Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP07813
DateThu Jan 5 11:00:33 GMT 2012
Unique Job ID3d31a6648420c6b0

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c1qu2A_
Top template information
PDB header:ligase/rna
Chain: A: PDB Molecule:isoleucyl-trna synthetase;
PDBTitle: insights into editing from an ile-trna synthetase structure2 with trna(ile) and mupirocin
Confidence and coverage
Confidence:100.0% Coverage: 83%
714 residues ( 83% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
782 residues ( 91%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGD
Secondary structure 
SS confidence 
Disorder  ??????
?
?????
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  VIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYD
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  WSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCD
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  TKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYD
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  NTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAAFIDECRNTKVAEAEMATMEK
Secondary structure 
SS confidence 
Disorder 
?
????
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  KGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVI
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  LAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKVNYRLRDW
Secondary structure 
SS confidence 
Disorder 
??
?
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  GVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPEDVVMDGITSPIKADPEWAKTTVNG
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  MPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSEAANYWLPVDIYIGGIEHAIMHLLY
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........550.........560.........570.........580.........590.........600
Sequence  FRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGR
Secondary structure 
SS confidence 
Disorder 
?????
??????
???
?
??
Disorder confidence 
 
   .........610.........620.........630.........640.........650.........660
Sequence  IVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQE
Secondary structure 
SS confidence 
Disorder 
??????????????????
Disorder confidence 
 
   .........670.........680.........690.........700.........710.........720
Sequence  SGVEGANRFLKRVWKLVYEHTAKGDVAALNVDALTENQKALRRDVHKTIAKVTDDIGRRQ
Secondary structure 
SS confidence 
Disorder 
???
??
Disorder confidence 
 
   .........730.........740.........750.........760.........770.........780
Sequence  TFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEG
Secondary structure 
SS confidence 
Disorder 
?
Disorder confidence 
 
   .........790.........800.........810.........820.........830.........840
Sequence  DIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLD
Secondary structure 
SS confidence 
Disorder  ?
??
?
Disorder confidence 
 
   .........850.........860
Sequence  GVTVRKVIYVPGKLLNLVVG
Secondary structure 
SS confidence 
Disorder 
??
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1qu2 chain A

3D model

Region: 2 - 819
Aligned: 714
Modelled: 732
Confidence: 100.0%
Identity: 22%
PDB header:ligase/rna
Chain: A: PDB Molecule:isoleucyl-trna synthetase;
PDBTitle: insights into editing from an ile-trna synthetase structure2 with trna(ile) and mupirocin

Phyre2

PDB 1obh chain A

3D model

Region: 3 - 797
Aligned: 747
Modelled: 759
Confidence: 100.0%
Identity: 43%
PDB header:synthetase
Chain: A: PDB Molecule:leucyl-trna synthetase;
PDBTitle: leucyl-trna synthetase from thermus thermophilus complexed2 with a pre-transfer editing substrate analogue in both3 synthetic active site and editing site

Phyre2

PDB 1gax chain B

3D model

Region: 1 - 821
Aligned: 665
Modelled: 679
Confidence: 100.0%
Identity: 26%
PDB header:ligase/rna
Chain: B: PDB Molecule:valyl-trna synthetase;
PDBTitle: crystal structure of thermus thermophilus valyl-trna2 synthetase complexed with trna(val) and valyl-adenylate3 analogue

Phyre2

PDB 1ile chain A

3D model

Region: 3 - 816
Aligned: 712
Modelled: 724
Confidence: 100.0%
Identity: 24%
PDB header:aminoacyl-trna synthetase
Chain: A: PDB Molecule:isoleucyl-trna synthetase;
PDBTitle: isoleucyl-trna synthetase

Phyre2

PDB 1wz2 chain B

3D model

Region: 6 - 817
Aligned: 701
Modelled: 713
Confidence: 100.0%
Identity: 27%
PDB header:ligase/rna
Chain: B: PDB Molecule:leucyl-trna synthetase;
PDBTitle: the crystal structure of leucyl-trna synthetase and trna(leucine)2 complex

