PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c3kgbA_

Fold library id	PDB Header	Molecule	Title
c3kgbA_	PDB header: transferase	Chain: A: PDB Molecule: thymidylate synthase 1/2;	PDBTitle: crystal structure of thymidylate synthase 1/2 from2 encephalitozoon cuniculi at 2.2 a resolution

Links to external resources
Added to library: Sat Aug 28 21:12:13 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence H P E H Q Y L D L V K H I L E N G A R R M T G T L S V F G A T M R F S L E D N T F P L L T T R R V F Y R G V V E E L L F F L R G E T D S K V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T
G G G B
S S S
T T
T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence L E K K G V R D L G P I Y G F Q W R H F G A R Y E T S A S S Y E G K G V D Q I A S A I A A I R A N P A S R R I V V S A W N P T D L G S M A L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T
S
S B T
T T S
T T S S B
T T
S
T T
S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence P P C H V L F Q F N V T D G K L S C A M Y Q R S G D M G L G V P F N I A S Y S L L T I L V A H L T G L Q P G E F V H F L G D A H V Y L D H V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S T T T T T T T
G G G

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . .

Sequence D S L R Q Q I Q R P P R A F P K L F V S P K G P R T E P E H F Q Y E D F E L V G Y D P H

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S
S S
S G G G
G G G S

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	H	P	E	H	Q	Y	L	D	L	V	K	H	I	L	E	N	G	A	R	R	M	T	G	T	L	S	V	F	G	A	T	M	R	F	S	L	E	D	N	T	F	P	L	L	T	T	R	R	V	F	Y	R	G	V	V	E	E	L	L	F	F	L	R	G	E	T	D	S	K	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T																																			G	G	G	B					S	S	S																T	T				T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	L	E	K	K	G	V	R	D	L	G	P	I	Y	G	F	Q	W	R	H	F	G	A	R	Y	E	T	S	A	S	S	Y	E	G	K	G	V	D	Q	I	A	S	A	I	A	A	I	R	A	N	P	A	S	R	R	I	V	V	S	A	W	N	P	T	D	L	G	S	M	A	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			T	T	T						S								S	B	T						T	T	S			T	T	S	S	B														T	T		S									T	T							S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	P	P	C	H	V	L	F	Q	F	N	V	T	D	G	K	L	S	C	A	M	Y	Q	R	S	G	D	M	G	L	G	V	P	F	N	I	A	S	Y	S	L	L	T	I	L	V	A	H	L	T	G	L	Q	P	G	E	F	V	H	F	L	G	D	A	H	V	Y	L	D	H	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			S										T	T													T	T	T																				T	T																	G	G	G
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.
Sequence	D	S	L	R	Q	Q	I	Q	R	P	P	R	A	F	P	K	L	F	V	S	P	K	G	P	R	T	E	P	E	H	F	Q	Y	E	D	F	E	L	V	G	Y	D	P	H
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							T	T	S													S	S				S	G	G	G			G	G	G					S