLDSVFKEAGFDWREAGCSMCLGMNDDQLVGDE----------ACASSSNRNFVGRQGSKDGRTVLMSPEMVAAAAVTGEV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A2SQ03(17-410:417) 3-isopropylmalate dehydratase n=5 Tax=Methanomicrobiales RepID=A2SQ03_METLZ  E=1e-96 s/c=0.91 id=29% cov=34%
----------------------------------------------------------------------------------------------------------------NKSVVNPE-KLSIIYDHispannSVTADLQGDLRKFSRQNGMHF---HEV-------------------GCGICHQIMSE--------------GVCLPGeIVVGADSHSCTLGALGAFSTGVGATDMAGIWATGGTWFRVPESISIVLSGKLSGHTEPKDVALSYVKALGMDGGTYKALEFIGDGAAGMPVEGRLTLSNMAVETGAKTGLFYADALTREHLITYGADEKTISLQKP------------EDCSYESEIYLDLDDIEPLLAIPHRVDNAVPVTEYSGT---------------------------------QIDQVFMGTCTNGRFEDLKRFAEIV------RGKKVA--VRTIVTPASKDAYAKALSTGVLSDILEAGCVICPPGCGPCLG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q94AR8(66-507:509) 3-isopropylmalate dehydratase n=45 Tax=cellular organisms RepID=LEUC_ARATH  E=3e-95 s/c=0.80 id=28% cov=34%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLGTDSHTCTAGAFGQFATGIGNTDAGFVLGTGKILLKVPPTMRFILDGEMPSYLQAKDLILQIIGEISVAGATYKTMEFSGTTIESLSMEERMTLCNMVVEAGGKNGVIPPDATTLNYVE--NRTSVPFEPVY-----------SDGNASFVADYRFDVSKLEPVVAKPHSPDNR---------------------------------ALARECKDVKIDRVYIGSCTGGKTEDFMAAAKLFH----AAGRKVK--VPTFLVPATQKVWMDvyalpvpgAGGKTCAQIFEEAGCDTPAsPSCGACLGGPAD-------TYARLNEPQVCVSTTNRNFPGRMGHKEGQIYLASPYTAAASALTGRV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6FCI8(19-467:468) Isopropylmalate isomerase large subunit n=2 Tax=Bacteria RepID=A6FCI8_9GAMM  E=3e-95 s/c=0.78 id=25% cov=38%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLVCCDSHTTTHGAFGALAFGIGTSQVEHVLATQTLRAIPFNTMRVNVTGAYNEGVDAKDLALFIINEIGTGGGQGCVIEYTGEAVSQLSMEQRMTLCNMTVEAGASAGIISPDQTTVSYLKE--KLAERNVTISDADTTKWLTYATDMDAVFDKYVEIDAAKVPKMISWGTNPSQVIPV--VGKVPYVDPLDCASKQIAATQALKYMGLKEGDDLSSHPITNVFIGSCTNGRIEDMRAVAAVLKEH------KVHKDVHMLIVPGSMKVHEQVIKEGIDKVFLNAGADFRGlAGCSLCVGLNSDKLSAGKRT----------VSTSNRNFEGRQGVGVRT-HITSPVVAAASAIKGHI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A3JVQ2(19-453:459) Isopropylmalate isomerase large subunit n=4 Tax=Rhodobacterales RepID=A3JVQ2_9RHOB  E=2e-90 s/c=0.77 id=27% cov=37%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSHTTTYGAYGALGFGIGTSEVEHVLATQTLRYKRMKTMRVLIEGDTAPGVTAKDIIMKVVQVVGAGGANGFAVEFAGSATQNLDMAGRMTVCNMAVELGARAALIAADEITETALQGHSHSGRFTYNGESW--------HSDLEAVFDKEVTIAGGDIEPLITWGTSPDQSVPIT--AQVPVASDYVTPKAKAALARSLNYMGLTEGQSAQSIEIDTAFIGSCTNSRIEDLREAAKILT------GRHVAAGVEAIVVPGSAMTRLKAEAEGLREIFEAAGFEWRPeAGCSMCLAMNDDIAMDGERVA----------SSTNRNFEGRQG-RGARTHLMSPAMVAAAAIAGHL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0PU56(1-260:260) Iron-responsive element-binding protein 2 (Fragment) n=5 Tax=cellular organisms RepID=C0PU56_SALSA  E=8e-83 s/c=1.20 id=45% cov=29%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PESVVFPWDPKSTYIRSPSFFNKLCKEVQPPQSIENAHALLFLGDKVTTDHISPAGSIARVSAAARYLLSKRLTPREFNSYGARRGNDAVMTRGTFASIKLQNRFI-GKPGPKTVHIPSGQTLDVFEAVERYQRDGVPLIILAGKQYGSGNSRDWAAKGPYLLGVRAVIAESFEKMHKNHLVGMGIAPLQFLPGQSADSLELCGKEKFTITLPEDLSPKQMLTV----KTSSGKTFSVTTLFDNEMDVAFYRHGGLLRYVARTML-
>UniRef50_P37032(9-889:891) Aconitate hydratase n=121 Tax=Bacteria RepID=ACON_LEGPH   E=0 s/c=1.26 id=67% cov=99%
-------STKSQLTVDGKTYNYYSLKEAEnKHFKGINRLPYSLKVLLENLLRFEDGNTVTTKDIKAIADWLHNKTSQHEIAFRPTRVLMQDFTGVPAVVDLAAMRTAIVKMGGNADKISPLSPVDLVIDHSVMVDKFASADALEVNTKIEIERNKERYEFLRWGQKAFSNFQVVPPGTGICHQVNLEYLGKTVWNSENDGQLYAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPVSMLIPEVIGFKLSGKLKEGITATDLVLTVTQMLRKKGVVGKFVEFYGPGLNDLPLADRATISNMAPEYGATCGFFPVDKETIKYLELTGRDKHTIALVEAYAKAQGMWYDKDnEEPVFTDSLHLDLGSVEPSLAGPKRPQDKVNLSSLPVEF---NNFLIEVGKEKEKEKTFAVKNKDFQMKHGHVVIAAITSCTNTSNPSVLMAAGLVAKKAIEKGLQRKPWVKSSLAPGSKVVTDYLRHAGLQTYLDQLGFNLVGYGCTTCIGNSGPLPDDISHCVAEHDLVVSSVLSGNRNFEGRVHPQVRANWLASPPLVVAYALCGTTCSDLSREPIGQDKEGNDVYLKDIWPSNEEIAAEVAKVSGTMFRKEYAEVFKGDAHWQAIQTSSGQTYEWNPDSTYIQHPPFFENLSLKPEPLKPIKQAYVLALFGDSITTDHISPAGSIKASSPAGLYLKSKGVDEKDFNSYGSRRGNHEVMMRGTFANIRIRNEMTPGQEGGVTRYVPTGETMSIYDAAMRYQENQQDLVIIAGKEYGTGSSRDWAAKGTNLLGVKAVITESFERIHRSNLIGMGILPLQFKEGTTRKTLKLDGSERISIEISDKLTPGAMVPVTIERQDGDIEKIETLCRIDTADELEYYKNGGILQYVLRKI--
>UniRef50_Q4UK20(1-876:878) Aconitate hydratase n=18 Tax=Proteobacteria RepID=ACON_RICFE   E=0 s/c=1.22 id=58% cov=98%
MSKVHNSEYIKELSVDNTSYKIYDINKAASDIElPLKKLPYSLRVLFENVLRS----NGSKQNLLVFKEWLKTKESDAEIDFMPARVLMQDFTGVPAIVDLAAMRDAMKKIGGDPLKINPLIPVDLVIDHSVSVDSYAAKDSFDKNVQMEMKRNIERYQFLKWGQQAFNNFKVVPPGTGICHQVNLEYLAKVVWHK----DGLAYPDSLVGTDSHTTMVNGLSVLGWGVGGIEAEAAMLGQPLTMILPEVIGVKLTGKLTGIATATDLVLTVTEMLRKKKVVGKFVEFFGEGLKNLTIADRATISNMSPEYGATCGFFPIDQETIKYLELTGREKTQIKLVEKYANEQNLWYDFEHEAEYTEILELDLSMVHSSLAGPRRPQDRVDLNDVANNFK--HELPNFGIENKDIDKKYAVANQNYEIGNGDVVIAAITSCTNTSNPSVMIGAALLAKKALEHGLKVKPWVKTSLAPGSKVVTEYLKLSGLDKYLDELGFNLVGYGCTTCIGNSGPLNPEIEETINKNGLVVASVLSGNRNFEGRINPLTKASYLGSPILVVAYALSGTLNIDLNNQPI-----GKNIYLKDIWPSKEEIDEViANSINSSMFIEKYSDIFSGTKEWKDLQITTSSTYNWNKNSTYINNPPYFEDI-GSKNNIKDIKSAKILAIFGDSITTDHISPAGSISKTSPAAKYLTDNHIEPLDFNSYGSRRGNHEVMMRGTFANIRIKNEMCKGVEGGFTINQLSSTQQTIYDAAMDYKANDVPVVIFAGKEYGSGSSRDWAAKGPQLLGVKAVIAESFERIHRSNLVGMGILPLTFTGNNTRLDLKLDGSETIDIIGLSEqIKPYNPVKCMIKKQTGETRTIDLILQIFTDNEINYIKHGSIMHFVVENL--
>UniRef50_Q90875(7-888:889) Cytoplasmic aconitate hydratase n=13 Tax=Euteleostomi RepID=ACOC_CHICK  E=0 s/c=1.19 id=51% cov=97%
