Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	E	A	E	A	R	P	T	N	F	I	R	Q	I	I	D	E	D	L	A	S	G	K	H	T	T	V	H	T	R	F	P	P	E	P	N	G	Y	L	H	I	G	H	A	K	S	I	C	L	N	F	G	I	A	Q	D	Y	K	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?										?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	C	N	L	R	F	D	D	T	N	P	V	K	E	D	I	E	Y	V	E	S	I	K	N	D	V	E	W	L	G	F	H	W	S	G	N	V	R	Y	S	S	D	Y	F	D	Q	L	H	A	Y	A	I	E	L	I	N	K	G	L	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Y	V	D	E	L	T	P	E	Q	I	R	E	Y	R	G	T	L	T	Q	P	G	K	N	S	P	Y	R	D	R	S	V	E	E	N	L	A	L	F	E	K	M	R	A	G	G	F	E	E	G	K	A	C	L	R	A	K	I	D	M	A
Secondary structure
SS confidence
Disorder																				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	P	F	I	V	M	R	D	P	V	L	Y	R	I	K	F	A	E	H	H	Q	T	G	N	K	W	C	I	Y	P	M	Y	D	F	T	H	C	I	S	D	A	L	E	G	I	T	H	S	L	C	T	L	E	F	Q	D	N	R	R	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Y	D	W	V	L	D	N	I	T	I	P	V	H	P	R	Q	Y	E	F	S	R	L	N	L	E	Y	T	V	M	S	K	R	K	L	N	L	L	V	T	D	K	H	V	E	G	W	D	D	P	R	M	P	T	I	S	G	L	R	R	R
Secondary structure
SS confidence
Disorder																											?										?	?	?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	Y	T	A	A	S	I	R	E	F	C	K	R	I	G	V	T	K	Q	D	N	T	I	E	M	A	S	L	E	S	C	I	R	E	D	L	N	E	N	A	P	R	A	M	A	V	I	D	P	V	K	L	V	I	E	N	Y	Q	G	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	E	M	V	T	M	P	N	H	P	N	K	P	E	M	G	S	R	Q	V	P	F	S	G	E	I	W	I	D	R	A	D	F	R	E	E	A	N	K	Q	Y	K	R	L	V	L	G	K	E	V	R	L	R	N	A	Y	V	I	K	A
Secondary structure
SS confidence
Disorder															?																			?	?	?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		E	R	V	E	K	D	A	E	G	N	I	T	T	I	F	C	T	Y	D	A	D	T	L	S	K	D	P	A	D	G	R	K	V	K	G	V	I	H	W	V	S	A	A	H	A	L	P	V	E	I	R	L	Y	D	R	L	F	S	V	P
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		N	P	G	A	A	D	D	F	L	S	V	I	N	P	E	S	L	V	I	K	Q	G	F	A	E	P	S	L	K	D	A	V	A	G	K	A	F	Q	F	E	R	E	G	Y	F	C	L	D	S	R	H	S	T	A	E	K	P	V	F	N
Secondary structure
SS confidence
Disorder					?	?																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.
