Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	Q	I	D	F	R	K	K	I	N	W	H	R	R	Y	R	S	P	Q	G	V	K	T	E	H	E	I	L	R	I	F	E	S	D	R	G	R	I	I	N	S	P	A	I	R	R	L	Q	Q	K	T	Q	V	F	P	L	E	R	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	A	V	R	T	R	L	T	H	S	M	E	V	Q	Q	V	G	R	Y	I	A	K	E	I	L	S	R	L	K	E	L	K	L	L	E	A	Y	G	L	D	E	L	T	G	P	F	E	S	I	V	E	M	S	C	L	M	H	D	I	G
Secondary structure
SS confidence
Disorder																																?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		N	P	P	F	G	H	F	G	E	A	A	I	N	D	W	F	R	Q	R	L	H	P	E	D	A	E	S	Q	P	L	T	D	D	R	C	S	V	A	A	L	R	L	R	D	G	E	E	P	L	N	E	L	R	R	K	I	R	Q	D	L
Secondary structure
SS confidence
Disorder																							?	?	?	?	?	?		?	?	?	?	?	?	?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		C	H	F	E	G	N	A	Q	G	I	R	L	V	H	T	L	M	R	M	N	L	T	W	A	Q	V	G	G	I	L	K	Y	T	R	P	A	W	W	R	G	E	T	P	E	T	H	H	Y	L	M	K	K	P	G	Y	Y	L	S	E	E
Secondary structure
SS confidence
Disorder					?																																?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	Y	I	A	R	L	R	K	E	L	N	L	A	L	Y	S	R	F	P	L	T	W	I	M	E	A	A	D	D	I	S	Y	C	V	A	D	L	E	D	A	V	E	K	R	I	F	T	V	E	Q	L	Y	H	H	L	H	E	A	W	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Q	H	E	K	G	S	L	F	S	L	V	V	E	N	A	W	E	K	S	R	S	N	S	L	S	R	S	T	E	D	Q	F	F	M	Y	L	R	V	N	T	L	N	K	L	V	P	Y	A	A	Q	R	F	I	D	N	L	P	A	I	F
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	G	T	F	N	H	A	L	L	E	D	A	S	E	C	S	D	L	L	K	L	Y	K	N	V	A	V	K	H	V	F	S	H	P	D	V	E	R	L	E	L	Q	G	Y	R	V	I	S	G	L	L	E	I	Y	R	P	L	L	S	L
Secondary structure
SS confidence
Disorder																																																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		S	L	S	D	F	T	E	L	V	E	K	E	R	V	K	R	F	P	I	E	S	R	L	F	H	K	L	S	T	R	H	R	L	A	Y	V	E	A	V	S	K	L	P	S	D	S	P	E	F	P	L	W	E	Y	Y	Y	R	C	R	L
Secondary structure
SS confidence
Disorder		?				?									?	?																								?	?	?	?			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.
Sequence		L	Q	D	Y	I	S	G	M	T	D	L	Y	A	W	D	E	Y	R	R	L	M	A	V	E	Q
Secondary structure
SS confidence
Disorder																						?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3bg2 chain A Region: 4 - 503 Aligned: 387 Modelled: 391 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:dgtp triphosphohydrolase; PDBTitle: crystal structure of deoxyguanosinetriphosphate triphosphohydrolase2 from flavobacterium sp. med217 Phyre2 PDB 2pgs chain A Region: 3 - 499 Aligned: 380 Modelled: 413 Confidence: 100.0% Identity: 36% PDB header:hydrolase Chain: A: PDB Molecule:putative deoxyguanosinetriphosphate triphosphohydrolase; PDBTitle: crystal structure of a putative deoxyguanosinetriphosphate2 triphosphohydrolase from pseudomonas syringae pv. phaseolicola 1448a Phyre2 PDB 2dqb chain B Region: 11 - 501 Aligned: 320 Modelled: 330 Confidence: 100.0% Identity: 31% PDB header:hydrolase, dna binding protein Chain: B: PDB Molecule:deoxyguanosinetriphosphate triphosphohydrolase, putative; PDBTitle: crystal structure of dntp triphosphohydrolase from thermus2 thermophilus hb8, which is homologous to dgtp triphosphohydrolase Phyre2 PDB 2hek chain A domain 1 Region: 38 - 398 Aligned: 313 Modelled: 321 Confidence: 100.0% Identity: 15% Fold: HD-domain/PDEase-like Superfamily: HD-domain/PDEase-like Family: HD domain Phyre2 PDB 2o6i chain A Region: 38 - 414 Aligned: 211 Modelled: 219 Confidence: 99.9% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:hd domain protein; PDBTitle: structure of an enterococcus faecalis hd domain phosphohydrolase Phyre2 PDB 2o6i chain A domain 1 Region: 38 - 414 Aligned: 211 Modelled: 