Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	R	A	V	I	T	G	L	G	I	V	S	S	I	G	N	N	Q	Q	E	V	L	A	S	L	R	E	G	R	S	G	I	T	F	S	Q	E	L	K	D	S	G	M	R	S	H	V	W	G	N	V	K	L	D	T	T	G	L	I
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	R	K	V	V	R	F	M	S	D	A	S	I	Y	A	F	L	S	M	E	Q	A	I	A	D	A	G	L	S	P	E	A	Y	Q	N	N	P	R	V	G	L	I	A	G	S	G	G	G	S	P	R	F	Q	V	F	G	A	D	A	M
Secondary structure
SS confidence
Disorder																																		?																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	G	P	R	G	L	K	A	V	G	P	Y	V	V	T	K	A	M	A	S	G	V	S	A	C	L	A	T	P	F	K	I	H	G	V	N	Y	S	I	S	S	A	C	A	T	S	A	H	C	I	G	N	A	V	E	Q	I	Q	L	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?										?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		K	Q	D	I	V	F	A	G	G	G	E	E	L	C	W	E	M	A	C	E	F	D	A	M	G	A	L	S	T	K	Y	N	D	T	P	E	K	A	S	R	T	Y	D	A	H	R	D	G	F	V	I	A	G	G	G	G	M	V	V	V
Secondary structure
SS confidence
Disorder																													?	?	?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	E	L	E	H	A	L	A	R	G	A	H	I	Y	A	E	I	V	G	Y	G	A	T	S	D	G	A	D	M	V	A	P	S	G	E	G	A	V	R	C	M	K	M	A	M	H	G	V	D	T	P	I	D	Y	L	N	S	H	G	T
Secondary structure
SS confidence
Disorder																														?	?	?	?															?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	T	P	V	G	D	V	K	E	L	A	A	I	R	E	V	F	G	D	K	S	P	A	I	S	A	T	K	A	M	T	G	H	S	L	G	A	A	G	V	Q	E	A	I	Y	S	L	L	M	L	E	H	G	F	I	A	P	S	I	N
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.
Sequence		I	E	E	L	D	E	Q	A	A	G	L	N	I	V	T	E	T	T	D	R	E	L	T	T	V	M	S	N	S	F	G	F	G	G	T	N	A	T	L	V	M	R	K	L	K	D
Secondary structure
SS confidence
Disorder																																													?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2bui chain C Region: 1 - 406 Aligned: 406 Modelled: 406 Confidence: 100.0% Identity: 100% PDB header:synthase Chain: C: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase i; PDBTitle: e.coli beta-ketoacyl (acyl carrier protein) synthase i in2 complex with octanoic acid, 120k Phyre2 PDB 2vz8 chain B Region: 1 - 406 Aligned: 388 Modelled: 404 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:fatty acid synthase; PDBTitle: crystal structure of mammalian fatty acid synthase Phyre2 PDB 3lrf chain A Region: 1 - 405 Aligned: 403 Modelled: 405 Confidence: 100.0% Identity: 61% PDB header:transferase Chain: A: PDB Molecule:beta-ketoacyl synthase; PDBTitle: crystal structure of beta-ketoacyl synthase from brucella2 melitensis Phyre2 PDB 2gqd chain B Region: 2 - 405 Aligned: 400 Modelled: 404 Confidence: 100.0% Identity: 39% PDB header:transferase Chain: B: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase 2; PDBTitle: the crystal structure of b-ketoacyl-acp synthase ii (fabf)2 from staphylococcus aureus Phyre2 PDB 1e5m chain A Region: 2 - 405 Aligned: 401 Modelled: 404 Confidence: 100.0% Identity: 35% PDB header:condensing enzyme Chain: A: PDB Molecule:beta ketoacyl acyl carrier protein synthase ii; PDBTitle: beta ketoacyl acyl carrier protein synthase ii (kasii) from2 synechocystis sp. Phyre2 PDB 1tqy chain C Region: 2 - 405 Aligned: 403 Modelled: 404 Confidence: 100.0% Identity: 31% PDB header:transferase Chain: C: PDB Molecule:beta-ketoacyl synthase/acyl transferase; PDBTitle: the actinorhodin ketosynthase/chain length factor Phyre2 PDB 1oxh chain D Region: 1 - 405 Aligned: 400 Modelled: 403 Confidence: 100.0% Identity: 36% PDB header:transferase Chain: D: PDB Molecule:beta ketoacyl-acyl carrier protein synthase; PDBTitle: the crystal structure of beta-ketoacyl-[acyl carrier2 protein] synthase ii from streptococcus pneumoniae,3 triclinic form Phyre2 PDB 3o04 chain A Region: 2 - 406 Aligned: 401 Modelled: 404 Confidence: 100.0% Identity: 40% PDB header:transferase Chain: A: PDB Molecule:beta-keto-acyl carrier protein synthase ii; PDBTitle: crystal structure of the beta-keto-acyl carrier protein synthase ii2 (lmo2201) from listeria monocytogenes Phyre2 PDB 3e60 chain A Region: 1 - 406 Aligned: 404 Modelled: 