Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	N	D	I	K	W	V	Q	A	Q	R	K	A	T	D	W	R	Q	A	V	E	I	A	T	R	P	L	V	A	Y	G	A	A	Q	P	C	Y	V	N	G	I	I	E	N	T	L	N	W	G	P	Y	Y	L	I	A	P	G	I	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?		?																										?																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	P	H	A	R	P	E	Q	G	A	N	Y	N	Q	V	S	I	T	T	L	R	T	P	V	A	F	G	N	E	E	C	D	P	V	W	L	L	L	C	V	S	A	T	D	A	N	A	H	I	L	T	I	Q	R	I	S	Q	F	I	D
Secondary structure
SS confidence
Disorder																										?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.
Sequence		S	P	Q	R	L	T	A	V	G	N	A	S	T	D	D	A	L	F	A	L	V	S	G
Secondary structure
SS confidence
Disorder																							?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3oxp chain B Region: 2 - 142 Aligned: 141 Modelled: 141 Confidence: 100.0% Identity: 37% PDB header:transferase Chain: B: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution Phyre2 PDB 3oxp chain A Region: 2 - 142 Aligned: 141 Modelled: 141 Confidence: 100.0% Identity: 37% PDB header:transferase Chain: A: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution Phyre2 PDB 2oq3 chain A Region: 2 - 142 Aligned: 140 Modelled: 141 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: A: PDB Molecule:mannitol-specific cryptic phosphotransferase PDBTitle: solution structure of the mannitol- specific cryptic2 phosphotransferase enzyme iia cmtb from escherichia coli Phyre2 PDB 3bjv chain A Region: 2 - 142 Aligned: 139 Modelled: 139 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: A: PDB Molecule:rmpa; PDBTitle: the crystal structure of a putative pts iia(ptxa) from streptococcus2 mutans Phyre2 PDB 2oqt chain D Region: 2 - 142 Aligned: 139 Modelled: 139 Confidence: 100.0% Identity: 29% PDB header:transferase Chain: D: PDB Molecule:hypothetical protein spy0176; PDBTitle: structural genomics, the crystal structure of a putative2 pts iia domain from streptococcus pyogenes m1 gas Phyre2 PDB 1a3a chain A Region: 1 - 143 Aligned: 140 Modelled: 143 Confidence: 100.0% Identity: 25% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: IIA domain of mannitol-specific and ntr phosphotransferase EII Phyre2 PDB 1xiz chain A Region: 1 - 142 Aligned: 141 Modelled: 142 Confidence: 100.0% Identity: 17% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: IIA domain of mannitol-specific and ntr phosphotransferase EII Phyre2 PDB 3urr chain B Region: 2 - 141 Aligned: 136 Modelled: 140 Confidence: 99.9% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:pts iia-like nitrogen-regulatory protein ptsn; PDBTitle: structure of pts iia-like nitrogen-regulatory protein ptsn (bth_i0484)2 (ptsn) Phyre2 PDB 1a6j chain A Region: 2 - 142 Aligned: 139 Modelled: 141 Confidence: 99.9% Identity: 20% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: IIA domain of mannitol-specific and ntr phosphotransferase EII Phyre2 PDB 2a0j chain A Region: 2 - 142 Aligned: 138 Modelled: 141 Confidence: 99.9% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:pts system, nitrogen regulatory iia protein; PDBTitle: crystal structure of nitrogen regulatory protein iia-ntr from2 neisseria meningitidis Phyre2 PDB 1hyn chain Q Region: 8 - 141 Aligned: 134 Modelled: 134 Confidence: 96.9% Identity: 12% PDB header:membrane protein Chain: Q: PDB Molecule:band 3 anion transport protein; PDBTitle: crystal structure of the cytoplasmic domain of human2 erythrocyte band-3 protein Phyre2 PDB 1hyn chain P Region: 8 - 141 Aligned: 130 Modelled: 134 Confidence: 96.1% Identity: 13% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: Anion transport protein, cytoplasmic domain Phyre2 PDB 1gtd chain A Region: 6 - 36 Aligned: 31 Modelled: 31 Confidence: 22.2% Identity: 10% Fold: PurS-like Superfamily: