Phyre 2 Results for P0ABQ4

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Email | l.a.kelley@imperial.ac.uk
Description | P0ABQ4
Date | Thu Jan 5 11:16:05 GMT 2012
Unique Job ID | 6bc08d06dbd532de

Summary |

Top model
Image coloured by rainbow N → C terminus
| Close Jmol

Model (left) based on template d1ra9a_
Top template information
Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases
Confidence and coverage
Confidence: | 100.0% | Coverage: | 100%
159 residues (100% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | I | S | L | I | A | A | L | A | V | D | R | V | I | G | M | E | N | A | M | P | W | N | L | P | A | D | L | A | W | F | K | R | N | T | L | N | K | P | V | I | M | G | R | H | T | W | E | S | I | G | R | P | L | P | G | R | K | N | I
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | I | L | S | S | Q | P | G | T | D | D | R | V | T | W | V | K | S | V | D | E | A | I | A | A | C | G | D | V | P | E | I | M | V | I | G | G | G | R | V | Y | E | Q | F | L | P | K | A | Q | K | L | Y | L | T | H | I | D | A | E | V | E
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | .
Sequence |  | G | D | T | H | F | P | D | Y | E | P | D | D | W | E | S | V | F | S | E | F | H | D | A | D | A | Q | N | S | H | S | Y | C | F | E | I | L | E | R | R
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| d1ra9a_ |

### PDB 1ra9 chain A

Region: 1 - 159
Aligned: 159
Modelled: 159
Confidence: 100.0%
Identity: 99%
Fold: Dihydrofolate reductase-like
Superfamily: Dihydrofolate reductase-like
Family: Dihydrofolate reductases

Phyre2
2 |
| c3tq8A_ |

### PDB 3tq8 chain A

Region: 1 - 159
Aligned: 157
Modelled: 159
Confidence: 100.0%
Identity: 43%
PDB header:oxidoreductase/oxidoreductase inhibitor
Chain: A: PDB Molecule:dihydrofolate reductase;
PDBTitle: structure of the dihydrofolate reductase (fola) from coxiella burnetii2 in complex with trimethoprim

Phyre2
3 |
| c3ia5A_ |

### PDB 3ia5 chain A

Region: 1 - 158
Aligned: 157
Modelled: 158
Confidence: 100.0%
Identity: 55%
PDB header:oxidoreductase
Chain: A: PDB Molecule:dihydrofolate reductase;
PDBTitle: moritella profunda dihydrofolate reductase (dhfr)

Phyre2
4 |
| c3e0bA_ |

### PDB 3e0b chain A

Region: 2 - 159
Aligned: 158
Modelled: 158
Confidence: 100.0%
Identity: 40%
PDB header:oxidoreductase
Chain: A: PDB Molecule:dihydrofolate reductase;
PDBTitle: bacillus anthracis dihydrofolate reductase complexed with2 nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-3 ynyl)-6-ethylpyrimidine (ucp120b)

Phyre2
5 |
| c3f0uX_ |

### PDB 3f0u chain X

Region: 2 - 159
Aligned: 155
Modelled: 158
Confidence: 100.0%
Identity: 35%
PDB header:oxidoreductase
Chain: X: PDB Molecule:trimethoprim-sensitive dihydrofolate reductase;
PDBTitle: staphylococcus aureus f98y mutant dihydrofolate reductase2 complexed with nadph and 2,4-diamino-5-[3-(3-methoxy-5-3 phenylphenyl)but-1-ynyl]-6-methylpyrimidine

Phyre2
6 |
| c1zdrB_ |

### PDB 1zdr chain B

Region: 1 - 158
Aligned: 158
Modelled: 158
Confidence: 100.0%
Identity: 39%
PDB header:oxidoreductase
Chain: B: PDB Molecule:dihydrofolate reductase;
PDBTitle: dhfr from bacillus stearothermophilus

Phyre2
7 |
| c3k2hA_ |

### PDB 3k2h chain A

Region: 2 - 159
Aligned: 155
Modelled: 158
Confidence: 100.0%
Identity: 34%
PDB header:transferase
Chain: A: PDB Molecule:dihydrofolate reductase/thymidylate synthase;
PDBTitle: co-crystal structure of dihydrofolate reductase/thymidylate synthase2 from babesia bovis with dump, pemetrexed and nadp

