Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	Q	L	N	S	V	W	V	F	S	D	N	P	E	R	Y	A	E	L	F	G	G	A	Q	Q	W	G	Q	Q	V	Y	A	I	V	Q	N	T	D	Q	A	Q	A	V	M	P	Y	G	P	K	C	L	Y	V	L	A	Q	N	D	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	Q	R	T	E	N	Y	A	E	S	I	A	A	L	L	K	D	K	H	P	A	M	L	L	L	A	A	T	K	R	G	K	A	L	A	A	R	L	S	V	Q	L	N	A	A	L	V	N	D	A	T	A	V	D	I	V	D	G	H	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		C	A	E	H	R	M	Y	G	G	L	A	F	A	Q	E	K	I	N	S	P	L	A	I	I	T	L	A	P	G	V	Q	E	P	C	T	S	D	T	S	H	Q	C	P	T	E	T	V	P	Y	V	A	P	R	H	E	I	L	C	R	E
Secondary structure
SS confidence
Disorder																															?	?	?	?	?	?	?	?	?	?	?	?												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	R	A	K	A	A	S	S	V	D	L	S	K	A	K	R	V	V	G	V	G	R	G	L	A	A	Q	D	D	L	K	M	V	H	E	L	A	A	V	L	N	A	E	V	G	C	S	R	P	I	A	E	G	E	N	W	M	E	R	E
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?																?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	Y	I	G	V	S	G	V	L	L	K	S	D	L	Y	L	T	L	G	I	S	G	Q	I	Q	H	M	V	G	G	N	G	A	K	V	I	V	A	I	N	K	D	K	N	A	P	I	F	N	Y	A	D	Y	G	L	V	G	D	I	Y
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.
Sequence		K	V	V	P	A	L	I	S	Q	L	S	R
Secondary structure
SS confidence
Disorder												?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1efp chain C Region: 6 - 310 Aligned: 297 Modelled: 305 Confidence: 100.0% Identity: 29% PDB header:electron transport Chain: C: PDB Molecule:protein (electron transfer flavoprotein); PDBTitle: electron transfer flavoprotein (etf) from paracoccus2 denitrificans Phyre2 PDB 1efv chain A domain 2 Region: 187 - 311 Aligned: 124 Modelled: 125 Confidence: 100.0% Identity: 43% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: C-terminal domain of the electron transfer flavoprotein alpha subunit Phyre2 PDB 1efp chain A domain 2 Region: 186 - 310 Aligned: 124 Modelled: 125 Confidence: 100.0% Identity: 45% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: C-terminal domain of the electron transfer flavoprotein alpha subunit Phyre2 PDB 3cls chain D domain 2 Region: 188 - 310 Aligned: 122 Modelled: 123 Confidence: 100.0% Identity: 37% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: C-terminal domain of the electron transfer flavoprotein alpha subunit Phyre2 PDB 3cls chain D domain 1 Region: 5 - 177 Aligned: 173 Modelled: 173 Confidence: 100.0% Identity: 18% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 1o94 chain D Region: 5 - 177 Aligned: 173 Modelled: 173 Confidence: 100.0% Identity: 18% PDB header:electron transport Chain: D: PDB Molecule:electron transfer flavoprotein alpha-subunit; PDBTitle: ternary complex between trimethylamine dehydrogenase and2 electron transferring flavoprotein Phyre2 PDB 3ih5 chain A Region: 5 - 169 Aligned: 165 Modelled: 165 Confidence: 100.0% Identity: 22% PDB header:electron transport Chain: A: PDB Molecule:electron transfer flavoprotein alpha-subunit; PDBTitle: crystal structure of electron transfer flavoprotein alpha-2 subunit from bacteroides thetaiotaomicron Phyre2 PDB 1efv chain A domain 1 Region: 5 - 186 Aligned: 178 Modelled: 182 Confidence: 100.0% Identity: 17% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 1t9g chain R Region: 5 - 182 Aligned: 174 Modelled: 178 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase, electron transport Chain: R: PDB Molecule:electron transfer flavoprotein alpha-subunit, PDBTitle: structure of the human mcad:etf complex Phyre2 PDB 1efp chain A domain 1 Region: 6 - 176 Aligned: 166 Modelled: 171 Confidence: 100.0% Identity: 16% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 3fet chain A Region: 2 - 168 Aligned: 156 Modelled: 167 Confidence: 100.0% Identity: 