Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	S	V	D	I	L	V	P	D	L	P	E	S	V	A	D	A	T	V	A	T	W	H	K	K	P	G	D	A	V	V	R	D	E	V	L	V	E	I	E	T	D	K	V	V	L	E	V	P	A	S	A	D	G	I	L	D	A	V
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	E	D	E	G	T	T	V	T	S	R	Q	I	L	G	R	L	R	E	G	N	S	A	G	K	E	T	S	A	K	S	E	E	K	A	S	T	P	A	Q	R	Q	Q	A	S	L	E	E	Q	N	N	D	A	L	S	P	A	I	R	R
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	L	A	E	H	N	L	D	A	S	A	I	K	G	T	G	V	G	G	R	L	T	R	E	D	V	E	K	H	L	A	K	A	P	A	K	E	S	A	P	A	A	A	A	P	A	A	Q	P	A	L	A	A	R	S	E	K	R	V	P
Secondary structure
SS confidence
Disorder													?	?	?	?		?														?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		M	T	R	L	R	K	R	V	A	E	R	L	L	E	A	K	N	S	T	A	M	L	T	T	F	N	E	V	N	M	K	P	I	M	D	L	R	K	Q	Y	G	E	A	F	E	K	R	H	G	I	R	L	G	F	M	S	F	Y	V	K
Secondary structure
SS confidence
Disorder																																													?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	V	V	E	A	L	K	R	Y	P	E	V	N	A	S	I	D	G	D	D	V	V	Y	H	N	Y	F	D	V	S	M	A	V	S	T	P	R	G	L	V	T	P	V	L	R	D	V	D	T	L	G	M	A	D	I	E	K	K	I	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		E	L	A	V	K	G	R	D	G	K	L	T	V	E	D	L	T	G	G	N	F	T	I	T	N	G	G	V	F	G	S	L	M	S	T	P	I	I	N	P	P	Q	S	A	I	L	G	M	H	A	I	K	D	R	P	M	A	V	N	G
Secondary structure
SS confidence
Disorder									?	?	?	?	?				?	?	?											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.
Sequence		Q	V	E	I	L	P	M	M	Y	L	A	L	S	Y	D	H	R	L	I	D	G	R	E	S	V	G	F	L	V	T	I	K	E	L	L	E	D	P	T	R	L	L	L	D	V
Secondary structure
SS confidence
Disorder																																												?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1b5s chain A Region: 163 - 403 Aligned: 240 Modelled: 241 Confidence: 100.0% Identity: 36% Fold: CoA-dependent acyltransferases Superfamily: CoA-dependent acyltransferases Family: CAT-like Phyre2 PDB 1dpb chain A Region: 163 - 403 Aligned: 240 Modelled: 241 Confidence: 100.0% Identity: 30% Fold: CoA-dependent acyltransferases Superfamily: CoA-dependent acyltransferases Family: CAT-like Phyre2 PDB 2ii4 chain C Region: 174 - 405 Aligned: 230 Modelled: 232 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: C: PDB Molecule:lipoamide acyltransferase component of branched-chain PDBTitle: crystal structure of a cubic core of the dihydrolipoamide2 acyltransferase (e2b) component in the branched-chain alpha-ketoacid3 dehydrogenase complex (bckdc), coenzyme a-bound form Phyre2 PDB 3l60 chain A Region: 177 - 405 Aligned: 224 Modelled: 229 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: A: PDB Molecule:branched-chain alpha-keto acid dehydrogenase; PDBTitle: crystal structure of branched-chain alpha-keto acid2 dehydrogenase subunit e2 from mycobacterium tuberculosis Phyre2 PDB 1scz chain A Region: 173 - 405 Aligned: 233 Modelled: 233 Confidence: 100.0% Identity: 100% Fold: CoA-dependent acyltransferases Superfamily: CoA-dependent acyltransferases Family: CAT-like Phyre2 PDB 3b8k chain A Region: 166 - 403 Aligned: 236 Modelled: 236 Confidence: 100.0% Identity: 31% PDB header:transferase Chain: A: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase; PDBTitle: structure of the truncated human dihydrolipoyl2 acetyltransferase (e2) Phyre2 PDB 3mae chain A Region: 173 - 400 Aligned: 228 Modelled: 228 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: A: PDB Molecule:2-oxoisovalerate dehydrogenase e2 component, PDBTitle: crystal structure of probable dihydrolipamide2 acetyltransferase from listeria monocytogenes 4b f2365 Phyre2 PDB 3rqc chain B Region: 175 - 402 Aligned: 215 Modelled: 228 Confidence: 100.0% Identity: 36% PDB header:transferase Chain: B: PDB Molecule:probable lipoamide acyltransferase; PDBTitle: crystal structure of the catalytic core of the 2-oxoacid dehydrogenase2 multienzyme complex from thermoplasma acidophilum Phyre2 PDB 1q23 chain A Region: 175 - 398 Aligned: 205 Modelled: 