Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	F	K	V	I	A	L	A	A	L	M	G	I	S	G	M	A	A	Q	A	N	E	L	P	D	G	P	H	I	V	T	S	G	T	A	S	V	D	A	V	P	D	I	A	T	L	A	I	E	V	N	V	A	A	K	D	A	A	T
Secondary structure
SS confidence
Disorder		?	?														?	?	?	?	?	?	?	?	?	?	?	?																													?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	K	K	Q	A	D	E	R	V	A	Q	Y	I	S	F	L	E	L	N	Q	I	A	K	K	D	I	S	S	A	N	L	R	T	Q	P	D	Y	D	Y	Q	D	G	K	S	I	L	K	G	Y	R	A	V	R	T	V	E	V	T	L	R
Secondary structure
SS confidence
Disorder																														?									?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Q	L	D	K	L	N	S	L	L	D	G	A	L	K	A	G	L	N	E	I	R	S	V	S	L	G	V	A	Q	P	D	A	Y	K	D	K	A	R	K	A	A	I	D	N	A	I	H	Q	A	Q	E	L	A	N	G	F	H	R	K	L
Secondary structure
SS confidence
Disorder																?	?	?	?	?		?																																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	P	V	Y	S	V	R	Y	H	V	S	N	Y	Q	P	S	P	M	V	R	M	M	K	A	D	A	A	P	V	S	A	Q	E	T	Y	E	Q	A	A	I	Q	F	D	D	Q	V	D	V	V	F	Q	L	E	P	V	D	Q	Q	P	A
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.
Sequence		K	T	P	A	A	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3cyq chain M Region: 62 - 131 Aligned: 70 Modelled: 70 Confidence: 29.1% Identity: 19% PDB header:membrane protein Chain: M: PDB Molecule:chemotaxis protein motb; PDBTitle: the crystal structure of the complex of the c-terminal domain of2 helicobacter pylori motb (residues 125-256) with n-acetylmuramic acid Phyre2 PDB 3tqu chain D Region: 114 - 190 Aligned: 69 Modelled: 77 Confidence: 26.4% Identity: 14% PDB header:hydrolase Chain: D: PDB Molecule:non-canonical purine ntp pyrophosphatase; PDBTitle: structure of a ham1 protein from coxiella burnetii Phyre2 PDB 2cz4 chain A domain 1 Region: 68 - 145 Aligned: 71 Modelled: 78 Confidence: 23.0% Identity: 7% Fold: Ferredoxin-like Superfamily: GlnB-like Family: Prokaryotic signal transducing protein Phyre2 PDB 1nye chain D Region: 3 - 71 Aligned: 69 Modelled: 69 Confidence: 22.4% Identity: 23% Fold: OsmC-like Superfamily: OsmC-like Family: Ohr/OsmC resistance proteins Phyre2 PDB 2onf chain A domain 1 Region: 3 - 71 Aligned: 69 Modelled: 69 Confidence: 21.7% Identity: 10% Fold: OsmC-like Superfamily: OsmC-like Family: Ohr/OsmC resistance proteins Phyre2 PDB 1u6r chain A domain 2 Region: 47 - 138 Aligned: 84 Modelled: 92 Confidence: 20.7% Identity: 11% Fold: Glutamine synthetase/guanido kinase Superfamily: Glutamine synthetase/guanido kinase Family: Guanido kinase catalytic domain Phyre2 PDB 1muw chain A Region: 123 - 241 Aligned: 113 Modelled: 119 Confidence: 20.6% Identity: 15% Fold: TIM beta/alpha-barrel Superfamily: Xylose isomerase-like Family: Xylose isomerase Phyre2 PDB 1a0e chain A Region: 155 - 241 Aligned: 81 Modelled: 87 Confidence: 20.5% Identity: 14% Fold: TIM beta/alpha-barrel Superfamily: Xylose isomerase-like Family: Xylose isomerase Phyre2 PDB 1crk chain A domain 2 Region: 47 - 136 Aligned: 82 Modelled: 90 Confidence: 20.4% Identity: 9% Fold: Glutamine synthetase/guanido kinase Superfamily: Glutamine synthetase/guanido kinase Family: Guanido kinase catalytic domain Phyre2 PDB 3qtd chain C Region: 62 - 171 Aligned: 89 Modelled: 90 Confidence: 19.9% Identity: 21% PDB header:gene regulation Chain: C: PDB Molecule:pmba protein; PDBTitle: crystal structure of putative modulator of gyrase (pmba) from2 pseudomonas aeruginosa pao1 Phyre2 PDB 2rrl chain A Region: 37 - 104 Aligned: 63 Modelled: 68 Confidence: 19.2% Identity: 10% PDB header:protein transport Chain: A: PDB Molecule:flagellar hook-length control protein; PDBTitle: solution structure of the c-terminal