19% PDB header:electron transport Chain: A: PDB Molecule:electron transfer flavoprotein subunit alpha related PDBTitle: crystal structure of the electron transfer flavoprotein subunit alpha2 related protein ta0212 from thermoplasma acidophilum Phyre2 PDB 1efp chain B Region: 8 - 195 Aligned: 185 Modelled: 185 Confidence: 99.9% Identity: 14% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 3cls chain C domain 1 Region: 8 - 220 Aligned: 204 Modelled: 205 Confidence: 99.9% Identity: 11% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 1efv chain B Region: 8 - 220 Aligned: 200 Modelled: 213 Confidence: 99.9% Identity: 17% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 1o94 chain C Region: 8 - 157 Aligned: 147 Modelled: 149 Confidence: 99.8% Identity: 14% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 1t9b chain A domain 1 Region: 191 - 312 Aligned: 119 Modelled: 122 Confidence: 98.8% Identity: 18% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 1ozh chain A domain 1 Region: 195 - 312 Aligned: 118 Modelled: 118 Confidence: 98.7% Identity: 19% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 2ez9 chain A domain 1 Region: 195 - 312 Aligned: 115 Modelled: 118 Confidence: 98.4% Identity: 17% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 2ji7 chain A domain 1 Region: 197 - 312 Aligned: 113 Modelled: 116 Confidence: 98.3% Identity: 17% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 2iht chain A domain 1 Region: 191 - 312 Aligned: 119 Modelled: 122 Confidence: 98.1% Identity: 24% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 1 c1efpC_ 2 d1efva2 3 d1efpa2 4 d3clsd2 5 d3clsd1 6 c1o94D_ 7 c3ih5A_ 8 d1efva1 9 c1t9gR_ 10 d1efpa1 11 c3fetA_ 12 d1efpb_ 13 d3clsc1 14 d1efvb_ 15 d1o94c_ 16 d1t9ba1 17 d1ozha1 18 d2ez9a1 19 d2ji7a1 20 d2ihta1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1efpC_ 100.0 29 PDB header:electron transport Chain: C: PDB Molecule:protein (electron transfer flavoprotein); PDBTitle: electron transfer flavoprotein (etf) from paracoccus2 denitrificans 2 d1efva2 100.0 43 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:C-terminal domain of the electron transfer flavoprotein alpha subunit 3 d1efpa2 100.0 45 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:C-terminal domain of the electron transfer flavoprotein alpha subunit 4 d3clsd2 100.0 37 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:C-terminal domain of the electron transfer flavoprotein alpha subunit 5 d3clsd1 100.0 18 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 6 c1o94D_ 100.0 18 PDB header:electron transport Chain: D: PDB Molecule:electron transfer flavoprotein alpha-subunit; PDBTitle: ternary complex between trimethylamine dehydrogenase and2 electron transferring flavoprotein 7 c3ih5A_ 100.0 22 PDB header:electron transport Chain: A: PDB Molecule:electron transfer flavoprotein alpha-subunit; PDBTitle: crystal structure of electron transfer flavoprotein alpha-2 subunit from bacteroides thetaiotaomicron 8 d1efva1 100.0 17 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 9 c1t9gR_ 100.0 16 PDB header:oxidoreductase, electron transport Chain: R: PDB Molecule:electron transfer flavoprotein alpha-subunit, PDBTitle: structure of the human mcad:etf complex 10 d1efpa1 100.0 16 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 11 c3fetA_ 100.0 19 PDB header:electron transport Chain: A: PDB Molecule:electron transfer flavoprotein subunit alpha related PDBTitle: crystal structure of the electron transfer flavoprotein subunit alpha2 related protein ta0212 from thermoplasma acidophilum 12 d1efpb_ 99.9 14 