Secondary structure and disorder prediction

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Sequence		M	A	K	T	A	A	A	L	H	I	L	V	K	E	E	K	L	A	L	D	L	L	E	Q	I	K	N	G	A	D	F	G	K	L	A	K	K	H	S	I	C	P	S	G	K	R	G	G	D	L	G	E	F	R	Q	G	Q	M	V	P
Secondary structure
SS confidence
Disorder		?	?	?																								?	?	?	?									?	?	?	?	?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.
Sequence		A	F	D	K	V	V	F	S	C	P	V	L	E	P	T	G	P	L	H	T	Q	F	G	Y	H	I	I	K	V	L	Y	R	N
Secondary structure
SS confidence
Disorder													?	?																	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1jns chain A Region: 2 - 93 Aligned: 92 Modelled: 92 Confidence: 100.0% Identity: 100% Fold: FKBP-like Superfamily: FKBP-like Family: FKBP immunophilin/proline isomerase Phyre2 PDB 2rqs chain A Region: 1 - 90 Aligned: 90 Modelled: 90 Confidence: 99.9% Identity: 47% PDB header:isomerase Chain: A: PDB Molecule:parvulin-like peptidyl-prolyl isomerase; PDBTitle: 3d structure of pin from the psychrophilic archeon cenarcheaum2 symbiosum (cspin) Phyre2 PDB 1eq3 chain A Region: 3 - 92 Aligned: 89 Modelled: 90 Confidence: 99.9% Identity: 35% Fold: FKBP-like Superfamily: FKBP-like Family: FKBP immunophilin/proline isomerase Phyre2 PDB 1zk6 chain A Region: 4 - 92 Aligned: 89 Modelled: 89 Confidence: 99.9% Identity: 42% PDB header:isomerase Chain: A: PDB Molecule:foldase protein prsa; PDBTitle: nmr solution structure of b. subtilis prsa ppiase Phyre2 PDB 3gpk chain A Region: 2 - 92 Aligned: 91 Modelled: 91 Confidence: 99.9% Identity: 23% PDB header:isomerase Chain: A: PDB Molecule:ppic-type peptidyl-prolyl cis-trans isomerase; PDBTitle: crystal structure of ppic-type peptidyl-prolyl cis-trans isomerase2 domain at 1.55a resolution. Phyre2 PDB 1pin chain A domain 2 Region: 2 - 91 Aligned: 90 Modelled: 90 Confidence: 99.9% Identity: 41% Fold: FKBP-like Superfamily: FKBP-like Family: FKBP immunophilin/proline isomerase Phyre2 PDB 2pv2 chain A domain 1 Region: 4 - 92 Aligned: 89 Modelled: 89 Confidence: 99.9% Identity: 34% Fold: FKBP-like Superfamily: FKBP-like Family: FKBP immunophilin/proline isomerase Phyre2 PDB 1m5y chain A domain 3 Region: 3 - 92 Aligned: 90 Modelled: 90 Confidence: 99.9% Identity: 33% Fold: FKBP-like Superfamily: FKBP-like Family: FKBP immunophilin/proline isomerase Phyre2 PDB 2jzv chain A Region: 2 - 91 Aligned: 90 Modelled: 90 Confidence: 99.9% Identity: 33% PDB header:isomerase Chain: A: PDB Molecule:foldase protein prsa; PDBTitle: solution structure of s. aureus prsa-ppiase Phyre2 PDB 1f8a chain B Region: 1 - 91 Aligned: 91 Modelled: 91 Confidence: 99.9% Identity: 36% PDB header:isomerase Chain: B: PDB Molecule:peptidyl-prolyl cis-trans isomerase nima- PDBTitle: structural basis for the phosphoserine-proline recognition2 by group iv ww domains Phyre2 PDB 1yw5 chain A Region: 2 - 90 Aligned: 89 Modelled: 89 Confidence: 99.9% Identity: 36% PDB header:isomerase Chain: A: PDB Molecule:peptidyl prolyl cis/trans isomerase; PDBTitle: peptidyl-prolyl isomerase ess1 from candida albicans Phyre2 PDB 1j6y chain A Region: 2 - 90 Aligned: 89 Modelled: 89 Confidence: 99.9% Identity: 39% Fold: FKBP-like Superfamily: FKBP-like Family: FKBP immunophilin/proline isomerase Phyre2 PDB 2kgj chain A Region: 2 - 92 Aligned: 90 Modelled: 91 Confidence: 99.9% Identity: 22% PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase d; PDBTitle: solution structure of parvulin domain of ppid from e.coli Phyre2 PDB 1m5y chain B Region: 2 - 92 Aligned: 91 Modelled: 91 Confidence: 99.8% Identity: 31% PDB header:isomerase, cell cycle Chain: B: PDB Molecule:survival protein sura; PDBTitle: crystallographic structure of sura, a molecular chaperone2 that facilitates outer membrane porin folding Phyre2 PDB 2pv3 chain B Region: 2 - 93 Aligned: 92 Modelled: 92 Confidence: 99.7% Identity: 26% PDB header:isomerase Chain: B: PDB Molecule:chaperone sura; PDBTitle: crystallographic structure of sura fragment lacking the second2 peptidyl-prolyl isomerase domain complexed with peptide