Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	S	L	I	A	A	L	A	V	D	R	V	I	G	M	E	N	A	M	P	W	N	L	P	A	D	L	A	W	F	K	R	N	T	L	N	K	P	V	I	M	G	R	H	T	W	E	S	I	G	R	P	L	P	G	R	K	N	I
Secondary structure
SS confidence
Disorder		?															?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	L	S	S	Q	P	G	T	D	D	R	V	T	W	V	K	S	V	D	E	A	I	A	A	C	G	D	V	P	E	I	M	V	I	G	G	G	R	V	Y	E	Q	F	L	P	K	A	Q	K	L	Y	L	T	H	I	D	A	E	V	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.
Sequence		G	D	T	H	F	P	D	Y	E	P	D	D	W	E	S	V	F	S	E	F	H	D	A	D	A	Q	N	S	H	S	Y	C	F	E	I	L	E	R	R
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?	?	?														?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1ra9 chain A Region: 1 - 159 Aligned: 159 Modelled: 159 Confidence: 100.0% Identity: 99% Fold: Dihydrofolate reductase-like Superfamily: Dihydrofolate reductase-like Family: Dihydrofolate reductases Phyre2 PDB 3tq8 chain A Region: 1 - 159 Aligned: 157 Modelled: 159 Confidence: 100.0% Identity: 43% PDB header:oxidoreductase/oxidoreductase inhibitor Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: structure of the dihydrofolate reductase (fola) from coxiella burnetii2 in complex with trimethoprim Phyre2 PDB 3ia5 chain A Region: 1 - 158 Aligned: 157 Modelled: 158 Confidence: 100.0% Identity: 55% PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: moritella profunda dihydrofolate reductase (dhfr) Phyre2 PDB 3e0b chain A Region: 2 - 159 Aligned: 158 Modelled: 158 Confidence: 100.0% Identity: 40% PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: bacillus anthracis dihydrofolate reductase complexed with2 nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-3 ynyl)-6-ethylpyrimidine (ucp120b) Phyre2 PDB 3f0u chain X Region: 2 - 159 Aligned: 155 Modelled: 158 Confidence: 100.0% Identity: 35% PDB header:oxidoreductase Chain: X: PDB Molecule:trimethoprim-sensitive dihydrofolate reductase; PDBTitle: staphylococcus aureus f98y mutant dihydrofolate reductase2 complexed with nadph and 2,4-diamino-5-[3-(3-methoxy-5-3 phenylphenyl)but-1-ynyl]-6-methylpyrimidine Phyre2 PDB 1zdr chain B Region: 1 - 158 Aligned: 158 Modelled: 158 Confidence: 100.0% Identity: 39% PDB header:oxidoreductase Chain: B: PDB Molecule:dihydrofolate reductase; PDBTitle: dhfr from bacillus stearothermophilus Phyre2 PDB 3k2h chain A Region: 2 - 159 Aligned: 155 Modelled: 158 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: A: PDB Molecule:dihydrofolate reductase/thymidylate synthase; PDBTitle: co-crystal structure of dihydrofolate reductase/thymidylate synthase2 from babesia bovis with dump, pemetrexed and nadp Phyre2 PDB 2oip chain E Region: 1 - 159 Aligned: 156 Modelled: 159 Confidence: 100.0% Identity: 34% PDB header:transferase, oxidoreductase Chain: E: PDB Molecule:chain a, crystal structure of dhfr; PDBTitle: crystal structure of the s290g active site mutant of ts-2 dhfr from cryptosporidium hominis Phyre2 PDB 3dfr chain A Region: 3 - 159 Aligned: 156 Modelled: 157 Confidence: 100.0% Identity: 28% Fold: Dihydrofolate reductase-like Superfamily: Dihydrofolate reductase-like Family: Dihydrofolate reductases Phyre2 PDB 3cse chain A Region: 1 - 159 Aligned: 159 Modelled: 159 Confidence: 100.0% Identity: 30% PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: candida glabrata dihydrofolate reductase complexed with2 nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-3 ynyl)-6-ethylpyrimidine (ucp120b) Phyre2 PDB 3ix9 chain B Region: 1 - 159 Aligned: 159 Modelled: 159 Confidence: 100.0% Identity: 35% PDB header:oxidoreductase Chain: B: PDB Molecule:dihydrofolate reductase; PDBTitle: crystal structure of streptococcus pneumoniae dihydrofolate2 reductase - sp9 mutant Phyre2 PDB 8dfr chain A Region: 2 - 159 Aligned: 158 Modelled: 158 Confidence: 100.0% Identity: 32% Fold: Dihydrofolate reductase-like Superfamily: Dihydrofolate reductase-like Family: Dihydrofolate reductases Phyre2 PDB 1aoe chain A Region: 1 - 159 Aligned: 158 Modelled: 158 Confidence: 100.0% Identity: 35% Fold: Dihydrofolate reductase-like Superfamily: Dihydrofolate reductase-like Family: Dihydrofolate reductases Phyre2 PDB 3jsu chain A Region: 2 - 159 Aligned: 