Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	T	F	S	Q	V	W	V	F	S	D	T	P	S	R	L	P	E	L	M	N	G	A	Q	A	L	A	N	Q	I	N	T	F	V	L	N	D	A	D	G	A	Q	A	I	Q	L	G	A	N	H	V	W	K	L	N	G	K	P	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	R	M	I	E	D	Y	A	G	V	M	A	D	T	I	R	Q	H	G	A	D	G	L	V	L	L	P	N	T	R	R	G	K	L	L	A	A	K	L	G	Y	R	L	K	A	A	V	S	N	D	A	S	T	V	S	V	Q	D	G	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	T	V	K	H	M	V	Y	G	G	L	A	I	G	E	E	R	I	A	T	P	Y	A	V	L	T	I	S	S	G	T	F	D	A	A	Q	P	D	A	S	R	T	G	E	T	H	T	V	E	W	Q	A	P	A	V	A	I	T	R	T
Secondary structure
SS confidence
Disorder																																		?	?	?	?	?	?	?	?	?	?	?										?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	T	Q	A	R	Q	S	N	S	V	D	L	D	K	A	R	L	V	V	S	V	G	R	G	I	G	S	K	E	N	I	A	L	A	E	Q	L	C	K	A	I	G	A	E	L	A	C	S	R	P	V	A	E	N	E	K	W	M	E	H
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?	?														?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	R	Y	V	G	I	S	N	L	M	L	K	P	E	L	Y	L	A	V	G	I	S	G	Q	I	Q	H	M	V	G	A	N	A	S	Q	T	I	F	A	I	N	K	D	K	N	A	P	I	F	Q	Y	A	D	Y	G	I	V	G	D	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.
Sequence		V	K	I	L	P	A	L	T	A	A	L	A	R
Secondary structure
SS confidence
Disorder													?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1efp chain C Region: 6 - 311 Aligned: 298 Modelled: 306 Confidence: 100.0% Identity: 31% PDB header:electron transport Chain: C: PDB Molecule:protein (electron transfer flavoprotein); PDBTitle: electron transfer flavoprotein (etf) from paracoccus2 denitrificans Phyre2 PDB 1efv chain A domain 2 Region: 188 - 312 Aligned: 124 Modelled: 125 Confidence: 100.0% Identity: 45% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: C-terminal domain of the electron transfer flavoprotein alpha subunit Phyre2 PDB 1efp chain A domain 2 Region: 187 - 311 Aligned: 124 Modelled: 125 Confidence: 100.0% Identity: 48% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: C-terminal domain of the electron transfer flavoprotein alpha subunit Phyre2 PDB 3cls chain D domain 2 Region: 189 - 311 Aligned: 122 Modelled: 123 Confidence: 100.0% Identity: 42% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: C-terminal domain of the electron transfer flavoprotein alpha subunit Phyre2 PDB 3ih5 chain A Region: 5 - 170 Aligned: 166 Modelled: 166 Confidence: 100.0% Identity: 16% PDB header:electron transport Chain: A: PDB Molecule:electron transfer flavoprotein alpha-subunit; PDBTitle: crystal structure of electron transfer flavoprotein alpha-2 subunit from bacteroides thetaiotaomicron Phyre2 PDB 1efv chain A domain 1 Region: 5 - 187 Aligned: 179 Modelled: 183 Confidence: 100.0% Identity: 13% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 3cls chain D domain 1 Region: 5 - 178 Aligned: 173 Modelled: 173 Confidence: 100.0% Identity: 16% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 1t9g chain R Region: 5 - 183 Aligned: 175 Modelled: 178 Confidence: 100.0% Identity: 14% PDB header:oxidoreductase, electron transport Chain: R: PDB Molecule:electron transfer flavoprotein alpha-subunit, PDBTitle: structure of the human mcad:etf complex Phyre2 PDB 1o94 chain D Region: 5 - 178 Aligned: 173 Modelled: 174 Confidence: 100.0% Identity: 17% PDB header:electron transport Chain: D: PDB Molecule:electron transfer flavoprotein alpha-subunit; PDBTitle: ternary complex between trimethylamine dehydrogenase and2 electron transferring flavoprotein Phyre2 PDB 1efp chain A domain 1 Region: 6 - 177 Aligned: 167 Modelled: 172 Confidence: 100.0% Identity: 17% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 3fet chain A Region: 2 - 177 Aligned: 162 Modelled: 172 