Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	W	Q	G	R	R	E	S	D	N	V	E	D	R	R	N	S	S	G	G	P	S	M	G	G	P	G	F	R	L	P	S	G	K	G	G	L	I	L	L	I	V	V	L	V	A	G	Y	Y	G	V	D	L	T	G	L	M	T	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	P	V	S	Q	Q	Q	S	T	R	S	I	S	P	N	E	D	E	A	A	K	F	T	S	V	I	L	A	T	T	E	D	T	W	G	Q	Q	F	E	K	M	G	K	T	Y	Q	Q	P	K	L	V	M	Y	R	G	M	T	R	T	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																										?														?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		C	G	A	G	Q	S	I	M	G	P	F	Y	C	P	A	D	G	T	V	Y	I	D	L	S	F	Y	D	D	M	K	D	K	L	G	A	D	G	D	F	A	Q	G	Y	V	I	A	H	E	V	G	H	H	V	Q	K	L	L	G	I	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	K	V	R	Q	L	Q	Q	N	A	T	Q	A	E	V	N	R	L	S	V	R	M	E	L	Q	A	D	C	F	A	G	V	W	G	H	S	M	Q	Q	Q	G	V	L	E	T	G	D	L	E	E	A	L	N	A	A	Q	A	I	G	D
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?	?	?	?																						?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.
Sequence		D	R	L	Q	Q	Q	S	Q	G	R	V	V	P	D	S	F	T	H	G	T	S	Q	Q	R	Y	S	W	F	K	R	G	F	D	S	G	D	P	A	Q	C	N	T	F	G	K	S	I
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?	?	?	?	?	?																			?					?		?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3c37 chain B Region: 90 - 270 Aligned: 141 Modelled: 162 Confidence: 98.2% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:peptidase, m48 family; PDBTitle: x-ray structure of the putative zn-dependent peptidase q74d82 at the2 resolution 1.7 a. northeast structural genomics consortium target3 gsr143a Phyre2 PDB 3dtk chain A Region: 131 - 214 Aligned: 68 Modelled: 84 Confidence: 96.7% Identity: 16% PDB header:gene regulation Chain: A: PDB Molecule:irre protein; PDBTitle: crystal structure of the irre protein, a central regulator2 of dna damage repair in deinococcaceae Phyre2 PDB 3cqb chain B Region: 90 - 171 Aligned: 66 Modelled: 82 Confidence: 95.6% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:probable protease htpx homolog; PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633 Phyre2 PDB 3sks chain A Region: 156 - 204 Aligned: 48 Modelled: 49 Confidence: 91.6% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:putative oligoendopeptidase f; PDBTitle: crystal structure of a putative oligoendopeptidase f from bacillus2 anthracis str. ames Phyre2 PDB 2vqx chain A Region: 164 - 220 Aligned: 45 Modelled: 57 Confidence: 90.5% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:metalloproteinase; PDBTitle: precursor of protealysin, metalloproteinase from serratia2 proteamaculans. Phyre2 PDB 1kjp chain A Region: 164 - 220 Aligned: 45 Modelled: 57 Confidence: 90.2% Identity: 24% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Thermolysin-like Phyre2 PDB 1npc chain A Region: 164 - 220 Aligned: 45 Modelled: 57 Confidence: 90.2% Identity: 27% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Thermolysin-like Phyre2 PDB 1bqb chain A Region: 164 - 210 Aligned: 35 Modelled: 47 Confidence: 89.7% Identity: 31% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Thermolysin-like Phyre2 PDB 1i1i chain P Region: 159 - 234 Aligned: 75 Modelled: 76 Confidence: 89.6% Identity: 16% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Neurolysin-like Phyre2 PDB 1y79 chain 1 Region: 159 - 204 Aligned: 46 Modelled: 46 Confidence: 89.6% Identity: 20% PDB header:hydrolase Chain: 1: PDB Molecule:peptidyl-dipeptidase dcp; PDBTitle: crystal structure of the e.coli dipeptidyl carboxypeptidase2 dcp in complex with a peptidic inhibitor Phyre2 PDB 3ce2 chain A Region: 156 - 204 Aligned: 48 Modelled: 49 Confidence: 89.5% Identity: 21% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative peptidase; PDBTitle: crystal structure of putative peptidase from chlamydophila abortus Phyre2 PDB 3nqz