Phyre 2 Results for P09546

Email	l.a.kelley@imperial.ac.uk
Description	P09546
Date	Wed Jan 25 15:20:14 GMT 2012
Unique Job ID	f64d1b763e685649

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c3hazA_

Top template information

PDB header:oxidoreductase
Chain: A: PDB Molecule:proline dehydrogenase;
PDBTitle: crystal structure of bifunctional proline utilization a2 (puta) protein

Confidence and coverage

Confidence:

100.0%

Coverage:

73%

965 residues ( 73% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M G T T T M G V K L D D A T R E R I K S A A T R I D R T P H W L I K Q A I F S Y L E Q L E N S D T L P E L P A L L S G A

Secondary structure

SS confidence

Disorder ? ? ? ?
?
? ?
? ? ? ? ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence A N E S D E A P T P A E E P H Q P F L D F A E Q I L P Q S V S R A A I T A A Y R R P E T E A V S M L L E Q A R L P Q P V

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence A E Q A H K L A Y Q L A D K L R N Q K N A S G R A G M V Q G L L Q E F S L S S Q E G V A L M C L A E A L L R I P D K A T

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence R D A L I R D K I S N G N W Q S H I G R S P S L F V N A A T W G L L F T G K L V S T H N E A S L S R S L N R I I G K S G

Secondary structure

SS confidence

Disorder
?
? ?
? ? ?
? ?
? ?
?
? ? ?
? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence E P L I R K G V D M A M R L M G E Q F V T G E T I A E A L A N A R K L E E K G F R Y S Y D M L G E A A L T A A D A Q A Y

Secondary structure

SS confidence

Disorder ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence M V S Y Q Q A I H A I G K A S N G R G I Y E G P G I S I K L S A L H P R Y S R A Q Y D R V M E E L Y P R L K S L T L L A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence R Q Y D I G I N I D A E E S D R L E I S L D L L E K L C F E P E L A G W N G I G F V I Q A Y Q K R C P L V I D Y L I D L

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence A T R S R R R L M I R L V K G A Y W D S E I K R A Q M D G L E G Y P V Y T R K V Y T D V S Y L A C A K K L L A V P N L I

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence Y P Q F A T H N A H T L A A I Y Q L A G Q N Y Y P G Q Y E F Q C L H G M G E P L Y E Q V T G K V A D G K L N R P C R I Y

Secondary structure

SS confidence

Disorder
? ?
? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence A P V G T H E T L L A Y L V R R L L E N G A N T S F V N R I A D T S L P L D E L V A D P V T A V E K L A Q Q E G Q T G L

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence P H P K I P L P R D L Y G H G R D N S A G L D L A N E H R L A S L S S A L L N S A L Q K W Q A L P M L E Q P V A A G E M

Secondary structure

SS confidence

Disorder ? ? ? ?
?
? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence S P V I N P A E P K D I V G Y V R E A T P R E V E Q A L E S A V N N A P I W F A T P P A E R A A I L H R A A V L M E S Q

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence M Q Q L I G I L V R E A G K T F S N A I A E V R E A V D F L H Y Y A G Q V R D D F A N E T H R P L G P V V C I S P W N F

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence P L A I F T G Q I A A A L A A G N S V L A K P A E Q T P L I A A Q G I A I L L E A G V P P G V V Q L L P G R G E T V G A

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence Q L T G D D R V R G V M F T G S T E V A T L L Q R N I A S R L D A Q G R P I P L I A E T G G M N A M I V D S S A L T E Q

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence V V V D V L A S A F D S A G Q R C S A L R V L C L Q D E I A D H T L K M L R G A M A E C R M G N P G R L T T D I G P V I

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence D S E A K A N I E R H I Q T M R S K G R P V F Q A V R E N S E D A R E W Q S G T F V A P T L I E L D D F A E L Q K E V F

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence G P V L H V V R Y N R N Q L P E L I E Q I N A S G Y G L T L G V H T R I D E T I A Q V T G S A H V G N L Y V N R N M V G

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence A V V G V Q P F G G E G L S G T G P K A G G P L Y L Y R L L A N R P E S A L A V T L A R Q D A K Y P V D A Q L K A A L T