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 13 d3clsc1 99.9 11 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 14 d1efvb_ 99.9 17 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 15 d1o94c_ 99.8 14 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 16 d1t9ba1 98.8 18 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 17 d1ozha1 98.7 19 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 18 d2ez9a1 98.4 17 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 19 d2ji7a1 98.3 17 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 20 d2ihta1 98.1 24 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 21 c1ozhD_ not modelled 97.8 18 PDB header:lyase Chain: D: PDB Molecule:acetolactate synthase, catabolic; PDBTitle: the crystal structure of klebsiella pneumoniae acetolactate2 synthase with enzyme-bound cofactor and with an unusual3 intermediate. 22 d1ybha1 not modelled 97.7 21 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 23 d1q6za1 not modelled 97.7 16 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 24 c2q27B_ not modelled 97.5 13 PDB header:lyase Chain: B: PDB Molecule:oxalyl-coa decarboxylase; PDBTitle: crystal structure of oxalyl-coa decarboxylase from escherichia coli 25 d2djia1 not modelled 97.5 21 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 26 c1powA_ not modelled 97.4 17 PDB header:oxidoreductase(oxygen as acceptor) Chain: A: PDB Molecule:pyruvate oxidase; PDBTitle: the refined structures of a stabilized mutant and of wild-type2 pyruvate oxidase from lactobacillus plantarum 27 c2djiA_ not modelled 97.3 19 PDB header:oxidoreductase Chain: A: PDB Molecule:pyruvate oxidase; PDBTitle: crystal structure of pyruvate oxidase from aerococcus2 viridans containing fad 28 c2pgnA_ not modelled 97.3 20 PDB header:hydrolase Chain: A: PDB Molecule:cyclohexane-1,2-dione hydrolase (cdh); PDBTitle: the crystal structure of fad and thdp-dependent cyclohexane-1,2-dione2 hydrolase in complex with cyclohexane-1,2-dione 29 c3lq1A_ not modelled 97.3 12 PDB header:transferase Chain: A: PDB Molecule:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene- PDBTitle: crystal structure of 2-succinyl-6-hydroxy-2,4-cyclohexadiene2 1-carboxylic acid synthase/2-oxoglutarate decarboxylase3 from listeria monocytogenes str. 4b f2365 30 c2ji6B_ not modelled 97.3 18 PDB header:lyase Chain: B: PDB Molecule:oxalyl-coa decarboxylase; PDBTitle: x-ray structure of oxalyl-coa decarboxylase in complex with2 3-deaza-thdp and oxalyl-coa 31 c1t9dB_ not modelled 97.1 19 PDB header:transferase Chain: B: PDB Molecule:acetolactate synthase, mitochondrial; PDBTitle: crystal structure of yeast acetohydroxyacid synthase in2 complex with a sulfonylurea herbicide, metsulfuron methyl 32 c1upaC_ not modelled 96.8 20 PDB header:synthase Chain: C: PDB Molecule:carboxyethylarginine synthase; PDBTitle: carboxyethylarginine synthase from streptomyces2 clavuligerus (semet structure) 33 c3eyaE_ not modelled 96.7 24 PDB header:oxidoreductase Chain: E: PDB Molecule:pyruvate dehydrogenase [cytochrome]; PDBTitle: structural basis for membrane binding and catalytic2 activation of the peripheral membrane enzyme pyruvate3 oxidase from escherichia coli 34 c2ag1A_ not modelled 96.7 15 PDB header:lyase Chain: A: PDB Molecule:benzaldehyde lyase; PDBTitle: crystal structure of benzaldehyde lyase (bal)- semet 35 c1yi1A_ not modelled 96.7 20 PDB header:transferase Chain: A: PDB Molecule:acetolactate synthase; PDBTitle: crystal structure of arabidopsis thaliana acetohydroxyacid synthase in2 complex with a sulfonylurea herbicide, tribenuron methyl 36 c2x7jA_ not modelled 96.3 14 PDB