nftlkfwdifrk Phyre2 PDB 3nrk chain A Region: 2 - 92 Aligned: 91 Modelled: 91 Confidence: 99.7% Identity: 10% PDB header:unknown function Chain: A: PDB Molecule:lic12922; PDBTitle: the crystal structure of the leptospiral hypothetical protein lic12922 Phyre2 PDB 3rfw chain A Region: 2 - 92 Aligned: 91 Modelled: 91 Confidence: 99.7% Identity: 40% PDB header:chaperone Chain: A: PDB Molecule:cell-binding factor 2; PDBTitle: the virulence factor peb4 and the periplasmic protein cj1289 are two2 structurally-related sura-like chaperones in the human pathogen3 campylobacter jejuni Phyre2 PDB 3rgc chain B Region: 1 - 92 Aligned: 75 Modelled: 75 Confidence: 99.2% Identity: 12% PDB header:chaperone Chain: B: PDB Molecule:possible periplasmic protein; PDBTitle: the virulence factor peb4 and the periplasmic protein cj1289 are two2 structurally related sura-like chaperones in the human pathogen3 campylobacter jejuni Phyre2 PDB 3prd chain A Region: 30 - 73 Aligned: 44 Modelled: 44 Confidence: 31.8% Identity: 30% PDB header:chaperone, isomerase Chain: A: PDB Molecule:fkbp-type peptidyl-prolyl cis-trans isomerase; PDBTitle: structural analysis of protein folding by the methanococcus jannaschii2 chaperone fkbp26 Phyre2 PDB 1vz0 chain A domain 1 Region: 16 - 68 Aligned: 49 Modelled: 53 Confidence: 30.7% Identity: 14% Fold: DNA/RNA-binding 3-helical bundle Superfamily: KorB DNA-binding domain-like Family: KorB DNA-binding domain-like Phyre2 1 d1jnsa_ 2 c2rqsA_ 3 d1eq3a_ 4 c1zk6A_ 5 c3gpkA_ 6 d1pina2 7 d2pv2a1 8 d1m5ya3 9 c2jzvA_ 10 c1f8aB_ 11 c1yw5A_ 12 d1j6ya_ 13 c2kgjA_ 14 c1m5yB_ 15 c2pv3B_ 16 c3nrkA_ 17 c3rfwA_ 18 c3rgcB_ 19 c3prdA_ 20 d1vz0a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1jnsa_ 100.0 100 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 2 c2rqsA_ 99.9 47 PDB header:isomerase Chain: A: PDB Molecule:parvulin-like peptidyl-prolyl isomerase; PDBTitle: 3d structure of pin from the psychrophilic archeon cenarcheaum2 symbiosum (cspin) 3 d1eq3a_ 99.9 35 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 4 c1zk6A_ 99.9 42 PDB header:isomerase Chain: A: PDB Molecule:foldase protein prsa; PDBTitle: nmr solution structure of b. subtilis prsa ppiase 5 c3gpkA_ 99.9 23 PDB header:isomerase Chain: A: PDB Molecule:ppic-type peptidyl-prolyl cis-trans isomerase; PDBTitle: crystal structure of ppic-type peptidyl-prolyl cis-trans isomerase2 domain at 1.55a resolution. 6 d1pina2 99.9 41 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 7 d2pv2a1 99.9 34 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 8 d1m5ya3 99.9 33 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 9 c2jzvA_ 99.9 33 PDB header:isomerase Chain: A: PDB Molecule:foldase protein prsa; PDBTitle: solution structure of s. aureus prsa-ppiase 10 c1f8aB_ 99.9 36 PDB header:isomerase Chain: B: PDB Molecule:peptidyl-prolyl cis-trans isomerase nima- PDBTitle: structural basis for the phosphoserine-proline recognition2 by group iv ww domains 11 c1yw5A_ 99.9 36 PDB header:isomerase Chain: A: PDB Molecule:peptidyl prolyl cis/trans isomerase; PDBTitle: peptidyl-prolyl isomerase ess1 from candida albicans 12 d1j6ya_ 99.9 39 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 13 c2kgjA_ 99.9 22 PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase d; PDBTitle: solution structure of parvulin domain of ppid from e.coli 14 c1m5yB_ 99.8 31 PDB header:isomerase, cell cycle Chain: B: PDB Molecule:survival protein sura; PDBTitle: crystallographic structure of sura, a molecular chaperone2 that facilitates outer membrane porin folding 15 c2pv3B_ 99.7 26 PDB header:isomerase Chain: B: PDB Molecule:chaperone sura; PDBTitle: crystallographic structure of sura fragment lacking the second2 peptidyl-prolyl isomerase domain complexed with peptide nftlkfwdifrk 16 c3nrkA_ 99.7 10 PDB header:unknown function Chain: A: PDB Molecule:lic12922; PDBTitle: the crystal structure of the leptospiral hypothetical protein lic12922 17 c3rfwA_ 99.7 40 PDB header:chaperone Chain: A: PDB