Secondary structure

SS confidence

Disorder
?
?
?
?
? ? ? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence Q P L N A L R E W A A N R P E L Q A L C T Q Y G E L A Q A G T Q R L L P G P T G E R N T W T L L P R E R V L C I A D D E

Secondary structure

SS confidence

Disorder ?
?
? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence Q D A L T Q L A A V L A V G S Q V L W P D D A L H R Q L V K A L P S A V S E R I Q L A K A E N I T A Q P F D A V I F H G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence D S D Q L R A L C E A V A A R D G T I V S V Q G F A R G E S N I L L E R L Y I E R S L S V N T A A A G G N A S L M T I G

Secondary structure

SS confidence

Disorder
? ?
? ? ?

Disorder confidence

Sequence

Secondary structure

SS confidence

Disorder

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3haz chain A

Region: 91 - 1123
Aligned: 965
Modelled: 999
Confidence: 100.0%
Identity: 50%
PDB header:oxidoreductase
Chain: A: PDB Molecule:proline dehydrogenase;
PDBTitle: crystal structure of bifunctional proline utilization a2 (puta) protein

Phyre2

PDB 1k87 chain A

Region: 87 - 612
Aligned: 514
Modelled: 526
Confidence: 100.0%
Identity: 99%
PDB header:oxidoreductase
Chain: A: PDB Molecule:proline dehydrogenase;
PDBTitle: crystal structure of e.coli puta (residues 1-669)

Phyre2

PDB 3e2s chain A

Region: 88 - 610
Aligned: 468
Modelled: 468
Confidence: 100.0%
Identity: 100%
PDB header:oxidoreductase
Chain: A: PDB Molecule:proline dehydrogenase;
PDBTitle: crystal structure reduced puta86-630 mutant y540s complexed with l-2 proline

Phyre2

PDB 1tj2 chain A

Region: 88 - 610
Aligned: 450
Modelled: 449
Confidence: 100.0%
Identity: 100%
PDB header:oxidoreductase
Chain: A: PDB Molecule:bifunctional puta protein;
PDBTitle: crystal structure of e. coli puta proline dehydrogenase domain2 (residues 86-669) complexed with acetate

Phyre2

PDB 3qan chain B

Region: 614 - 1116
Aligned: 494
Modelled: 503
Confidence: 100.0%
Identity: 35%
PDB header:oxidoreductase
Chain: B: PDB Molecule:1-pyrroline-5-carboxylate dehydrogenase 1;
PDBTitle: crystal structure of 1-pyrroline-5-carboxylate dehydrogenase from2 bacillus halodurans

Phyre2

PDB 1uzb chain A

Region: 611 - 1116
Aligned: 496
Modelled: 506
Confidence: 100.0%
Identity: 37%
Fold: ALDH-like
Superfamily: ALDH-like
Family: ALDH-like

Phyre2

PDB 3ed6 chain B

Region: 643 - 1125
Aligned: 469
Modelled: 483
Confidence: 100.0%
Identity: 27%
PDB header:oxidoreductase
Chain: B: PDB Molecule:betaine aldehyde dehydrogenase;
PDBTitle: 1.7 angstrom resolution crystal structure of betaine aldehyde2 dehydrogenase (betb) from staphylococcus aureus

Phyre2

PDB 1a4s chain A

Region: 643 - 1125
Aligned: 470
Modelled: 483
Confidence: 100.0%
Identity: 25%
Fold: ALDH-like
Superfamily: ALDH-like
Family: ALDH-like

Phyre2

PDB 2o2q chain A

Region: 648 - 1116
Aligned: 454
Modelled: 469
Confidence: 100.0%
Identity: 27%
PDB header:oxidoreductase
Chain: A: PDB Molecule:formyltetrahydrofolate dehydrogenase;
PDBTitle: crystal structure of the c-terminal domain of rat2 10'formyltetrahydrofolate dehydrogenase in complex with nadp

Phyre2

PDB 2d4e chain B

Region: 630 - 1126
Aligned: 483
Modelled: 497
Confidence: 100.0%
Identity: 28%
PDB header:oxidoreductase
Chain: B: PDB Molecule:5-carboxymethyl-2-hydroxymuconate semialdehyde
PDBTitle: crystal structure of the hpcc from thermus thermophilus hb8