domain of the flik Phyre2 PDB 1qk1 chain A domain 2 Region: 47 - 136 Aligned: 82 Modelled: 90 Confidence: 18.9% Identity: 7% Fold: Glutamine synthetase/guanido kinase Superfamily: Glutamine synthetase/guanido kinase Family: Guanido kinase catalytic domain Phyre2 PDB 1b78 chain A Region: 114 - 190 Aligned: 66 Modelled: 77 Confidence: 18.2% Identity: 12% Fold: Anticodon-binding domain-like Superfamily: ITPase-like Family: ITPase (Ham1) Phyre2 PDB 1vrp chain A domain 2 Region: 47 - 136 Aligned: 82 Modelled: 82 Confidence: 18.1% Identity: 9% Fold: Glutamine synthetase/guanido kinase Superfamily: Glutamine synthetase/guanido kinase Family: Guanido kinase catalytic domain Phyre2 PDB 1k7k chain A Region: 109 - 190 Aligned: 74 Modelled: 82 Confidence: 17.8% Identity: 19% Fold: Anticodon-binding domain-like Superfamily: ITPase-like Family: ITPase (Ham1) Phyre2 PDB 1qh4 chain A domain 2 Region: 47 - 136 Aligned: 82 Modelled: 90 Confidence: 17.8% Identity: 11% Fold: Glutamine synthetase/guanido kinase Superfamily: Glutamine synthetase/guanido kinase Family: Guanido kinase catalytic domain Phyre2 PDB 2x48 chain B Region: 137 - 183 Aligned: 45 Modelled: 47 Confidence: 15.8% Identity: 20% PDB header:viral protein Chain: B: PDB Molecule:cag38821; PDBTitle: orf 55 from sulfolobus islandicus rudivirus 1 Phyre2 PDB 1ukk chain A Region: 4 - 67 Aligned: 64 Modelled: 64 Confidence: 14.5% Identity: 16% Fold: OsmC-like Superfamily: OsmC-like Family: Ohr/OsmC resistance proteins Phyre2 PDB 1xlm chain A Region: 123 - 241 Aligned: 113 Modelled: 119 Confidence: 14.4% Identity: 14% Fold: TIM beta/alpha-barrel Superfamily: Xylose isomerase-like Family: Xylose isomerase Phyre2 PDB 1a0c chain A Region: 155 - 241 Aligned: 81 Modelled: 87 Confidence: 14.0% Identity: 14% Fold: TIM beta/alpha-barrel Superfamily: Xylose isomerase-like Family: Xylose isomerase Phyre2 1 c3cyqM_ 2 c3tquD_ 3 d2cz4a1 4 d1nyed_ 5 d2onfa1 6 d1u6ra2 7 d1muwa_ 8 d1a0ea_ 9 d1crka2 10 c3qtdC_ 11 c2rrlA_ 12 d1qk1a2 13 d1b78a_ 14 d1vrpa2 15 d1k7ka_ 16 d1qh4a2 17 c2x48B_ 18 d1ukka_ 19 d1xlma_ 20 d1a0ca_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3cyqM_ 29.1 19 PDB header:membrane protein Chain: M: PDB Molecule:chemotaxis protein motb; PDBTitle: the crystal structure of the complex of the c-terminal domain of2 helicobacter pylori motb (residues 125-256) with n-acetylmuramic acid 2 c3tquD_ 26.4 14 PDB header:hydrolase Chain: D: PDB Molecule:non-canonical purine ntp pyrophosphatase; PDBTitle: structure of a ham1 protein from coxiella burnetii 3 d2cz4a1 23.0 7 Fold:Ferredoxin-like Superfamily:GlnB-like Family:Prokaryotic signal transducing protein 4 d1nyed_ 22.4 23 Fold:OsmC-like Superfamily:OsmC-like Family:Ohr/OsmC resistance proteins 5 d2onfa1 21.7 10 Fold:OsmC-like Superfamily:OsmC-like Family:Ohr/OsmC resistance proteins 6 d1u6ra2 20.7 11 Fold:Glutamine synthetase/guanido kinase Superfamily:Glutamine synthetase/guanido kinase Family:Guanido kinase catalytic domain 7 d1muwa_ 20.6 15 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase 8 d1a0ea_ 20.5 14 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase 9 d1crka2 20.4 9 Fold:Glutamine synthetase/guanido kinase Superfamily:Glutamine synthetase/guanido kinase Family:Guanido kinase catalytic domain 10 c3qtdC_ 19.9 21 PDB header:gene regulation Chain: C: PDB Molecule:pmba protein; PDBTitle: crystal structure of putative modulator of gyrase (pmba) from2 pseudomonas aeruginosa pao1 11 c2rrlA_ 19.2 10 PDB header:protein transport Chain: A: PDB Molecule:flagellar hook-length control protein; PDBTitle: solution structure of the c-terminal domain of the flik 12 d1qk1a2 18.9 7 Fold:Glutamine synthetase/guanido kinase Superfamily:Glutamine synthetase/guanido kinase Family:Guanido kinase catalytic domain 13 d1b78a_ 18.2 12 Fold:Anticodon-binding domain-like Superfamily:ITPase-like Family:ITPase (Ham1) 14 d1vrpa2 18.1 9 Fold:Glutamine synthetase/guanido kinase Superfamily:Glutamine synthetase/guanido kinase Family:Guanido kinase catalytic domain 15 d1k7ka_ 17.8 19 Fold:Anticodon-binding domain-like Superfamily:ITPase-like Family:ITPase (Ham1) 16 d1qh4a2 17.8 11 Fold:Glutamine synthetase/guanido kinase Superfamily:Glutamine synthetase/guanido kinase Family:Guanido kinase catalytic domain 17 c2x48B_ 15.8 20 PDB header:viral protein Chain: B: PDB Molecule:cag38821; PDBTitle: orf 55 from sulfolobus islandicus rudivirus 1 18 d1ukka_ 14.5 16 Fold:OsmC-like Superfamily:OsmC-like Family:Ohr/OsmC resistance proteins 19 d1xlma_ 14.4 14 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase 20 d1a0ca_ 14.0 14 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase 21 d1a0da_ not modelled 13.8 17 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase 22 c1i0eD_ not modelled 13.7 10 PDB header:transferase Chain: D: PDB Molecule:creatine kinase,m chain; PDBTitle: crystal structure of creatine kinase from human muscle 23 d2opla1 not modelled 13.4 10 Fold:OsmC-like Superfamily:OsmC-like Family:Ohr/OsmC resistance proteins 24 c2kxhB_ not modelled 13.1 24 PDB header:protein binding Chain: B: PDB Molecule:peptide of far upstream element-binding protein 1; PDBTitle: solution structure of the first two rrm domains of fir in the complex2 with fbp nbox peptide 25 d2cara1 not modelled 12.9 10 Fold:Anticodon-binding domain-like Superfamily:ITPase-like Family:ITPase (Ham1) 26 c3k1dA_ not modelled 12.6 16 PDB header:transferase Chain: A: PDB Molecule:1,4-alpha-glucan-branching enzyme; PDBTitle: crystal structure of glycogen branching enzyme synonym: 1,4-alpha-d-2 glucan:1,4-alpha-d-glucan 6-glucosyl-transferase from mycobacterium3 tuberculosis h37rv 27 d1lqla_ not modelled 12.5 14 Fold:OsmC-like Superfamily:OsmC-like Family:Ohr/OsmC resistance proteins 28 c1lqlE_ not modelled 12.5 14 PDB header:unknown function Chain: E: PDB Molecule:osmotical inducible protein c like family; PDBTitle: crystal structure of osmc like protein from mycoplasma2 pneumoniae 29 d1qt1a_ not modelled 12.3 15 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase 30 c3amlA_ not modelled 12.2 20 PDB header:transferase Chain: A: PDB Molecule:os06g0726400 protein; PDBTitle: structure of the starch branching enzyme i (bei) from oryza sativa l 31 c2zf8A_ not modelled 11.3 7 PDB header:structural protein Chain: A: PDB Molecule:component of sodium-driven polar flagellar motor; PDBTitle: crystal structure of moty 32 d1xima_ not modelled 10.7 12 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase 33 d1qwia_ not modelled 10.6 25 Fold:OsmC-like Superfamily:OsmC-like Family:Ohr/OsmC resistance proteins 34 d1h3ga3 not modelled 10.4 16 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 35 c1m7xC_ not modelled 10.0 22 PDB header:transferase Chain: C: PDB Molecule:1,4-alpha-glucan branching enzyme; PDBTitle: the x-ray crystallographic structure of branching enzyme 36 c1zb8B_ not modelled 9.6 13 PDB header:oxidoreductase Chain: B: PDB Molecule:organic hydroperoxide resistance protein; PDBTitle: crystal structure of xylella fastidiosa organic peroxide resistance2 protein 37 c1jd7A_ not modelled 9.1 12 PDB header:hydrolase Chain: A: PDB Molecule:alpha-amylase; PDBTitle: crystal structure analysis of the mutant k300r of2 pseudoalteromonas haloplanctis alpha-amylase 38 d1g0wa2 not modelled 8.7 12 Fold:Glutamine synthetase/guanido kinase Superfamily:Glutamine synthetase/guanido kinase Family:Guanido kinase catalytic domain 39 d1r3na2 not modelled 8.6 14 Fold:Ferredoxin-like Superfamily:Bacterial exopeptidase dimerisation domain Family:Bacterial exopeptidase dimerisation domain 40 d1xp8a2 not modelled 8.6 16 Fold:Anti-LPS factor/recA domain Superfamily:RecA protein, C-terminal domain Family:RecA protein, C-terminal domain 41 d1jjcb4 not modelled 8.3 12 Fold:Ferredoxin-like Superfamily:Anticodon-binding domain of PheRS Family:Anticodon-binding domain of PheRS 42 c1qk1H_ not modelled 7.6 8 PDB header:transferase (creatine kinase) Chain: H: PDB Molecule:creatine kinase, ubiquitous mitochondrial; PDBTitle: crystal structure of human ubiquitous mitochondrial2 creatine kinase 43 c1ceuA_ not modelled 7.3 31 PDB header:viral protein Chain: A: PDB Molecule:protein (hiv-1 regulatory protein n-terminal PDBTitle: nmr structure of the (1-51) n-terminal domain of the hiv-12 regulatory protein 44 c3eerA_ not modelled 7.0 9 PDB header:oxidoreductase Chain: A: PDB Molecule:organic hydroperoxide resistance protein, putative; PDBTitle: high resolution structure of putative organic hydroperoxide resistance2 protein from vibrio cholerae o1 biovar eltor str. n16961 45 c1mg1A_ not modelled 6.8 23 PDB header:viral protein Chain: A: PDB Molecule:protein (htlv-1 gp21 ectodomain/maltose-binding protein PDBTitle: htlv-1 gp21 ectodomain/maltose-binding protein chimera 46 c3l2eB_ not modelled 6.8 10 PDB header:transferase Chain: B: PDB Molecule:glycocyamine kinase beta chain; PDBTitle: glycocyamine kinase, alpha-beta heterodimer from marine worm2 namalycastis sp. 47 c3onrI_ not modelled 6.7 21 PDB header:metal binding protein Chain: I: PDB Molecule:protein transport protein sece2; PDBTitle: crystal structure of the calcium chelating immunodominant antigen,2 calcium dodecin (rv0379),from mycobacterium tuberculosis with a novel3 calcium-binding site 48 d1m7xa3 not modelled 6.6 19 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 49 c3k8kB_ not modelled 6.5 18 PDB header:membrane protein Chain: B: PDB Molecule:alpha-amylase, susg; PDBTitle: crystal structure of susg 50 c1bf2A_ not modelled 6.3 14 PDB header:hydrolase Chain: A: PDB Molecule:isoamylase; PDBTitle: structure of pseudomonas isoamylase 51 c3mgjA_ not modelled 6.3 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein mj1480; PDBTitle: crystal structure of the saccharop_dh_n domain of mj14802 protein from methanococcus jannaschii. northeast structural3 genomics consortium target mjr83a. 52 d2aizp1 not modelled 6.0 8 Fold:Bacillus chorismate mutase-like Superfamily:OmpA-like Family:OmpA-like 53 d1g94a2 not modelled 5.8 11 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 54 c3jq3A_ not modelled 5.7 13 PDB header:transferase Chain: A: PDB Molecule:lombricine kinase; PDBTitle: crystal structure of lombricine kinase, complexed with substrate adp 55 d1y2ia_ not modelled 5.7 17 Fold:Dodecin subunit-like Superfamily:YbjQ-like Family:YbjQ-like 56 c2kfsA_ not modelled 5.5 16 PDB header:dna-binding protein Chain: A: PDB Molecule:conserved hypothetical regulatory protein; PDBTitle: nmr structure of rv2175c 57 c3amkA_ not modelled 5.4 20 PDB header:transferase Chain: A: PDB Molecule:os06g0726400 protein; PDBTitle: structure of the starch branching enzyme i (bei) from oryza sativa l

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0