224 Confidence: 100.0% Identity: 8% Fold: CoA-dependent acyltransferases Superfamily: CoA-dependent acyltransferases Family: CAT-like Phyre2 PDB 3cla chain A Region: 195 - 400 Aligned: 188 Modelled: 206 Confidence: 100.0% Identity: 10% Fold: CoA-dependent acyltransferases Superfamily: CoA-dependent acyltransferases Family: CAT-like Phyre2 PDB 2i9d chain C Region: 172 - 396 Aligned: 189 Modelled: 225 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: C: PDB Molecule:chloramphenicol acetyltransferase; PDBTitle: chloramphenicol acetyltransferase Phyre2 PDB 2dne chain A Region: 3 - 102 Aligned: 100 Modelled: 100 Confidence: 99.9% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase PDBTitle: solution structure of rsgi ruh-058, a lipoyl domain of2 human 2-oxoacid dehydrogenase Phyre2 PDB 2dnc chain A Region: 1 - 92 Aligned: 91 Modelled: 92 Confidence: 99.9% Identity: 34% PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase protein x component; PDBTitle: solution structure of rsgi ruh-054, a lipoyl domain from2 human 2-oxoacid dehydrogenase Phyre2 PDB 1y8o chain B domain 1 Region: 4 - 92 Aligned: 89 Modelled: 89 Confidence: 99.9% Identity: 28% Fold: Barrel-sandwich hybrid Superfamily: Single hybrid motif Family: Biotinyl/lipoyl-carrier proteins and domains Phyre2 PDB 2q8i chain B Region: 2 - 88 Aligned: 87 Modelled: 87 Confidence: 99.9% Identity: 29% PDB header:transferase Chain: B: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase component of PDBTitle: pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug2 radicicol Phyre2 PDB 1k8m chain A Region: 1 - 86 Aligned: 86 Modelled: 86 Confidence: 99.8% Identity: 22% Fold: Barrel-sandwich hybrid Superfamily: Single hybrid motif Family: Biotinyl/lipoyl-carrier proteins and domains Phyre2 PDB 2l5t chain A Region: 4 - 79 Aligned: 76 Modelled: 76 Confidence: 99.8% Identity: 32% PDB header:transferase Chain: A: PDB Molecule:lipoamide acyltransferase; PDBTitle: solution nmr structure of e2 lipoyl domain from thermoplasma2 acidophilum Phyre2 PDB 1ghj chain A Region: 4 - 81 Aligned: 78 Modelled: 78 Confidence: 99.8% Identity: 60% Fold: Barrel-sandwich hybrid Superfamily: Single hybrid motif Family: Biotinyl/lipoyl-carrier proteins and domains Phyre2 PDB 1gjx chain A Region: 2 - 83 Aligned: 81 Modelled: 82 Confidence: 99.8% Identity: 23% Fold: Barrel-sandwich hybrid Superfamily: Single hybrid motif Family: Biotinyl/lipoyl-carrier proteins and domains Phyre2 PDB 1qjo chain A Region: 1 - 83 Aligned: 80 Modelled: 82 Confidence: 99.8% Identity: 26% Fold: Barrel-sandwich hybrid Superfamily: Single hybrid motif Family: Biotinyl/lipoyl-carrier proteins and domains Phyre2 PDB 2coo chain A Region: 98 - 166 Aligned: 69 Modelled: 69 Confidence: 99.2% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:lipoamide acyltransferase component of branched- PDBTitle: solution structure of the e3_binding domain of2 dihydrolipoamide branched chaintransacylase Phyre2 PDB 1bal chain A Region: 104 - 153 Aligned: 50 Modelled: 50 Confidence: 99.1% Identity: 100% Fold: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Superfamily: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Family: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Phyre2 PDB 1w4h chain A domain 1 Region: 109 - 153 Aligned: 45 Modelled: 45 Confidence: 99.1% Identity: 100% Fold: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Superfamily: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Family: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Phyre2 PDB 2cyu chain A domain 1 Region: 114 - 152 Aligned: 39 Modelled: 39 Confidence: 99.0% Identity: 100% Fold: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Superfamily: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Family: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Phyre2 