Phyre2

PDB 1wkb chain A

3D model

Region: 6 - 777
Aligned: 663
Modelled: 674
Confidence: 100.0%
Identity: 26%
PDB header:ligase
Chain: A: PDB Molecule:leucyl-trna synthetase;
PDBTitle: crystal structure of leucyl-trna synthetase from the2 archaeon pyrococcus horikoshii reveals a novel editing3 domain orientation

Phyre2

PDB 1h3n chain A domain 3

3D model

Region: 1 - 668
Aligned: 470
Modelled: 478
Confidence: 100.0%
Identity: 54%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2

PDB 1rqg chain A

3D model

Region: 33 - 830
Aligned: 513
Modelled: 518
Confidence: 100.0%
Identity: 24%
PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: methionyl-trna synthetase from pyrococcus abyssi

Phyre2

PDB 1ffy chain A domain 3

3D model

Region: 1 - 668
Aligned: 417
Modelled: 435
Confidence: 100.0%
Identity: 28%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2

PDB 1ile chain A domain 3

3D model

Region: 4 - 668
Aligned: 422
Modelled: 433
Confidence: 100.0%
Identity: 29%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2

PDB 1pfu chain A

3D model

Region: 32 - 809
Aligned: 484
Modelled: 504
Confidence: 100.0%
Identity: 22%
PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: methionyl-trna synthetase from escherichia coli complexed2 with methionine phosphinate

Phyre2

PDB 3kfl chain A

3D model

Region: 32 - 788
Aligned: 466
Modelled: 481
Confidence: 100.0%
Identity: 23%
PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: leishmania major methionyl-trna synthetase in complex with2 methionyladenylate and pyrophosphate

Phyre2

PDB 1woy chain A

3D model

Region: 32 - 798
Aligned: 470
Modelled: 497
Confidence: 100.0%
Identity: 23%
PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: crystal structure of methionyl trna synthetase y225f mutant2 from thermus thermophilus

Phyre2

PDB 1ivs chain A domain 4

3D model

Region: 1 - 669
Aligned: 407
Modelled: 421
Confidence: 100.0%
Identity: 32%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2

PDB 2ct8 chain A

3D model

Region: 33 - 797
Aligned: 432
Modelled: 463
Confidence: 100.0%
Identity: 28%
PDB header:ligase/rna
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: crystal structure of aquifex aeolicus methionyl-trna2 synthetase complexed with trna(met) and methionyl-adenylate3 anologue

Phyre2

PDB 2x1l chain C

3D model

Region: 33 - 781
Aligned: 422
Modelled: 437
Confidence: 100.0%
Identity: 28%
PDB header:ligase
Chain: C: PDB Molecule:methionyl-trna synthetase;
PDBTitle: crystal structure of mycobacterium smegmatis methionyl-trna2 synthetase in complex with methionine and adenosine

Phyre2

PDB 1rqg chain A domain 2

3D model

Region: 33 - 668
Aligned: 346
Modelled: 366
Confidence: 100.0%
Identity: 25%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2

PDB 2d5b chain A domain 2

3D model

Region: 32 - 668
Aligned: 342
Modelled: 357
Confidence: 100.0%
Identity: 26%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2

PDB 1pfv chain A domain 2

3D model

Region: 32 - 672
Aligned: 342
Modelled: 367
Confidence: 100.0%
Identity: 24%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Nucleotidylyl transferase
Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain

Phyre2

PDB 1u0b chain B

3D model

Region: 25 - 781
Aligned: 394
Modelled: 401
Confidence: 100.0%
Identity: 23%
PDB header:ligase/rna
Chain: B: PDB Molecule:cysteinyl trna;
PDBTitle: crystal structure of cysteinyl-trna synthetase binary2 complex with trnacys

Phyre2

PDB 1rqg chain A domain 1

3D model

Region: 667 - 829
Aligned: 162
Modelled: 162
Confidence: 99.7%
Identity: 16%
Fold: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases

Phyre2
1
c1qu2A_
2
c1obhA_
3
c1gaxB_
4
c1ileA_
5
c1wz2B_
6
c1wkbA_
7
d1h3na3
8
c1rqgA_
9
d1ffya3
10
d1ilea3
11
c1pfuA_
12
c3kflA_
13
c1woyA_
14
d1ivsa4
15
c2ct8A_
16
c2x1lC_
17
d1rqga2
18
d2d5ba2
19
d1pfva2
20
c1u0bB_
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
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41
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d1rqga1
47
48
49
50
51
52
53
54
55
56
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c1qu2A_
100.0 22 PDB header:ligase/rna
Chain: A: PDB Molecule:isoleucyl-trna synthetase;
PDBTitle: insights into editing from an ile-trna synthetase structure2 with trna(ile) and mupirocin
2c1obhA_
100.0 43 PDB header:synthetase
Chain: A: PDB Molecule:leucyl-trna synthetase;
PDBTitle: leucyl-trna synthetase from thermus thermophilus complexed2 with a pre-transfer editing substrate analogue in both3 synthetic active site and editing site
3c1gaxB_
100.0 26 PDB header:ligase/rna
Chain: B: PDB Molecule:valyl-trna synthetase;
PDBTitle: crystal structure of thermus thermophilus valyl-trna2 synthetase complexed with trna(val) and valyl-adenylate3 analogue
4c1ileA_
100.0 24 PDB header:aminoacyl-trna synthetase
Chain: A: PDB Molecule:isoleucyl-trna synthetase;
PDBTitle: isoleucyl-trna synthetase
5c1wz2B_
100.0 27 PDB header:ligase/rna
Chain: B: PDB Molecule:leucyl-trna synthetase;
PDBTitle: the crystal structure of leucyl-trna synthetase and trna(leucine)2 complex
6c1wkbA_
100.0 26 PDB header:ligase
Chain: A: PDB Molecule:leucyl-trna synthetase;
PDBTitle: crystal structure of leucyl-trna synthetase from the2 archaeon pyrococcus horikoshii reveals a novel editing3 domain orientation
7d1h3na3
100.0 54 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
8c1rqgA_
100.0 24 PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: methionyl-trna synthetase from pyrococcus abyssi
9d1ffya3
100.0 28 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
10d1ilea3
100.0 29 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
11c1pfuA_
100.0 22 PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: methionyl-trna synthetase from escherichia coli complexed2 with methionine phosphinate
12c3kflA_
100.0 23 PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: leishmania major methionyl-trna synthetase in complex with2 methionyladenylate and pyrophosphate
13c1woyA_
100.0 23 PDB header:ligase
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: crystal structure of methionyl trna synthetase y225f mutant2 from thermus thermophilus
14d1ivsa4
100.0 32 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
15c2ct8A_
100.0 28 PDB header:ligase/rna
Chain: A: PDB Molecule:methionyl-trna synthetase;
PDBTitle: crystal structure of aquifex aeolicus methionyl-trna2 synthetase complexed with trna(met) and methionyl-adenylate3 anologue
16c2x1lC_
100.0 28 PDB header:ligase
Chain: C: PDB Molecule:methionyl-trna synthetase;
PDBTitle: crystal structure of mycobacterium smegmatis methionyl-trna2 synthetase in complex with methionine and adenosine
17d1rqga2
100.0 25 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
18d2d5ba2
100.0 26 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
19d1pfva2
100.0 24 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
20c1u0bB_
100.0 23 PDB header:ligase/rna
Chain: B: PDB Molecule:cysteinyl trna;
PDBTitle: crystal structure of cysteinyl-trna synthetase binary2 complex with trnacys
21c3tqoA_
not modelled 100.0 22 PDB header:ligase
Chain: A: PDB Molecule:cysteinyl-trna synthetase;
PDBTitle: structure of the cysteinyl-trna synthetase (cyss) from coxiella2 burnetii.
22c3c8zB_
not modelled 100.0 26 PDB header:ligase
Chain: B: PDB Molecule:cysteinyl-trna synthetase;
PDBTitle: the 1.6 a crystal structure of mshc: the rate limiting2 enzyme in the mycothiol biosynthetic pathway
23c2ajhA_
not modelled 100.0 99 PDB header:ligase