header:transferase Chain: A: PDB Molecule:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene PDBTitle: structure of the menaquinone biosynthesis protein mend from2 bacillus subtilis 37 c2panF_ not modelled 96.3 18 PDB header:lyase Chain: F: PDB Molecule:glyoxylate carboligase; PDBTitle: crystal structure of e. coli glyoxylate carboligase 38 d1uana_ not modelled 96.3 15 Fold:LmbE-like Superfamily:LmbE-like Family:LmbE-like 39 d1zpda1 not modelled 96.2 21 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 40 c2v3wC_ not modelled 96.0 16 PDB header:lyase Chain: C: PDB Molecule:benzoylformate decarboxylase; PDBTitle: crystal structure of the benzoylformate decarboxylase2 variant l461a from pseudomonas putida 41 d1m2ka_ not modelled 95.9 26 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 42 d1yc5a1 not modelled 95.8 15 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 43 d1pvda1 not modelled 95.8 13 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 44 c2ixdB_ not modelled 95.6 19 PDB header:hydrolase Chain: B: PDB Molecule:lmbe-related protein; PDBTitle: crystal structure of the putative deacetylase bc1534 from2 bacilus cereus 45 c1jscA_ not modelled 95.2 19 PDB header:lyase Chain: A: PDB Molecule:acetohydroxy-acid synthase; PDBTitle: crystal structure of the catalytic subunit of yeast2 acetohydroxyacid synthase: a target for herbicidal3 inhibitors 46 d2b4ya1 not modelled 95.0 18 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 47 c3k35D_ not modelled 94.8 27 PDB header:hydrolase Chain: D: PDB Molecule:nad-dependent deacetylase sirtuin-6; PDBTitle: crystal structure of human sirt6 48 c3glsC_ not modelled 94.7 27 PDB header:hydrolase Chain: C: PDB Molecule:nad-dependent deacetylase sirtuin-3, PDBTitle: crystal structure of human sirt3 49 c1zpdA_ not modelled 94.6 18 PDB header:alcohol fermentation Chain: A: PDB Molecule:pyruvate decarboxylase; PDBTitle: pyruvate decarboxylase from zymomonas mobilis 50 d1ma3a_ not modelled 94.6 15 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 51 c2jlaD_ not modelled 94.2 14 PDB header:transferase Chain: D: PDB Molecule:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene PDBTitle: crystal structure of e.coli mend, 2-succinyl-5-enolpyruvyl-2 6-hydroxy-3-cyclohexadiene-1-carboxylate synthase - semet3 protein 52 c2dzdB_ not modelled 94.1 13 PDB header:ligase Chain: B: PDB Molecule:pyruvate carboxylase; PDBTitle: crystal structure of the biotin carboxylase domain of2 pyruvate carboxylase 53 c3pkiF_ not modelled 94.0 27 PDB header:hydrolase Chain: F: PDB Molecule:nad-dependent deacetylase sirtuin-6; PDBTitle: human sirt6 crystal structure in complex with adp ribose 54 c2vbiF_ not modelled 93.9 17 PDB header:lyase Chain: F: PDB Molecule:pyruvate decarboxylase; PDBTitle: holostructure of pyruvate decarboxylase from acetobacter2 pasteurianus 55 d1q1aa_ not modelled 93.9 13 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 56 c1q14A_ not modelled 92.8 13 PDB header:hydrolase Chain: A: PDB Molecule:hst2 protein; PDBTitle: structure and autoregulation of the yeast hst2 homolog of sir2 57 d1ovma1 not modelled 92.6 9 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 58 c1ulzA_ not modelled 92.4 13 PDB header:ligase Chain: A: PDB Molecule:pyruvate carboxylase n-terminal domain; PDBTitle: crystal structure of the biotin carboxylase subunit of pyruvate2 carboxylase 59 d1s5pa_ not modelled 92.1 21 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 60 c3ouzA_ not modelled 92.1 8 PDB header:ligase Chain: A: PDB Molecule:biotin carboxylase; PDBTitle: crystal structure of biotin carboxylase-adp complex from