------------LDAKEPVKKFFNLSKLED--VRYARLPFSIRVLLEAAIRNCDEFLVKKQDVENILNWKVMQHKNVEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPICPADLVIDHSIQVDFNRRSDSLQKNQDLEFERNKERFEFLKWGSQAFKNMRIIPPGSGIIHQVNLEYLARVVM----DQDGYYYPDSVVGTDSHTTMVDGLGVLGWGVGGIEAEAVMLGQPISMVLPEVVGYKLLGNPQPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAYFPVDDISIGYLVQTGRDKEKVLCTKKYLEAVGMlrdFKNSSQDPDFTQVVELDLHTVVPCCSGPKRPQDKVAVSDMKKDFETCLGAKQGfkgfqiAPDRHNSVIKFNFEGCDFELAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVEAGLTVKPYIKTSLSPGSGVVTYYLRESGVMSYLSQLGFDVVGYGCMTCIGNSGPLPDSVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTVRIDFEKEPLGISASGKKIFLKDIWPTRNEIQAVERqYVIPGMFKEVYQKIETVNEAWNALDAPSDKLYTWNPKSTYIKSPPFFDGLTLALQTPKTIEDAYVLLNFGDSVTTDHISPAGNIARNSPAARYLTSRGLTPREFNSYGSRRGNDAVMARGTFANIRLVNKFID-KQGPQTIHFPSGETLDVFDAAERYKQAGHPLIVLAGKEYGAGSSRDWAAKGPFLLGVKAVLAESYERIHRSNLVGMGVIPLQYLPGEDARTLGLTGRERYTIIIPENLKPQMNIQIKLD----TGKTFHAIMRFDTDVELTYFHNGGILNYMIRKM--
>UniRef50_C6V584(11-897:905) Aconitate hydratase 1 n=2 Tax=Neorickettsia RepID=C6V584_NEORI   E=0 s/c=1.12 id=54% cov=96%
---------------------YFDIKLEES----VTSLPCVIKILIENALRNRQ-----KDSIVRALCHYKQHIGNLAVDYYPSRVLMQDFTGVPAIVDLAALRDAVSEAQGDPRSVNPKIPVDLVIDHSIQVDSYGKASSATENKTIEFQKNIERYKLLKWAQKSFQNFRVVPPGTGICHQVNLEYLAQVVRTERQETEVLAYPDTLVGTDSHTTMSGGLSVLGWGVGGIEAESVVLGEPISMVIPEVIGLKLEGKLKAGLTATDLVLHITHLLRKHKVVGKFVEVFGDGVKNLSVADRATIANMAPECGSTCNFFAPDQKTLDYLDLTGKTQEQIDLVEDYTKSQTMWADYARATDFVDVIELDLSEVRTTLAGPKRPQDKISLHLVPENFNKVCTRSEKKVETSPAPDEECVQIPQTsvgigadspKLQNGSIVIAAITSCTNTSNPSGMIAAGLLAKRAVQSGLQVKNWVKTSLAPGSQVVSEYLKQSGLQDYLDQLGFNIVGFGCTTCIGNSGELKEEISEEIDEKDLVVVSVLSGNRNFEGRIHPKVKANYLASPMLVVAYGIAGNININLESQPLGYDKTGKAVYLRDITPSDDEIDAYVHRFlRKEIFLSKYQDVFLGDRNWQQLECTSSVTYKWDENCTYIKSPPFFksdgqvsfqdiipkinEKVDHQPAAFDiSVRDARILAVFGDSITTDHISPAGTIPVKSPAGEYLKTLGVTPQQFNSYGARRGNHEIMIRGTFANTRIKNKMLENVEGGYTTHFNRDgrrEIVSIYEAAMRYKSSGTNLVIFAGKEYGTGSSRDWAAKGTYLLGVKAVIAESFERIHRSNLVGMGVLPLVYSDPEEYGRLTLTGEEIVTIELEGDPSPMCKMECQIINKTGLTERLALTLMVTTEKEMGYIKVGNILKYVLK----
>UniRef50_A2RIZ0(2-847:848) Aconitate hydratase n=7 Tax=cellular organisms RepID=A2RIZ0_LACLM   E=0 s/c=1.16 id=54% cov=95%
----------KTLKINDKEYHYFDISETER----IEDFPYSLRVLLESLIRQKNDKNIDQAYIQAIKDYLKR-EVGQETVFLPSRVVLQDFTGVPAIVDLAAMRDAMLKLGKNPELINPEIPVDLVIDHSVQVDFQGNEQAFLLNSKKEFERNRERYEFLKWAEQSFDNFRVVPPATGIIHQVNIEYLSEVISEN----DGLLYPDSVFGTDSHTTMINALGVLGWGVGGIEAEAVMLGEPSSLTVPEVVGVRLIGKLGVFATATDLALTVTKILRDEKVVGKFVEFFGEGLKNLSLADRATIANMAPEYGATCGYFPIDNETLKYLRATNRSEEIVARVEAYAKANKLFYDDSYQPHYSKVIDINLEKVETRLSGPSRPQDMLELGDLSHNFE-----------------KFVEQQKKLKEEDGKIAIAAITSCTNTSNPHVMMMAGLLAKNAVEQGLEVPSWVKTSLAPGSKVVSSYLDKAGLLPYLETLGFNVIGYGCTTCIGNSGPLLREMEKEITDKELVATSVLSGNRNFEGRIHPLVKANYLASPPLVVAYALAGSVRKNLTKNPLGTNLKGEKVYLKDILPPSDEVDDLVQKyVTKDLYAKTYAKIFDENTIWNDIQTKKSQVYNWKTDSTYISNPPYFDDMTLVATNKNILSNLQVLAKFGDFITTDHISPAGNIPLKSPAGDYLRNSGITYKDFNSFGSRRGNDKVMTRGTFANIRIKNQLVAPLEGGYSKFA--DEILPIYEVAQKYKEKGAGLIVLAGKDYGMGSSRDWAAKGTKLLGVKAVIAESFERIHRSNLVMMGILPLQFLDDQNAKSLGLTGDEVFSIDLPVHPKIHEKITVQ-----ADEKKFQVLLRFDSQVDLDYYTNDGIMPYVIRK---
>UniRef50_C7MM28(26-944:946) Aconitate hydratase 1 n=3 Tax=Coriobacteriaceae RepID=C7MM28_CRYCD   E=0 s/c=1.04 id=50% cov=98%
-----------TLTVADKHYTYWPVSSVSHA----NRLPYSLRILMENILRCAPTNEARKQSAQRIIEAAAAHSVGEEVEFSPARVLFQDFTGVPVFVDFAVMREACKQLGGDPAQINPHVPCDLVIDHSVIADEFGCAGALNQNTALEFTRNRERYAFLKWAQRSFQNVRIVPPGQGICHQLNIERFATVATVRSADDNPVpatttqvpesnpataratesnlapvaatqstkskdallpsdssldpgVFFDTLVGTDSHTPTANGIGVLGWGVGGIEAEAAALGQPITILVPQVVGVRFTGSLSEGVSAMDLSLHMAALLRAEGVVGCFVECFGPGVAHLSATQRTCISNMTPEYGCTCTLFPVDDRTLDYLRVTGRSSDQVELVEAYAKAQGLW-NSDAVRDYAKVLEVDLSQVERGIAGPSRPHEHIAWSEVPQTIARINE----QRGLDKQCVTVELDGKAHQIGQGALAIAAITSCTTATDPAMMLACGLLARNAVHKQLHPKPWVKTILAPGSKATELLLERAGLVDSLRELGFYTCGFGCMSCIGNSGPILEPLHAIASQVEL--ASVLSGNRNFEGRISPDVSQNYLSAPAGVVAYALAGRIDFDFEHEPLGQDSAGHDVFLCDIWPSDDEVAMLQKHiVNQALFNDGAQGLYEGDTSWRQLEAAESDLFSWDSTSTYVRRAPYFDGMQRTLEAPVPIRGARVLALLGDFITTDHISPAGSIAADSAAARLLREAGVASQDFNTYGARRGNHEVMMRGTFANVKLKNSLAEGRLGGWTRDHIDGQVKLIFDAAQHYRTEGIPTVVIAGKMYGSGSSRDWAAKGPALLGVRAVIAQSFERIHRSNLVGMGILPLQFEEGQSASSLGLTGTEVFDIAPIDFSAGMpnpAEVAVTAQRTNGEVVRFNALVRIDTPTEGAYFRSGGILAYVLRNLM-
>UniRef50_P48200(16-962:963) Iron-responsive element-binding protein 2 n=74 Tax=Eukaryota RepID=IREB2_HUMAN  E=0 s/c=0.99 id=47% cov=97%
-------------TLNDSSHkKFFDVSKL---GTKYDVLPYSIRVLLEAAVRNCDGFLMKKEDVMNILDW-KTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPACPTDLTVDHSLQIDFSKcaiqnapnpgggdlqkagklsplkvqpkklpcrgqttcrgscdsgelgrnsgtfssqientpilcpfhlqpvpEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQINLEYLSRVVFEEKD----LLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNssgEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGfkgfqiAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGKNIYLHDIWPSREEVHRVEEEHVIlSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFI-GKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRETFSLTFPEELSPG----ITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVARKF--
>UniRef50_D2TUF5(12-881:882) Putative aconitate hydratase n=2 Tax=Bacteria RepID=D2TUF5_CITRO   E=0 s/c=1.07 id=42% cov=97%