Confidence: 100.0% Identity: 18% PDB header:electron transport Chain: A: PDB Molecule:electron transfer flavoprotein subunit alpha related PDBTitle: crystal structure of the electron transfer flavoprotein subunit alpha2 related protein ta0212 from thermoplasma acidophilum Phyre2 PDB 1efv chain B Region: 8 - 221 Aligned: 201 Modelled: 214 Confidence: 99.8% Identity: 16% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 3cls chain C domain 1 Region: 8 - 221 Aligned: 206 Modelled: 214 Confidence: 99.8% Identity: 13% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 1efp chain B Region: 8 - 196 Aligned: 183 Modelled: 186 Confidence: 99.8% Identity: 15% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 1o94 chain C Region: 8 - 157 Aligned: 148 Modelled: 150 Confidence: 99.7% Identity: 15% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 1t9b chain A domain 1 Region: 192 - 313 Aligned: 119 Modelled: 122 Confidence: 98.9% Identity: 14% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 1ozh chain A domain 1 Region: 192 - 313 Aligned: 122 Modelled: 122 Confidence: 98.8% Identity: 16% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 2ez9 chain A domain 1 Region: 192 - 313 Aligned: 119 Modelled: 122 Confidence: 98.5% Identity: 23% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 2ji7 chain A domain 1 Region: 196 - 313 Aligned: 115 Modelled: 118 Confidence: 98.4% Identity: 16% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 2iht chain A domain 1 Region: 192 - 313 Aligned: 119 Modelled: 122 Confidence: 98.3% Identity: 17% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 1 c1efpC_ 2 d1efva2 3 d1efpa2 4 d3clsd2 5 c3ih5A_ 6 d1efva1 7 d3clsd1 8 c1t9gR_ 9 c1o94D_ 10 d1efpa1 11 c3fetA_ 12 d1efvb_ 13 d3clsc1 14 d1efpb_ 15 d1o94c_ 16 d1t9ba1 17 d1ozha1 18 d2ez9a1 19 d2ji7a1 20 d2ihta1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1efpC_ 100.0 31 PDB header:electron transport Chain: C: PDB Molecule:protein (electron transfer flavoprotein); PDBTitle: electron transfer flavoprotein (etf) from paracoccus2 denitrificans 2 d1efva2 100.0 45 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:C-terminal domain of the electron transfer flavoprotein alpha subunit 3 d1efpa2 100.0 48 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:C-terminal domain of the electron transfer flavoprotein alpha subunit 4 d3clsd2 100.0 42 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:C-terminal domain of the electron transfer flavoprotein alpha subunit 5 c3ih5A_ 100.0 16 PDB header:electron transport Chain: A: PDB Molecule:electron transfer flavoprotein alpha-subunit; PDBTitle: crystal structure of electron transfer flavoprotein alpha-2 subunit from bacteroides thetaiotaomicron 6 d1efva1 100.0 13 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 7 d3clsd1 100.0 16 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 8 c1t9gR_ 100.0 14 PDB header:oxidoreductase, electron transport Chain: R: PDB Molecule:electron transfer flavoprotein alpha-subunit, PDBTitle: structure of the human mcad:etf complex 9 c1o94D_ 100.0 17 PDB header:electron transport Chain: D: PDB Molecule:electron transfer flavoprotein alpha-subunit; PDBTitle: ternary complex between trimethylamine dehydrogenase and2 electron transferring flavoprotein 10 d1efpa1 100.0 17 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 11 c3fetA_ 100.0 18 PDB header:electron transport Chain: A: PDB Molecule:electron transfer flavoprotein subunit alpha related PDBTitle: crystal structure of the electron transfer flavoprotein subunit alpha2 related protein ta0212 from thermoplasma