Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP24171
DateThu Jan 5 11:40:46 GMT 2012
Unique Job ID815832a9fc64f10f

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c1y791_
Top template information
PDB header:hydrolase
Chain: 1: PDB Molecule:peptidyl-dipeptidase dcp;
PDBTitle: crystal structure of the e.coli dipeptidyl carboxypeptidase2 dcp in complex with a peptidic inhibitor
Confidence and coverage
Confidence:100.0% Coverage:100%
680 residues (100% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MTTMNPFLVQSTLPYLAPHFDQIANHHYRPAFDEGMQQKRAEIAAIALNPQMPDFNNTIL
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Disorder  ???????



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   .........70.........80.........90.........100.........110.........120
Sequence  ALEQSGELLTRVTSVFFAMTAAHTNDELQRLDEQFSAELAELANDIYLNGELFARVDAVW
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   .........130.........140.........150.........160.........170.........180
Sequence  QRRESLGLDSESIRLVEVIHQRFVLAGAKLAQADKAKLKVLNTEAATLTSQFNQRLLAAN
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????



















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?




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   .........190.........200.........210.........220.........230.........240
Sequence  KSGGLVVNDIAQLAGMSEQEIALAAEAAREKGLDNKWLIPLLNTTQQPALAEMRDRATRE
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????????

























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   .........250.........260.........270.........280.........290.........300
Sequence  KLFIAGWTRAEKNDANDTRAIIQRLVEIRAQQATLLGFPHYAAWKIADQMAKTPEAALNF
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???????






























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   .........310.........320.........330.........340.........350.........360
Sequence  MREIVPAARQRASDELASIQAVIDKQQGGFSAQPWDWAFYAEQVRREKFDLDEAQLKPYF
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??????
















?
???


?



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   .........370.........380.........390.........400.........410.........420
Sequence  ELNTVLNEGVFWTANQLFGIKFVERFDIPVYHPDVRVWEIFDHNGVGLALFYGDFFARDS
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   .........430.........440.........450.........460.........470.........480
Sequence  KSGGAWMGNFVEQSTLNKTHPVIYNVCNYQKPAAGEPALLLWDDVITLFHEFGHTLHGLF
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   .........490.........500.........510.........520.........530.........540
Sequence  ARQRYATLSGTNTPRDFVEFPSQINEHWATHPQVFARYARHYQSGAAMPDELQQKMRNAS
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??????












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   .........550.........560.........570.........580.........590.........600
Sequence  LFNKGYEMSELLSAALLDMRWHCLEENEAMQDVDDFELRALVAENMDLPAIPPRYRSSYF
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???































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   .........610.........620.........630.........640.........650.........660
Sequence  AHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGLRFREAILSRGNSEDLERLY
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   .........670.........680.
Sequence  RQWRGKAPKIMPMLQHRGLNI
Secondary structure 










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Disorder 















?
???
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1y79 chain 1

3D model

Region: 2 - 681
Aligned: 680
Modelled: 680
Confidence: 100.0%
Identity: 100%
PDB header:hydrolase
Chain: 1: PDB Molecule:peptidyl-dipeptidase dcp;
PDBTitle: crystal structure of the e.coli dipeptidyl carboxypeptidase2 dcp in complex with a peptidic inhibitor

Phyre2

PDB 1i1i chain P

3D model

Region: 8 - 679
Aligned: 653
Modelled: 672
Confidence: 100.0%
Identity: 24%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Neurolysin-like

Phyre2

PDB 1s4b chain P

3D model

Region: 11 - 679
Aligned: 640
Modelled: 669
Confidence: 100.0%
Identity: 27%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Neurolysin-like

Phyre2

PDB 3ce2 chain A

3D model

Region: 6 - 676
Aligned: 561
Modelled: 605
Confidence: 100.0%
Identity: 12%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:putative peptidase;
PDBTitle: crystal structure of putative peptidase from chlamydophila abortus

Phyre2

PDB 2h1j chain A

3D model

Region: 19 - 677
Aligned: 539
Modelled: 579
Confidence: 100.0%
Identity: 15%
PDB header:hydrolase
Chain: A: PDB Molecule:oligoendopeptidase f;
PDBTitle: 3.1 a x-ray structure of putative oligoendopeptidase f: crystals grown2 by microfluidic seeding