Phyre2

PDB 2jg7 chain G

Region: 648 - 1131
Aligned: 465
Modelled: 484
Confidence: 100.0%
Identity: 26%
PDB header:oxidoreductase
Chain: G: PDB Molecule:antiquitin;
PDBTitle: crystal structure of seabream antiquitin and elucidation of2 its substrate specificity

Phyre2

PDB 1bxs chain A

Region: 646 - 1113
Aligned: 451
Modelled: 460
Confidence: 100.0%
Identity: 30%
Fold: ALDH-like
Superfamily: ALDH-like
Family: ALDH-like

Phyre2

PDB 2ve5 chain H

Region: 646 - 1114
Aligned: 456
Modelled: 467
Confidence: 100.0%
Identity: 28%
PDB header:oxidoreductase
Chain: H: PDB Molecule:betaine aldehyde dehydrogenase;
PDBTitle: crystallographic structure of betaine aldehyde2 dehydrogenase from pseudomonas aeruginosa

Phyre2

PDB 3iwk chain B

Region: 650 - 1123
Aligned: 458
Modelled: 474
Confidence: 100.0%
Identity: 26%
PDB header:oxidoreductase
Chain: B: PDB Molecule:aminoaldehyde dehydrogenase;
PDBTitle: crystal structure of aminoaldehyde dehydrogenase 1 from2 pisum sativum (psamadh1)

Phyre2

PDB 3rh9 chain A

Region: 646 - 1116
Aligned: 454
Modelled: 471
Confidence: 100.0%
Identity: 27%
PDB header:oxidoreductase
Chain: A: PDB Molecule:succinate-semialdehyde dehydrogenase (nad(p)(+));
PDBTitle: the crystal structure of oxidoreductase from marinobacter aquaeolei

Phyre2

PDB 1o9j chain A

Region: 641 - 1114
Aligned: 457
Modelled: 473
Confidence: 100.0%
Identity: 29%
Fold: ALDH-like
Superfamily: ALDH-like
Family: ALDH-like

Phyre2

PDB 1t90 chain B

Region: 646 - 1116
Aligned: 455
Modelled: 471
Confidence: 100.0%
Identity: 26%
PDB header:oxidoreductase
Chain: B: PDB Molecule:probable methylmalonate-semialdehyde
PDBTitle: crystal structure of methylmalonate semialdehyde2 dehydrogenase from bacillus subtilis

Phyre2

PDB 1ag8 chain A

Region: 642 - 1113
Aligned: 455
Modelled: 472
Confidence: 100.0%
Identity: 28%
Fold: ALDH-like
Superfamily: ALDH-like
Family: ALDH-like

Phyre2

PDB 1o04 chain A

Region: 645 - 1115
Aligned: 454
Modelled: 471
Confidence: 100.0%
Identity: 28%
Fold: ALDH-like
Superfamily: ALDH-like
Family: ALDH-like

Phyre2

PDB 3b4w chain A

Region: 648 - 1114
Aligned: 449
Modelled: 467
Confidence: 100.0%
Identity: 27%
PDB header:oxidoreductase
Chain: A: PDB Molecule:aldehyde dehydrogenase;
PDBTitle: crystal structure of mycobacterium tuberculosis aldehyde dehydrogenase2 complexed with nad+

Phyre2

PDB 2ay0 chain A domain 1

Region: 3 - 45
Aligned: 43
Modelled: 43
Confidence: 99.7%
Identity: 98%
Fold: Ribbon-helix-helix
Superfamily: Ribbon-helix-helix
Family: PutA pre-N-terminal region-like

Phyre2

PDB 2rbf chain B

Region: 4 - 48
Aligned: 45
Modelled: 45
Confidence: 99.5%
Identity: 100%
PDB header:oxidoreductase/dna
Chain: B: PDB Molecule:bifunctional protein puta;
PDBTitle: structure of the ribbon-helix-helix domain of escherichia coli puta2 (puta52) complexed with operator dna (o2)

Phyre2

100

Detailed template information

#	Template	Alignment Coverage	3D Model	Confidence	% i.d.	Template Information

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server

Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]

If you use the binding site predictions from 3DLigandSite, please also cite:

3DLigandSite: predicting ligand-binding sites using similar structures.

Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]

Imperial College London

Lawrence Kelley, Benjamin Jefferys

Disclaimer

Terms and Conditions

Component software

Template detection: HHpred 1.51

Secondary structure prediction: Psi-pred 2.5

Disorder prediction: Disopred 2.4

Transmembrane prediction: Memsat_SVM

Multi-template modelling and ab initio: Poing 1.0

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	G	T	T	T	M	G	V	K	L	D	D	A	T	R	E	R	I	K	S	A	A	T	R	I	D	R	T	P	H	W	L	I	K	Q	A	I	F	S	Y	L	E	Q	L	E	N	S	D	T	L	P	E	L	P	A	L	L	S	G	A
Secondary structure
SS confidence
Disorder	?	?	?	?			?																	?	?																				?	?	?	?	?	?	?	?					?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	A	N	E	S	D	E	A	P	T	P	A	E	E	P	H	Q	P	F	L	D	F	A	E	Q	I	L	P	Q	S	V	S	R	A	A	I	T	A	A	Y	R	R	P	E	T	E	A	V	S	M	L	L	E	Q	A	R	L	P	Q	P	V
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?																										?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	A	E	Q	A	H	K	L	A	Y	Q	L	A	D	K	L	R	N	Q	K	N	A	S	G	R	A	G	M	V	Q	G	L	L	Q	E	F	S	L	S	S	Q	E	G	V	A	L	M	C	L	A	E	A	L	L	R	I	P	D	K	A	T
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	R	D	A	L	I	R	D	K	I	S	N	G	N	W	Q	S	H	I	G	R	S	P	S	L	F	V	N	A	A	T	W	G	L	L	F	T	G	K	L	V	S	T	H	N	E	A	S	L	S	R	S	L	N	R	I	I	G	K	S	G
Secondary structure
SS confidence
Disorder										?		?	?				?	?	?			?	?														?	?			?		?	?	?														?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	E	P	L	I	R	K	G	V	D	M	A	M	R	L	M	G	E	Q	F	V	T	G	E	T	I	A	E	A	L	A	N	A	R	K	L	E	E	K	G	F	R	Y	S	Y	D	M	L	G	E	A	A	L	T	A	A	D	A	Q	A	Y
Secondary structure
SS confidence
Disorder	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	M	V	S	Y	Q	Q	A	I	H	A	I	G	K	A	S	N	G	R	G	I	Y	E	G	P	G	I	S	I	K	L	S	A	L	H	P	R	Y	S	R	A	Q	Y	D	R	V	M	E	E	L	Y	P	R	L	K	S	L	T	L	L	A
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	R	Q	Y	D	I	G	I	N	I	D	A	E	E	S	D	R	L	E	I	S	L	D	L	L	E	K	L	C	F	E	P	E	L	A	G	W	N	G	I	G	F	V	I	Q	A	Y	Q	K	R	C	P	L	V	I	D	Y	L	I	D	L
Secondary structure
SS confidence
Disorder																																	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	A	T	R	S	R	R	R	L	M	I	R	L	V	K	G	A	Y	W	D	S	E	I	K	R	A	Q	M	D	G	L	E	G	Y	P	V	Y	T	R	K	V	Y	T	D	V	S	Y	L	A	C	A	K	K	L	L	A	V	P	N	L	I
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	Y	P	Q	F	A	T	H	N	A	H	T	L	A	A	I	Y	Q	L	A	G	Q	N	Y	Y	P	G	Q	Y	E	F	Q	C	L	H	G	M	G	E	P	L	Y	E	Q	V	T	G	K	V	A	D	G	K	L	N	R	P	C	R	I	Y
Secondary structure
SS confidence
Disorder																					?	?		?	?	?																								?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	A	P	V	G	T	H	E	T	L	L	A	Y	L	V	R	R	L	L	E	N	G	A	N	T	S	F	V	N	R	I	A	D	T	S	L	P	L	D	E	L	V	A	D	P	V	T	A	V	E	K	L	A	Q	Q	E	G	Q	T	G	L
Secondary structure
SS confidence
Disorder																																																			?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	P	H	P	K	I	P	L	P	R	D	L	Y	G	H	G	R	D	N	S	A	G	L	D	L	A	N	E	H	R	L	A	S	L	S	S	A	L	L	N	S	A	L	Q	K	W	Q	A	L	P	M	L	E	Q	P	V	A	A	G	E	M