acidophilum 12 d1efvb_ 99.8 16 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 13 d3clsc1 99.8 13 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 14 d1efpb_ 99.8 15 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 15 d1o94c_ 99.7 15 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 16 d1t9ba1 98.9 14 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 17 d1ozha1 98.8 16 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 18 d2ez9a1 98.5 23 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 19 d2ji7a1 98.4 16 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 20 d2ihta1 98.3 17 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 21 d1q6za1 not modelled 98.0 15 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 22 c1ozhD_ not modelled 98.0 16 PDB header:lyase Chain: D: PDB Molecule:acetolactate synthase, catabolic; PDBTitle: the crystal structure of klebsiella pneumoniae acetolactate2 synthase with enzyme-bound cofactor and with an unusual3 intermediate. 23 d1ybha1 not modelled 97.8 17 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 24 c2q27B_ not modelled 97.7 13 PDB header:lyase Chain: B: PDB Molecule:oxalyl-coa decarboxylase; PDBTitle: crystal structure of oxalyl-coa decarboxylase from escherichia coli 25 d2djia1 not modelled 97.6 19 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 26 c1powA_ not modelled 97.6 22 PDB header:oxidoreductase(oxygen as acceptor) Chain: A: PDB Molecule:pyruvate oxidase; PDBTitle: the refined structures of a stabilized mutant and of wild-type2 pyruvate oxidase from lactobacillus plantarum 27 c2pgnA_ not modelled 97.5 14 PDB header:hydrolase Chain: A: PDB Molecule:cyclohexane-1,2-dione hydrolase (cdh); PDBTitle: the crystal structure of fad and thdp-dependent cyclohexane-1,2-dione2 hydrolase in complex with cyclohexane-1,2-dione 28 c2djiA_ not modelled 97.5 19 PDB header:oxidoreductase Chain: A: PDB Molecule:pyruvate oxidase; PDBTitle: crystal structure of pyruvate oxidase from aerococcus2 viridans containing fad 29 c3lq1A_ not modelled 97.4 15 PDB header:transferase Chain: A: PDB Molecule:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene- PDBTitle: crystal structure of 2-succinyl-6-hydroxy-2,4-cyclohexadiene2 1-carboxylic acid synthase/2-oxoglutarate decarboxylase3 from listeria monocytogenes str. 4b f2365 30 c2ji6B_ not modelled 97.4 17 PDB header:lyase Chain: B: PDB Molecule:oxalyl-coa decarboxylase; PDBTitle: x-ray structure of oxalyl-coa decarboxylase in complex with2 3-deaza-thdp and oxalyl-coa 31 c1t9dB_ not modelled 97.3 17 PDB header:transferase Chain: B: PDB Molecule:acetolactate synthase, mitochondrial; PDBTitle: crystal structure of yeast acetohydroxyacid synthase in2 complex with a sulfonylurea herbicide, metsulfuron methyl 32 c1upaC_ not modelled 97.1 14 PDB header:synthase Chain: C: PDB Molecule:carboxyethylarginine synthase; PDBTitle: carboxyethylarginine synthase from streptomyces2 clavuligerus (semet structure) 33 c1yi1A_ not modelled 97.0 16 PDB header:transferase Chain: A: PDB Molecule:acetolactate synthase; PDBTitle: crystal structure of arabidopsis thaliana acetohydroxyacid synthase in2 complex with a sulfonylurea herbicide, tribenuron methyl 34 c2ag1A_ not modelled 97.0 20 PDB header:lyase Chain: A: PDB Molecule:benzaldehyde lyase; PDBTitle: crystal structure of benzaldehyde lyase (bal)- semet 35 c3eyaE_ not modelled 96.9 16 PDB header:oxidoreductase Chain: E: PDB Molecule:pyruvate dehydrogenase [cytochrome]; PDBTitle: structural basis for membrane binding and catalytic2 activation of the peripheral membrane enzyme pyruvate3 