------------LVVNNQRYDYLDLTQLLPS-GQLQKIPFCLRVLLENVARRSPHALTP------FLRMLDGASDKGEVAFYPDRLMFHDTTCLPALADFAAMRDLTTELGGDATAINPRIPAVLTIDHSVIVESYASPSALEDNLRYDFRRNAERYRFIRWAEKSLNNFRVIPPGTGIIHLMNLEAIAEVVTVDEAAPVPLLHADCMIATDSHTPMINALGILGWGVGGLEGQAALVGEPVTLSFPDVIGISLSGALPHDVNDSDLALHITRLLREIGVVGKFVEFTGPALHAIPVESRATIANMAPEYGATVVYFPFDERSAEYVALTGRTEEKQSLIKAYMQAQHLWRSADsPQPEFSQLIEIDLTTIEPCMAGPVNPHQQIPLGQAAASFEETLNAQTRG-------LCWRHPAYGEPIRQGAVAIAAITSCTTTANPWLIVQAALFARNAAKAGLKPKPWVKTSFSPGSRAVTDYLGEAGLLSELEKVGFDVTGYGCMTCIGSSGALQPAMEELVNE-GLQAVCVLSGNRNFPRRVNPSLGHGYLTSPALVIAWAIAGHMSHDMVNEPLGVDRNGSPVTMRDLMPARDEVEMWLKRvVKREHYVKRRDIIWQGTPHWQQVEAPGSVHYPWEASSTYLRRPGYLERLPRDPATPLSLSGARPFLWLGDDVTTDHISPAGAIPPSSLAGQWLLDHHEDPADLNLYSTRRSNHEVMVRGAFTNKALANRLLPSElrgGGGNAWDARHSHILPAYEAAQSWLKEGTPLVIFAGERYGAGSSRDWAAKAQALLGVKAVVAYSFERIHRTNLIGMGILPLHIDPEHAAHLPAMTGTEVIDFYGLENLQPGtMPLSMRISRHGALLQELPLTLTLDSQQELRYLQHGGILPYVIQQTLK
>UniRef50_B9NWS1(8-862:863) Aconitate hydratase 1 n=1 Tax=Rhodobacteraceae bacterium KLH11 RepID=B9NWS1_9RHOB  E=0 s/c=1.00 id=46% cov=96%
----------ETLDVAGRQVGVRSLSRAV--GAPLSKLPYVLRVLAENAL-------APEADPDDLSCIL--MREGDMIEFRPSRLILQDMLALPLLLDLMLLREVARDRGAHKNATDLTLPIDLVIDHSMTVEHWASPDALAENQRHEFEVNRERFAFFKTCEAEFAALRVIPPGGGIMHQVNLEYLSQVAELVGPSQAPILQADTVLGTDSHTPMVNGLGVLGWGIGGLDAERITLGHRLALNVPEVVGLRLHGALPDSATATDIALLVTRVLREVGVVGAFVELCSDGYASLSVPDRATIANMAPEYGCTCVYCPIDKNTLGYLRMTGRSASHVARVEAWARHQALWRDPSAEAkiDYDRIVDLDLSRIGHSVAGPARPEQHVALASVPQRLS------------DLPNVRHPVPGCDFDLGNDDVIIAAITSCTNTANPRNMVTAGLIARNAVRRGLRVKTWVKTSLSPGSRVVAAYLRDSGLQADLDRLGFHVAGFACTTCNGMSGPLDPAIEKTIQKHDLDCAAVLSGNRNFAGRIHPLAAKNILAAPPLVVAYALAGSLATDIAAGVLGFDQKDRAVRLDDLWPDQADVDAILDAYAgPDTYRGVYANVADVSEEWNALTA--DGAFRWPEGSTYISRPPYLDGMSNIPEPMRKIEGLRPLVVLGDNITTDHISPSGYIPTDSAAGHYLSSRGVAERDFNSFGTRRGSNDIVVRSTFSSIRLVNEMVAGREGPWTRIFPSGRKASVFDAIEHYLAENTPLIVIAGKRYGAGSSRDTAAKAPKLAGVQAVLAESFERIHRSNLVNMGIAPLVFPEGVTRRTLRLDGSETFDLEFNEAL---DAAQLTIHRRNAQTEVQSLRIALFNTAERKTFQHGGALQESARALV-
>UniRef50_Q99798(47-777:780) Aconitate hydratase, mitochondrial n=199 Tax=root RepID=ACON_HUMAN   E=0 s/c=0.94 id=30% cov=77%
---------------------------------------------------------------------------------RPDRVAMQDATAQMAMLQFIS-------SGLSKVAV----PSTIHCDHLIEAQVGGEKD-----LRRAKDINQEVYNFLATAGAKY-GVGFWKPGSGIIHQIILE--------------NYAYPGvLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRED-----IANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGKVAEKEGWP-------------------------LDIRVGLIGSCTNSSYEDMGRSAA-VAKQALAHGLKCKS--QFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWD------RKDIKKGEKNTI-VTSYNRNFTGRNDaNPETHAFVTSPEIVTALAIAGTLKFNPETDYL-TGTDGKKFRLEA--PDADELPK--GEFDPG--QDTYQHPPKDS---------SGQHVDVSPTSQRLQLLEPFDKWDG-----KDLEDLQILIKVKGKCTTDHIS---------AAGPWLKFRGHLDNISNNLLIGAINIE------------------NGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYN--KIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTF-NETQIEWFRAGSALNRM------
>UniRef50_C0NGE0(392-1171:1174) Aconitate hydratase n=5 Tax=Onygenales RepID=C0NGE0_AJECG   E=0 s/c=0.85 id=27% cov=79%
----------------------------------------------------------------------ENIRGQANLKLKPDRVAMQDASAQMALLQFMT-------CGLPSTAV----PASIHCDHMIVGEKGADVD-----LPASIKGNKEVFDFLESAAKKY-GIEFWPPGAGIIHQTVLE--------------NYAAPGLLmLGTDSHTPNGGGLGAIAIGVGGADAVDALVDAPWELKAPKVLGVKLEGKLSGWTAPKDIILHLAGKLTVRGGTGYIIEYYGPGVESLSCTGMATICNMGAEVGATTSLFPFSPSMVPYLRATNRGNIADAATAIASSGPQNLLRTDTGAEYDQHITINLSTLEPHINGPFTPDLSTPLSAFAGKVREKQWPETFGA-------------------------GLIGSCTNSSYED-MTRAEDLVKQASEAGLKPKAD--FFITPGSEQIRATLDRDQTLATFSAAGGTVLANACGPCIGQW------KRTDGVKKGESNAILTSYNRNFRGRNDGNTATmNFLASPEIVTAMSYAGRTTFNPMTDSLPT-PSGKPFRFR----------------PPTGFDLPKSGFESGNPDFQPTIAAPSPSCPvvVSPTSDRLALLEPF-----SPFPPHNLTSLRVLYKVKGQCTTDTIS---------AAGPWLKYKGHLPNISANTLIGAIN-------------------AATGETNVAYDTDGSTYSIPELAAKWKAAGTEWLVVAEENYGEGSAREHAALQPRYLGGRIIAAKSFARIHETNLKKQGVVPLTFKDKADYD--RIDACDAVDTVGLYEVlisggQADEEVRLRVTKNGsGEVFEIPMKHTL-SKDQCGFILAGSALNLLAKK---
>UniRef50_Q0CSK9(78-777:781) Aconitate hydratase, mitochondrial n=3 Tax=Leotiomyceta RepID=Q0CSK9_ASPTN  E=0 s/c=0.93 id=29% cov=74%
---------------------------------------------------------------------------------RPDRVACQDATAQMAILQFMS--------AGMPSV---ATPTTVHCDHLIEAQVGGEKDLARAN-----EINKEVYDFLATATAKY-NIGFWKPGSGIIHQIVLE--------------NYAFPgGLMIGTDSHTPNAGGLAMAAIGVGGADAVDVMAGLPWELKAPKVIGVKLTGEMSGWTTPKDIILKVAGLLTVKGGTGAIIEYHGPGVNSLSCTGMGTICNMGAEIGATTSMFPFNDRMYDYLKATKR-----QHIGEFARSYAKELREDEGADSRRL-------LMPTV-GP-----------------------------------------------EELKVGLIGSCTNSSYEDMSRAASI-ARDALNHGVKSKSL--FTVTPGSEQIRATIERDGQLQTLEEFGGVILANACGPCIGQWDRKD-------VKKGEPNSIISSYNRNFTGRNDANPAtHAFVASPDLVVAMCVAGTLKFNPLTDTV-KDKDGKEFKLAP--PSGDGLPSKGY----DAGRNTYQAPPQDRA---------SINVAVSPTSDRLQLLAGFEAWDG-----KDATGIPILIKCQGKTTTDHISMAG---------PWLKYRGHLDNISNNMLIGAVNAE------------------NGEANKVKNKFTGEYGAVPATARDYKARGVKWVVIGDWNYGEGSSREHAALEPRHLGGLAIITRSFARIHETNLKKQGMLPLTFADPADYD--KIQPEDTVDL-LCTELEVGKPMTLRVHPKNGSTFDVKLNHTF-NESQIEWFKDGSALNTMARK---
>UniRef50_A2R842(39-786:792) Contig An16c0190, complete genome n=94 Tax=cellular organisms RepID=A2R842_ASPNC  E=1e-179 s/c=0.84 id=28% cov=78%