Phyre2

PDB 3sks chain A

3D model

Region: 4 - 677
Aligned: 526
Modelled: 528
Confidence: 100.0%
Identity: 16%
PDB header:hydrolase
Chain: A: PDB Molecule:putative oligoendopeptidase f;
PDBTitle: crystal structure of a putative oligoendopeptidase f from bacillus2 anthracis str. ames

Phyre2

PDB 2ajf chain A domain 1

3D model

Region: 55 - 676
Aligned: 528
Modelled: 563
Confidence: 100.0%
Identity: 12%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Neurolysin-like

Phyre2

PDB 1uze chain A

3D model

Region: 51 - 676
Aligned: 534
Modelled: 578
Confidence: 100.0%
Identity: 11%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Neurolysin-like

Phyre2

PDB 2c6n chain A

3D model

Region: 49 - 676
Aligned: 545
Modelled: 581
Confidence: 100.0%
Identity: 12%
PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:angiotensin-converting enzyme, somatic isoform;
PDBTitle: structure of human somatic angiontensin-i converting enzyme n domain2 with lisinopril

Phyre2

PDB 2qr4 chain B

3D model

Region: 29 - 676
Aligned: 477
Modelled: 516
Confidence: 100.0%
Identity: 16%
PDB header:hydrolase
Chain: B: PDB Molecule:peptidase m3b, oligoendopeptidase f;
PDBTitle: crystal structure of oligoendopeptidase-f from enterococcus faecium

Phyre2

PDB 1j36 chain A

3D model

Region: 56 - 677
Aligned: 522
Modelled: 556
Confidence: 100.0%
Identity: 15%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Neurolysin-like

Phyre2

PDB 1wgz chain C

3D model

Region: 54 - 677
Aligned: 463
Modelled: 484
Confidence: 100.0%
Identity: 16%
PDB header:hydrolase
Chain: C: PDB Molecule:carboxypeptidase 1;
PDBTitle: crystal structure of carboxypeptidase 1 from thermus thermophilus

Phyre2

PDB 1k9x chain A

3D model

Region: 57 - 677
Aligned: 461
Modelled: 484
Confidence: 100.0%
Identity: 15%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Neurolysin-like

Phyre2

PDB 3dwc chain A

3D model

Region: 60 - 677
Aligned: 459
Modelled: 484
Confidence: 100.0%
Identity: 15%
PDB header:hydrolase
Chain: A: PDB Molecule:metallocarboxypeptidase;
PDBTitle: trypanosoma cruzi metallocarboxypeptidase 1

Phyre2

PDB 3hq2 chain A

3D model

Region: 54 - 677
Aligned: 462
Modelled: 483
Confidence: 100.0%
Identity: 15%
PDB header:hydrolase
Chain: A: PDB Molecule:bacillus subtilis m32 carboxypeptidase;
PDBTitle: bsucp crystal structure

Phyre2

PDB 1g9k chain A domain 2

3D model

Region: 356 - 476
Aligned: 97
Modelled: 105
Confidence: 96.3%
Identity: 20%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Serralysin-like metalloprotease, catalytic (N-terminal) domain

Phyre2

PDB 1kap chain P domain 2

3D model

Region: 356 - 476
Aligned: 98
Modelled: 101
Confidence: 96.1%
Identity: 23%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Serralysin-like metalloprotease, catalytic (N-terminal) domain

Phyre2

PDB 1om8 chain A

3D model

Region: 356 - 476
Aligned: 98
Modelled: 106
Confidence: 95.5%
Identity: 19%
PDB header:hydrolase
Chain: A: PDB Molecule:serralysin;
PDBTitle: crystal structure of a cold adapted alkaline protease from pseudomonas2 tac ii 18, co-crystallyzed with 10 mm edta

Phyre2

PDB 1cgl chain A

3D model

Region: 364 - 476
Aligned: 94
Modelled: 96
Confidence: 95.5%
Identity: 13%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Matrix metalloproteases, catalytic domain