oxidase from escherichia coli 36 c2panF_ not modelled 96.7 20 PDB header:lyase Chain: F: PDB Molecule:glyoxylate carboligase; PDBTitle: crystal structure of e. coli glyoxylate carboligase 37 c2v3wC_ not modelled 96.6 15 PDB header:lyase Chain: C: PDB Molecule:benzoylformate decarboxylase; PDBTitle: crystal structure of the benzoylformate decarboxylase2 variant l461a from pseudomonas putida 38 c2x7jA_ not modelled 96.6 16 PDB header:transferase Chain: A: PDB Molecule:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene PDBTitle: structure of the menaquinone biosynthesis protein mend from2 bacillus subtilis 39 d1zpda1 not modelled 96.5 15 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 40 d1pvda1 not modelled 96.2 15 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 41 d1m2ka_ not modelled 96.1 23 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 42 d1yc5a1 not modelled 96.0 14 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 43 c1jscA_ not modelled 95.9 14 PDB header:lyase Chain: A: PDB Molecule:acetohydroxy-acid synthase; PDBTitle: crystal structure of the catalytic subunit of yeast2 acetohydroxyacid synthase: a target for herbicidal3 inhibitors 44 d2b4ya1 not modelled 95.4 21 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 45 c3glsC_ not modelled 95.2 27 PDB header:hydrolase Chain: C: PDB Molecule:nad-dependent deacetylase sirtuin-3, PDBTitle: crystal structure of human sirt3 46 c3k35D_ not modelled 95.1 22 PDB header:hydrolase Chain: D: PDB Molecule:nad-dependent deacetylase sirtuin-6; PDBTitle: crystal structure of human sirt6 47 c1zpdA_ not modelled 94.9 14 PDB header:alcohol fermentation Chain: A: PDB Molecule:pyruvate decarboxylase; PDBTitle: pyruvate decarboxylase from zymomonas mobilis 48 d1ma3a_ not modelled 94.9 21 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 49 c3pkiF_ not modelled 94.5 20 PDB header:hydrolase Chain: F: PDB Molecule:nad-dependent deacetylase sirtuin-6; PDBTitle: human sirt6 crystal structure in complex with adp ribose 50 c2vbiF_ not modelled 94.4 11 PDB header:lyase Chain: F: PDB Molecule:pyruvate decarboxylase; PDBTitle: holostructure of pyruvate decarboxylase from acetobacter2 pasteurianus 51 c2jlaD_ not modelled 94.3 11 PDB header:transferase Chain: D: PDB Molecule:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene PDBTitle: crystal structure of e.coli mend, 2-succinyl-5-enolpyruvyl-2 6-hydroxy-3-cyclohexadiene-1-carboxylate synthase - semet3 protein 52 d1q1aa_ not modelled 94.3 13 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 53 c1q14A_ not modelled 93.5 13 PDB header:hydrolase Chain: A: PDB Molecule:hst2 protein; PDBTitle: structure and autoregulation of the yeast hst2 homolog of sir2 54 d1ovma1 not modelled 93.2 12 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 55 c2w93A_ not modelled 92.7 17 PDB header:lyase Chain: A: PDB Molecule:pyruvate decarboxylase isozyme 1; PDBTitle: crystal structure of the saccharomyces cerevisiae pyruvate2 decarboxylase variant e477q in complex with the surrogate3 pyruvamide 56 d1s5pa_ not modelled 92.5 21 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 57 d1j8fa_ not modelled 91.7 32 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 58 c3jwpA_ not modelled 90.7 22 PDB header:transcription Chain: A: PDB Molecule:transcriptional regulatory protein sir2 homologue; PDBTitle: crystal structure of plasmodium falciparum sir2a (pf13_0152) in2 complex with amp 59 c2hjhB_ not modelled 90.0 16 PDB header:hydrolase Chain: B: PDB Molecule:nad-dependent histone deacetylase sir2; PDBTitle: crystal structure of the