---------------------------------------------------------------------------------RPDRVACHDATATMALLQFIS-------AGLPRVMV----PTTVHSDHLII-----SENGAEKDMQRATTEHAEVYDFLSSASKKY-GIGFWKPGSGIIHTVIFE--------------NYAMPgGLIIGTDSHTPNAGGMGMLGIGVGGADAVDAMSGMAWELVAPKVIGVELTGELQGWASTKDIICKLAGILSVSGGKGRIIEFFGPGTKTLGATAMATICNMSAEIGSTSCIFPYSDAIARYLSATAR--DHVVKAANSVKDLLLTADEGSEEYYDEIIKIDLDTLEPHVNGPFTPDLAHPISKLSTAVAESDWPVNLSH-------------------------AMVGSCTNSSYEDLDK-ARQLVNQARAAGIT-KFKTPFLVSPGSERIRATAEEAGILQDLEDAGAMILSSSCGPCVGSWDRKDVDVR-----GKEKNSVISSYNRNFVGRHDSNPAtHSFVTSPELVTAFAYAGRLDFNPVTDSI-SAEGSQPLRLTP--PVGQEL--------PESFNSGADRFQEPPSDGSSYSVI------IDEKSDRLQLLKPFPAWKHGNAT-----DMELLMKVKGKCTTDHISPAG---------PWYKYRGHLENISHNMLT-----------TATNAFLDN---DPQMLGHTTHPLTRKVQLTHEVARDLKHRSIRWCVVGDNNYGEGSSREHAALEPRFLGGIAIIARSFARIHETNLKKQGMLPLTFADPADYD--RVQEGDRITLIGVEdgELQPGKNVTMRVTPRHGDAWEAELCHS-YHAGQLPWLRAGSALNHI------
>UniRef50_C3Y932(20-682:685) Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3Y932_BRAFL  E=1e-168 s/c=0.90 id=30% cov=70%
---------------------------------------------------------------------------------RPDRVAMQDATAQMAMLQFIS-------SGLPKVAV----PSTIHCDHLIEAQIGGDKD-----LTRAKDINKEVYNFLQTAAAKY-GVGFWKPGSGIIHQIVLE--------------NYAFPGvMLIGTDSHTPNGGGLGGVCVGVGGADAVDVMAGIPWELKCPKVIGVKLTGEISGWTSPKDVILKVADILTVKGGTGAIVEYHGPGVDSISCTGMGTICNMGAEIGATTSIFPYNRRMKDYLVSTGREE-----ISNLADEFSEHLKPDDGCEYDQLIEINLSELKPHINGPFTPDLATPVAEVGERAKKSGWP-------------------------LDIRVGLIGSCTNSSYEDMGRAASI-AKQALDHGVKSKSL--FTVTPGSEQIRATIERDGII--------------------------------------------------------------------VTALSIAGTLDFNPETDEL-TGANGEKFKLES--PFGDELP--AKGFDPG--QDTYQHPPQDG---------TGVAVDVDPKSDRLQLLSPFDKWDG-----KDHEDMAVLIKVRGKCTTDHIS---------AAGPWLKYRGHLDNISNNCFIGAIN------------------IVNGEANNVENVLTGNWGAVPDAARHYKAHGLKWVVVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANPADYD--KVQPSDRISLVGLNNLAPGSQVECILKHADGSQDSIMLNHTF-NEGQIEWFKAGSALNRM------
>UniRef50_D1AK91(18-638:644) Aconitate hydratase n=16 Tax=Bacteria RepID=D1AK91_SEBTE   E=1e-164 s/c=0.94 id=29% cov=69%
-------------------------------------------------------------------------RPGEEICVKVHQTLTQDSTGTMAYLQLNAM---------NADKVKTEVSVAY-IDHNM--------------LQASFE-NADDHEFIKTSAAK-HGIIFSKPGNGICHRLHLEKFGK--------------PGkILIGSDSHTPTGGGLGMIAMGAGGLDVAIGMARGLYYLKAPKVYNVELRGKLQPWVSAKDIILHVLRELTVKGGVGYVIEYTGEGVKYLSVDDRATITNMGAELGATTSIFESNEETLDFLKKQGREEDYIPL------------SADPDAEYDEKLVVNLDELVPLAAFPHSPDNVHEIPE---------------------------------SEKIKVDQIAIGSCTNSSYSDFMKLAKIL------EGKKVHPDVSLVLSPGSSNIMNMISENGALATLIAAGARVLEASCGPCIGMGQAPKSEG-----------ISLRTFNRNFKGRCGTMNAEVYLVSTETAAVSSITG-----YFTDPRTFGADIKVEFPE----------------KYALYDNYYIYPPESDEDRRKTEIIMGPN---------IKPFP-------INKPLEDEFIRKVILKTKDNITTDDICPSNA----------------------KLLPFRSNIPKLSEYCFNTI-------------------------IPDFKER-AENNDGGIVVGGDNYGQGSSREHAALLPLYLGIKAVIAKSFARIHKANLVNAGIIPLEFINAEDYDKI----DEYDELEFKDTKSSLETGVFKILNKTKN-IEFEAGFT-GSEREKKILEYGGYLNF-------
>UniRef50_D2RMM0(22-647:651) Aconitate hydratase n=21 Tax=Bacteria RepID=D2RMM0_ACIFE   E=1e-154 s/c=0.87 id=30% cov=69%
--------------------------------------------------------------------------PGQEIKVTVDQTLTHDINAVMAYLAFEAL---------DLDRVRTKLSVSY-IDH---------------NLLQIDNKTPDDHIYLQSIAQKY-GLVLSKAGNGICHALQCSRFGK--------------PGTlLLGGDSHTPSCGALGMLAIGVGGMDIAVALAGFPYVMKMPKVVKVNLKGRLRPGTAAKDIILEMLRRTTVKGGVGKVYEYVGEGVETLSIPERLTIANMGAEMGATTSVFPADGQVRAFLKAQGREQDYTEWL------------PNAGCGYDEEIQLDLDALEPLVACPHMPDNVMKVADVPK---------------------------------IPVQQVFIGSCTNGSYSDFKKVALVLKEH------KINPDVSLVLGISSRQIYLRLLQDGVIADLVDSGARITEFACGPCCGIG---IAPSSKGI--------SVRTSNRNFKGRSSTADASLYLVSPEVAAATAIKGRLALPQEV--------------------MDDVSVLGTVKEPETYPINDNLFLLPPEDGRDISIVRGPN---------IKPLPVAD-------PPEETLEAKVSLKARDNVSTDDITPASA----------------------QFSSMRSNMPAMAQYAFCRYD-------------------------PDFAKRAQKDGKSFIV-GGENYGQGSSREHAAITPMYLGVKMVIAKSFARIHKGNLINHGVIPAVFVDKAAYDGIDLD--DTFHIDNLRDQMKNKTIEIQNLSK---GNRFTVKLEL-TDQEVEILLAGGKLRF-------
>UniRef50_Q2GN26(75-794:797) Homoaconitase, mitochondrial n=23 Tax=Dikarya RepID=LYS4_CHAGB   E=1e-134 s/c=0.67 id=27% cov=59%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAGRGIGHQIMIE-------------EGYAWPGTLtVASDSHSNMYGGVAALGTPVVRTDAASIWATGQTWWQIPPIAKVTFTGVLPRGVTGKDVIIALCALFNQDEVLNHAIEFTGSdlTLSSLPIDDRLTISNMTTEWGAVAGIFPIDSTLKSWLRAKATVSAMLnpdlggKARITHDKIEELFRDppkPDLGATYAKSLYLNLSTLSPFVAGPNSVKVATPVKDL-------------------------------EAQNIKINKAYLVSCTNSRASDIAAAANVFREAANGGPIpKVAPGVEFYISAASLPEQEIAEQAGDWRVLLDAGCIENPASCNACIGLGRGLLQPGDVGISA----------SNRNWNGRMGSPQAKAYLASPEVVAASALKGEIAGPGWYEkPEGVEKVIIGEGTGDLEADRAvSIADALESLvaQAESMISSAEKSLESSP-----AAATGAVGNAMADATADQAGE--EGLIDILPGFPEKVSGEIVFCDSDNINTDGIYP----------GKYTYQDDIT------------------RDTMAQVVMENYDRSFASL-----------------------AKPGDILVAGFNFGCGSSREQAATAILAKGIPLVVAGSFGNIFSRNSI------------------------------------------------------------------------------------
>UniRef50_P07264(32-706:779) 3-isopropylmalate dehydratase n=577 Tax=cellular organisms RepID=LEUC_YEAST  E=1e-134 s/c=0.71 id=25% cov=60%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLATQTIIQAKSKNMRITVNGKLSPGITSKDLILYIIGLIGTAGGTGCVIEFAGEAIEALSMEARMSMCNMAIEAGARAGMIKPDETTFQYTK--GRPLAPKGAEWEKAVAYWKTLKTDEGAKFDHEINIEAVDVIPTITWGTSPQDALPIT--GSVPDPKNVTDPIKKSGMERALAYMGLEPNTPLKSIKVDKVFIGSCTNGRIEDLRSAAAVV------RGQKLASNIKLaMVVPGSGLVKKQAEAEGLDKIFQEAGFEWREAGCSICLGMNPDILDAYER----------CASTSNRNFEGRQGALSRT-HLMSPAMAAAAGIAGHFVDIREFEYKDQDQSSPKVEVTS--EDEKELESAAYDHAEPVQPEDAPQDIANDEL-KDIPVKSDDT-PAKPSSSGMKP---FLTLEGISAPLDKA-----------NVDTDAIIP---------------------KQFLKTIKRTG----LKKGLFYEWRFRKD-----------DQGKDQETDFVLNVEPWREAEI--LVVTGDNFGCGSSREHAPWALKDFGIKSIIAPSYGDIFYNNSFKNGLLPIRLD--------------------------------------------------------------------------