Sequence		R	T	V	G	L	R	D	T	W	A	K	V	G	E
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1exd chain A Region: 9 - 548 Aligned: 529 Modelled: 540 Confidence: 100.0% Identity: 100% PDB header:ligase/rna Chain: A: PDB Molecule:glutaminyl-trna synthetase; PDBTitle: crystal structure of a tight-binding glutamine trna bound2 to glutamine aminoacyl trna synthetase Phyre2 PDB 2hz7 chain A Region: 4 - 549 Aligned: 536 Modelled: 546 Confidence: 100.0% Identity: 49% PDB header:ligase Chain: A: PDB Molecule:glutaminyl-trna synthetase; PDBTitle: crystal structure of the glutaminyl-trna synthetase from2 deinococcus radiodurans Phyre2 PDB 3aii chain A Region: 19 - 542 Aligned: 451 Modelled: 475 Confidence: 100.0% Identity: 33% PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: archaeal non-discriminating glutamyl-trna synthetase from2 methanothermobacter thermautotrophicus Phyre2 PDB 1gtr chain A domain 2 Region: 9 - 339 Aligned: 331 Modelled: 331 Confidence: 100.0% Identity: 100% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 1j09 chain A domain 2 Region: 28 - 343 Aligned: 289 Modelled: 293 Confidence: 100.0% Identity: 25% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 3al0 chain C Region: 13 - 336 Aligned: 289 Modelled: 296 Confidence: 100.0% Identity: 22% PDB header:ligase/rna Chain: C: PDB Molecule:glutamyl-trna(gln) amidotransferase subunit c, glutamyl- PDBTitle: crystal structure of the glutamine transamidosome from thermotoga2 maritima in the glutamylation state. Phyre2 PDB 1nzj chain A Region: 27 - 346 Aligned: 268 Modelled: 290 Confidence: 100.0% Identity: 22% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 2cfo chain A Region: 27 - 340 Aligned: 290 Modelled: 291 Confidence: 100.0% Identity: 28% PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: non-discriminating glutamyl-trna synthetase from2 thermosynechococcus elongatus in complex with glu Phyre2 PDB 2ja2 chain A Region: 23 - 340 Aligned: 283 Modelled: 283 Confidence: 100.0% Identity: 20% PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: mycobacterium tuberculosis glutamyl-trna synthetase Phyre2 PDB 1g59 chain A Region: 28 - 341 Aligned: 277 Modelled: 277 Confidence: 100.0% Identity: 25% PDB header:ligase/rna Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: glutamyl-trna synthetase complexed with trna(glu). Phyre2 PDB 3afh chain A Region: 28 - 336 Aligned: 274 Modelled: 293 Confidence: 100.0% Identity: 22% PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase 2; PDBTitle: crystal structure of thermotoga maritima nondiscriminating glutamyl-2 trna synthetase in complex with a glutamyl-amp analog Phyre2 PDB 2o5r chain A Region: 28 - 344 Aligned: 298 Modelled: 301 Confidence: 100.0% Identity: 24% PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase 1; PDBTitle: crystal structure of glutamyl-trna synthetase 1 (ec 6.1.1.17)2 (glutamate-trna ligase 1) (glurs 1) (tm1351) from thermotoga maritima3 at 2.5 a resolution Phyre2 PDB 1gtr chain A domain 1 Region: 340 - 548 Aligned: 198 Modelled: 209 Confidence: 100.0% Identity: 99% Fold: Ribosomal protein L25-like Superfamily: Ribosomal protein L25-like Family: Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain Phyre2 PDB 1irx chain A Region: 13 - 324 Aligned: 268 Modelled: 275 Confidence: 100.0% Identity: 12% PDB header:ligase Chain: A: PDB Molecule:lysyl-trna synthetase; PDBTitle: crystal structure of class i lysyl-trna synthetase Phyre2 PDB 1f7u chain A domain 2 Region: 24 - 332 Aligned: 272 Modelled: 294 Confidence: 100.0% Identity: 13% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 1li5 chain A domain 2 Region: 26 - 331 Aligned: 246 Modelled: 253 Confidence: 99.9% Identity: 16% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 3sp1 chain B Region: 33 - 335 Aligned: 234 Modelled: 241 Confidence: 99.9% Identity: 18% PDB header:ligase Chain: B: PDB Molecule:cysteinyl-trna synthetase; PDBTitle: crystal