Chain: A: PDB Molecule:leucyl-trna synthetase;
PDBTitle: crystal structure of the editing domain of e. coli leucyl-2 trna synthetase complexes with methionine
24d1h3na2
not modelled 100.0 44 Fold:ValRS/IleRS/LeuRS editing domain
Superfamily:ValRS/IleRS/LeuRS editing domain
Family:ValRS/IleRS/LeuRS editing domain
25c3sp1B_
not modelled 100.0 19 PDB header:ligase
Chain: B: PDB Molecule:cysteinyl-trna synthetase;
PDBTitle: crystal structure of cysteinyl-trna synthetase (cyss) from borrelia2 burgdorferi
26c3o0aB_
not modelled 100.0 42 PDB header:ligase
Chain: B: PDB Molecule:leucyl-trna synthetase subunit alpha;
PDBTitle: crystal structure of the wild type cp1 hydrolitic domain from aquifex2 aeolicus leucyl-trna
27c2wfdB_
not modelled 100.0 21 PDB header:ligase
Chain: B: PDB Molecule:leucyl-trna synthetase, cytoplasmic;
PDBTitle: structure of the human cytosolic leucyl-trna synthetase2 editing domain
28d1li5a2
not modelled 100.0 27 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
29c3fnrA_
not modelled 100.0 24 PDB header:transferase
Chain: A: PDB Molecule:arginyl-trna synthetase;
PDBTitle: crystal structure of putative arginyl t-rna synthetase from2 campylobacter jejuni;
30d1udza_
not modelled 100.0 23 Fold:ValRS/IleRS/LeuRS editing domain
Superfamily:ValRS/IleRS/LeuRS editing domain
Family:ValRS/IleRS/LeuRS editing domain
31c1iq0A_
not modelled 100.0 22 PDB header:ligase
Chain: A: PDB Molecule:arginyl-trna synthetase;
PDBTitle: thermus thermophilus arginyl-trna synthetase
32c3pz6F_
not modelled 100.0 22 PDB header:ligase
Chain: F: PDB Molecule:leucyl-trna synthetase;
PDBTitle: the crystal structure of glleurs-cp1
33d1wkaa1
not modelled 100.0 27 Fold:ValRS/IleRS/LeuRS editing domain
Superfamily:ValRS/IleRS/LeuRS editing domain
Family:ValRS/IleRS/LeuRS editing domain
34c2wfgA_
not modelled 100.0 19 PDB header:ligase
Chain: A: PDB Molecule:cytosolic leucyl-trna synthetase;
PDBTitle: structure of the candida albicans cytosolic leucyl-trna2 synthetase editing domain bound to a benzoxaborole-amp3 adduct
35d1ffya2
not modelled 100.0 26 Fold:ValRS/IleRS/LeuRS editing domain
Superfamily:ValRS/IleRS/LeuRS editing domain
Family:ValRS/IleRS/LeuRS editing domain
36d1iq0a2
not modelled 99.9 23 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
37d1ivsa2
not modelled 99.9 14 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
38d1ilea1
not modelled 99.9 26 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
39d1qu3a1
not modelled 99.9 16 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
40c2zufA_
not modelled 99.9 24 PDB header:ligase/rna
Chain: A: PDB Molecule:arginyl-trna synthetase;
PDBTitle: crystal structure of pyrococcus horikoshii arginyl-trna2 synthetase complexed with trna(arg)
41d1h3na1
not modelled 99.9 34 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
42d1ffya1
not modelled 99.9 15 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
43d1f7ua2
not modelled 99.9 22 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
44d1irxa2
not modelled 99.8 22 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
45c1f7uA_
not modelled 99.7 24 PDB header:ligase/rna
Chain: A: PDB Molecule:arginyl-trna synthetase;
PDBTitle: crystal structure of the arginyl-trna synthetase complexed with the2 trna(arg) and l-arg
46d1rqga1
99.7 16 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
47c1g59A_
not modelled 99.5 25 PDB header:ligase/rna
Chain: A: PDB Molecule:glutamyl-trna synthetase;
PDBTitle: glutamyl-trna synthetase complexed with trna(glu).
48d1pfva1
not modelled 99.3 15 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
49c3afhA_
not modelled 99.3 17 PDB header:ligase
Chain: A: PDB Molecule:glutamyl-trna synthetase 2;
PDBTitle: crystal structure of thermotoga maritima nondiscriminating glutamyl-2 trna synthetase in complex with a glutamyl-amp analog