406 Confidence: 100.0% Identity: 39% PDB header:transferase Chain: A: PDB Molecule:3-oxoacyl-[acyl-carrier-protein ] synthase ii; PDBTitle: crystal structure of 3-oxoacyl-(acyl carrier protein)2 synthase ii from bartonella henselae Phyre2 PDB 2gp6 chain B Region: 1 - 404 Aligned: 400 Modelled: 401 Confidence: 100.0% Identity: 32% PDB header:transferase Chain: B: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase 2; PDBTitle: x-ray crystal structure of mycobacterium tuberculosis beta-2 ketoacyl acyl carrier protein synthase ii (mtkasb) Phyre2 PDB 2iwy chain B Region: 1 - 404 Aligned: 401 Modelled: 403 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: B: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase; PDBTitle: human mitochondrial beta-ketoacyl acp synthase Phyre2 PDB 1j3n chain B Region: 1 - 404 Aligned: 401 Modelled: 404 Confidence: 100.0% Identity: 38% PDB header:transferase Chain: B: PDB Molecule:3-oxoacyl-(acyl-carrier protein) synthase ii; PDBTitle: crystal structure of 3-oxoacyl-(acyl-carrier protein)2 synthase ii from thermus thermophilus hb8 Phyre2 PDB 2qo3 chain A Region: 2 - 405 Aligned: 386 Modelled: 392 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:eryaii erythromycin polyketide synthase modules 3 and 4; PDBTitle: crystal structure of [ks3][at3] didomain from module 3 of 6-2 deoxyerthronolide b synthase Phyre2 PDB 2gfv chain A Region: 2 - 404 Aligned: 401 Modelled: 403 Confidence: 100.0% Identity: 36% PDB header:transferase Chain: A: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase 2; PDBTitle: structure of e. coli fabf (kasii) c163q mutant Phyre2 PDB 1tqy chain D Region: 4 - 404 Aligned: 396 Modelled: 401 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: D: PDB Molecule:actinorhodin polyketide putative beta-ketoacyl synthase 2; PDBTitle: the actinorhodin ketosynthase/chain length factor Phyre2 PDB 3hhd chain C Region: 2 - 406 Aligned: 387 Modelled: 405 Confidence: 100.0% Identity: 24% PDB header:transferase, hydrolase Chain: C: PDB Molecule:fatty acid synthase; PDBTitle: structure of the human fatty acid synthase ks-mat didomain2 as a framework for inhibitor design. Phyre2 PDB 2ix4 chain B Region: 2 - 404 Aligned: 402 Modelled: 403 Confidence: 100.0% Identity: 38% PDB header:transferase Chain: B: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase; PDBTitle: arabidopsis thaliana mitochondrial beta-ketoacyl acp2 synthase hexanoic acid complex Phyre2 PDB 2wgg chain A Region: 1 - 404 Aligned: 398 Modelled: 404 Confidence: 100.0% Identity: 32% PDB header:transferase Chain: A: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase 1; PDBTitle: crystal structure of mycobacterium tuberculosis c171q kasa2 variant with bound tlm Phyre2 PDB 2hg4 chain A Region: 2 - 406 Aligned: 391 Modelled: 405 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:6-deoxyerythronolide b synthase; PDBTitle: structure of the ketosynthase-acyltransferase didomain of module 52 from debs. Phyre2 PDB 2uv9 chain B Region: 4 - 405 Aligned: 399 Modelled: 402 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: B: PDB Molecule:fatty acid synthase alpha subunits; PDBTitle: crystal structure of fatty acid synthase from thermomyces2 lanuginosus at 3.1 angstrom resolution. this file contains3 the alpha subunits of the fatty acid synthase. the entire4 crystal structure consists of one heterododecameric fatty5 acid synthase and is described in remark 400 Phyre2 1 c2buiC_ 2 c2vz8B_ 3 c3lrfA_ 4 c2gqdB_ 5 c1e5mA_ 6 c1tqyC_ 7 c1oxhD_ 8 c3o04A_ 9 c3e60A_ 10 c2gp6B_ 11 c2iwyB_ 12 c1j3nB_ 13 c2qo3A_ 14 c2gfvA_ 15 c1tqyD_ 16 c3hhdC_ 17 c2ix4B_ 18 c2wggA_ 19 c2hg4A_ 20 c2uv9B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2buiC_ 100.0 100 PDB header:synthase Chain: C: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase i; PDBTitle: e.coli beta-ketoacyl (acyl carrier protein) synthase i in2 complex with octanoic acid, 