Molecule:cell-binding factor 2; PDBTitle: the virulence factor peb4 and the periplasmic protein cj1289 are two2 structurally-related sura-like chaperones in the human pathogen3 campylobacter jejuni 18 c3rgcB_ 99.2 12 PDB header:chaperone Chain: B: PDB Molecule:possible periplasmic protein; PDBTitle: the virulence factor peb4 and the periplasmic protein cj1289 are two2 structurally related sura-like chaperones in the human pathogen3 campylobacter jejuni 19 c3prdA_ 31.8 30 PDB header:chaperone, isomerase Chain: A: PDB Molecule:fkbp-type peptidyl-prolyl cis-trans isomerase; PDBTitle: structural analysis of protein folding by the methanococcus jannaschii2 chaperone fkbp26 20 d1vz0a1 30.7 14 Fold:DNA/RNA-binding 3-helical bundle Superfamily:KorB DNA-binding domain-like Family:KorB DNA-binding domain-like 21 d1zata2 not modelled 27.2 13 Fold:L,D-transpeptidase pre-catalytic domain-like Superfamily:L,D-transpeptidase pre-catalytic domain-like Family:L,D-transpeptidase pre-catalytic domain-like 22 c2elhA_ not modelled 22.0 21 PDB header:dna binding protein Chain: A: PDB Molecule:cg11849-pa; PDBTitle: solution structure of the cenp-b n-terminal dna-binding2 domain of fruit fly distal antenna cg11849-pa 23 d2coba1 not modelled 17.9 11 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Psq domain 24 c1r71B_ not modelled 16.2 13 PDB header:transcription/dna Chain: B: PDB Molecule:transcriptional repressor protein korb; PDBTitle: crystal structure of the dna binding domain of korb in2 complex with the operator dna 25 d1dwka1 not modelled 15.7 14 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:Cyanase N-terminal domain 26 d1q1ca2 not modelled 15.3 11 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 27 d1r71a_ not modelled 14.3 13 Fold:DNA/RNA-binding 3-helical bundle Superfamily:KorB DNA-binding domain-like Family:KorB DNA-binding domain-like 28 c2iv1J_ not modelled 13.7 14 PDB header:lyase Chain: J: PDB Molecule:cyanate hydratase; PDBTitle: site directed mutagenesis of key residues involved in the2 catalytic mechanism of cyanase 29 d1y0ua_ not modelled 12.4 14 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:ArsR-like transcriptional regulators 30 c1q6uA_ not modelled 12.3 12 PDB header:isomerase Chain: A: PDB Molecule:fkbp-type peptidyl-prolyl cis-trans isomerase fkpa; PDBTitle: crystal structure of fkpa from escherichia coli 31 d1q6ha_ not modelled 11.9 12 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 32 c1m98A_ not modelled 11.5 15 PDB header:unknown function Chain: A: PDB Molecule:orange carotenoid protein; PDBTitle: crystal structure of orange carotenoid protein 33 c2phcB_ not modelled 11.5 27 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein ph0987; PDBTitle: crystal structure of conserved uncharacterized protein ph0987 from2 pyrococcus horikoshii 34 d1kt1a3 not modelled 11.4 20 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 35 d2ppna1 not modelled 11.3 9 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 36 c3mmlD_ not modelled 11.2 27 PDB header:hydrolase Chain: D: PDB Molecule:allophanate hydrolase subunit 1; PDBTitle: allophanate hydrolase complex from mycobacterium smegmatis, msmeg0435-2 msmeg0436 37 d1kt0a3 not modelled 10.7 17 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 38 c2vcdA_ not modelled 10.6 17 PDB header:isomerase Chain: A: PDB Molecule:outer membrane protein mip; PDBTitle: solution structure of the fkbp-domain of legionella2 pneumophila mip in complex with rapamycin 39 d1ix5a_ not modelled 10.2 18 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 40 c2lgoA_ not modelled 9.9 13 PDB header:isomerase Chain: A: PDB Molecule:fkbp; PDBTitle: solution nmr structure of a fkbp-type peptidyl-prolyl cis-trans2 isomerase from giardia lamblia, seattle structural genomics center3 for infectious disease target gilaa.00840.a 41 c2zp2B_ not modelled 9.8 36 PDB header:transferase inhibitor Chain: B: PDB Molecule:kinase a inhibitor; PDBTitle: c-terminal domain of kipi from bacillus