Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Y	P	V	D	L	H	M	H	T	V	A	S	T	H	A	Y	S	T	L	S	D	Y	I	A	Q	A	K	Q	K	G	I	K	L	F	A	I	T	D	H	G	P	D	M	E	D	A	P	H	H	W	H	F	I	N	M	R	I	W	P
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	V	V	D	G	V	G	I	L	R	G	I	E	A	N	I	K	N	V	D	G	E	I	D	C	S	G	K	M	F	D	S	L	D	L	I	I	A	G	F	H	E	P	V	F	A	P	H	D	K	A	T	N	T	Q	A	M	I	A	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	A	S	G	N	V	H	I	I	S	H	P	G	N	P	K	Y	E	I	D	V	K	A	V	A	E	A	A	A	K	H	Q	V	A	L	E	I	N	N	S	S	F	L	H	S	R	K	G	S	E	D	N	C	R	E	V	A	A	A	V
Secondary structure
SS confidence
Disorder																																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	D	A	G	G	W	V	A	L	G	S	D	S	H	T	A	F	T	M	G	E	F	E	E	C	L	K	I	L	D	A	V	D	F	P	P	E	R	I	L	N	V	S	P	R	R	L	L	N	F	L	E	S	R	G	M	A	P	I	A
Secondary structure
SS confidence
Disorder																																																									?			?
Disorder confidence
		.	.	.	.	.
Sequence		E	F	A	D	L
Secondary structure
SS confidence
Disorder			?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1m65 chain A Region: 2 - 245 Aligned: 234 Modelled: 244 Confidence: 100.0% Identity: 100% Fold: 7-stranded beta/alpha barrel Superfamily: PHP domain-like Family: PHP domain Phyre2 PDB 2w9m chain B Region: 2 - 238 Aligned: 226 Modelled: 237 Confidence: 100.0% Identity: 19% PDB header:dna replication Chain: B: PDB Molecule:polymerase x; PDBTitle: structure of family x dna polymerase from deinococcus2 radiodurans Phyre2 PDB 2yz5 chain B Region: 4 - 216 Aligned: 212 Modelled: 213 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:histidinol phosphatase; PDBTitle: histidinol phosphate phosphatase complexed with phosphate Phyre2 PDB 3qy6 chain A Region: 1 - 229 Aligned: 220 Modelled: 229 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase ywqe; PDBTitle: crystal structures of ywqe from bacillus subtilis and cpsb from2 streptococcus pneumoniae, unique metal-dependent tyrosine3 phosphatases Phyre2 PDB 2wje chain A Region: 4 - 229 Aligned: 224 Modelled: 226 Confidence: 100.0% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase cpsb; PDBTitle: crystal structure of the tyrosine phosphatase cps4b from2 steptococcus pneumoniae tigr4. Phyre2 PDB 3dcp chain B Region: 3 - 200 Aligned: 198 Modelled: 198 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:histidinol-phosphatase; PDBTitle: crystal structure of the putative histidinol phosphatase2 hisk from listeria monocytogenes. northeast structural3 genomics consortium target lmr141. Phyre2 PDB 3e0f chain A Region: 4 - 240 Aligned: 203 Modelled: 218 Confidence: 99.9% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:putative metal-dependent phosphoesterase; PDBTitle: crystal structure of a putative metal-dependent phosphoesterase2 (bad_1165) from bifidobacterium adolescentis atcc 15703 at 2.40 a3 resolution Phyre2 PDB 2yb1 chain A Region: 4 - 196 Aligned: 178 Modelled: 185 Confidence: 99.9% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolase; PDBTitle: structure of an amidohydrolase from chromobacterium violaceum (efi2 target efi-500202) with bound mn, amp and phosphate. Phyre2 PDB 2anu chain A domain 1 Region: 2 - 235 Aligned: 192 Modelled: 195 Confidence: 99.9% Identity: 17% Fold: 7-stranded beta/alpha barrel Superfamily: PHP domain-like Family: PHP domain Phyre2 PDB 2anu chain A Region: 2 - 235 Aligned: 192 Modelled: 195 Confidence: 99.9% Identity: 17% PDB header:metal binding protein Chain: A: PDB Molecule:hypothetical protein tm0559; PDBTitle: crystal structure of predicted metal-dependent phosphoesterase (php2 family) (tm0559) from thermotoga maritima at 2.40 a resolution Phyre2 PDB 3e0d chain A Region: 