Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	Q	Y	L	E	L	M	Q	K	V	L	D	E	G	T	Q	K	N	D	R	T	G	T	G	T	L	S	I	F	G	H	Q	M	R	F	N	L	Q	D	G	F	P	L	V	T	T	K	R	C	H	L	R	S	I	I	H	E	L	L
Secondary structure
SS confidence
Disorder		?																	?			?																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		W	F	L	Q	G	D	T	N	I	A	Y	L	H	E	N	N	V	T	I	W	D	E	W	A	D	E	N	G	D	L	G	P	V	Y	G	K	Q	W	R	A	W	P	T	P	D	G	R	H	I	D	Q	I	T	T	V	L	N	Q	L	K
Secondary structure
SS confidence
Disorder																												?																?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		N	D	P	D	S	R	R	I	I	V	S	A	W	N	V	G	E	L	D	K	M	A	L	A	P	C	H	A	F	F	Q	F	Y	V	A	D	G	K	L	S	C	Q	L	Y	Q	R	S	C	D	V	F	L	G	L	P	F	N	I	A	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Y	A	L	L	V	H	M	M	A	Q	Q	C	D	L	E	V	G	D	F	V	W	T	G	G	D	T	H	L	Y	S	N	H	M	D	Q	T	H	L	Q	L	S	R	E	P	R	P	L	P	K	L	I	I	K	R	K	P	E	S	I	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.
Sequence		D	Y	R	F	E	D	F	E	I	E	G	Y	D	P	H	P	G	I	K	A	P	V	A	I
Secondary structure
SS confidence
Disorder																				?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2oip chain E Region: 2 - 264 Aligned: 263 Modelled: 263 Confidence: 100.0% Identity: 51% PDB header:transferase, oxidoreductase Chain: E: PDB Molecule:chain a, crystal structure of dhfr; PDBTitle: crystal structure of the s290g active site mutant of ts-2 dhfr from cryptosporidium hominis Phyre2 PDB 1qzf chain A domain 2 Region: 2 - 264 Aligned: 263 Modelled: 263 Confidence: 100.0% Identity: 51% Fold: Thymidylate synthase/dCMP hydroxymethylase Superfamily: Thymidylate synthase/dCMP hydroxymethylase Family: Thymidylate synthase/dCMP hydroxymethylase Phyre2 PDB 1j3k chain C Region: 2 - 263 Aligned: 262 Modelled: 262 Confidence: 100.0% Identity: 48% Fold: Thymidylate synthase/dCMP hydroxymethylase Superfamily: Thymidylate synthase/dCMP hydroxymethylase Family: Thymidylate synthase/dCMP hydroxymethylase Phyre2 PDB 3jsu chain A Region: 2 - 262 Aligned: 261 Modelled: 261 Confidence: 100.0% Identity: 48% PDB header:oxidoreductase, transferase Chain: A: PDB Molecule:dihydrofolate reductase-thymidylate synthase; PDBTitle: quadruple mutant(n51i+c59r+s108n+i164l) plasmodium falciparum2 dihydrofolate reductase-thymidylate synthase(pfdhfr-ts) complexed3 with qn254, nadph, and dump Phyre2 PDB 1tsw chain A Region: 2 - 264 Aligned: 263 Modelled: 263 Confidence: 100.0% Identity: 60% Fold: Thymidylate synthase/dCMP hydroxymethylase Superfamily: Thymidylate synthase/dCMP hydroxymethylase Family: Thymidylate synthase/dCMP hydroxymethylase Phyre2 PDB 3k2h chain A Region: 2 - 263 Aligned: 262 Modelled: 262 Confidence: 100.0% Identity: 49% PDB header:transferase Chain: A: PDB Molecule:dihydrofolate reductase/thymidylate synthase; PDBTitle: co-crystal structure of dihydrofolate reductase/thymidylate synthase2 from babesia bovis with dump, pemetrexed and nadp Phyre2 PDB 2g8o chain A domain 1 Region: 2 - 264 Aligned: 263 Modelled: 263 Confidence: 100.0% Identity: 100% Fold: Thymidylate synthase/dCMP hydroxymethylase Superfamily: Thymidylate synthase/dCMP hydroxymethylase Family: Thymidylate synthase/dCMP hydroxymethylase Phyre2 PDB 3qj7 chain D Region: 1 - 264 Aligned: 260 Modelled: 264 Confidence: 100.0% Identity: 66% PDB header:transferase Chain: D: PDB Molecule:thymidylate synthase; PDBTitle: crystal structure of the mycobacterium tuberculosis thymidylate2 synthase (thya) bound to dump Phyre2 PDB 3clb chain A Region: 2 - 259 Aligned: 258 Modelled: 258 Confidence: 100.0% Identity: 51% PDB header:oxidoreductase, transferase Chain: A: PDB Molecule:dhfr-ts; PDBTitle: structure of bifunctional tcdhfr-ts in complex