Email l.a.kelley@imperial.ac.uk Description P0A884 Date Thu Jan 5 11:07:10 GMT 2012 Unique Job ID 9d2bc356928fdd43

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2oipE_ 100.0 51 PDB header:transferase, oxidoreductase Chain: E: PDB Molecule:chain a, crystal structure of dhfr; PDBTitle: crystal structure of the s290g active site mutant of ts-2 dhfr from cryptosporidium hominis 2 d1qzfa2 100.0 51 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 3 d1j3kc_ 100.0 48 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 4 c3jsuA_ 100.0 48 PDB header:oxidoreductase, transferase Chain: A: PDB Molecule:dihydrofolate reductase-thymidylate synthase; PDBTitle: quadruple mutant(n51i+c59r+s108n+i164l) plasmodium falciparum2 dihydrofolate reductase-thymidylate synthase(pfdhfr-ts) complexed3 with qn254, nadph, and dump 5 d1tswa_ 100.0 60 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 6 c3k2hA_ 100.0 49 PDB header:transferase Chain: A: PDB Molecule:dihydrofolate reductase/thymidylate synthase; PDBTitle: co-crystal structure of dihydrofolate reductase/thymidylate synthase2 from babesia bovis with dump, pemetrexed and nadp 7 d2g8oa1 100.0 100 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 8 c3qj7D_ 100.0 66 PDB header:transferase Chain: D: PDB Molecule:thymidylate synthase; PDBTitle: crystal structure of the mycobacterium tuberculosis thymidylate2 synthase (thya) bound to dump 9 c3clbA_ 100.0 51 PDB header:oxidoreductase, transferase Chain: A: PDB Molecule:dhfr-ts; PDBTitle: structure of bifunctional tcdhfr-ts in complex with tmq 10 d1hvya_ 100.0 56 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 11 d1seja2 100.0 51 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 12 c2aazG_ 100.0 49 PDB header:transferase Chain: G: PDB Molecule:thymidylate synthase; PDBTitle: cryptococcus neoformans thymidylate synthase complexed with2 substrate and an antifolate 13 d1f28a_ 100.0 49 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 14 d2tsra_ 100.0 55 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 15 d1bkpa_ 100.0 37 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 16 d1tisa_ 100.0 50 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 17 c1hw3A_ 100.0 56 PDB header:transferase Chain: A: PDB Molecule:thymidylate synthase; PDBTitle: structure of human thymidylate synthase suggests advantages of2 chemotherapy with noncompetitive inhibitors 18 c1hw4A_ 100.0 56 PDB header:transferase Chain: A: PDB Molecule:thymidylate synthase; PDBTitle: structure of thymidylate synthase suggests advantages of chemotherapy2 with noncompetitive inhibitors 19 c3ix6B_ 100.0 66 PDB header:transferase Chain: B: PDB Molecule:thymidylate synthase; PDBTitle: crystal structure of thymidylate synthase thya from brucella2 melitensis 20 c3kgbA_ 100.0 50 PDB header:transferase Chain: A: PDB Molecule:thymidylate synthase 1/2; PDBTitle: crystal structure of thymidylate synthase 1/2 from encephalitozoon2 cuniculi at 2.2 a resolution 21 d1b5ea_ not modelled 100.0 24 Fold:Thymidylate synthase/dCMP hydroxymethylase Superfamily:Thymidylate synthase/dCMP hydroxymethylase Family:Thymidylate synthase/dCMP hydroxymethylase 22 c2vsvB_ not modelled 42.0 9 PDB header:protein-binding Chain: B: PDB Molecule:rhophilin-2; PDBTitle: crystal structure of the pdz domain of human rhophilin-2 23 c2q3gA_ not modelled 35.1 22 PDB header:structural genomics Chain: A: PDB Molecule:pdz and lim domain protein 7; PDBTitle: structure of the pdz domain of human pdlim7 bound to a c-2 terminal extension from human beta-tropomyosin 24 c3o46A_ not modelled 28.1 13 PDB header:protein binding Chain: A: PDB Molecule:maguk p55 subfamily member 7; PDBTitle: crystal structure of the pdz domain of mpp7 25 d1r6ja_ not modelled 28.0 13 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 