1 - 210 Aligned: 198 Modelled: 210 Confidence: 99.9% Identity: 16% PDB header:transferase/dna Chain: A: PDB Molecule:dna polymerase iii subunit alpha; PDBTitle: insights into the replisome from the crystral structure of2 the ternary complex of the eubacterial dna polymerase iii3 alpha-subunit Phyre2 PDB 3e38 chain A Region: 2 - 200 Aligned: 175 Modelled: 185 Confidence: 99.9% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:two-domain protein containing predicted php-like metal- PDBTitle: crystal structure of a two-domain protein containing predicted php-2 like metal-dependent phosphoesterase (bvu_3505) from bacteroides3 vulgatus atcc 8482 at 2.20 a resolution Phyre2 PDB 2hnh chain A Region: 1 - 211 Aligned: 207 Modelled: 211 Confidence: 99.9% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:dna polymerase iii alpha subunit; PDBTitle: crystal structure of the catalytic alpha subunit of e. coli2 replicative dna polymerase iii Phyre2 PDB 3f2c chain A Region: 3 - 195 Aligned: 176 Modelled: 193 Confidence: 99.8% Identity: 22% PDB header:transferase/dna Chain: A: PDB Molecule:geobacillus kaustophilus dna polc; PDBTitle: dna polymerase polc from geobacillus kaustophilus complex with dna,2 dgtp and mn Phyre2 PDB 1v77 chain A Region: 22 - 232 Aligned: 186 Modelled: 210 Confidence: 98.3% Identity: 14% Fold: 7-stranded beta/alpha barrel Superfamily: PHP domain-like Family: RNase P subunit p30 Phyre2 PDB 1bf6 chain A Region: 3 - 232 Aligned: 222 Modelled: 230 Confidence: 97.6% Identity: 10% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: Phosphotriesterase-like Phyre2 PDB 3rcm chain A Region: 3 - 232 Aligned: 219 Modelled: 230 Confidence: 97.4% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:tatd family hydrolase; PDBTitle: crystal structure of efi target 500140:tatd family hydrolase from2 pseudomonas putida Phyre2 PDB 1yix chain A domain 1 Region: 1 - 232 Aligned: 218 Modelled: 232 Confidence: 97.1% Identity: 11% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: TatD Mg-dependent DNase-like Phyre2 PDB 1xrt chain A domain 2 Region: 3 - 232 Aligned: 218 Modelled: 229 Confidence: 97.1% Identity: 11% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: Hydantoinase (dihydropyrimidinase), catalytic domain Phyre2 PDB 3rys chain A Region: 3 - 237 Aligned: 230 Modelled: 235 Confidence: 97.1% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:adenosine deaminase 1; PDBTitle: the crystal structure of adenine deaminase (aaur1117) from2 arthrobacter aurescens Phyre2 1 d1m65a_ 2 c2w9mB_ 3 c2yz5B_ 4 c3qy6A_ 5 c2wjeA_ 6 c3dcpB_ 7 c3e0fA_ 8 c2yb1A_ 9 d2anua1 10 c2anuA_ 11 c3e0dA_ 12 c3e38A_ 13 c2hnhA_ 14 c3f2cA_ 15 d1v77a_ 16 d1bf6a_ 17 c3rcmA_ 18 d1yixa1 19 d1xrta2 20 c3rysA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1m65a_ 100.0 100 Fold:7-stranded beta/alpha barrel Superfamily:PHP domain-like Family:PHP domain 2 c2w9mB_ 100.0 19 PDB header:dna replication Chain: B: PDB Molecule:polymerase x; PDBTitle: structure of family x dna polymerase from deinococcus2 radiodurans 3 c2yz5B_ 100.0 25 PDB header:hydrolase Chain: B: PDB Molecule:histidinol phosphatase; PDBTitle: histidinol phosphate phosphatase complexed with phosphate 4 c3qy6A_ 100.0 16 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase ywqe; PDBTitle: crystal structures of ywqe from bacillus subtilis and cpsb from2 streptococcus pneumoniae, unique metal-dependent tyrosine3 phosphatases 5 c2wjeA_ 100.0 13 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase cpsb; PDBTitle: crystal structure of the tyrosine phosphatase cps4b from2 steptococcus pneumoniae tigr4. 