>ss_pred
CEEEEEEEECCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHCCCCCCCCEEEEEECCCCCCCCCEEECCHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCEEEEEEECCCCCCCEECCCCCHHHEEEEEEEECCCCCCCCCCEEEEEEEEC
>ss_conf
979999972698786557778677899999998605986999110075478643796699990236789881998599999985258983999845899999987469899989758768735676669566389875305766657862699999859
>batch____
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
>UniRef50_Q5R038(3-164:166) Dihydrofolate reductase n=3 Tax=Alteromonadales RepID=Q5R038_IDILO   E=5e-45 s/c=1.12 id=54% cov=99%
-ISLVVAMADNRVIGKDNKMPWHLPDELQYFKKITLGKPIVMGRRTFESIGRPLPGRKNIVLSRRTdrseNQDSQVVWVSGVQQAIAAAGPVEELMIIGGGKIYEKFLPLADRLYVTKIELNVEGDTYFPDYhQVADWQEIERQNFAADERNSHNFSTLIFDR-
>UniRef50_P43791(3-160:160) Dihydrofolate reductase n=19 Tax=Gammaproteobacteria RepID=DYR_HAEIN  E=4e-43 s/c=1.11 id=53% cov=100%
-FSLIVATTLNNVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIVLSRQLFEHEGVIWKDSFESAVNFVRDFDEIMLIGGGELFKQYLPKADKLYLTQIQTELDGDTFFPQLNWEEWEIEFDEYRKADEQNRYDCRFLILTRK
>UniRef50_P12833(2-161:162) Dihydrofolate reductase type 3 n=26 Tax=Proteobacteria RepID=DYR3_SALTY  E=3e-40 s/c=1.04 id=51% cov=101%
LISLIAALAHNNLIGKDNLIPWHLPADLRHFKAVTLGKPVVMGRRTFESIGRPLPGRRNVVVSRNPQwQAEGVEVAPSLDAALALLTDCEEAMIIGGGQLYAEALPRADRLYLTYIDAQLNGDTHFPDYLSLGWQELERSTHPADDKNSYACEFVTLSRQ
>UniRef50_Q3JEI1(2-160:165) Dihydrofolate reductase n=3 Tax=Gammaproteobacteria RepID=Q3JEI1_NITOC  E=3e-35 s/c=0.94 id=45% cov=100%
IISFIVAMDENHLIGANRRLPWHLPADLKYFRRMTMGKPMLMGRSTHEAIGRPLPGRHNIVVTHNPDYKaPGCTVVHTVEAGLQAAGEAEEVTVIGGASLYEQLLPQARRIYLTLVRGHFQGDTWFPAFDPGTWVEVWREDYDPDPQNPYPYSFIRLER-
>UniRef50_Q89AV2(3-162:164) Dihydrofolate reductase n=5 Tax=Buchnera aphidicola RepID=DYR_BUCBP   E=5e-35 s/c=0.93 id=44% cov=99%
-ISIIVAMSQNLVIGQKNSIPWNIPKDLSWFKKHTIKKSIIMGRKTWESIGRVLPMRQNIVLTRQKNIKNtNVLFVNSISKAIQSALYKNEIMIIGGSNLYNQMLTSANKLYITHIEKYILGDTYFPTYDHLPWkiIFKKKIIEHEKTKNSFYVTFKILKK-
>UniRef50_A1U3D7(4-167:171) Dihydrofolate reductase n=6 Tax=Gammaproteobacteria RepID=A1U3D7_MARAV  E=2e-33 s/c=0.87 id=46% cov=97%
--ALIVAMARNRVIGRNNKLPWYLPGDLRYFKQATMGKPIIMGRKTWDSIGRPLPGRMNVVISRNPewqapaGTVAAASlneaLVKAEAQANLEGGD--EVMIIGGGQIYAEALPMVDRIYITQVHAEVDGDAFFPEVNWDEWEEIGREDFSASDNNPYDYSFVVYQR-
>UniRef50_C6CYL9(3-161:163) Dihydrofolate reductase n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CYL9_PAESJ  E=2e-31 s/c=0.86 id=44% cov=99%
-ITMIAAMDRGRTIGIGNKLPWRLPAEMAYFTRHTTGKAVVMGRKTFESLPKPLKDRTNVVITRQPEyAKEGCEVVHSVQEAIDRYGE-GELMVIGGADIYAQFLPFADKIRLTEVDTNIEgGDAFFPTFNEGEWERVDAEKVESDERNAFSFTFQTFARR
>UniRef50_D2QJY0(3-162:163) Dihydrofolate reductase n=2 Tax=Bacteria RepID=D2QJY0_9SPHI   E=2e-31 s/c=0.85 id=45% cov=99%
-ISLIAAVAQNGVIGRENDLPWHLPDDFAFFKRKTSHHPIIMGRKSLESLGKPLPNRTNIVLTRNAEfSAAGVTIVHTLDDAIAEAKAInqTEIFVIGGAEIYKMALPIATTLYLTEIHQDYDGDAYFPEFDKNEWQEVSRRPHPADERHAVSFDFVEYEK-
>UniRef50_Q2W7P5(17-174:175) Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q2W7P5_MAGSA   E=2e-29 s/c=0.82 id=47% cov=97%
-VALIVAVAANGVIGKDNALPWHIPEDLKWFKENTLGKPVIMGRKTWESIGRPLPKRPNIVVTRQTGwRAEGAHTAHSLDealaLAARLAPEAAELMVIGGNSLFAEALPGARRLYLTEIARAYEGDTMFPAFERGLWHEVSRRRNEGDP----AFDFVILDR-
>UniRef50_A7HVX5(3-167:169) Dihydrofolate reductase n=13 Tax=Proteobacteria RepID=A7HVX5_PARL1   E=3e-29 s/c=0.78 id=42% cov=99%
-VSYVVAIADNGVIGRDNSLPWRLSGDMAFFKRITMGKPVIMGRKTWESLPRkPLPGRPNIVVTRDAqyeaeGAEIAASAVEALRRGreLASASGADEVMVIGGAQLYAEMFDDATRLYITEVHAAPEGDVSFPAFDAAHWREVSRERHKAGEKDSADYSFVVLER-
>UniRef50_A6UB22(14-178:187) Dihydrofolate reductase n=18 Tax=Alphaproteobacteria RepID=A6UB22_SINMW  E=6e-29 s/c=0.78 id=43% cov=100%
-IVIVVAVALNGVIGREGDLPWRLPTDLKRFKAQTIGKPVIMGRKTWAAIGRPLPGRPNIVVTRNrafeaPGAEvaPSLEAALAVARERAAAIGADEICVIGGGEIYRQSIGMADVLHVTEVQAEVDGDTRFPEIDPAVFEKVLEEDLQSGEKDSHAMHFVTWRRR
>UniRef50_Q5X875(3-160:163) Dihydrofolate reductase FolA n=6 Tax=Legionella RepID=Q5X875_LEGPA   E=3e-28 s/c=0.80 id=40% cov=100%
LISLIAAIDETGGLGINNQLLCYLPADLQHFKSITMGKPIIMGRKTYESIGKPLPGRLNIVISQSIQSIPGVVVVDSLGQAIKETADASEVMIIGGAKIYSQAISIANRLYITRIHHQFMADVFFPKINELVWSCRSKEYRQHDNKNQYDMTFCIYER-
>UniRef50_D0XKH5(6-174:175) Dihydrofolate reductase n=1 Tax=Brevundimonas subvibrioides ATCC 15264 RepID=D0XKH5_9CAUL  E=1e-27 s/c=0.73 id=43% cov=99%
-IALVVARARNGVIGRDGDLPWKLRSDLQRFKQITLGKPCIMGRSTWESLPlRPLPGRLNLVLSRDLSYEERgkakgavvcSNLADAIDMARETAEDdgIDEICVIGGTALFEAALPRAKRLYITEVEAEPEGDALFPAFDESLFAETLNERHDAGEKDDHPFVFRILDR-
>UniRef50_B6INW3(24-189:190) Dihydrofolate reductase n=4 Tax=Alphaproteobacteria RepID=B6INW3_RHOCS  E=2e-27 s/c=0.74 id=43% cov=100%
-LVLVAAVARNGVIGRGNTLPWRLPGDLRFFKRTTMGKPVVMGRRTWESIGaKPLPGRCNIVLTRDTGFAPEGAivchgFLGAIAEArsVAARTGAPEVCVIGGESLFAEALRMADRLYLTEVLAEPAGDVLFPPFDRGAWMQTELERADAAGPDSPAYRILRLDRK
>UniRef50_C6X2F4(1-161:167) Dihydrofolate reductase n=20 Tax=Bacteroidetes RepID=C6X2F4_FLAB3   E=9e-27 s/c=0.75 id=38% cov=101%
MITIVVAMGLKNEIGADNQLLWHLPQDLKHFKEITTGHPIIMGRKTYESIGRPLPNRTNIVVSRKKDwFAEGVLIVGSLKEALKFAKKIDEnVFVIGGGNIYEQTIDLADKLEVTLVKAEINADIFFPKIDLKIWEKTSETCIDKDEKHAYDFCFQTFVKK
>UniRef50_Q7VQK5(2-167:168) Dihydrofolate reductase type I n=1 Tax=Candidatus Blochmannia floridanus RepID=Q7VQK5_BLOFL  E=1e-26 s/c=0.72 id=42% cov=97%
IISLIAAFTINYVIGRKNIIPWYFSWDMMWFKYHTMYKPVIMGRKTFESMNsKPLPYRLNIVLSKH-----HILYNNKIHNIFIACNPIQalsvvqkndEVMIIGGGLVYNAFMSQCTRMYLTKIDVVYNyGDSWFPSYNPNEWCVVYNTNKKCVINTGYTYnlNFQILDR-
>UniRef50_A0PY39(1-163:170) Dihydrofolate reductase n=3 Tax=Clostridium RepID=A0PY39_CLONN   E=1e-25 s/c=0.72 id=38% cov=100%
MLSIVVAIGKNNVIGKDHSLPWHLPNDLKYFKKVTLteSKTMIMGRKTFQSLKALLPGRKHIILTKNKNfnmKDSNVEIINKIDMLKPIINDKKEYFVIGGGEIFSLLLPYTEKIYMTKIHHNFIGDTFFPNINRYDWNTTKEIQGITDEKNVYNHTFLILNR-
>UniRef50_C8X9J8(8-159:292) Dihydrofolate reductase n=1 Tax=Nakamurella multipartita DSM 44233 RepID=C8X9J8_NAKMY  E=2e-25 s/c=0.77 id=42% cov=95%
-VVLVAAVARNGVIGAAGTMPWHIPADLKRFKRLTMGHPMVMGRKTFESMGL-LPGRRSIVITRDPHwRAPGAEVADSLDRAIALGAQTdPVVMVVGGGEIYAQALPRADRLEITHLDLSAPGDTVFPAIDPALWAVT-------DREEADGYAFVTYRRR
>UniRef50_Q0C500(7-171:176) Dihydrofolate reductase n=4 Tax=Alphaproteobacteria RepID=Q0C500_HYPNA  E=4e-25 s/c=0.70 id=45% cov=99%
-LCLIVAQARNRIIGAAGALPWRLKDDMAFFKATTMGAPVIMGRKTWESFpKRPLPGRENIVLTRDWDYDAAEARVYSsfpaamnAARAIAAREGKDEAFVIGGAEIYALALPFADRIYLTEVDAEIEGDTLFPELDLRQWRSDEIATHPAGEGNDHAFIIRRLDR-
>UniRef50_D2QWB5(11-168:171) Dihydrofolate reductase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2QWB5_9PLAN  E=1e-24 s/c=0.72 id=38% cov=99%
-LSLIVAMTREGLIGRDRDLPWKISADLKRFRSLTMGHTIIMGRTTWDSLGRALPGRTSIVLTRKADlvLPEGVLRAGSLDEAIALAAGDSEPFIIGGGEIYRQAMDRVQQLYVTWVEANIEGDTWFPAWDPSKFRLLEETSHPAEG-TTPAFTFTRYER-
>UniRef50_Q04F50(1-164:170) Dihydrofolate reductase n=2 Tax=Oenococcus oeni RepID=Q04F50_OENOB   E=1e-24 s/c=0.70 id=40% cov=101%
MITSIWAQSKNNVIGRNNHLPWSLPDDLKFFRQETKNKAVVMGRKTYESFGsKALPKRLNIILTSNMDFKSNDPEVKIVHSPIEAVNTAKEqhlpLYVIGGASVYESFMNMADRLLITLVDANIKGDTFAPNFSEKSFSLVSQCHHAQDKKHAYSFDFLTYERK
>UniRef50_B0VHY5(1-138:141) Dihydrofolate reductase n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VHY5_9BACT  E=2e-23 s/c=0.80 id=41% cov=87%
-------------------MPWKITEDLKRFKAITMGHPVIMGKNTWNSIGKPLPGRQNIVLSKDRNFQPQGAIVAhSLEEALKMV-EGQEAYIIGGASVFKQFLPLADKMLITLIHSEFEGDTYFPYFSEEDW--ILQESSSLLSSSGYELCLQIYIRK
>UniRef50_A7IF75(11-153:178) Dihydrofolate reductase n=3 Tax=Rhizobiales RepID=A7IF75_XANP2   E=2e-23 s/c=0.77 id=42% cov=85%
-LALVVAVSQNGVIGTDGGLPWRLPSDLKRFRALTWGKPLLMGRRTYESIGRPLPGRTSVVVSTDPAFTVPEGVLKGasledglrlADEAADAMG-ADEIMVIGGARLFHDTLPLARTLHLTQVHAAPDGDVFFPAFDEAQWREI-----------------------
>UniRef50_Q0AN20(8-172:173) Dihydrofolate reductase n=4 Tax=Alphaproteobacteria RepID=Q0AN20_MARMM  E=7e-23 s/c=0.65 id=39% cov=99%
-LVLVVARGMNGVIGVDGDLPWRLSSDLRNFKAITSGKPIIMGRKTWESLpRRPLPGRLNIVVTRQDGYVAEGGHVagdlgEAMDAAFmrADADGVDEVCVIGGAQIYAATLERADRLYLTEVEAAPEGETCLPEIDEALWRETRRELYPAGPGDDHAFMLRVLDR-
>UniRef50_B5EIA1(2-155:306) Dihydrofolate reductase region n=5 Tax=Geobacter RepID=B5EIA1_GEOBB   E=2e-22 s/c=0.69 id=40% cov=97%
IISTIAALSDNRVIGADGGLPWDIPSDLTRFRSITMGHTVIMGRKTYESIGHPLLGRRNIVLTRKGSQIEGCEIARNVPAAIAAAEGEEEVFICGGGEVFQEALPLCQRLYLTVVHGNYRGDAFLPELPEGFVELHREEFPDTTPPSS----FVVLEK-
>UniRef50_D0J8Z9(3-172:173) Dihydrofolate reductase n=2 Tax=Blattabacterium RepID=D0J8Z9_BLASP   E=3e-22 s/c=0.62 id=38% cov=99%
-IILISAVSSNGVIGKNNQLMWHLPNDLKRFKNMTFGETVLMGRKTFESIGKILPGRRNIILTkknkihffSSTNTNNK-TNPRGTFEVYSSLKQIydlnyKKIFVIGGEKIYTSTIDKAHIIELTVIHKKFYGDAKFPKIPLSKWKKTYEFFHEKDKHHLYNYSFIRYERK
>UniRef50_A6GQA5(3-163:188) Dihydrofolate reductase n=1 Tax=Limnobacter sp. MED105 RepID=A6GQA5_9BURK  E=3e-22 s/c=0.66 id=46% cov=86%
-VSIVAAVAENGIIGINNSLPWHLPEDLAFFKQTTLGCPVLMGRKTYESINRPLPGRLNVVLSSNsdwkpaPGKDGTprsvITHPAALPEGsatqIATATNLPdalnwlssfeQVFLIGGSNLYEQALAQGlvDELILTEIHQSFEGDASFPQWDRQQFREV-----------------------
>UniRef50_C5NYS7(1-160:163) Dihydrofolate reductase n=1 Tax=Gemella haemolysans ATCC 10379 RepID=C5NYS7_9BACL  E=3e-22 s/c=0.66 id=32% cov=101%
MLSLIVAYDKNKSIGQENTIPWRLKNDMLRVKELTTNQTIIMGRKTLDSIGRALPNRINRVLTRDKDSLSHYSNIEvYTDDSILDNIETEKAYIFGGGMIYNKYFDKCDEMFITEVNTIVEADTKFPEFDENEWELISREEFFKDENNEFDFVFIHFKRK
>UniRef50_C2MBL2(3-165:173) Dihydrofolate reductase n=1 Tax=Porphyromonas uenonis 60-3 RepID=C2MBL2_9PORP  E=5e-22 s/c=0.64 id=40% cov=99%
-IWIIVATARDRAIGRDGTMPWRLKDDLRRLKATTTGHAVIMGRHTWDSIGaRPLPNRYNIVVSrTLPEGDAETHYVAStLEQALQHCqqAGYDRVYIMGGGVLYKSGLPYATHLNLTMVDTVVpDADTHFPEINLSEWSKLEEAHYPADERNDYPVTQTLYKR-
>UniRef50_Q3A0W8(16-160:167) Dihydrofolate reductase n=1 Tax=Pelobacter carbinolicus DSM 2380 RepID=Q3A0W8_PELCD  E=5e-22 s/c=0.72 id=42% cov=82%
-MTIVVAMTAERIIGRRGQLPWSIPEDLALFRRLTYGHTLVMGRRTFESIGRPLPGRFNIVVSRSmpPVEGLRVCrhFAEALQVADQGNGD---IFFIGGCEIYRQALIVAGKLSVSWIRKNYPGDCRFPEYRSDDW--------------------------
>UniRef50_C9RIZ1(2-162:163) Dihydrofolate reductase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RIZ1_FIBSS  E=2e-21 s/c=0.64 id=39% cov=99%
LISAIVAVSENNVIGRDGHLPWHLSADLKRFKAITTGHAIILGRKNYDDIGRPLPNRTNYVLTRNkdfqaPGCIVCSSLGEAI-EAARAAGET-ECFIIGGAAVYREAMPLVEKLYLTRVLSHVEGDVFFPEWN-DKFQKESAESFPADEKNDFPTTFEIWVRK
>UniRef50_D1BNV5(1-156:164) Dihydrofolate reductase region n=4 Tax=Veillonellaceae RepID=D1BNV5_VEIPT  E=1e-20 s/c=0.64 id=38% cov=96%
MLALIVAVAHNRVIGKDNTLIWHLPNDLKFFKEKTTGHVIIMGRKTFESLPFLLPNREHWVITRDKGFDapEGVKIFHNPEAAAEAARALDAAYVIGGAQVYEAFLPYVDTMYITEVDHEFDGDAFFPEFSEDAFtiESVVDGIVDEKNQYPHRFV-------
>UniRef50_Q54801(16-166:168) Dihydrofolate reductase n=65 Tax=Streptococcus RepID=DYR_STRPN   E=2e-20 s/c=0.66 id=36% cov=92%
------------VIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRlLPKRETLILTRNP--EEKIDGVATFQDVQSVLdwyqAQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPeELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRK
>UniRef50_C7N8V9(1-162:173) Dihydrofolate reductase region n=5 Tax=Fusobacteriaceae RepID=C7N8V9_LEPBD  E=6e-20 s/c=0.61 id=37% cov=89%
MFSLIVAVGENNEIGKNNQLLWHIPEDLKNFKKITMGKTVIMGKNTYKSIGKPLPNRKNIVLSRNPLeieekiKEDRKKY-ENENTKLELCDNLQkiidkyknseeEIFIIGGGEIYKKAfeMKIVKRIYMSHVNfSDKNADTYFPKIDLKKWVVITKENYD-----------------
>UniRef50_A1SJ32(8-151:160) Dihydrofolate reductase n=1 Tax=Nocardioides sp. JS614 RepID=A1SJ32_NOCSJ  E=6e-20 s/c=0.68 id=39% cov=89%
-VVLVAAVARNGVIGDGPDIPWQLPGEQRLFKGLTWGHILVMGRATYDSIGRPLPGRTTIVLTRSPDWSAEGVHVAHDLPAALALADTleGEVMVAGGGQVYAAALPVADEQVLSEVDLEPQGDAFYPEFDRSEWRETAREQHD-----------------