Secondary structure
SS confidence
Disorder	?	?	?	?		?		?	?	?	?	?	?	?																												?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	S	P	V	I	N	P	A	E	P	K	D	I	V	G	Y	V	R	E	A	T	P	R	E	V	E	Q	A	L	E	S	A	V	N	N	A	P	I	W	F	A	T	P	P	A	E	R	A	A	I	L	H	R	A	A	V	L	M	E	S	Q
Secondary structure
SS confidence
Disorder																																								?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	M	Q	Q	L	I	G	I	L	V	R	E	A	G	K	T	F	S	N	A	I	A	E	V	R	E	A	V	D	F	L	H	Y	Y	A	G	Q	V	R	D	D	F	A	N	E	T	H	R	P	L	G	P	V	V	C	I	S	P	W	N	F
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	P	L	A	I	F	T	G	Q	I	A	A	A	L	A	A	G	N	S	V	L	A	K	P	A	E	Q	T	P	L	I	A	A	Q	G	I	A	I	L	L	E	A	G	V	P	P	G	V	V	Q	L	L	P	G	R	G	E	T	V	G	A
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	Q	L	T	G	D	D	R	V	R	G	V	M	F	T	G	S	T	E	V	A	T	L	L	Q	R	N	I	A	S	R	L	D	A	Q	G	R	P	I	P	L	I	A	E	T	G	G	M	N	A	M	I	V	D	S	S	A	L	T	E	Q
Secondary structure
SS confidence
Disorder																															?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	V	V	V	D	V	L	A	S	A	F	D	S	A	G	Q	R	C	S	A	L	R	V	L	C	L	Q	D	E	I	A	D	H	T	L	K	M	L	R	G	A	M	A	E	C	R	M	G	N	P	G	R	L	T	T	D	I	G	P	V	I
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	D	S	E	A	K	A	N	I	E	R	H	I	Q	T	M	R	S	K	G	R	P	V	F	Q	A	V	R	E	N	S	E	D	A	R	E	W	Q	S	G	T	F	V	A	P	T	L	I	E	L	D	D	F	A	E	L	Q	K	E	V	F
Secondary structure
SS confidence
Disorder																													?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	G	P	V	L	H	V	V	R	Y	N	R	N	Q	L	P	E	L	I	E	Q	I	N	A	S	G	Y	G	L	T	L	G	V	H	T	R	I	D	E	T	I	A	Q	V	T	G	S	A	H	V	G	N	L	Y	V	N	R	N	M	V	G
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	A	V	V	G	V	Q	P	F	G	G	E	G	L	S	G	T	G	P	K	A	G	G	P	L	Y	L	Y	R	L	L	A	N	R	P	E	S	A	L	A	V	T	L	A	R	Q	D	A	K	Y	P	V	D	A	Q	L	K	A	A	L	T
Secondary structure
SS confidence
Disorder												?				?			?																				?		?	?	?	?	?	?	?	?	?	?								?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	Q	P	L	N	A	L	R	E	W	A	A	N	R	P	E	L	Q	A	L	C	T	Q	Y	G	E	L	A	Q	A	G	T	Q	R	L	L	P	G	P	T	G	E	R	N	T	W	T	L	L	P	R	E	R	V	L	C	I	A	D	D	E
Secondary structure
SS confidence
Disorder	?		?																										?	?	?		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	Q	D	A	L	T	Q	L	A	A	V	L	A	V	G	S	Q	V	L	W	P	D	D	A	L	H	R	Q	L	V	K	A	L	P	S	A	V	S	E	R	I	Q	L	A	K	A	E	N	I	T	A	Q	P	F	D	A	V	I	F	H	G
Secondary structure
SS confidence
Disorder																?	?	?	?	?	?	?	?	?	?																							?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	D	S	D	Q	L	R	A	L	C	E	A	V	A	A	R	D	G	T	I	V	S	V	Q	G	F	A	R	G	E	S	N	I	L	L	E	R	L	Y	I	E	R	S	L	S	V	N	T	A	A	A	G	G	N	A	S	L	M	T	I	G
Secondary structure
SS confidence
Disorder																										?	?																															?	?	?
Disorder confidence


Sequence
Secondary structure
SS confidence
Disorder
Disorder confidence