chain B Region: 164 - 220 Aligned: 45 Modelled: 57 Confidence: 88.7% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of the autoprocessed vibriolysin mcp-02 with e369a2 mutation Phyre2 PDB 3nqx chain A Region: 164 - 220 Aligned: 45 Modelled: 57 Confidence: 88.1% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of vibriolysin mcp-02 mature enzyme, a zinc2 metalloprotease from m4 family Phyre2 PDB 2h1j chain A Region: 156 - 177 Aligned: 22 Modelled: 22 Confidence: 87.9% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:oligoendopeptidase f; PDBTitle: 3.1 a x-ray structure of putative oligoendopeptidase f: crystals grown2 by microfluidic seeding Phyre2 PDB 1s4b chain P Region: 157 - 204 Aligned: 48 Modelled: 48 Confidence: 86.9% Identity: 17% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Neurolysin-like Phyre2 PDB 3dwb chain A Region: 80 - 238 Aligned: 142 Modelled: 156 Confidence: 85.1% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:endothelin-converting enzyme 1; PDBTitle: structure of human ece-1 complexed with phosphoramidon Phyre2 PDB 2ejq chain A domain 1 Region: 164 - 178 Aligned: 15 Modelled: 15 Confidence: 84.7% Identity: 40% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: TTHA0227-like Phyre2 PDB 1dmt chain A Region: 80 - 213 Aligned: 117 Modelled: 127 Confidence: 84.2% Identity: 16% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Neutral endopeptidase (neprilysin) Phyre2 PDB 1r55 chain A Region: 158 - 171 Aligned: 14 Modelled: 14 Confidence: 83.8% Identity: 36% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 3k7l chain A Region: 158 - 171 Aligned: 14 Modelled: 14 Confidence: 83.7% Identity: 36% PDB header:hydrolase Chain: A: PDB Molecule:atragin; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins Phyre2 PDB 3mdj chain B Region: 73 - 172 Aligned: 87 Modelled: 87 Confidence: 71.3% Identity: 20% PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: er aminopeptidase, erap1, bound to the zinc aminopeptidase inhibitor,2 bestatin Phyre2 1 c3c37B_ 2 c3dtkA_ 3 c3cqbB_ 4 c3sksA_ 5 c2vqxA_ 6 d1kjpa_ 7 d1npca_ 8 d1bqba_ 9 d1i1ip_ 10 c1y791_ 11 c3ce2A_ 12 c3nqzB_ 13 c3nqxA_ 14 c2h1jA_ 15 d1s4bp_ 16 c3dwbA_ 17 d2ejqa1 18 d1dmta_ 19 d1r55a_ 20 c3k7lA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 c3mdjB_ 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3c37B_ 98.2 18 PDB header:hydrolase Chain: B: PDB Molecule:peptidase, m48 family; PDBTitle: x-ray structure of the putative zn-dependent peptidase q74d82 at the2 resolution 1.7 a. northeast structural genomics consortium target3 gsr143a 2 c3dtkA_ 96.7 16 PDB header:gene regulation Chain: A: PDB Molecule:irre protein; PDBTitle: crystal structure of the irre protein, a central regulator2 of dna damage repair in deinococcaceae 3 c3cqbB_ 95.6 24 PDB header:hydrolase Chain: B: PDB Molecule:probable protease htpx homolog; PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633 4 c3sksA_ 91.6 23 PDB header:hydrolase Chain: A: PDB Molecule:putative oligoendopeptidase f; PDBTitle: crystal structure of a putative oligoendopeptidase f from bacillus2 anthracis str. ames 5 c2vqxA_ 90.5 20 PDB header:hydrolase Chain: A: PDB Molecule:metalloproteinase; PDBTitle: precursor of protealysin, metalloproteinase from serratia2 proteamaculans. 