PurS-like Family: PurS subunit of FGAM synthetase Phyre2 PDB 1sus chain A domain 1 Region: 6 - 61 Aligned: 56 Modelled: 56 Confidence: 19.9% Identity: 9% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: COMT-like Phyre2 PDB 1vq3 chain A Region: 6 - 36 Aligned: 31 Modelled: 31 Confidence: 15.9% Identity: 19% Fold: PurS-like Superfamily: PurS-like Family: PurS subunit of FGAM synthetase Phyre2 PDB 1a3x chain A domain 3 Region: 8 - 37 Aligned: 30 Modelled: 30 Confidence: 14.6% Identity: 7% Fold: Pyruvate kinase C-terminal domain-like Superfamily: PK C-terminal domain-like Family: Pyruvate kinase, C-terminal domain Phyre2 PDB 2avd chain A domain 1 Region: 6 - 61 Aligned: 56 Modelled: 56 Confidence: 13.3% Identity: 13% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: COMT-like Phyre2 PDB 1ept chain B Region: 60 - 88 Aligned: 29 Modelled: 29 Confidence: 12.5% Identity: 14% PDB header:hydrolase (serine protease) Chain: B: PDB Molecule:porcine e-trypsin; PDBTitle: refined 1.8 angstroms resolution crystal structure of2 porcine epsilon-trypsin Phyre2 PDB 3ntv chain B Region: 6 - 61 Aligned: 56 Modelled: 55 Confidence: 10.7% Identity: 20% PDB header:transferase Chain: B: PDB Molecule:mw1564 protein; PDBTitle: crystal structure of a putative caffeoyl-coa o-methyltransferase from2 staphylococcus aureus Phyre2 PDB 1vlf chain M domain 2 Region: 16 - 30 Aligned: 15 Modelled: 15 Confidence: 10.3% Identity: 20% Fold: Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily: Formate dehydrogenase/DMSO reductase, domains 1-3 Family: Formate dehydrogenase/DMSO reductase, domains 1-3 Phyre2 1 c3oxpB_ 2 c3oxpA_ 3 c2oq3A_ 4 c3bjvA_ 5 c2oqtD_ 6 d1a3aa_ 7 d1xiza_ 8 c3urrB_ 9 d1a6ja_ 10 c2a0jA_ 11 c1hynQ_ 12 d1hynp_ 13 d1gtda_ 14 d1susa1 15 d1vq3a_ 16 d1a3xa3 17 d2avda1 18 c1eptB_ 19 c3ntvB_ 20 d1vlfm2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3oxpB_ 100.0 37 PDB header:transferase Chain: B: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution 2 c3oxpA_ 100.0 37 PDB header:transferase Chain: A: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution 3 c2oq3A_ 100.0 34 PDB header:transferase Chain: A: PDB Molecule:mannitol-specific cryptic phosphotransferase PDBTitle: solution structure of the mannitol- specific cryptic2 phosphotransferase enzyme iia cmtb from escherichia coli 4 c3bjvA_ 100.0 35 PDB header:transferase Chain: A: PDB Molecule:rmpa; PDBTitle: the crystal structure of a putative pts iia(ptxa) from streptococcus2 mutans 5 c2oqtD_ 100.0 29 PDB header:transferase Chain: D: PDB Molecule:hypothetical protein spy0176; PDBTitle: structural genomics, the crystal structure of a putative2 pts iia domain from streptococcus pyogenes m1 gas 6 d1a3aa_ 100.0 25 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:IIA domain of mannitol-specific and ntr phosphotransferase EII 7 d1xiza_ 100.0 17 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:IIA domain of mannitol-specific and ntr phosphotransferase EII 8 c3urrB_ 99.9 19 PDB header:transferase Chain: B: PDB Molecule:pts iia-like nitrogen-regulatory protein ptsn; PDBTitle: structure of pts iia-like nitrogen-regulatory protein ptsn (bth_i0484)2 (ptsn) 9 d1a6ja_ 99.9 20 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:IIA domain of mannitol-specific and ntr phosphotransferase EII 10 c2a0jA_ 99.9 14 PDB header:transferase Chain: A: PDB Molecule:pts system, nitrogen regulatory iia protein; PDBTitle: crystal structure of nitrogen regulatory protein iia-ntr from2 neisseria meningitidis 11 c1hynQ_ 96.9 12 PDB header:membrane protein Chain: Q: PDB Molecule:band 3 anion transport protein; PDBTitle: crystal structure of the cytoplasmic domain of human2 erythrocyte band-3 protein 12 d1hynp_ 96.1 13 