Phyre2
8 |
| c2oipE_ |

### PDB 2oip chain E

Region: 1 - 159
Aligned: 156
Modelled: 159
Confidence: 100.0%
Identity: 34%
PDB header:transferase, oxidoreductase
Chain: E: PDB Molecule:chain a, crystal structure of dhfr;
PDBTitle: crystal structure of the s290g active site mutant of ts-2 dhfr from cryptosporidium hominis

Phyre2
9 |
| d3dfra_ |

### PDB 3dfr chain A

Region: 3 - 159
Aligned: 156
Modelled: 157
Confidence: 100.0%
Identity: 28%
Fold: Dihydrofolate reductase-like
Superfamily: Dihydrofolate reductase-like
Family: Dihydrofolate reductases

Phyre2
10 |
| c3cseA_ |

### PDB 3cse chain A

Region: 1 - 159
Aligned: 159
Modelled: 159
Confidence: 100.0%
Identity: 30%
PDB header:oxidoreductase
Chain: A: PDB Molecule:dihydrofolate reductase;
PDBTitle: candida glabrata dihydrofolate reductase complexed with2 nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-3 ynyl)-6-ethylpyrimidine (ucp120b)

Phyre2
11 |
| c3ix9B_ |

### PDB 3ix9 chain B

Region: 1 - 159
Aligned: 159
Modelled: 159
Confidence: 100.0%
Identity: 35%
PDB header:oxidoreductase
Chain: B: PDB Molecule:dihydrofolate reductase;
PDBTitle: crystal structure of streptococcus pneumoniae dihydrofolate2 reductase - sp9 mutant

Phyre2
12 |
| d8dfra_ |

### PDB 8dfr chain A

Region: 2 - 159
Aligned: 158
Modelled: 158
Confidence: 100.0%
Identity: 32%
Fold: Dihydrofolate reductase-like
Superfamily: Dihydrofolate reductase-like
Family: Dihydrofolate reductases

Phyre2
13 |
| d1aoea_ |

### PDB 1aoe chain A

Region: 1 - 159
Aligned: 158
Modelled: 158
Confidence: 100.0%
Identity: 35%
Fold: Dihydrofolate reductase-like
Superfamily: Dihydrofolate reductase-like
Family: Dihydrofolate reductases

Phyre2
14 |
| c3jsuA_ |

### PDB 3jsu chain A

Region: 2 - 159
Aligned: 156
Modelled: 158
Confidence: 100.0%
Identity: 35%
PDB header:oxidoreductase, transferase
Chain: A: PDB Molecule:dihydrofolate reductase-thymidylate synthase;
PDBTitle: quadruple mutant(n51i+c59r+s108n+i164l) plasmodium falciparum2 dihydrofolate reductase-thymidylate synthase(pfdhfr-ts) complexed3 with qn254, nadph, and dump

Phyre2
15 |
| d1kmva_ |

### PDB 1kmv chain A

Region: 2 - 158
Aligned: 157
Modelled: 157
Confidence: 100.0%
Identity: 32%
Fold: Dihydrofolate reductase-like
Superfamily: Dihydrofolate reductase-like
Family: Dihydrofolate reductases

Phyre2
16 |
| d1j3ka_ |

### PDB 1j3k chain A

Region: 2 - 159
Aligned: 156
Modelled: 158
Confidence: 100.0%
Identity: 35%
Fold: Dihydrofolate reductase-like
Superfamily: Dihydrofolate reductase-like
Family: Dihydrofolate reductases

Phyre2
17 |
| d2fzia1 |

### PDB 2fzi chain A domain 1

Region: 2 - 159
Aligned: 158
Modelled: 158
Confidence: 100.0%
Identity: 35%
Fold: Dihydrofolate reductase-like
Superfamily: Dihydrofolate reductase-like
Family: Dihydrofolate reductases

Phyre2
18 |
| c3dg8B_ |

### PDB 3dg8 chain B

Region: 2 - 159
Aligned: 156
Modelled: 158
Confidence: 100.0%
Identity: 35%
PDB header:oxidoreductase, transferase
Chain: B: PDB Molecule:bifunctional dihydrofolate reductase-thymidylate
PDBTitle: quadruple mutant (n51i+c59r+s108n+i164l) plasmodium2 falciparum dihydrofolate reductase-thymidylate synthase3 (pfdhfr-ts) complexed with rjf670, nadph, and dump