120k 2 c2vz8B_ 100.0 24 PDB header:transferase Chain: B: PDB Molecule:fatty acid synthase; PDBTitle: crystal structure of mammalian fatty acid synthase 3 c3lrfA_ 100.0 61 PDB header:transferase Chain: A: PDB Molecule:beta-ketoacyl synthase; PDBTitle: crystal structure of beta-ketoacyl synthase from brucella2 melitensis 4 c2gqdB_ 100.0 39 PDB header:transferase Chain: B: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase 2; PDBTitle: the crystal structure of b-ketoacyl-acp synthase ii (fabf)2 from staphylococcus aureus 5 c1e5mA_ 100.0 35 PDB header:condensing enzyme Chain: A: PDB Molecule:beta ketoacyl acyl carrier protein synthase ii; PDBTitle: beta ketoacyl acyl carrier protein synthase ii (kasii) from2 synechocystis sp. 6 c1tqyC_ 100.0 31 PDB header:transferase Chain: C: PDB Molecule:beta-ketoacyl synthase/acyl transferase; PDBTitle: the actinorhodin ketosynthase/chain length factor 7 c1oxhD_ 100.0 36 PDB header:transferase Chain: D: PDB Molecule:beta ketoacyl-acyl carrier protein synthase; PDBTitle: the crystal structure of beta-ketoacyl-[acyl carrier2 protein] synthase ii from streptococcus pneumoniae,3 triclinic form 8 c3o04A_ 100.0 40 PDB header:transferase Chain: A: PDB Molecule:beta-keto-acyl carrier protein synthase ii; PDBTitle: crystal structure of the beta-keto-acyl carrier protein synthase ii2 (lmo2201) from listeria monocytogenes 9 c3e60A_ 100.0 39 PDB header:transferase Chain: A: PDB Molecule:3-oxoacyl-[acyl-carrier-protein ] synthase ii; PDBTitle: crystal structure of 3-oxoacyl-(acyl carrier protein)2 synthase ii from bartonella henselae 10 c2gp6B_ 100.0 32 PDB header:transferase Chain: B: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase 2; PDBTitle: x-ray crystal structure of mycobacterium tuberculosis beta-2 ketoacyl acyl carrier protein synthase ii (mtkasb) 11 c2iwyB_ 100.0 34 PDB header:transferase Chain: B: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase; PDBTitle: human mitochondrial beta-ketoacyl acp synthase 12 c1j3nB_ 100.0 38 PDB header:transferase Chain: B: PDB Molecule:3-oxoacyl-(acyl-carrier protein) synthase ii; PDBTitle: crystal structure of 3-oxoacyl-(acyl-carrier protein)2 synthase ii from thermus thermophilus hb8 13 c2qo3A_ 100.0 23 PDB header:transferase Chain: A: PDB Molecule:eryaii erythromycin polyketide synthase modules 3 and 4; PDBTitle: crystal structure of [ks3][at3] didomain from module 3 of 6-2 deoxyerthronolide b synthase 14 c2gfvA_ 100.0 36 PDB header:transferase Chain: A: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase 2; PDBTitle: structure of e. coli fabf (kasii) c163q mutant 15 c1tqyD_ 100.0 22 PDB header:transferase Chain: D: PDB Molecule:actinorhodin polyketide putative beta-ketoacyl synthase 2; PDBTitle: the actinorhodin ketosynthase/chain length factor 16 c3hhdC_ 100.0 24 PDB header:transferase, hydrolase Chain: C: PDB Molecule:fatty acid synthase; PDBTitle: structure of the human fatty acid synthase ks-mat didomain2 as a framework for inhibitor design. 17 c2ix4B_ 100.0 38 PDB header:transferase Chain: B: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase; PDBTitle: arabidopsis thaliana mitochondrial beta-ketoacyl acp2 synthase hexanoic acid complex 18 c2wggA_ 100.0 32 PDB header:transferase Chain: A: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase 1; PDBTitle: crystal structure of mycobacterium tuberculosis c171q kasa2 variant with bound tlm 19 c2hg4A_ 100.0 22 PDB header:transferase Chain: A: PDB Molecule:6-deoxyerythronolide b synthase; PDBTitle: structure of the ketosynthase-acyltransferase didomain of module 52 from debs. 20 c2uv9B_ 100.0 23 PDB header:transferase Chain: B: PDB Molecule:fatty acid synthase alpha subunits; PDBTitle: crystal structure of fatty acid synthase from thermomyces2 lanuginosus at 3.1 angstrom resolution. this file contains3 the alpha subunits of the fatty acid synthase. the entire4 crystal structure consists of