Phyre2

PDB 1j7n chain A domain 2

3D model

Region: 463 - 506
Aligned: 44
Modelled: 44
Confidence: 95.4%
Identity: 23%
Fold: Zincin-like
Superfamily: Metalloproteases ("zincins"), catalytic domain
Family: Anthrax toxin lethal factor, N- and C-terminal domains

Phyre2
1

c1y791_
2

d1i1ip_
3

d1s4bp_
4

c3ce2A_
5

c2h1jA_
6

c3sksA_
7

d2ajfa1
8

d1uzea_
9

c2c6nA_
10

c2qr4B_
11

d1j36a_
12

c1wgzC_
13

d1k9xa_
14

c3dwcA_
15

c3hq2A_
16

d1g9ka2
17

d1kapp2
18

c1om8A_
19

d1cgla_
20

d1j7na2
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c1y791_



100.0 100 PDB header:hydrolase
Chain: 1: PDB Molecule:peptidyl-dipeptidase dcp;
PDBTitle: crystal structure of the e.coli dipeptidyl carboxypeptidase2 dcp in complex with a peptidic inhibitor
2d1i1ip_



100.0 24 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Neurolysin-like
3d1s4bp_



100.0 27 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Neurolysin-like
4c3ce2A_



100.0 12 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:putative peptidase;
PDBTitle: crystal structure of putative peptidase from chlamydophila abortus
5c2h1jA_



100.0 15 PDB header:hydrolase
Chain: A: PDB Molecule:oligoendopeptidase f;
PDBTitle: 3.1 a x-ray structure of putative oligoendopeptidase f: crystals grown2 by microfluidic seeding
6c3sksA_



100.0 16 PDB header:hydrolase
Chain: A: PDB Molecule:putative oligoendopeptidase f;
PDBTitle: crystal structure of a putative oligoendopeptidase f from bacillus2 anthracis str. ames
7d2ajfa1



100.0 12 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Neurolysin-like
8d1uzea_



100.0 11 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Neurolysin-like
9c2c6nA_



100.0 12 PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:angiotensin-converting enzyme, somatic isoform;
PDBTitle: structure of human somatic angiontensin-i converting enzyme n domain2 with lisinopril
10c2qr4B_



100.0 16 PDB header:hydrolase
Chain: B: PDB Molecule:peptidase m3b, oligoendopeptidase f;
PDBTitle: crystal structure of oligoendopeptidase-f from enterococcus faecium
11d1j36a_



100.0 15 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Neurolysin-like
12c1wgzC_



100.0 16 PDB header:hydrolase
Chain: C: PDB Molecule:carboxypeptidase 1;
PDBTitle: crystal structure of carboxypeptidase 1 from thermus thermophilus
13d1k9xa_



100.0 15 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Neurolysin-like
14c3dwcA_



100.0 15 PDB header:hydrolase
Chain: A: PDB Molecule:metallocarboxypeptidase;
PDBTitle: trypanosoma cruzi metallocarboxypeptidase 1
15c3hq2A_



100.0 15 PDB header:hydrolase
Chain: A: PDB Molecule:bacillus subtilis m32 carboxypeptidase;
PDBTitle: bsucp crystal structure
16d1g9ka2



96.3 20 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain
17d1kapp2



96.1 23 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain
18c1om8A_



95.5 19 PDB header:hydrolase
Chain: A: PDB Molecule:serralysin;
PDBTitle: crystal structure of a cold adapted alkaline protease from pseudomonas2 tac ii 18, co-crystallyzed with 10 mm edta
19d1cgla_