Phyre2
19 |
| c3rg9A_ |

### PDB 3rg9 chain A

Region: 1 - 159
Aligned: 159
Modelled: 159
Confidence: 100.0%
Identity: 32%
PDB header:oxidoreductase/oxidoreductase inhibitor
Chain: A: PDB Molecule:bifunctional dihydrofolate reductase-thymidylate synthase;
PDBTitle: trypanosoma brucei dihydrofolate reductase (tbdhfr) in complex with2 wr99210

Phyre2
20 |
| d1df7a_ |

### PDB 1df7 chain A

Region: 1 - 158
Aligned: 151
Modelled: 158
Confidence: 100.0%
Identity: 36%
Fold: Dihydrofolate reductase-like
Superfamily: Dihydrofolate reductase-like
Family: Dihydrofolate reductases

Phyre2
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Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | d1ra9a_ |
|  | 100.0 | 99 | Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases
2 | c3tq8A_ |
|  | 100.0 | 43 | PDB header:oxidoreductase/oxidoreductase inhibitor Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: structure of the dihydrofolate reductase (fola) from coxiella burnetii2 in complex with trimethoprim
3 | c3ia5A_ |
|  | 100.0 | 55 | PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: moritella profunda dihydrofolate reductase (dhfr)
4 | c3e0bA_ |
|  | 100.0 | 40 | PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: bacillus anthracis dihydrofolate reductase complexed with2 nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-3 ynyl)-6-ethylpyrimidine (ucp120b)
5 | c3f0uX_ |
|  | 100.0 | 35 | PDB header:oxidoreductase Chain: X: PDB Molecule:trimethoprim-sensitive dihydrofolate reductase; PDBTitle: staphylococcus aureus f98y mutant dihydrofolate reductase2 complexed with nadph and 2,4-diamino-5-[3-(3-methoxy-5-3 phenylphenyl)but-1-ynyl]-6-methylpyrimidine
6 | c1zdrB_ |
|  | 100.0 | 39 | PDB header:oxidoreductase Chain: B: PDB Molecule:dihydrofolate reductase; PDBTitle: dhfr from bacillus stearothermophilus
7 | c3k2hA_ |
|  | 100.0 | 34 | PDB header:transferase Chain: A: PDB Molecule:dihydrofolate reductase/thymidylate synthase; PDBTitle: co-crystal structure of dihydrofolate reductase/thymidylate synthase2 from babesia bovis with dump, pemetrexed and nadp
8 | c2oipE_ |
|  | 100.0 | 34 | PDB header:transferase, oxidoreductase Chain: E: PDB Molecule:chain a, crystal structure of dhfr; PDBTitle: crystal structure of the s290g active site mutant of ts-2 dhfr from cryptosporidium hominis
9 | d3dfra_ |
|  | 100.0 | 28 | Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases
10 | c3cseA_ |
|  | 100.0 | 30 | PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: candida glabrata dihydrofolate reductase complexed with2 nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-3 ynyl)-6-ethylpyrimidine (ucp120b)
11 | c3ix9B_ |
|  | 100.0 | 35 | PDB header:oxidoreductase Chain: B: PDB Molecule:dihydrofolate reductase; PDBTitle: crystal structure of streptococcus pneumoniae dihydrofolate2 reductase - sp9 mutant
12 | d8dfra_ |
|  | 100.0 | 32 | Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases
13 | d1aoea_ |
|  | 100.0 | 35 | Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases
14 | c3jsuA_ |
|  | 100.0 | 35 | PDB header:oxidoreductase, transferase Chain: A: PDB Molecule:dihydrofolate reductase-thymidylate synthase; PDBTitle: quadruple mutant(n51i+c59r+s108n+i164l) plasmodium falciparum2 dihydrofolate reductase-thymidylate synthase(pfdhfr-ts) complexed3 with qn254, nadph, and dump
15 | d1kmva_ |
|  | 100.0 | 32 | Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases
16 | d1j3ka_ |
|  | 100.0 | 35 | Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases
17 | d2fzia1 |
|  | 100.0 | 35 | Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases
18 | c3dg8B_ |
|  | 100.0 | 35 | PDB header:oxidoreductase, transferase Chain: B: PDB Molecule:bifunctional dihydrofolate reductase-thymidylate PDBTitle: quadruple mutant (n51i+c59r+s108n+i164l) plasmodium2 falciparum dihydrofolate reductase-thymidylate synthase3 (pfdhfr-ts) complexed with rjf670, nadph, and dump
19 | c3rg9A_ |
|  | 100.0 | 32 | PDB header:oxidoreductase/oxidoreductase inhibitor Chain: A: PDB Molecule:bifunctional dihydrofolate reductase-thymidylate synthase; PDBTitle: trypanosoma brucei dihydrofolate reductase (tbdhfr) in complex with2 wr99210