>UniRef50_Q59408(8-163:165) Dihydrofolate reductase type A13 n=57 Tax=Bacteria RepID=DYR13_ECOLX  E=6e-20 s/c=0.63 id=38% cov=96%
-IYLVAAMGANRVIGNGPDIPWKIPGEQKIFRRLTESKVVVMGRKTFESIGKPLPNRHTVVLSRQAGYSapgcAVVSTLSHVSPSTAEHGK--ELYVARGAEVYALALPHANGVFLSEVHQTFEGDAFFPVLNAAEFEVVSSE----TIQGTITYTHSVYARR
>UniRef50_A1TM51(3-165:165) Dihydrofolate reductase n=4 Tax=cellular organisms RepID=A1TM51_ACIAC  E=1e-19 s/c=0.60 id=38% cov=99%
-LRLIYARAANGGIGLHNAMPWHLPEDLAHFKQLTLGATVVMGRKTWDSLParfRPLPGRTNIVVTRQAGwHADGALSASSLEQAVELArphGDT--VWVMGGAQIYAQALPMADGVEVTEIHRDFEADAFAPVLGPEWEETARTPVQTSAGSAALPFSFVSYRRR
>UniRef50_A1WYQ0(4-160:164) Dihydrofolate reductase n=1 Tax=Halorhodospira halophila SL1 RepID=A1WYQ0_HALHL  E=1e-19 s/c=0.62 id=40% cov=97%
-IVLVAIVGRNGVIGADGDQPWHFRCDLQRFKALTRGHPVIMGRRTLAAIGRPLPQRTNIVLTRDPGFHADGVEVATDPEAALARAAESaggeRVMILGGGDVYRLFLPRAHRLALTEVDDAPPGDTTFPAIGP-EWQETAREEAEEDG---YRLTFRTLLR-
>UniRef50_Q1WU16(1-167:167) Dihydrofolate reductase n=5 Tax=Lactobacillus RepID=Q1WU16_LACS1   E=6e-19 s/c=0.57 id=35% cov=101%
MISFVWAEDQKHQIGYKGHLPWRLPADLAHFKEVTMGHPMVMGKKTFDSFPGLLPRRQHIVLTHDTNLEEKykdnpqVEIMNSIDELTSWLDEnqFQEVSVIGGAMLFNLLLNKVDKLYKTEILSEFNGDTVMPTINYDEFKLVSKKIGKVDEKNKYPYVFLEYERK
>UniRef50_B9YFM0(3-165:166) Dihydrofolate reductase region n=3 Tax=Nostocaceae RepID=B9YFM0_ANAAZ  E=1e-18 s/c=0.58 id=38% cov=92%
LISLIAAISENRILAdskkehIRVGIPWDIPSDLQHFQKKTWRHPVILGRKSYAAFNHPLPNRTNIILTRShdykaPGClvfyslSEAVTWAK--------MSEKEEIFIAGGGEIFAEAIKFANKLYLTIVEGNFEGDVYFPEF--TNFGTVTKEEH--SQENDFQFKFVEIER-
>UniRef50_Q3F0Y0(1-171:172) Dihydrofolate reductase n=2 Tax=Bacillus thuringiensis RepID=Q3F0Y0_BACTI  E=2e-18 s/c=0.55 id=37% cov=100%
MISLIVAADENNAIGFENKLLCRLKDDMKHFIKKTKGKPIIMGYKTFASLGhKPLKDRFNIVLTRSPmaltldhlhlvGENLVFESLEYIQFMIEQSKD-KEIVVIGGQQTYELFLPMASRVYLTRIHHSFpEADSYFPMLDSSEWSSKLDAKHAESEDNDHPFSIYTFERK
>UniRef50_D1PWR8(3-144:163) Dihydrofolate reductase n=1 Tax=Prevotella bergensis DSM 17361 RepID=D1PWR8_9BACT  E=3e-18 s/c=0.65 id=36% cov=89%
-ISIIVAMARNRAIGFRNHLLYHLPDDMKHFKALTTGHTIIMGRHTFDSLpNGALLHRRNIVVSRSRTHIVGCEVFGSLEQAIASCRGEQEVFIIGGESIYRQALAVAHRIYLTLVdDTPTQFDTVFPEIDMSHWQETKKEKH------------------
>UniRef50_C0EGY7(1-159:319) Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum DSM 5476 RepID=C0EGY7_9CLOT  E=4e-18 s/c=0.58 id=38% cov=95%
MIKMKCIVAVDQAwgIGCENGLLYSIPEDMAFFRKTTLNKAVVMGRHTLESLpkSRPLKNRLNIVMSRdrslQIGGAITCCSLQDLGVALSIC-DSDDVYVMGGYAVYSLLLDFCGQALITKIQGQREADRFFPNIDRDnNW--TLSEQSDVRSHNGLCYSF------
>UniRef50_C7X688(4-164:165) Dihydrofolate reductase n=7 Tax=Bacteroidales RepID=C7X688_9PORP   E=5e-18 s/c=0.57 id=36% cov=100%
-ISIIAAIADKSAIGKNQQLLCHMPSDMKRFKELTTGHAVIMGRKTFESLPvAPLPNRKNVVLTTMPEAGFVNCFaCESMGAALDLCEKEDEIFIIGGALVYRQALRIADKMYITRIHHEFpDATSFFPVVNWDLWEETEREEYPADEKNPYPYTYITYVRK
>UniRef50_B6BUF2(1-127:148) Dihydrofolate reductase n=1 Tax=beta proteobacterium KB13 RepID=B6BUF2_9PROT  E=8e-18 s/c=0.72 id=34% cov=81%
-------MSENNVIGIDNSLPWHLSGDLKRFKAITTGHQIVMGRKTYESIGKPLPNRVNFVLTRN--SDLKIDGVHVISSLNDISDSDKKTFIIGGGEIYSQLIDSCDELLVTKIHREIHGDAFFPMIDASVWSLV-----------------------
>UniRef50_C5CC92(11-185:186) Dihydrofolate reductase n=3 Tax=Actinobacteria (class) RepID=C5CC92_MICLC  E=8e-18 s/c=0.52 id=42% cov=96%
VIAMIWAQTPGRVIGRDGTMPWHVPEDLAHFRAHTHGHPVIMGRRTWESFParfRPLPGRTNIVVSRT------LTATEQAGAQLRAAGAvvVPDfgaalaaaaeadgcdtVWVIGGATLYDQALDVASRAEVTVIDADVDGDTHAPPLDARWRRTAVDPAPDAwlDSASGPRHRFERWER-
>UniRef50_P11731(3-156:157) Dihydrofolate reductase type 5 n=27 Tax=Bacteria RepID=DYR5_ECOLX   E=2e-17 s/c=0.59 id=36% cov=96%
-VSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAVVTRSAWTadNDNVIVFPSIEEAMYGLAELTDhVIVSGGGEIYRETLPMASTLHISTIDIEPEGDVFFPNI-PNTFEVVFEQHFSSNI----NYCYQIWQK-
>UniRef50_C7R3F1(11-146:191) Dihydrofolate reductase n=1 Tax=Jonesia denitrificans DSM 20603 RepID=C7R3F1_JONDD  E=3e-16 s/c=0.63 id=43% cov=81%
-LSLIWAQSLNGVIGRSGTIPWHEPTDLAHFQKTTRGGVVIMGRHTWESLPvTPLPQRVNIVLTSdrdyrAPGARVVTTPQQALDLAhwYTQVGH-QAIWVIGGRQVYDTFMDYATQLIVTTVGTVIEGDTEAPRIPP-----------------------------
>UniRef50_C5BYZ5(1-167:169) Dihydrofolate reductase n=1 Tax=Beutenbergia cavernae DSM 12333 RepID=C5BYZ5_BEUC1  E=3e-16 s/c=0.52 id=37% cov=89%
MIGMIWAQAHDGVIGARGTVPWHVPEDFAHFKATTRGHAVVMGRATWDSLPdryRPMPERRNVVVTRQVDwSADGAERAGSIPDALERCAAEPETWIMGGAQIYAEAMPYADTLVVTQLDlaLDVEGApdvVHAPPIGPewriatDTWDGTWQTS-------------------
>UniRef50_C7H0N2(3-161:162) Dihydrofolate reductase n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H0N2_9FIRM  E=5e-16 s/c=0.54 id=36% cov=92%
------------CIGKDGGLLVHLSKDLKYFKEKTIGKTLIVGRKTLESFpgGKPLPGRKTIVLTRNTSYKAEGAYVcHSKQEVLEKVKDLhpADVFVAGGGAIYKQFLNDVDKGFVTKICNEYSGDTFFPNLDEDEDFALESE-GETIEENGVKFKFCIYNR-
>UniRef50_Q14P23(1-141:160) Putative dihydrofolate reductase oxidoreductase protein n=1 Tax=Spiroplasma citri RepID=Q14P23_SPICI  E=8e-16 s/c=0.60 id=32% cov=86%
MIKLLWAMDENNLIGQNDQLPWHLREELQHFKETTLGQTILFGRLTYEGIGWPLPKRKTLVLTRHLDYQIKHPDVEVVTDLTAIInfyhqNPTEDIYICGGKKIYEATLPYADELIISLIKGKYQGDTYFPSFDLNQFTLI-----------------------
>UniRef50_A4GI75(2-167:168) Dihydrofolate reductase n=1 Tax=uncultured marine bacterium HF10_29C11 RepID=A4GI75_9BACT  E=2e-15 s/c=0.50 id=36% cov=98%
MLKMILAMDLDGCIGKENGLPWRLQSDMLRFKRLTIgqgNSAVLMGRTTWETIperFRPLVDRINIVVTRNRNyalSDAHVTY--SIENGIehASNNNCDECWIIGGADVYEQCRDLVDEIHLTSVETSNSGDIKVGMF-GDEWNREIIESTPESSDNEHPTTYMILRK-
>UniRef50_B7VPW7(29-182:183) Dihydrofolate reductase type I (Trimethoprim resistance) n=2 Tax=Vibrio splendidus RepID=B7VPW7_VIBSL  E=2e-15 s/c=0.54 id=33% cov=96%
-LSLMAAVAENGVIGSGLDIPWIVKGEQLLFKAMTFNQWLLLGRKTFESMGK-LPNRKYAVISRSPSTsnDPDILYFKSVEDALGYLETVTEhAFVSGGGQIYKSLITQVDTIHISKIHKHISGDIFFPEL-PRDLTLVFEQRFSSNID----YTYQIWQK-
>UniRef50_C0VZ67(3-152:170) Possible dihydrofolate reductase n=3 Tax=Actinomycetaceae RepID=C0VZ67_9ACTO  E=2e-14 s/c=0.54 id=36% cov=91%
VVKMIWAQDAEGKLGSGSEMLWHVPADFRHFKQSTVGFPLIMGRKSWDALGRfaPLPQRRNIVVTRNRDFIPEGGEVAfSIEEAISlASADSELVWIAGGAHIYEQAMPFADELVVTYLDLNVSTAgpvVYAPQIDPAVWEVVKAE-SDAD---------------
>UniRef50_B3RI81(1-173:174) Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RI81_TRIAD  E=2e-14 s/c=0.47 id=40% cov=88%
-------MTRDRGIGYKNDLPWKLRNEYKYFARLTTStkdsakkNAVLMGRNTWVSIpekNRPLRNRINIVISSQLRAEE-------VPEGVHVVASIPEVIelvqspllkdivetvwIVGGAPVYKGFMshPQCDRIYLTKLDANYECDVFFPEMSDD-----FKEISDPDVsqevqeENGLKYTFHVYQR-
>UniRef50_Q6A328(6-164:169) Dihydrofolate reductase n=1 Tax=Pasteurella multocida RepID=Q6A328_PASMU  E=9e-14 s/c=0.49 id=34% cov=96%
--SLIVAIGKHREMGADNDLLWHLPRDMQFFKETTTGHAVVMGRKSWESIpqkYRPLPNRLNFVLTRDKNySAEGATVIYDLKEVAQHLeGKNLTCFIIGGAQIYQLALETGllNEMYVTQVHNTFeEADTFFPFVNWGEWEE--EDILEQDKDEKHLYSFNI----
>UniRef50_A7SCT0(8-161:187) Predicted protein n=2 Tax=Nematostella vectensis RepID=A7SCT0_NEMVE   E=1e-12 s/c=0.48 id=36% cov=84%
-FSCIVAMDLKRGIGKNNDLPWKIKGDMKFFTEKTsevktegKQNAVIMGRKVWESIpekFRPLKGRLNIVLSrtlSEPPQGAQL--CRSFEQALTILSTDPytkkieNVFVCGGSALYKDAMAHSacTRIYITYIDQEFDCDVFFPEFDQNTYHLV-----------------------
>UniRef50_Q5V3R2(9-168:185) Dihydrofolate reductase 1 n=1 Tax=Haloarcula marismortui RepID=DYR1_HALMA  E=1e-12 s/c=0.46 id=38% cov=83%
-LVLVVAADENNVIGLDGGVPWHYPEDVRQYKNRIAGHPIILGRRTFESM-KPIPDCYTVVLTS----DDR----RSADSETVEYATTPQIaveaaaragasgafagdsagadssppvtYVIGGEAVYDLFLPFAGRVFLSRIHEHNEGDRYFPDLGA-EWTELSREPHD-----------------
>UniRef50_B9DU71(5-165:165) Dihydrofolate reductase n=13 Tax=Streptococcus RepID=B9DU71_STRU0   E=2e-12 s/c=0.45 id=34% cov=97%
---IIAIWAEDEngVIGANGTLPWYLPKELQHFKNTTLNHAILMGRVTFEGMKRRlLPNRQTLVLTSDESYHvDGALTMTSLEKTLEwYHAQENNLYVIGGQKVLQTFDGHFNKIIKTVVHHQFDGDTYRPelDLSPFVEEDCF--FYERDDQNPYDFTVHILVRK
>UniRef50_C4QMV9(3-175:186) Dihydrofolate reductase n=1 Tax=Schistosoma mansoni RepID=C4QMV9_SCHMA  E=3e-12 s/c=0.42 id=35% cov=96%
-LNVVVAVSENWGIGKGGGLPWKIKKDMEFFKTVTtkahpgLKNAVVMGRVTWESIpesFKPLKDRINIVVSSTLShAPSFVQVVPSLNAAIDLLYNeefssiVDEVFIIGGYRLYKEALKQSiypVRIYCTHILSEVDCDTYFPKVDWDKLKKVDLPDIPADTFTENGFTF------
>UniRef50_C3Z0P2(6-183:185) Putative uncharacterized protein n=2 Tax=Deuterostomia RepID=C3Z0P2_BRAFL  E=5e-12 s/c=0.41 id=35% cov=98%
-LSLVVAACNNMGIGVDGKIPWTLRGDMKFFSRLTsgteeagKQNAVVMGRKTWFSIPdrfRPLPKRLNVVLSRNLTTppEGAHHLAGSLEEAVKMLTEttvadtIDKVFIIGGNSVYKDALshPCCHRVYLTRVYKDVHCDTFFPNM--DDTFKLVSDptiPSEMQEENGIEYKYEVYEK-
>UniRef50_Q9U8B8(6-184:185) Dihydrofolate reductase n=1 Tax=Heliothis virescens RepID=DYR_HELVI   E=6e-12 s/c=0.40 id=36% cov=99%
-LNLIAAACDNMGIGVNGALPWRLKKEMAYFTTMTskVSEPtkvnaVIMGRRTWDCIPdkyRPLQDRVNIVLthnvdSVKENVPEGVMVFPGLDEAIKYIegrEDIESTWVIGGSSIYRAAMthPNCGKIYLTEIQKSFDCDTFFPNIDKQQFHLVDEEQIPGEKQveGNISYYFRVYKK-
>UniRef50_O62583(1-157:205) Dihydrofolate reductase n=1 Tax=Encephalitozoon cuniculi RepID=DYR_ENCCU  E=8e-12 s/c=0.46 id=40% cov=81%
MLALVVALASHRGIGNANALPWPRPlaADMAWFRTLSQSIPlispdrialapsasnaVVMGRRTWDSIPsrfRPLANRINVVLSRGPARSTENTFFIQTFEALDSLPLPPSSMtfVIGGRDVYSLALESGRPhlIFATEVFESPECDVFFPHI-------------------------------
>UniRef50_D1YEK5(3-146:156) Dihydrofolate reductase n=3 Tax=Propionibacterium acnes RepID=D1YEK5_PROAC  E=1e-11 s/c=0.49 id=35% cov=86%
----IAAVADNGVIGSGQDMLWHISEDFRRFKTVTMGHTLIFGRRTFEQIGK-LPGRRHIICTRDPhwsheGVDVATSPRQAVEMAREAGEEI--CFVAGGGQIYADTFELCDELDITEVHQNPNGAARFPAIDPEVWVEVRRESRD-----------------
>UniRef50_P17719(4-180:182) Dihydrofolate reductase n=21 Tax=Endopterygota RepID=DYR_DROME   E=7e-11 s/c=0.39 id=32% cov=99%
-FNLIVAVCENFGIGIRGDLPWRIKSELKYFSRTtkrtsdpTKQNAVVMGRKTYFGVpesKRPLPDRLNIVLSTTLQESDLpkgVLLCPNLETAMKILeeqNEVENIWIVGGSGVYEEAMasPRCHRLYITKIMQKFDCDTFFPAI-PDSFREVAPDSDmplGVQEENGIKFEYKILEK-
>UniRef50_Q93341(4-172:189) Putative dihydrofolate reductase n=2 Tax=Caenorhabditis RepID=DYR_CAEEL  E=1e-10 s/c=0.40 id=36% cov=85%
-MNLIVAMDAEGGIGKNGVLPWRIKKDMQYFASVTKNvsdqskrNAVLMGRKCWESIpvtRRPLAGRLNIVLSRQlpaQKSDDYIV-VNSLEAAMKLLSEPPfvdsieTIWNIGGAEIYDLALREnlVDEIHLTRIFKNFEADVHLKSLDFSKMEKV-----------------------
>UniRef50_C2CJZ1(5-158:162) Possible dihydrofolate reductase n=3 Tax=Anaerococcus RepID=C2CJZ1_9FIRM  E=2e-10 s/c=0.44 id=32% cov=91%
-------------IGKNGKMLFHIKKDLGHFKELTSGNICIMGRKTYESMGGALPNRENLILSRNKTYQapDALVFNDYRDIFSYLEDKDKEVFVIGGEKIVELFLDFCDEAIITKIYAERLADSFLHNFDSDDRWEVISK-SDIMEENGVSFQYIVYRR-
>UniRef50_Q98Q32(17-178:179) Dihydrofolate reductase n=1 Tax=Mycoplasma pulmonis RepID=DYR_MYCPU   E=8e-10 s/c=0.40 id=31% cov=92%
MIISIWAMTKEGLIGKDNQMPWHIKEEFQHFRRQTLHKTLIMGKNTFFSLPKVFDKRKMYVLSHEkdfkidhPDVEVIYDYKDLLKE--YANNDKKDIYVAGGLYVYQQLIPLSDILIVSIVKGSYEGNkylsvdfSNFVQYKQPEIYDQFSVYYykKKDQKNS-----------
>UniRef50_C7REN4(5-159:164) Dihydrofolate reductase region n=2 Tax=Anaerococcus RepID=C7REN4_ANAPD  E=9e-10 s/c=0.42 id=31% cov=91%
-------------IGKDGQMLFHIRRDLKHFKSYTLGNICIMGRKTYESMGGALTHRENIVLSRNKdyKAKDAKVFTDYRDVLSYVRERSEEVFVIGGEKIVEIFLEYCDEAIITKIYEKKDADSFLHNFdQDDDWS--LSEESDIMEENGVSFRYVRYRRK
>UniRef50_P00374(5-185:187) Dihydrofolate reductase n=50 Tax=root RepID=DYR_HUMAN   E=1e-08 s/c=0.34 id=33% cov=96%
----IVAVSQNMGIGKNGDLPWpPLRNEFRYFQRMTTTSSvegkqnlVIMGKKTWFSIpekNRPLKGRINLVLSRELKEPPQGAhfLSRSLDDALKLT-EQPELAnkvdmvwIVGGSSVYKEAMnhPGHLKLFVTRIMQDFESDTFFPEIDLEKYK-LLPEYpgvlSDVQEEKGIKYKFEVYEK-
>UniRef50_Q53D67(3-185:193) JM3 n=3 Tax=Macacine herpesvirus 5 RepID=Q53D67_9GAMA   E=3e-08 s/c=0.33 id=35% cov=96%