6 d1kjpa_ 90.2 24 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 7 d1npca_ 90.2 27 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 8 d1bqba_ 89.7 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 9 d1i1ip_ 89.6 16 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 10 c1y791_ 89.6 20 PDB header:hydrolase Chain: 1: PDB Molecule:peptidyl-dipeptidase dcp; PDBTitle: crystal structure of the e.coli dipeptidyl carboxypeptidase2 dcp in complex with a peptidic inhibitor 11 c3ce2A_ 89.5 21 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative peptidase; PDBTitle: crystal structure of putative peptidase from chlamydophila abortus 12 c3nqzB_ 88.7 22 PDB header:hydrolase Chain: B: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of the autoprocessed vibriolysin mcp-02 with e369a2 mutation 13 c3nqxA_ 88.1 24 PDB header:hydrolase Chain: A: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of vibriolysin mcp-02 mature enzyme, a zinc2 metalloprotease from m4 family 14 c2h1jA_ 87.9 32 PDB header:hydrolase Chain: A: PDB Molecule:oligoendopeptidase f; PDBTitle: 3.1 a x-ray structure of putative oligoendopeptidase f: crystals grown2 by microfluidic seeding 15 d1s4bp_ 86.9 17 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 16 c3dwbA_ 85.1 11 PDB header:hydrolase Chain: A: PDB Molecule:endothelin-converting enzyme 1; PDBTitle: structure of human ece-1 complexed with phosphoramidon 17 d2ejqa1 84.7 40 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:TTHA0227-like 18 d1dmta_ 84.2 16 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neutral endopeptidase (neprilysin) 19 d1r55a_ 83.8 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 20 c3k7lA_ 83.7 36 PDB header:hydrolase Chain: A: PDB Molecule:atragin; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins 21 d1u4ga_ not modelled 83.7 43 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Thermolysin-like 22 c2dw1B_ not modelled 82.6 36 PDB header:apoptosis, toxin Chain: B: PDB Molecule:catrocollastatin; PDBTitle: crystal structure of vap2 from crotalus atrox venom (form 2-2 crystal) 23 d1k7ia2 not modelled 82.4 13 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 24 d2i47a1 not modelled 82.2 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:TNF-alpha converting enzyme, TACE, catalytic domain 25 c2erpA_ not modelled 81.6 36 PDB header:toxin Chain: A: PDB Molecule:vascular apoptosis-inducing protein 1; PDBTitle: crystal structure of vascular apoptosis-inducing protein-1(inhibitor-2 bound form) 26 c2e3xA_ not modelled 81.5 36 PDB header:hydrolase, blood clotting, toxin Chain: A: PDB Molecule:coagulation factor x-activating enzyme heavy chain; PDBTitle: crystal structure of russell's viper venom metalloproteinase 27 d1bqqm_ not modelled 81.4 15 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 28 d4aiga_ not modelled 81.0 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 29 c3k7nA_ not modelled 81.0 36 PDB header:hydrolase Chain: A: PDB Molecule:k-like; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins 30 d1quaa_ not modelled 80.7 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 31 d1atla_ not modelled 80.6 43 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 32 c2i47A_ not modelled 80.4 33 PDB header:hydrolase Chain: A: PDB Molecule:adam 17; PDBTitle: crystal structure of catalytic domain of tace with inhibitor 33 c2jsdA_ not modelled 80.3 15 PDB header:hydrolase Chain: A: PDB Molecule:matrix metalloproteinase-20; PDBTitle: solution structure of mmp20 complexed with nngh 34 d1wnia_ not modelled 80.1 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 35 c1eakA_ not modelled 80.1 22 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:72 kda type iv collagenase; PDBTitle: catalytic domain of prommp-2 e404q mutant 36 c2qr4B_ not modelled 79.8 38 PDB header:hydrolase Chain: B: PDB Molecule:peptidase m3b, oligoendopeptidase f; PDBTitle: crystal structure of oligoendopeptidase-f from enterococcus faecium 37 d1nd1a_ not modelled 79.4 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 38 d1kufa_ not modelled 78.6 36 