structure of cysteinyl-trna synthetase (cyss) from borrelia2 burgdorferi Phyre2 PDB 1u0b chain B Region: 25 - 335 Aligned: 260 Modelled: 266 Confidence: 99.9% Identity: 17% PDB header:ligase/rna Chain: B: PDB Molecule:cysteinyl trna; PDBTitle: crystal structure of cysteinyl-trna synthetase binary2 complex with trnacys Phyre2 PDB 2d5b chain A domain 2 Region: 28 - 337 Aligned: 279 Modelled: 283 Confidence: 99.9% Identity: 14% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 1pfv chain A domain 2 Region: 28 - 338 Aligned: 294 Modelled: 296 Confidence: 99.9% Identity: 12% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 1 c1exdA_ 2 c2hz7A_ 3 c3aiiA_ 4 d1gtra2 5 d1j09a2 6 c3al0C_ 7 d1nzja_ 8 c2cfoA_ 9 c2ja2A_ 10 c1g59A_ 11 c3afhA_ 12 c2o5rA_ 13 d1gtra1 14 c1irxA_ 15 d1f7ua2 16 d1li5a2 17 c3sp1B_ 18 c1u0bB_ 19 d2d5ba2 20 d1pfva2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1exdA_ 100.0 100 PDB header:ligase/rna Chain: A: PDB Molecule:glutaminyl-trna synthetase; PDBTitle: crystal structure of a tight-binding glutamine trna bound2 to glutamine aminoacyl trna synthetase 2 c2hz7A_ 100.0 49 PDB header:ligase Chain: A: PDB Molecule:glutaminyl-trna synthetase; PDBTitle: crystal structure of the glutaminyl-trna synthetase from2 deinococcus radiodurans 3 c3aiiA_ 100.0 33 PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: archaeal non-discriminating glutamyl-trna synthetase from2 methanothermobacter thermautotrophicus 4 d1gtra2 100.0 100 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 5 d1j09a2 100.0 25 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 6 c3al0C_ 100.0 22 PDB header:ligase/rna Chain: C: PDB Molecule:glutamyl-trna(gln) amidotransferase subunit c, glutamyl- PDBTitle: crystal structure of the glutamine transamidosome from thermotoga2 maritima in the glutamylation state. 7 d1nzja_ 100.0 22 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 8 c2cfoA_ 100.0 28 PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: non-discriminating glutamyl-trna synthetase from2 thermosynechococcus elongatus in complex with glu 9 c2ja2A_ 100.0 20 PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: mycobacterium tuberculosis glutamyl-trna synthetase 10 c1g59A_ 100.0 25 PDB header:ligase/rna Chain: A: PDB Molecule:glutamyl-trna synthetase; PDBTitle: glutamyl-trna synthetase complexed with trna(glu). 11 c3afhA_ 100.0 22 PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase 2; PDBTitle: crystal structure of thermotoga maritima nondiscriminating glutamyl-2 trna synthetase in complex with a glutamyl-amp analog 12 c2o5rA_ 100.0 24 PDB header:ligase Chain: A: PDB Molecule:glutamyl-trna synthetase 1; PDBTitle: crystal structure of glutamyl-trna synthetase 1 (ec 6.1.1.17)2 (glutamate-trna ligase 1) (glurs 1) (tm1351) from thermotoga maritima3 at 2.5 a resolution 13 d1gtra1 100.0 99 Fold:Ribosomal protein L25-like Superfamily:Ribosomal protein L25-like Family:Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain 14 c1irxA_ 100.0 12 PDB header:ligase Chain: A: PDB Molecule:lysyl-trna synthetase; PDBTitle: crystal structure of class i lysyl-trna synthetase 15 d1f7ua2 100.0 13 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 16 d1li5a2 99.9 16 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 17 c3sp1B_ 99.9 18 PDB header:ligase Chain: B: PDB Molecule:cysteinyl-trna synthetase; PDBTitle: crystal structure of cysteinyl-trna synthetase (cyss) from borrelia2 burgdorferi 18 c1u0bB_ 99.9 17 PDB header:ligase/rna Chain: B: PDB Molecule:cysteinyl trna; PDBTitle: crystal structure of cysteinyl-trna synthetase binary2 complex with trnacys 19 d2d5ba2 99.9 14 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 20 d1pfva2 99.9 12 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 21 c3c8zB_ not modelled 99.9 14 PDB header:ligase Chain: B: PDB Molecule:cysteinyl-trna synthetase; PDBTitle: the 1.6 a crystal structure of mshc: the rate limiting2 