campylobacter2 jejuni 61 c2w93A_ not modelled 91.5 19 PDB header:lyase Chain: A: PDB Molecule:pyruvate decarboxylase isozyme 1; PDBTitle: crystal structure of the saccharomyces cerevisiae pyruvate2 decarboxylase variant e477q in complex with the surrogate3 pyruvamide 62 d1j8fa_ not modelled 91.1 30 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 63 c3jwpA_ not modelled 90.9 25 PDB header:transcription Chain: A: PDB Molecule:transcriptional regulatory protein sir2 homologue; PDBTitle: crystal structure of plasmodium falciparum sir2a (pf13_0152) in2 complex with amp 64 c2p10D_ not modelled 89.5 11 PDB header:hydrolase Chain: D: PDB Molecule:mll9387 protein; PDBTitle: crystal structure of a putative phosphonopyruvate hydrolase (mll9387)2 from mesorhizobium loti maff303099 at 2.15 a resolution 65 c2hjhB_ not modelled 89.2 19 PDB header:hydrolase Chain: B: PDB Molecule:nad-dependent histone deacetylase sir2; PDBTitle: crystal structure of the sir2 deacetylase 66 d1tq8a_ not modelled 88.5 15 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:Universal stress protein-like 67 c1ovmC_ not modelled 87.8 11 PDB header:lyase Chain: C: PDB Molecule:indole-3-pyruvate decarboxylase; PDBTitle: crystal structure of indolepyruvate decarboxylase from2 enterobacter cloacae 68 c3dfmA_ not modelled 87.5 14 PDB header:hydrolase Chain: A: PDB Molecule:teicoplanin pseudoaglycone deacetylase orf2; PDBTitle: the crystal structure of the zinc inhibited form of2 teicoplanin deacetylase orf2 69 c2vbgB_ not modelled 87.0 21 PDB header:lyase Chain: B: PDB Molecule:branched-chain alpha-ketoacid decarboxylase; PDBTitle: the complex structure of the branched-chain keto acid2 decarboxylase (kdca) from lactococcus lactis with 2r-1-3 hydroxyethyl-deazathdp 70 c3g8cB_ not modelled 85.9 8 PDB header:ligase Chain: B: PDB Molecule:biotin carboxylase; PDBTitle: crystal stucture of biotin carboxylase in complex with2 biotin, bicarbonate, adp and mg ion 71 c1nvmG_ not modelled 85.6 14 PDB header:lyase/oxidoreductase Chain: G: PDB Molecule:4-hydroxy-2-oxovalerate aldolase; PDBTitle: crystal structure of a bifunctional aldolase-dehydrogenase :2 sequestering a reactive and volatile intermediate 72 c2nxwB_ not modelled 84.9 22 PDB header:lyase Chain: B: PDB Molecule:phenyl-3-pyruvate decarboxylase; PDBTitle: crystal structure of phenylpyruvate decarboxylase of azospirillum2 brasilense 73 d1q74a_ not modelled 84.7 16 Fold:LmbE-like Superfamily:LmbE-like Family:LmbE-like 74 c3dfiA_ not modelled 83.8 14 PDB header:hydrolase Chain: A: PDB Molecule:pseudoaglycone deacetylase dbv21; PDBTitle: the crystal structure of antimicrobial reagent a40926 pseudoaglycone2 deacetylase dbv21 75 c3bg5C_ not modelled 82.4 14 PDB header:ligase Chain: C: PDB Molecule:pyruvate carboxylase; PDBTitle: crystal structure of staphylococcus aureus pyruvate2 carboxylase 76 c3ot5D_ not modelled 82.1 14 PDB header:isomerase Chain: D: PDB Molecule:udp-n-acetylglucosamine 2-epimerase; PDBTitle: 2.2 angstrom resolution crystal structure of putative udp-n-2 acetylglucosamine 2-epimerase from listeria monocytogenes 77 c2gpwC_ not modelled 81.9 9 PDB header:ligase Chain: C: PDB Molecule:biotin carboxylase; PDBTitle: crystal structure of the biotin carboxylase subunit, f363a2 mutant, of acetyl-coa carboxylase from escherichia coli. 78 c2vpqA_ not modelled 81.5 13 PDB header:ligase Chain: A: PDB Molecule:acetyl-coa carboxylase; PDBTitle: crystal structure of biotin carboxylase from s. aureus2 complexed with amppnp 79 c3cf4G_ not modelled 80.5 16 PDB header:oxidoreductase Chain: G: PDB Molecule:acetyl-coa decarboxylase/synthase epsilon