1 d1b5sa_ 2 d1dpba_ 3 c2ii4C_ 4 c3l60A_ 5 d1scza_ 6 c3b8kA_ 7 c3maeA_ 8 c3rqcB_ 9 d1q23a_ 10 d3claa_ 11 c2i9dC_ 12 c2dneA_ 13 c2dncA_ 14 d1y8ob1 15 c2q8iB_ 16 d1k8ma_ 17 c2l5tA_ 18 d1ghja_ 19 d1gjxa_ 20 d1qjoa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 c2cooA_ 36 d1bala_ 37 38 39 40 d1w4ha1 41 42 43 44 d2cyua1 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1b5sa_ 100.0 36 Fold:CoA-dependent acyltransferases Superfamily:CoA-dependent acyltransferases Family:CAT-like 2 d1dpba_ 100.0 30 Fold:CoA-dependent acyltransferases Superfamily:CoA-dependent acyltransferases Family:CAT-like 3 c2ii4C_ 100.0 30 PDB header:transferase Chain: C: PDB Molecule:lipoamide acyltransferase component of branched-chain PDBTitle: crystal structure of a cubic core of the dihydrolipoamide2 acyltransferase (e2b) component in the branched-chain alpha-ketoacid3 dehydrogenase complex (bckdc), coenzyme a-bound form 4 c3l60A_ 100.0 29 PDB header:oxidoreductase Chain: A: PDB Molecule:branched-chain alpha-keto acid dehydrogenase; PDBTitle: crystal structure of branched-chain alpha-keto acid2 dehydrogenase subunit e2 from mycobacterium tuberculosis 5 d1scza_ 100.0 100 Fold:CoA-dependent acyltransferases Superfamily:CoA-dependent acyltransferases Family:CAT-like 6 c3b8kA_ 100.0 31 PDB header:transferase Chain: A: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase; PDBTitle: structure of the truncated human dihydrolipoyl2 acetyltransferase (e2) 7 c3maeA_ 100.0 34 PDB header:transferase Chain: A: PDB Molecule:2-oxoisovalerate dehydrogenase e2 component, PDBTitle: crystal structure of probable dihydrolipamide2 acetyltransferase from listeria monocytogenes 4b f2365 8 c3rqcB_ 100.0 36 PDB header:transferase Chain: B: PDB Molecule:probable lipoamide acyltransferase; PDBTitle: crystal structure of the catalytic core of the 2-oxoacid dehydrogenase2 multienzyme complex from thermoplasma acidophilum 9 d1q23a_ 100.0 8 Fold:CoA-dependent acyltransferases Superfamily:CoA-dependent acyltransferases Family:CAT-like 10 d3claa_ 100.0 10 Fold:CoA-dependent acyltransferases Superfamily:CoA-dependent acyltransferases Family:CAT-like 11 c2i9dC_ 100.0 18 PDB header:transferase Chain: C: PDB Molecule:chloramphenicol acetyltransferase; PDBTitle: chloramphenicol acetyltransferase 12 c2dneA_ 99.9 20 PDB header:transferase Chain: A: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase PDBTitle: solution structure of rsgi ruh-058, a lipoyl domain of2 human 2-oxoacid dehydrogenase 13 c2dncA_ 99.9 34 PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase protein x component; PDBTitle: solution structure of rsgi ruh-054, a lipoyl domain from2 human 2-oxoacid dehydrogenase 14 d1y8ob1 99.9 28 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 15 c2q8iB_ 99.9 29 PDB header:transferase Chain: B: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase component of PDBTitle: pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug2 radicicol 16 d1k8ma_ 99.8 22 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 17 c2l5tA_ 99.8 32 PDB header:transferase Chain: A: PDB Molecule:lipoamide acyltransferase; PDBTitle: solution nmr structure of e2 lipoyl domain from thermoplasma2 acidophilum 18 d1ghja_ 99.8 60 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 19 d1gjxa_ 99.8 23 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 20 d1qjoa_ 99.8 26 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 21 d1laba_ not modelled 99.8 35 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 22 d1pmra_ not modelled 99.8 100 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 23 d1iyua_ not modelled 99.8 28 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 24 c2xt6B_ not modelled 99.7 28 PDB header:lyase Chain: B: PDB Molecule:2-oxoglutarate decarboxylase; PDBTitle: crystal