6 c3dcpB_ 100.0 17 PDB header:hydrolase Chain: B: PDB Molecule:histidinol-phosphatase; PDBTitle: crystal structure of the putative histidinol phosphatase2 hisk from listeria monocytogenes. northeast structural3 genomics consortium target lmr141. 7 c3e0fA_ 99.9 25 PDB header:hydrolase Chain: A: PDB Molecule:putative metal-dependent phosphoesterase; PDBTitle: crystal structure of a putative metal-dependent phosphoesterase2 (bad_1165) from bifidobacterium adolescentis atcc 15703 at 2.40 a3 resolution 8 c2yb1A_ 99.9 26 PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolase; PDBTitle: structure of an amidohydrolase from chromobacterium violaceum (efi2 target efi-500202) with bound mn, amp and phosphate. 9 d2anua1 99.9 17 Fold:7-stranded beta/alpha barrel Superfamily:PHP domain-like Family:PHP domain 10 c2anuA_ 99.9 17 PDB header:metal binding protein Chain: A: PDB Molecule:hypothetical protein tm0559; PDBTitle: crystal structure of predicted metal-dependent phosphoesterase (php2 family) (tm0559) from thermotoga maritima at 2.40 a resolution 11 c3e0dA_ 99.9 16 PDB header:transferase/dna Chain: A: PDB Molecule:dna polymerase iii subunit alpha; PDBTitle: insights into the replisome from the crystral structure of2 the ternary complex of the eubacterial dna polymerase iii3 alpha-subunit 12 c3e38A_ 99.9 17 PDB header:hydrolase Chain: A: PDB Molecule:two-domain protein containing predicted php-like metal- PDBTitle: crystal structure of a two-domain protein containing predicted php-2 like metal-dependent phosphoesterase (bvu_3505) from bacteroides3 vulgatus atcc 8482 at 2.20 a resolution 13 c2hnhA_ 99.9 14 PDB header:transferase Chain: A: PDB Molecule:dna polymerase iii alpha subunit; PDBTitle: crystal structure of the catalytic alpha subunit of e. coli2 replicative dna polymerase iii 14 c3f2cA_ 99.8 22 PDB header:transferase/dna Chain: A: PDB Molecule:geobacillus kaustophilus dna polc; PDBTitle: dna polymerase polc from geobacillus kaustophilus complex with dna,2 dgtp and mn 15 d1v77a_ 98.3 14 Fold:7-stranded beta/alpha barrel Superfamily:PHP domain-like Family:RNase P subunit p30 16 d1bf6a_ 97.6 10 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Phosphotriesterase-like 17 c3rcmA_ 97.4 11 PDB header:hydrolase Chain: A: PDB Molecule:tatd family hydrolase; PDBTitle: crystal structure of efi target 500140:tatd family hydrolase from2 pseudomonas putida 18 d1yixa1 97.1 11 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:TatD Mg-dependent DNase-like 19 d1xrta2 97.1 11 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 20 c3rysA_ 97.1 15 PDB header:hydrolase Chain: A: PDB Molecule:adenosine deaminase 1; PDBTitle: the crystal structure of adenine deaminase (aaur1117) from2 arthrobacter aurescens 21 d1xwya1 not modelled 97.0 12 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:TatD Mg-dependent DNase-like 22 c2xioA_ not modelled 96.9 16 PDB header:hydrolase Chain: A: PDB Molecule:putative deoxyribonuclease tatdn1; PDBTitle: structure of putative deoxyribonuclease tatdn1 isoform a 23 c2y1hA_ not modelled 96.9 15 PDB header:hydrolase Chain: A: PDB Molecule:putative deoxyribonuclease tatdn3; PDBTitle: crystal structure of the human tatd-domain protein 3 (tatdn3) 24 d1zzma1 not modelled 96.8 10 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:TatD Mg-dependent DNase-like 25 c3f4cA_ not modelled 96.7 11 PDB header:hydrolase Chain: A: PDB Molecule:organophosphorus hydrolase; PDBTitle: crystal structure of organophosphorus hydrolase from geobacillus2 stearothermophilus strain 10, with glycerol bound 26 d1j6oa_ not modelled 96.6 10 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:TatD