219 Confidence: 99.9% Identity: 22% Fold: HD-domain/PDEase-like Superfamily: HD-domain/PDEase-like Family: HD domain Phyre2 PDB 3u1n chain C Region: 38 - 321 Aligned: 223 Modelled: 243 Confidence: 99.9% Identity: 21% PDB header:hydrolase Chain: C: PDB Molecule:sam domain and hd domain-containing protein 1; PDBTitle: structure of the catalytic core of human samhd1 Phyre2 PDB 2q14 chain A Region: 38 - 502 Aligned: 262 Modelled: 277 Confidence: 99.9% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:phosphohydrolase; PDBTitle: crystal structure of phosphohydrolase (bt4208) from bacteroides2 thetaiotaomicron vpi-5482 at 2.20 a resolution Phyre2 PDB 3ccg chain A Region: 66 - 136 Aligned: 52 Modelled: 52 Confidence: 97.9% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:hd superfamily hydrolase; PDBTitle: crystal structure of predicted hd superfamily hydrolase involved in2 nad metabolism (np_347894.1) from clostridium acetobutylicum at 1.503 a resolution Phyre2 PDB 3gw7 chain A Region: 61 - 138 Aligned: 59 Modelled: 59 Confidence: 97.9% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized protein yedj; PDBTitle: crystal structure of a metal-dependent phosphohydrolase2 with conserved hd domain (yedj) from escherichia coli in3 complex with nickel ions. northeast structural genomics4 consortium target er63 Phyre2 PDB 2ogi chain A Region: 66 - 120 Aligned: 36 Modelled: 36 Confidence: 97.8% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:hypothetical protein sag1661; PDBTitle: crystal structure of a putative metal dependent phosphohydrolase2 (sag1661) from streptococcus agalactiae serogroup v at 1.85 a3 resolution Phyre2 PDB 2o08 chain B Region: 66 - 120 Aligned: 36 Modelled: 36 Confidence: 97.7% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:bh1327 protein; PDBTitle: crystal structure of a putative hd superfamily hydrolase (bh1327) from2 bacillus halodurans at 1.90 a resolution Phyre2 PDB 2qgs chain A domain 1 Region: 59 - 140 Aligned: 64 Modelled: 64 Confidence: 97.5% Identity: 17% Fold: HD-domain/PDEase-like Superfamily: HD-domain/PDEase-like Family: HD domain Phyre2 PDB 2pq7 chain A domain 1 Region: 57 - 129 Aligned: 54 Modelled: 54 Confidence: 97.4% Identity: 20% Fold: HD-domain/PDEase-like Superfamily: HD-domain/PDEase-like Family: HD domain Phyre2 PDB 3b57 chain A domain 1 Region: 61 - 122 Aligned: 42 Modelled: 43 Confidence: 97.1% Identity: 19% Fold: HD-domain/PDEase-like Superfamily: HD-domain/PDEase-like Family: HD domain Phyre2 PDB 3djb chain A domain 1 Region: 59 - 140 Aligned: 63 Modelled: 63 Confidence: 97.0% Identity: 17% Fold: HD-domain/PDEase-like Superfamily: HD-domain/PDEase-like Family: HD domain Phyre2 PDB 3m1t chain A Region: 68 - 279 Aligned: 126 Modelled: 127 Confidence: 96.9% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:putative phosphohydrolase; PDBTitle: crystal structure of putative phosphohydrolase (yp_929327.1) from2 shewanella amazonensis sb2b at 1.62 a resolution Phyre2 PDB 2pjq chain A domain 1 Region: 59 - 123 Aligned: 46 Modelled: 46 Confidence: 96.7% Identity: 15% Fold: HD-domain/PDEase-like Superfamily: HD-domain/PDEase-like Family: HD domain Phyre2 PDB 3dto chain A domain 1 Region: 65 - 140 Aligned: 53 Modelled: 56 Confidence: 96.6% Identity: 19% Fold: HD-domain/PDEase-like Superfamily: HD-domain/PDEase-like Family: HD domain Phyre2 PDB 3skd chain A Region: 42 - 140 Aligned: 89 Modelled: 99 Confidence: 95.7% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein tthb187; PDBTitle: crystal structure of the thermus thermophilus cas3 hd domain in the2 presence of ni2+ Phyre2 1 c3bg2A_ 2 c2pgsA_ 3 c2dqbB_ 4 d2heka1 5 c2o6iA_ 6 d2o6ia1 7 c3u1nC_ 8 c2q14A_ 9 c3ccgA_ 10 c3gw7A_ 11 c2ogiA_ 12 c2o08B_ 13 d2qgsa1 14 d2pq7a1 15 d3b57a1 16 d3djba1 17 c3m1tA_ 18 d2pjqa1 19 d3dtoa1 20 c3skdA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3bg2A_ 100.0 32 PDB header:hydrolase Chain: A: PDB Molecule:dgtp triphosphohydrolase; PDBTitle: crystal structure of deoxyguanosinetriphosphate triphosphohydrolase2 from flavobacterium sp. med217 2 c2pgsA_ 100.0 36 PDB header:hydrolase Chain: A: PDB Molecule:putative deoxyguanosinetriphosphate triphosphohydrolase; PDBTitle: crystal structure of a putative deoxyguanosinetriphosphate2 triphosphohydrolase from pseudomonas syringae pv. phaseolicola 1448a 3 c2dqbB_ 100.0 31 PDB header:hydrolase, dna binding protein Chain: B: PDB Molecule:deoxyguanosinetriphosphate triphosphohydrolase, putative; PDBTitle: crystal structure of dntp triphosphohydrolase from thermus2 thermophilus hb8, which is homologous to dgtp triphosphohydrolase 4 d2heka1 100.0 15 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 5 c2o6iA_ 99.9 22 PDB header:hydrolase Chain: A: PDB Molecule:hd domain protein; PDBTitle: structure of an enterococcus faecalis hd domain phosphohydrolase 6 d2o6ia1 99.9 22 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 7 c3u1nC_ 99.9 21 PDB header:hydrolase Chain: C: PDB Molecule:sam domain and hd domain-containing protein 1; PDBTitle: structure of the catalytic core of human samhd1 8 c2q14A_ 99.9 24 PDB header:hydrolase Chain: A: PDB Molecule:phosphohydrolase; PDBTitle: crystal structure of phosphohydrolase (bt4208) from bacteroides2 thetaiotaomicron vpi-5482 at 2.20 a resolution 9 c3ccgA_ 97.9 29 PDB header:hydrolase Chain: A: PDB Molecule:hd superfamily hydrolase; PDBTitle: crystal structure of predicted hd superfamily hydrolase involved in2 nad metabolism (np_347894.1) from clostridium acetobutylicum at 1.503 a resolution 10 c3gw7A_ 97.9 15 PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized protein yedj; PDBTitle: crystal structure of a metal-dependent phosphohydrolase2 with conserved hd domain (yedj) from escherichia coli in3 complex with nickel ions. northeast structural genomics4 consortium target er63 11 c2ogiA_ 97.8 22 PDB header:hydrolase Chain: A: PDB Molecule:hypothetical protein sag1661; PDBTitle: crystal structure of a putative metal dependent phosphohydrolase2 (sag1661) from streptococcus agalactiae serogroup v at 1.85 a3 resolution 12 c2o08B_ 97.7 25 PDB header:hydrolase Chain: B: PDB Molecule:bh1327 protein; PDBTitle: crystal structure of a putative hd superfamily hydrolase (bh1327) from2 bacillus halodurans at 1.90 a resolution 13 d2qgsa1 97.5 17 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 14 d2pq7a1 97.4 20 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 15 d3b57a1 97.1 19 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 16 d3djba1 97.0 17 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 17 c3m1tA_ 96.9 25 PDB header:hydrolase Chain: A: PDB Molecule:putative phosphohydrolase; PDBTitle: crystal structure of putative phosphohydrolase (yp_929327.1) from2 shewanella amazonensis sb2b at 1.62 a resolution 18 d2pjqa1 96.7 15 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 19 d3dtoa1 96.6 19 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 20 c3skdA_ 95.7 20 PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein tthb187; PDBTitle: crystal structure of the thermus thermophilus cas3 hd domain in the2 presence of ni2+ 21 c2ounA_ not modelled 95.3 20 PDB header:hydrolase Chain: A: PDB Molecule:camp and camp-inhibited cgmp 3',5'-cyclic PDBTitle: crystal structure of pde10a2 in complex with amp 22 d3dy8a1 not modelled 95.1 16 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:PDEase 23 c3ecmA_ not modelled 95.1 28 PDB header:hydrolase Chain: A: PDB Molecule:high affinity camp-specific and ibmx-insensitive PDBTitle: crystal structure of the unliganded pde8a catalytic domain 24 c3i7aA_ not modelled 94.9 22 PDB header:hydrolase Chain: A: PDB Molecule:putative metal-dependent phosphohydrolase; PDBTitle: crystal structure of putative metal-dependent phosphohydrolase2 (yp_926882.1) from shewanella amazonensis sb2b at 2.06 a resolution 25 c1z1lA_ not modelled 94.9 19 PDB header:hydrolase Chain: A: PDB Molecule:cgmp-dependent 3',5'-cyclic phosphodiesterase; PDBTitle: the crystal structure of the phosphodiesterase 2a catalytic2 domain 26 c2o8hA_ not modelled 94.9 21 PDB header:hydrolase Chain: A: PDB Molecule:phosphodiesterase-10a; PDBTitle: crystal structure of the catalytic domain of rat2 phosphodiesterase 10a 27 c3qi4A_ not modelled 94.8 16 PDB header:hydrolase Chain: A: PDB Molecule:high affinity cgmp-specific 3',5'-cyclic phosphodiesterase PDBTitle: crystal structure of pde9a(q453e) in complex with ibmx 28 c2r8qA_ not modelled 94.8 19 PDB header:hydrolase Chain: A: PDB Molecule:class i phosphodiesterase pdeb1; PDBTitle: structure of lmjpdeb1 in complex with ibmx 29 c3ibjB_ not modelled 94.6 19 PDB header:hydrolase Chain: B: PDB Molecule:cgmp-dependent 3',5'-cyclic phosphodiesterase; PDBTitle: x-ray structure of pde2a 30 c1zklA_ not modelled 94.6 23 PDB header:hydrolase Chain: A: PDB Molecule:high-affinity camp-specific 3',5'-cyclic PDBTitle: multiple determinants for inhibitor selectivity of cyclic2 nucleotide phosphodiesterases 31 c3g3nA_ not modelled 94.6 23 PDB header:hydrolase Chain: A: PDB Molecule:high affinity camp-specific 3',5'-cyclic PDBTitle: pde7a catalytic domain in complex with 3-(2,6-2 difluorophenyl)-2-(methylthio)quinazolin-4(3h)-one 32 d1f0ja_ not modelled 94.5 16 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:PDEase 33 d1tbfa_ not modelled 94.5 21 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:PDEase 34 c1xozA_ not modelled 94.5 21 PDB header:hydrolase Chain: A: PDB Molecule:cgmp-specific 3',5'-cyclic phosphodiesterase; PDBTitle: catalytic domain of human phosphodiesterase 5a in complex2 with tadalafil 35 c3hc1A_ not modelled 94.4 29 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized hdod domain protein; PDBTitle: crystal structure of hdod domain protein with unknown function2 (np_953345.1) from geobacter sulfurreducens at 1.90 a resolution 36 d1y2ka1 not modelled 94.2 21 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:PDEase 37 d2h44a1 not modelled 94.2 18 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:PDEase 38 c1xotB_ not modelled 93.8 16 PDB header:hydrolase Chain: B: PDB Molecule:camp-specific 3',5'-cyclic phosphodiesterase 4b; PDBTitle: catalytic domain of human phosphodiesterase 4b in complex with2 vardenafil 39 c3bjcA_ not modelled 93.7 18 PDB header:hydrolase Chain: A: PDB Molecule:cgmp-specific 3',5'-cyclic phosphodiesterase; PDBTitle: crystal structure of the pde5a catalytic domain in complex2 with a novel inhibitor 40 c2cqzA_ not modelled 93.6 21 