sir2 deacetylase 60 c1ovmC_ not modelled 89.6 13 PDB header:lyase Chain: C: PDB Molecule:indole-3-pyruvate decarboxylase; PDBTitle: crystal structure of indolepyruvate decarboxylase from2 enterobacter cloacae 61 c2vbgB_ not modelled 88.9 13 PDB header:lyase Chain: B: PDB Molecule:branched-chain alpha-ketoacid decarboxylase; PDBTitle: the complex structure of the branched-chain keto acid2 decarboxylase (kdca) from lactococcus lactis with 2r-1-3 hydroxyethyl-deazathdp 62 c2nxwB_ not modelled 87.5 13 PDB header:lyase Chain: B: PDB Molecule:phenyl-3-pyruvate decarboxylase; PDBTitle: crystal structure of phenylpyruvate decarboxylase of azospirillum2 brasilense 63 c3cf4G_ not modelled 84.7 21 PDB header:oxidoreductase Chain: G: PDB Molecule:acetyl-coa decarboxylase/synthase epsilon subunit; PDBTitle: structure of the codh component of the m. barkeri acds complex 64 d1uana_ not modelled 83.4 13 Fold:LmbE-like Superfamily:LmbE-like Family:LmbE-like 65 d1tq8a_ not modelled 82.7 16 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:Universal stress protein-like 66 d1x94a_ not modelled 78.7 16 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 67 c2x3yA_ not modelled 77.3 15 PDB header:isomerase Chain: A: PDB Molecule:phosphoheptose isomerase; PDBTitle: crystal structure of gmha from burkholderia pseudomallei 68 c2ixdB_ not modelled 70.3 11 PDB header:hydrolase Chain: B: PDB Molecule:lmbe-related protein; PDBTitle: crystal structure of the putative deacetylase bc1534 from2 bacilus cereus 69 c2pn1A_ not modelled 67.2 16 PDB header:ligase Chain: A: PDB Molecule:carbamoylphosphate synthase large subunit; PDBTitle: crystal structure of carbamoylphosphate synthase large subunit (split2 gene in mj) (zp_00538348.1) from exiguobacterium sp. 255-15 at 2.00 a3 resolution 70 c3fxaA_ not modelled 59.9 14 PDB header:sugar binding protein Chain: A: PDB Molecule:sis domain protein; PDBTitle: crystal structure of a putative sugar-phosphate isomerase2 (lmof2365_0531) from listeria monocytogenes str. 4b f2365 at 1.60 a3 resolution 71 c2ze5A_ not modelled 53.9 19 PDB header:transferase Chain: A: PDB Molecule:isopentenyl transferase; PDBTitle: crystal structure of adenosine phosphate-isopentenyltransferase 72 c1nvmG_ not modelled 52.7 12 PDB header:lyase/oxidoreductase Chain: G: PDB Molecule:4-hydroxy-2-oxovalerate aldolase; PDBTitle: crystal structure of a bifunctional aldolase-dehydrogenase :2 sequestering a reactive and volatile intermediate 73 c3shoA_ not modelled 52.0 21 PDB header:transcription regulator Chain: A: PDB Molecule:transcriptional regulator, rpir family; PDBTitle: crystal structure of rpir transcription factor from sphaerobacter2 thermophilus (sugar isomerase domain) 74 d1tk9a_ not modelled 51.7 14 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 75 c2xhzC_ not modelled 49.5 13 PDB header:isomerase Chain: C: PDB Molecule:arabinose 5-phosphate isomerase; PDBTitle: probing the active site of the sugar isomerase domain from e. coli2 arabinose-5-phosphate isomerase via x-ray crystallography 76 c1nriA_ not modelled 46.1 13 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein hi0754; PDBTitle: crystal structure of putative phosphosugar isomerase hi0754 from2 haemophilus influenzae 77 d1nria_ not modelled 46.1 13 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 78 c3d3qB_ not modelled 45.1 16 PDB header:transferase Chain: B: PDB Molecule:trna delta(2)-isopentenylpyrophosphate PDBTitle: crystal structure of trna delta(2)-isopentenylpyrophosphate2 transferase (se0981) from staphylococcus epidermidis.3 northeast structural genomics