enzyme in the mycothiol biosynthetic pathway 22 c2ct8A_ not modelled 99.8 16 PDB header:ligase/rna Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: crystal structure of aquifex aeolicus methionyl-trna2 synthetase complexed with trna(met) and methionyl-adenylate3 anologue 23 c2x1lC_ not modelled 99.8 15 PDB header:ligase Chain: C: PDB Molecule:methionyl-trna synthetase; PDBTitle: crystal structure of mycobacterium smegmatis methionyl-trna2 synthetase in complex with methionine and adenosine 24 d1irxa2 not modelled 99.7 15 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 25 c1woyA_ not modelled 99.7 18 PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: crystal structure of methionyl trna synthetase y225f mutant2 from thermus thermophilus 26 c3tqoA_ not modelled 99.7 14 PDB header:ligase Chain: A: PDB Molecule:cysteinyl-trna synthetase; PDBTitle: structure of the cysteinyl-trna synthetase (cyss) from coxiella2 burnetii. 27 c3fnrA_ not modelled 99.6 12 PDB header:transferase Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: crystal structure of putative arginyl t-rna synthetase from2 campylobacter jejuni; 28 d1rqga2 not modelled 99.6 14 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 29 d1ivsa4 not modelled 99.5 19 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 30 c1pfuA_ not modelled 99.4 12 PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: methionyl-trna synthetase from escherichia coli complexed2 with methionine phosphinate 31 c3kflA_ not modelled 99.4 13 PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: leishmania major methionyl-trna synthetase in complex with2 methionyladenylate and pyrophosphate 32 d1ilea3 not modelled 99.4 17 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 33 c1rqgA_ not modelled 99.3 16 PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: methionyl-trna synthetase from pyrococcus abyssi 34 d1ffya3 not modelled 99.3 21 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 35 d1h3na3 not modelled 99.2 16 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 36 d1iq0a2 not modelled 99.2 18 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 37 c1f7uA_ not modelled 99.1 18 PDB header:ligase/rna Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: crystal structure of the arginyl-trna synthetase complexed with the2 trna(arg) and l-arg 38 c2zufA_ not modelled 99.1 16 PDB header:ligase/rna Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: crystal structure of pyrococcus horikoshii arginyl-trna2 synthetase complexed with trna(arg) 39 c1iq0A_ not modelled 99.0 19 PDB header:ligase Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: thermus thermophilus arginyl-trna synthetase 40 c2g36A_ not modelled 98.4 18 PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase (ec 6.1.1.2)2 (tryptophan-trna ligase)(trprs) (tm0492) from thermotoga maritima at3 2.50 a resolution 41 c1gaxB_ not modelled 98.3 29 PDB header:ligase/rna Chain: B: PDB Molecule:valyl-trna synthetase; PDBTitle: crystal structure of thermus thermophilus valyl-trna2 synthetase complexed with trna(val) and valyl-adenylate3 analogue 42 c1wkbA_ not modelled 98.3 27 PDB header:ligase Chain: A: PDB Molecule:leucyl-trna synthetase; PDBTitle: crystal structure of leucyl-trna synthetase from the2 archaeon pyrococcus horikoshii reveals a novel editing3 domain orientation 43 c1wz2B_ not modelled 98.3 23 PDB header:ligase/rna Chain: B: PDB Molecule:leucyl-trna synthetase; PDBTitle: the crystal structure of leucyl-trna synthetase and trna(leucine)2 complex 44 c2j5bA_ not modelled 98.2 20 PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: structure of the tyrosyl trna synthetase from acanthamoeba2 polyphaga mimivirus complexed with tyrosynol 45 c1obhA_ not modelled 98.1 19 PDB header:synthetase Chain: A: PDB Molecule:leucyl-trna synthetase; PDBTitle: leucyl-trna synthetase from thermus thermophilus complexed2 with a