95.5 13 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
20d1j7na2



95.4 23 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Anthrax toxin lethal factor, N- and C-terminal domains
21d1k7ia2



not modelled 95.4 13 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain
22c1jiwP_



not modelled 95.3 21 PDB header:hydrolase/hyrolase inhibitor
Chain: P: PDB Molecule:alkaline metalloproteinase;
PDBTitle: crystal structure of the apr-aprin complex
23d1hfca_



not modelled 94.9 13 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
24d2ovxa1



not modelled 94.8 10 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
25d1hv5a_



not modelled 94.7 17 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
26c1pwqA_



not modelled 94.6 22 PDB header:hydrolase
Chain: A: PDB Molecule:lethal factor;
PDBTitle: crystal structure of anthrax lethal factor complexed with2 thioacetyl-tyr-pro-met-amide, a metal-chelating peptidyl3 small molecule inhibitor
27d1sata2



not modelled 94.4 12 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain
28d1hova_



not modelled 94.4 15 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
29c1yqyA_



not modelled 94.3 32 PDB header:hydrolase
Chain: A: PDB Molecule:lethal factor;
PDBTitle: structure of b. anthrax lethal factor in complex with a2 hydroxamate inhibitor
30d1bqqm_



not modelled 93.9 14 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
31d1hy7a_



not modelled 93.9 12 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
32d1cxva_



not modelled 93.8 13 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
33d1mmqa_



not modelled 93.8 13 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
34d1q3aa_



not modelled 93.5 11 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
35c3edhA_



not modelled 93.5 17 PDB header:hydrolase
Chain: A: PDB Molecule:bone morphogenetic protein 1;
PDBTitle: crystal structure of bone morphogenetic protein 1 protease2 domain in complex with partially bound dmso
36d1qiba_



not modelled 93.5 13 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
37d1y93a1



not modelled 93.5 14 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
38c1su3A_



not modelled 93.3 12 PDB header:hydrolase
Chain: A: PDB Molecule:interstitial collagenase;
PDBTitle: x-ray structure of human prommp-1: new insights into2 collagenase action
39d1xuca1



not modelled 93.1 12 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
40c2l0rA_



not modelled 92.9 35 PDB header:hydrolase,toxin
Chain: A: PDB Molecule:lethal factor;
PDBTitle: conformational dynamics of the anthrax lethal factor catalytic center
41c2xhqA_



not modelled 92.9 17 PDB header:hydrolase
Chain: A: PDB Molecule:archaemetzincin;
PDBTitle: crystal structure of archaemetzincin (amza) from archaeoglobus2 fulgidus at 1.45 a resolution
42d1i76a_



not modelled 92.7 15 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
43d1rm8a_



not modelled 92.3 15 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
44d1asta_



not modelled 92.3 16 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Astacin
45c3dtkA_



not modelled 92.0 41 PDB header:gene regulation
Chain: A: PDB Molecule:irre protein;
PDBTitle: crystal structure of the irre protein, a central regulator2 of dna damage repair in deinococcaceae
46d1fbla2



not modelled 91.6 14 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
47c2cltB_



not modelled 91.2 11 PDB header:hydrolase
Chain: B: PDB Molecule:interstitial collagenase;
PDBTitle: crystal structure of the active form (full-length) of human2 fibroblast collagenase.
48c3lq0A_



not modelled 91.2 15 PDB header:hydrolase
Chain: A: PDB Molecule:proastacin;
PDBTitle: zymogen structure of crayfish astacin metallopeptidase
49c2xs4A_



not modelled 91.1 42 PDB header:hydrolase
Chain: A: PDB Molecule:karilysin protease;
PDBTitle: structure of karilysin catalytic mmp domain in complex with2 magnesium
50c2jsdA_



not modelled 91.1 18 PDB header:hydrolase
Chain: A: PDB Molecule:matrix metalloproteinase-20;
PDBTitle: solution structure of mmp20 complexed with nngh
51c3k7lA_



not modelled 90.5 25 PDB header:hydrolase
Chain: A: PDB Molecule:atragin;
PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins
52c3lqbA_



not modelled 90.5 20 PDB header:hydrolase
Chain: A: PDB Molecule:loc792177 protein;
PDBTitle: crystal structure of the hatching enzyme zhe1 from the zebrafish danio2 rerio
53c3o0yC_



not modelled 90.4 13 PDB header:lipid binding protein
Chain: C: PDB Molecule:lipoprotein;
PDBTitle: the crystal structure of the putative lipoprotein from colwellia2 psychrerythraea
54d1kufa_



not modelled 89.5 24 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
55d1quaa_



not modelled 89.5 15 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
56c3nqzB_