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 39 c2xs4A_ not modelled 77.5 18 PDB header:hydrolase Chain: A: PDB Molecule:karilysin protease; PDBTitle: structure of karilysin catalytic mmp domain in complex with2 magnesium 40 d1j36a_ not modelled 77.3 16 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 41 c1yp1A_ not modelled 76.5 43 PDB header:hydrolase Chain: A: PDB Molecule:fii; PDBTitle: crystal structure of a non-hemorrhagic fibrin(ogen)olytic2 metalloproteinase from venom of agkistrodon acutus 42 c3g5cA_ not modelled 76.4 11 PDB header:membrane protein Chain: A: PDB Molecule:adam 22; PDBTitle: structural and biochemical studies on the ectodomain of human adam22 43 d1c7ka_ not modelled 76.1 32 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Zinc protease 44 c2rjpC_ not modelled 76.0 31 PDB header:hydrolase Chain: C: PDB Molecule:adamts-4; PDBTitle: crystal structure of adamts4 with inhibitor bound 45 d2ajfa1 not modelled 75.6 18 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 46 d1bswa_ not modelled 75.4 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Reprolysin-like 47 c2rjqA_ not modelled 75.1 38 PDB header:hydrolase Chain: A: PDB Molecule:adamts-5; PDBTitle: crystal structure of adamts5 with inhibitor bound 48 c2v4bB_ not modelled 74.2 38 PDB header:hydrolase Chain: B: PDB Molecule:adamts-1; PDBTitle: crystal structure of human adamts-1 catalytic domain and2 cysteine-rich domain (apo-form) 49 d1uzea_ not modelled 73.9 22 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 50 c3zukB_ not modelled 73.0 12 PDB header:hydrolase/inhibitor Chain: B: PDB Molecule:endopeptidase, peptidase family m13; PDBTitle: crystal structure of mycobacterium tuberculosis zinc metalloprotease2 zmp1 in complex with inhibitor 51 c3p24C_ not modelled 72.7 53 PDB header:hydrolase Chain: C: PDB Molecule:bft-3; PDBTitle: structure of profragilysin-3 from bacteroides fragilis 52 c2c6nA_ not modelled 72.5 27 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:angiotensin-converting enzyme, somatic isoform; PDBTitle: structure of human somatic angiontensin-i converting enzyme n domain2 with lisinopril 53 c3b8zB_ not modelled 72.3 38 PDB header:hydrolase Chain: B: PDB Molecule:protein adamts-5; PDBTitle: high resolution crystal structure of the catalytic domain2 of adamts-5 (aggrecanase-2) 54 c3mdjB_ 71.3 20 PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: er aminopeptidase, erap1, bound to the zinc aminopeptidase inhibitor,2 bestatin 55 c3qnfA_ not modelled 71.0 22 PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: crystal structure of the open state of human endoplasmic reticulum2 aminopeptidase 1 erap1 56 d1xuca1 not modelled 69.3 46 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 57 c2gtqA_ not modelled 68.8 18 PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of aminopeptidase n from human pathogen neisseria2 meningitidis 58 c2j83B_ not modelled 68.7 40 PDB header:hydrolase Chain: B: PDB Molecule:ulilysin; PDBTitle: ulilysin metalloprotease in complex with batimastat. 59 d1cxva_ not modelled 68.5 46 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 60 c3o0yC_ not modelled 68.4 27 PDB header:lipid binding protein Chain: C: PDB Molecule:lipoprotein; PDBTitle: the crystal structure of the putative lipoprotein from colwellia2 psychrerythraea 61 d1rm8a_ not modelled 68.2 38 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 62 d1y93a1 not modelled 67.9 31 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 63 d1q3aa_ not modelled 66.7 46 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 64 c2cltB_ not modelled 66.7 38 PDB header:hydrolase Chain: B: PDB Molecule:interstitial collagenase; PDBTitle: crystal structure of the active form (full-length) of human2 fibroblast collagenase. 