Mg-dependent DNase-like 27 c3rhgA_ not modelled 96.5 12 PDB header:hydrolase Chain: A: PDB Molecule:putative phophotriesterase; PDBTitle: crystal structure of amidohydrolase pmi1525 (target efi-500319) from2 proteus mirabilis hi4320 28 c3ou8A_ not modelled 96.2 12 PDB header:hydrolase Chain: A: PDB Molecule:adenosine deaminase; PDBTitle: the crystal structure of adenosine deaminase from pseudomonas2 aeruginosa 29 c2vc7A_ not modelled 95.9 16 PDB header:hydrolase Chain: A: PDB Molecule:aryldialkylphosphatase; PDBTitle: structural basis for natural lactonase and promiscuous2 phosphotriesterase activities 30 c3ou8B_ not modelled 95.1 11 PDB header:hydrolase Chain: B: PDB Molecule:adenosine deaminase; PDBTitle: the crystal structure of adenosine deaminase from pseudomonas2 aeruginosa 31 d2icsa2 not modelled 95.1 13 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Adenine deaminase-like 32 c3ipwA_ not modelled 95.0 10 PDB header:hydrolase Chain: A: PDB Molecule:hydrolase tatd family protein; PDBTitle: crystal structure of hydrolase tatd family protein from entamoeba2 histolytica 33 d2amxa1 not modelled 94.8 17 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Adenosine/AMP deaminase 34 c3gg7A_ not modelled 94.2 12 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized metalloprotein; PDBTitle: crystal structure of an uncharacterized metalloprotein from2 deinococcus radiodurans 35 c3msrA_ not modelled 94.1 17 PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolases; PDBTitle: the crystal structure of an amidohydrolase from mycoplasma synoviae 36 d1vfla1 not modelled 94.1 13 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Adenosine/AMP deaminase 37 d1i0da_ not modelled 94.1 14 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Phosphotriesterase-like 38 d1onwa2 not modelled 93.8 17 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Isoaspartyl dipeptidase, catalytic domain 39 c2zc1A_ not modelled 93.7 11 PDB header:hydrolase Chain: A: PDB Molecule:phosphotriesterase; PDBTitle: organophosphorus hydrolase from deinococcus radiodurans 40 d1ynya2 not modelled 93.3 8 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 41 c3k2gA_ not modelled 93.2 10 PDB header:resiniferatoxin binding protein Chain: A: PDB Molecule:resiniferatoxin-binding, phosphotriesterase- PDBTitle: crystal structure of a resiniferatoxin-binding protein from2 rhodobacter sphaeroides 42 c1pscA_ not modelled 93.1 13 PDB header:hydrolase Chain: A: PDB Molecule:phosphotriesterase; PDBTitle: phosphotriesterase from pseudomonas diminuta 43 d2f6ka1 not modelled 92.7 8 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:PP1699/LP2961-like 44 d2imra2 not modelled 92.4 20 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:DR0824-like 45 d2i9ua2 not modelled 92.3 14 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:SAH/MTA deaminase-like 46 d1p1ma2 not modelled 91.6 14 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:SAH/MTA deaminase-like 47 c3ij6A_ not modelled 90.7 10 PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized metal-dependent hydrolase; PDBTitle: crystal structure of an uncharacterized metal-dependent2 hydrolase from lactobacillus acidophilus 48 d1k1da2 not modelled 90.7 12 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 49 c3guwB_ not modelled 90.3 11 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein af_1765; PDBTitle: crystal structure of the tatd-like protein (af1765) from2 archaeoglobus fulgidus, northeast structural genomics3 consortium target gr121 50 d1gkra2 not modelled 90.0 12 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 51 c3nqbB_ not modelled 89.8 12 PDB header:hydrolase Chain: B: PDB Molecule:adenine deaminase 2; PDBTitle: crystal structure of adenine deaminase from agrobacterium tumefaciens2 (str. c 58) 52 d2ffia1 not modelled 89.4 16 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:PP1699/LP2961-like 53 d2paja2 not modelled 88.7 11 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:SAH/MTA deaminase-like 54 d2d2ja1 not modelled 87.1 14 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Phosphotriesterase-like 55 c3pnzD_ not modelled 87.1 12 PDB header:hydrolase Chain: D: PDB Molecule:phosphotriesterase family protein; PDBTitle: crystal structure of the lactonase lmo2620 from listeria monocytogenes 56 c2wm1A_ not modelled 86.3 14 PDB header:lyase Chain: A: PDB Molecule:2-amino-3-carboxymuconate-6-semialdehyde PDBTitle: the crystal structure of human alpha-amino-beta-2 carboxymuconate-epsilon-semialdehyde decarboxylase in3 complex with 1,3- dihydroxyacetonephosphate suggests a4 regulatory link between nad synthesis and glycolysis 57 d2fvka2 not modelled 85.9 14 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 58 d2bb0a2 not modelled 85.8 12 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Imidazolonepropionase-like 59 c2gzxB_ not modelled 85.6 9 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative tatd related dnase; PDBTitle: crystal structure of the tatd deoxyribonuclease mw0446 from2 staphylococcus aureus. northeast structural genomics consortium3 target zr237. 60 c3e2vA_ not modelled 84.9 14 PDB header:hydrolase Chain: A: PDB Molecule:3'-5'-exonuclease; PDBTitle: crystal structure of an uncharacterized amidohydrolase from2 saccharomyces cerevisiae 61 d2puza2 not modelled 84.8 14 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Imidazolonepropionase-like 62 d1nfga2 not modelled 82.7 11 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 63 d2q09a2 not modelled 80.1 12 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Imidazolonepropionase-like 64 d2ftwa2 not modelled 79.0 10 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 65 d2uz9a2 not modelled 77.6 15 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:SAH/MTA deaminase-like 66 d1kcxa2 not modelled 77.3 5 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 67 c3cprB_ not modelled 71.9 10 PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthetase; PDBTitle: the crystal structure of corynebacterium glutamicum2 dihydrodipicolinate synthase to 2.2 a resolution 68 c2yxgD_ not modelled 70.1 15 PDB header:lyase Chain: D: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihyrodipicolinate synthase (dapa) 69 c2qahA_ not modelled 69.6 18 PDB header:hydrolase Chain: A: PDB Molecule:2-pyrone-4,6-dicarboxylic acid hydrolase; PDBTitle: crystal structure of the 2-pyrone-4,6-dicarboxylic acid2 hydrolase from sphingomonas paucimobilis 70 c3daqB_ not modelled 65.0 10 PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from methicillin-2 resistant staphylococcus aureus 71 c1xrfA_ not modelled 62.7 12 PDB header:hydrolase Chain: A: PDB Molecule:dihydroorotase; PDBTitle: the crystal structure of a novel, latent dihydroorotase from aquifex2 aeolicus at 1.7 a resolution 72 c3cjpA_ not modelled 61.4 11 PDB header:hydrolase Chain: A: PDB Molecule:predicted amidohydrolase, dihydroorotase family; PDBTitle: crystal structure of an uncharacterized amidohydrolase cac3332 from2 clostridium acetobutylicum 73 c3irsB_ not modelled 60.8 11 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein bb4693; PDBTitle: crystal structure of uncharacterized tim-barrel protein bb4693 from2 bordetella bronchiseptica 74 