>UniRef50_Q1IMD4(19-645:655) Homoaconitase n=3 Tax=cellular organisms RepID=Q1IMD4_ACIBL   E=1e-133 s/c=0.76 id=28% cov=60%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTGIGHQIMVER-------------GYVVPESfVVASDSHSNMYGAMGAIGTPVVRTDAAAIWATGEFWWSIPRTIQVVLEGKLRPGVTGKDVIITLAGLYNKDEVLNAALEFAGSGVHTLTMDERLSIANMSTEWGALTGWFPVDQVTISYLRQRhgvARWQGTEKFTEEElLKWARAPLGPDKDATYAAKIELDLAQVTPHVSGPDSVQVMHSVAQM-------------------------------EEKKIAVHKAYLLSCVNSRVSDLEAAAKVLA------GKKIAETVKFYVAPASKHVQEEAEKRGIWKTLVDAGAITLPPSCGPCIGLGTGLLEAGEVGISA----------TNRNFKGRMGSRDARCYLASPEVVAASALAGYITGPVHFE----------------------------HANPNIMLSEYVPAASAAEAVSILE------------------------------GFPASVKGRLVFVPQDNLNTDGI----------------------------YGKDYTYREDMTPEMMAKVVMENYDPEFS-----------------------AKTSAGDVVVGGSNFGTGSSREQAVTALKAKGIPLVIAGSFSQTYLRNAFNNGFLCIE--TPEFVAELKQKFAAQVA-NKKKTIVPGDEVEIDFATSTlkyaGETFTFPALGSVP----QSLVAAGGVENLVAQKL--
>UniRef50_P49367(20-693:693) Homoaconitase, mitochondrial n=21 Tax=Dikarya RepID=LYS4_YEAST   E=1e-129 s/c=0.69 id=28% cov=56%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAGRGIGHQIMIE-------------EGYAFPlNMTVASDSHSNTYGGLGSLGTPIVRTDAAAIWATGQTWWQIPPVAQVELKGQLPQGVSGKDIIVALCGLFNNDQVLNHAIEFTGDSLNALPIDHRLTIANMTTEWGALSGLFPVDKTLIDWYKnrlqklGTNNHPRINPKTIRALEEKAKIPKADKDAHYAKKLIIDLATLTHYVSGPNSVKVSNTVQDLSQ-------------------------------QDIKINKAYLVSCTNSRLSDLQSAADVVCPTGdLNKVNKVAPGVEFYVAAASSEIEADARKSGAWEKLLKAGCIPLPSGCGPCIGLGAGLLEPGEVGISA----------TNRNFKGRMGSKDALAYLASPAVVAASAVLGKISSPAEV------------------LSTSEIP----------FSGVKTEIIENPVVEEEVNAQT----EAPKQSVEI------------LEGFPREFSGELVLCDADNINTDGIYP----------GKYTYQDDVPKEKM------------------AQVCMENYDAEFR----TKVHP-------------------GDIVVSGFNFGTGSSREQAATALLAKGINLVVSGSFGNIFSRNSINNALLTLEIPA-------------------------------------------------------------------------
>UniRef50_D1ZLH5(22-731:733) Whole genome shotgun sequence assembly, scaffold_56 n=1 Tax=Sordaria macrospora RepID=D1ZLH5_SORMA  E=1e-126 s/c=0.64 id=26% cov=58%
-----------------------------------------------------------------------------------------------------------------ASKIHDNRQVVMTLDHDVQ---NKSEANLKKYRQIE--------EFAKT-----HGVDFYPAGRGIGHQIMVE-------------EGYAWPGTVtVASDSHSNMYGGVGCLGTPMVRTDAASIWATGKTWWQIPPIAKVTFTGLLPPGVTGKDVIVALCGLFNNDDVLNHAIEFTGseETMRSIPVDDRLTIANMTTEWGALSGLFPIDNVLTSWM----RAKATVNAME--------------------------------------------------------------HPELGDKAKSPYPLRISKAQNLKLDKAYLVSCTNSRASDIAAAARVFKEAAFnNKGVipKVAEGVKFYIAAASLLEQKQAEDSGDWQVLLDAGAEPLPSGCGPCIGLGTGLLEPGEIGISA----------SNRNFKGRMGSTDAKAYLASPEIVAASALKGKIAGP-------------------GWYQKPEGVEKVIIGEGNGIVEQDKAMSIEDALDKIIAEAESLIaaaEAETTTTESTSTPEGEESLTEILPGFPEKISGEIIFCDADNINTDGIYP----------GKYTYQDNITPSKM------------------AEVCMEN------------YDPSFGSI-----------AKAGDILVTGFNFGCGSSREQAATAILAKQIPLVVSGSFGNIFSRNSI------------------------------------------------------------------------------------
>UniRef50_Q9UT74(57-719:721) Homoaconitase, mitochondrial n=9 Tax=Dikarya RepID=LYS4_SCHPO   E=1e-126 s/c=0.69 id=28% cov=55%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAGRGIGHQIMVE-------------QGYAMPGSMaVASDSHSNTYGGVGCLGTPIVRTDAAAIWATGQTWWQIPPIARVNLVGQLPKGLSGKDIIVSLCGAFNHDEVLNHAIEFYGEGLNSLSIESRLTIANMTTEWGALSGLFPTDEKLLAWYEDRLKflgPNHPRVNRETLDAIKASPILADEGAFYAKHLILDLSTLSPAVSGPNS-------------------------------VKVYNSAATLEKKDILIKKAYLVSCTNGRLSDIHDAAETV------KGKKVADGVEFYVGAASSEVEAAAQKNGDWQTLIDSGARTLPAGCGPCIGLGTGLLKDGEVGISA----------TNRNFKGRMGSREALAYLASPAVVAASAIAGKI-----VAPEGFKNAVSLVSAVDIT----------------------DKVNKQTASKSSTEAVDSETAIID--------------------GFPSIVAGEIVFCDADNLNTDGIYP----------GRYTYRDDITKEEM------------------AKVCMENYDSEFG-----------------------KKTKKDDILVSGFNFGTGSSREQAATAILSRGIPLVVGGSFSDIFKRNSINNALLAIQLPD-------------------------------------------------------------------------
>UniRef50_B8MG01(258-797:896) Aconitase, mitochondrial, putative n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8MG01_TALSN  E=1e-111 s/c=0.75 id=28% cov=54%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQPGMLViGADSHTCSGGSVSCLAVGMGATDVIMPLVTGQTWLTVPETVHLRLINEPPFGVGGKDTVLYILKTFKRNTiAADRIVEFSGPGLAALSCDARFAIANMCTEFGAVSGIFAADDRTLDFVNRRR---------IRKHKNNAIYFQPDEDAIYAQSFEIDLSKVESGVAIYPSPDNVVPASEVVGT---------------------------------ALDGCFIGACTTT--EEDLIMAGLVLEAGLKKGLKPVDHGRRIVVPGSKPIRHKLEKLGLIEIYKQCGFKVGVPGCSMCVGQGVDQAAAGEKWL----------SSQNRNFKNRMGPGSIANLASAAtvaassfsmQMSNPRELLDMIDRDRLKEYLGFEPSAQI----SLVSGKSEMNT-----STLIFSEPYGRDENTSNSAEgGIPNTSGNALFADEGlSTAIQ--------------------GKVL-RLGDFVDTDAIIPSKFLASSR---------------------------------------TNEELGSHCMEFFMPEFRQLVRDGHD------------VVVAGRAFGCGSSRDVAVNALLGAGVKCVIAESFSFIYSRNQPNIGLLGIVIKD-------------------------------------------------------------------------