structure of mycobacterium smegmatis alpha-ketoglutarate2 decarboxylase homodimer (orthorhombic form) 25 d2pnrc1 not modelled 99.7 36 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 26 c2ejmA_ not modelled 99.7 19 PDB header:ligase Chain: A: PDB Molecule:methylcrotonoyl-coa carboxylase subunit alpha; PDBTitle: solution structure of ruh-072, an apo-biotnyl domain form2 human acetyl coenzyme a carboxylase 27 c2dn8A_ not modelled 99.7 16 PDB header:ligase Chain: A: PDB Molecule:acetyl-coa carboxylase 2; PDBTitle: solution structure of rsgi ruh-053, an apo-biotin carboxy2 carrier protein from human transcarboxylase 28 c2kccA_ not modelled 99.6 14 PDB header:ligase Chain: A: PDB Molecule:acetyl-coa carboxylase 2; PDBTitle: solution structure of biotinoyl domain from human acetyl-2 coa carboxylase 2 29 c2b8gA_ not modelled 99.6 23 PDB header:biosynthetic protein Chain: A: PDB Molecule:biotin/lipoyl attachment protein; PDBTitle: solution structure of bacillus subtilis blap biotinylated-2 form (energy minimized mean structure) 30 d1dcza_ not modelled 99.5 30 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 31 c2ejgD_ not modelled 99.5 30 PDB header:ligase Chain: D: PDB Molecule:149aa long hypothetical methylmalonyl-coa decarboxylase PDBTitle: crystal structure of the biotin protein ligase (mutation r48a) and2 biotin carboxyl carrier protein complex from pyrococcus horikoshii3 ot3 32 d1o78a_ not modelled 99.4 30 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 33 c3n6rK_ not modelled 99.4 15 PDB header:ligase Chain: K: PDB Molecule:propionyl-coa carboxylase, alpha subunit; PDBTitle: crystal structure of the holoenzyme of propionyl-coa carboxylase (pcc) 34 d1bdoa_ not modelled 99.4 23 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 35 c2cooA_ 99.2 25 PDB header:transferase Chain: A: PDB Molecule:lipoamide acyltransferase component of branched- PDBTitle: solution structure of the e3_binding domain of2 dihydrolipoamide branched chaintransacylase 36 d1bala_ 99.1 100 Fold:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Superfamily:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Family:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 37 c1zwvA_ not modelled 99.1 32 PDB header:transferase Chain: A: PDB Molecule:lipoamide acyltransferase component of branched- PDBTitle: solution structure of the subunit binding domain (hbsbd) of2 the human mitochondrial branched-chain alpha-ketoacid3 dehydrogenase 38 c1w4kA_ not modelled 99.1 40 PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase e2; PDBTitle: peripheral-subunit binding domains from mesophilic,2 thermophilic, and hyperthermophilic bacteria fold by3 ultrafast, apparently two-state transitions 39 c1w3dA_ not modelled 99.1 29 PDB header:transferase Chain: A: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase PDBTitle: nmr structure of the peripheral-subunit binding domain of2 bacillus stearothermophilus e2p 40 d1w4ha1 99.1 100 Fold:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Superfamily:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Family:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 41 c3dv0I_ not modelled 99.1 32 PDB header:oxidoreductase/transferase Chain: I: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase PDBTitle: snapshots of catalysis in the e1 subunit of the pyruvate2 dehydrogenase multi-enzyme complex 42 c2eq9C_ not modelled 99.0 30 PDB header:oxidoreductase Chain: C: PDB Molecule:pyruvate dehydrogenase complex, dihydrolipoamide PDBTitle: crystal structure of lipoamide dehydrogenase from thermus thermophilus2 hb8 with psbdb 43 d1w85i_ not modelled 99.0 32 Fold:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Superfamily:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Family:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 