156 Modelled: 158 Confidence: 100.0% Identity: 35% PDB header:oxidoreductase, transferase Chain: A: PDB Molecule:dihydrofolate reductase-thymidylate synthase; PDBTitle: quadruple mutant(n51i+c59r+s108n+i164l) plasmodium falciparum2 dihydrofolate reductase-thymidylate synthase(pfdhfr-ts) complexed3 with qn254, nadph, and dump Phyre2 PDB 1kmv chain A Region: 2 - 158 Aligned: 157 Modelled: 157 Confidence: 100.0% Identity: 32% Fold: Dihydrofolate reductase-like Superfamily: Dihydrofolate reductase-like Family: Dihydrofolate reductases Phyre2 PDB 1j3k chain A Region: 2 - 159 Aligned: 156 Modelled: 158 Confidence: 100.0% Identity: 35% Fold: Dihydrofolate reductase-like Superfamily: Dihydrofolate reductase-like Family: Dihydrofolate reductases Phyre2 PDB 2fzi chain A domain 1 Region: 2 - 159 Aligned: 158 Modelled: 158 Confidence: 100.0% Identity: 35% Fold: Dihydrofolate reductase-like Superfamily: Dihydrofolate reductase-like Family: Dihydrofolate reductases Phyre2 PDB 3dg8 chain B Region: 2 - 159 Aligned: 156 Modelled: 158 Confidence: 100.0% Identity: 35% PDB header:oxidoreductase, transferase Chain: B: PDB Molecule:bifunctional dihydrofolate reductase-thymidylate PDBTitle: quadruple mutant (n51i+c59r+s108n+i164l) plasmodium2 falciparum dihydrofolate reductase-thymidylate synthase3 (pfdhfr-ts) complexed with rjf670, nadph, and dump Phyre2 PDB 3rg9 chain A Region: 1 - 159 Aligned: 159 Modelled: 159 Confidence: 100.0% Identity: 32% PDB header:oxidoreductase/oxidoreductase inhibitor Chain: A: PDB Molecule:bifunctional dihydrofolate reductase-thymidylate synthase; PDBTitle: trypanosoma brucei dihydrofolate reductase (tbdhfr) in complex with2 wr99210 Phyre2 PDB 1df7 chain A Region: 1 - 158 Aligned: 151 Modelled: 158 Confidence: 100.0% Identity: 36% Fold: Dihydrofolate reductase-like Superfamily: Dihydrofolate reductase-like Family: Dihydrofolate reductases Phyre2 1 d1ra9a_ 2 c3tq8A_ 3 c3ia5A_ 4 c3e0bA_ 5 c3f0uX_ 6 c1zdrB_ 7 c3k2hA_ 8 c2oipE_ 9 d3dfra_ 10 c3cseA_ 11 c3ix9B_ 12 d8dfra_ 13 d1aoea_ 14 c3jsuA_ 15 d1kmva_ 16 d1j3ka_ 17 d2fzia1 18 c3dg8B_ 19 c3rg9A_ 20 d1df7a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1ra9a_ 100.0 99 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 2 c3tq8A_ 100.0 43 PDB header:oxidoreductase/oxidoreductase inhibitor Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: structure of the dihydrofolate reductase (fola) from coxiella burnetii2 in complex with trimethoprim 3 c3ia5A_ 100.0 55 PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: moritella profunda dihydrofolate reductase (dhfr) 4 c3e0bA_ 100.0 40 PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: bacillus anthracis dihydrofolate reductase complexed with2 nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-3 ynyl)-6-ethylpyrimidine (ucp120b) 5 c3f0uX_ 100.0 35 PDB header:oxidoreductase Chain: X: PDB Molecule:trimethoprim-sensitive dihydrofolate reductase; PDBTitle: staphylococcus aureus f98y mutant dihydrofolate reductase2 complexed with nadph and 2,4-diamino-5-[3-(3-methoxy-5-3 phenylphenyl)but-1-ynyl]-6-methylpyrimidine 6 c1zdrB_ 100.0 39 PDB header:oxidoreductase Chain: B: PDB Molecule:dihydrofolate reductase; PDBTitle: dhfr from bacillus stearothermophilus 7 c3k2hA_ 100.0 34 PDB header:transferase Chain: A: PDB Molecule:dihydrofolate reductase/thymidylate synthase; PDBTitle: co-crystal structure of dihydrofolate reductase/thymidylate synthase2 from babesia bovis with dump, pemetrexed and nadp 8 c2oipE_ 100.0 34 PDB header:transferase, oxidoreductase Chain: E: PDB Molecule:chain a, crystal structure of dhfr; PDBTitle: crystal structure of the s290g active site mutant of ts-2 dhfr from cryptosporidium hominis 9 d3dfra_ 100.0 28 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 10 c3cseA_ 100.0 30 PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: candida glabrata dihydrofolate reductase complexed with2 nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-3 ynyl)-6-ethylpyrimidine (ucp120b) 11 c3ix9B_ 100.0 35 PDB header:oxidoreductase Chain: B: PDB Molecule:dihydrofolate reductase; PDBTitle: crystal structure of streptococcus pneumoniae dihydrofolate2 