65 d1i76a_ not modelled 66.6 46 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 66 d1sata2 not modelled 66.5 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 67 d1mmqa_ not modelled 66.1 38 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 68 c3se6A_ not modelled 66.1 23 PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 2; PDBTitle: crystal structure of the human endoplasmic reticulum aminopeptidase 2 69 c1slmA_ not modelled 66.0 20 PDB header:hydrolase Chain: A: PDB Molecule:stromelysin-1; PDBTitle: crystal structure of fibroblast stromelysin-1: the c-truncated human2 proenzyme 70 d1g9ka2 not modelled 65.9 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 71 d1hfca_ not modelled 65.5 46 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 72 c1pwqA_ not modelled 65.3 21 PDB header:hydrolase Chain: A: PDB Molecule:lethal factor; PDBTitle: crystal structure of anthrax lethal factor complexed with2 thioacetyl-tyr-pro-met-amide, a metal-chelating peptidyl3 small molecule inhibitor 73 c1wgzC_ not modelled 65.0 24 PDB header:hydrolase Chain: C: PDB Molecule:carboxypeptidase 1; PDBTitle: crystal structure of carboxypeptidase 1 from thermus thermophilus 74 d1hv5a_ not modelled 64.8 55 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 75 d1hy7a_ not modelled 63.1 46 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 76 d2ovxa1 not modelled 63.1 38 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 77 d1qiba_ not modelled 62.2 46 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 78 d1cgla_ not modelled 61.6 46 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 79 c3ba0A_ not modelled 61.5 36 PDB header:hydrolase Chain: A: PDB Molecule:macrophage metalloelastase; PDBTitle: crystal structure of full-length human mmp-12 80 c2l0rA_ not modelled 59.1 40 PDB header:hydrolase,toxin Chain: A: PDB Molecule:lethal factor; PDBTitle: conformational dynamics of the anthrax lethal factor catalytic center 81 d1kapp2 not modelled 59.1 33 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Serralysin-like metalloprotease, catalytic (N-terminal) domain 82 c1su3A_ not modelled 57.6 50 PDB header:hydrolase Chain: A: PDB Molecule:interstitial collagenase; PDBTitle: x-ray structure of human prommp-1: new insights into2 collagenase action 83 c1jiwP_ not modelled 56.4 33 PDB header:hydrolase/hyrolase inhibitor Chain: P: PDB Molecule:alkaline metalloproteinase; PDBTitle: crystal structure of the apr-aprin complex 84 d1hova_ not modelled 56.2 46 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 85 d1eaka2 not modelled 54.7 38 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 86 c3hq2A_ not modelled 53.4 14 PDB header:hydrolase Chain: A: PDB Molecule:bacillus subtilis m32 carboxypeptidase; PDBTitle: bsucp crystal structure 87 c3iukB_ not modelled 53.2 11 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of putative bacterial protein of unknown function2 (duf885, pf05960.1, ) from arthrobacter aurescens tc1, reveals fold3 similar to that of m32 carboxypeptidases 88 d1k9xa_ not modelled 53.2 20 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Neurolysin-like 89 d1j7na2 not modelled 53.2 38 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Anthrax toxin lethal factor, N- and C-terminal domains 90 d1fbla2 not modelled 52.8 46 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Matrix metalloproteases, catalytic domain 91 c2xdtA_ not modelled 51.6 16 PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: crystal structure of the soluble domain of human2 endoplasmic reticulum aminopeptidase 1 erap1 92 c3b37A_ not modelled 51.5 18 PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of e. coli aminopeptidase n in complex with tyrosine 93 c1l6jA_ not modelled 51.3 50 PDB header:hydrolase Chain: A: PDB Molecule:matrix metalloproteinase-9; PDBTitle: crystal structure of human matrix metalloproteinase mmp92 (gelatinase b). 