consortium target ser100 79 c3dahB_ not modelled 44.4 10 PDB header:transferase Chain: B: PDB Molecule:ribose-phosphate pyrophosphokinase; PDBTitle: 2.3 a crystal structure of ribose-phosphate pyrophosphokinase from2 burkholderia pseudomallei 80 d1moqa_ not modelled 44.1 13 Fold:SIS domain Superfamily:SIS domain Family:double-SIS domain 81 c2dwcB_ not modelled 44.0 20 PDB header:transferase Chain: B: PDB Molecule:433aa long hypothetical phosphoribosylglycinamide formyl PDBTitle: crystal structure of probable phosphoribosylglycinamide formyl2 transferase from pyrococcus horikoshii ot3 complexed with adp 82 c3uvzB_ not modelled 42.5 16 PDB header:lyase Chain: B: PDB Molecule:phosphoribosylaminoimidazole carboxylase, atpase subunit; PDBTitle: crystal structure of phosphoribosylaminoimidazole carboxylase, atpase2 subunit from burkholderia ambifaria 83 d2iyva1 not modelled 42.0 21 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Shikimate kinase (AroK) 84 c2amlB_ not modelled 41.3 20 PDB header:transferase Chain: B: PDB Molecule:sis domain protein; PDBTitle: crystal structure of lmo0035 protein (46906266) from listeria2 monocytogenes 4b f2365 at 1.50 a resolution 85 d1kjqa2 not modelled 40.9 17 Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:BC N-terminal domain-like 86 c3crqA_ not modelled 40.1 27 PDB header:transferase Chain: A: PDB Molecule:trna delta(2)-isopentenylpyrophosphate PDBTitle: structure of trna dimethylallyltransferase: rna2 modification through a channel 87 c3exaD_ not modelled 40.0 23 PDB header:transferase Chain: D: PDB Molecule:trna delta(2)-isopentenylpyrophosphate PDBTitle: crystal structure of the full-length trna2 isopentenylpyrophosphate transferase (bh2366) from3 bacillus halodurans, northeast structural genomics4 consortium target bhr41. 88 c1u9yD_ not modelled 38.1 13 PDB header:transferase Chain: D: PDB Molecule:ribose-phosphate pyrophosphokinase; PDBTitle: crystal structure of phosphoribosyl diphosphate synthase2 from methanocaldococcus jannaschii 89 c3ga2A_ not modelled 36.3 14 PDB header:hydrolase Chain: A: PDB Molecule:endonuclease v; PDBTitle: crystal structure of the endonuclease_v (bsu36170) from2 bacillus subtilis, northeast structural genomics3 consortium target sr624 90 c3a8tA_ not modelled 35.1 31 PDB header:transferase Chain: A: PDB Molecule:adenylate isopentenyltransferase; PDBTitle: plant adenylate isopentenyltransferase in complex with atp 91 c1dkrB_ not modelled 33.6 19 PDB header:transferase Chain: B: PDB Molecule:phosphoribosyl pyrophosphate synthetase; PDBTitle: crystal structures of bacillus subtilis phosphoribosylpyrophosphate2 synthetase: molecular basis of allosteric inhibition and activation. 92 c3euaD_ not modelled 32.9 29 PDB header:isomerase Chain: D: PDB Molecule:putative fructose-aminoacid-6-phosphate deglycase; PDBTitle: crystal structure of a putative phosphosugar isomerase (bsu32610) from2 bacillus subtilis at 1.90 a resolution 93 d1jmva_ not modelled 32.8 13 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:Universal stress protein-like 94 c3bo9B_ not modelled 30.8 12 PDB header:oxidoreductase Chain: B: PDB Molecule:putative nitroalkan dioxygenase; PDBTitle: crystal structure of putative nitroalkan dioxygenase (tm0800) from2 thermotoga maritima at 2.71 a resolution 95 c3t61A_ not modelled 30.8 9 PDB header:transferase Chain: A: PDB Molecule:gluconokinase; PDBTitle: crystal structure of a gluconokinase from sinorhizobium meliloti 1021 96 d1q77a_ not modelled 30.5 14 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:Universal stress protein-like 97 d1kaga_ not