50c2cfoA_
not modelled 99.3 23 PDB header:ligase
Chain: A: PDB Molecule:glutamyl-trna synthetase;
PDBTitle: non-discriminating glutamyl-trna synthetase from2 thermosynechococcus elongatus in complex with glu
51c2ja2A_
not modelled 99.3 25 PDB header:ligase
Chain: A: PDB Molecule:glutamyl-trna synthetase;
PDBTitle: mycobacterium tuberculosis glutamyl-trna synthetase
52d2d5ba1
not modelled 99.3 13 Fold:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Superfamily:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
Family:Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
53c2o5rA_
not modelled 99.2 23 PDB header:ligase
Chain: A: PDB Molecule:glutamyl-trna synthetase 1;
PDBTitle: crystal structure of glutamyl-trna synthetase 1 (ec 6.1.1.17)2 (glutamate-trna ligase 1) (glurs 1) (tm1351) from thermotoga maritima3 at 2.5 a resolution
54c1irxA_
not modelled 98.6 20 PDB header:ligase
Chain: A: PDB Molecule:lysyl-trna synthetase;
PDBTitle: crystal structure of class i lysyl-trna synthetase
55d1gtra2
not modelled 98.5 29 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
56c3aiiA_
not modelled 98.4 26 PDB header:ligase
Chain: A: PDB Molecule:glutamyl-trna synthetase;
PDBTitle: archaeal non-discriminating glutamyl-trna synthetase from2 methanothermobacter thermautotrophicus
57d1nzja_
not modelled 98.4 25 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
58c2hz7A_
not modelled 98.4 27 PDB header:ligase
Chain: A: PDB Molecule:glutaminyl-trna synthetase;
PDBTitle: crystal structure of the glutaminyl-trna synthetase from2 deinococcus radiodurans
59c1exdA_
not modelled 98.3 30 PDB header:ligase/rna
Chain: A: PDB Molecule:glutaminyl-trna synthetase;
PDBTitle: crystal structure of a tight-binding glutamine trna bound2 to glutamine aminoacyl trna synthetase
60d1j09a2
not modelled 98.1 25 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
61c3al0C_
not modelled 98.0 22 PDB header:ligase/rna
Chain: C: PDB Molecule:glutamyl-trna(gln) amidotransferase subunit c, glutamyl-
PDBTitle: crystal structure of the glutamine transamidosome from thermotoga2 maritima in the glutamylation state.
62c1h3eA_
not modelled 96.9 28 PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: tyrosyl-trna synthetase from thermus thermophilus complexed2 with wild-type trnatyr(gua) and with atp and tyrosinol
63c3prhB_
not modelled 96.9 20 PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: tryptophanyl-trna synthetase val144pro mutant from b. subtilis
64c2cybA_
not modelled 96.6 21 PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: crystal structure of tyrosyl-trna synthetase complexed with2 l-tyrosine from archaeoglobus fulgidus
65d1h3fa1
not modelled 96.6 25 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
66c2el7A_
not modelled 96.3 25 PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from thermus2 thermophilus
67c3focB_
not modelled 96.1 20 PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: tryptophanyl-trna synthetase from giardia lamblia
68c3a05A_
not modelled 96.1 17 PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from2 hyperthermophilic archaeon, aeropyrum pernix k1 complex3 with tryptophan
69c2janD_
not modelled 96.0 24 PDB header:ligase
Chain: D: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: tyrosyl-trna synthetase from mycobacterium tuberculosis in2 unliganded state
70c3jxeB_
not modelled 95.9 18 PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of pyrococcus horikoshii tryptophanyl-trna2 synthetase in complex with trpamp
71c1jiiA_
not modelled 95.9 23 PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: crystal structure of s. aureus tyrrs in complex with sb-219383
72c2rkjM_
not modelled 95.8 21 PDB header:ligase/rna
Chain: M: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: cocrystal structure of a tyrosyl-trna synthetase splicing2 factor with a group i intron rna