20 | d1df7a_ |
|  | 100.0 | 36 | Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases
21 | c2blcA_ |
| not modelled | 100.0 | 29 | PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase-thymidylate synthase; PDBTitle: sp21 double mutant p. vivax dihydrofolate reductase in2 complex with des-chloropyrimethamine
22 | d1vdra_ |
| not modelled | 100.0 | 33 | Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases
23 | c3clbA_ |
| not modelled | 100.0 | 37 | PDB header:oxidoreductase, transferase Chain: A: PDB Molecule:dhfr-ts; PDBTitle: structure of bifunctional tcdhfr-ts in complex with tmq
24 | d1seja1 |
| not modelled | 100.0 | 33 | Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases
25 | d1juva_ |
| not modelled | 100.0 | 22 | Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases
26 | d1d1ga_ |
| not modelled | 100.0 | 26 | Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases
27 | c3jtwB_ |
| not modelled | 99.9 | 19 | PDB header:oxidoreductase Chain: B: PDB Molecule:dihydrofolate reductase; PDBTitle: crystal structure of putative dihydrofolate reductase (yp_805003.1)2 from pediococcus pentosaceus atcc 25745 at 1.90 a resolution
28 | c2gd9A_ |
| not modelled | 99.8 | 17 | PDB header:oxidoreductase Chain: A: PDB Molecule:hypothetical protein yyap; PDBTitle: crystal structure of a putative dihydrofolate reductase (bsu40760,2 yyap) from bacillus subtilis at 2.30 a resolution
29 | c2xw7A_ |
| not modelled | 99.8 | 16 | PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: structure of mycobacterium smegmatis putative reductase ms0308
30 | c3ky8B_ |
| not modelled | 99.6 | 18 | PDB header:biosynthetic protein Chain: B: PDB Molecule:putative riboflavin biosynthesis protein; PDBTitle: crystal structure of putative riboflavin biosynthesis protein2 (yp_001092907.1) from shewanella sp. pv-4 at 2.12 a resolution
31 | d2hxva1 |
| not modelled | 99.5 | 20 | Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:RibD C-terminal domain-like
32 | c3kgyA_ |
| not modelled | 99.4 | 19 | PDB header:oxidoreductase Chain: A: PDB Molecule:bifunctional deaminase-reductase domain protein; PDBTitle: crystal structure of putative dihydrofolate reductase (yp_001636057.1)2 from chloroflexus aurantiacus j-10-fl at 1.50 a resolution
33 | d2azna1 |
| not modelled | 99.4 | 16 | Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:RibD C-terminal domain-like
34 | d2b3za1 |
| not modelled | 99.4 | 15 | Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:RibD C-terminal domain-like
35 | c2hxvA_ |
| not modelled | 99.3 | 20 | PDB header:biosynthetic protein Chain: A: PDB Molecule:diaminohydroxyphosphoribosylaminopyrimidine deaminase/ 5- PDBTitle: crystal structure of a diaminohydroxyphosphoribosylaminopyrimidine2 deaminase/ 5-amino-6-(5-phosphoribosylamino)uracil reductase (tm1828)3 from thermotoga maritima at 1.80 a resolution
36 | c2o7pA_ |
| not modelled | 99.2 | 15 | PDB header:hydrolase, oxidoreductase Chain: A: PDB Molecule:riboflavin biosynthesis protein ribd; PDBTitle: the crystal structure of ribd from escherichia coli in complex with2 the oxidised nadp+ cofactor in the active site of the reductase3 domain
37 | c2d5nB_ |
| not modelled | 99.2 | 16 | PDB header:hydrolase, oxidoreductase Chain: B: PDB Molecule:riboflavin biosynthesis protein ribd; PDBTitle: crystal structure of a bifunctional deaminase and reductase2 involved in riboflavin biosynthesis
38 | c2p4gA_ |
| not modelled | 98.8 | 17 | PDB header:oxidoreductase Chain: A: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of a pyrimidine reductase-like protein (dip1392)2 from corynebacterium diphtheriae nctc at 2.30 a resolution
39 | d1aoga2 |
| not modelled | 66.2 | 13 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
40 | d1q1ra2 |
| not modelled | 47.6 | 19 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
41 | d1gesa2 |
| not modelled | 38.5 | 21 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
42 | d1gera2 |
| not modelled | 33.9 | 18 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
43 | d3grsa2 |