>UniRef50_B8GY66(8-467:479) 3-isopropylmalate dehydratase large subunit n=15 Tax=Proteobacteria RepID=LEUC_CAUCN  E=1e-105 s/c=0.84 id=24% cov=38%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLRQKKAKNMLVRVDGQLPPGVTGKDVALAVIGEIGTAGGTGYVIEFAGEAIAGLSMEGRMTLCNLTIEGGAKAGLVAPDDKTFAYIQ--GKPAAPKGAAWDMALSHWKTFFTDEDAVFDRTVVIDGSALVPMVTWGTSPEDVIPVT--GNVPDPESFATPDKRAAAHRALDYMGLKAGQPISEARIDRVFIGSCTNSRIEDMRAAAAVV-QEAFLHGRLVAPHVKAMVVPGSGLVKEQAEEEGLDAIFKAAGFDWREPGCSMCLAMNPDKLAPQER----------CASTSNRNFEGRQG-RAGRTHLVSPAMAAAAAIAGHL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2V844(2-420:431) 3-isopropylmalate dehydratase large subunit n=172 Tax=cellular organisms RepID=LEUC_SULSY  E=1e-105 s/c=0.92 id=25% cov=34%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLVIGADSHTCTYGGIGAFSTGVGSTDIAYIWATGETWLRVPESMKFVFYNKPQKWVGGKDFVLTVIGKIGVDGALYKAMEYQGEAIRALDIDNRLTIANMAIEAGGKSGIIEPDEKTVDWVRkRTNREFK--------------LYKSDPDAKYCCEYEFDASKIEPVVACPSLPSNVKPVSEVAGTH---------------------------------IDQVFIGSCTNGRLSDLRIAAAIL------KSKKVHPEVRCIVIPASDQIYKQALHEGIIEILADAGCLISTSTCGPCLGGHMGILAEGE----------VCLSTSNRNFVGRMGHPKSQVYLSSPAVAAASAVLGRIAH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6XJA5(3-468:482) 3-isopropylmalate dehydratase, large subunit n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XJA5_HIRBI  E=1e-102 s/c=0.81 id=28% cov=38%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLVCPDSHTCTQGAFGALAWGIGSTEAEHVLATATLRMKRPKDMRINITGTLSEGVTAKDLALYIVSKLGSAGAKGHIIEFAGEAVSGLNMEARMTLCNMATELSAFTAIVSPDDKSLTYLKD--RPFSPKGEDWDRASEYWLSLKSDAEAEFDTSFQFDASQIGPMVTWGNSPQHAISISEEIPEFESLK--LGDGRETYDRAIQYMGLTGIKKLKELSIDGAFIGSCTNSRISDLRRAAAVL------KGQTIAANVRAICVPGSTQVKREAEAEGLDEIFRESGFEWRESGCSMCFFAGGESFGPRERVI----------SSTNRNFESRQGLNTRT-HIASPEIVAASAIAGRI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C9K7I3(248-799:843) Aconitase family protein n=2 Tax=Alternaria alternata RepID=C9K7I3_ALTAL  E=8e-99 s/c=0.66 id=24% cov=55%
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGMLVlGSDSHTCSAGAVSALAIGLGAGDVMAGLATGETWFKVPECIRINFTGQPAWYIGGKDVILSVLKQLKRNTyAAERIVEFGGAGAKLLSCDARFAISNMCtvrdpndrPELKPTA-----DD------RSTSRNlvllQAFLFPTVSLNRLSIAAGARYEGASYASTFEIDLGEVEPFIAIYPSPDQVCPVAERTG---------------------------------MRFDGCFIGACT-TTEEDLVLAA-LVLEAGLKRGLTL-EKGKRIVVPGSLPIVKNLRALGLLDIYKACGYEQPAPGCSLCLGIGADVAEAGSQWL----------SSQNRNFQNRMG-RGAVGHICSAATVAASSFNMTL-----TDP------------CDLLNDVSETTFKEYLARCKVARGGSESKLAGGKQANNVQYIEPCLLGENARSAEGEVPALEAAAVSLDDARLGSINSRI-YKLDDYVDTDAlpqIIPA-PACVGSPTDEMLGSHCfeLTNPDFRDYV--RSGHR--------------------------------------------------VIVGGRAFGCGSSREEAPRALKGLGVQCVIARSFAFIFGRNMPNIGMLAIVLTDE------------------------------------------------------------------------
>UniRef50_B2TDH6(319-645:655) 3-isopropylmalate dehydratase n=5 Tax=Burkholderiales RepID=B2TDH6_BURPP  E=1e-87 s/c=1.00 id=29% cov=34%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGTDSHTPHSGALGCLAFGAGATEIANSWVTGYVRCKVPETLRIEISGQLRDGVTAKDVVLHLLQMdaIRSGGAIGLVFEYGGSAVRAMSIDERATLTNMVAELGGFTGIVEPDERTVAFLKERRGVDFTLEN----------WMKSDAGATYRDTISIDASAIQPMLARPGDPGNGVPALQLE--------------------------------QDVAIDIAYGGSCTAGKREDFDFYHEVLHW-GVEQGLRVPEGTRLYLQFGTMAVRAYCEERGYLPVFERAGVTLVMPGCGSCANCGPGQSAEANE---------VTISAINRNFPGRSGP--GNVWLASPYTVAASALAGKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4VXS4(11-435:439) 3-isopropylmalate dehydratase large subunit n=4 Tax=Streptococcus suis RepID=A4VXS4_STRSY  E=1e-86 s/c=0.76 id=26% cov=29%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSHTATHGAFGAIAFGIGTSEVEHVLATQTIWQVKPKRLLVEFVGQAQRGVYAKDFILALIARYGVDCGLGHVVEFAGPVIDRLSMEERMTICNMSIEFGSKMGIMAPDQTTFDYLR--GRECAPADFDAAVADWKELY--SDADTVYDKHLVLDVSDLAPMVTWGTTPAMGVSFDETFPSIRDHNDERVYA---------YMDLAPGQKAADIPVGYVFLGSCTNARLSDLQLAARIV------KGRKIAEQVTAIVVPGSRPVKRAAEKLGLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q7N5S3(12-410:413) Similar to large subunit of 3-isopropylmalate dehydratase n=1 Tax=Photorhabdus luminescens subsp. laumondii RepID=Q7N5S3_PHOLL  E=4e-82 s/c=0.77 id=25% cov=32%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIGADSHTCTGGAVQSLALGMGASDVLAAMLTGQTWLKVPETVSLSISGQPHPATRTKDVMLALLRHFGQSPFLYRSVELCGEWSQTLSLDSAASFASMGVELGAKC-VFMPD--------GPGRPANMRPINPEVV---------------DHHLTFLLSELTPHISLPHSPAQSVPLETLSGQ---------------------------------KIDYVFIGSCTNSRLEDIAEVAAILDKH------RVHQDVHCIVTPGSKRVYLEAMRRGYIEKIVSAGALVTPPGCGACVGTQGTIPAKGERVL----------STMNRNFQGRMGNAEAEIYLSSPLVAANVALHGRV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q6GH55(1-899:901) Aconitate hydratase n=155 Tax=cellular organisms RepID=ACON_STAAR   E=0 s/c=1.19 id=55% cov=100%
MAANFKEQSKKHFDLNGQSYTYYDLKAVeEQGITKVSKLPYSIRVLLESLLRQEDDFVITDDHIKALSQFGKDGNEG-EVPFKPSRVILQDFTGVPAVVDLASLRKAMDDVGGDITKINPEVPVDLVIDHSVQVDSYANPEALERNMKLEFERNYERYQFLNWATKAFDNYNAVPPATGIVHQVNLEYLASVVHVRDVDGEKTAFPDTLVGTDSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPIPEVIGVRLVNSLPQGATATDLALRVTQELRKKGVVGKFVEFFGPGVQHLPLADRATIANMAPEYGATCGFFPVDDESLKYMKLTGRSDEHIALVKEYLKQNHMFFDvEKEDPNYTDVIELDLSTVEASLSGPKRPQDLIFLSDMKSSFENSVTAPAGnqghgldKSEFDKKAEINFKDGSKATMKTGDIAIAAITSCTNTSNPYVMLGAGLVAKKAVEKGLKVPEYVKTSLAPGSKVVTGYLRGAGLQPYLDDLGFNLVGYGCTTCIGNSGPLLPEIEKAIADEDLLVTSVLSGNRNFEGRIHPLVKANYLASPQLVVAYALAGSVDIDLQNEPIGKGNDGEDVYLKDIWPSIKEVSDTVDSvVTPELFIEEYNNVYNNNELWNEIDVTDQPLYDFDPNSTYIQNPSFFQGLSKEPGTIVPLNGLRVMGKFGDSVTTDHISPAGAIGKDTPAGKYLQDHQVPIREFNSYGSRRGNHEVMVRGTFANIRIKNQLAPGTEGGFTTYWPTNEVMPIFDAAMKYKEDGTGLVVLAGNDYGMGSSRDWAAKGTNLLGVKTVIAQSYERIHRSNLVMMGVLPLEFKKGESADSLGLDGTEEISVNIDENVQPHDYVKVTAKKQDGDLVEFDAMVRFDSLVEMDYYRHGGILQMVLRNKL-