one heterododecameric fatty5 acid synthase and is described in remark 400 21 c2vkzC_ not modelled 100.0 23 PDB header:transferase Chain: C: PDB Molecule:fatty acid synthase subunit alpha; PDBTitle: structure of the cerulenin-inhibited fungal fatty acid2 synthase type i multienzyme complex 22 c2uv8C_ not modelled 100.0 24 PDB header:transferase Chain: C: PDB Molecule:fatty acid synthase subunit alpha (fas2); PDBTitle: crystal structure of yeast fatty acid synthase with stalled2 acyl carrier protein at 3.1 angstrom resolution 23 d2vbaa1 not modelled 100.0 100 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 24 d1j3na1 not modelled 100.0 36 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 25 d1e5ma1 not modelled 100.0 34 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 26 d1ox0a1 not modelled 100.0 35 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 27 d2ix4a1 not modelled 100.0 33 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 28 d2gfva1 not modelled 100.0 35 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 29 d1tqya2 not modelled 100.0 39 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 30 d1tqyb2 not modelled 100.0 26 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 31 d2vbaa2 not modelled 100.0 100 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 32 d1tqya1 not modelled 100.0 24 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 33 d1e5ma2 not modelled 100.0 38 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 34 d1ox0a2 not modelled 100.0 37 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 35 d1tqyb1 not modelled 100.0 19 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 36 d2gfva2 not modelled 100.0 42 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 37 d1j3na2 not modelled 100.0 44 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 38 d2ix4a2 not modelled 100.0 44 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 39 c2ibyD_ not modelled 100.0 21 PDB header:transferase Chain: D: PDB Molecule:acetyl-coa acetyltransferase; PDBTitle: crystallographic and kinetic studies of human mitochondrial2 acetoacetyl-coa thiolase (t2): the importance of potassium and3 chloride for its structure and function 40 c3ledA_ not modelled 100.0 14 PDB header:transferase Chain: A: PDB Molecule:3-oxoacyl-acyl carrier protein synthase iii; PDBTitle: crystal structure of 3-oxoacyl-(acyl carrier protein) synthase iii2 from rhodopseudomonas palustris cga009 41 c2wuaA_ not modelled 100.0 18 PDB header:transferase Chain: A: PDB Molecule:acetoacetyl coa thiolase; PDBTitle: structure of the peroxisomal 3-ketoacyl-coa thiolase from2 sunflower 42 c2c7yB_ not modelled 100.0 14 PDB header:transferase Chain: B: PDB Molecule:3-ketoacyl-coa thiolase 2; PDBTitle: plant enzyme 43 c2d3tC_ not modelled 100.0 19 PDB header:lyase, oxidoreductase/transferase Chain: C: PDB Molecule:3-ketoacyl-coa thiolase; PDBTitle: fatty acid beta-oxidation multienzyme complex from2 pseudomonas fragi, form v 44 c3ss6B_ not modelled 100.0 23 PDB header:transferase Chain: B: PDB Molecule:acetyl-coa acetyltransferase; PDBTitle: crystal structure of the bacillus anthracis acetyl-coa2 acetyltransferase 45 c1afwB_ not modelled 100.0 17 PDB header:thiolase Chain: B: PDB Molecule:3-ketoacetyl-coa thiolase; PDBTitle: the 1.8 angstrom crystal structure of the dimeric2 peroxisomal thiolase of saccharomyces cerevisiae 46 c2vu2D_ not modelled 100.0 17 PDB header:transferase Chain: D: PDB Molecule:acetyl-coa acetyltransferase; PDBTitle: biosynthetic thiolase from z. ramigera. complex with s-2 pantetheine-11-pivalate. 