not modelled 89.2 15 PDB header:hydrolase
Chain: B: PDB Molecule:secreted metalloprotease mcp02;
PDBTitle: crystal structure of the autoprocessed vibriolysin mcp-02 with e369a2 mutation
57d1eaka2



not modelled 88.8 33 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Matrix metalloproteases, catalytic domain
58d1atla_



not modelled 88.8 24 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
59d2i47a1



not modelled 88.2 25 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:TNF-alpha converting enzyme, TACE, catalytic domain
60d1nd1a_



not modelled 88.2 24 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
61c2i47A_



not modelled 88.1 25 PDB header:hydrolase
Chain: A: PDB Molecule:adam 17;
PDBTitle: crystal structure of catalytic domain of tace with inhibitor
62c1zb7A_



not modelled 87.9 31 PDB header:toxin
Chain: A: PDB Molecule:neurotoxin;
PDBTitle: crystal structure of botulinum neurotoxin type g light chain
63d1kjpa_



not modelled 87.9 19 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Thermolysin-like
64c2erpA_



not modelled 87.8 23 PDB header:toxin
Chain: A: PDB Molecule:vascular apoptosis-inducing protein 1;
PDBTitle: crystal structure of vascular apoptosis-inducing protein-1(inhibitor-2 bound form)
65c1yp1A_



not modelled 87.8 13 PDB header:hydrolase
Chain: A: PDB Molecule:fii;
PDBTitle: crystal structure of a non-hemorrhagic fibrin(ogen)olytic2 metalloproteinase from venom of agkistrodon acutus
66c2vqxA_



not modelled 87.7 11 PDB header:hydrolase
Chain: A: PDB Molecule:metalloproteinase;
PDBTitle: precursor of protealysin, metalloproteinase from serratia2 proteamaculans.
67d4aiga_



not modelled 87.4 17 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
68c1satA_



not modelled 87.3 12 PDB header:hydrolase (serine protease)
Chain: A: PDB Molecule:serratia protease;
PDBTitle: crystal structure of the 50 kda metallo protease from s.2 marcescens
69d1r55a_



not modelled 87.3 16 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
70c3ba0A_



not modelled 87.0 55 PDB header:hydrolase
Chain: A: PDB Molecule:macrophage metalloelastase;
PDBTitle: crystal structure of full-length human mmp-12
71d1bswa_



not modelled 86.4 20 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
72c1slmA_



not modelled 86.3 42 PDB header:hydrolase
Chain: A: PDB Molecule:stromelysin-1;
PDBTitle: crystal structure of fibroblast stromelysin-1: the c-truncated human2 proenzyme
73d1npca_



not modelled 86.3 15 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Thermolysin-like
74c2dw1B_



not modelled 85.7 33 PDB header:apoptosis, toxin
Chain: B: PDB Molecule:catrocollastatin;
PDBTitle: crystal structure of vap2 from crotalus atrox venom (form 2-2 crystal)
75c3nqxA_



not modelled 85.6 15 PDB header:hydrolase
Chain: A: PDB Molecule:secreted metalloprotease mcp02;
PDBTitle: crystal structure of vibriolysin mcp-02 mature enzyme, a zinc2 metalloprotease from m4 family
76d1u4ga_



not modelled 85.4 16 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Thermolysin-like
77c3b8zB_



not modelled 85.0 46 PDB header:hydrolase
Chain: B: PDB Molecule:protein adamts-5;
PDBTitle: high resolution crystal structure of the catalytic domain2 of adamts-5 (aggrecanase-2)
78d1wnia_



not modelled 85.0 40 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Reprolysin-like
79c3k7nA_



not modelled 84.4 23 PDB header:hydrolase
Chain: A: PDB Molecule:k-like;
PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins
80c3g5cA_



not modelled 84.4 23 PDB header:membrane protein
Chain: A: PDB Molecule:adam 22;
PDBTitle: structural and biochemical studies on the ectodomain of human adam22
81c2fpqA_



not modelled 83.4 22 PDB header:toxin
Chain: A: PDB Molecule:botulinum neurotoxin d light chain;
PDBTitle: crystal structure of botulinum neurotoxin type d light chain
82c2rjqA_