>UniRef50_Q5ZLQ4(24-965:965) Iron-responsive element-binding protein 2 n=5 Tax=Amniota RepID=IREB2_CHICK  E=0 s/c=0.99 id=47% cov=96%
--------------------RFYNVSKLGGTKYDV--LPYSIRVLFESSIRNCDGFLVKETDAMNILDW-KTKQNDVEVPFCPARVVLQDFTGIPAMVDFAAMREAVRNAGGDPVKVNPACPTDLTVDHSLQIDFSKcaiqnapnpgggeaqkptaklsplkgqprklpcrgqssckgpcsagelsrasgqfsaqientpilcpfhlqpvpEPETVLKNQEMEFGRNRERLQFFKWSSKVFKNTSIIPPETGMAHQVNLEYLSRVVF----DVEDFLYPDSVVGTDSHTTMVNGLGILGWGVGGIETEAVMLGMPVTLTLPEVVGCELTGTASPLATSIDIVLGITKHLRQAEVAGKFVEFFGSGVSQLSVADRTTIANMCPEYGAILSFFPVDNVTLKHLRHTGFDEAKLEVMEAYLKAVKLFRNgesSSREPEYSQVVQISLSSIIPHVSGPKRSQDRVAVNNMKSDFQTCLNEKAGvkgfqiAAEKQNDVVPVQYEGNQYELSHGCVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLEVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEVVGYGCSTCVGNTAPLPEAIRNAIKQGDIIACGVLSGTKNFEGRLCDCVRANYLASPPLVVAYAIAGTVRIDFETEPLGTGFNGRSIYLRDIWPTRKELHTVEEEcVISSMFKELKEKMEKGNKRWNSLEAPESPLFPWDLKSTYIRCPSFFDKLAKEPVSLQPIENAHVLLYLGDSVTTDHISPAGSIARSSAAAKYLTNKGLTPREFNSYGARRGNDAVMTRGTFANIKLLNKFI-GKPAPKTIHFPSGQTLDVFEAAELYQKEGIPVIILAGKKYGLGSSRDWAAKGPFLLGVKAVLAESYEKVHKSQLIGIGIAPLQFLPGENPNTLGLTGREQFSILFPPELSPKMTLDI----KTSTGKVFSVFALFENDVEITLYKNGGSLNFVARRFL-
>UniRef50_Q125M5(11-869:888) Aconitase n=15 Tax=Proteobacteria RepID=Q125M5_POLSJ   E=0 s/c=1.01 id=45% cov=96%
-----------QLFVNGQAHALVDLPALC--GERLGRLPVVLRLLLENAVRNMQGDE-RQAAVDAVFAWLEHGTSEAELAFQPGRVLMHDTTSTPALVDIAAMRNALDEAGVDPSVLNPGLPVDVSIDHSLAVEVYAQRDAVTLNLQHEIRRNGERYRFLRWASRVLSGVRIHPPGTGIMHTINLEQLATVVTTEERGGRLWAVPDMMIGTDSHTPMINGIGVLGWGVGGLEAQTVMFGMPTMLRIPDVIGVRLTGRLPPAAQSTDLALTVTLRLRQIGVSGEFVEFYGPGVATLSAGDRSVVANMAPEYGATTGFFAVDQRTLDYLRNTGRREDAIALVEAYTRRTGLWFDPEAEPRYTRTIEIDLQTIGMHVAGPRRPQDLLDYSETPQALAA---------------VGFVPPAPSADMPRHPVAIAAITSCTNTSDPRLLIAAGLLARKARAFGLKAPPWVKTSLAPGSPAAASYLERAGLRDDLSAVGFDIVGYGCTTCIGNPGPLTEAIRQAQAAGHSKAVAVLSGNRNFPGRVHPDLELSFIMSPPLVVAFALAGDAERNLRLDPVQTTPDGRQVFLKDLWPTREEIDAHLALAGDPSDYRRDFEIASRHPLWHALKAPDTPLFPWDARSTTLRRPPF---AAVTEGSLLGRYSAYPLLVLGDDITTDHISPASAIPPDSLVADFLVERGDNRQDLNVFASRRGNWEVMVRAAFHNKTLVNLLKPEVPLAHTLHVPSGEVQPIWEVAQRYREDGDPVVLVAGERYGTGSSRDWAAKGQRLLGIRAVLAASFERIHRSNLIGMGILPLRLPPGVNPHTLQLQPGDQLEIDaDPQHLAPRCSVAVRIRRLNGSTQALLATAAVETQLEVQLLRDGGVIPSIL-----
>UniRef50_C5AK30(6-869:884) Aconitate hydratase n=2 Tax=Burkholderia RepID=C5AK30_BURGB   E=0 s/c=0.96 id=44% cov=96%
----------DTFPVeAGEPLRFVSLQRVQRQHPRVARFPATVRVLLEAALRRLVSDASHAEAVASLLAWRPGMR--AEIPVWVSRVLLQDASGVPLLGDFAAMRTAAARAGVAAEAIRPSLPIDLVIDHSVVAAAYGDAAAQALNLEQEYRLNDERFSFVKWAAQAFDRLRVVPPGNGIVHQINLEYFAGVIAR----ADGFVFPDSVVGTDSHTTMINGLGVLGWGVGGLEAEIALLGEPLYQGAPEVVAVRLDGRLAAGVRATDAALHLTHALREFGVVGKFIEFVGPGARALAVEDRATIANMAPEYGSTTGYFGVDEATLAYLRRTGRAAEWVEQVRRYYTIQDLFGIPDEtQHDYSSVFAVDLSRVGVTVAGPSRPQQKLSLAALPPSLGGARPAAGATGGGP---------------QHGAVVLAAITSCTNTANPSAMLAAGLLARNAVARGLKPAPYVKTVLAPGSRALTRYLERAGLLAPLQQLGFFVAAYGCASCVGNTGALAPGVEQAVRDGELTVAAVLSGNRNFEGRIHPAIRANYLASPELVVAFALAGSVLRDLDTEPLGQDATGRRVYLAELRAGADEVAALAEAlVDRQAYLGLYDasQPEGADERWRGVRAQSGPVFRWDERSSYFVEPPFF-HAPARETALGAIDAARVLGVFGDAVTTDHISPVGEIAVQGVAGAYLQASGVAPADFNTYGARRCNHHVMMRGTFSNPRLVNAITG---GSTARSARSGAPGSFYDVALENIKDGVPSVVIAGKAYGSGSARDWAARGTALLGVAAVVARSFERIHRSNLVLLGVLPVELDEGVALDGIAWRGTERVAIEfDARADTPRPRALVVVSRDAVVLARAPATLRVDTAAEWRYLRGGGVLRTVFERQL-
>UniRef50_P75764(40-753:753) Uncharacterized protein ybhJ n=134 Tax=Bacteria RepID=YBHJ_ECOLI   E=1e-121 s/c=0.61 id=22% cov=67%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGSDSHTR-YGALGTMAVGEGGGELVKQLLNDTWDIDYPGVVAVHLTGKPAPYVGPQDVALAIIGAVFKNGyVKNKVMEFVGPGVSALSTDFRNSVDVMTTETTCLSSVWQTDEEVHNWLALHGRGQDYCQL------------NPQPMAYYDGCISVDLSAIKPMIALPFHPSNVYEIDTLNQNLTDILREIEIESERVAHGKAKLSLLDKVENGRLKVQQGIIAGCSGGNYENVIAAANALRGQSCG-----NDTFSLAVYPSSQPVFMDLAKKGVVADLIGAGAIIRTAFCGPCFGAG---DTPINNGL--------SIRHTTRNFPNREGSKPANGQMSAVALMDARSIAATAANG------GYLTSASEL---DCW---DNVPEYAFDVTP-YKNRVYQGFVKGATQQPLIYGPN------------IKDWP-------ELGALTDNIVLKVCSKILDEVtTTDELIPSGETSSYRSNPIGLAEFTLSRRDPG-YVSR----------SKATAELENQRLAGNVSELTEVFARIKQIAGQEHIDPLQTE-IGSMVYAVKP-GDGSAREQAASCQRVIGGLANIAEEYAtKRYRSNVINWGMLPLQMAEVPTFEV-----GDYIYIPGIKAalDNPGTTFKGYVIHEDAPVTEITLYMESLTAEEREIIKAGSLINF-------
>UniRef50_O27668(8-418:428) 3-isopropylmalate dehydratase large subunit 2 n=29 Tax=cellular organisms RepID=LEUC2_METTH  E=1e-116 s/c=1.03 id=26% cov=41%
-------------------------------------------------------------------------------------------------------RD-IASRGGPARVWDPERIV-MVFDHNVPANTIG--AAEFQRVTREFAREQGIVNIFQNAA-------------GICHQVLPER-------------GFVRPGMViVGADSHTCTYGAFGAFATGMGATDMAMVFATGKTWFMVPEAMRIEVTGEPEGHVYAKDVILHIIGEIGVDGATYRSVEFTGDTIESMDVSGRMTICNMAVEMGAKNGIMEPNRQTLDYVRArTGREFR--------------VYSSDEDSQYLEDHHFDVSDLEPQVACPDDVDNVYPVHRVEGTH---------------------------------IDEAFLGSCTNGRYEDLKIAAEVIGD------RRVHEDVRFIVSPASREIYLKALEDGIIETFIRAGAIVCNPGCGPCLGAHMGVLAPGE----------VSIATTNRNFRGRMGDPASSVYLANPAVVAESAIEG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A5UUP5(13-469:474) 3-isopropylmalate dehydratase large subunit n=60 Tax=Bacteria RepID=LEUC_ROSS1  E=1e-107 s/c=0.86 