subunit; PDBTitle: structure of the codh component of the m. barkeri acds complex 80 d1x94a_ not modelled 80.2 18 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 81 c2x3yA_ not modelled 78.7 13 PDB header:isomerase Chain: A: PDB Molecule:phosphoheptose isomerase; PDBTitle: crystal structure of gmha from burkholderia pseudomallei 82 d1qh8a_ not modelled 76.9 14 Fold:Chelatase-like Superfamily:"Helical backbone" metal receptor Family:Nitrogenase iron-molybdenum protein 83 c2dy0A_ not modelled 72.0 14 PDB header:transferase Chain: A: PDB Molecule:adenine phosphoribosyltransferase; PDBTitle: crystal structure of project jw0458 from escherichia coli 84 d1qh8b_ not modelled 71.4 15 Fold:Chelatase-like Superfamily:"Helical backbone" metal receptor Family:Nitrogenase iron-molybdenum protein 85 d1l1qa_ not modelled 69.7 19 Fold:PRTase-like Superfamily:PRTase-like Family:Phosphoribosyltransferases (PRTases) 86 c3gmiA_ not modelled 69.6 7 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0348 protein mj0951; PDBTitle: crystal structure of a protein of unknown function from2 methanocaldococcus jannaschii 87 d1m1na_ not modelled 69.6 12 Fold:Chelatase-like Superfamily:"Helical backbone" metal receptor Family:Nitrogenase iron-molybdenum protein 88 c3fxaA_ not modelled 68.2 16 PDB header:sugar binding protein Chain: A: PDB Molecule:sis domain protein; PDBTitle: crystal structure of a putative sugar-phosphate isomerase2 (lmof2365_0531) from listeria monocytogenes str. 4b f2365 at 1.60 a3 resolution 89 d1nvma2 not modelled 67.1 14 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:HMGL-like 90 d1tk9a_ not modelled 66.6 18 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 91 c2pn1A_ not modelled 65.9 15 PDB header:ligase Chain: A: PDB Molecule:carbamoylphosphate synthase large subunit; PDBTitle: crystal structure of carbamoylphosphate synthase large subunit (split2 gene in mj) (zp_00538348.1) from exiguobacterium sp. 255-15 at 2.00 a3 resolution 92 c1q7tA_ not modelled 64.8 18 PDB header:hydrolase Chain: A: PDB Molecule:hypothetical protein rv1170; PDBTitle: rv1170 (mshb) from mycobacterium tuberculosis 93 d1miob_ not modelled 63.2 15 Fold:Chelatase-like Superfamily:"Helical backbone" metal receptor Family:Nitrogenase iron-molybdenum protein 94 c1kjjA_ not modelled 61.0 14 PDB header:transferase Chain: A: PDB Molecule:phosphoribosylglycinamide formyltransferase 2; PDBTitle: crystal structure of glycniamide ribonucleotide2 transformylase in complex with mg-atp-gamma-s 95 c3bo9B_ not modelled 60.1 11 PDB header:oxidoreductase Chain: B: PDB Molecule:putative nitroalkan dioxygenase; PDBTitle: crystal structure of putative nitroalkan dioxygenase (tm0800) from2 thermotoga maritima at 2.71 a resolution 96 c2xhzC_ not modelled 60.0 19 PDB header:isomerase Chain: C: PDB Molecule:arabinose 5-phosphate isomerase; PDBTitle: probing the active site of the sugar isomerase domain from e. coli2 arabinose-5-phosphate isomerase via x-ray crystallography 97 c3n6rK_ not modelled 59.7 12 PDB header:ligase Chain: K: PDB Molecule:propionyl-coa carboxylase, alpha subunit; PDBTitle: crystal structure of the holoenzyme of propionyl-coa carboxylase (pcc) 98 d1a9xa4 not modelled 58.4 13 Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:BC N-terminal domain-like 99 c3u9sE_ not modelled 58.2 11 PDB header:ligase Chain: E: PDB Molecule:methylcrotonyl-coa carboxylase, alpha-subunit; PDBTitle: crystal structure of p. aeruginosa 3-methylcrotonyl-coa carboxylase2 (mcc) 750 kd holoenzyme, coa complex 100 c3shoA_ not modelled 56.8 22 PDB header:transcription regulator Chain: A: PDB