not modelled 82.8 38 PDB header:hydrolase
Chain: A: PDB Molecule:adamts-5;
PDBTitle: crystal structure of adamts5 with inhibitor bound
83d1epwa3



not modelled 82.3 50 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Clostridium neurotoxins, catalytic domain
84c3k3qB_



not modelled 82.2 44 PDB header:immune system
Chain: B: PDB Molecule:botulinum neurotoxin type a;
PDBTitle: crystal structure of a llama antibody complexed with the c.2 botulinum neurotoxin serotype a catalytic domain
85c1z7hA_



not modelled 82.1 50 PDB header:hydrolase
Chain: A: PDB Molecule:tetanus toxin light chain;
PDBTitle: 2.3 angstrom crystal structure of tetanus neurotoxin light2 chain
86d1f83a_



not modelled 82.1 50 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Clostridium neurotoxins, catalytic domain
87c1e1hC_



not modelled 82.0 44 PDB header:hydrolase
Chain: C: PDB Molecule:botulinum neurotoxin type a light chain;
PDBTitle: crystal structure of recombinant botulinum neurotoxin type2 a light chain, self-inhibiting zn endopeptidase.
88c2e3xA_



not modelled 82.0 19 PDB header:hydrolase, blood clotting, toxin
Chain: A: PDB Molecule:coagulation factor x-activating enzyme heavy chain;
PDBTitle: crystal structure of russell's viper venom metalloproteinase
89c2qn0A_



not modelled 81.9 38 PDB header:toxin
Chain: A: PDB Molecule:neurotoxin;
PDBTitle: structure of botulinum neurotoxin serotype c1 light chain2 protease
90d3bona1



not modelled 81.8 44 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Clostridium neurotoxins, catalytic domain
91d3btaa3



not modelled 81.2 44 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Clostridium neurotoxins, catalytic domain
92d1t3ca_



not modelled 81.1 50 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Clostridium neurotoxins, catalytic domain
93c2a97B_



not modelled 81.0 56 PDB header:hydrolase
Chain: B: PDB Molecule:botulinum neurotoxin type f;
PDBTitle: crystal structure of catalytic domain of clostridium2 botulinum neurotoxin serotype f
94c2ilpA_



not modelled 81.0 44 PDB header:hydrolase
Chain: A: PDB Molecule:botulinum neurotoxin a light-chain;
PDBTitle: clostridium botulinum serotype a light chain inhibited by 4-2 chlorocinnamic hydroxamate
95c2rjpC_



not modelled 80.8 25 PDB header:hydrolase
Chain: C: PDB Molecule:adamts-4;
PDBTitle: crystal structure of adamts4 with inhibitor bound
96c2xhlA_



not modelled 80.2 50 PDB header:hydrolase
Chain: A: PDB Molecule:botulinum neurotoxin b light chain;
PDBTitle: structure of a functional derivative of clostridium2 botulinum neurotoxin type b
97c2j83B_



not modelled 80.2 56 PDB header:hydrolase
Chain: B: PDB Molecule:ulilysin;
PDBTitle: ulilysin metalloprotease in complex with batimastat.
98c2x7mA_



not modelled 79.8 27 PDB header:hydrolase
Chain: A: PDB Molecule:archaemetzincin;
PDBTitle: crystal structure of archaemetzincin (amza) from methanopyrus2 kandleri at 1.5 a resolution
99c3b4rB_



not modelled 79.3 42 PDB header:hydrolase
Chain: B: PDB Molecule:putative zinc metalloprotease mj0392;
PDBTitle: site-2 protease from methanocaldococcus jannaschii
100c2v4bB_



not modelled 79.2 31 PDB header:hydrolase
Chain: B: PDB Molecule:adamts-1;
PDBTitle: crystal structure of human adamts-1 catalytic domain and2 cysteine-rich domain (apo-form)
101c3zuqA_



not modelled 78.3 50 PDB header:hydrolase
Chain: A: PDB Molecule:botulinum neurotoxin type b;
PDBTitle: crystal structure of an engineered botulinum neurotoxin2 type b-derivative, lc-b-gs-hn-b
102c3zusD_