id=26% cov=38%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIVCGDSHTSTHGAFGALAFGIGTSEVAHVLATQCLIQTRPKTMEVRVDGRLAPGVTAKDIILAIIARYGVGAGTGHVFEYTGETIRALSMEERMTICNMSIEGGARAGMIAPDDTTFEYIA--GRPFAPKGKAWDEAVAYWRTLPTDEGAVYDRIITLDASQLTPMITYGTNPGMGMPIDGRIPTPEELPDP--AARQALDKALRYMDLRPGQPLLGHKIDVVFLGSCTNSRISDLRMAARLL------KGRKIADGVRMMVVPGSQQVKKQAEAEGLHEIFRAAGAEWREAGCSACLGMNDDKVPPGRY----------AVSTSNRNFEGRQGPGART-FLASPLTAVASAIEGAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1B740(6-410:417) Homoaconitate hydratase family protein n=2 Tax=Synergistaceae RepID=D1B740_THEAS  E=1e-106 s/c=0.96 id=30% cov=33%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVGADSHTCTMGALGALGTGMGSTDLAAIWALGHTWMKVPPTVRVHLEGSFKPFVGGKDAMLHIIGTLGVDGARYRALEFHGDGVRSLSMDGRMTMANMGIECGAKAALFVPDEATLAYVAPRArRSFEPVY--------------PDPGAAYERELTVRLDSLPPLVACPNLPSNVRPARE---------------------------------LRDVEIHQVFIGSCTNGRIEDLRQAAKVL------KGRRLHPSVRGVLIPASRRDMAAAMQEGLMEVFMEAGFSICTPSCGPCLGGHLGILAEGE----------VCVSTGNRNFTGRMGHPRSQVYLASPAVAAASGVMGRI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2G958(29-471:478) 3-isopropylmalate dehydratase large subunit n=67 Tax=cellular organisms RepID=LEUC_NOVAD  E=1e-104 s/c=0.86 id=28% cov=38%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIVCGDSHTACHGGLGALAFGIGTSEVEHVLATQTLLLKQSKTMEVRVEGELTPGVTAKDVVLHITGVLGAAGGTGSVIEYTGSVIRDLSIEGRLTISNMAIEHGARAGLCAPDEKTFAYLK--GRPYAPRGEDWDKAVAWWKSLATDPGATYDKVVVIDAKDIAPSVTWGTSPEDVLPISGL--VPAPESFADPSKQEAARASLEYMGLVPGQRMEDVEVQNIFIGSCTNSRIEDMRAAAAIL------KGRKKADNVKwAIVVPGSGLVKKQAEEEGLDRVFIEAGFEWREPGCSACLGMNPDKVPAGER----------CASTSNRNFVGRQGPGART-HLVSPAMAAAAAVTGRL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q9RTI6(2-431:431) 3-isopropylmalate dehydratase large subunit 2 n=3 Tax=Deinococcus RepID=LEUC2_DEIRA  E=1e-103 s/c=0.88 id=29% cov=35%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLVSGDSHTCNAGALGAFATGVGSTDLAGAIYAGKVWFKVPETMLIRVTGKTNPGVTPKDIVLEVIKQIGADGANYMVMEWVGDYIDQLDMEGRFTLTNMAIEAGGKTGIVAVDDTTRAYMQQRGVSPE-----------QYTEYQSDPDAKYKVVVEIDAAQVEPTVAYPHIPSN----------------------------------GRVAGSDRIRVTHAYVGSCTNGRITDLRDVARIL------KGRKVAQDVQMIVVPATQAIWKQAAQEGLLEIFVDAGASVSYPSCGACLGMHSGVLGPDD----------ICISSSNRNFVGRMGDPSAQIYLASPATVAASAVEGFIA-----DPRRYDAEGNDLNAAD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C9KK15(5-415:423) Homoaconitate hydratase n=2 Tax=Bacteria RepID=C9KK15_9FIRM   E=1e-102 s/c=0.91 id=31% cov=32%
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSHTTTHGAFGAFGTGVGATDLAVILATGRLWFKVPEVIRINLTGKIPAGVYAKDIVLSIIGKLKADYAVYKAVEFAGPALQQLSISERMALCNMTTEMGAKTSYIQPDAITLQFLKERGRQDFTV-------------YETDADYVYAADLTFDVSEVEPQLAAPFSVDNVQALSAYAG---------------------------------MHVDQAYLGSCTGGRTEDFAVAAKILA------GQHIPAGTRMVMVPASKAVLAECLAKGYIQTLLAAGATLTASGCAACLGIHQGLLAADE----------VCLSSTNRNFPGRMGSVKGRIYLGSPASVAAAA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1L5I9(1-408:413) 3-isopropylmalate dehydratase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I9_KORCO  E=3e-94 s/c=0.86 id=31% cov=35%
----------------------------------------------------------------------------------------------------------------------------------------------------------------RWGVRIFD------VGEGICHQVIPER-------------GLVKPwDLVIGADSHTVTLGALGAFATGVGSTDAAIAMLTGKIWLKVPESIAVKVDGTLKNHVTAKDVILEVIGRLGSDGANYKAVEFLGSAVEAMSLDSKMVLANMSVEMGAKVAMIPTDGRTSEWLK------------ERVGHFEGIW--PDEEANYSAFYEFPAEEIKPNVSLPNSVD---------------------------------RVAPVEEVEGEEVDLVFIGSCSGGRFEDFLLASRIM------RGRKLKEGVRCITVPASKEVQMKLIDSGLMRSLLEFGCTVGPPTCGPCIGAHMGLAGPGE----------TVVSTSTRNFPGRMGSPDSRVYLASP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9B805(2-409:421) 3-isopropylmalate dehydratase large subunit n=14 Tax=Bacteria RepID=LEUC_HERA2  E=4e-91 s/c=0.83 id=28% cov=32%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVGSDSHSTGYGAAAAFGSGMGTTDIALALATGQTWFRVPETVRVNAVGNFQPGVSVKDFGLWAARTLRADGATYQSVEWHG--VDFLSWRERMTLATLSIEVGAKAGIVAP----------TGLGAEH---------PVPEWLRVEADASYSRVVECDLSTLEPQVSVPHYVDNVVDLADV---------------------------------GRVAVDVVYLGTCTNGHYEDMAAAASIL------KGRRLAPNVRMIVVPASSESLHRAASDGTLATLLAAGATIGTPGCGACIGRHMGVLAPDE----------VCVFTGNRNFRGRMGSPGANIYLASPEVAAATAVTG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q5NTF8(7-365:369) Aconitase (Fragment) n=1 Tax=uncultured bacterium RepID=Q5NTF8_9BACT  E=7e-71 s/c=0.75 id=24% cov=40%
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERDGLLADLEAIGATVLANACGPCIGQW-------ERSKDITSKPNTIVNSFNRNFPRRNdGSANTLSFVTSPDTVIALALAGRLDFDPIIDTI-TAPDGTVVRLE---PPRGEI------LPARGYDSGKNTFIAPPADGSAIQVVVSP------SSDRLQLLHAFPAWDG-----KDYLELPVLMKARGKCTTDHIS---------AAGKWLTYRGHLENISGNLFA----------------GVVNAFTGMAGGGL--DILDGTARPFPEIAKRYSIAGVRWCAVGDQNYGEGSSREHAAMEPRYRGGVVILARSFARIHETNLKKQG-LCATYVCRTRIRTISSVNATPSACSGYRRCQ-KKPVRCVINKPYGTTIEFEALHTF-SAEQVEWFKAGSALNVVRQKL--
>UniRef50_A6XPX3(1-311:319) Putative uncharacterized protein (Fragment) n=1 Tax=Botryotinia fuckeliana B05.10 RepID=A6XPX3_BOTFB  E=1e-65 s/c=0.82 id=26% cov=32%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIGATTSLFPFNDRMYDYLAATKRTE-----IGDFARTYAKELKEDEGAQYDELIEINLSELEPHINGPFTPDLATPISKFSEAVKANNWPEELK-------------------------VGLIGSCTNSSYEDMSRAASI-AEDAMAHGVKAKAL--FTVTPGSEQIRATIERDGQLKTFEDFGGMVLANACGPCIGQWDRRDVP-------KGTANSIISSYNRNFTGRNDANPAtHSFVASPDLVVAMTIAGSLHFNPLTDTL---------------------------------KDTYQAPPAERA---------SVNVAVSPTSDRLQLLEPFNAWDG-----KDALDMPILIKAKGKTTTDHISMAG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