44 d2cyua1 99.0 100 Fold:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Superfamily:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Family:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 45 c2eq7C_ not modelled 98.9 41 PDB header:oxidoreductase Chain: C: PDB Molecule:2-oxoglutarate dehydrogenase e2 component; PDBTitle: crystal structure of lipoamide dehydrogenase from thermus thermophilus2 hb8 with psbdo 46 c2eq8C_ not modelled 98.9 42 PDB header:oxidoreductase Chain: C: PDB Molecule:pyruvate dehydrogenase complex, dihydrolipoamide PDBTitle: crystal structure of lipoamide dehydrogenase from thermus thermophilus2 hb8 with psbdp 47 c2qf7A_ not modelled 98.5 16 PDB header:ligase Chain: A: PDB Molecule:pyruvate carboxylase protein; PDBTitle: crystal structure of a complete multifunctional pyruvate carboxylase2 from rhizobium etli 48 c2k33A_ not modelled 98.1 25 PDB header:membrane protein, transport protein Chain: A: PDB Molecule:acra; PDBTitle: solution structure of an n-glycosylated protein using in2 vitro glycosylation 49 c3h9iB_ not modelled 97.5 23 PDB header:transport protein Chain: B: PDB Molecule:cation efflux system protein cusb; PDBTitle: crystal structure of the membrane fusion protein cusb from escherichia2 coli 50 d1onla_ not modelled 97.4 22 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 51 c2edgA_ not modelled 97.3 19 PDB header:biosynthetic protein Chain: A: PDB Molecule:glycine cleavage system h protein; PDBTitle: solution structure of the gcv_h domain from mouse glycine 52 d1hpca_ not modelled 97.3 22 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 53 c3iftA_ not modelled 97.3 30 PDB header:oxidoreductase Chain: A: PDB Molecule:glycine cleavage system h protein; PDBTitle: crystal structure of glycine cleavage system protein h from2 mycobacterium tuberculosis, using x-rays from the compact light3 source. 54 c3mxuA_ not modelled 97.3 19 PDB header:oxidoreductase Chain: A: PDB Molecule:glycine cleavage system h protein; PDBTitle: crystal structure of glycine cleavage system protein h from bartonella2 henselae 55 c2f5zK_ not modelled 97.1 46 PDB header:oxidoreductase/protein binding Chain: K: PDB Molecule:pyruvate dehydrogenase protein x component; PDBTitle: crystal structure of human dihydrolipoamide dehydrogenase2 (e3) complexed to the e3-binding domain of human e3-3 binding protein 56 c1zy8M_ not modelled 97.1 42 PDB header:oxidoreductase Chain: M: PDB Molecule:pyruvate dehydrogenase protein x component, PDBTitle: the crystal structure of dihydrolipoamide dehydrogenase and2 dihydrolipoamide dehydrogenase-binding protein (didomain)3 subcomplex of human pyruvate dehydrogenase complex. 57 c2ka7A_ not modelled 96.9 30 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:glycine cleavage system h protein; PDBTitle: nmr solution structure of tm0212 at 40 c 58 c3a8jF_ not modelled 96.9 19 PDB header:transferase/transport protein Chain: F: PDB Molecule:glycine cleavage system h protein; PDBTitle: crystal structure of et-ehred complex 59 c2qj8B_ not modelled 96.8 11 PDB header:hydrolase Chain: B: PDB Molecule:mlr6093 protein; PDBTitle: crystal structure of an aspartoacylase family protein (mlr6093) from2 mesorhizobium loti maff303099 at 2.00 a resolution 60 c3fmcC_ not modelled 96.5 17 PDB header:hydrolase Chain: C: PDB Molecule:putative succinylglutamate desuccinylase / aspartoacylase; PDBTitle: crystal structure of a putative succinylglutamate desuccinylase /2 aspartoacylase family protein (sama_0604) from shewanella amazonensis3 sb2b at 1.80 a resolution 61 c3na6A_ not modelled 96.4 14 PDB header:hydrolase Chain: A: PDB Molecule:succinylglutamate desuccinylase/aspartoacylase; PDBTitle: crystal structure of a succinylglutamate desuccinylase (tm1040_2694)2 from silicibacter sp. tm1040 at 2.00 