not modelled 78.3 44 PDB header:hydrolase/signaling protein
Chain: D: PDB Molecule:botulinum neurotoxin type a, synaptosomal-associated
PDBTitle: crystal structure of an engineered botulinum neurotoxin2 type a-snare23 derivative, lc-a-snap23-hn-a
103c3ffzA_



not modelled 77.5 56 PDB header:hydrolase
Chain: A: PDB Molecule:botulinum neurotoxin type e;
PDBTitle: domain organization in clostridium butulinum neurotoxin2 type e is unique: its implication in faster translocation
104c3p24C_



not modelled 77.1 50 PDB header:hydrolase
Chain: C: PDB Molecule:bft-3;
PDBTitle: structure of profragilysin-3 from bacteroides fragilis
105d2ejqa1



not modelled 76.8 39 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:TTHA0227-like
106d1bqba_



not modelled 76.4 22 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Thermolysin-like
107c3cqbB_



not modelled 75.1 33 PDB header:hydrolase
Chain: B: PDB Molecule:probable protease htpx homolog;
PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633
108c2nyyA_



not modelled 74.9 44 PDB header:toxin/immune system
Chain: A: PDB Molecule:botulinum neurotoxin type a;
PDBTitle: crystal structure of botulinum neurotoxin type a complexed with2 monoclonal antibody cr1
109c1s0bA_



not modelled 74.5 50 PDB header:toxin, hydrolase
Chain: A: PDB Molecule:botulinum neurotoxin type b;
PDBTitle: crystal structure of botulinum neurotoxin type b at ph 4.0
110c3zurA_



not modelled 72.8 31 PDB header:hydrolase/signaling protein
Chain: A: PDB Molecule:botulinum neurotoxin type a, synaptosomal-associated
PDBTitle: crystal structure of an engineered botulinum neurotoxin2 type a-snare23 derivative, lc0-a-snap25-hn-a
111c3dl1A_



not modelled 71.5 20 PDB header:hydrolase
Chain: A: PDB Molecule:putative metal-dependent hydrolase;
PDBTitle: crystal structure of a putative metal-dependent hydrolase2 (yp_001336084.1) from klebsiella pneumoniae subsp. pneumoniae mgh3 78578 at 2.20 a resolution
112c1eakA_



not modelled 71.1 33 PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:72 kda type iv collagenase;
PDBTitle: catalytic domain of prommp-2 e404q mutant
113c3c37B_



not modelled 70.1 33 PDB header:hydrolase
Chain: B: PDB Molecule:peptidase, m48 family;
PDBTitle: x-ray structure of the putative zn-dependent peptidase q74d82 at the2 resolution 1.7 a. northeast structural genomics consortium target3 gsr143a
114d1lmla_



not modelled 69.9 25 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Leishmanolysin
115d1c7ka_



not modelled 65.9 40 Fold:Zincin-like
Superfamily:Metalloproteases ("zincins"), catalytic domain
Family:Zinc protease
116c3p1vB_



not modelled 64.3 50 PDB header:hydrolase
Chain: B: PDB Molecule:metallo-endopeptidase;
PDBTitle: crystal structure of a metallo-endopeptidases (bacova_00663) from2 bacteroides ovatus at 1.93 a resolution
117c1l6jA_



not modelled 58.6 50 PDB header:hydrolase
Chain: A: PDB Molecule:matrix metalloproteinase-9;
PDBTitle: crystal structure of human matrix metalloproteinase mmp92 (gelatinase b).
118c1gxdA_



not modelled 53.8 33 PDB header:hydrolase
Chain: A: PDB Molecule:72 kda type iv collagenase;
PDBTitle: prommp-2/timp-2 complex
119c3lmcA_



not modelled 50.4 26 PDB header:hydrolase
Chain: A: PDB Molecule:peptidase, zinc-dependent;
PDBTitle: crystal structure of zinc-dependent peptidase from methanocorpusculum2 labreanum (strain z), northeast structural genomics consortium target3 mur16
120c3cskA_



not modelled 45.0 42 PDB header:hydrolase
Chain: A: PDB Molecule:probable dipeptidyl-peptidase 3;
PDBTitle: structure of dpp iii from saccharomyces cerevisiae

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0