26 c1r6jA_ not modelled 28.0 13 PDB header:membrane protein Chain: A: PDB Molecule:syntenin 1; PDBTitle: ultrahigh resolution crystal structure of syntenin pdz2 27 c1nteA_ not modelled 28.0 13 PDB header:signaling protein Chain: A: PDB Molecule:syntenin 1; PDBTitle: crystal structure analysis of the second pdz domain of2 syntenin 28 c3diwB_ not modelled 27.5 19 PDB header:signaling protein/cell adhesion Chain: B: PDB Molecule:tax1-binding protein 3; PDBTitle: c-terminal beta-catenin bound tip-1 structure 29 c2jikB_ not modelled 27.2 16 PDB header:membrane protein Chain: B: PDB Molecule:synaptojanin-2 binding protein; PDBTitle: crystal structure of pdz domain of synaptojanin-2 binding2 protein 30 d1ueza_ not modelled 26.2 16 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 31 c2eeiA_ not modelled 25.9 6 PDB header:metal binding protein Chain: A: PDB Molecule:pdz domain-containing protein 1; PDBTitle: solution structure of second pdz domain of pdz domain2 containing protein 1 32 d1w9ea1 not modelled 25.8 20 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 33 d1wi2a_ not modelled 24.4 18 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 34 c3khfA_ not modelled 24.4 14 PDB header:transferase Chain: A: PDB Molecule:microtubule-associated serine/threonine-protein PDBTitle: the crystal structure of the pdz domain of human microtubule2 associated serine/threonine kinase 3 (mast3) 35 d1tp5a1 not modelled 23.3 19 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 36 d1fc6a3 not modelled 23.1 14 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:Tail specific protease PDZ domain 37 d1vaea_ not modelled 22.8 9 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 38 c2d8iA_ not modelled 21.4 16 PDB header:immune system, signaling protein Chain: A: PDB Molecule:t-cell lymphoma invasion and metastasis 1 PDBTitle: solution structure of the pdz domain of t-cell lymphoma2 invasion and metastasis 1 varian 39 c2dkrA_ not modelled 20.1 18 PDB header:protein transport Chain: A: PDB Molecule:lin-7 homolog b; PDBTitle: solution structure of the pdz domain from human lin-72 homolog b 40 c2jxoA_ not modelled 19.3 11 PDB header:protein binding Chain: A: PDB Molecule:ezrin-radixin-moesin-binding phosphoprotein 50; PDBTitle: structure of the second pdz domain of nherf-1 41 c2kv8A_ not modelled 18.4 13 PDB header:signaling protein Chain: A: PDB Molecule:regulator of g-protein signaling 12; PDBTitle: solution structure ofrgs12 pdz domain 42 c2fneB_ not modelled 17.0 15 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:multiple pdz domain protein; PDBTitle: the crystal structure of the 13th pdz domain of mpdz 43 c2d90A_ not modelled 16.8 17 PDB header:protein binding Chain: A: PDB Molecule:pdz domain containing protein 1; PDBTitle: solution structure of the third pdz domain of pdz domain2 containing protein 1 44 d1kwaa_ not modelled 15.0 16 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 45 d1y7na1 not modelled 14.7 14 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 46 c3shuB_ not modelled 14.4 22 PDB header:cell adhesion Chain: B: PDB Molecule:tight junction protein zo-1; PDBTitle: crystal structure of zo-1 pdz3 47 c2ejyA_ not modelled 14.4 19 PDB header:membrane protein Chain: A: PDB Molecule:55 kda erythrocyte membrane protein; PDBTitle: solution structure of the p55 pdz t85c domain complexed2 with the glycophorin c f127c peptide 48 d1wi4a1 not modelled 13.9 13 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 49 c2e7kA_ not modelled 13.9 22 PDB header:membrane protein Chain: A: PDB Molecule:maguk p55 subfamily member 2; PDBTitle: solution structure of the pdz domain from human maguk p552 subfamily member 2 50 d1p1da2 not modelled 13.3 27 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 