a resolution 62 c2aukA_ not modelled 96.3 35 PDB header:transferase Chain: A: PDB Molecule:dna-directed rna polymerase beta' chain; PDBTitle: structure of e. coli rna polymerase beta' g/g' insert 63 c1t5eB_ not modelled 95.9 29 PDB header:transport protein Chain: B: PDB Molecule:multidrug resistance protein mexa; PDBTitle: the structure of mexa 64 c3fppB_ not modelled 95.8 23 PDB header:membrane protein Chain: B: PDB Molecule:macrolide-specific efflux protein maca; PDBTitle: crystal structure of e.coli maca 65 d1vf7a_ not modelled 95.7 29 Fold:HlyD-like secretion proteins Superfamily:HlyD-like secretion proteins Family:HlyD-like secretion proteins 66 c3cdxB_ not modelled 95.7 21 PDB header:hydrolase Chain: B: PDB Molecule:succinylglutamatedesuccinylase/aspartoacylase; PDBTitle: crystal structure of2 succinylglutamatedesuccinylase/aspartoacylase from3 rhodobacter sphaeroides 67 c3lnnB_ not modelled 95.2 15 PDB header:metal transport Chain: B: PDB Molecule:membrane fusion protein (mfp) heavy metal cation efflux PDBTitle: crystal structure of zneb from cupriavidus metallidurans 68 c2f1mA_ not modelled 95.1 21 PDB header:transport protein Chain: A: PDB Molecule:acriflavine resistance protein a; PDBTitle: conformational flexibility in the multidrug efflux system protein acra 69 d2gpra_ not modelled 94.1 13 Fold:Barrel-sandwich hybrid Superfamily:Duplicated hybrid motif Family:Glucose permease-like 70 d1brwa3 not modelled 93.1 38 Fold:alpha/beta-Hammerhead Superfamily:Pyrimidine nucleoside phosphorylase C-terminal domain Family:Pyrimidine nucleoside phosphorylase C-terminal domain 71 c2jkuA_ not modelled 93.1 38 PDB header:ligase Chain: A: PDB Molecule:propionyl-coa carboxylase alpha chain, PDBTitle: crystal structure of the n-terminal region of the biotin2 acceptor domain of human propionyl-coa carboxylase 72 c2aujD_ not modelled 92.8 23 PDB header:transferase Chain: D: PDB Molecule:dna-directed rna polymerase beta' chain; PDBTitle: structure of thermus aquaticus rna polymerase beta'-subunit2 insert 73 c3d4rE_ not modelled 91.6 17 PDB header:unknown function Chain: E: PDB Molecule:domain of unknown function from the pfam-b_34464 family; PDBTitle: crystal structure of a duf2118 family protein (mmp0046) from2 methanococcus maripaludis at 2.20 a resolution 74 d1glaf_ not modelled 91.5 21 Fold:Barrel-sandwich hybrid Superfamily:Duplicated hybrid motif Family:Glucose permease-like 75 d1gpra_ not modelled 90.4 21 Fold:Barrel-sandwich hybrid Superfamily:Duplicated hybrid motif Family:Glucose permease-like 76 d2f3ga_ not modelled 90.2 12 Fold:Barrel-sandwich hybrid Superfamily:Duplicated hybrid motif Family:Glucose permease-like 77 d2tpta3 not modelled 90.0 25 Fold:alpha/beta-Hammerhead Superfamily:Pyrimidine nucleoside phosphorylase C-terminal domain Family:Pyrimidine nucleoside phosphorylase C-terminal domain 78 c3h5qA_ not modelled 90.0 33 PDB header:transferase Chain: A: PDB Molecule:pyrimidine-nucleoside phosphorylase; PDBTitle: crystal structure of a putative pyrimidine-nucleoside phosphorylase2 from staphylococcus aureus 79 d1o4ua2 not modelled 90.0 24 Fold:alpha/beta-Hammerhead Superfamily:Nicotinate/Quinolinate PRTase N-terminal domain-like Family:NadC N-terminal domain-like 80 d1uoua3 not modelled 89.8 17 Fold:alpha/beta-Hammerhead Superfamily:Pyrimidine nucleoside phosphorylase C-terminal domain Family:Pyrimidine nucleoside phosphorylase C-terminal domain 81 c2dsjA_ not modelled 89.6 38 PDB header:transferase Chain: A: PDB Molecule:pyrimidine-nucleoside (thymidine) phosphorylase; PDBTitle: crystal structure of project id tt0128 from thermus thermophilus hb8 82 c1brwB_ not modelled 89.4 38 PDB header:transferase Chain: B: PDB Molecule:protein (pyrimidine nucleoside phosphorylase); PDBTitle: the crystal structure of pyrimidine nucleoside2 