pre-transfer editing substrate analogue in both3 synthetic active site and editing site 46 c1qu2A_ not modelled 98.1 28 PDB header:ligase/rna Chain: A: PDB Molecule:isoleucyl-trna synthetase; PDBTitle: insights into editing from an ile-trna synthetase structure2 with trna(ile) and mupirocin 47 c2cybA_ not modelled 98.1 17 PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of tyrosyl-trna synthetase complexed with2 l-tyrosine from archaeoglobus fulgidus 48 c1ileA_ not modelled 98.0 18 PDB header:aminoacyl-trna synthetase Chain: A: PDB Molecule:isoleucyl-trna synthetase; PDBTitle: isoleucyl-trna synthetase 49 c3focB_ not modelled 98.0 18 PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase from giardia lamblia 50 c2cyaA_ not modelled 97.8 14 PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of tyrosyl-trna synthetase from aeropyrum pernix 51 c3hzrD_ not modelled 97.8 13 PDB header:ligase Chain: D: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase homolog from entamoeba histolytica 52 c3prhB_ not modelled 97.7 14 PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase val144pro mutant from b. subtilis 53 c3p0jD_ not modelled 97.6 17 PDB header:ligase Chain: D: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: leishmania major tyrosyl-trna synthetase in complex with tyrosinol,2 triclinic crystal form 1 54 c2el7A_ not modelled 97.6 14 PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from thermus2 thermophilus 55 c1h3eA_ not modelled 97.5 19 PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: tyrosyl-trna synthetase from thermus thermophilus complexed2 with wild-type trnatyr(gua) and with atp and tyrosinol 56 c3a05A_ not modelled 97.5 19 PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from2 hyperthermophilic archaeon, aeropyrum pernix k1 complex3 with tryptophan 57 c3jxeB_ not modelled 97.3 21 PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of pyrococcus horikoshii tryptophanyl-trna2 synthetase in complex with trpamp 58 c3m5wB_ not modelled 97.3 24 PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from2 campylobacter jejuni 59 d1h3fa1 not modelled 97.3 21 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 60 d1i6la_ not modelled 97.2 18 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 61 c1jiiA_ not modelled 97.2 17 PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of s. aureus tyrrs in complex with sb-219383 62 c2yy5C_ not modelled 97.1 13 PDB header:ligase Chain: C: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from mycoplasma2 pneumoniae 63 c2quiB_ not modelled 97.1 15 PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structures of human tryptophanyl-trna synthetase in2 complex with tryptophanamide and atp 64 c3hv0A_ not modelled 96.9 19 PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase from cryptosporidium parvum 65 c2ip1A_ not modelled 96.8 16 PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure analysis of s. cerevisiae tryptophanyl trna2 synthetase 66 c3n9iA_ not modelled 96.8 16 PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from yersinia pestis2 co92 67 c3i05B_ not modelled 96.8 14 PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: tryptophanyl-trna synthetase from trypanosoma brucei 68 c2janD_ not modelled 96.7 14 PDB header:ligase Chain: D: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: tyrosyl-trna synthetase from mycobacterium tuberculosis in2 unliganded state 69 c1yi8C_ not modelled 96.6 23 PDB header:ligase Chain: C: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl trrna synthetase ii from deinococcus2 radiodurans in complex with l-trp 70 d1jila_ not modelled 96.6 18 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 71 c3sz3A_ not modelled 96.5 14 PDB header:ligase Chain: A: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of tryptophanyl-trna synthetase from vibrio cholerae2 with an endogenous tryptophan 72 c2cycB_ not modelled 96.4 