with tmq Phyre2 PDB 1hvy chain A Region: 2 - 264 Aligned: 262 Modelled: 263 Confidence: 100.0% Identity: 56% Fold: Thymidylate synthase/dCMP hydroxymethylase Superfamily: Thymidylate synthase/dCMP hydroxymethylase Family: Thymidylate synthase/dCMP hydroxymethylase Phyre2 PDB 1sej chain A domain 2 Region: 2 - 264 Aligned: 263 Modelled: 263 Confidence: 100.0% Identity: 51% Fold: Thymidylate synthase/dCMP hydroxymethylase Superfamily: Thymidylate synthase/dCMP hydroxymethylase Family: Thymidylate synthase/dCMP hydroxymethylase Phyre2 PDB 2aaz chain G Region: 2 - 263 Aligned: 262 Modelled: 262 Confidence: 100.0% Identity: 49% PDB header:transferase Chain: G: PDB Molecule:thymidylate synthase; PDBTitle: cryptococcus neoformans thymidylate synthase complexed with2 substrate and an antifolate Phyre2 PDB 1f28 chain A Region: 2 - 264 Aligned: 263 Modelled: 263 Confidence: 100.0% Identity: 49% Fold: Thymidylate synthase/dCMP hydroxymethylase Superfamily: Thymidylate synthase/dCMP hydroxymethylase Family: Thymidylate synthase/dCMP hydroxymethylase Phyre2 PDB 2tsr chain A Region: 2 - 258 Aligned: 257 Modelled: 257 Confidence: 100.0% Identity: 55% Fold: Thymidylate synthase/dCMP hydroxymethylase Superfamily: Thymidylate synthase/dCMP hydroxymethylase Family: Thymidylate synthase/dCMP hydroxymethylase Phyre2 PDB 1bkp chain A Region: 2 - 264 Aligned: 262 Modelled: 263 Confidence: 100.0% Identity: 37% Fold: Thymidylate synthase/dCMP hydroxymethylase Superfamily: Thymidylate synthase/dCMP hydroxymethylase Family: Thymidylate synthase/dCMP hydroxymethylase Phyre2 PDB 1tis chain A Region: 1 - 264 Aligned: 259 Modelled: 264 Confidence: 100.0% Identity: 50% Fold: Thymidylate synthase/dCMP hydroxymethylase Superfamily: Thymidylate synthase/dCMP hydroxymethylase Family: Thymidylate synthase/dCMP hydroxymethylase Phyre2 PDB 1hw3 chain A Region: 2 - 261 Aligned: 246 Modelled: 260 Confidence: 100.0% Identity: 56% PDB header:transferase Chain: A: PDB Molecule:thymidylate synthase; PDBTitle: structure of human thymidylate synthase suggests advantages of2 chemotherapy with noncompetitive inhibitors Phyre2 PDB 1hw4 chain A Region: 2 - 261 Aligned: 247 Modelled: 260 Confidence: 100.0% Identity: 56% PDB header:transferase Chain: A: PDB Molecule:thymidylate synthase; PDBTitle: structure of thymidylate synthase suggests advantages of chemotherapy2 with noncompetitive inhibitors Phyre2 PDB 3ix6 chain B Region: 1 - 251 Aligned: 243 Modelled: 251 Confidence: 100.0% Identity: 66% PDB header:transferase Chain: B: PDB Molecule:thymidylate synthase; PDBTitle: crystal structure of thymidylate synthase thya from brucella2 melitensis Phyre2 PDB 3kgb chain A Region: 2 - 255 Aligned: 240 Modelled: 254 Confidence: 100.0% Identity: 50% PDB header:transferase Chain: A: PDB Molecule:thymidylate synthase 1/2; PDBTitle: crystal structure of thymidylate synthase 1/2 from encephalitozoon2 cuniculi at 2.2 a resolution Phyre2 1 c2oipE_ 2 d1qzfa2 3 d1j3kc_ 4 c3jsuA_ 5 d1tswa_ 6 c3k2hA_ 7 d2g8oa1 8 c3qj7D_ 9 c3clbA_ 10 d1hvya_ 11 d1seja2 12 c2aazG_ 13 d1f28a_ 14 d2tsra_ 15 d1bkpa_ 16 d1tisa_ 17 c1hw3A_ 18 c1hw4A_ 19 c3ix6B_ 20 c3kgbA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2oipE_ 100.0 51 PDB header:transferase, oxidoreductase Chain: E: PDB Molecule:chain a, crystal structure of dhfr; PDBTitle: crystal structure of the s290g active site mutant of ts-2 dhfr from cryptosporidium hominis 2 d1qzfa2 100.0 51 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 3 d1j3kc_ 100.0 48 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 4 c3jsuA_ 100.0 48 PDB header:oxidoreductase, transferase Chain: A: PDB