c2bb0A_ not modelled 57.7 11 PDB header:hydrolase Chain: A: PDB Molecule:imidazolonepropionase; PDBTitle: structure of imidazolonepropionase from bacillus subtilis 75 d2p9ba2 not modelled 54.6 13 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Imidazolonepropionase-like 76 c3lggA_ not modelled 54.4 17 PDB header:hydrolase Chain: A: PDB Molecule:adenosine deaminase cecr1; PDBTitle: crystal structure of human adenosine deaminase growth factor,2 adenosine deaminase type 2 (ada2) complexed with transition state3 analogue, coformycin 77 c1o12B_ not modelled 54.3 24 PDB header:hydrolase Chain: B: PDB Molecule:n-acetylglucosamine-6-phosphate deacetylase; PDBTitle: crystal structure of n-acetylglucosamine-6-phosphate2 deacetylase (tm0814) from thermotoga maritima at 2.5 a3 resolution 78 d1ra0a2 not modelled 52.7 11 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Cytosine deaminase catalytic domain 79 c3nurA_ not modelled 52.6 8 PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolase; PDBTitle: crystal structure of a putative amidohydrolase from staphylococcus2 aureus 80 d1xxxa1 not modelled 51.1 12 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 81 d1yara1 not modelled 51.0 24 Fold:Ntn hydrolase-like Superfamily:N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family:Proteasome subunits 82 d1x92a_ not modelled 50.6 17 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 83 d1iruf_ not modelled 49.0 21 Fold:Ntn hydrolase-like Superfamily:N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family:Proteasome subunits 84 c1iruF_ not modelled 49.0 21 PDB header:hydrolase Chain: F: PDB Molecule:20s proteasome; PDBTitle: crystal structure of the mammalian 20s proteasome at 2.75 a2 resolution 85 d3be7a2 not modelled 48.2 13 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Zn-dependent arginine carboxypeptidase-like 86 c3pnuA_ not modelled 48.1 9 PDB header:hydrolase Chain: A: PDB Molecule:dihydroorotase; PDBTitle: 2.4 angstrom crystal structure of dihydroorotase (pyrc) from2 campylobacter jejuni. 87 c3noeA_ not modelled 45.6 13 PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from pseudomonas2 aeruginosa 88 d1a4ma_ not modelled 45.2 12 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Adenosine/AMP deaminase 89 d1rypb_ not modelled 45.0 25 Fold:Ntn hydrolase-like Superfamily:N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family:Proteasome subunits 90 d1o12a2 not modelled 44.9 13 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:N-acetylglucosamine-6-phosphate deacetylase, NagA, catalytic domain 91 c3hm7A_ not modelled 43.5 7 PDB header:hydrolase Chain: A: PDB Molecule:allantoinase; PDBTitle: crystal structure of allantoinase from bacillus halodurans c-125 92 c3si9B_ not modelled 42.9 11 PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from bartonella2 henselae 93 d1irug_ not modelled 41.9 13 Fold:Ntn hydrolase-like Superfamily:N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family:Proteasome subunits 94 c2xhzC_ not modelled 41.4 25 PDB header:isomerase Chain: C: PDB Molecule:arabinose 5-phosphate isomerase; PDBTitle: probing the active site of the sugar isomerase domain from e. coli2 arabinose-5-phosphate isomerase via x-ray crystallography 95 d1vkya_ not modelled 41.4 18 Fold:QueA-like Superfamily:QueA-like Family:QueA-like 96 d4ubpc2 not modelled 40.2 15 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:alpha-subunit of urease, catalytic domain 97 c2i5gB_ not modelled 39.9 15 PDB header:hydrolase Chain: B: PDB Molecule:amidohydrolase; PDBTitle: crystal strcuture of amidohydrolase from pseudomonas2 aeruginosa 98 