| not modelled | 32.9 | 10 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
44 | d1onfa2 |
| not modelled | 28.4 | 17 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
45 | d1m6ia2 |
| not modelled | 27.4 | 27 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
46 | d1feca2 |
| not modelled | 22.3 | 17 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
47 | d1nhpa2 |
| not modelled | 21.2 | 27 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
48 | d1gv4a2 |
| not modelled | 20.3 | 33 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
49 | c3fq6A_ |
| not modelled | 20.1 | 17 | PDB header:transferase Chain: A: PDB Molecule:methyltransferase; PDBTitle: the crystal structure of a methyltransferase domain from bacteroides2 thetaiotaomicron vpi
50 | d1h6va2 |
| not modelled | 18.3 | 15 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
51 | c3ihtB_ |
| not modelled | 16.7 | 11 | PDB header:transferase Chain: B: PDB Molecule:s-adenosyl-l-methionine methyl transferase; PDBTitle: crystal structure of s-adenosyl-l-methionine methyl transferase2 (yp_165822.1) from silicibacter pomeroyi dss-3 at 1.80 a resolution
52 | d1rm6b2 |
| not modelled | 16.2 | 11 | Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CO dehydrogenase flavoprotein N-terminal domain-like
53 | d1udxa3 |
| not modelled | 15.8 | 18 | Fold:Obg GTP-binding protein C-terminal domain Superfamily:Obg GTP-binding protein C-terminal domain Family:Obg GTP-binding protein C-terminal domain
54 | c3q3vA_ |
| not modelled | 15.7 | 13 | PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of phosphoglycerate kinase from campylobacter2 jejuni.
55 | c1jb9A_ |
| not modelled | 15.1 | 16 | PDB header:oxidoreductase Chain: A: PDB Molecule:ferredoxin-nadp reductase; PDBTitle: crystal structure of the ferredoxin:nadp+ reductase from maize root at2 1.7 angstroms
56 | c1zmrA_ |
| not modelled | 14.3 | 18 | PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of the e. coli phosphoglycerate kinase
57 | d1d7ya2 |
| not modelled | 14.0 | 18 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
58 | d1vjda_ |
| not modelled | 13.9 | 17 | Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase
59 | d1hdia_ |
| not modelled | 13.5 | 20 | Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase
60 | d1fw8a_ |
| not modelled | 13.3 | 17 | Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase
61 | d1vdca2 |
| not modelled | 13.2 | 22 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
62 | c3cqyA_ |
| not modelled | 12.5 | 30 | PDB header:transferase Chain: A: PDB Molecule:anhydro-n-acetylmuramic acid kinase; PDBTitle: crystal structure of a functionally unknown protein (so_1313) from2 shewanella oneidensis mr-1
63 | d1ojta2 |
| not modelled | 11.8 | 18 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
64 | c1rm6E_ |
| not modelled | 11.7 | 11 | PDB header:oxidoreductase Chain: E: PDB Molecule:4-hydroxybenzoyl-coa reductase beta subunit; PDBTitle: structure of 4-hydroxybenzoyl-coa reductase from thauera2 aromatica
65 | d1qpga_ |
| not modelled | 11.5 | 21 | Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase
66 | d1ebda2 |
| not modelled | 11.3 | 20 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
67 | d2b4ya1 |
| not modelled | 11.1 | 20 | Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators
68 | d1lvla2 |
| not modelled | 11.1 | 30 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
69 | c3okfA_ |
| not modelled | 10.9 | 11 | PDB header:lyase Chain: A: PDB Molecule:3-dehydroquinate synthase; PDBTitle: 2.5 angstrom resolution crystal structure of 3-dehydroquinate synthase2 (arob) from vibrio cholerae
70 | d1jeoa_ |
| not modelled | 10.7 | 27 | Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain
71 | d1gg4a1 |
| not modelled | 10.5 | 21 | Fold:MurD-like peptide ligases, peptide-binding domain Superfamily:MurD-like peptide ligases, peptide-binding domain Family:MurCDEF C-terminal domain
72 | d1ltka_ |
| not modelled | 10.3 | 17 | Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase
73 | d1dxla2 |
| not modelled | 9.0 | 26 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
74 | d16pka_ |