-------VAVDKQLGIgkNGTMPWpYLKNEMMYFQKMTSTpsvigekNVVIMGKRTWFSIpekKRPLANRINIILSRELREPPKGAhfLARTLDDAFnfyrqyKLTKQLNTVWVIGGKSVYESVLNYecSLKLYITRIMESFDCDVFFPSINFTEY-TMLSELPGKDTnfeENGIKYKFQVYEKR
>UniRef50_C5DEY6(8-221:237) KLTH0D10802p n=1 Tax=Lachancea thermotolerans CBS 6340 RepID=C5DEY6_LACTC  E=4e-07 s/c=0.26 id=35% cov=99%
IVTIVACLMPEMGIGYNGKLPWRLKQEMAYFRQVTsatfadgKRNAVIMGRKTWESIPpkfRPLPDRVNVVVSRQfaedlapaqssaPGSKlsshagaaapaSPALWLsnsltRCLDLLPQRVPDLERIYVIGGAEIYAQSNSLCDYMLITKI--EPESATERPPMDAFlDTQSIHALFqHDQSlpsflppavslpadpyiSENGYRYNFALYRRR
>UniRef50_Q4U9G5(10-198:523) Bifunctional dihydrofolate reductase/thymidilate synthase, putative n=7 Tax=root RepID=Q4U9G5_THEAN  E=0.0002 s/c=0.25 id=31% cov=99%
FVKILVAITPENGIGIKNGLPWpHIKRDfLFMFRATTYVDPefkekhpgaenvIIIGRNTYDSLPEsvfPLKNRINIVISRNltevPGGlvfSSIPSAIRHVTENlnyykifIMGIFNVVVLKYLGGSHVYREVLNAkiVDKMYVTRVNKNYECEVFFPKI-PDDF--VITGISKTFSSEDTSYDFVLYERK
>UniRef50_P11045(1-160:168) Dihydrofolate reductase n=23 Tax=Firmicutes RepID=DYR_BACSU   E=3e-71 s/c=1.68 id=44% cov=101%
MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGRKTFESIGRPLPNRKNIVVTSAPDSEfQGCTVVSSLKDVLDICSGPEECFVIGGAQLYTDLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK
>UniRef50_A7Z5T2(1-160:161) DfrA n=2 Tax=Bacillaceae RepID=A7Z5T2_BACA2   E=7e-70 s/c=1.65 id=37% cov=101%
MISFIFAMDENRLIGKDNDLPWHLPDDLAYFKKVTTGHTIVMGRKTFESIGRPLPNRRNIVVTsRDESSFPGCITADSAEEVLKLIPADEECFVIGGAQLYSALFPYADRLYMTKIHHVFEGDRFFPEFNEAEWELTSRKQGVKDEKNPYDYEYLVYEKK
>UniRef50_UPI0001787F40(1-162:162) Dihydrofolate reductase n=1 Tax=Geobacillus sp. Y412MC10 RepID=UPI0001787F40  E=1e-62 s/c=1.48 id=44% cov=100%
MISMIWAMGKDQVIGLNGTMPWRLPRDMAFFKEKTLHKTILMGRKTWDSFgGKPLPHRKNIVLTRDESFtltEDQGIVIHDIENALPYSKN-EELMVIGGSQIYELMLPKADRLYCTFIDESFEGDTYFPEVNWDEWKIVEEVPGITDEKNPYAYRFVTFERK
>UniRef50_Q2SXY8(56-216:219) Dihydrofolate reductase n=18 Tax=Proteobacteria RepID=Q2SXY8_BURTA   E=9e-62 s/c=1.47 id=42% cov=100%
-LTLIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIVVTRDAARRfDGCDTATSLGDALALAErdGAAEAFLIGGAQLYAEGLRHADKLIVTEIDQDFEGDASFPAPDPAQWEAVSRDAHRAAPPNDFAYAFVVYRRK
>UniRef50_C9BJS9(1-161:175) Dihydrofolate reductase n=13 Tax=Enterococcus RepID=C9BJS9_ENTFC   E=1e-60 s/c=1.45 id=35% cov=100%
MLAAIWAQDENGLIGKEDRLPWRLPNDLKFFKQMTEANTLVMGRKTFEGMGsRPLPNRQTIVLTRDSSYKaEGVHVMHSVEDVLALEKETDGIFFIaGGSAVYQEFLPFCTILYRTVIHHVFDGDAYFPPVDWSDWSLINTSQGEMDEKNRYPHQFETYQR-
>UniRef50_A4IUE2(27-188:191) Dihydrofolate reductase n=1 Tax=Yersinia ruckeri RepID=A4IUE2_YERRU   E=1e-60 s/c=1.44 id=43% cov=99%
IISLILAMADNGTIGDKNALPWHLPNDLQFLKKSTMGKPIVMGRKTYQSIGRPLPGRTNVVISRSLEKEalPGCLIYSDLSVAIAALKkepEVEEIMIMGGAQIYRAALPMMDRLYLTHVHANIEGDTQMPPFDFSHATLIFEEKHFKDEKNRYDYTFEIWD--
>UniRef50_UPI0000E87D66(4-160:161) dihydrofolate reductase n=1 Tax=Methylophilales bacterium HTCC2181 RepID=UPI0000E87D66  E=3e-60 s/c=1.48 id=39% cov=99%
-ISIIVAMSNNNVIGINNTLPWHIPQDLKRFKSLTMGNPIVMGRKTFDSIGRPLPGRKNIVITRNEDSiIEGVEIVNSINSLLALIKDEEHVFVIGGEQIYKIFLDHATHLYVTEVDSDVAGDAHFPKLSTSQWKEVGRE--KLVSKDDLHFSFVDYIRQ
>UniRef50_A5GBA2(2-156:163) Dihydrofolate reductase n=2 Tax=Geobacter RepID=A5GBA2_GEOUR   E=3e-60 s/c=1.50 id=45% cov=97%
VISLIAAMAENRVIGRNNAIPWDIPADRKRFRALTLGHPVIMGRKTFESLAGPLPGRKNIIITRQMDYrAEGCFIAHDLASALAMAGETDEIFICGGGEIYRQALPIADRIYLTIIHSRFDGDTRFPEI-PERFVEVGRETV----ENAIPYSFVLYDKR
>UniRef50_B8KL97(6-169:182) Dihydrofolate reductase n=1 Tax=gamma proteobacterium NOR5-3 RepID=B8KL97_9GAMM  E=4e-60 s/c=1.41 id=43% cov=99%
-IALIVAAADNDVIGRDNALPWQLPGDLAHFKRTTMGKPILMGRLTYESIGRPLPGRTNIVISRDPGYsAAGVRSVQSLEKALELAKDIavidgsSELMIIGGAQIYALALPLASRIYLTRVHVEPAGDAFLPAIDWAHWKESGRQENPADG-SVPAHTFLEYTRQ
>UniRef50_A6UB22(14-178:187) Dihydrofolate reductase n=18 Tax=Alphaproteobacteria RepID=A6UB22_SINMW  E=8e-60 s/c=1.39 id=42% cov=100%
-IVIVVAVALNGVIGREGDLPWRLPTDLKRFKAQTIGKPVIMGRKTWAAIGRPLPGRPNIVVTRNRAFEaPGAEVAPSLEAALAVAREraaaigADEICVIGGGEIYRQSIGMADVLHVTEVQAEVDGDTRFPEIDPAVFEKVLEEDLQSGEKDSHAMHFVTWRRR
>UniRef50_UPI0001698640(1-149:158) dihydrofolate reductase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001698640  E=1e-59 s/c=1.54 id=48% cov=93%
-------MARNRVIGRHNRMPWHLPADLRHFKALTIGKPIVMGRKTWESLPGLLPDRPHIVVTHNPSyYAEGCTLVHSIDEAIAAAGEVEEIMVVGGGAFYAEILPRVGRIYLTLVDAEFEGDTLFPDLDMAEWLECSRERHPADEKHTYPYSLH-----
>UniRef50_A2SN57(3-165:259) Dihydrofolate reductase n=34 Tax=Burkholderiales RepID=A2SN57_METPP   E=2e-59 s/c=1.40 id=43% cov=100%
-LAIIAACARNGVIGRNNDLPWRLPEDLAHFRSTTGGWPVIMGRLTWESLParfRPLPGRRNIIVSRGgvRGVPKGVDVVASLEAALELVQAERRAFVIGGARLYEAALPLADELFLTEIDEDFEGDVYFPEFDRSAFVEHHRMRRQAEAPNTFTYSFAHYRRK
>UniRef50_B3PTQ3(7-170:172) Dihydrofolate reductase protein n=49 Tax=Proteobacteria RepID=B3PTQ3_RHIE6  E=6e-59 s/c=1.39 id=41% cov=99%
--TIIAAVARNGIIGRDGDMPWRLSSDLKRFKALTLGKPVVMGRKTYDSIGKPLPGRPNVVISRQAAIDhPDVAMAHSLAEAMDAAErlaretGVDEICIVGGGQIYAQAINLADRMCITHVEADLDGDASFPDIDPDLWQAAETIAVPAGEKDSYPTRYVVYKRR
>UniRef50_P04174(4-159:162) Dihydrofolate reductase n=33 Tax=Neisseriaceae RepID=DYR_NEIGO   E=8e-59 s/c=1.46 id=41% cov=97%
-ITIIAACAENLCIGAGNAMPWHIPEDFAFFKVYTLGKPVIMGRKTWESLPvKPLPGRRNIVISRQADYcAAGAETVASLEVALALCAGAEEAVIMGGAQIYGQAMPLATDLRITEVDLSVEGDAFFPEIDRTHWREAERTERRVSSK-GVAYTFVHY---
>UniRef50_B1XTJ0(6-160:162) Dihydrofolate reductase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XTJ0_POLNS  E=2e-58 s/c=1.46 id=43% cov=97%
-ISMIVARSRNHVIGRDNQMPWKISADLQFFKRVTMGHPVIMGRKTWESIGRSLPGRRNIVVSRNASYPiSGGELVGSLDEALKSLNEFPRVFVIGGEQLFRQAFDKADRLYITEIDLDIEgGDTFFEVPNASAWKEVERTPGSEGE---ITFSFITLE--
>UniRef50_A3HTR7(3-163:166) Dihydrofolate reductase n=1 Tax=Algoriphagus sp. PR1 RepID=A3HTR7_9SPHI  E=3e-58 s/c=1.40 id=37% cov=99%
-ISLIAAVAKNGVIGKGNDLVWKIPTDFKRFKAITSGNYILMGRKTFESLGKPLPNRTHLVISRNKNYkvPEGHHLFENVEDAFIYCNklGIEKLYVIGGGEIYKQTISIADELLITEVDATPVGDTYFPEIDKNTWKIVSKESFPSDEINQHPFSFINYER-
>UniRef50_Q5P234(8-165:167) Dihydrofolate reductase n=14 Tax=cellular organisms RepID=Q5P234_AZOSE  E=8e-58 s/c=1.42 id=41% cov=99%
-VIIIAATARNGAIGRDNQLPWRLKSDLARFKETTIGHPVLMGRKTWESLGRPLPARRNLVVTRDRSYSAtGAEVFPDPEAALEAAGD-ETVFVIGGAELYRQLLDSADALLLTEVHADVAGDAYFPPFDRGDFDEVRREQHDADAHNEFSFDFVEYRRK
>UniRef50_C4L1C8(1-157:162) Dihydrofolate reductase region n=2 Tax=Exiguobacterium RepID=C4L1C8_EXISA  E=2e-56 s/c=1.39 id=35% cov=99%
MISHVVAYGQNREIGKDNDLLWRLPDDLKHFKAITSGGTVVMGRKTFESIGKALPNRRNIVVTSDvSFSADQVEVWHDLDR-LAEMSQQEEWFVIGGAMLYEQTMPMTSRIYATEVAASFEADTYYPE-QTGEWSVTSTIDHPQDETHAYAFSFKQYDK-
>UniRef50_D0XKH5(6-174:175) Dihydrofolate reductase n=1 Tax=Brevundimonas subvibrioides ATCC 15264 RepID=D0XKH5_9CAUL  E=3e-56 s/c=1.30 id=42% cov=99%
-IALVVARARNGVIGRDGDLPWKLRSDLQRFKQITLGKPCIMGRSTWESLPlRPLPGRLNLVLSRDLSYEErgkakGAVVCSNLADAIDMAREtaeddgIDEICVIGGTALFEAALPRAKRLYITEVEAEPEGDALFPAFDESLFAETLNERHDAGEKDDHPFVFRILDR-
>UniRef50_Q5HPB1(3-158:161) Dihydrofolate reductase n=24 Tax=Bacilli RepID=DYR_STAEQ   E=2e-55 s/c=1.38 id=37% cov=98%
-LSIIVAHDKQRVIGYQNQLPWHLPNDLKHVKQLTTGNTLVMGRKTFNSIGKPLPNRRNVVLTNQASFhHEGVDVINSLDEIKELSG---HVFIFGGQTLFEAMIDQVDDMYITVIDGKFQGDTFFPPYTFENWEVESSVEGQLDEKNTIPHTFLHLVRR
>UniRef50_UPI00017452A7(11-164:167) Dihydrofolate reductase n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI00017452A7  E=4e-54 s/c=1.38 id=38% cov=95%
-LIAIAAMASNRVIGRDGTLPWHLPEDLKFFKKTTAGHPVLMGRKTFESIvaalGKPLPNRRNIVLSSTLAPQEGVEVIPHLASLSQLSALTSPVYLIGGAQLYEALLPVCDELLLTWIDQPYEGDAFFPAF-EGDFSLREVLGHGEG------FEFRRYVR-
>UniRef50_B7H0P5(11-168:181) Dihydrofolate reductase type 3(Dihydrofolate reductasetype III) n=19 Tax=Acinetobacter RepID=B7H0P5_ACIB3  E=4e-51 s/c=1.28 id=36% cov=96%
----VVAMDKNHCIGKGNALPWHISADLKHFKEITQGGVVIMGRKTLESMGRALPNRVNWVITRDINWHfDGVKIAYSIEDALNAALEDAKntekqaLFIIGGGEIFKQTLSIADRLELTHVDLDVQGDAHYPTI-PSEFHKTASEQ-QVDEKSGTSFEFATYK--
>UniRef50_A5VJL0(4-159:162) Dihydrofolate reductase n=8 Tax=Lactobacillus RepID=A5VJL0_LACRD   E=1e-50 s/c=1.28 id=38% cov=97%
-LNLIWAEDLNGWIGKDNTIPWHVSADMKHFKTKTTGHPIIMGRRTFASLGnKPLPKRENIVLTSRNIDAEGVEVVHSLAALKEYLKANPnEYFVIGGATIYQQLLPMATKLTRTVINKQIVGDTKMPTIDYDRWHLVNHNNYEKDDQ--LICRFEEWE--
>UniRef50_UPI00016BFCBD(1-151:161) Dihydrofolate reductase n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016BFCBD  E=2e-49 s/c=1.30 id=37% cov=95%
---MIVAVSKNGQIGIANELPWNIKEDMNYFRKMTTAKTVIMGRKTFNSIGRPLPNRRNIVLTTNTDLKiAGVEVVTNFAEALIIARE-EDAFVIGGGQIYELFMPYAEELYITEVDIDIDGDAAFPEY-RNKFVCVETIEKSAN-DSKYNYRFTKW---
>UniRef50_Q2S5H3(21-181:186) Dihydrofolate reductase n=3 Tax=cellular organisms RepID=Q2S5H3_SALRD  E=9e-49 s/c=1.20 id=44% cov=96%
-LVIIAAVAEdNRVIGQDKDLPWHIPEDLKRFKQLTTGHPLLMGRRTFESIvhqfGGPLPDRKMVVLTTQDDYEayPEVDTYASVDAALAALPDDATVFIGGGESVYEQFLPHADRLELTLVEGAYEGDTFFPPFEHligDVFEETA-----VDARDG--FRFVTYERK
>UniRef50_D2RRK6(19-179:181) Dihydrofolate reductase n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RRK6_9EURY  E=7e-48 s/c=1.19 id=40% cov=94%
----IVAVADNGVIGKDGDMPWHIPADLKHFKETTMDHPIIMGRVTYEGIlealGEPLPGRTTVVLTsRDLETPENAVTARSLEEALEAAetaarerhDAADRIFVAGGATVYEQFLSALDRLIVTEVHEEPDGDTYFPDWDRASFDDVSRDDRDG-------FAFVEYVRR
>UniRef50_C8WAC3(1-160:162) Dihydrofolate reductase region n=5 Tax=Coriobacteriaceae RepID=C8WAC3_ATOPD  E=2e-44 s/c=1.12 id=31% cov=96%
----IVSVTRDWGIGCDGDLLIPNKADMKYFVEHTRSCTVIMGRKTLESFpGGPLKGRRNIVISRNTNYQvEGVEIVSSAEEALRLVKDEapEKVWLIGGASIYRALLDRCSYAYVTKHDTVVDADTYFPNLDEDpAWKVCNEEDGGVTPE-GVAFKFVTYQ--
>UniRef50_C2CJZ1(1-158:162) Possible dihydrofolate reductase n=3 Tax=Anaerococcus RepID=C2CJZ1_9FIRM  E=7e-44 s/c=1.13 id=30% cov=98%
-MKIILAVDKNWGIGKNGKMLFHIKKDLGHFKELTSGNICIMGRKTYESMGGALPNRENLILSRNKTYQaPDALVFNDYRDIFSYLEDkDKEVFVIGGEKIVELFLDFCDEAIITKIYAERLADSFLHNFDSDDrWEVISK--SDIMEENGVSFQYIVYRR-
>UniRef50_C5IWK1(3-156:157) Dihydrofolate reductase n=15 Tax=Bacteria RepID=C5IWK1_ECOLX   E=6e-42 s/c=1.11 id=28% cov=96%
-ISIMAAVSENGVIGSGLDIPWHVQGEQLLFKAMTYNHWLLVGRKTFDSMGK-LPNRKYAVVTRSEmvSNDPDVIYFTSIESALSYLDNtTTHVFVSGGGEIYKALIEQADVIHLSVIHKHISGDVFFPSV-PQSFKQTFEQSFSSN----IDYTYQIWAK-
>UniRef50_D1AYS8(1-153:156) Dihydrofolate reductase region n=1 Tax=Streptobacillus moniliformis DSM 12112 RepID=D1AYS8_STRM9  E=9e-42 s/c=1.11 id=34% cov=96%
MIHIVVAVGENNEIGKDNKMLWHNSEELRFFRKLTLNHKIVMGKNTYLSIGRPLDLRENIVISTTLEENEDIYVLRNIDKILEKYVDSDEiIYVIGGENIYKQFLKYTEKIYLSKIDGKFpDADRYFPSINYDE--------YSTEVVNYNTFKLYIYTRR
>UniRef50_A3DES9(1-159:167) Dihydrofolate reductase n=5 Tax=Clostridium RepID=A3DES9_CLOTH   E=2e-40 s/c=1.04 id=31% cov=97%
-MKAIVAVDSNWGIGYKGNLLQRIPEDMRFFRQMTLNKVVVMGRKTFESLPgkEPLKDRVNIILSKSENIEkDGIIICRSVDGLFLELKkyNSDDIFVIGGEEVYTQLLPYCSEAHVTKFNGAYSADRYFPNLDEmEGWKLV--CVGEPKEFNDIRYNRLKY---
>UniRef50_A8SSS6(1-160:168) Putative uncharacterized protein n=2 Tax=Bacteria RepID=A8SSS6_9FIRM  E=7e-40 s/c=1.02 id=30% cov=97%
-MKFIAAVDNNWAIGNKGSLLVRISEDQKNFRKETMGHVVVLGRKTLEEFpgGRPLKGRTNIILSTNPDYTVqDAVVVHSIDELFEKLSEYEsdDIFIIGGQTVYDVLIPYCDTGIVTKIDKSYEADAFIQNLDEmDNWH-VENERSGT-EPNDVNITFVTYK--
>UniRef50_P15093(6-157:162) Dihydrofolate reductase n=3 Tax=Halobacteriaceae RepID=DYR_HALVO   E=1e-39 s/c=1.07 id=35% cov=93%
----VAALAENRVIGRDGELPWpSIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSRseRSFSVDTAHRAASVEEAvdIAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYPEWDAAEWELDAETDHEG-------FTLQEWVR-
>UniRef50_B2GI60(1-179:183) Dihydrofolate reductase n=3 Tax=Actinomycetales RepID=B2GI60_KOCRD   E=2e-39 s/c=0.91 id=38% cov=99%