reductase - sp9 mutant 12 d8dfra_ 100.0 32 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 13 d1aoea_ 100.0 35 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 14 c3jsuA_ 100.0 35 PDB header:oxidoreductase, transferase Chain: A: PDB Molecule:dihydrofolate reductase-thymidylate synthase; PDBTitle: quadruple mutant(n51i+c59r+s108n+i164l) plasmodium falciparum2 dihydrofolate reductase-thymidylate synthase(pfdhfr-ts) complexed3 with qn254, nadph, and dump 15 d1kmva_ 100.0 32 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 16 d1j3ka_ 100.0 35 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 17 d2fzia1 100.0 35 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 18 c3dg8B_ 100.0 35 PDB header:oxidoreductase, transferase Chain: B: PDB Molecule:bifunctional dihydrofolate reductase-thymidylate PDBTitle: quadruple mutant (n51i+c59r+s108n+i164l) plasmodium2 falciparum dihydrofolate reductase-thymidylate synthase3 (pfdhfr-ts) complexed with rjf670, nadph, and dump 19 c3rg9A_ 100.0 32 PDB header:oxidoreductase/oxidoreductase inhibitor Chain: A: PDB Molecule:bifunctional dihydrofolate reductase-thymidylate synthase; PDBTitle: trypanosoma brucei dihydrofolate reductase (tbdhfr) in complex with2 wr99210 20 d1df7a_ 100.0 36 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 21 c2blcA_ not modelled 100.0 29 PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase-thymidylate synthase; PDBTitle: sp21 double mutant p. vivax dihydrofolate reductase in2 complex with des-chloropyrimethamine 22 d1vdra_ not modelled 100.0 33 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 23 c3clbA_ not modelled 100.0 37 PDB header:oxidoreductase, transferase Chain: A: PDB Molecule:dhfr-ts; PDBTitle: structure of bifunctional tcdhfr-ts in complex with tmq 24 d1seja1 not modelled 100.0 33 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 25 d1juva_ not modelled 100.0 22 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 26 d1d1ga_ not modelled 100.0 26 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 27 c3jtwB_ not modelled 99.9 19 PDB header:oxidoreductase Chain: B: PDB Molecule:dihydrofolate reductase; PDBTitle: crystal structure of putative dihydrofolate reductase (yp_805003.1)2 from pediococcus pentosaceus atcc 25745 at 1.90 a resolution 28 c2gd9A_ not modelled 99.8 17 PDB header:oxidoreductase Chain: A: PDB Molecule:hypothetical protein yyap; PDBTitle: crystal structure of a putative dihydrofolate reductase (bsu40760,2 yyap) from bacillus subtilis at 2.30 a resolution 29 c2xw7A_ not modelled 99.8 16 PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: structure of mycobacterium smegmatis putative reductase ms0308 30 c3ky8B_ not modelled 99.6 18 PDB header:biosynthetic protein Chain: B: PDB Molecule:putative riboflavin biosynthesis protein; PDBTitle: crystal structure of putative riboflavin biosynthesis protein2 (yp_001092907.1) from shewanella sp. pv-4 at 2.12 a resolution 31 d2hxva1 not modelled 99.5 20 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:RibD C-terminal domain-like 32 c3kgyA_ not modelled 99.4 19 PDB header:oxidoreductase Chain: A: PDB Molecule:bifunctional deaminase-reductase domain protein; PDBTitle: crystal structure of putative dihydrofolate reductase (yp_001636057.1)2 from chloroflexus aurantiacus j-10-fl at 1.50 a resolution 33 d2azna1 not modelled 99.4 16 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:RibD C-terminal domain-like 34 d2b3za1 not modelled 99.4 15 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:RibD C-terminal domain-like 35 c2hxvA_ not modelled 99.3 20 PDB header:biosynthetic protein Chain: A: PDB Molecule:diaminohydroxyphosphoribosylaminopyrimidine deaminase/ 5- PDBTitle: crystal structure of a diaminohydroxyphosphoribosylaminopyrimidine2 deaminase/ 5-amino-6-(5-phosphoribosylamino)uracil reductase (tm1828)3 from thermotoga maritima at 1.80 a resolution 36 c2o7pA_ not modelled 99.2 15 PDB header:hydrolase, oxidoreductase Chain: A: PDB Molecule:riboflavin biosynthesis protein ribd; PDBTitle: the crystal structure of ribd from escherichia coli in complex with2 the oxidised nadp+ cofactor in