Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	I	C	L	I	D	E	T	G	T	G	D	G	A	L	S	V	L	A	A	R	W	G	L	E	H	D	E	D	N	L	M	A	L	V	L	T	P	E	H	L	E	L	R	K	R	D	E	P	K	L	G	G	I	F	V	D	F	V
Secondary structure
SS confidence
Disorder		?					?	?											?	?																												?		?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	G	A	M	A	H	R	R	K	F	G	G	G	R	G	E	A	V	A	K	A	V	G	I	K	G	D	Y	L	P	D	V	V	D	A	T	A	G	L	G	R	D	A	F	V	L	A	S	V	G	C	R	V	R	M	L	E	R	N	P
Secondary structure
SS confidence
Disorder					?					?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	V	A	A	L	L	D	D	G	L	A	R	G	Y	A	D	A	E	I	G	G	W	L	Q	E	R	L	Q	L	I	H	A	S	S	L	T	A	L	T	D	I	T	P	R	P	Q	V	V	Y	L	D	P	M	F	P	H	K	Q	K	S
Secondary structure
SS confidence
Disorder															?	?																																										?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	L	V	K	K	E	M	R	V	F	Q	S	L	V	G	P	D	L	D	A	D	G	L	L	E	P	A	R	L	L	A	T	K	R	V	V	V	K	R	P	D	Y	A	P	P	L	A	N	V	A	T	P	N	A	V	V	T	K	G	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																																						?	?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250
Sequence		R	F	D	I	Y	A	G	T	P	V
Secondary structure
SS confidence
Disorder							?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2pkw chain A domain 1 Region: 1 - 250 Aligned: 250 Modelled: 249 Confidence: 100.0% Identity: 92% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: YhiQ-like Phyre2 PDB 2oyr chain A domain 1 Region: 1 - 250 Aligned: 245 Modelled: 249 Confidence: 100.0% Identity: 97% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: YhiQ-like Phyre2 PDB 2r6z chain A Region: 4 - 248 Aligned: 210 Modelled: 215 Confidence: 100.0% Identity: 40% PDB header:transferase Chain: A: PDB Molecule:upf0341 protein in rsp 3' region; PDBTitle: crystal structure of the sam-dependent methyltransferase2 ngo1261 from neisseria gonorrhoeae, northeast structural3 genomics consortium target ngr48 Phyre2 PDB 3ll7 chain A Region: 77 - 218 Aligned: 119 Modelled: 142 Confidence: 99.7% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:putative methyltransferase; PDBTitle: crystal structure of putative methyltransferase pg_1098 from2 porphyromonas gingivalis w83 Phyre2 PDB 3gdh chain C Region: 76 - 224 Aligned: 131 Modelled: 149 Confidence: 99.3% Identity: 21% PDB header:transferase Chain: C: PDB Molecule:trimethylguanosine synthase homolog; PDBTitle: methyltransferase domain of human trimethylguanosine2 synthase 1 (tgs1) bound to m7gtp and adenosyl-homocysteine3 (active form) Phyre2 PDB 3egi chain A Region: 76 - 222 Aligned: 124 Modelled: 147 Confidence: 99.3% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:trimethylguanosine synthase homolog; PDBTitle: methyltransferase domain of human trimethylguanosine2 synthase tgs1 bound to m7gpppa (inactive form) Phyre2 PDB 2fpo chain A domain 1 Region: 91 - 176 Aligned: 77 Modelled: 86 Confidence: 99.3% Identity: 23% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: YhhF-like Phyre2 PDB 1uwv chain A domain 2 Region: 35 - 174 Aligned: 117 Modelled: 134 Confidence: 99.3% Identity: 17% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: (Uracil-5-)-methyltransferase Phyre2 PDB 3c0k chain B Region: 27 - 210 Aligned: 150 Modelled: 184 Confidence: 99.2% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:upf0064 protein yccw; PDBTitle: crystal structure of a ribosomal rna methyltranferase Phyre2 PDB 2igt chain A domain 1 Region: 29 - 194 Aligned: 147 Modelled: 164 Confidence: 99.2% Identity: 12% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: hypothetical RNA methyltransferase Phyre2 PDB 1wxw chain A Region: 80 - 180 Aligned: 90 Modelled: 101 Confidence: 99.2% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:hypothetical protein ttha1280; PDBTitle: crystal structure of tt1595, a putative sam-dependent2 methyltransferase from thermus thermophillus hb8 Phyre2 PDB 1uwv chain A Region: 58 - 173 Aligned: 100 Modelled: 110 Confidence: 99.1% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:23s rrna (uracil-5-)-methyltransferase ruma; PDBTitle: crystal structure of ruma, the iron-sulfur cluster2 containing e. coli 23s ribosomal rna 5-methyluridine3 methyltransferase Phyre2 PDB 2b78 chain A Region: 27 - 174 Aligned: 126 Modelled: 137 Confidence: 99.1% Identity: 10% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein smu.776; PDBTitle: a putative sam-dependent methyltransferase from2 streptococcus mutans Phyre2 PDB 2as0 chain A Region: 29 - 181 Aligned: 129 Modelled: 139 Confidence: 99.1% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:hypothetical protein ph1915; PDBTitle: crystal structure of ph1915 (apc 5817): a hypothetical rna2 methyltransferase Phyre2 PDB 2as0 chain A domain 2 Region: 84 - 181 Aligned: 88 Modelled: 98 Confidence: 99.1% Identity: 18% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: hypothetical RNA methyltransferase Phyre2 PDB 1nv8 chain A Region: 76 - 210 Aligned: 125 Modelled: 135 Confidence: 99.1% Identity: 13% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: N5-glutamine methyltransferase, HemK Phyre2 PDB 2fhp chain A domain 1 Region: 91 - 174 Aligned: 76 Modelled: 83 Confidence: 99.1% Identity: 22% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: YhhF-like Phyre2 PDB 2esr chain A domain 1 Region: 75 - 174 Aligned: 90 Modelled: 100 Confidence: 99.1% Identity: 26% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: YhhF-like Phyre2 PDB 2esr chain B Region: 75 - 174 Aligned: 91 Modelled: 100 Confidence: 99.0% Identity: 26% PDB header:transferase Chain: B: PDB Molecule:methyltransferase; PDBTitle: conserved hypothetical protein- streptococcus pyogenes Phyre2 PDB 1wxx chain A domain 2 Region: 29 - 180 Aligned: 126 Modelled: 152 Confidence: 99.0% Identity: 13% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: hypothetical RNA methyltransferase Phyre2 1 d2pkwa1 2 d2oyra1 3 c2r6zA_ 4 c3ll7A_ 5 c3gdhC_ 6 c3egiA_ 7 d2fpoa1 8 d1uwva2 9 c3c0kB_ 10 d2igta1 11 c1wxwA_ 12 c1uwvA_ 13 c2b78A_ 14 c2as0A_ 15 d2as0a2 16 d1nv8a_ 17 d2fhpa1 18 d2esra1 19 c2esrB_ 20 d1wxxa2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480