MVGAIWAQSPDGVIGVDGGIPWHLSEDLKFFARTTIGHPVIMGRRTWESFPeqfRPLPGRPNIVITSRPESvpadGERVWAVGSYAEALELAvsllaapgpeheEPAREVWVIGGPGVWREAVSHrplpLTRALVTTVDLDVTGDTHAPALDGS-WSR-REVAGWTEARNGTWFRIDEWTR-
>UniRef50_Q53D67(5-185:193) JM3 n=3 Tax=Macacine herpesvirus 5 RepID=Q53D67_9GAMA   E=2e-39 s/c=0.90 id=32% cov=98%
----IVAVDKQLGIGKNGTMPWpYLKNEMMYFQKMTSTpsvigekNVVIMGKRTWFSIPekkRPLANRINIILSRELREPPKGAHflARTLDDAFnfyrqyKLTKQLNTVWVIGGKSVYESVLNYeCSlKLYITRIMESFDCDVFFPSINFTEYTMLSELPGKDTnfEENGIKYKFQVYEKR
>UniRef50_Q6F181(1-144:161) Dihydrofolate reductase n=1 Tax=Mesoplasma florum RepID=Q6F181_MESFL  E=9e-38 s/c=1.09 id=28% cov=86%
MIKMIWAQTEKGVIGKDNSLPWSIKEEMQHFRTTTLNQNVLMGGKTFESMNfKGLPNRINYVLTRDTEKykehmSENVNFINKKDFILKEFKGntSKDVYIIGGSQIYELFFDDCDEIIRSMIKDDFEGNVHIKNFNYDNFDKI-----------------------
>UniRef50_Q7NHQ9(3-149:169) Dihydrofolate reductase n=1 Tax=Gloeobacter violaceus RepID=Q7NHQ9_GLOVI  E=4e-37 s/c=1.05 id=36% cov=90%
-LIAVVAMDSRRLIGRGDGLPWHCPEDLSAFKALTWGQPLLMGRRTFESIlarrGKPLPEREHYVLTaRRGPSFPTVRYICSPDQALAL--PVERLFVIGGASVYAQTADQLDTLYLSLIPGLHTGDVFLPDLG-NRWAVEIIEK------------FQTFKR-
>UniRef50_B3FJX9(4-179:183) Dihydrofolate reductase n=1 Tax=Pseudomonas phage 201phi2-1 RepID=B3FJX9_9CAUD  E=5e-37 s/c=0.88 id=35% cov=99%
--SMILARDVQGVIGIDNKLPWHVPADMALFIAHTKGKAVVMGRKTWESLPvKPLPGRHNIILTGKPNYKDvvnaeeltnkaQVSIASSVEDAIisASQEGADEVVFIGGRSIYDQVVNYVDEIHVSELNLCVETkgksdvDIYAQDFEDLGFVIASAGPLYESETGKHLLDYIRYAR-
>UniRef50_D2XB64(6-149:444) Bifunctional dihydrofolate reductase-thymidylate synthase n=1 Tax=Marseillevirus RepID=D2XB64_9VIRU  E=1e-36 s/c=1.06 id=34% cov=87%
---LVFACDQRGGIGNKGRIPWHLPEDLAIFQRMTFGRTIIYGRKTLESFPgsKPLAKRRNIIVSRNSDLNvDGAEVAHSLEEAFSLVQG--HCIVVGGSEIYKQCLEQFPDFCLgvsrTLVLETYEADTWF---------SVKEAKYNYLIKSSHNF--------
>UniRef50_C4QXY7(10-204:204) Putative uncharacterized protein n=1 Tax=Pichia pastoris GS115 RepID=C4QXY7_PICPG  E=2e-36 s/c=0.78 id=35% cov=98%
---IVAALIPGHGIGLKGKLPWSLKNEMKYFRLLTTNtisptskNVVIMGRNTWESIPsrfRPLQNRLNIVLTRNANisvengaaVDDSVLVADSLKnglDIIEKTGNIEEVFLIGGADLYNQCLAsgLVDRIFLTEVKslnGQIETDVSI-KIDPSQWIKQESQvlekylqdhgvngfQLDGNKEGELVYDFTLLERR
>UniRef50_A5E6H1(8-211:211) Dihydrofolate reductase n=1 Tax=Lodderomyces elongisporus RepID=A5E6H1_LODEL  E=4e-36 s/c=0.75 id=35% cov=99%
-ISIIVaALKPSYGIGNKGKLPWRLRKEMAYFKRVTlrtthTQNAVIMGRKTWESIPvkfRPLPDRLNIVLSRsfaNEEQENGVIHANSIGRCVELIKEKNllKVFIIGGSEIYHAFLRekgLVDYLLITEIEQDVknaEGkdkegktkeeevkevemDTFL-KFDTNEWvmgsQEELKEYTGETEietnvkEGDFTYNYTIWKRK
>UniRef50_Q4T3D4(4-184:185) Chromosome undetermined SCAF10097, whole genome shotgun sequence. (Fragment) n=5 Tax=Euteleostomi RepID=Q4T3D4_TETNG  E=3e-35 s/c=0.82 id=30% cov=99%
VLNAIVAVCPDLGIGRNGDLPWHpirLDNEFKHFRKMTstpsvngKQNVVIMGRKTWFSIPekhRPLANRINIVLSRRSRASSRSPPsgprpeLRSAAGGDAAGGQADQVWVIGGSSLYQEMMerPGTSRLFVTHVLKQFDCDTFLPEIRPQRYRLLPQfpgVPQELQEEKGIQYRYQVYE--
>UniRef50_Q4P9N0(37-215:291) Putative uncharacterized protein n=1 Tax=Ustilago maydis RepID=Q4P9N0_USTMA  E=8e-35 s/c=0.83 id=34% cov=81%
-LVMVAAMSLTNGIGKDGGLPWRLKGEMTYFRNVTshvadeeqrqgTRNAVIMGRKTWASIPpkfRPLAGRFNVVISRTSSATDlgirpeliaclhcihpnsdpdsnDARVFSSVEQALIHLATpqasISRVFVIGGAQMYTDLLDFhsslatVDKLLVTRILAPlYECDSFFPEF-------------------------------
>UniRef50_Q7NB76(1-154:592) Segregation and condensation protein A n=2 Tax=Mycoplasma gallisepticum RepID=SCPA_MYCGA  E=2e-34 s/c=0.95 id=26% cov=95%
MIKLIWCEDLNHGIAKNNQIPWKIDEELNHFHQTTTNHPIIMGYNTYLAMNKILANQANIVISkkhqRELKNKNELFLYSDLKKALIDFS-IVDLFIIGGKKTIEQAIKYADQLVISKLNADYGCD-LFVNLNYDDFSLVQTKEYDQ-------FVVEYWERK
>UniRef50_B9YC91(3-154:157) Putative uncharacterized protein n=1 Tax=Holdemania filiformis DSM 12042 RepID=B9YC91_9FIRM  E=3e-34 s/c=0.96 id=36% cov=94%
-ITMIAALDEVGGLGKAGRMPWHCPADLRQFQAYTMGKPLLMGRKTAEPLRRRLLGRQLIIQSRTMK-DPDFPVVRTVNEALAWMAarpEFDELVIGGGGEIYALWLPYAAHLRISRIAGRFDCDTFFPKWDPQEW--ICRKQSEEDG-----FLLEEWDR-
>UniRef50_C4LHD2(31-167:221) Bifunctional dihydrofolate reductase-thymidylate synthase n=1 Tax=Corynebacterium kroppenstedtii DSM 44385 RepID=C4LHD2_CORK4  E=4e-34 s/c=1.06 id=46% cov=74%
LIGVIWASDRDGVIGDGTRMPWHVPEDMAHFKQLTWGVPVIMGSATWSSIPSrftPLPGRTNIVLSRrwsDEDTPDGVILHHSLDAAFKdiphpvftrrVAPENVDAWVIGGGEVYREALtrPEVRLAVLTEIDA------------------------------------------
>UniRef50_D0LYN1(26-195:202) Dihydrofolate reductase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LYN1_HALO1  E=2e-33 s/c=0.84 id=29% cov=96%
---LVVVADLDGGIARKGEIPWHLSADLRHFQQLTRttaepaqQNAVIMGRKTWESLPaasRPLPSRRNIVLSRDAELTLPPGVVHAAELEAALAAtdlatpPIDRRFIIGGKGVYAEAMQRrgCRHIFYTEIQDRFDCDLFFPAF-KDRFKRTD--LLAEGEEKGIGYRIEVWTR-
>UniRef50_Q0FG98(1-132:159) Dihydrofolate reductase n=1 Tax=Rhodobacterales bacterium HTCC2255 RepID=Q0FG98_9RHOB  E=2e-33 s/c=1.08 id=35% cov=80%
MIKAILACDDEWGIGKNGDLPWpHNPADLRWFKNNTLNSVIVMGKSTWDSLPRkPLPNRENLIVTTSKqefGYDDyEFINFSDLEVKLSSTKDINNIWIIGGAKLISGLINFIEEFHLSRINGNFNCDTFLP---------------------------------
>UniRef50_Q28J42(11-190:197) Dihydrofolate reductase n=5 Tax=Euteleostomi RepID=Q28J42_XENTR   E=3e-33 s/c=0.79 id=27% cov=99%
-VKLIAAACNSMGIGLNGYLPWNLPNEFKYLLDTITrvtqpGKKnlLLWGRQSFETFDEsllPLPNCIIALLSRKLSTvPPYVSYLCKNEEEILKFAstpplndEIETIWVLGGVESYKNLMqhPWCNHIYFTKIMADFECDTFFPEFDKNIFKLKENfpgVPSGIQEENGVKYVFQVYQR-
>UniRef50_P36591(234-417:461) Dihydrofolate reductase n=2 Tax=Schizosaccharomyces RepID=DYR_SCHPO   E=1e-32 s/c=0.76 id=29% cov=91%
-LTMIVAVsSPNLGIGKKNSMPWHIKQEMAYFANVTSStessgqleegkskimNVVIMGRSCYDSLPkknRPLKDRINIVITRNSNYNfgltkkekmpENLYAADCIDSALDLVAEkygadsdiqVGKVFIIGGSFLYGSALyhPLTKNLLFTRIHKEYPCDSFFP-FEPAESSDWVRKAHPELEK-------------
>UniRef50_P47470(1-156:160) Dihydrofolate reductase n=2 Tax=Mycoplasma RepID=DYR_MYCGE   E=2e-32 s/c=0.90 id=24% cov=94%
MLIAIWAMTQEGLIGNNNTLPWMIKQELAHFKKTTLFQALLMGRKTYESLPKVFEKRTIFLLSKDQNYrfEEKGSEVKVINDFWPLiksyqANKEKDLFICGGKSVYEQTINECDQLIVSIIKKKYKGDQFL-KVDLSKFVLNEVVEFEEFNVNYYR---------
>UniRef50_C0VSW2(1-166:167) Dihydrofolate reductase n=2 Tax=Corynebacterium glucuronolyticum RepID=C0VSW2_9CORY  E=8e-31 s/c=0.81 id=34% cov=95%
-MKAIWAQSRDGIIGDGSTMPWYLPEDLHHFKNTTMGEDILMGRKTWESIGsKALPGRTNLVLSTREpgDWSAGATVVSSVPADFDG-------WLIGGGSLYQSLYPRLSRIAVTLVDVlldgllatpvtvpSVTSDPAFSHTVDGIWQ-TSAKGSFAHTDGPVHYAFHEYTRK
>UniRef50_Q4A320(6-190:480) Bifunctional dihydrofolate reductase-thymidylate synthase n=2 Tax=dsDNA viruses, no RNA stage RepID=Q4A320_EHV86  E=3e-30 s/c=0.72 id=29% cov=99%
-VCIVVAGAKcsDGriAIGINNKIPWNSKADMHNFRQLTTStsmpiceNVVIMGTKTWQSIGKRLPNRYNIVISRNKDArrvyniPNNVGISSSIELAISELKtvsDIETIYVIGGSYIYKDVIDLkiVDKIHMTFVSNQHDpgafdnCDTFFPlTVNDLESNFIKSKTSYVTKEAHLTCSYHTYK--
>UniRef50_A8GUE9(6-136:167) Dihydrofolate reductase n=8 Tax=Rickettsia RepID=A8GUE9_RICB8   E=7e-27 s/c=0.92 id=31% cov=79%
-ITGIMACDPKGVIGLKGRMPWSYPEEFEYFYQIVKNNIIVMGHKTFDSLpPKILQNCICIVFSRNtPTSDNDVFFVESLDEFWQVIEifADKKIFMVGGAEIATFFLKQnlLDEFLLTRINNDYEGDAFFP---------------------------------
>UniRef50_D2CLW7(37-234:641) Dihydrofolate reductase-thymidylate synthase n=75 Tax=Plasmodium RepID=D2CLW7_9APIC  E=3e-26 s/c=0.60 id=31% cov=92%
-----------RGIGNKGILPWKCnSVDISYFSSVTTyvnewnykklkykrekylekdisndkkkvdviniapiskklQNVVVMGRSSWESIPksyKPLANRINVVLSStlkKEDVKEDIFIMKSMDEVllLLKKLYYYKCFIIGGAGVYKECLERnlMKQIYLTRINNTYECDVFFPDMDENAFQITS--VSEVYSSNGTTLDFLIYSRK
>UniRef50_A7XFK8(1-191:193) Frd dihydrofolate reductase n=3 Tax=unclassified T4-like viruses RepID=A7XFK8_9CAUD  E=1e-25 s/c=0.61 id=29% cov=99%
MIQCVFAIgdtkmsDENWAFGFKGGLPWgrPIKKDMENFKMRTMGDvelaAVVMGRNTFESLPKALEGRVNVVVstdTSKPAPKAKNGEQPDVYTAITNDGGLKEllevieklqglVSVIGGPSLIEKAVDFADRIVLTYVQRSGINDPF--EYDVGISKEMIQElYFDFVTKEEHNYFLdnyliseQILERK
>UniRef50_Q6WIE5(20-139:181) Dihydrofolate reductase n=1 Tax=Vibrio phage KVP40 RepID=Q6WIE5_BPKV4  E=7e-24 s/c=0.93 id=38% cov=67%
--------------GNQNALPWkHNKEDLVRFKAATMNSVLVMGSKTFESLPGKLPHRPHIVLSSSDTATArngqRADVYCSCDDFGALIKNIENVYliegfdkisVIGGPSVIESALPFADCIYKTTIVEEIE---------------------------------------
>UniRef50_B8M2L8(40-231:285) Dihydrofolate reductase, putative n=1 Tax=Talaromyces stipitatus ATCC 10500 RepID=B8M2L8_TALSN  E=1e-23 s/c=0.57 id=33% cov=82%
------------GIGLNGTLPWpRIKSDMNFFARVTSRppssgdgsgsgngkekiNAIIMGRKTYYSLPkglRPLKDRLNVIISRDehgtvsteihqdltrqkeksrtdgKEDKRDAFVAHSFDSALTQLFDKHRrqdlgyVYVIGGGEIYKSSLELevslsskiVQRILMTRIKrrdgEKYECDTFFPLTDEDLSTSTGGEKG------------------
>UniRef50_D2W4C0(20-245:535) Predicted protein n=1 Tax=Naegleria gruberi RepID=D2W4C0_NAEGR   E=4e-23 s/c=0.48 id=35% cov=98%
----VVAVLLNsNGIGLNGNLPWlqdGLTEDMKHFVSVTCSseplkfispsmykqssssspitsdntndntttindqlmNAVIMGRKTWESIPskfKPLsKNRHAIILSSKVNDDDQLmmertTFVKNVDELFELLQNQKfnRIFIAGGTSIYKLLLPYTAVIHYTNIieqkGVNIQVDTRFPirllpssdyrnvPINSNQFIAVDKSDKILPKNNEriSHYEFITFERR
>UniRef50_Q5UQG3(5-193:563) Thymidylate synthase n=1 Tax=Acanthamoeba polyphaga mimivirus RepID=DRTS_MIMIV  E=8e-22 s/c=0.55 id=34% cov=97%
---IIAAINNDSIIGVKEygtfSMPWpYLKDDMNHFRKITTDtgsiesgvNAIIVGFNTWQTLPSSYRNirsRFNIVISRDDETDGQFHkYVKTFDEAIEFASsltNLNEIFVIGGGVIYDLALKHklLDKLYLTHVGSNYPIDdnvekvVHFPltwskieKMCDSNFLELDSEISKHDIGKNILLRFQEY---
>UniRef50_C3WA87(6-160:161) Dihydrofolate reductase n=1 Tax=Fusobacterium mortiferum ATCC 9817 RepID=C3WA87_FUSMR  E=1e-21 s/c=0.66 id=25% cov=90%
-INMIVCVAENNLIGdknpTGNGLLWHSKEELAYYKERTIGNVVIFGKNTAKYVPLELmkKNRDVIVISSKDSFYEIVERYKDTD---------KKIFICGGATVYKAYLEKypLDNIYISKLKSHIEVTIpnnplYFPNVEEFGYSVVEVKEYQ-------DFTAYTYKKK
>UniRef50_B2YFY8(3-152:170) Dihydrofolate reductase n=1 Tax=Musca domestica salivary gland hypertrophy virus RepID=B2YFY8_9VIRU  E=2e-21 s/c=0.69 id=27% cov=78%
-LILIAAIARNNIIGVStSSLPWHIRDEMQFFKSIITNRwhlnpqthglhlrpspnvgkiAYIMGRNTYNAMP---PITSSIVVGR--------LHHPTVDKAIEHARhhmQADTVFVLGGSRIYDECLRRqlCHRLIISRIHNSYDGDIFMPPINTQKYRL------------------------
>UniRef50_Q56BY6(14-172:193) Frd dihydrofolate reductase n=1 Tax=Enterobacteria phage RB43 RepID=Q56BY6_9CAUD  E=4e-20 s/c=0.62 id=29% cov=91%
------AYDEDFAFGYQQGLPWgHCKEDLQNFKAETANSVLIMGANTFTSLPGKLPGRVHCVLsasgqrlvTKNGNTADYIIHCGGLSAAIdvmKATHPDSDVCIIGGKGLLLEAINntLVDELVITHVygHRVYNA----PAFKRDVSFSV-KEFYDAVLKYGY-CDFET----
>UniRef50_A2QZD9(7-229:273) Catalytic activity: 5 n=6 Tax=Trichocomaceae RepID=A2QZD9_ASPNC   E=2e-19 s/c=0.43 id=29% cov=88%
-ITLIVATTPiptegssiRLGIGHSGTLPWpRIKTDMSFFARVTsrpptpgTTNAIIMGRKTYDSVPahlRPLAKRISTIITRDVDSltervgrevevrrekiaasaaasasaggnggnaeqpATDAIVCGGLNDALQQLetrygeeGKLGKVFVIGGAEIYGAVLAAGKdvwggpvRIVMTNVEKKgyaegnkgevFECDTFFPVDEElfgekEGWRKVSAEE-------------------
>UniRef50_C5CHN8(3-125:179) FolA n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=C5CHN8_KOSOT   E=5e-18 s/c=0.75 id=40% cov=67%
-ISIVAVNSVNGLISRDSdyDVDWSSPDDRKFFKKITTSaGVVIFGRRTFETIGKPLPKRLNVILTRTPEK------FHSTENLL-FTNDEPEIliskigrlgfkhIVIGGGrEIYTLFLknKLVTDIYLS----------------------------------------------
>UniRef50_UPI0000D9B01C(87-205:207) PREDICTED: similar to Dihydrofolate reductase n=1 Tax=Macaca mulatta RepID=UPI0000D9B01C  E=3e-14 s/c=0.67 id=25% cov=53%
--------------------------------------------------------------------------ARSLDDALKlteqpeLANKVDMIWIVGGSSVYKEAMNHPGhlKLFVTRIMKDFESDTFLPEIDLEKYKLLPEypgVLSDVQEEKGIKYKYEVYEK-
>UniRef50_C0QKC0(3-126:167) FolA n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QKC0_DESAH   E=6e-14 s/c=0.64 id=28% cov=72%
-VILVMAMTLDGKIARDsNHSAdWTGKDDKKKFVEITKRaGAMIMGSKTFDTIGRALPGRKNIVMTRNRSRKsDGNLIFTDqPPDLILKGLDREgfsEVALIGGTQInslFAQA-NLIDEIFVTVV--------------------------------------------