17 PDB header:ligase Chain: B: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of tyrosyl-trna synthetase complexed with l-tyrosine2 from pyrococcus horikoshii 73 c1x8xA_ not modelled 96.4 13 PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: tyrosyl t-rna synthetase from e.coli complexed with tyrosine 74 c2dlcX_ not modelled 96.4 16 PDB header:ligase/trna Chain: X: PDB Molecule:tyrosyl-trna synthetase, cytoplasmic; PDBTitle: crystal structure of the ternary complex of yeast tyrosyl-trna2 synthetase 75 d1n3la_ not modelled 96.1 16 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 76 c1q11A_ not modelled 96.1 17 PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of an active fragment of human tyrosyl-trna2 synthetase with tyrosinol 77 d1r6ta2 not modelled 94.6 13 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 78 d1j1ua_ not modelled 94.5 15 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 79 c1r6uB_ not modelled 93.6 13 PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of an active fragment of human tryptophanyl-trna2 synthetase with cytokine activity 80 d2ts1a_ not modelled 92.9 14 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Nucleotidylyl transferase Family:Class I aminoacyl-tRNA synthetases (RS), catalytic domain 81 c2ts1A_ not modelled 92.9 14 PDB header:ligase (synthetase) Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: structure of tyrosyl-t/rna synthetase refined at 2.3 angstroms2 resolution. interaction of the enzyme with the tyrosyl adenylate3 intermediate 82 c2rkjM_ not modelled 91.6 14 PDB header:ligase/rna Chain: M: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: cocrystal structure of a tyrosyl-trna synthetase splicing2 factor with a group i intron rna 83 c2pidB_ not modelled 84.5 21 PDB header:ligase Chain: B: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: crystal structure of human mitochondrial tyrosyl-trna synthetase in2 complex with an adenylate analog 84 c1q1qA_ not modelled 67.4 10 PDB header:transferase Chain: A: PDB Molecule:sulfotransferase family, cytosolic, 2b, member 1 PDBTitle: crystal structure of human pregnenolone sulfotransferase2 (sult2b1a) in the presence of pap 85 d1aqua_ not modelled 66.4 11 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 86 d2a3ra1 not modelled 65.3 11 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 87 c2gwhA_ not modelled 59.7 14 PDB header:transferase Chain: A: PDB Molecule:sulfotransferase 1c2; PDBTitle: human sulfotranferase sult1c2 in complex with pap and2 pentachlorophenol 88 d1ls6a_ not modelled 59.4 11 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 89 c3u3oA_ not modelled 58.9 11 PDB header:transferase Chain: A: PDB Molecule:sulfotransferase 1a1; PDBTitle: crystal structure of human sult1a1 bound to pap and two 3-cyano-7-2 hydroxycoumarin 90 c3guzB_ not modelled 58.5 27 PDB header:ligase Chain: B: PDB Molecule:pantothenate synthetase; PDBTitle: structural and substrate-binding studies of pantothenate2 synthenate (ps)provide insights into homotropic inhibition3 by pantoate in ps's 91 d3bfxa1 not modelled 56.5 15 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 92 d1xv1a_ not modelled 52.3 12 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 93 d1e5qa2 not modelled 52.1 23 Fold:FwdE/GAPDH domain-like Superfamily:Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family:Homoserine dehydrogenase-like 94 c2jd3B_ not modelled 50.9 19 PDB header:dna binding protein Chain: B: PDB Molecule:stbb protein; PDBTitle: parr from plasmid pb171 95 c2ragB_ not modelled 48.7 31 PDB header:hydrolase Chain: B: PDB Molecule:dipeptidase; PDBTitle: crystal structure of aminohydrolase from caulobacter crescentus 96 c2h8kA_ not modelled 45.1 11 PDB header:transferase Chain: A: PDB Molecule:sult1c3 splice variant d; PDBTitle: human sulfotranferase sult1c3 in complex with pap 97 c2zvpX_ not modelled 44.0 10 PDB header:transferase