modelled 30.4 16 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Shikimate kinase (AroK) 98 c3trjC_ not modelled 29.7 12 PDB header:isomerase Chain: C: PDB Molecule:phosphoheptose isomerase; PDBTitle: structure of a phosphoheptose isomerase from francisella tularensis 99 c3fozB_ not modelled 28.9 27 PDB header:transferase/rna Chain: B: PDB Molecule:trna delta(2)-isopentenylpyrophosphate transferase; PDBTitle: structure of e. coli isopentenyl-trna transferase in complex with e.2 coli trna(phe) 100 c3m0zD_ not modelled 28.7 22 PDB header:lyase Chain: D: PDB Molecule:putative aldolase; PDBTitle: crystal structure of putative aldolase from klebsiella2 pneumoniae. 101 d1a9xa4 not modelled 28.5 9 Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:BC N-terminal domain-like 102 d1nvma2 not modelled 27.4 11 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:HMGL-like 103 c3tbfA_ not modelled 27.3 13 PDB header:transferase Chain: A: PDB Molecule:glucosamine--fructose-6-phosphate aminotransferase PDBTitle: c-terminal domain of glucosamine-fructose-6-phosphate aminotransferase2 from francisella tularensis. 104 c2p3wB_ not modelled 25.8 21 PDB header:protein binding Chain: B: PDB Molecule:probable serine protease htra3; PDBTitle: crystal structure of the htra3 pdz domain bound to a phage-derived2 ligand (fgrwv) 105 d1pama3 not modelled 25.5 31 Fold:Glycosyl hydrolase domain Superfamily:Glycosyl hydrolase domain Family:alpha-Amylases, C-terminal beta-sheet domain 106 d1nt2a_ not modelled 25.4 19 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Fibrillarin homologue 107 c3eplA_ not modelled 24.8 26 PDB header:transferase/rna Chain: A: PDB Molecule:trna isopentenyltransferase; PDBTitle: crystallographic snapshots of eukaryotic2 dimethylallyltransferase acting on trna: insight into trna3 recognition and reaction mechanism 108 c1rr2A_ not modelled 24.8 10 PDB header:transferase Chain: A: PDB Molecule:transcarboxylase 5s subunit; PDBTitle: propionibacterium shermanii transcarboxylase 5s subunit bound to 2-2 ketobutyric acid 109 d1rkba_ not modelled 24.1 21 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nucleotide and nucleoside kinases 110 c3be4A_ not modelled 23.5 16 PDB header:transferase Chain: A: PDB Molecule:adenylate kinase; PDBTitle: crystal structure of cryptosporidium parvum adenylate kinase cgd5_3360 111 c3lpnB_ not modelled 23.5 8 PDB header:transferase Chain: B: PDB Molecule:ribose-phosphate pyrophosphokinase; PDBTitle: crystal structure of the phosphoribosylpyrophosphate (prpp) synthetase2 from thermoplasma volcanium in complex with an atp analog (ampcpp). 112 d1cxla3 not modelled 22.1 38 Fold:Glycosyl hydrolase domain Superfamily:Glycosyl hydrolase domain Family:alpha-Amylases, C-terminal beta-sheet domain 113 c3muxB_ not modelled 21.8 23 PDB header:lyase Chain: B: PDB Molecule:putative 4-hydroxy-2-oxoglutarate aldolase; PDBTitle: the crystal structure of a putative 4-hydroxy-2-oxoglutarate aldolase2 from bacillus anthracis to 1.45a 114 c3m6yA_ not modelled 21.4 23 PDB header:lyase Chain: A: PDB Molecule:4-hydroxy-2-oxoglutarate aldolase; PDBTitle: structure of 4-hydroxy-2-oxoglutarate aldolase from bacillus cereus at2 1.45 a resolution. 115 c2k1hA_ not modelled 21.4 24 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ser13; PDBTitle: solution nmr structure of ser13 from staphylococcus epidermidis.2 northeast structural genomics consortium target ser13 116 d1g8sa_ not modelled 20.7 19 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Fibrillarin homologue

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0