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:Anion transport protein, cytoplasmic domain 13 d1gtda_ 22.2 10 Fold:PurS-like Superfamily:PurS-like Family:PurS subunit of FGAM synthetase 14 d1susa1 19.9 9 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:COMT-like 15 d1vq3a_ 15.9 19 Fold:PurS-like Superfamily:PurS-like Family:PurS subunit of FGAM synthetase 16 d1a3xa3 14.6 7 Fold:Pyruvate kinase C-terminal domain-like Superfamily:PK C-terminal domain-like Family:Pyruvate kinase, C-terminal domain 17 d2avda1 13.3 13 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:COMT-like 18 c1eptB_ 12.5 14 PDB header:hydrolase (serine protease) Chain: B: PDB Molecule:porcine e-trypsin; PDBTitle: refined 1.8 angstroms resolution crystal structure of2 porcine epsilon-trypsin 19 c3ntvB_ 10.7 20 PDB header:transferase Chain: B: PDB Molecule:mw1564 protein; PDBTitle: crystal structure of a putative caffeoyl-coa o-methyltransferase from2 staphylococcus aureus 20 d1vlfm2 10.3 20 Fold:Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3 Family:Formate dehydrogenase/DMSO reductase, domains 1-3 21 c2hntE_ not modelled 9.6 25 PDB header:serine protease Chain: E: PDB Molecule:gamma-thrombin; PDBTitle: crystallographic structure of human gamma-thrombin 22 c1tmoA_ not modelled 9.4 20 PDB header:oxidoreductase Chain: A: PDB Molecule:trimethylamine n-oxide reductase; PDBTitle: trimethylamine n-oxide reductase from shewanella massilia 23 d2i5ua1 not modelled 9.2 21 Fold:DnaD domain-like Superfamily:DnaD domain-like Family:DnaD domain 24 d1g8ka2 not modelled 9.0 13 Fold:Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3 Family:Formate dehydrogenase/DMSO reductase, domains 1-3 25 c2dxbR_ not modelled 8.9 11 PDB header:hydrolase Chain: R: PDB Molecule:thiocyanate hydrolase subunit gamma; PDBTitle: recombinant thiocyanate hydrolase comprising partially-modified cobalt2 centers 26 c2fugC_ not modelled 8.7 18 PDB header:oxidoreductase Chain: C: PDB Molecule:nadh-quinone oxidoreductase chain 3; PDBTitle: crystal structure of the hydrophilic domain of respiratory complex i2 from thermus thermophilus 27 d2jioa2 not modelled 7.6 13 Fold:Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3 Family:Formate dehydrogenase/DMSO reductase, domains 1-3 28 d1dmra2 not modelled 7.5 20 Fold:Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3 Family:Formate dehydrogenase/DMSO reductase, domains 1-3 29 c1h5nC_ not modelled 7.5 20 PDB header:oxidoreductase Chain: C: PDB Molecule:dmso reductase; PDBTitle: dmso reductase modified by the presence of dms and air 30 c2zw2B_ not modelled 7.4 6 PDB header:ligase Chain: B: PDB Molecule:putative uncharacterized protein sts178; PDBTitle: crystal structure of formylglycinamide ribonucleotide amidotransferase2 iii from sulfolobus tokodaii (stpurs) 31 c1g8jC_ not modelled 7.1 13 PDB header:oxidoreductase Chain: C: PDB Molecule:arsenite oxidase; PDBTitle: crystal structure analysis of arsenite oxidase from2 alcaligenes faecalis 32 d1tmoa2 not modelled 7.0 20 Fold:Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3 Family:Formate dehydrogenase/DMSO reductase, domains 1-3 33 c1vlfQ_ not modelled 7.0 20 PDB header:oxidoreductase Chain: Q: PDB Molecule:pyrogallol hydroxytransferase large subunit; PDBTitle: crystal structure of pyrogallol-phloroglucinol2 transhydroxylase from pelobacter acidigallici complexed3 with inhibitor 1,2,4,5-tetrahydroxy-benzene 34 d1uhwa_ not modelled 7.0 14 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:DEP domain 35 d1e0ta3 not modelled 6.9 14 Fold:Pyruvate kinase C-terminal domain-like Superfamily:PK C-terminal domain-like Family:Pyruvate kinase, C-terminal domain 36 d1sxjb1 not modelled 6.7 13 Fold:post-AAA+ oligomerization domain-like Superfamily:post-AAA+ oligomerization domain-like Family:DNA polymerase III clamp loader subunits, C-terminal domain 37 d1eu1a2 not modelled 6.7 27 Fold:Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3 Family:Formate dehydrogenase/DMSO reductase, domains 1-3 38 c2yx5A_ not modelled 6.6 17 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0062 protein mj1593; PDBTitle: crystal structure of methanocaldococcus jannaschii purs, one of the2 subunits of formylglycinamide ribonucleotide amidotransferase in the3 purine biosynthetic pathway 39 c3c3pC_ not modelled 6.5 13 PDB header:transferase Chain: C: PDB Molecule:methyltransferase; PDBTitle: crystal structure of a methyltransferase (np_951602.1) from geobacter2 sulfurreducens at 1.90 a resolution 40 c3e3vA_ not modelled 6.5 7 PDB header:recombination Chain: A: PDB Molecule:regulatory protein recx; PDBTitle: crystal structure of recx from lactobacillus salivarius 41 d2csoa1 not modelled 6.3 11 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:DEP domain 42 d1kqfa2 not modelled 6.3 20 Fold:Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3 Family:Formate dehydrogenase/DMSO reductase, domains 1-3 43 d1v3fa_ not modelled 6.1 18 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:DEP domain 44 d2iv2x2 not modelled 6.1 27 Fold:Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3 Family:Formate dehydrogenase/DMSO reductase, domains 1-3 45 d1ogya2 not modelled 6.0 13 Fold:Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3 Family:Formate dehydrogenase/DMSO reductase, domains 1-3 46 c1h0hA_ not modelled 6.0 7 PDB header:dehydrogenase Chain: A: PDB Molecule:formate dehydrogenase (large subunit); PDBTitle: tungsten containing formate dehydrogenase from2 desulfovibrio gigas 47 c3cbgA_ not modelled 6.0 16 PDB header:transferase Chain: A: PDB Molecule:o-methyltransferase; PDBTitle: functional and structural characterization of a2 cationdependent o-methyltransferase from the3 cyanobacterium synechocystis sp. strain pcc 6803 48 c1eu1A_ not modelled 5.9 27 PDB header:oxidoreductase Chain: A: PDB Molecule:dimethyl sulfoxide reductase; PDBTitle: the crystal structure of rhodobacter sphaeroides dimethylsulfoxide2 reductase reveals two distinct molybdenum coordination environments. 49 d1y5ia2 not modelled 5.9 20 Fold:Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3 Family:Formate dehydrogenase/DMSO reductase, domains 1-3 50 c1ogyA_ not modelled 5.9 13 PDB header:oxidoreductase Chain: A: PDB Molecule:periplasmic nitrate reductase; PDBTitle: crystal structure of the heterodimeric nitrate reductase2 from rhodobacter sphaeroides 51 c1kqgA_ not modelled 5.9 20 PDB header:oxidoreductase Chain: A: PDB Molecule:formate dehydrogenase, nitrate-inducible, major subunit; PDBTitle: formate dehydrogenase n from e. coli 52 d2cs7a1 not modelled 5.7 19 Fold:IL8-like Superfamily:PhtA domain-like Family:PhtA domain-like 53 c3dfgA_ not modelled 5.6 17 PDB header:recombination Chain: A: PDB Molecule:regulatory protein recx; PDBTitle: crystal structure of recx: a potent inhibitor protein of2 reca from xanthomonas campestris 54 c2ivfA_ not modelled 5.6 13 PDB header:oxidoreductase Chain: A: PDB Molecule:ethylbenzene dehydrogenase alpha-subunit; PDBTitle: ethylbenzene dehydrogenase from aromatoleum aromaticum 55 d2g50a3 not modelled 5.6 25 Fold:Pyruvate kinase C-terminal domain-like Superfamily:PK C-terminal domain-like Family:Pyruvate kinase, C-terminal domain 56 c2e7zA_ not modelled 5.5 27 PDB header:lyase Chain: A: PDB Molecule:acetylene hydratase ahy; PDBTitle: acetylene hydratase from pelobacter acetylenicus 57 d1w4ma_ not modelled 5.5 11 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:DEP domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0