Molecule:dihydrofolate reductase-thymidylate synthase; PDBTitle: quadruple mutant(n51i+c59r+s108n+i164l) plasmodium falciparum2 dihydrofolate reductase-thymidylate synthase(pfdhfr-ts) complexed3 with qn254, nadph, and dump 5 d1tswa_ 100.0 60 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 6 c3k2hA_ 100.0 49 PDB header:transferase Chain: A: PDB Molecule:dihydrofolate reductase/thymidylate synthase; PDBTitle: co-crystal structure of dihydrofolate reductase/thymidylate synthase2 from babesia bovis with dump, pemetrexed and nadp 7 d2g8oa1 100.0 100 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 8 c3qj7D_ 100.0 66 PDB header:transferase Chain: D: PDB Molecule:thymidylate synthase; PDBTitle: crystal structure of the mycobacterium tuberculosis thymidylate2 synthase (thya) bound to dump 9 c3clbA_ 100.0 51 PDB header:oxidoreductase, transferase Chain: A: PDB Molecule:dhfr-ts; PDBTitle: structure of bifunctional tcdhfr-ts in complex with tmq 10 d1hvya_ 100.0 56 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 11 d1seja2 100.0 51 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 12 c2aazG_ 100.0 49 PDB header:transferase Chain: G: PDB Molecule:thymidylate synthase; PDBTitle: cryptococcus neoformans thymidylate synthase complexed with2 substrate and an antifolate 13 d1f28a_ 100.0 49 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 14 d2tsra_ 100.0 55 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 15 d1bkpa_ 100.0 37 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 16 d1tisa_ 100.0 50 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 17 c1hw3A_ 100.0 56 PDB header:transferase Chain: A: PDB Molecule:thymidylate synthase; PDBTitle: structure of human thymidylate synthase suggests advantages of2 chemotherapy with noncompetitive inhibitors 18 c1hw4A_ 100.0 56 PDB header:transferase Chain: A: PDB Molecule:thymidylate synthase; PDBTitle: structure of thymidylate synthase suggests advantages of chemotherapy2 with noncompetitive inhibitors 19 c3ix6B_ 100.0 66 PDB header:transferase Chain: B: PDB Molecule:thymidylate synthase; PDBTitle: crystal structure of thymidylate synthase thya from brucella2 melitensis 20 c3kgbA_ 100.0 50 PDB header:transferase Chain: A: PDB Molecule:thymidylate synthase 1/2; PDBTitle: crystal structure of thymidylate synthase 1/2 from encephalitozoon2 cuniculi at 2.2 a resolution 21 d1b5ea_ not modelled 100.0 24 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 22 c2vsvB_ not modelled 42.0 9 PDB header:protein-binding Chain: B: PDB Molecule:rhophilin-2; PDBTitle: crystal structure of the pdz domain of human rhophilin-2 23 c2q3gA_ not modelled 35.1 22 PDB header:structural genomics Chain: A: PDB Molecule:pdz and lim domain protein 7; PDBTitle: structure of the pdz domain of human pdlim7 bound to a c-2 terminal extension from human beta-tropomyosin 24 c3o46A_ not modelled 28.1 13 PDB header:protein binding Chain: A: PDB Molecule:maguk p55 subfamily member 7; PDBTitle: crystal structure of the pdz domain of mpp7 25 d1r6ja_ not modelled 28.0 13 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 26 c1r6jA_ not modelled 28.0 13 PDB header:membrane protein Chain: A: PDB Molecule:syntenin 1; PDBTitle: ultrahigh resolution crystal structure of syntenin pdz2 27 c1nteA_ not modelled 28.0 13 PDB header:signaling protein Chain: A: PDB Molecule:syntenin 1; PDBTitle: crystal structure analysis of the second pdz domain of2 syntenin 28 c3diwB_ not modelled 27.5 19 PDB header:signaling protein/cell adhesion Chain: B: PDB Molecule:tax1-binding protein 3; PDBTitle: c-terminal beta-catenin bound tip-1 structure 29 c2jikB_ not modelled 27.2 16 PDB header:membrane protein Chain: B: PDB Molecule:synaptojanin-2 binding protein; PDBTitle: crystal structure of pdz domain of synaptojanin-2 binding2 protein 30 d1ueza_ not modelled 26.2 16 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 31 c2eeiA_ not modelled 25.9 6 PDB header:metal binding protein Chain: A: PDB Molecule:pdz domain-containing protein 1; PDBTitle: solution structure of second pdz domain of pdz domain2 containing protein 1 32 d1w9ea1 not modelled 25.8 20 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 33 d1wi2a_ not modelled 24.4 18 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 34 c3khfA_ not modelled 24.4 14 PDB header:transferase Chain: A: PDB Molecule:microtubule-associated serine/threonine-protein PDBTitle: the crystal structure of the pdz domain of human microtubule2 associated serine/threonine kinase 3 (mast3) 35 d1tp5a1 not modelled 23.3 19 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 36 d1fc6a3 not modelled 23.1 14 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:Tail specific protease PDZ domain 37 d1vaea_ not modelled 22.8 9 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 38 c2d8iA_ not modelled 21.4 16 PDB header:immune system, signaling protein Chain: A: PDB Molecule:t-cell lymphoma invasion and metastasis 1 PDBTitle: solution structure of the pdz domain of t-cell lymphoma2 invasion and metastasis 1 varian 39 c2dkrA_ not modelled 20.1 18 PDB header:protein transport Chain: A: PDB Molecule:lin-7 homolog b; PDBTitle: solution structure of the pdz domain from human lin-72 homolog b 40 c2jxoA_ not modelled 19.3 11 PDB header:protein binding Chain: A: PDB Molecule:ezrin-radixin-moesin-binding phosphoprotein 50; PDBTitle: structure of the second pdz domain of nherf-1 41 c2kv8A_ not modelled 18.4 13 PDB header:signaling protein Chain: A: PDB Molecule:regulator of g-protein signaling 12; PDBTitle: solution structure ofrgs12 pdz domain 42 c2fneB_ not modelled 17.0 15 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:multiple pdz domain protein; PDBTitle: the crystal structure of the 13th pdz domain of mpdz 43 c2d90A_ not modelled 16.8 17 PDB header:protein binding Chain: A: PDB Molecule:pdz domain containing protein 1; PDBTitle: solution structure of the third pdz domain of pdz domain2 containing protein 1 44 d1kwaa_ not modelled 15.0 16 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 45 d1y7na1 not modelled 14.7 14 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 46 c3shuB_ not modelled 14.4 22 PDB header:cell adhesion Chain: B: PDB Molecule:tight junction protein zo-1; PDBTitle: crystal structure of zo-1 pdz3 47 c2ejyA_ not modelled 14.4 19 PDB header:membrane protein Chain: A: PDB Molecule:55 kda erythrocyte membrane protein; PDBTitle: solution structure of the p55 pdz t85c domain complexed2 with the glycophorin c f127c peptide 48 d1wi4a1 not modelled 13.9 13 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 49 c2e7kA_ not modelled 13.9 22 PDB header:membrane protein Chain: A: PDB Molecule:maguk p55 subfamily member 2; PDBTitle: solution structure of the pdz domain from human maguk p552 subfamily member 2 50 d1p1da2 not modelled 13.3 27 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 51 d1t2ma1 not modelled 13.3 15 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 52 d1nowa1 not modelled 13.3 23 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain 53 c1w9qB_ not modelled 13.1 12 PDB header:cell adhesion Chain: B: PDB Molecule:syntenin 1; PDBTitle: crystal structure of the pdz tandem of human syntenin in2 complex with tnefaf peptide 54 