51 d1t2ma1 not modelled 13.3 15 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 52 d1nowa1 not modelled 13.3 23 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain 53 c1w9qB_ not modelled 13.1 12 PDB header:cell adhesion Chain: B: PDB Molecule:syntenin 1; PDBTitle: crystal structure of the pdz tandem of human syntenin in2 complex with tnefaf peptide 54 d1ihja_ not modelled 12.5 16 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 55 c2kjdA_ not modelled 11.8 11 PDB header:signaling protein Chain: A: PDB Molecule:sodium/hydrogen exchange regulatory cofactor nhe- PDBTitle: solution structure of extended pdz2 domain from nherf1 (150-2 270) 56 c3qglD_ not modelled 11.8 11 PDB header:protein binding Chain: D: PDB Molecule:sorting nexin-27; PDBTitle: crystal structure of pdz domain of sorting nexin 27 (snx27) in complex2 with the eseskv peptide corresponding to the c-terminal tail of girk3 57 d1uepa_ not modelled 11.6 18 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 58 c2v90E_ not modelled 11.5 8 PDB header:protein-binding Chain: E: PDB Molecule:pdz domain-containing protein 3; PDBTitle: crystal structure of the 3rd pdz domain of intestine- and2 kidney-enriched pdz domain ikepp (pdzd3) 59 c2d92A_ not modelled 11.2 24 PDB header:protein binding Chain: A: PDB Molecule:inad-like protein; PDBTitle: solution structure of the fifth pdz domain of inad-like2 protein 60 c2iwnA_ not modelled 11.1 18 PDB header:signaling protein Chain: A: PDB Molecule:multiple pdz domain protein; PDBTitle: 3rd pdz domain of multiple pdz domain protein mpdz (casp2 target) 61 c2z17A_ not modelled 11.0 14 PDB header:protein binding Chain: A: PDB Molecule:pleckstrin homology sec7 and coiled-coil domains- PDBTitle: crystal sturcture of pdz domain from human pleckstrin2 homology, sec7 62 c3l4fD_ not modelled 10.8 17 PDB header:signaling protein/protein binding Chain: D: PDB Molecule:sh3 and multiple ankyrin repeat domains protein PDBTitle: crystal structure of betapix coiled-coil domain and shank2 pdz complex 63 c1u3bA_ not modelled 10.4 14 PDB header:protein transport Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding, PDBTitle: auto-inhibition mechanism of x11s/mints family scaffold2 proteins revealed by the closed conformation of the tandem3 pdz domains 64 c2eehA_ not modelled 10.2 27 PDB header:metal binding protein Chain: A: PDB Molecule:pdz domain-containing protein 7; PDBTitle: solution structure of first pdz domain of pdz domain2 containing protein 7 65 d1uita_ not modelled 10.2 27 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 66 c2gzvA_ not modelled 10.1 7 PDB header:signaling protein Chain: A: PDB Molecule:prkca-binding protein; PDBTitle: the cystal structure of the pdz domain of human pick1 (casp target) 67 d2byga1 not modelled 10.0 24 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 68 c2jilA_ not modelled 9.9 14 PDB header:membrane protein Chain: A: PDB Molecule:glutamate receptor interacting protein-1; PDBTitle: crystal structure of 2nd pdz domain of glutamate receptor2 interacting protein-1 (grip1) 69 c2egkC_ not modelled 9.9 13 PDB header:protein binding Chain: C: PDB Molecule:general receptor for phosphoinositides 1- PDBTitle: crystal structure of tamalin pdz-intrinsic ligand fusion2 protein 70 d1jaka1 not modelled 9.8 19 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain 71 d1wh1a_ not modelled 9.7 18 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 72 d2fcfa1 not modelled 9.7 18 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 73 d2o7ta1 not modelled 9.6 22 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Tetracyclin repressor-like, N-terminal domain 74 c3qikA_ not modelled 9.5 14 PDB header:hydrolase regulator Chain: A: PDB Molecule:phosphatidylinositol 