d1rypg_ not modelled 39.4 21 Fold:Ntn hydrolase-like Superfamily:N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family:Proteasome subunits 99 c3bdmF_ not modelled 39.4 21 PDB header:hydrolase Chain: F: PDB Molecule:proteasome component c1; PDBTitle: yeast 20s proteasome:glidobactin a-complex 100 c3lu2B_ not modelled 39.1 18 PDB header:hydrolase Chain: B: PDB Molecule:lmo2462 protein; PDBTitle: structure of lmo2462, a listeria monocytogenes amidohydrolase family2 putative dipeptidase 101 d1irua_ not modelled 38.5 21 Fold:Ntn hydrolase-like Superfamily:N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family:Proteasome subunits 102 d1yrra2 not modelled 38.0 14 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:N-acetylglucosamine-6-phosphate deacetylase, NagA, catalytic domain 103 d1hl2a_ not modelled 37.9 11 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 104 c3fxaA_ not modelled 37.8 25 PDB header:sugar binding protein Chain: A: PDB Molecule:sis domain protein; PDBTitle: crystal structure of a putative sugar-phosphate isomerase2 (lmof2365_0531) from listeria monocytogenes str. 4b f2365 at 1.60 a3 resolution 105 d1f6ya_ not modelled 37.7 15 Fold:TIM beta/alpha-barrel Superfamily:Dihydropteroate synthetase-like Family:Methyltetrahydrofolate-utiluzing methyltransferases 106 c3trjC_ not modelled 36.8 19 PDB header:isomerase Chain: C: PDB Molecule:phosphoheptose isomerase; PDBTitle: structure of a phosphoheptose isomerase from francisella tularensis 107 d2q02a1 not modelled 36.4 10 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:IolI-like 108 d1irud_ not modelled 35.9 24 Fold:Ntn hydrolase-like Superfamily:N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family:Proteasome subunits 109 c3h4pB_ not modelled 35.1 24 PDB header:hydrolase Chain: B: PDB Molecule:proteasome subunit alpha; PDBTitle: proteasome 20s core particle from methanocaldococcus2 jannaschii 110 d1un7a2 not modelled 34.7 19 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:N-acetylglucosamine-6-phosphate deacetylase, NagA, catalytic domain 111 d1iruc_ not modelled 34.2 18 Fold:Ntn hydrolase-like Superfamily:N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family:Proteasome subunits 112 c1gkrA_ not modelled 34.0 13 PDB header:hydrolase Chain: A: PDB Molecule:non-atp dependent l-selective hydantoinase; PDBTitle: l-hydantoinase (dihydropyrimidinase) from arthrobacter2 aurescens 113 d1rypf_ not modelled 33.5 14 Fold:Ntn hydrolase-like Superfamily:N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family:Proteasome subunits 114 d1rypd_ not modelled 33.1 14 Fold:Ntn hydrolase-like Superfamily:N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family:Proteasome subunits 115 c2q09A_ not modelled 32.9 12 PDB header:hydrolase Chain: A: PDB Molecule:imidazolonepropionase; PDBTitle: crystal structure of imidazolonepropionase from environmental sample2 with bound inhibitor 3-(2,5-dioxo-imidazolidin-4-yl)-propionic acid 116 d1gkpa2 not modelled 32.6 10 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 117 c2vr2A_ not modelled 32.3 10 PDB header:hydrolase Chain: A: PDB Molecule:dihydropyrimidinase; PDBTitle: human dihydropyrimidinase 118 d1irue_ not modelled 32.2 18 Fold:Ntn hydrolase-like Superfamily:N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family:Proteasome subunits 119 d2bz1a1 not modelled 31.7 19 Fold:RibA-like Superfamily:RibA-like Family:RibA-like 120 c3bd0D_ not modelled 31.5 12 PDB header:peptide binding protein Chain: D: PDB Molecule:protein memo1; PDBTitle: crystal structure of memo, form ii

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0