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:177aa long hypothetical protein; PDBTitle: crystal structure of ph0347 protein from pyrococcus horikoshii ot3 41 d1taza_ not modelled 93.5 14 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:PDEase 42 d1ynba1 not modelled 93.3 14 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 43 c3kq5A_ not modelled 93.2 7 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical cytosolic protein; PDBTitle: crystal structure of an uncharacterized protein from coxiella burnetii 44 d2paqa1 not modelled 92.5 23 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 45 c3memA_ not modelled 92.3 15 PDB header:signaling protein Chain: A: PDB Molecule:putative signal transduction protein; PDBTitle: crystal structure of a putative signal transduction protein2 (maqu_0641) from marinobacter aquaeolei vt8 at 2.25 a resolution 46 d1so2a_ not modelled 92.0 18 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:PDEase 47 c3mzoA_ not modelled 91.3 15 PDB header:hydrolase Chain: A: PDB Molecule:lin2634 protein; PDBTitle: crystal structure of a hd-domain phosphohydrolase (lin2634) from2 listeria innocua at 1.98 a resolution 48 d1vqra_ not modelled 90.8 11 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:modified HD domain 49 d1u6za1 not modelled 89.4 8 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:Ppx associated domain 50 d1xx7a_ not modelled 87.0 26 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 51 c2floA_ not modelled 84.1 8 PDB header:hydrolase Chain: A: PDB Molecule:exopolyphosphatase; PDBTitle: crystal structure of exopolyphosphatase (ppx) from e. coli o157:h7 52 c3m5fA_ not modelled 83.4 20 PDB header:hydrolase Chain: A: PDB Molecule:metal dependent phosphohydrolase; PDBTitle: structure of mj0384, a cas3 protein from methanocaldococcus jannaschii 53 c3ljvA_ not modelled 81.7 18 PDB header:transcription Chain: A: PDB Molecule:mmoq response regulator; PDBTitle: crystal structure of mmoq response regulator (fragment 29-302) from2 methylococcus capsulatus str. bath, northeast structural genomics3 consortium target mcr175m 54 c3kh1B_ not modelled 79.6 25 PDB header:hydrolase Chain: B: PDB Molecule:predicted metal-dependent phosphohydrolase; PDBTitle: crystal structure of predicted metal-dependent2 phosphohydrolase (zp_00055740.2) from magnetospirillum3 magnetotacticum ms-1 at 1.37 a resolution 55 c3hi0B_ not modelled 79.1 18 PDB header:hydrolase Chain: B: PDB Molecule:putative exopolyphosphatase; PDBTitle: crystal structure of putative exopolyphosphatase (17739545) from2 agrobacterium tumefaciens str. c58 (dupont) at 2.30 a resolution 56 d2gz4a1 not modelled 69.0 20 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 57 c2zxqA_ not modelled 60.0 38 PDB header:hydrolase Chain: A: PDB Molecule:endo-alpha-n-acetylgalactosaminidase; PDBTitle: crystal structure of endo-alpha-n-acetylgalactosaminidase2 from bifidobacterium longum (engbf) 58 c3ecqA_ not modelled 57.5 25 PDB header:hydrolase Chain: A: PDB Molecule:endo-alpha-n-acetylgalactosaminidase; PDBTitle: endo-alpha-n-acetylgalactosaminidase from streptococcus pneumoniae:2 semet structure 59 d1vj7a1 not modelled 53.5 38 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 60 c1aqjB_ not modelled 47.6 71 PDB header:methyltransferase Chain: B: PDB Molecule:adenine-n6-dna-methyltransferase taqi; PDBTitle: structure of adenine-n6-dna-methyltransferase taqi 61 d2ar0a1 not modelled 46.6 71 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:N-6 DNA Methylase-like 62 c1vj7B_ not modelled 45.6 39 PDB header:hydrolase, transferase Chain: B: PDB Molecule:bifunctional rela/spot; PDBTitle: crystal structure of the bifunctional catalytic fragment of relseq,2 the rela/spot homolog from streptococcus equisimilis. 