>UniRef50_C5AIT6(8-45:109) Dihydrofolate reductase n=1 Tax=Burkholderia glumae BGR1 RepID=C5AIT6_BURGB  E=6e-08 s/c=1.54 id=36% cov=25%
---LVAAMAANRVTGLGSDIPWRIPREQKRFRELTMNQ-LVM---------------------------------------------------------------------------------------------------------------------
>UniRef50_C6CWT2(43-122:169) Dihydrofolate reductase-like protein n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CWT2_PAESJ  E=1e-05 s/c=0.64 id=32% cov=41%
----------------------------------------IVGRRTFEGMrgnGGPGPfGEVDIViISKSASDIPGVTVVRSPEEALNHLrqKGHQTALISGGAEIHNSFL-------------------------------------------------------
>UniRef50_B1YFZ5(46-120:173) Bifunctional deaminase-reductase domain protein n=2 Tax=Exiguobacterium RepID=B1YFZ5_EXIS2  E=2e-05 s/c=0.67 id=30% cov=42%
--------------------------------------AVIMGRKTFDevlvlSEEYPYPAIDNYVLTRQNGKQSEHATFTNepLDVLLERISPsiDGKIWLIGGGELIQEAL-------------------------------------------------------
>UniRef50_C1E922(144-241:287) Predicted protein n=1 Tax=Micromonas sp. RCC299 RepID=C1E922_9CHLO   E=0.0001 s/c=0.49 id=30% cov=48%
--------------------------------------AVLMGRRTFDQvaefvvrdkVPWPYEGKRVIVVSRTMTQKDvpeplssKVTVtAQSPSEALKALGKtgfTRRVYVDGGMTI-RSLLeeDQVDEMVLTSV--------------------------------------------
>UniRef50_C6VJR8(9-175:179) Reductase (Putative) n=3 Tax=Lactobacillus plantarum RepID=C6VJR8_LACPJ  E=0.0003 s/c=0.28 id=30% cov=85%
------AISIDGCLAtKDNRLDW-------LFK--TAGandapteafmqqvDTAIMGRHTYEYMMEqttdqlinPYnPATHNIVMTSHPHTGDErtqftNTPVTKIVEDLRRTAG-KNIWIVGGAGVLMPLLaaDLVDELYI-QIAPVILGDgiPLFKAIDQQQrFELVDTNRYGQLAE-------VHYQR-
>UniRef50_A4U111(9-124:172) Dihydrofolate reductase n=1 Tax=Magnetospirillum gryphiswaldense RepID=A4U111_9PROT  E=0.0005 s/c=0.39 id=22% cov=63%
------AASVDGYIAtADGGLDWLEPydgSDFGYDRLMAEVEVVVVGRTTFDliaGFPaWPYPGKRVVVLTHRPLLSPPAGVECHAGDVAALTERlrrqcSADIFIDGGAQTVRAFLD------------------------------------------------------
>UniRef50_A4Y040(11-174:176) Dihydrofolate reductase n=28 Tax=Proteobacteria RepID=A4Y040_PSEMY   E=4e-55 s/c=1.31 id=50% cov=99%
-LSLIAALADNRVIGRDNQLPWHLPADLKHFKALTLGKPIIMGRKTWDSLGRPLPGRLNIVVSRQAGlTLEGAEVFATLEEAIKRAdawareEDAEELMLIGGAQLYELGLEQADRLYLTRVGLEPEGDAFFPQIDESAWRMTSSVEHPASAETPF-YAFEVWERR
>UniRef50_C2FZ23(6-164:164) Dihydrofolate reductase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FZ23_9SPHI  E=1e-53 s/c=1.32 id=44% cov=100%
-ITLIVAAAENNVIGKDNQMPWHLPNDFKYFKKNTLEHSVIMGRKTFEAIGKALPDRRNIVISRNQDFhHPDVDTANSLQEAILYCRDEREVFVIGGANIYEQTLPFAHKVLLTRVHTTIEGDAVFPVLNPEEWMLESEEKHFADDKHAFDYTFQVFNRK
>UniRef50_C6P459(19-176:177) Dihydrofolate reductase n=1 Tax=Sideroxydans lithotrophicus ES-1 RepID=C6P459_9PROT  E=3e-53 s/c=1.32 id=34% cov=99%
-LSLIVAMARNRTIGVNNTLPWRCPEDLKHFKTLTMGHHMIMGRKTFDSIGKPLPGRTTVVITRNNDLEiEGCIVAHSLQEALVTCAGDEEIFVVGGAELYRQAISLVDTLYVTEIQQDVAGDAHFPEIDKAFWQETSREMRSQETPQPMDFHFVTYRK-
>UniRef50_C7PKU6(3-162:164) Dihydrofolate reductase n=1 Tax=Chitinophaga pinensis DSM 2588 RepID=C7PKU6_CHIPD  E=2e-52 s/c=1.29 id=38% cov=99%
-LSIIVAASENNVIGINNHLPWHLPVDMKYFKDTTMGKPIVMGRKSFEELGRVLPGRPNIMITRQKDYtAEGLHIVPSLEAGIEKAKtfGTEEIFVTGGGEIFKMALSIVDRVYLTRVHATVQGDTYFPEFDPRGWKLVKNERHEKDEKHAHALTFQVWER-
>UniRef50_Q15PF1(4-171:171) Dihydrofolate reductase n=18 Tax=Gammaproteobacteria RepID=Q15PF1_PSEA6  E=5e-52 s/c=1.22 id=51% cov=99%
-IAMVAAMANQRVIGLNNQMPWHMPADLKHFKRITLGKPIVMGRKTYESIGRALPGRLNIVITSDQNYQlADASIVHSCEQAIAVAtshmqndgmpEHDQEVMVIGGGTVYQHFLPHANRLYLTFIDLDTPGDTYFPNYSDGAWQEIESESNDPDEKNPHSYRFVTLAR-
>UniRef50_A5EUV9(6-164:164) Dihydrofolate reductase n=1 Tax=Dichelobacter nodosus VCS1703A RepID=A5EUV9_DICNV  E=1e-51 s/c=1.28 id=40% cov=100%
-IHLIAAQTLNRVIGKDGGMPWHLPRDLQHFKQRTSGHTIIMGRKTFQSLKKPLPNRKNIVISHSGQpLHADVAVFPAISEALAFCCNDEKVFIIGGGSLYAATIDEADFLTITWIHTELLGDTFFPPIRPQDWQETHRSHFAADAKNAFALDFVDYQRR
>UniRef50_B9ECC1(2-157:164) Putative uncharacterized protein n=1 Tax=Macrococcus caseolyticus JCSC5402 RepID=B9ECC1_MACCJ  E=4e-45 s/c=1.17 id=38% cov=98%
IISLIAAISSNYVIGKDKDIPWKIPGEQVRFKDLTMGKSVIMGRKTFESIGQPLPNRKTIIISKSKDINyNNCLTVESLERAFNLLQQEDEIFIAGGGEIYKESLPFADRIYLTIIEKEYEGNIFFPMFNKDEFEITYQQKV----EGFIPYTYFTYERK
>UniRef50_Q5HFZ7(3-158:159) Dihydrofolate reductase n=54 Tax=Staphylococcus aureus RepID=DYR_STAAC  E=3e-44 s/c=1.15 id=35% cov=98%
-LSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNvEGVDVIHSIEDIYQL---PGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK
>UniRef50_A1SJ32(8-150:160) Dihydrofolate reductase n=1 Tax=Nocardioides sp. JS614 RepID=A1SJ32_NOCSJ  E=1e-43 s/c=1.24 id=38% cov=89%
-VVLVAAVARNGVIGDGPDIPWQLPGEQRLFKGLTWGHILVMGRATYDSIGRPLPGRTTIVLTRSPDWsAEGVHVAHDLPAALALADTLEgEVMVAGGGQVYAAALPVADEQVLSEVDLEPQGDAFYPEFDRSEWRETAREQHD-----------------
>UniRef50_Q18HG9(37-193:195) Dihydrofolate reductase n=4 Tax=Halobacteriaceae RepID=Q18HG9_HALWD   E=1e-42 s/c=1.10 id=45% cov=92%
-----AAVAANDIIGRDGEMPWHIPADLQQFKRRTMGHPVILGRRTYEAIigalGEPFPGRTSIVLSSQSrDVPADVILVHSITSAIREASKNARergvgtVYVAGGGGVYEQFLPLADRLRLTELHDEYEGDTKFPSWDDTVWQETTREKNE-------TFDFVTYER-
>UniRef50_UPI0001874368(15-173:176) dihydrofolate reductase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI0001874368  E=2e-40 s/c=1.04 id=38% cov=98%
-VGMIWAQSRAGIIGDGATMPWHLPEDLQHFKTTTMGAPVIMGRRTWDSLNpkfRPLPGRRNIVLSRSVSDFPGAESATSLEAALAAVADEPAAWIIGGGRVYRDALSLADECVVTDIDTDVS--VPVPVMAPDLYDWVRVEDGPwQTSTTGLRYRFCTWQR-
>UniRef50_Q9CBW1(3-164:165) Dihydrofolate reductase n=25 Tax=Actinomycetales RepID=DYR_MYCLE   E=3e-40 s/c=1.02 id=37% cov=98%
VVGLIWAQSTTGVIGRDGGMPWRVPEDLTRFKQLTMGHPVVMGRRTWDSLPvgvRPLPGRRNIVLSRQIDFmAEGAEVFGSLEETISNLETEPEMWVIGGEQIYRLALPLATRCGVTEVDTYLlheDDDVLAPVLD-DTWVGVTGEW--LVSCSGLRYRLHSYHR-
>UniRef50_B8DW85(37-217:227) Dihydrofolate reductase n=6 Tax=Bifidobacterium RepID=B8DW85_BIFA0   E=8e-40 s/c=0.91 id=41% cov=99%
-VNLIWAQANDkegrsGAIGYEGEMPWHLPEDLKRFKELTVSHPVIMGRKTWEALNekfRPLPNRDNIVLSRDRDFrAPGATVVDNLEEALDMARqeaipddglDRSEIWVIGGSQLFNQMLPMASKIYMTQVDAKVNADAYAPDlteaLNNGSWKLMENSGWltPKKPEGIDRYRYLTFER-
>UniRef50_Q13PE2(7-158:171) Dihydrofolate reductase n=1 Tax=Burkholderia xenovorans LB400 RepID=Q13PE2_BURXL  E=2e-39 s/c=1.07 id=40% cov=95%
-VVLVAAMAANRVIGLGNDIPWRIPGEQKRFRELTMNQLVVMGRRTFESIGKPLPGRDLLVLSSGTSRLGTVRTVKSFAEVTAAVNNDPReaIFVGGGQQVYAMLMPYADVVYLTEIDLRPPGDAFFPEI-PERFSLPDSVDFP----GEIRYTFNTY---
>UniRef50_Q59487(1-164:168) Dihydrofolate reductase n=17 Tax=Streptococcaceae RepID=DYR_LACLA   E=2e-39 s/c=0.99 id=32% cov=100%
MIIGIWAEDEAGLIGEADKMPWSLPAEQQHFKETTMNQVILMGRKTFEGMnKRVLPGRISIILTRDETYQsdnEKVLIMHSPKEVLDWYhKQNKDLFITGGAEILALFESELELLYRTVVHEKFKGDTYFPStFDFGRFKLVSEKFHDKDERNSYTFTIKKYEK-
>UniRef50_C7N8V9(1-170:173) Dihydrofolate reductase region n=5 Tax=Fusobacteriaceae RepID=C7N8V9_LEPBD  E=1e-38 s/c=0.94 id=36% cov=96%
MFSLIVAVGENNEIGKNNQLLWHIPEDLKNFKKITMGKTVIMGKNTYKSIGKPLPNRKNIVLSRNPLEIEEkikedrkkyenentkLELCDNLQKIIDKYKNsEEEIFIIGGGEIYKKAfeMKIVKRIYMSHVNfSDKNADTYFPKIDLKKWVVITKENYDG-------WRFCIYEK-
>UniRef50_D1YEK5(3-155:156) Dihydrofolate reductase n=3 Tax=Propionibacterium acnes RepID=D1YEK5_PROAC  E=2e-38 s/c=1.04 id=33% cov=93%
----IAAVADNGVIGSGQDMLWHISEDFRRFKTVTMGHTLIFGRRTFEQIGK-LPGRRHIICTRDPHWsHEGVDVATSPRQAVEMAREAGEeiCFVAGGGQIYADTFELCDELDITEVHQNPNGAARFPAIDPEVWVEVRRESRDG-------FDFVGYRRR
>UniRef50_C7XU42(3-161:166) Dihydrofolate reductase n=1 Tax=Lactobacillus coleohominis 101-4-CHN RepID=C7XU42_9LACO  E=9e-38 s/c=0.99 id=29% cov=98%
-ISFVWAEDEAGWIGKNGQLPWHLPVDLKHFKTVTDHHPIVMGARTFASIGRPLPNRPNIVVSHHPVAVDQVITVTNIEDLMNLifkrYADQEEVCIIGGAGLFAQMVAHVNCLHRTIVMGNHHGDVKMIPIDYHQWQLTKKTPVYNSKTGALNCYFEEW---
>UniRef50_C0EGY7(1-165:319) Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum DSM 5476 RepID=C0EGY7_9CLOT  E=2e-37 s/c=0.95 id=34% cov=99%
MIKMkcIVAVDQAWGIGCENGLLYSIPEDMAFFRKTTLNKAVVMGRHTLESLPksRPLKNRLNIVMSRDRSLQiGGAITCCSLQDLGVALSicDSDDVYVMGGYAVYSLLLDFCGQALITKIQGQREADRFFPNIDRDnNWTL--SEQSDVRSHNGLCYSFCVYANK
>UniRef50_UPI000186EC32(6-181:190) Dihydrofolate reductase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186EC32  E=2e-37 s/c=0.89 id=35% cov=97%
---LIAAVCSNNGIGYKGNLPWNLRKELQYFNRMTKDvknpekkNAVIMGRKTWDSLPhnwKPLPGRYNFVLTTQSLNLDGAVVCSDLNDLIKKINSpdysnlIETAWVIGGSKVYESVLKYglCHRFYLTRIKKEFECDCFF-NYDFTkDFKEVSDDRVPKgvQKENEIEYVFHVYEK-
>UniRef50_Q7VQK5(2-167:168) Dihydrofolate reductase type I n=1 Tax=Candidatus Blochmannia floridanus RepID=Q7VQK5_BLOFL  E=6e-37 s/c=0.93 id=40% cov=100%
IISLIAAFTINYVIGRKNIIPWYFSWDMMWFKYHTMYKPVIMGRKTFESMNsKPLPYRLNIVLSKHHilynNKIHNIFIACNPIQALSVVQKNDEVMIIGGGLVYNAFMSQCTRMYLTKIDVVYNyGDSWFPSYNPNEWCVVYNTNKKCVINTGYTYnlNFQILDR-
>UniRef50_C3PEY4(1-178:181) Dihydrofolate reductase n=9 Tax=Corynebacterium RepID=C3PEY4_CORA7   E=7e-37 s/c=0.87 id=34% cov=99%
MLGAIWAQSLDGVIGDGVVMPWHVPEDLKHFKEVTMGAPVIMGRKTWESLtpkFRPLPGRDNIVLSRREpgEWSAGATVVDNLDAAL--HATLDDAWIIGGGQLYSSALDRVDTIELTlmgvQVGDAYGADAVLAPSVPEEFSLSADSDWLTSEsghltipgqppsELPMKYRFLTYDRK
>UniRef50_C8NZB9(1-149:150) Dihydrofolate reductase n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8NZB9_ERYRH  E=9e-37 s/c=1.03 id=29% cov=94%
MIKIIVAMNNHRTIGLNGSMPWHNKEDLQHFRKSTLNQKVVMGRKTFEGLPKKLDNREIYVVTRNASIENAIPDLRAF--LMQHKESSEDIFIAGGGEIYAQSLPFAHELIISYIPNDVIGDTFFPDFSDLEFKIKNQVEYS-------TFKQVTYER-
>UniRef50_C4V3M4(167-321:322) 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase protein n=1 Tax=Selenomonas flueggei ATCC 43531 RepID=C4V3M4_9FIRM  E=9e-37 s/c=0.99 id=32% cov=94%
-LELIAAVDDAGGIGRAGHLLTDCPEDMAHFRRMTMGGIVVMGRRTMESLPgrRPLVGRMNIVLSRTMQETDGFYAAADILALWRLlgrltAEEARPIFVIGGAACYRLLLPYVWRAYVTRLLGSYDADVFFPSLD--GFSMTSSSAGQ-------DCIFEVYER-
>UniRef50_C0VZ67(3-170:170) Possible dihydrofolate reductase n=3 Tax=Actinomycetaceae RepID=C0VZ67_9ACTO  E=1e-36 s/c=0.91 id=33% cov=100%
VVKMIWAQDAEGKLGSGSEMLWHVPADFRHFKQSTVGFPLIMGRKSWDALGRfaPLPQRRNIVVTRNRDFiPEGGEVAFSIEEAISLASADSElVWIAGGAHIYEQAMPFADELVVTYLDLNVSTAgpvVYAPQIDPAVWEVVKAE-SDADwrEKSGdARWKVVVYRRR
>UniRef50_Q27828(8-166:462) Thymidylate synthase n=1 Tax=Paramecium tetraurelia RepID=DRTS_PARTE  E=8e-36 s/c=0.95 id=28% cov=98%
--SMVLAMTLNGGIGYQNRLPWKLKEDLQRFKKITTGGIVIMGRKTFESMNsKPLPNRVNVVISKNMKSSNEVQVFPRIEDALQFYNTsHQKLYLIGGKRIFEEGLatDKCSDVHLTRIGVETKCDVYLNKNIFSTFQV--NKTSQTKSENGINYDYQHLINK
>UniRef50_Q86ZU9(4-203:205) Dihydrofolate reductase n=2 Tax=Agaricales RepID=Q86ZU9_COPCI   E=2e-35 s/c=0.74 id=30% cov=99%
-LTIIVAATKANGIGKGSNLPWRLAKEMKYFARATseapegTRNAVVMGRTTWESIPekfRPLPNRVNVVVSRNENYElepgkepsPMARLANSLSSGLRHLTTTDgltvnRIFVIGGASLYRETLslarsktgPFVDRILLTRIvEPDFDCDVFMPEFNADgkEWTRSthaelqewvgFSVPEGIQEENGVKYEFQMWTR-
>UniRef50_C2D6N3(11-184:186) Possible dihydrofolate reductase n=1 Tax=Atopobium vaginae DSM 15829 RepID=C2D6N3_9ACTN  E=2e-35 s/c=0.86 id=27% cov=99%
MIKAIVSVTQDWGIGYKGELLVPNKADMQHFVRMTTGACVIMGSTTFETFPKgPLKNRRNIVLAQTHSYERegfpkttcteqgtsvqNYEVYTSTQDALSHIKPDEDVWIIGGAYTYQQFLPYCTEVVVTKNDCIRQADAYFPNLDKmDDWRITSTTEGGITSE-GVHFLFVTYQ--
>UniRef50_Q59397(4-165:177) Dihydrofolate reductase type 9 n=1 Tax=Escherichia coli RepID=DYR9_ECOLX  E=2e-34 s/c=0.90 id=32% cov=95%
-LNMIVAVNKTGGIGFENQIPWHEPEDLKHFKAVTMNSVLIMGRKTFASLPKVLPGRLHVVVSKTvppTQNTDQVVYVSTYQIAVRTASllvdkpEYSQIFVIGGKSAYENLAAYVDKLYLTRVQLNTQQDT---ELDLSlfkSWKLVSEV--PTITENKTKLIFQIW---
>UniRef50_P16184(7-204:206) Dihydrofolate reductase n=38 Tax=Pneumocystis RepID=DYR_PNECA   E=5e-34 s/c=0.73 id=34% cov=99%
-LTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFvptfdsfesmNVVLMGRKTWESIPlqfRPLKGRINVVITRNESLDlgNGIHSAKSLDHALELLYrtygsessvQINRIFVIGGAQLYKAAMDHpkLDRIMATIIYKDIHCDVFFPlKFRDKEWSSVWKKEkhsdleswvgtkvpHGKINEDGFDYEFEMWTR-
>UniRef50_C5VBQ6(1-156:160) Dihydrofolate reductase n=5 Tax=Corynebacterium RepID=C5VBQ6_9CORY   E=9e-34 s/c=0.92 id=41% cov=93%
MLRAIWAQNLMGLIGDGKSMPWHVPEDLQHFKKLTLGSPIIMGRRTWESLPvRPLPGRKNLVLSRRTpgKWSNGASVIASVPE---------SGWVIGGGVVYAATIDKVQEIHRTLIDAPtnlFElGDraVFAPTIPPD-FQLVQHSKWLKSS-SGLRYKFETWTK-
>UniRef50_A8RBH0(1-134:153) Putative uncharacterized protein n=1 Tax=Eubacterium dolichum DSM 3991 RepID=A8RBH0_9FIRM  E=9e-34 s/c=1.07 id=27% cov=84%
MIAMIVAVDKNGLIGNKNRLPWHCPEDLKHFYRTIKNHELLMGKRTFDSIR--LKDNVVHVVTHQTiKEQDNIRICTDLSAFLKQWQTSEKtLFVCGGASIYQQAFPFCSEAYVSVIDGEYQGDCYLPPMDFSLFQ-------------------------
>UniRef50_Q8SDF8(3-172:173) PHIKZ004 n=1 Tax=Pseudomonas phage phiKZ RepID=Q8SDF8_9CAUD   E=9e-32 s/c=0.81 id=34% cov=89%
-IKLIVAHDLNGVIGYNNLLPWHIPEDLAFFKEMTTGCCVIMGKNTFLSLGsKPLPNRNNIVVSSSLyrngnypvAYDNKLGVLPNLSAAIVYAthfnkETGKDVWIIGGSQLYKEVIekDILDEMYITTVKMEIDNSscVYFPKeiIKWDKWKSTIIKETD-----------------
>UniRef50_D2RA19(11-216:219) Dihydrofolate reductase n=1 Tax=Gardnerella vaginalis 409-05 RepID=D2RA19_GARVA  E=1e-31 s/c=0.67 id=36% cov=92%
-----------GAMGVNGGMPWRLSPDLRYFKAMTIGCPVIMGRGTWDATPpkfRPLPGRENIVVTHNPDFvADGARSFTSIDAALNYAREWLEnretlrsqgsvsqdasqdfpqdspqdgraIWVIGGAAILREMLAnyHADAAYVTQIDAKVAADTFAPNIhalvDAGKWHVAREGEFEEallkvgSESNPTRYRFMVYE--
>UniRef50_P90486(8-184:210) ORF 2 n=6 Tax=root RepID=P90486_HHV8   E=3e-30 s/c=0.75 id=29% cov=97%
----VVAVDTKLGIGKNRCLPWPaLRGDMRRFRQLTTDcapgkqNMVVMGRRTWLSIPagcRPLAGRINVVLSRTLETPPPGAHFlaSSLDAALglarspELAQQIDKVWVIGGGDLYREALtgPWPVRLFLTRVLHDFACDVFLSHDSLAAYARVNPKPGEQErvfQERGIFYMFETYIK-
>UniRef50_P22906(8-192:192) Dihydrofolate reductase n=7 Tax=Saccharomycetales RepID=DYR_CANAL   E=4e-30 s/c=0.71 id=32% cov=98%
---IVAALKPALGIGYKGKMPWRLRKEIRYFKDVTtrttkpnTRNAVIMGRKTWESIPqkfRPLPDRLNIILSRsyeNKIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNELINnsLVSHLLITEIEHpspeSIEMDTFL-KFPLESWTKQPKSELQKFvgdtvleddiKEGDFTYNYTLWTRK
>UniRef50_Q07422(5-251:610) Thymidylate synthase n=6 Tax=cellular organisms RepID=DRTS_TOXGO   E=5e-29 s/c=0.52 id=37% cov=100%
-VCLVVAMTPKRGIGINNGLPWpHLTTDFKHFSRVTKTtpeeasrlngwlprkfaktgdsglpspsvgkrfNAVVMGRKTWESMPrkfRPLVDRLNIVVSSSLKEEDiaaekpqaegqqRVRVCASLPAALSLLEEeykdsVDQIFVVGGAGLYEAALSLgvASHLYITRVAREFPCDVFFPAFPGDDilsnkstaaqaaapaesvFVpfcpELGREKdneatyrpifiSKTFSDNGVPYDFVVLEKR
>UniRef50_C5DEY6(8-221:237) KLTH0D10802p n=1 Tax=Lachancea thermotolerans CBS 6340 RepID=C5DEY6_LACTC  E=8e-29 s/c=0.59 id=32% cov=99%
IVTIVACLMPEMGIGYNGKLPWRLKQEMAYFRQVTsatfadgKRNAVIMGRKTWESIPpkfRPLPDRVNVVVSRQFAEDlapaqssapgsklsshagaaapasPALWLSNSLTRCLDLLpqrvPDLERIYVIGGAEIYAQSNSLCDYMLITKIEPEsaterPPMDAFldtqsihalfqhdqsLPSFLPPA---VSLPADPYISENGYRYNFALYRRR
>UniRef50_Q54LA0(3-190:204) Dihydrofolate reductase n=1 Tax=Dictyostelium discoideum RepID=Q54LA0_DICDI  E=1e-28 s/c=0.68 id=34% cov=99%
-VSIIVAVSKNNVIGtKAGDIPWELPKDLKHFRDTTHGFPCIIGRISLEAFGDLLPNRFNIIVSSKkefinirekiainlPEYETGITekgaqyvIVKSVKEAVDYAKDILKtdlVYICGGKGIYEDSQQYSHELIITDVDVHIeENDVViynpFPSNDErNKWKVVNQIHHPKDHQNNLDFSITYYVK-
>UniRef50_Q256K1(7-155:162) Dihydrofolate reductase n=13 Tax=Chlamydiaceae RepID=Q256K1_CHLFF   E=1e-28 s/c=0.85 id=31% cov=92%
----IVACSPSGVIGNQGKLPWSYSKDIEFFAKTIENKPLVMGRKTWEGLPEKYtKGRQIFVFSRSFyDNAEGVIWVSSLEEFFSL-ELPPSVFLIGGGDLFSLFLEnqLLTGCFVTHIHRCYDGDAFFPLSLLVGWNKTI-----LDEQEDL--TFCYYE--
>UniRef50_Q76YB8(1-151:172) Frd dihydrofolate reductase n=1 Tax=Aeromonas phage Aeh1 RepID=Q76YB8_9CAUD  E=1e-21 s/c=0.69 id=26% cov=87%
MIKAVFATGKFGEFGNKNGLPWgHCRVDMLNFMETTKDSCLLMGAKTFMSLPTKLKNRVNVVLSTSNDTNrvvakngerPDMFMHGDVTQALSELQTlYNNICVIGGMTVLKEAIDMADQVVHTVIlnEEKLECDV---ELDETVQEKITSDFY------------------
>UniRef50_Q5D6W5(6-130:159) Dihydrofolate reductase type IIIb n=3 Tax=Enterobacteriaceae RepID=Q5D6W5_ECOLX  E=2e-21 s/c=0.82 id=25% cov=77%
----IFAVAENLAFGLGGGLPWDtLKDDLQFFKRLTEGTDLVMGASTYRTLPlLPTNNRQFIVVSNTEEPSLNVHVVSPEHFKAFLSKTSRNLTIIGGSSLLTvDILSKMDKIIMTTVYGSFDADVYLP---------------------------------
>UniRef50_C5FNI6(8-246:275) Dihydrofolate reductase n=1 Tax=Microsporum canis CBS 113480 RepID=C5FNI6_NANOT  E=2e-18 s/c=0.39 id=30% cov=87%
-LTLVVATTpittaanpsiRKLGIGKGGTLPWpKIKTDMRFFARVTTRpppstnasgapviNAVIMGRKTYDSIParfRPLSKRLNVIITRDESgsvmeraiadwnafknrelekgdnstaastEEPDVMVSNSLEAALSTLQSSFasssssevgagkrrlgNIYIMGGSEIYASSLRLTPsvlgennplRIIMTHVRRRgdadtqsdveslvngFDCDTCFP-IDQqgmkEGWKEVSSEE-------------------
>UniRef50_UPI0001BC45D8(8-160:169) dihydrofolate reductase n=3 Tax=Fusobacterium RepID=UPI0001BC45D8   E=6e-18 s/c=0.60 id=23% cov=89%
-LKMIVCVGENNLIGdkvpSGNGLLWHSKEELLYYKSITTGQVTLFGENTAKFVPVDLMKktREVLVLTMDSN----------IDEILKQYPE-KDVFLCGGATIYQYYLEHypIAQVYLSKLKAHVAvGEAknplYFPNLEKLGYEVVKETEYE-------DFIAYIYEKR
>UniRef50_Q8KQF2(3-130:163) Dihydrofolate reductase n=2 Tax=Methylobacterium extorquens RepID=Q8KQF2_METEX  E=7e-18 s/c=0.72 id=25% cov=77%
---LIAAIGRRGQLGLEGDMPWgrSFPDDLRRFRELTAGGIVLVGWRTWPTVERLqgTHGRRFVV--DDVKLPPTGMLVR-LQEPDASGTRDRPVWIAGGAKTYARYARFVDEFVVRRVPYDGPADTWMPDL-------------------------------
>UniRef50_Q56EF6(1-147:184) Frd dihydrofolate reductase n=3 Tax=unclassified T4-like viruses RepID=Q56EF6_9CAUD  E=7e-17 s/c=0.60 id=24% cov=81%
MIKAVFALGVpsdfhmNGmfAFGKDNDLPWeKIPKDFTLFREKTMGCICVMGAKTFQSLPFNLPGRVMVVIGdinrscRNKSGELPALHVnindHDWMSTVESLYPDQDIAIIGGLGMIINNLHLCDEIHINFLMLTAEYDTINPSI-------------------------------
>UniRef50_C5PHX7(27-310:310) Dihydrofolate reductase family protein n=3 Tax=Onygenales RepID=C5PHX7_COCP7  E=9e-17 s/c=0.31 id=30% cov=100%
-LTLVVATTPvtshtnpsisRLGIGNCGTLPWpRIKSDMSFFARITTRppaaaqpqlhtpnalNAVIMGRKTYDSLPsrfRPLPKRLNVIITRDESgmvceraaaewkaarkrewekaqekkdefrteskscsstekndsieelekETPDVLVSNGIGSALLALRDSfnpfsqngrrslGNVLVIGGAEIYASSLKLDPtglgckmRIVMTDVRRPtseaekndpsrssngFECDTFFPidNLDgNDEWRrasagEVSEWVGEAVPEGwvwdqDIALRFLGYERR
>UniRef50_C5CHN8(3-125:179) FolA n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=C5CHN8_KOSOT   E=5e-16 s/c=0.70 id=34% cov=71%
-ISIVAVNSVNGLISRDSdyDVDWSSPDDRKFFKKITTSaGVVIFGRRTFETIGKPLPKRLNVILTRTPekfhSTENLLFTNDEPEILISKIGrlGFKHIVIGGGREIYTLFLknKLVTDIYLS----------------------------------------------
>UniRef50_A9BEP7(3-139:176) Dihydrofolate reductase region n=1 Tax=Petrotoga mobilis SJ95 RepID=A9BEP7_PETMO  E=5e-14 s/c=0.58 id=28% cov=77%
-VKLIMVQSINGKIrmSDDSQRSWSSAEDKEHFYNITKDiGIILMGRKTFEEIGSPLKNRINIVLTGNPEKYKEVELKYDkylyftdnpPEILLDKLekKGYPEVALIGGSTINSLFLEknLIDEIFLTIEPVIIEGD-------------------------------------
>UniRef50_C0QKC0(3-130:167) FolA n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QKC0_DESAH   E=9e-14 s/c=0.61 id=27% cov=72%
-VILVMAMTLDGKIARDsnHSADWTGKDDKKKFVEITKRaGAMIMGSKTFDTIGRALPGRKNIVMTRNRSrkSDGNLIFTDQPPDLILKGLDREgfsEVALIGGTQINSLFaqANLIDEIFVTVV--------------------------------------------
>UniRef50_B8QTX4(1-152:186) Putative dihydrofolate reductase n=1 Tax=Erwinia phage phiEa21-4 RepID=B8QTX4_9CAUD  E=1e-12 s/c=0.49 id=28% cov=77%
MITTIYAVNSVGAFGnRDGSLPWpKNSEDLQRFAFLTKNiGTVLMGKSTYNSlaarhpnqldIHLPLKERNAIVLTTKLpcgqpiefgemvsykvDGKDVHFLHHETHMAVKLAERfYNSVAVIGGAGIIGESLAISNEVYVTVLDSDEQAD-------------------------------------
>UniRef50_Q7M0N6(1-49:49) Dihydrofolate reductase, type IV (Fragment) n=2 Tax=Enterobacteriaceae RepID=Q7M0N6_ECOLX  E=1e-10 s/c=1.38 id=40% cov=31%
MIRMILAINNQYFIGKNNTLMYRLKDDMLNFKKMTQNNIVVMGRKTFES--------------------------------------------------------------------------------------------------------------
>UniRef50_UPI000050F9FB(16-138:187) bifunctional deaminase-reductase domain protein n=1 Tax=Brevibacterium linens BL2 RepID=UPI000050F9FB  E=1e-07 s/c=0.47 id=34% cov=39%
--------------------------------------AVMMGRKTYEAIasiqEWPYLGRPIHVISTtlDADADPRIIVHRSPEAAIDAAElsGCKRVYVDGGATV------------------------------------------------------------
>UniRef50_Q2WAT9(10-122:173) Dihydrofolate reductase n=2 Tax=Magnetospirillum RepID=Q2WAT9_MAGSA   E=5e-07 s/c=0.49 id=27% cov=60%
------AASLDGYIAdSDGSIAW-----LKPFDAIDYGfdefmehiGTVVMGRTTYEHLhamgHWPHGDKRCIVVTSRSmeTAPDNVEpWLGDLAQLVAELKASPdgDIWVAGGAKALRAFLDL-----------------------------------------------------
>UniRef50_C6VJR8(9-175:179) Reductase (Putative) n=3 Tax=Lactobacillus plantarum RepID=C6VJR8_LACPJ  E=2e-06 s/c=0.32 id=29% cov=86%
------AISIDGCLAtKDNRLDW-------LFKTAGANDApteafmqqvdtAIMGRHTYEYMMEqttdqlinPYnPATHNIVMTSHPHTGDertqftNTPVTKIVEDLRRTAG--KNIWIVGGAGVLMPLLaaDLVDELYI-QIAPVILGDgiPLFKAIDQQQrFELVDTNRYGQLAE-------VHYQR-
>UniRef50_Q2H6E6(14-120:218) Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2H6E6_CHAGB  E=6e-06 s/c=0.49 id=44% cov=35%
-LTLIVAATQQMGIGRNGALPWTgLRREMAYFARVTKRvpstttttttttptttttppptvstptptptptttqgttqpqhqpqpqteiqNAVVMGRRTWESIPPSLP--------------------------------------------------------------------------------------------------------
>UniRef50_B2J4J8(4-136:177) Bifunctional deaminase-reductase domain protein n=1 Tax=Nostoc punctiforme PCC 73102 RepID=B2J4J8_NOSP7  E=9e-06 s/c=0.39 id=28% cov=64%
-VTLYIAASLDGYIARsDGGIDW-LSildiegEDYGYgtFYESI--DAIVLGSNTYEvGLGfdeWPYPGKKSFVFTKrhlQSDREDVVFVSDTVKNALAniEAQGFENIWLVGGGALINSFL-------------------------------------------------------
>UniRef50_Q8NSF5(1-145:189) Dihydrofolate reductase n=3 Tax=Corynebacterium glutamicum RepID=Q8NSF5_CORGL  E=1e-05 s/c=0.35 id=21% cov=70%
MMAIIYntSSTLNGFIAdKDNSLQWLFdvpgsdgaSEDFGNF--LSKAGTIVMGSTTYEWLLKDLDfisdphkwtdvygDRPTWVFsSRNLETPEGkpvkvvnGDVADVLPAILEESPENTDIWIVGGGDLAGQFFDagALDRIILT----------------------------------------------
>UniRef50_UPI0001B44834(42-80:81) dihydrofolate reductase n=1 Tax=Listeria monocytogenes FSL J2-003 RepID=UPI0001B44834  E=2e-05 s/c=1.28 id=41% cov=25%
---------------------------------------LVMGRKTYESLGKALPNRKTIVLTRDQGLKlDDAEILHS----------------------------------------------------------------------------------
>UniRef50_C9ACK3(9-129:177) Putative uncharacterized protein n=3 Tax=Enterococcus casseliflavus RepID=C9ACK3_ENTCA  E=3e-05 s/c=0.41 id=23% cov=57%
------AISLDGYLaGLKDQLDWLFQTDTgvattyeAFFATI---DATVMGRKTYQeakklmDGGLLYPETTNYVFSRTQKEplPDATLVSTDPVAFVSALKQEENVWVVGGGSL------------------------------------------------------------
>UniRef50_B2I4E4(1-62:136) Putative dihydrofolate reductase n=1 Tax=Enterobacteria phage EPS7 RepID=B2I4E4_9CAUD  E=9e-05 s/c=0.78 id=25% cov=37%
MIAAIYATGPNGEFGLNGKLPWgSFKEELDIFYATLDSlapDNIIVGAGTWLAFPETLQKRI-----------------------------------------------------------------------------------------------------
>UniRef50_A7HGT6(8-135:182) Bifunctional deaminase-reductase domain protein n=2 Tax=Cystobacterineae RepID=A7HGT6_ANADF  E=0.0001 s/c=0.37 id=21% cov=68%
-----VAASLDGYIAdADGRLDWLFQFDDAegvkahHERFMSEVGALVMGARTYDFIleqggAWPYAGLPAWVFThRERPAPPGADVrftsedVRAVHASMVKAARGRNVWMIGGGELAAQFLAHglLDELHL-----------------------------------------------
>UniRef50_B0QTU6(15-51:51) Dihydrofolate reductase n=1 Tax=Haemophilus parasuis 29755 RepID=B0QTU6_HAEPR  E=0.0001 s/c=1.29 id=46% cov=23%
----------------------------------------------------------------------------------------NEIMTIGGGKLLKQAIPLTNTLYLTEIQTRIDGDTF-----------------------------------