d1ihja_ not modelled 12.5 16 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 55 c2kjdA_ not modelled 11.8 11 PDB header:signaling protein Chain: A: PDB Molecule:sodium/hydrogen exchange regulatory cofactor nhe- PDBTitle: solution structure of extended pdz2 domain from nherf1 (150-2 270) 56 c3qglD_ not modelled 11.8 11 PDB header:protein binding Chain: D: PDB Molecule:sorting nexin-27; PDBTitle: crystal structure of pdz domain of sorting nexin 27 (snx27) in complex2 with the eseskv peptide corresponding to the c-terminal tail of girk3 57 d1uepa_ not modelled 11.6 18 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 58 c2v90E_ not modelled 11.5 8 PDB header:protein-binding Chain: E: PDB Molecule:pdz domain-containing protein 3; PDBTitle: crystal structure of the 3rd pdz domain of intestine- and2 kidney-enriched pdz domain ikepp (pdzd3) 59 c2d92A_ not modelled 11.2 24 PDB header:protein binding Chain: A: PDB Molecule:inad-like protein; PDBTitle: solution structure of the fifth pdz domain of inad-like2 protein 60 c2iwnA_ not modelled 11.1 18 PDB header:signaling protein Chain: A: PDB Molecule:multiple pdz domain protein; PDBTitle: 3rd pdz domain of multiple pdz domain protein mpdz (casp2 target) 61 c2z17A_ not modelled 11.0 14 PDB header:protein binding Chain: A: PDB Molecule:pleckstrin homology sec7 and coiled-coil domains- PDBTitle: crystal sturcture of pdz domain from human pleckstrin2 homology, sec7 62 c3l4fD_ not modelled 10.8 17 PDB header:signaling protein/protein binding Chain: D: PDB Molecule:sh3 and multiple ankyrin repeat domains protein PDBTitle: crystal structure of betapix coiled-coil domain and shank2 pdz complex 63 c1u3bA_ not modelled 10.4 14 PDB header:protein transport Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding, PDBTitle: auto-inhibition mechanism of x11s/mints family scaffold2 proteins revealed by the closed conformation of the tandem3 pdz domains 64 c2eehA_ not modelled 10.2 27 PDB header:metal binding protein Chain: A: PDB Molecule:pdz domain-containing protein 7; PDBTitle: solution structure of first pdz domain of pdz domain2 containing protein 7 65 d1uita_ not modelled 10.2 27 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 66 c2gzvA_ not modelled 10.1 7 PDB header:signaling protein Chain: A: PDB Molecule:prkca-binding protein; PDBTitle: the cystal structure of the pdz domain of human pick1 (casp target) 67 d2byga1 not modelled 10.0 24 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 68 c2jilA_ not modelled 9.9 14 PDB header:membrane protein Chain: A: PDB Molecule:glutamate receptor interacting protein-1; PDBTitle: crystal structure of 2nd pdz domain of glutamate receptor2 interacting protein-1 (grip1) 69 c2egkC_ not modelled 9.9 13 PDB header:protein binding Chain: C: PDB Molecule:general receptor for phosphoinositides 1- PDBTitle: crystal structure of tamalin pdz-intrinsic ligand fusion2 protein 70 d1jaka1 not modelled 9.8 19 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain 71 d1wh1a_ not modelled 9.7 18 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 72 d2fcfa1 not modelled 9.7 18 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 73 d2o7ta1 not modelled 9.6 22 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Tetracyclin repressor-like, N-terminal domain 74 c3qikA_ not modelled 9.5 14 PDB header:hydrolase regulator Chain: A: PDB Molecule:phosphatidylinositol 3,4,5-trisphosphate-dependent rac PDBTitle: crystal structure of the first pdz domain of prex1 75 d1jt6a1 not modelled 9.5 8 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Tetracyclin repressor-like, N-terminal domain 