3,4,5-trisphosphate-dependent rac PDBTitle: crystal structure of the first pdz domain of prex1 75 d1jt6a1 not modelled 9.5 8 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Tetracyclin repressor-like, N-terminal domain 76 c3m4rA_ not modelled 9.5 14 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: structure of the n-terminal class ii aldolase domain of a conserved2 protein from thermoplasma acidophilum 77 c3rcnA_ not modelled 9.4 13 PDB header:hydrolase Chain: A: PDB Molecule:beta-n-acetylhexosaminidase; PDBTitle: crystal structure of beta-n-acetylhexosaminidase from arthrobacter2 aurescens 78 d1lcya1 not modelled 9.4 19 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:HtrA-like serine proteases 79 d1be9a_ not modelled 9.3 19 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 80 d1q3oa_ not modelled 9.3 16 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 81 d1ky9b2 not modelled 9.1 22 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:HtrA-like serine proteases 82 d2f5ya1 not modelled 9.0 14 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 83 c2ka9A_ not modelled 8.9 14 PDB header:cell adhesion Chain: A: PDB Molecule:disks large homolog 4; PDBTitle: solution structure of psd-95 pdz12 complexed with cypin2 peptide 84 d1pi1a_ not modelled 8.9 31 Fold:Bromodomain-like Superfamily:Mob1/phocein Family:Mob1/phocein 85 c1m04A_ not modelled 8.8 16 PDB header:hydrolase Chain: A: PDB Molecule:beta-n-acetylhexosaminidase; PDBTitle: mutant streptomyces plicatus beta-hexosaminidase (d313n) in complex2 with product (glcnac) 86 d2gjxa1 not modelled 8.6 16 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain 87 c2yuyA_ not modelled 8.5 14 PDB header:signaling protein Chain: A: PDB Molecule:rho gtpase activating protein 21; PDBTitle: solution structure of pdz domain of rho gtpase activating2 protein 21 88 c2yubA_ not modelled 8.4 15 PDB header:transferase Chain: A: PDB Molecule:lim domain kinase 2; PDBTitle: solution structure of the pdz domain from mouse lim domain2 kinase 89 d1u3ba2 not modelled 8.3 14 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 90 c2dm8A_ not modelled 8.1 19 PDB header:protein binding Chain: A: PDB Molecule:inad-like protein; PDBTitle: solution structure of the eighth pdz domain of human inad-2 like protein 91 d1qaua_ not modelled 8.0 24 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 92 c1obyA_ not modelled 7.9 14 PDB header:cell adhesion Chain: A: PDB Molecule:syntenin 1; PDBTitle: crystal structure of the complex of pdz2 of syntenin with2 a syndecan-4 peptide. 93 c1nouA_ not modelled 7.8 23 PDB header:hydrolase Chain: A: PDB Molecule:beta-hexosaminidase beta chain; PDBTitle: native human lysosomal beta-hexosaminidase isoform b 94 c2hjnA_ not modelled 7.7 23 PDB header:cell cycle Chain: A: PDB Molecule:maintenance of ploidy protein mob1; PDBTitle: structural and functional analysis of saccharomyces2 cerevisiae mob1 95 d1iyjb4 not modelled 7.6 18 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Single strand DNA-binding domain, SSB 96 d1wj2a_ not modelled 7.4 38 Fold:WRKY DNA-binding domain Superfamily:WRKY DNA-binding domain Family:WRKY DNA-binding domain 97 c3lfhF_ not modelled 7.3 62 PDB header:transferase Chain: F: PDB Molecule:phosphotransferase system, mannose/fructose-specific PDBTitle: crystal structure of manxa from thermoanaerobacter tengcongensis 98 c3enhD_ not modelled 7.3 22 PDB header:hydrolase/unknown function Chain: D: PDB Molecule:uncharacterized protein mj0187; PDBTitle: crystal structure of cgi121/bud32/kae1 complex 99 c4a8aI_ not modelled 7.3 27 PDB header:hydrolase/hydrolase Chain: I: PDB Molecule:periplasmic ph-dependent serine endoprotease degq; PDBTitle: asymmetric cryo-em reconstruction of e. coli degq 12-mer in complex2 with lysozyme