the active site of the reductase3 domain 37 c2d5nB_ not modelled 99.2 16 PDB header:hydrolase, oxidoreductase Chain: B: PDB Molecule:riboflavin biosynthesis protein ribd; PDBTitle: crystal structure of a bifunctional deaminase and reductase2 involved in riboflavin biosynthesis 38 c2p4gA_ not modelled 98.8 17 PDB header:oxidoreductase Chain: A: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of a pyrimidine reductase-like protein (dip1392)2 from corynebacterium diphtheriae nctc at 2.30 a resolution 39 d1aoga2 not modelled 66.2 13 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 40 d1q1ra2 not modelled 47.6 19 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 41 d1gesa2 not modelled 38.5 21 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 42 d1gera2 not modelled 33.9 18 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 43 d3grsa2 not modelled 32.9 10 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 44 d1onfa2 not modelled 28.4 17 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 45 d1m6ia2 not modelled 27.4 27 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 46 d1feca2 not modelled 22.3 17 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 47 d1nhpa2 not modelled 21.2 27 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 48 d1gv4a2 not modelled 20.3 33 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 49 c3fq6A_ not modelled 20.1 17 PDB header:transferase Chain: A: PDB Molecule:methyltransferase; PDBTitle: the crystal structure of a methyltransferase domain from bacteroides2 thetaiotaomicron vpi 50 d1h6va2 not modelled 18.3 15 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 51 c3ihtB_ not modelled 16.7 11 PDB header:transferase Chain: B: PDB Molecule:s-adenosyl-l-methionine methyl transferase; PDBTitle: crystal structure of s-adenosyl-l-methionine methyl transferase2 (yp_165822.1) from silicibacter pomeroyi dss-3 at 1.80 a resolution 52 d1rm6b2 not modelled 16.2 11 Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CO dehydrogenase flavoprotein N-terminal domain-like 53 d1udxa3 not modelled 15.8 18 Fold:Obg GTP-binding protein C-terminal domain Superfamily:Obg GTP-binding protein C-terminal domain Family:Obg GTP-binding protein C-terminal domain 54 c3q3vA_ not modelled 15.7 13 PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of phosphoglycerate kinase from campylobacter2 jejuni. 55 c1jb9A_ not modelled 15.1 16 PDB header:oxidoreductase Chain: A: PDB Molecule:ferredoxin-nadp reductase; PDBTitle: crystal structure of the ferredoxin:nadp+ reductase from maize root at2 1.7 angstroms 56 c1zmrA_ not modelled 14.3 18 PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of the e. coli phosphoglycerate kinase 57 d1d7ya2 not modelled 14.0 18 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 58 d1vjda_ not modelled 13.9 17 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 59 d1hdia_ not modelled 13.5 20 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 60 d1fw8a_ not modelled 13.3 17 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 61 d1vdca2 not modelled 13.2 22 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 62 c3cqyA_ not modelled 12.5 30 PDB header:transferase Chain: A: PDB Molecule:anhydro-n-acetylmuramic acid kinase; PDBTitle: crystal structure of a functionally unknown protein (so_1313) from2 shewanella oneidensis mr-1 63 d1ojta2 not modelled 11.8 18 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 64 c1rm6E_ not modelled 11.7 11 PDB header:oxidoreductase Chain: E: PDB Molecule:4-hydroxybenzoyl-coa reductase beta subunit; PDBTitle: structure of 4-hydroxybenzoyl-coa reductase from thauera2 aromatica 65 d1qpga_ not modelled 11.5 21 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 66 d1ebda2 not modelled 11.3 20 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 67 d2b4ya1 not modelled 11.1 20 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 68 d1lvla2 not modelled 11.1 30 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 69 c3okfA_ not modelled 10.9 11 PDB header:lyase Chain: A: PDB Molecule:3-dehydroquinate synthase; PDBTitle: 2.5 angstrom resolution crystal structure