Chain: X: PDB Molecule:tyrosine-ester sulfotransferase; PDBTitle: crystal structure of mouse cytosolic sulfotransferase msult1d1 complex2 with pap and p-nitrophenol 98 d1jhfa1 not modelled 43.5 13 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:LexA repressor, N-terminal DNA-binding domain 99 d1q20a_ not modelled 41.2 10 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 100 d1fmja_ not modelled 40.6 16 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:PAPS sulfotransferase 101 c1t6zB_ not modelled 40.0 19 PDB header:transferase Chain: B: PDB Molecule:riboflavin kinase/fmn adenylyltransferase; PDBTitle: crystal structure of riboflavin bound tm379 102 c3b40A_ not modelled 36.8 34 PDB header:hydrolase Chain: A: PDB Molecule:probable dipeptidase; PDBTitle: crystal structure of the probable dipeptidase pvdm from2 pseudomonas aeruginosa 103 d1gjja2 not modelled 34.9 11 Fold:LEM/SAP HeH motif Superfamily:LEM domain Family:LEM domain 104 d1ugpb_ not modelled 33.1 14 Fold:SH3-like barrel Superfamily:Electron transport accessory proteins Family:Nitrile hydratase beta chain 105 d1e6va2 not modelled 32.9 45 Fold:Ferredoxin-like Superfamily:Methyl-coenzyme M reductase subunits Family:Methyl-coenzyme M reductase alpha and beta chain N-terminal domain 106 c2i5gB_ not modelled 29.2 14 PDB header:hydrolase Chain: B: PDB Molecule:amidohydrolase; PDBTitle: crystal strcuture of amidohydrolase from pseudomonas2 aeruginosa 107 d1r9oa_ not modelled 26.2 21 Fold:Cytochrome P450 Superfamily:Cytochrome P450 Family:Cytochrome P450 108 c3l4hA_ not modelled 25.9 45 PDB header:protein binding Chain: A: PDB Molecule:e3 ubiquitin-protein ligase hecw1; PDBTitle: helical box domain and second ww domain of the human e3 ubiquitin-2 protein ligase hecw1 109 c3sggA_ not modelled 25.5 16 PDB header:hydrolase Chain: A: PDB Molecule:hypothetical hydrolase; PDBTitle: crystal structure of a hypothetical hydrolase (bt_2193) from2 bacteroides thetaiotaomicron vpi-5482 at 1.25 a resolution 110 d2je8a2 not modelled 25.3 13 Fold:Immunoglobulin-like beta-sandwich Superfamily:beta-Galactosidase/glucuronidase domain Family:beta-Galactosidase/glucuronidase domain 111 c3ebsA_ not modelled 25.3 18 PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome p450 2a6; PDBTitle: human cytochrome p450 2a6 i208s/i300f/g301a/s369g in complex2 with phenacetin 112 c3nd5D_ not modelled 24.0 9 PDB header:transferase Chain: D: PDB Molecule:phosphopantetheine adenylyltransferase; PDBTitle: crystal structure of phosphopantetheine adenylyltransferase (ppat)2 from enterococcus faecalis 113 d1o94c_ not modelled 23.7 10 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 114 c1zd1B_ not modelled 23.5 13 PDB header:transferase Chain: B: PDB Molecule:sulfotransferase 4a1; PDBTitle: human sulfortransferase sult4a1 115 c2oa9B_ not modelled 22.8 18 PDB header:hydrolase Chain: B: PDB Molecule:r.mvai; PDBTitle: restriction endonuclease mvai in the absence of dna 116 c3i3aC_ not modelled 22.4 18 PDB header:transferase Chain: C: PDB Molecule:acyl-[acyl-carrier-protein]--udp-n- PDBTitle: structural basis for the sugar nucleotide and acyl chain2 selectivity of leptospira interrogans lpxa 117 d1vffa1 not modelled 22.1 17 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Family 1 of glycosyl hydrolase 118 d1e6ya2 not modelled 22.0 41 Fold:Ferredoxin-like Superfamily:Methyl-coenzyme M reductase subunits Family:Methyl-coenzyme M reductase alpha and beta chain N-terminal domain 119 c3e27B_ not modelled 21.6 13 PDB header:transferase Chain: B: PDB Molecule:nicotinate (nicotinamide) nucleotide PDBTitle: nicotinic acid mononucleotide (namn) adenylyltransferase2 from bacillus anthracis: product complex 120 d1hbna2 not modelled 21.5 38 Fold:Ferredoxin-like Superfamily:Methyl-coenzyme M reductase subunits Family:Methyl-coenzyme M reductase alpha and beta chain N-terminal domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0