47 c2iikA_ not modelled 100.0 20 PDB header:transferase Chain: A: PDB Molecule:3-ketoacyl-coa thiolase, peroxisomal; PDBTitle: crystal structure of human peroxisomal acetyl-coa acyl transferase 12 (acaa1) 48 c3goaA_ not modelled 100.0 17 PDB header:transferase Chain: A: PDB Molecule:3-ketoacyl-coa thiolase; PDBTitle: crystal structure of the salmonella typhimurium fada 3-2 ketoacyl-coa thiolase 49 c2d3mA_ not modelled 100.0 13 PDB header:transferase Chain: A: PDB Molecule:pentaketide chromone synthase; PDBTitle: pentaketide chromone synthase complexed with coenzyme a 50 c1ulqD_ not modelled 100.0 17 PDB header:transferase Chain: D: PDB Molecule:putative acetyl-coa acetyltransferase; PDBTitle: crystal structure of tt0182 from thermus thermophilus hb8 51 c1wl5A_ not modelled 100.0 22 PDB header:transferase Chain: A: PDB Molecule:acetyl-coenzyme a acetyltransferase 2; PDBTitle: human cytosolic acetoacetyl-coa thiolase 52 c3ov3A_ not modelled 99.9 14 PDB header:transferase Chain: A: PDB Molecule:curcumin synthase; PDBTitle: g211f mutant of curcumin synthase 1 from curcuma longa 53 c3fk5A_ not modelled 99.9 15 PDB header:transferase Chain: A: PDB Molecule:3-oxoacyl-synthase iii; PDBTitle: crystal structure of 3-oxoacyl-(acyl carrier protein)2 synthase iii, fabh (xoo4209) from xanthomonas oryzae pv.3 oryzae kacc10331 54 c2p0uB_ not modelled 99.9 15 PDB header:transferase Chain: B: PDB Molecule:stilbenecarboxylate synthase 2; PDBTitle: crystal structure of marchantia polymorpha stilbenecarboxylate2 synthase 2 (stcs2) 55 c1zowB_ not modelled 99.9 19 PDB header:transferase Chain: B: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase iii; PDBTitle: crystal structure of s. aureus fabh, beta-ketoacyl carrier protein2 synthase iii 56 d1teda_ not modelled 99.9 15 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 57 c1xetD_ not modelled 99.9 15 PDB header:transferase Chain: D: PDB Molecule:dihydropinosylvin synthase; PDBTitle: crystal structure of stilbene synthase from pinus2 sylvestris, complexed with methylmalonyl coa 58 c3a5qA_ not modelled 99.9 15 PDB header:transferase Chain: A: PDB Molecule:benzalacetone synthase; PDBTitle: benzalacetone synthase from rheum palmatum 59 c2ebdB_ not modelled 99.9 19 PDB header:transferase Chain: B: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase 3; PDBTitle: crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase iii2 from aquifex aeolicus vf5 60 c1ee0A_ not modelled 99.9 16 PDB header:transferase Chain: A: PDB Molecule:2-pyrone synthase; PDBTitle: 2-pyrone synthase complexed with acetoacetyl-coa 61 c3svkB_ not modelled 99.9 16 PDB header:transferase Chain: B: PDB Molecule:acetyl-coa acetyltransferase; PDBTitle: crystal structure of acetyl-coa acetyltransferase from mycobacterium2 avium 62 c2qnxA_ not modelled 99.9 16 PDB header:transferase Chain: A: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase 3; PDBTitle: crystal structure of the complex between the mycobacterium beta-2 ketoacyl-acyl carrier protein synthase iii (fabh) and 11-3 [(decyloxycarbonyl)dithio]-undecanoic acid 63 c2x3eA_ not modelled 99.9 16 PDB header:transferase Chain: A: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase 3; PDBTitle: crystal structure of 3-oxoacyl-(acyl carrier protein)2 synthase iii, fabh from pseudomonas aeruginosa pao1 64 c3il3A_ not modelled 99.9 16 PDB header:transferase Chain: A: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase 3; PDBTitle: structure of haemophilus influenzae fabh 65 c2gyoB_ not modelled 99.9 16 PDB header:transferase Chain: B: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase 3; PDBTitle: methanethiol-cys 112 inhibition complex of e. coli ketoacyl synthase2 iii (fabh) and coenzyme a 66 c3gwaA_ not modelled 99.9 14 PDB header:transferase Chain: A: PDB Molecule:3-oxoacyl-(acyl-carrier-protein) synthase iii; PDBTitle: 1.6 angstrom crystal structure of 3-oxoacyl-(acyl-carrier-protein)2 synthase iii 67 c3oitB_ not modelled 99.9 19 PDB header:transferase Chain: B: PDB Molecule:os07g0271500 protein; PDBTitle: crystal structure of curcuminoid synthase cus from oryza sativa 68 c1mzjB_ not modelled 99.8 17 PDB header:transferase Chain: B: PDB Molecule:beta-ketoacylsynthase iii; PDBTitle: crystal structure of the priming beta-ketosynthase from the2 r1128 polyketide biosynthetic pathway 69 c3h76A_ not modelled 99.8 21 PDB header:transferase Chain: A: PDB Molecule:pqs biosynthetic enzyme; PDBTitle: crystal structure of pqsd, a key enzyme in pseudomonas2 aeruginosa quinolone signal biosynthesis pathway 70 c1cmlA_ not modelled 99.8 15 PDB header:transferase Chain: A: PDB Molecule:protein (chalcone synthase); PDBTitle: chalcone synthase from alfalfa complexed with malonyl-coa 71 c1ub7A_ not modelled 99.8 21 PDB header:transferase Chain: A: PDB Molecule:3-oxoacyl-[acyl-carrier protein] synthase; PDBTitle: the crystal analysis of beta-keroacyl-[acyl carrier protein] synthase2 iii (fabh)from thermus thermophilus. 72 c3aleB_ not modelled 99.8 18 PDB header:transferase Chain: B: PDB Molecule:os07g0271500 protein; PDBTitle: a type iii polyketide synthase that produces diarylheptanoid 73 c3s3lB_ not modelled 99.8 17 PDB header:transferase Chain: B: PDB Molecule:cerj; PDBTitle: crystal structure of cerj from streptomyces tendae 74 c3il5D_ not modelled 99.8 16 PDB header:transferase Chain: D: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase 3; PDBTitle: structure of e. faecalis fabh in complex with 2-({4-bromo-3-2 [(diethylamino)sulfonyl]benzoyl}amino)benzoic acid 75 c2h84A_ not modelled 99.7 14 PDB header:biosynthetic protein, transferase Chain: A: PDB Molecule:steely1; PDBTitle: crystal structure of the c-terminal type iii polyketide synthase (pks2 iii) domain of 'steely1' (a type i/iii pks hybrid from dictyostelium) 76 c1u0mA_ not modelled 99.6 18 PDB header:biosynthetic protein Chain: A: PDB Molecule:putative polyketide synthase; PDBTitle: crystal structure of 1,3,6,8-tetrahydroxynaphthalene synthase (thns)2 from streptomyces coelicolor a3(2): a bacterial type iii polyketide3 synthase (pks) provides insights into enzymatic control of reactive4 polyketide intermediates 77 d1mzja1 not modelled 99.6 19 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 78 d1u6ea1 not modelled 99.6 20 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 79 d1u0ua1 not modelled 99.5 16 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 80 c3e1hA_ not modelled 99.5 16 PDB header:transferase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of a type iii polyketide synthase2 pksiiinc from neurospora crassa 81 c3euoB_ not modelled 99.4 13 PDB header:transferase Chain: B: PDB Molecule:type iii pentaketide synthase; PDBTitle: crystal structure of a fungal type iii polyketide synthase,2 oras 82 c2f9aA_ not modelled 99.4 16 PDB header:transferase Chain: A: PDB Molecule:3-hydroxy-3-methylglutaryl coenzyme a synthase 1; PDBTitle: hmg-coa synthase from brassica juncea in complex with f-244 83 d1ee0a1 not modelled 99.4 15 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 84 d1wdkc1 not modelled 99.4 19 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 85 d1u0va1 not modelled 99.4 12 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 86 c2p8uB_ not modelled 99.4 18 PDB header:transferase Chain: B: PDB Molecule:hydroxymethylglutaryl-coa synthase, cytoplasmic; PDBTitle: crystal structure of human 3-hydroxy-3-methylglutaryl coa synthase i 87 c2v4wB_ not modelled 99.4 18 PDB header:transferase Chain: B: PDB Molecule:hydroxymethylglutaryl-coa synthase, PDBTitle: crystal structure of human mitochondrial 3-hydroxy-3-2 methylglutaryl-coenzyme a synthase 2 (hmgcs2) 88 d1afwa2 not modelled 99.3 15 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 89 d1hnja1 not modelled 99.3 17 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 90 c1x9eB_ not modelled 99.3 16 PDB header:lyase Chain: B: PDB Molecule:hmg-coa synthase; PDBTitle: crystal structure of hmg-coa synthase from enterococcus2 faecalis 91 c3tsyA_ not modelled 99.2 15 PDB header:ligase, transferase Chain: A: PDB Molecule:fusion protein 4-coumarate--coa ligase 1, resveratrol PDBTitle: 