>UniRef50_P45862(10-135:174) Uncharacterized protein ywjB n=1 Tax=Bacillus subtilis RepID=YWJB_BACSU  E=0.0001 s/c=0.38 id=20% cov=68%
------AVSLDGMIAKeDGSIDWldefEGEGDNGYsdFYQTV--DTVILGRSTYEHVKvltpvFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAftarlKQEKGSNIWIAGGAELVNDFMkeDAIDEFIITVI--------------------------------------------
>UniRef50_A5V5J4(9-141:186) Bifunctional deaminase-reductase domain protein n=2 Tax=Alphaproteobacteria RepID=A5V5J4_SPHWW  E=0.0002 s/c=0.35 id=27% cov=50%
--------------------------DYARFLQRI--RTVVMGRGTYdfiaaEDVPWAYGDQRVLVVTSRPIPAPKgpLETRSDVDALIAELRslDDGDVWMLGGGQLQMAFLER-----------------------------------------------------
>UniRef50_Q12WB0(10-130:174) Dihydrofolate reductase n=1 Tax=Methanococcoides burtonii DSM 6242 RepID=Q12WB0_METBU  E=0.0002 s/c=0.39 id=26% cov=65%
------AMSLDGYIAtKSGSVDWliDIPGyDFyDRFIENI--GVVVMGRKSYEmilsfDVEWPYKFARSYVLTHGNKFEDTDLVkftnisVKGLVEELS-SETEKDIWVLGGGEVVREFLDskLIDEIII-----------------------------------------------
>UniRef50_B8FSZ4(8-118:181) Bifunctional deaminase-reductase domain protein n=2 Tax=Desulfitobacterium hafniense RepID=B8FSZ4_DESHD  E=0.0002 s/c=0.42 id=28% cov=42%
--------------------------------------TLLMGRRTYEIVratGESFRGKQVIVASRslRPVDHPDVEIVSeGLEARVRELRGQPgrDIWLYGGGNLFSQLL-------------------------------------------------------
>UniRef50_C3ZNF8(8-136:186) Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3ZNF8_BRAFL  E=0.0006 s/c=0.35 id=27% cov=63%
-IRIMSAMSVDGYIStQDGGVAW-----LDQFNDVDTGyddflkqiETVVMGRTTYEQVrgfdcPWPYATKKAVILTTKNLTDLPTEqttcysgNVRDLADNLLKTTTTGDIWLVGGRMVTQAFLD------------------------------------------------------
>UniRef50_D0U4K0(21-178:179) Dihydrofolate reductase n=2 Tax=uncultured SUP05 cluster bacterium RepID=D0U4K0_9GAMM  E=4e-56 s/c=1.38 id=46% cov=99%
-LSIIVAMDDNQLIGKNNALPWHLPADLGYFKKVTTGKTVLMGRKTYESIGRPLPNRRNVIVSRNTNFKaDGCEVVSSIDAALKLAKDDSEVMVMGGASFYEQMLPSVDRLYITQIEGEYQGDAHFPKFDRGKFSEVSRESHTADEKNQYTYHFTILDR-
>UniRef50_Q1LK80(3-160:166) Dihydrofolate reductase n=3 Tax=Proteobacteria RepID=Q1LK80_RALME   E=6e-55 s/c=1.36 id=42% cov=99%
LLTLIVARARNGVIGRNNTLPWRLPEDLQHFKRTTMGAPIIMGRKTWDSIGRPLPGRRNIVVTRNRDLHiEGADVVGSIEDAQRLCIGAEQVFLIGGAQLYAEALPSADRLIVTEIDADVEGDAFFPAVDRTTWVETARELHH-SETNGFDYAFVTYER-
>UniRef50_D0KZ69(3-161:177) Dihydrofolate reductase n=2 Tax=Gammaproteobacteria RepID=D0KZ69_HALNC  E=4e-54 s/c=1.33 id=52% cov=99%
-IGLVAALTRNQVIGRYNALPWSLPADLQRFKKITMGKPIIMGRKTYDSIGRPLPGRKNIVISRNPDFHaDGVTVVDSLDMALEAADQAPEVMVIGGANIYYQFLPRADRLYFTLVHTTIdDGDAFFPAYNRRDWRLVIEENHPADADNPFPYSFMTWQR-
>UniRef50_A9KH09(2-160:161) Dihydrofolate reductase n=8 Tax=Coxiella burnetii RepID=A9KH09_COXBN  E=1e-53 s/c=1.32 id=42% cov=100%
IITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSIGKPLPHRRNIVITQQKNLiIEGCDIFYSLDDALSALTKEPEVIIIGGARIFKEALPKADKMILTIINHSFEGDVYFPEWNDKEWKITSQIKHERDEKNPYPFQFLELRR-
>UniRef50_A9I779(21-177:178) FolA protein n=2 Tax=Bordetella RepID=A9I779_BORPD   E=2e-53 s/c=1.33 id=44% cov=99%
-LTLVVAYSDNRVIGRDNTLPWKLPGDLAHFKRTTLGSPIIMGRKTWESLGRPLPGRTNVVISRNLRYaAPGATVVPTLQAAVEACGDAPDAYVIGGAQIYAQALPLAARVIATEVHAHVEGDAFFPYLPSFAWREASRQPQPA--ENGYDYDFVVYERQ
>UniRef50_A0AJX9(1-159:160) DfrA protein n=15 Tax=Listeria RepID=A0AJX9_LISW6   E=1e-52 s/c=1.30 id=38% cov=100%
MIIFVWAQDRAGNIGKDNTMPWHLPGDLQFFKKTTTGKTLVMGRKTYESLGKALPNRKTIVLTRDKELQlDDAEILHSREEVLALTQTGEPIYVVGGAEIYRLFMDVADKLIVTKIDAEFDADTAFPEVDWENFSEIAKEPHEKDEKNKYNYTFYTYER-
>UniRef50_Q2Y7L3(5-171:183) Dihydrofolate reductase n=7 Tax=Betaproteobacteria RepID=Q2Y7L3_NITMU  E=2e-52 s/c=1.23 id=45% cov=98%
-LSVLVAMARNRAIGHKNAIPWHLPHDLKHFKELTMGHPMIMGRKTYESIGRLLPGRTSIIITRQPDYEvPGALVVSSIGEALSACKQIrsgeeghpdqgNECFVIGGADIFQQMLPLCDRLYMTEIHRDFEGDTYFPEFDRNDWWEVSREEHVDDS--GLEYHFVTLDR-
>UniRef50_Q31I54(14-173:175) Dihydrofolate reductase n=32 Tax=Bacteria RepID=Q31I54_THICR   E=4e-52 s/c=1.28 id=46% cov=100%
-ISMIAAMDKHRIIGADNDMPWHLPDDLKFFKANTVNKPVIMGRKTFESIGsKPLPNRRNLVITRNDAYEaNGAEVFHSAEEALKSCKSEVEIIIMGGGQLYAQMMPFANKLYVTLVDAEVAGDTTFPEWLTDEWQEISKEWHDKDERHAYAFEFVTLIRK
>UniRef50_Q0VM07(7-171:171) Dihydrofolate reductase n=5 Tax=Gammaproteobacteria RepID=Q0VM07_ALCBS  E=7e-52 s/c=1.24 id=44% cov=100%
-LSMMVAKATNNVIGRNNKLPWYLPNDLKYFKQVTFGKPVIMGRKTWESLKGPLPGRTNIVITRQPAYQaEGAKVVATVDDAITMAENVafiegqEEAVIMGGAEIYALALAQTQRLYLTEVHAEVDGDTFFPEYDKGEWEEIAREDFPAEGPNPYDYSFVVYERK
>UniRef50_A1AXR7(3-160:163) Dihydrofolate reductase n=6 Tax=Proteobacteria RepID=A1AXR7_RUTMC   E=2e-51 s/c=1.28 id=39% cov=99%
-LSIIVAMDDNQLIGKNNALPWYLPADLAYFKKTTIGKAVLMGRKTYDSIGRPLSNRRNIIVSRNTKLKvDGCEVVGSINVALNLVNGANELMIMGGVSFYEQMIDKVDRIYITEVNGKFDGDTYFPEFDRTKFSELSRESHQPDEKNLHAHNFVILQK-
>UniRef50_Q1QUE0(19-184:195) Dihydrofolate reductase n=12 Tax=Bacteria RepID=Q1QUE0_CHRSD   E=3e-51 s/c=1.22 id=42% cov=99%
-IALVAAMSRNRVIGVDNKLPWHLPEDLKFFKAVTMSKPLVMGRKTFESIGRPLPGRLNIVVTRDRGYaqdHDGIRVCHDLASALDMAdgqaiiDGVEDICVIGGGEIFAEALPCATRLYLTEVDIEVEGDAWFPAFDAREWQETQRVPGQGGEGKP-EYAFVHYTRR
>UniRef50_Q47IJ5(4-163:163) Dihydrofolate reductase n=2 Tax=Bacteria RepID=Q47IJ5_DECAR   E=6e-50 s/c=1.24 id=37% cov=99%
-IILIAAVAKNRVIGKDNTLIWNLPEDMAHFKALTAGQTVVMGRKTWESLPprfRPLPGRRNVVISRQADYaAPGAEVANSLENALQLASTAESVFIIGGEQIYKQAMAVADRLEITDVDLEPAGDAWFPEIAATDWSVTQKNTPP--SQSGTGFSFVTYRRK
>UniRef50_A5CVJ7(3-160:163) Dihydrofolate reductase n=1 Tax=Candidatus Vesicomyosocius okutanii HA RepID=A5CVJ7_VESOH  E=2e-49 s/c=1.24 id=38% cov=99%
-LSIIVAMDDNYLIGKDNSLPWYLPADLAYFKKITIGKTILMGRKTHDSIGRSLPNRRNIIVSKNTKFKaDNCEVVSSIDVALSLANNDNELMIVGGSSFYDQIIDKVDRLYITEVKGMFDGDAYFPEFDRTKFIELSRESHKPDEKNFYTYNFIVLQR-
>UniRef50_A3N0P3(3-162:162) Dihydrofolate reductase n=6 Tax=Pasteurellaceae RepID=A3N0P3_ACTP2   E=3e-49 s/c=1.23 id=50% cov=99%
-ISLIVARTLNHVIGKENQMPWNLPVDLAWFRQNTLGKPVIMGRKTYESIGRLLPKRPNIILSRSGFCVEGAYTAQNFAQAAELAEtfaNTDEIMVIGGGELFKQTIPQADRLYLTEIQAEIEGDTLF-EFDESNWTLVEEKWSEIDEQNAYRCRFMILERK
>UniRef50_Q54277(7-164:166) Dihydrofolate reductase n=84 Tax=Bacilli RepID=DYR_STAHA   E=4e-49 s/c=1.23 id=39% cov=99%
-ISLIVAMDKKRVIGKDNDIPWRISSDWEYVKNTTKGHAIILGRKNLQSIGRALPDRRNIILTRDKNFNfKDCEIAHSIEAAFKLCENEEEVFIFGGEQIYVMFLPYVEKMYVTKIHHEFEGDTFFPVVNFDDWKEVSVEKGIKDEKNPYDYYFHIYER-
>UniRef50_Q2K6G9(7-170:172) Dihydrofolate reductase protein n=3 Tax=Rhizobiales RepID=Q2K6G9_RHIEC  E=7e-49 s/c=1.18 id=41% cov=99%
--TIIAAVARNGTIGREGDMPWRLSSDLKRFKTLTLGKPVVMGRRTYDSIGKPLPGRPNVVISRQAAIDhSDISMAHSLAEALEAAErlalqtGAGEICIIGGGQIYAQAIDLADRMYITHVEADLDGDAFFPAIDPGTWQAGEVVAVPAGERDSYPTRFVVYERR
>UniRef50_C3JBM5(3-161:170) Dihydrofolate reductase n=2 Tax=Bacteria RepID=C3JBM5_9PORP   E=2e-48 s/c=1.21 id=32% cov=99%
-LSIIVAVAANNAIGKDNDLLWHLPGDLKRFKETTTGHAIIMGKNTFHSLPnGALPNRRNIVVSSTLVPPDGVECYSTLQAALEAVAGEEEVFIIGGAQLYAASLPLADKIYFSRVEKGFpEADTYFPEFDLTEWTPSYCTLYPEDERNEYAVTLTIYQR-
>UniRef50_A1TM51(3-165:165) Dihydrofolate reductase n=4 Tax=cellular organisms RepID=A1TM51_ACIAC  E=3e-46 s/c=1.14 id=38% cov=99%
-LRLIYARAANGGIGLHNAMPWHLPEDLAHFKQLTLGATVVMGRKTWDSLParfRPLPGRTNIVVTRQAGWHaDGALSASSLEQAVELARPHgDTVWVMGGAQIYAQALPMADGVEVTEIHRDFEADAFAPVLGP-EWEETARTPVQTSAGSaALPFSFVSYRRR
>UniRef50_Q6MID1(2-169:169) FolA protein n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MID1_BDEBA   E=5e-45 s/c=1.08 id=33% cov=98%
ILTHVVACSQNRVIGAQGGLPWSLPEDMKFFRETTKGHIMIMGRKTFDSFnGRALPNRYHIVVTRDPskqsfnsTESSPVVFVASIEEAVKHAEPltakwGDEVFIIGGGEIYKQAMPITDKIYLTLIHREFPGDTYYPEIDEKVFTQTER----RDIETPIPFSFLTYLRK
>UniRef50_B6BUF2(1-147:148) Dihydrofolate reductase n=1 Tax=beta proteobacterium KB13 RepID=B6BUF2_9PROT  E=3e-44 s/c=1.22 id=31% cov=92%
-------MSENNVIGIDNSLPWHLSGDLKRFKAITTGHQIVMGRKTYESIGKPLPNRVNFVLTRNSDLKiDGVHVISSLND---ISDSDKKTFIIGGGEIYSQLIDSCDELLVTKIHREIHGDAFFPMIDASVWSLVDQ--SEKLNENDIEFSYLTYRK-
>UniRef50_D1PCZ0(1-178:179) Dihydrofolate reductase n=1 Tax=Prevotella copri DSM 18205 RepID=D1PCZ0_9BACT  E=6e-43 s/c=0.98 id=38% cov=99%
MLSIIACISKvHRAIGYKNRLLYAIPSDMTRFRMLTTGHTIIMGRKTFESLPnGALPNRRNIVISKTREQITGCEVYTSLEEALAARKEEaarkeevgnketvgskeasDECFIIGGASIYEQALPFADKLYLTIVEKEPEhADTFFPEINPAEWEVTEKEMRN---ENGLPFTFLTLYRK
>UniRef50_Q93341(4-184:189) Putative dihydrofolate reductase n=2 Tax=Caenorhabditis RepID=DYR_CAEEL  E=9e-39 s/c=0.89 id=32% cov=99%
-MNLIVAMDAEGGIGKNGVLPWRIKKDMQYFASVTKNvsdqskrNAVLMGRKCWESIPvtrRPLAGRLNIVLSRQlpAQKSDDYIVVNSLEAAMKLLSEppfvdsIETIWNIGGAEIYDLALreNLVDEIHLTRIFKNFEADVHLKSLDFSKMEkvqnaEVSSENSEIFEENGLKFEFCKWK--
>UniRef50_C4WVU0(7-183:184) ACYPI002804 protein n=1 Tax=Acyrthosiphon pisum RepID=C4WVU0_ACYPI   E=1e-38 s/c=0.90 id=32% cov=99%
--SVIAAVSKNGGIGYKGNLPWKIKKEMEYFNLMTTrvnlkgvQNAVIMGRCTWQSIPdkyRPLKGRINVVISKTLNSvPEGVLLYPKLEEALKSLylnDRIENLWVIGGSGLYKEAVNdkNCKKLFITKIDQEYLCDTFFPDFDTKKFEETSEANVPKgiQEDNGIKYEFKVFKR-
>UniRef50_C4QMV9(3-179:186) Dihydrofolate reductase n=1 Tax=Schistosoma mansoni RepID=C4QMV9_SCHMA  E=4e-37 s/c=0.88 id=34% cov=99%
-LNVVVAVSENWGIGKGGGLPWKIKKDMEFFKTVTTkahpglKNAVVMGRVTWESIPesfKPLKDRINIVVSSTLSHAPSfVQVVPSLNAAIDLLYNEEfssivdEVFIIGGYRLYKEALKqsiYPVRIYCTHILSEVDCDTYFPKVDWDKLKKVDLPDIPADtfTENGFTFKFCVYD--
>UniRef50_C5RC79(8-168:168) Dihydrofolate reductase n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5RC79_WEIPA  E=6e-36 s/c=0.94 id=32% cov=99%
---LIWAQTLDGTIAIDGHIPWHQKADLQFFKQSTIHEAALMGRHTMASFhGRPLPERLNLVLTRNHDLEvpEGFQKVYSVAEAEKVADNANlKLQVIGGKPIYESFMDTADTLYVTYLQTDFSGDVKMAPVDLTVWQGEVIDQGPADADNDYDWRLVKYTRQ
>UniRef50_A9HP20(1-137:154) Dihydrofolate reductase n=1 Tax=Roseobacter litoralis Och 149 RepID=A9HP20_9RHOB  E=8e-36 s/c=1.10 id=38% cov=81%
------ARAENGAIGRDGTIPWNVPEDLKFFQRETLGGALIMGRNTWESLPvKPLPRRFNVVVSSNSDTAE--VVAPSVKVAIELAieHGHQRIYGIGGAAIYQEMLPLAHRLLISEVQIDVpDADTFFPNFDVAGWKAI-----------------------
>UniRef50_Q4JX60(42-234:234) FolA protein n=3 Tax=Corynebacterium RepID=Q4JX60_CORJK   E=2e-35 s/c=0.77 id=36% cov=99%
-IGMIWAQTTDGVIGDGADMPWYLPEDLKHFKNATSGYPVVMGRTSWEALDdgfRPLPDRTNYVITRQDNYDaPGGIVEPSIPSALANAAEqilneltdsadkgegaddrTPTVWVLGGGQVYAQCMPVADRIVITEIDMEaperFQ--VYAPLVPEEEFEESAQDwqesekghpvDQEVDTEQPLRYRFCTWTRR
>UniRef50_Q6CC38(6-189:189) YALI0C12771p n=1 Tax=Yarrowia lipolytica RepID=Q6CC38_YARLI   E=2e-34 s/c=0.79 id=36% cov=99%
--TLILAATvPRYGIGLNGGLPWRLAKEMKFFKQVTTaqkNAVVIMGRTTWDSIPpkfRPLPDRTNIVLTSRPmtDAPEEVVVARSFDEALTKCPEDSTVYVIGGSQVYKTALvhEHTKAVLLTEItcpDGHVECDTFFEGFDQGLWKKQPYERLQdfvgdkvelpgrdtPVEEKGFSFVYTLWEK-
>UniRef50_Q8EV82(1-153:154) Dihyrofolate reductase n=1 Tax=Mycoplasma penetrans RepID=Q8EV82_MYCPE  E=2e-33 s/c=0.93 id=30% cov=95%
MFISIWCEDKNRGIGKNNKLPWNIKEDLNLFKKHTLNNTIVMGKNTFLSIGKALPNRKNIVISKTLDASlyKDIEVYDDIEQFYNEYKNRDEsIFIIGGKSIYDYFINKCSILYVSKLNSAYECDLFMDN-SFDGFEIVNQKEYEQ-------FTFFEYRK-
>UniRef50_Q47FU1(7-168:185) Dihydrofolate reductase region n=1 Tax=Dechloromonas aromatica RCB RepID=Q47FU1_DECAR  E=3e-32 s/c=0.86 id=27% cov=98%
LISAIGAVASNGMLGLAGWLPWDIPEELAYFEKTVAGAALVIGRLTYESM--DVVPEDSFVVSRQADLvvRPGCSRVASVEEGLhRALATGKPVFVIGGASVYAAAWRYCHRFYLTRIERAFDGDSRFPEsVQLSDWKvesETVRQLREYKSNTDVTCRFLIYQ--
>UniRef50_B1ZSC9(6-163:164) Dihydrofolate reductase region n=1 Tax=Opitutus terrae PB90-1 RepID=B1ZSC9_OPITP  E=1e-30 s/c=0.85 id=34% cov=96%
----IVACSENRVIGRAGRLPWRIPEDWSFFRQRTARSTVVLGRISFQSWRSVLEDeRRAVVLTRNTSLAgDRVEVAHSLtAGLAAAGAHGREIYVCGGQRVFAEaiALPSATRLYLTLIHAHVDGDRTFPEW-RHEFPRVLEQREGGDEN--YRYTFFTLAR-