73c1x8xA_
not modelled 95.7 19 PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: tyrosyl t-rna synthetase from e.coli complexed with tyrosine
74c2dlcX_
not modelled 95.7 13 PDB header:ligase/trna
Chain: X: PDB Molecule:tyrosyl-trna synthetase, cytoplasmic;
PDBTitle: crystal structure of the ternary complex of yeast tyrosyl-trna2 synthetase
75d1jila_
not modelled 95.6 21 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
76d1i6la_
not modelled 95.4 12 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
77c2g36A_
not modelled 95.4 13 PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase (ec 6.1.1.2)2 (tryptophan-trna ligase)(trprs) (tm0492) from thermotoga maritima at3 2.50 a resolution
78d1j1ua_
not modelled 95.3 17 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
79c2pidB_
not modelled 95.1 19 PDB header:ligase
Chain: B: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: crystal structure of human mitochondrial tyrosyl-trna synthetase in2 complex with an adenylate analog
80c2j5bA_
not modelled 95.0 15 PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: structure of the tyrosyl trna synthetase from acanthamoeba2 polyphaga mimivirus complexed with tyrosynol
81c3hv0A_
not modelled 94.9 17 PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: tryptophanyl-trna synthetase from cryptosporidium parvum
82c2cyaA_
not modelled 94.7 11 PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: crystal structure of tyrosyl-trna synthetase from aeropyrum pernix
83c3m5wB_
not modelled 94.6 13 PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from2 campylobacter jejuni
84c2cycB_
not modelled 94.5 19 PDB header:ligase
Chain: B: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: crystal structure of tyrosyl-trna synthetase complexed with l-tyrosine2 from pyrococcus horikoshii
85c1yi8C_
not modelled 94.4 16 PDB header:ligase
Chain: C: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl trrna synthetase ii from deinococcus2 radiodurans in complex with l-trp
86c3i05B_
not modelled 94.2 14 PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: tryptophanyl-trna synthetase from trypanosoma brucei
87c3hzrD_
not modelled 94.2 16 PDB header:ligase
Chain: D: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: tryptophanyl-trna synthetase homolog from entamoeba histolytica
88c3p0jD_
not modelled 94.1 17 PDB header:ligase
Chain: D: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: leishmania major tyrosyl-trna synthetase in complex with tyrosinol,2 triclinic crystal form 1
89c2ip1A_
not modelled 94.0 11 PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure analysis of s. cerevisiae tryptophanyl trna2 synthetase
90c2quiB_
not modelled 93.9 15 PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structures of human tryptophanyl-trna synthetase in2 complex with tryptophanamide and atp
91c2yy5C_
not modelled 93.6 23 PDB header:ligase
Chain: C: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from mycoplasma2 pneumoniae
92d1n3la_
not modelled 93.6 10 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
93d2ts1a_
not modelled 93.4 15 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
94c2ts1A_
not modelled 93.4 15 PDB header:ligase (synthetase)
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: structure of tyrosyl-t/rna synthetase refined at 2.3 angstroms2 resolution. interaction of the enzyme with the tyrosyl adenylate3 intermediate
95c3sz3A_
not modelled 93.0 12 PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from vibrio cholerae2 with an endogenous tryptophan
96c1q11A_
not modelled 92.2 11 PDB header:ligase
Chain: A: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: crystal structure of an active fragment of human tyrosyl-trna2 synthetase with tyrosinol
97c1r6uB_
not modelled 92.2 16 PDB header:ligase