| not modelled | 8.7 | 17 | Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase
75 | d1xhca2 |
| not modelled | 8.5 | 19 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
76 | d1phpa_ |
| not modelled | 8.5 | 26 | Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase
77 | c2jraB_ |
| not modelled | 8.5 | 28 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:protein rpa2121; PDBTitle: a novel domain-swapped solution nmr structure of protein rpa2121 from2 rhodopseudomonas palustris. northeast structural genomics target rpt6
78 | d1vpea_ |
| not modelled | 8.4 | 21 | Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase
79 | d2gs5a1 |
| not modelled | 8.1 | 12 | Fold:VC0467-like Superfamily:VC0467-like Family:VC0467-like
80 | c2hjhB_ |
| not modelled | 8.1 | 23 | PDB header:hydrolase Chain: B: PDB Molecule:nad-dependent histone deacetylase sir2; PDBTitle: crystal structure of the sir2 deacetylase
81 | c1xahA_ |
| not modelled | 8.0 | 9 | PDB header:lyase Chain: A: PDB Molecule:3-dehydroquinate synthase; PDBTitle: crystal structure of staphlyococcus aureus 3-dehydroquinate2 synthase (dhqs) in complex with zn2+ and nad+
82 | d1v6sa_ |
| not modelled | 7.8 | 19 | Fold:Phosphoglycerate kinase Superfamily:Phosphoglycerate kinase Family:Phosphoglycerate kinase
83 | d2i14a2 |
| not modelled | 7.7 | 20 | Fold:alpha/beta-Hammerhead Superfamily:Nicotinate/Quinolinate PRTase N-terminal domain-like Family:NadC N-terminal domain-like
84 | c2cunA_ |
| not modelled | 7.5 | 24 | PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of phosphoglycerate kinase from pyrococcus2 horikoshii ot3
85 | c3hl0B_ |
| not modelled | 7.3 | 20 | PDB header:oxidoreductase Chain: B: PDB Molecule:maleylacetate reductase; PDBTitle: crystal structure of maleylacetate reductase from agrobacterium2 tumefaciens
86 | c3ce9A_ |
| not modelled | 6.7 | 16 | PDB header:oxidoreductase Chain: A: PDB Molecule:glycerol dehydrogenase; PDBTitle: crystal structure of glycerol dehydrogenase (np_348253.1) from2 clostridium acetobutylicum at 2.37 a resolution
87 | c3f3mA_ |
| not modelled | 6.6 | 25 | PDB header:transferase Chain: A: PDB Molecule:phosphopantetheine adenylyltransferase; PDBTitle: six crystal structures of two phosphopantetheine2 adenylyltransferases reveal an alternative ligand binding3 mode and an associated structural change
88 | d1krha2 |
| not modelled | 6.5 | 13 | Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:Aromatic dioxygenase reductase-like
89 | c1kyqC_ |
| not modelled | 6.5 | 38 | PDB header:oxidoreductase, lyase Chain: C: PDB Molecule:siroheme biosynthesis protein met8; PDBTitle: met8p: a bifunctional nad-dependent dehydrogenase and2 ferrochelatase involved in siroheme synthesis.
90 | d1kyqa1 |
| not modelled | 6.4 | 38 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Siroheme synthase N-terminal domain-like
91 | d2h3ka1 |
| not modelled | 6.3 | 17 | Fold:Immunoglobulin-like beta-sandwich Superfamily:NEAT domain-like Family:NEAT domain
92 | d1fcda1 |
| not modelled | 6.3 | 26 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
93 | d1jb9a2 |
| not modelled | 6.3 | 16 | Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:Reductases
94 | c3dfzB_ |
| not modelled | 6.3 | 18 | PDB header:oxidoreductase Chain: B: PDB Molecule:precorrin-2 dehydrogenase; PDBTitle: sirc, precorrin-2 dehydrogenase
95 | d1fl2a2 |
| not modelled | 6.1 | 29 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains
96 | c3hrdC_ |
| not modelled | 6.0 | 18 | PDB header:oxidoreductase Chain: C: PDB Molecule:nicotinate dehydrogenase fad-subunit; PDBTitle: crystal structure of nicotinate dehydrogenase
97 | d1ddga2 |
| not modelled | 6.0 | 22 | Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:NADPH-cytochrome p450 reductase-like
98 | d1up7a1 |
| not modelled | 5.8 | 43 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:LDH N-terminal domain-like
99 | d1v59a2 |
| not modelled | 5.8 | 24 | Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain Family:FAD/NAD-linked reductases, N-terminal and central domains

Binding site prediction |

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0