subtilis 42 d1jvwa_ not modelled 9.6 12 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 43 d1yata_ not modelled 9.2 19 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 44 c3pr9A_ not modelled 9.2 30 PDB header:chaperone Chain: A: PDB Molecule:fkbp-type peptidyl-prolyl cis-trans isomerase; PDBTitle: structural analysis of protein folding by the methanococcus jannaschii2 chaperone fkbp26 45 d1fd9a_ not modelled 9.1 17 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 46 c3bmbB_ not modelled 9.0 12 PDB header:rna binding protein Chain: B: PDB Molecule:regulator of nucleoside diphosphate kinase; PDBTitle: crystal structure of a new rna polymerase interacting2 protein 47 c3o5fA_ not modelled 8.8 22 PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase fkbp5; PDBTitle: fk1 domain of fkbp51, crystal form vii 48 c3dnlB_ not modelled 8.8 23 PDB header:viral protein Chain: B: PDB Molecule:hiv-1 envelope glycoprotein gp120; PDBTitle: molecular structure for the hiv-1 gp120 trimer in the b12-2 bound state 49 d2phcb1 not modelled 8.5 27 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:PH0987 C-terminal domain-like 50 c3oe2A_ not modelled 8.4 13 PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase; PDBTitle: 1.6 a crystal structure of peptidyl-prolyl cis-trans isomerase ppiase2 from pseudomonas syringae pv. tomato str. dc3000 (pspto dc3000) 51 d1nera_ not modelled 8.2 14 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:Phage repressors 52 c3hefB_ not modelled 7.9 22 PDB header:viral protein Chain: B: PDB Molecule:gene 1 protein; PDBTitle: crystal structure of the bacteriophage sf6 terminase small2 subunit 53 c2pbcD_ not modelled 7.9 19 PDB header:isomerase Chain: D: PDB Molecule:fk506-binding protein 2; PDBTitle: fk506-binding protein 2 54 d1kt0a2 not modelled 7.9 22 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 55 d1c9ha_ not modelled 7.9 6 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 56 c3bd1B_ not modelled 7.6 10 PDB header:transcription Chain: B: PDB Molecule:cro protein; PDBTitle: structure of the cro protein from putative prophage element xfaso 1 in2 xylella fastidiosa strain ann-1 57 d1y7ma2 not modelled 7.4 20 Fold:LysM domain Superfamily:LysM domain Family:LysM domain 58 d1q1ca1 not modelled 7.1 19 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 59 d1e0ga_ not modelled 7.1 24 Fold:LysM domain Superfamily:LysM domain Family:LysM domain 60 d1wfwa_ not modelled 7.0 11 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 61 c2kfwA_ not modelled 7.0 9 PDB header:isomerase Chain: A: PDB Molecule:fkbp-type peptidyl-prolyl cis-trans isomerase PDBTitle: solution structure of full-length slyd from e.coli 62 d2akja1 not modelled 6.9 3 Fold:Ferredoxin-like Superfamily:Nitrite/Sulfite reductase N-terminal domain-like Family:Duplicated SiR/NiR-like domains 1 and 3 63 c2pn0D_ not modelled 6.4 6 PDB header:transcription Chain: D: PDB Molecule:prokaryotic transcription elongation factor PDBTitle: prokaryotic transcription elongation factor grea/greb from2 nitrosomonas europaea 64 d2nxya1 not modelled 6.4 23 Fold:gp120 core Superfamily:gp120 core Family:gp120 core 65 d1yymg1 not modelled 5.9 23 Fold:gp120 core Superfamily:gp120 core Family:gp120 core 66 d1r9ha_ not modelled 5.8 19 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 67 d2b4cg1 not modelled 5.5 23 Fold:gp120 core Superfamily:gp120 core Family:gp120 core 68 d1bw6a_ not modelled 5.5 18 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Centromere-binding 69 d1pbka_ not modelled 5.3 13 Fold:FKBP-like Superfamily:FKBP-like Family:FKBP immunophilin/proline isomerase 70 d1w5sa1 not modelled 5.3 9 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Helicase DNA-binding domain 71 c2jwxA_ not modelled 5.2 19 PDB header:apoptosis, isomerase Chain: A: PDB Molecule:fk506-binding protein 8 variant; PDBTitle: solution structure of the n-terminal domain of human fkbp382 (fkbp38ntd)

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0