Chain: B: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of an active fragment of human tryptophanyl-trna2 synthetase with cytokine activity
98c3n9iA_
not modelled 92.1 14 PDB header:ligase
Chain: A: PDB Molecule:tryptophanyl-trna synthetase;
PDBTitle: crystal structure of tryptophanyl-trna synthetase from yersinia pestis2 co92
99d1r6ta2
not modelled 90.0 16 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain
100c1qoyA_
not modelled 44.7 8 PDB header:toxin
Chain: A: PDB Molecule:hemolysin e;
PDBTitle: e.coli hemolysin e (hlye, clya, shea)
101c1yuzB_
not modelled 40.9 22 PDB header:oxidoreductase
Chain: B: PDB Molecule:nigerythrin;
PDBTitle: partially reduced state of nigerythrin
102c2opfA_
not modelled 39.6 27 PDB header:hydrolase/dna
Chain: A: PDB Molecule:endonuclease viii;
PDBTitle: crystal structure of the dna repair enzyme endonuclease-viii (nei)2 from e. coli (r252a) in complex with ap-site containing dna substrate
103c1nnjA_
not modelled 37.5 20 PDB header:hydrolase
Chain: A: PDB Molecule:formamidopyrimidine-dna glycosylase;
PDBTitle: crystal structure complex between the lactococcus lactis fpg and an2 abasic site containing dna
104c1k82D_
not modelled 37.4 20 PDB header:hydrolase/dna
Chain: D: PDB Molecule:formamidopyrimidine-dna glycosylase;
PDBTitle: crystal structure of e.coli formamidopyrimidine-dna2 glycosylase (fpg) covalently trapped with dna
105c1ee8A_
not modelled 34.9 19 PDB header:dna binding protein
Chain: A: PDB Molecule:mutm (fpg) protein;
PDBTitle: crystal structure of mutm (fpg) protein from thermus thermophilus hb8
106c2f5qA_
not modelled 34.9 20 PDB header:hydrolase/dna
Chain: A: PDB Molecule:formamidopyrimidine-dna glycosidase;
PDBTitle: catalytically inactive (e3q) mutm crosslinked to oxog:c2 containing dna cc2
107d1l8ya_
not modelled 33.4 31 Fold:HMG-box
Superfamily:HMG-box
Family:HMG-box
108d1k3xa3
not modelled 29.0 27 Fold:Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:Glucocorticoid receptor-like (DNA-binding domain)
Family:C-terminal, Zn-finger domain of MutM-like DNA repair proteins
109c3a46B_
not modelled 24.7 25 PDB header:hydrolase
Chain: B: PDB Molecule:formamidopyrimidine-dna glycosylase;
PDBTitle: crystal structure of mvnei1/thf complex
110d2cqqa1
not modelled 24.4 21 Fold:DNA/RNA-binding 3-helical bundle
Superfamily:Homeodomain-like
Family:Myb/SANT domain
111c3i86A_
not modelled 23.2 39 PDB header:hydrolase
Chain: A: PDB Molecule:putative uncharacterized protein;
PDBTitle: crystal structure of the p60 domain from m. avium subspecies2 paratuberculosis antigen map1204
112d1ee8a3
not modelled 23.1 19 Fold:Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:Glucocorticoid receptor-like (DNA-binding domain)
Family:C-terminal, Zn-finger domain of MutM-like DNA repair proteins
113d1r2za3
not modelled 22.9 20 Fold:Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:Glucocorticoid receptor-like (DNA-binding domain)
Family:C-terminal, Zn-finger domain of MutM-like DNA repair proteins
114c2kdxA_
not modelled 22.3 20 PDB header:metal-binding protein
Chain: A: PDB Molecule:hydrogenase/urease nickel incorporation protein
PDBTitle: solution structure of hypa protein
115d1tdza3
not modelled 21.9 20 Fold:Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:Glucocorticoid receptor-like (DNA-binding domain)
Family:C-terminal, Zn-finger domain of MutM-like DNA repair proteins
116c2hr5B_
not modelled 21.2 22 PDB header:metal binding protein
Chain: B: PDB Molecule:rubrerythrin;
PDBTitle: pf1283- rubrerythrin from pyrococcus furiosus iron bound form
117c2k53A_
not modelled 21.1 17 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:a3dk08 protein;
PDBTitle: nmr solution structure of a3dk08 protein from clostridium2 thermocellum: northeast structural genomics consortium3 target cmr9

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0