94 c1gxdA_ not modelled 48.6 23 PDB header:hydrolase Chain: A: PDB Molecule:72 kda type iv collagenase; PDBTitle: prommp-2/timp-2 complex 95 c3gabC_ not modelled 46.6 29 PDB header:hydrolase Chain: C: PDB Molecule:dna mismatch repair protein mutl; PDBTitle: c-terminal domain of bacillus subtilis mutl crystal form i 96 c1om8A_ not modelled 46.6 33 PDB header:hydrolase Chain: A: PDB Molecule:serralysin; PDBTitle: crystal structure of a cold adapted alkaline protease from pseudomonas2 tac ii 18, co-crystallyzed with 10 mm edta 97 d1asta_ not modelled 43.1 40 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Astacin 98 c3iabA_ not modelled 39.9 46 PDB header:hydrolase/rna Chain: A: PDB Molecule:ribonucleases p/mrp protein subunit pop6; PDBTitle: crystal structure of rnase p /rnase mrp proteins pop6, pop72 in a complex with the p3 domain of rnase mrp rna 99 c3lqbA_ not modelled 39.0 25 PDB header:hydrolase Chain: A: PDB Molecule:loc792177 protein; PDBTitle: crystal structure of the hatching enzyme zhe1 from the zebrafish danio2 rerio 100 c1yqyA_ not modelled 37.6 21 PDB header:hydrolase Chain: A: PDB Molecule:lethal factor; PDBTitle: structure of b. anthrax lethal factor in complex with a2 hydroxamate inhibitor 101 c1satA_ not modelled 36.7 16 PDB header:hydrolase (serine protease) Chain: A: PDB Molecule:serratia protease; PDBTitle: crystal structure of the 50 kda metallo protease from s.2 marcescens 102 c3edhA_ not modelled 36.6 50 PDB header:hydrolase Chain: A: PDB Molecule:bone morphogenetic protein 1; PDBTitle: crystal structure of bone morphogenetic protein 1 protease2 domain in complex with partially bound dmso 103 c3dwcA_ not modelled 32.7 16 PDB header:hydrolase Chain: A: PDB Molecule:metallocarboxypeptidase; PDBTitle: trypanosoma cruzi metallocarboxypeptidase 1 104 c3p1vB_ not modelled 32.3 38 PDB header:hydrolase Chain: B: PDB Molecule:metallo-endopeptidase; PDBTitle: crystal structure of a metallo-endopeptidases (bacova_00663) from2 bacteroides ovatus at 1.93 a resolution 105 c3ncvB_ not modelled 32.1 8 PDB header:hydrolase Chain: B: PDB Molecule:dna mismatch repair protein mutl; PDBTitle: ngol 106 c3ebhA_ not modelled 32.0 36 PDB header:hydrolase inhibitor Chain: A: PDB Molecule:m1 family aminopeptidase; PDBTitle: structure of the m1 alanylaminopeptidase from malaria complexed with2 bestatin 107 c3lq0A_ not modelled 28.5 30 PDB header:hydrolase Chain: A: PDB Molecule:proastacin; PDBTitle: zymogen structure of crayfish astacin metallopeptidase 108 c1z5hB_ not modelled 27.9 40 PDB header:hydrolase Chain: B: PDB Molecule:tricorn protease interacting factor f3; PDBTitle: crystal structures of the tricorn interacting factor f32 from thermoplasma acidophilum 109 c3b7uX_ not modelled 27.8 21 PDB header:hydrolase Chain: X: PDB Molecule:leukotriene a-4 hydrolase; PDBTitle: leukotriene a4 hydrolase complexed with kelatorphan 110 c3b4rB_ not modelled 26.8 33 PDB header:hydrolase Chain: B: PDB Molecule:putative zinc metalloprotease mj0392; PDBTitle: site-2 protease from methanocaldococcus jannaschii 111 c3ciaA_ not modelled 26.0 17 PDB header:hydrolase Chain: A: PDB Molecule:cold-active aminopeptidase; PDBTitle: crystal structure of cold-aminopeptidase from colwellia2 psychrerythraea 112 d3e11a1 not modelled 23.9 44 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:TTHA0227-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0