Molecule:transcriptional regulator, rpir family; PDBTitle: crystal structure of rpir transcription factor from sphaerobacter2 thermophilus (sugar isomerase domain) 101 c3ivuB_ not modelled 54.1 13 PDB header:transferase Chain: B: PDB Molecule:homocitrate synthase, mitochondrial; PDBTitle: homocitrate synthase lys4 bound to 2-og 102 c2gjlA_ not modelled 53.7 12 PDB header:oxidoreductase Chain: A: PDB Molecule:hypothetical protein pa1024; PDBTitle: crystal structure of 2-nitropropane dioxygenase 103 c2ze5A_ not modelled 53.7 22 PDB header:transferase Chain: A: PDB Molecule:isopentenyl transferase; PDBTitle: crystal structure of adenosine phosphate-isopentenyltransferase 104 c1m6vE_ not modelled 53.4 13 PDB header:ligase Chain: E: PDB Molecule:carbamoyl phosphate synthetase large chain; PDBTitle: crystal structure of the g359f (small subunit) point mutant of2 carbamoyl phosphate synthetase 105 d1y0ba1 not modelled 52.6 14 Fold:PRTase-like Superfamily:PRTase-like Family:Phosphoribosyltransferases (PRTases) 106 c3iupB_ not modelled 52.4 17 PDB header:oxidoreductase Chain: B: PDB Molecule:putative nadph:quinone oxidoreductase; PDBTitle: crystal structure of putative nadph:quinone oxidoreductase2 (yp_296108.1) from ralstonia eutropha jmp134 at 1.70 a resolution 107 d2iyva1 not modelled 51.4 28 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Shikimate kinase (AroK) 108 c2dwcB_ not modelled 50.0 15 PDB header:transferase Chain: B: PDB Molecule:433aa long hypothetical phosphoribosylglycinamide formyl PDBTitle: crystal structure of probable phosphoribosylglycinamide formyl2 transferase from pyrococcus horikoshii ot3 complexed with adp 109 c1nriA_ not modelled 49.3 14 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein hi0754; PDBTitle: crystal structure of putative phosphosugar isomerase hi0754 from2 haemophilus influenzae 110 d1nria_ not modelled 49.3 14 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 111 d1rqba2 not modelled 48.5 14 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:HMGL-like 112 c3bg3B_ not modelled 48.2 17 PDB header:ligase Chain: B: PDB Molecule:pyruvate carboxylase, mitochondrial; PDBTitle: crystal structure of human pyruvate carboxylase (missing2 the biotin carboxylase domain at the n-terminus) 113 c3krtC_ not modelled 48.2 12 PDB header:oxidoreductase Chain: C: PDB Molecule:crotonyl coa reductase; PDBTitle: crystal structure of putative crotonyl coa reductase from streptomyces2 coelicolor a3(2) 114 d1g2qa_ not modelled 47.8 11 Fold:PRTase-like Superfamily:PRTase-like Family:Phosphoribosyltransferases (PRTases) 115 c1rr2A_ not modelled 47.4 11 PDB header:transferase Chain: A: PDB Molecule:transcarboxylase 5s subunit; PDBTitle: propionibacterium shermanii transcarboxylase 5s subunit bound to 2-2 ketobutyric acid 116 c1gsoA_ not modelled 46.7 10 PDB header:ligase Chain: A: PDB Molecule:protein (glycinamide ribonucleotide synthetase); PDBTitle: glycinamide ribonucleotide synthetase (gar-syn) from e.2 coli. 117 d1qb7a_ not modelled 44.5 17 Fold:PRTase-like Superfamily:PRTase-like Family:Phosphoribosyltransferases (PRTases) 118 d1a9xa3 not modelled 43.6 15 Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:BC N-terminal domain-like 119 c3ga2A_ not modelled 43.0 13 PDB header:hydrolase Chain: A: PDB Molecule:endonuclease v; PDBTitle: crystal structure of the endonuclease_v (bsu36170) from2 bacillus subtilis, northeast structural genomics3 consortium target sr624 120 d1v4va_ not modelled 42.5 13 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:UDP-N-acetylglucosamine 2-epimerase

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0