phosphorylase in a closed conformation 83 c2j0fC_ not modelled 88.8 17 PDB header:transferase Chain: C: PDB Molecule:thymidine phosphorylase; PDBTitle: structural basis for non-competitive product inhibition in2 human thymidine phosphorylase: implication for drug design 84 d1qapa2 not modelled 88.2 33 Fold:alpha/beta-Hammerhead Superfamily:Nicotinate/Quinolinate PRTase N-terminal domain-like Family:NadC N-terminal domain-like 85 c1otpA_ not modelled 86.8 25 PDB header:phosphorylase Chain: A: PDB Molecule:thymidine phosphorylase; PDBTitle: structural and theoretical studies suggest domain movement produces an2 active conformation of thymidine phosphorylase 86 d1qpoa2 not modelled 86.8 24 Fold:alpha/beta-Hammerhead Superfamily:Nicotinate/Quinolinate PRTase N-terminal domain-like Family:NadC N-terminal domain-like 87 c3gnnA_ not modelled 86.4 24 PDB header:transferase Chain: A: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: crystal structure of nicotinate-nucleotide2 pyrophosphorylase from burkholderi pseudomallei 88 c3pajA_ not modelled 85.4 24 PDB header:transferase Chain: A: PDB Molecule:nicotinate-nucleotide pyrophosphorylase, carboxylating; PDBTitle: 2.00 angstrom resolution crystal structure of a quinolinate2 phosphoribosyltransferase from vibrio cholerae o1 biovar eltor str.3 n16961 89 c1o4uA_ not modelled 84.1 24 PDB header:transferase Chain: A: PDB Molecule:type ii quinolic acid phosphoribosyltransferase; PDBTitle: crystal structure of a nicotinate nucleotide pyrophosphorylase2 (tm1645) from thermotoga maritima at 2.50 a resolution 90 c2jbmA_ not modelled 83.9 19 PDB header:transferase Chain: A: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: qprtase structure from human 91 c1qpoA_ not modelled 83.2 24 PDB header:transferase Chain: A: PDB Molecule:quinolinate acid phosphoribosyl transferase; PDBTitle: quinolinate phosphoribosyl transferase (qaprtase) apo-enzyme from2 mycobacterium tuberculosis 92 c1qapA_ not modelled 82.7 33 PDB header:glycosyltransferase Chain: A: PDB Molecule:quinolinic acid phosphoribosyltransferase; PDBTitle: quinolinic acid phosphoribosyltransferase with bound2 quinolinic acid 93 c3tqvA_ not modelled 82.5 19 PDB header:transferase Chain: A: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: structure of the nicotinate-nucleotide pyrophosphorylase from2 francisella tularensis. 94 c3l0gD_ not modelled 82.4 38 PDB header:transferase Chain: D: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: crystal structure of nicotinate-nucleotide pyrophosphorylase from2 ehrlichia chaffeensis at 2.05a resolution 95 c2b7pA_ not modelled 81.6 19 PDB header:transferase Chain: A: PDB Molecule:probable nicotinate-nucleotide pyrophosphorylase; PDBTitle: crystal structure of quinolinic acid phosphoribosyltransferase from2 helicobacter pylori 96 c1x1oC_ not modelled 81.1 14 PDB header:transferase Chain: C: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: crystal structure of project id tt0268 from thermus thermophilus hb8 97 c2zbaD_ not modelled 79.4 11 PDB header:transferase Chain: D: PDB Molecule:trichothecene 3-o-acetyltransferase; PDBTitle: crystal sructure of f. sporotrichioides tri101 complexed with coenzyme2 a and t-2 98 c2jgpA_ not modelled 78.6 14 PDB header:ligase Chain: A: PDB Molecule:tyrocidine synthetase 3; PDBTitle: structure of the tycc5-6 pcp-c bidomain of the tyrocidine2 synthetase tycc 99 c2gu1A_ not modelled 77.6 15 PDB header:hydrolase Chain: A: PDB Molecule:zinc peptidase; PDBTitle: crystal structure of a zinc containing peptidase from2 vibrio cholerae 100 d1e2wa2 not modelled 72.6 31 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:Cytochrome f, small domain 101 c2e1uA_ not modelled 72.3 18 PDB header:transferase Chain: A: PDB Molecule:acyl transferase; PDBTitle: crystal structure of