63 d2okca1 not modelled 42.6 71 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:N-6 DNA Methylase-like 64 c1g38A_ not modelled 42.2 71 PDB header:transferase/dna Chain: A: PDB Molecule:modification methylase taqi; PDBTitle: adenine-specific methyltransferase m. taq i/dna complex 65 c3khkA_ not modelled 41.8 57 PDB header:dna binding protein Chain: A: PDB Molecule:type i restriction-modification system PDBTitle: crystal structure of type-i restriction-modification system2 methylation subunit (mm_0429) from methanosarchina mazei. 66 d2f8la1 not modelled 38.9 43 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:N-6 DNA Methylase-like 67 c3lkdB_ not modelled 36.7 43 PDB header:transferase Chain: B: PDB Molecule:type i restriction-modification system PDBTitle: crystal structure of the type i restriction-modification2 system methyltransferase subunit from streptococcus3 thermophilus, northeast structural genomics consortium4 target sur80 68 c3o5cA_ not modelled 33.1 32 PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome c551 peroxidase; PDBTitle: cytochrome c peroxidase bccp of shewanella oneidensis 69 d1eb7a2 not modelled 32.3 18 Fold:Cytochrome c Superfamily:Cytochrome c Family:Di-heme cytochrome c peroxidase 70 d1b4ub_ not modelled 30.3 14 Fold:Phosphorylase/hydrolase-like Superfamily:LigB-like Family:LigB-like 71 c3nr1A_ not modelled 29.2 16 PDB header:hydrolase Chain: A: PDB Molecule:hd domain-containing protein 3; PDBTitle: a metazoan ortholog of spot hydrolyzes ppgpp and plays a role in2 starvation responses 72 c3nqwB_ not modelled 28.7 29 PDB header:hydrolase Chain: B: PDB Molecule:cg11900; PDBTitle: a metazoan ortholog of spot hydrolyzes ppgpp and plays a role in2 starvation responses 73 d1iqca2 not modelled 25.9 29 Fold:Cytochrome c Superfamily:Cytochrome c Family:Di-heme cytochrome c peroxidase 74 c3ldgA_ not modelled 24.3 63 PDB header:transferase Chain: A: PDB Molecule:putative uncharacterized protein smu.472; PDBTitle: crystal structure of smu.472, a putative methyltransferase complexed2 with sah 75 c2c1uB_ not modelled 23.5 23 PDB header:oxidoreductase Chain: B: PDB Molecule:di-haem cytochrome c peroxidase; PDBTitle: crystal structure of the di-haem cytochrome c peroxidase2 from paracoccus pantotrophus - oxidised form 76 c1nh1A_ not modelled 23.2 27 PDB header:avirulence protein Chain: A: PDB Molecule:avirulence b protein; PDBTitle: crystal structure of the type iii effector avrb from2 pseudomonas syringae. 77 d1nh1a_ not modelled 23.2 27 Fold:Antivirulence factor Superfamily:Antivirulence factor Family:Antivirulence factor 78 c3oa8B_ not modelled 21.8 35 PDB header:heme-binding protein/heme-binding protei Chain: B: PDB Molecule:soxx; PDBTitle: diheme soxax 79 c2xzn3_ not modelled 21.5 8 PDB header:ribosome Chain: 3: PDB Molecule:rps7e; PDBTitle: crystal structure of the eukaryotic 40s ribosomal2 subunit in complex with initiation factor 1. this file3 contains the 40s subunit and initiation factor for4 molecule 2 80 c3k0bA_ not modelled 20.9 50 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:predicted n6-adenine-specific dna methylase; PDBTitle: crystal structure of a predicted n6-adenine-specific dna methylase2 from listeria