76 c3m4rA_ not modelled 9.5 14 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: structure of the n-terminal class ii aldolase domain of a conserved2 protein from thermoplasma acidophilum 77 c3rcnA_ not modelled 9.4 13 PDB header:hydrolase Chain: A: PDB Molecule:beta-n-acetylhexosaminidase; PDBTitle: crystal structure of beta-n-acetylhexosaminidase from arthrobacter2 aurescens 78 d1lcya1 not modelled 9.4 19 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:HtrA-like serine proteases 79 d1be9a_ not modelled 9.3 19 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 80 d1q3oa_ not modelled 9.3 16 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 81 d1ky9b2 not modelled 9.1 22 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:HtrA-like serine proteases 82 d2f5ya1 not modelled 9.0 14 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 83 c2ka9A_ not modelled 8.9 14 PDB header:cell adhesion Chain: A: PDB Molecule:disks large homolog 4; PDBTitle: solution structure of psd-95 pdz12 complexed with cypin2 peptide 84 d1pi1a_ not modelled 8.9 31 Fold:Bromodomain-like Superfamily:Mob1/phocein Family:Mob1/phocein 85 c1m04A_ not modelled 8.8 16 PDB header:hydrolase Chain: A: PDB Molecule:beta-n-acetylhexosaminidase; PDBTitle: mutant streptomyces plicatus beta-hexosaminidase (d313n) in complex2 with product (glcnac) 86 d2gjxa1 not modelled 8.6 16 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain 87 c2yuyA_ not modelled 8.5 14 PDB header:signaling protein Chain: A: PDB Molecule:rho gtpase activating protein 21; PDBTitle: solution structure of pdz domain of rho gtpase activating2 protein 21 88 c2yubA_ not modelled 8.4 15 PDB header:transferase Chain: A: PDB Molecule:lim domain kinase 2; PDBTitle: solution structure of the pdz domain from mouse lim domain2 kinase 89 d1u3ba2 not modelled 8.3 14 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 90 c2dm8A_ not modelled 8.1 19 PDB header:protein binding Chain: A: PDB Molecule:inad-like protein; PDBTitle: solution structure of the eighth pdz domain of human inad-2 like protein 91 d1qaua_ not modelled 8.0 24 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 92 c1obyA_ not modelled 7.9 14 PDB header:cell adhesion Chain: A: PDB Molecule:syntenin 1; PDBTitle: crystal structure of the complex of pdz2 of syntenin with2 a syndecan-4 peptide. 93 c1nouA_ not modelled 7.8 23 PDB header:hydrolase Chain: A: PDB Molecule:beta-hexosaminidase beta chain; PDBTitle: native human lysosomal beta-hexosaminidase isoform b 94 c2hjnA_ not modelled 7.7 23 PDB header:cell cycle Chain: A: PDB Molecule:maintenance of ploidy protein mob1; PDBTitle: structural and functional analysis of saccharomyces2 cerevisiae mob1 95 d1iyjb4 not modelled 7.6 18 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Single strand DNA-binding domain, SSB 96 d1wj2a_ not modelled 7.4 38 Fold:WRKY DNA-binding domain Superfamily:WRKY DNA-binding domain Family:WRKY DNA-binding domain 97 c3lfhF_ not modelled 7.3 62 PDB header:transferase Chain: F: PDB Molecule:phosphotransferase system, mannose/fructose-specific PDBTitle: crystal structure of manxa from thermoanaerobacter tengcongensis 98 c3enhD_ not modelled 7.3 22 PDB header:hydrolase/unknown function Chain: D: PDB Molecule:uncharacterized protein mj0187; PDBTitle: crystal structure of cgi121/bud32/kae1 complex 99 c4a8aI_ not modelled 7.3 27 PDB header:hydrolase/hydrolase Chain: I: PDB Molecule:periplasmic ph-dependent serine endoprotease degq; PDBTitle: asymmetric cryo-em reconstruction of e. coli degq 12-mer in complex2 with lysozyme

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0