dendranthema morifolium dmat 102 c2vsqA_ not modelled 70.9 11 PDB header:ligase Chain: A: PDB Molecule:surfactin synthetase subunit 3; PDBTitle: structure of surfactin a synthetase c (srfa-c), a2 nonribosomal peptide synthetase termination module 103 d1ci3m2 not modelled 68.8 22 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:Cytochrome f, small domain 104 c2hsiB_ not modelled 65.4 19 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative peptidase m23; PDBTitle: crystal structure of putative peptidase m23 from2 pseudomonas aeruginosa, new york structural genomics3 consortium 105 c2bghA_ not modelled 60.7 14 PDB header:transferase Chain: A: PDB Molecule:vinorine synthase; PDBTitle: crystal structure of vinorine synthase 106 d1qwya_ not modelled 59.6 6 Fold:Barrel-sandwich hybrid Superfamily:Duplicated hybrid motif Family:Peptidoglycan hydrolase LytM 107 c2xr7A_ not modelled 58.6 21 PDB header:transferase Chain: A: PDB Molecule:malonyltransferase; PDBTitle: crystal structure of nicotiana tabacum malonyltransferase (ntmat1)2 complexed with malonyl-coa 108 c3c2vA_ not modelled 55.6 24 PDB header:transferase Chain: A: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: crystal structure of the quinolinate phosphoribosyl2 transferase (bna6) from saccharomyces cerevisiae complexed3 with prpp and the inhibitor phthalate 109 c2b44A_ not modelled 54.4 13 PDB header:hydrolase Chain: A: PDB Molecule:glycyl-glycine endopeptidase lytm; PDBTitle: truncated s. aureus lytm, p 32 2 1 crystal form 110 c1e2vB_ not modelled 52.8 31 PDB header:electron transport proteins Chain: B: PDB Molecule:cytochrome f; PDBTitle: n153q mutant of cytochrome f from chlamydomonas reinhardtii 111 c1tu2B_ not modelled 47.5 25 PDB header:electron transport Chain: B: PDB Molecule:apocytochrome f; PDBTitle: the complex of nostoc cytochrome f and plastocyanin determin with2 paramagnetic nmr. based on the structures of cytochrome f and3 plastocyanin, 10 structures 112 c1q90A_ not modelled 46.9 31 PDB header:photosynthesis Chain: A: PDB Molecule:apocytochrome f; PDBTitle: structure of the cytochrome b6f (plastohydroquinone : plastocyanin2 oxidoreductase) from chlamydomonas reinhardtii 113 c2xhaB_ not modelled 46.8 24 PDB header:transcription Chain: B: PDB Molecule:transcription antitermination protein nusg; PDBTitle: crystal structure of domain 2 of thermotoga maritima n-utilization2 substance g (nusg) 114 d1hcza2 not modelled 43.9 19 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:Cytochrome f, small domain 115 c3fotA_ not modelled 43.5 15 PDB header:transferase Chain: A: PDB Molecule:15-o-acetyltransferase; PDBTitle: structural and functional characterization of tri3 trichothecene 15-o-2 acetyltransferase from fusarium sporotrichioides 116 c2e75C_ not modelled 42.5 31 PDB header:photosynthesis Chain: C: PDB Molecule:apocytochrome f; PDBTitle: crystal structure of the cytochrome b6f complex with 2-nonyl-4-2 hydroxyquinoline n-oxide (nqno) from m.laminosus 117 c2xhgA_ not modelled 42.2 14 PDB header:isomerase Chain: A: PDB Molecule:tyrocidine synthetase a; PDBTitle: crystal structure of the epimerization domain from the initiation2 module of tyrocidine biosynthesis 118 d1tu2b2 not modelled 40.8 25 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:Cytochrome f, small domain 119 c3it5B_ not modelled 40.4 19 PDB header:hydrolase Chain: B: PDB Molecule:protease lasa; PDBTitle: crystal structure of the lasa virulence factor from pseudomonas2 aeruginosa 120 c3nyyA_ not modelled 38.3 25 PDB header:hydrolase Chain: A: PDB Molecule:putative glycyl-glycine endopeptidase lytm; PDBTitle: crystal structure of a putative glycyl-glycine endopeptidase lytm2 (rumgna_02482) from ruminococcus gnavus atcc 29149 at 1.60 a3 resolution

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0