monocytogenes str. 4b f2365 81 c2jqqA_ not modelled 20.6 12 PDB header:protein transport Chain: A: PDB Molecule:conserved oligomeric golgi complex subunit 2; PDBTitle: solution structure of saccharomyces cerevisiae conserved2 oligomeric golgi subunit 2 protein (cog2p) 82 d1nmla2 not modelled 17.8 21 Fold:Cytochrome c Superfamily:Cytochrome c Family:Di-heme cytochrome c peroxidase 83 c3lduA_ not modelled 17.3 63 PDB header:transferase Chain: A: PDB Molecule:putative methylase; PDBTitle: the crystal structure of a possible methylase from2 clostridium difficile 630. 84 c1iqcB_ not modelled 17.3 21 PDB header:oxidoreductase Chain: B: PDB Molecule:di-heme peroxidase; PDBTitle: crystal structure of di-heme peroxidase from nitrosomonas europaea 85 c2kviA_ not modelled 17.2 13 PDB header:rna binding protein Chain: A: PDB Molecule:nuclear polyadenylated rna-binding protein 3; PDBTitle: structure of nab3 rrm 86 c2vhdB_ not modelled 16.4 18 PDB header:oxidoreductase Chain: B: PDB Molecule:cytochrome c551 peroxidase; PDBTitle: crystal structure of the di-haem cytochrome c peroxidase2 from pseudomonas aeruginosa - mixed valence form 87 c3p04B_ not modelled 16.3 25 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized bcr; PDBTitle: crystal structure of the bcr protein from corynebacterium glutamicum.2 northeast structural genomics consortium target cgr8 88 c3p04A_ not modelled 16.1 25 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized bcr; PDBTitle: crystal structure of the bcr protein from corynebacterium glutamicum.2 northeast structural genomics consortium target cgr8 89 c3zrgB_ not modelled 15.8 55 PDB header:protein binding Chain: B: PDB Molecule:pexrd2 family secreted rxlr effector peptide, putative; PDBTitle: crystal structure of rxlr effector pexrd2 from phytophthora infestans 90 c1ni3A_ not modelled 15.5 25 PDB header:hydrolase Chain: A: PDB Molecule:ychf gtp-binding protein; PDBTitle: structure of the schizosaccharomyces pombe ychf gtpase 91 d1wf2a_ not modelled 15.2 13 Fold:Ferredoxin-like Superfamily:RNA-binding domain, RBD Family:Canonical RBD 92 c2huoA_ not modelled 14.7 33 PDB header:oxidoreductase Chain: A: PDB Molecule:inositol oxygenase; PDBTitle: crystal structure of mouse myo-inositol oxygenase in complex with2 substrate 93 d3bxda1 not modelled 14.7 33 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:MioX-like 94 d2ibna1 not modelled 14.1 33 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:MioX-like 95 d1lghb_ not modelled 13.5 22 Fold:Light-harvesting complex subunits Superfamily:Light-harvesting complex subunits Family:Light-harvesting complex subunits 96 c1nmlA_ not modelled 13.2 21 PDB header:oxidoreductase Chain: A: PDB Molecule:di-haem cytochrome c peroxidase; PDBTitle: di-haemic cytochrome c peroxidase from pseudomonas nautica 617, form2 in (ph 4.0) 97 d2ovra1 not modelled 13.1 25 Fold:Skp1 dimerisation domain-like Superfamily:Skp1 dimerisation domain-like Family:Skp1 dimerisation domain-like 98 c3k6jA_ not modelled 13.1 12 PDB header:oxidoreductase Chain: A: PDB Molecule:protein f01g10.3, confirmed by transcript evidence; PDBTitle: crystal structure of the dehydrogenase part of multifuctional enzyme 12 from c.elegans 99 c3s1sA_ not modelled 12.5 43 PDB header:hydrolase, transferase Chain: A: PDB Molecule:restriction endonuclease bpusi; PDBTitle: characterization and crystal structure of the type iig restriction2 endonuclease bpusi

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0