of 3-dehydroquinate synthase2 (arob) from vibrio cholerae 70 d1jeoa_ not modelled 10.7 27 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 71 d1gg4a1 not modelled 10.5 21 Fold:MurD-like peptide ligases, peptide-binding domain Superfamily:MurD-like peptide ligases, peptide-binding domain Family:MurCDEF C-terminal domain 72 d1ltka_ not modelled 10.3 17 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 73 d1dxla2 not modelled 9.0 26 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 74 d16pka_ not modelled 8.7 17 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 75 d1xhca2 not modelled 8.5 19 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 76 d1phpa_ not modelled 8.5 26 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 77 c2jraB_ not modelled 8.5 28 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:protein rpa2121; PDBTitle: a novel domain-swapped solution nmr structure of protein rpa2121 from2 rhodopseudomonas palustris. northeast structural genomics target rpt6 78 d1vpea_ not modelled 8.4 21 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 79 d2gs5a1 not modelled 8.1 12 Fold:VC0467-like Superfamily:VC0467-like Family:VC0467-like 80 c2hjhB_ not modelled 8.1 23 PDB header:hydrolase Chain: B: PDB Molecule:nad-dependent histone deacetylase sir2; PDBTitle: crystal structure of the sir2 deacetylase 81 c1xahA_ not modelled 8.0 9 PDB header:lyase Chain: A: PDB Molecule:3-dehydroquinate synthase; PDBTitle: crystal structure of staphlyococcus aureus 3-dehydroquinate2 synthase (dhqs) in complex with zn2+ and nad+ 82 d1v6sa_ not modelled 7.8 19 Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase 83 d2i14a2 not modelled 7.7 20 Fold:alpha/beta-Hammerhead Superfamily:Nicotinate/Quinolinate PRTase N-terminal domain-like Family:NadC N-terminal domain-like 84 c2cunA_ not modelled 7.5 24 PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of phosphoglycerate kinase from pyrococcus2 horikoshii ot3 85 c3hl0B_ not modelled 7.3 20 PDB header:oxidoreductase Chain: B: PDB Molecule:maleylacetate reductase; PDBTitle: crystal structure of maleylacetate reductase from agrobacterium2 tumefaciens 86 c3ce9A_ not modelled 6.7 16 PDB header:oxidoreductase Chain: A: PDB Molecule:glycerol dehydrogenase; PDBTitle: crystal structure of glycerol dehydrogenase (np_348253.1) from2 clostridium acetobutylicum at 2.37 a resolution 87 c3f3mA_ not modelled 6.6 25 PDB header:transferase Chain: A: PDB Molecule:phosphopantetheine adenylyltransferase; PDBTitle: six crystal structures of two phosphopantetheine2 adenylyltransferases reveal an alternative ligand binding3 mode and an associated structural change 88 d1krha2 not modelled 6.5 13 Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:Aromatic dioxygenase reductase-like 89 c1kyqC_ not modelled 6.5 38 PDB header:oxidoreductase, lyase Chain: C: PDB Molecule:siroheme biosynthesis protein met8; PDBTitle: met8p: a bifunctional nad-dependent dehydrogenase and2 ferrochelatase involved in siroheme synthesis. 90 d1kyqa1 not modelled 6.4 38 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Siroheme synthase N-terminal domain-like 91 d2h3ka1 not modelled 6.3 17 Fold:Immunoglobulin-like beta-sandwich Superfamily:NEAT domain-like Family:NEAT domain 92 d1fcda1 not modelled 6.3 26 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 93 d1jb9a2 not modelled 6.3 16 Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:Reductases 94 c3dfzB_ not modelled 6.3 18 PDB header:oxidoreductase Chain: B: PDB Molecule:precorrin-2 dehydrogenase; PDBTitle: sirc, precorrin-2 dehydrogenase 95 d1fl2a2 not modelled 6.1 29 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains 96 c3hrdC_ not modelled 6.0 18 PDB header:oxidoreductase Chain: C: PDB Molecule:nicotinate dehydrogenase fad-subunit; PDBTitle: crystal structure of nicotinate dehydrogenase 97 d1ddga2 not modelled 6.0 22 Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:NADPH-cytochrome p450 reductase-like 98 d1up7a1 not modelled 5.8 43 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like 99 d1v59a2 not modelled 5.8 24 Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0