4-coumaroyl-coa ligase::stilbene synthase fusion protein 92 c3lehA_ not modelled 99.2 13 PDB header:transferase Chain: A: PDB Molecule:putative hydroxymethylglutaryl-coa synthase; PDBTitle: the crystal structure of smu.943c from streptococcus mutans ua159 93 d1ub7a1 not modelled 99.2 23 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 94 d1ulqa1 not modelled 99.1 18 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 95 c1txtB_ not modelled 99.1 15 PDB header:lyase Chain: B: PDB Molecule:3-hydroxy-3-methylglutaryl-coa synthase; PDBTitle: staphylococcus aureus 3-hydroxy-3-methylglutaryl-coa2 synthase 96 d1m3ka1 not modelled 99.1 19 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 97 d1bi5a1 not modelled 99.1 15 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 98 d1wdkc2 not modelled 98.8 17 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 99 d1u0ma1 not modelled 98.7 19 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 100 d1xpma1 not modelled 98.7 15 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 101 d1afwa1 not modelled 98.7 13 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 102 d1ulqa2 not modelled 98.6 15 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 103 d1m3ka2 not modelled 98.6 14 Fold:Thiolase-like Superfamily:Thiolase-like Family:Thiolase-related 104 d1mzja2 not modelled 96.3 21 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 105 d1hnja2 not modelled 96.0 21 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 106 d1ub7a2 not modelled 95.5 22 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 107 d1u0ma2 not modelled 95.4 20 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 108 d1u6ea2 not modelled 95.2 20 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 109 c3lmaC_ not modelled 92.6 16 PDB header:membrane protein Chain: C: PDB Molecule:stage v sporulation protein ad (spovad); PDBTitle: crystal structure of the stage v sporulation protein ad2 (spovad) from bacillus licheniformis. northeast structural3 genomics consortium target bir6. 110 d1u0ua2 not modelled 74.3 16 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 111 d1ee0a2 not modelled 71.9 18 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 112 d1a2za_ not modelled 63.6 27 Fold:Phosphorylase/hydrolase-like Superfamily:Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) Family:Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) 113 d1bi5a2 not modelled 40.6 18 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 114 c3gpiA_ not modelled 35.0 30 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:nad-dependent epimerase/dehydratase; PDBTitle: structure of putative nad-dependent epimerase/dehydratase2 from methylobacillus flagellatus 115 c3rfxB_ not modelled 32.1 63 PDB header:oxidoreductase Chain: B: PDB Molecule:uronate dehydrogenase; PDBTitle: crystal structure of uronate dehydrogenase from agrobacterium2 tumefaciens, y136a mutant complexed with nad 116 c3dhnA_ not modelled 31.2 38 PDB header:isomerase, lyase Chain: A: PDB Molecule:nad-dependent epimerase/dehydratase; PDBTitle: crystal structure of the putative epimerase q89z24_bactn2 from bacteroides thetaiotaomicron. northeast structural3 genomics consortium target btr310. 117 c3kd9B_ not modelled 29.0 50 PDB header:oxidoreductase Chain: B: PDB Molecule:coenzyme a disulfide reductase; PDBTitle: crystal structure of pyridine nucleotide disulfide oxidoreductase from2 pyrococcus horikoshii 118 d1bxka_ not modelled 27.5 50 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 119 d1oc2a_ not modelled 27.1 38 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 120 c2q1wC_ not modelled 26.7 63 PDB header:sugar binding protein Chain: C: PDB Molecule:putative nucleotide sugar epimerase/ dehydratase; PDBTitle: crystal structure of the bordetella bronchiseptica enzyme wbmh in2 complex with nad+

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0