>UniRef50_Q9PR30(1-151:156) Dihydrofolate reductase n=28 Tax=Ureaplasma RepID=DYR_UREPA   E=4e-30 s/c=0.87 id=25% cov=94%
MLKLIWCQTLNGGISKNNKLPWYIKEELDHFYKTTKNHKIIMGKNTFDSLDqKPLNNRTNIIFSSIMQTPEDesYFVTNDFQQVLNDAKK-EDIFIIGGKELFDIFLAYADVLIVSVLKDYYDCDLYM-KVDYNNFNLDKQDVYDNFIVNYYS---------
>UniRef50_Q07801(12-225:229) Dihydrofolate reductase n=2 Tax=Filobasidiella neoformans RepID=DYR_CRYNE  E=5e-30 s/c=0.62 id=33% cov=98%
-ITAVVAATAENGIGLNGGLPWRLPGEMKYFARVTTGetpssdpseqNVVIMGRKTWESIPsrfRPLKNRRNVVISGkgvDLGTAENSTVYTDIPSALSALrsttesGHSPRIFLIGGATLYTSSLlpssvpslnsststsplpfsrPLIDRILLTRILSPFECDAYLEDFaahtkpdGSKVWKKASIKEFrewigwdieEQVEEKGVKYIFEMW---
>UniRef50_C5DXQ4(5-153:205) ZYRO0F06930p n=1 Tax=Zygosaccharomyces rouxii RepID=C5DXQ4_ZYGRO   E=6e-28 s/c=0.84 id=36% cov=74%
IVCIVAALCPHMGIGYRGGLPWKLSQEMKYFRQVTTstftegkSNAVIMGRRTWESIPakfRPLKGRINVVLSRQfpsFQREDDRFLSNDLSHAIKSLQDlpVERIYIIGGAQLYTESIDIATHWLVTNIH-------------------------------------------
>UniRef50_Q6BTR6(15-205:206) DEHA2C16456p n=2 Tax=Debaryomyces hansenii RepID=Q6BTR6_DEBHA   E=5e-27 s/c=0.64 id=36% cov=98%
---IVAALLPELGIGIKGKMPWRLRQEIKYFKNVTTttkdpngINAVIMGRKTWESIPtkfRPLPGRLNIVLSRSyvshGSNDEDIILTNSIENALAKVEEyskpVEKIFVIGGSELYNKLISHekVQHLLITEIKSTrpVEVDTWlkFPIYtessdwtkqtndDLSKFTGIDNEDVEITE-GDFTYKYTYWKKK
>UniRef50_P07807(8-211:211) Dihydrofolate reductase n=5 Tax=Saccharomyces cerevisiae RepID=DYR_YEAST  E=5e-27 s/c=0.60 id=33% cov=99%
IVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTsltkdpnKKNALIMGRKTWESIPpkfRPLPNRMNVIISRSFkddfvhDKERSIVQSNSLANAIMNLESNfkehlERIYVIGGGEVYSQIFSITDHWLITKInpldkNATPAMDTF---LDAKKLEEVFSEQDPAQlkeflppkvelpetdcdqryslEEKGYCFEFTLYNRK
>UniRef50_A8QGA9(7-164:172) Dihydrofolate reductase family protein n=2 Tax=Brugia malayi RepID=A8QGA9_BRUMA  E=1e-26 s/c=0.76 id=33% cov=91%
-MNLIVAVDGCGGIGRNGGMPWFLPAEMARFAKLTTltmdsgkKNAVIMGRKVWESIPpkfRPLKNRFNVVLSRkiKEESNENVVVARSFESAISLLQDmenIETIWNIGGRE-----------MYITRVEGDFLADVFFPEVDYGRFIK-STESEEMHEEKGIKYRYEIY---
>UniRef50_Q6CRP4(11-229:232) KLLA0D07458p n=1 Tax=Kluyveromyces lactis RepID=Q6CRP4_KLULA   E=4e-24 s/c=0.51 id=33% cov=96%
----VACLMPGYGIGYQGSLPWRLSKEMKYFRQLTsatrdssMRNAVVMGRKTWESIPakfRPLPNRLNVVVSRNCQLDINDEqtqftksrvgddddddggddatlyagdLSRAIDQLIANSKilGLETIYIIGGGDIYRQCIPMSHNLFITKIvpdlgMPVPPMDTF---LDREQIESQFKEqpHHKLQEivpkevslpqfsadsssaptisEKGFTYSFTLWSR-
>UniRef50_O02604(37-237:623) Thymidylate synthase n=87 Tax=Plasmodium RepID=DRTS_PLAVI   E=2e-23 s/c=0.54 id=26% cov=92%
-----------RGLGNKGTLPWKCNSvDMKYFSSVTTyvdeskyeklkwkrerylrmeasqgggdntsggdnthggdnadklQNVVVMGRSSWESIPkqyKPLPNRINVVLSktlTKEDVKEKVFIIDSIDDllLLLKKLKYYKCFIIGGAQVYRECLsrNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTS--VSEVYNSKGTTLDFLVYSK-
>UniRef50_Q09Q25(6-186:189) DfrA19 n=6 Tax=Gammaproteobacteria RepID=Q09Q25_KLEPN   E=8e-23 s/c=0.59 id=27% cov=97%
-LELIVAVDSKLGFGKGGKIPWKCKEDMARFTRISKeIRVCVIGKHTYTDMRDMqlekdgaeerikekgiLPERESFVISSTLKQEDviGATVVPDLRAVINLYENTDqRIAVIGGEKLYIQALSSATKLHMTIIPREFDCDRFIPvdpiqnnfHIDSSASETVEATVDETQE----RIHFATYVR-
>UniRef50_B6Q982(25-223:270) Dihydrofolate reductase, putative n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6Q982_PENMQ  E=2e-22 s/c=0.53 id=32% cov=75%
------------GIGLNGTLPWpRIKSDMNFFARVTSRpplqqtapeaeklNAIIMGRKTYYSLPkslRPLKDRLNVIISRDesgsvaaeverdlagqrekaqndgKEDKRDALVAHSLEDALSQLfekrQDLGHVYVIGGGEIYKSSLELsstltsskiVKRILMTRVkrrdEEEYECDTFFPLTDED----------------------------
>UniRef50_A8Q785(15-213:294) Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8Q785_MALGO  E=6e-21 s/c=0.51 id=34% cov=81%
-LTAIVAASLRNGIGSQGTLPWRLSKDMAYFRAVTMHvgepvhddevmdsagcvrtpvcmkNAVIMGRHTWDSIPpkfRPLRDRINVVVSTSMTrahlgssecDDHDTLIARSLDEAVALLQERRmwryraraegdatldssdvlrgsalgHAFVIGGAALYRHLLTSTsqawtlDSLLVTRIFTPVDlhekCDVFLTEF-------------------------------
>UniRef50_C5H7L7(1-173:181) Dihydrofolate reductase n=3 Tax=unclassified Myoviridae RepID=C5H7L7_9CAUD  E=4e-19 s/c=0.55 id=32% cov=96%
MIKLIFASGEHGEFGTPTGMPWpRHKQDMQEFKRLTKNNLVVMGNETFKTLGsKPLPERTNLVLTNSvpylgiDFDKDDVMYAKaskeSFGAFLKYLDSsiDEDVFVIGGAGVLVDALPYAGVVFHTVFHKVTeEATVYLPfenffdkLYDSRVFAKVQSRPSDDGKA-----TFEIY---
>UniRef50_C4YWY4(6-186:213) Dihydrofolate reductase n=1 Tax=Rickettsia endosymbiont of Ixodes scapularis RepID=C4YWY4_9RICK  E=4e-19 s/c=0.53 id=28% cov=77%
----IMACDPQGVIGNKGQIPWSYSKEFEYFYQTVKNNIIVMGRKTFDSIPaKILKNCICIVFSRNtplqsynnrhlskPTYREEfkgytersttayidnstdastgltsklpleakfgkmsiIFFIKSLDDFWQIIKpfTDKKIFMVGGTEIATLFLEqnLIDEFLLTKINKNYNGDTFFP---------------------------------
>UniRef50_A5KSY7(5-124:168) Bifunctional deaminase-reductase domain protein n=1 Tax=candidate division TM7 genomosp. GTL1 RepID=A5KSY7_9BACT  E=7e-19 s/c=0.79 id=34% cov=70%
---LIVATTADGMIGRStGHLaDWTSPEDKKLFVRLTKEaGVMVMGARTFETIGRALPGRRTIVYTSKPEsiTVEGVEATNeSPTELVARLKNEgaSGVAICGGASIYQLFMEsgLVDEVYLT----------------------------------------------
>UniRef50_C9SV29(10-169:173) Dihydrofolate reductase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SV29_VERA1  E=2e-18 s/c=0.58 id=29% cov=81%
-LTLIVAATRTMGIGRNGTLPWTgLKREMAYFARVTKRpaglgprptalNAVIMGRK---DVGgaspprfRPLKGRLNVVISRSAAP-------CCLPGAAQEVDIEK------------------DAVKVASLEEAFECDAFFPlKLGQAEgW--VKRDKGELDawvgeevdageqEENGTRYEFQMWEK-
>UniRef50_B2G4X4(1-91:141) Dihydrofolate reductase n=1 Tax=uncultured bacterium RepID=B2G4X4_9BACT  E=1e-16 s/c=0.96 id=32% cov=49%
----MVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMG-ALPNRKYAVVTRSSFTSDneNVVIFPSLNDAL-----------------------------------------------------------------------------
>UniRef50_C5JZR1(62-250:395) Dihydrofolate reductase n=2 Tax=Ajellomyces dermatitidis RepID=C5JZR1_AJEDS  E=1e-11 s/c=0.38 id=39% cov=58%
------------GIGHAGTLPWsRIKTDMAFFSRVTTRapapenatrtstsavNAVIMGRKTYDSLParfRPLPGRVNVVVTRDRSGRerariegewraagererekerknnsreggnigattttpsstpkpetgpetgpkpeeetPDVLVANSLESAVAALHDAfrttptpgplshnatrclANIFIIGGGEIYAAAL-------------------------------------------------------
>UniRef50_Q0BSG2(17-136:153) Dihydrofolate reductase n=13 Tax=Alphaproteobacteria RepID=Q0BSG2_GRABC  E=2e-10 s/c=0.56 id=23% cov=67%
------AIGSGGQLGLNGKLPWQgdqrpaFREDVRRFWERTLGHVLLCGPATYRSIP-----------ATAFTARDILELRSSMQPEDVLSRYPGRIVYIGGGlavwNTYARFIQHWD---ITRLPYDGPADRYF----------------------------------
>UniRef50_C4WJ53(15-163:188) Deaminase-reductase domain-containing protein n=1 Tax=Ochrobactrum intermedium LMG 3301 RepID=C4WJ53_9RHIZ  E=5e-10 s/c=0.44 id=26% cov=65%
IVGYIAA-SLDGFIADeNGRLDWLFKydgadlgeHDYRTFIQSI--RTVVMGRATYDFVaesdaPWAYGDQRCIVVTSRPVENPRgpLETRHDVDALIAELRalDDGDVWMLGGGQLQMAFLER-----------------------------------------------------
>UniRef50_Q9RW76(6-174:182) Putative uncharacterized protein n=1 Tax=Deinococcus radiodurans RepID=Q9RW76_DEIRA  E=6e-10 s/c=0.39 id=24% cov=72%
LLAFI-ACSLDGLIARpGGELDWlalaEEPgEDHGYAAFVSRVDTLVMGRGTFETVRdfpeWPYAGLRVIVLSRTLGEADlparlhGLLELHSgeLPNLLPLLDGAKGVYVDGG-QVLQSFIraELLDELTVTRL--------------------------------------------
>UniRef50_B0SIV0(1-138:178) Putative uncharacterized protein n=2 Tax=Leptospira biflexa serovar Patoc RepID=B0SIV0_LEPBA  E=8e-09 s/c=0.45 id=26% cov=43%
MVSLKAyiASSLDGFIAkKDGSVDWlhaekyqLEKEDFGYERFMESIDCIVMGRITFETVlqfePYPFETVPVIVVSKNPNY-------------------------------------------------------------------------------------------
>UniRef50_B4B1F5(5-135:173) Bifunctional deaminase-reductase domain protein n=3 Tax=Chroococcales RepID=B4B1F5_9CHRO  E=1e-08 s/c=0.47 id=20% cov=22%
----------------------------------------LIGYKTYQQLltfeEFPYPDKINYVFSRHHKNQDHNLV-------------------------------------------------------------------------------------
>UniRef50_D2BM01(3-131:173) Dihydrofolate reductase family protein n=3 Tax=Lactococcus lactis RepID=D2BM01_LACLK  E=5e-08 s/c=0.46 id=24% cov=48%
--------------------------------------TIIMGKKTYDWLEkeqagqWPYSDKTSYILTHQEISSTDNVVFIDKEKLTELsvnfADTDKNIWVVGGGEVIKLFLEnhWVDELQVT----------------------------------------------
>UniRef50_Q3M517(4-135:172) Bifunctional deaminase-reductase-like n=1 Tax=Anabaena variabilis ATCC 29413 RepID=Q3M517_ANAVT  E=2e-07 s/c=0.43 id=22% cov=72%
-IILFIASSLDGYIARDsGDIDWLFTDqDYGYTEFIAQIDTLIMGNKTYQQIltfgEYPYQDQEVFVFSKTysGETNNGAKYINSdWEDFIKTLRtsNGRDIWLVGGAQLIHFFLKHgfIDELILS-IH-------------------------------------------
>UniRef50_Q11VJ7(4-135:176) Dihydrofolate reductase family protein n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11VJ7_CYTH3  E=5e-07 s/c=0.42 id=17% cov=49%
--------------------------------------AVIVGRKTYDkvismGFDFPHADKDAYIITRTPRPSIGSIkfYTDDLKSLVNKLKseNGKNIFCDGGAEIVSELLkdDLIDEFIISVI--------------------------------------------
>UniRef50_D1AII1(7-126:188) Bifunctional deaminase-reductase domain protein n=1 Tax=Sebaldella termitidis ATCC 33386 RepID=D1AII1_SEBTE  E=7e-07 s/c=0.46 id=22% cov=43%
--------------------------------------TIIMGRKTYDQIltfgEWVYKGKDTYVLTSDISrvpEKPNIEFRNDeIEDLTTELKQKSKsnIWLLGGAETVNAFLEK-----------------------------------------------------
>UniRef50_Q6AQD9(3-138:179) Similar to dihydrofolate reductase n=1 Tax=Desulfotalea psychrophila RepID=Q6AQD9_DESPS  E=1e-06 s/c=0.40 id=23% cov=70%
-VSVYIATSLDGYIARaDGDISWLReagssagQEDYGYgefFRSV---DCMILGRKSFEtvlSFPtWPYTGKRVIVLTKTLEEIParvrgRVELYSGLMKELvasLEAEGCRRIYIDGG-KIIRSFLrkNLLTDITITRI--------------------------------------------
>UniRef50_D2RU55(6-139:184) Bifunctional deaminase-reductase domain protein n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RU55_9EURY  E=3e-06 s/c=0.40 id=21% cov=48%
---------------------------------------LVMGSRTYEQLlsfdGWPYGERPTFVVTSRDLPLATAHvelVAGNLRELVDGLEErYDRIWLVGGAALAQSFLRegLVDEIRLTVV--------------------------------------------
>UniRef50_Q38V13(9-137:179) Putative dihydrofolate reductase n=1 Tax=Lactobacillus sakei subsp. sakei 23K RepID=Q38V13_LACSS  E=3e-06 s/c=0.41 id=24% cov=48%
--------------------------------------TIIMGRKTYEQCIKlagtyPYQEKQSYVFSKTlhDTADRTNVVTGNVPEFVRqlKAQDGGNIWLVGGAETFTMLLKaqLVDELIIT----------------------------------------------
>UniRef50_Q03E11(5-139:177) Dihydrofolate reductase n=23 Tax=Lactobacillales RepID=Q03E11_PEDPA   E=5e-06 s/c=0.39 id=27% cov=39%
--------------------------------------TVIMGRTTYEQVtqklspeKYVYADRQTYIVTSHlgEDTDKIKYWKQSPVELVKRIQKEkgKDVWIVGGAKL------------------------------------------------------------
>UniRef50_A7NI56(8-143:175) Bifunctional deaminase-reductase domain protein n=1 Tax=Roseiflexus castenholzii DSM 13941 RepID=A7NI56_ROSCS  E=1e-05 s/c=0.37 id=19% cov=43%
--------------------------------------TLLMGRKTYEALslddpayGHLFADKEIIVFSRTLRFQEHSRATIVAELTLNYVDQlrrqpGRDIWLFGGGELFRALLEL-----------------------------------------------------
>UniRef50_B9J4U0(5-132:173) Dihydrofolate reductase family protein n=75 Tax=Bacillaceae RepID=B9J4U0_BACCQ  E=2e-05 s/c=0.39 id=26% cov=65%
-IVLFIAASLDGYIAKENdDLEWLMetegEGDNGYTEMYETIDTIIMGKRTYDYVvehmeTFPYVDKKCYVFSnSEKGSNEHVEFVNeDVVEFTKRLKEQEgsKIWMVGGGSLLREF--------------------------------------------------------
>UniRef50_C4RMP5(66-150:226) Deaminase-reductase domain-containing protein n=3 Tax=Actinomycetales RepID=C4RMP5_9ACTO  E=2e-05 s/c=0.59 id=27% cov=47%
--------------------------------------TVLMGRATYEpalraGIASPYAHLRQYVFSRSlpPSTAPGLEVFAgDPVAFVRELKGRPggDIWLCGGGNLAGQLLPEVDELVV-----------------------------------------------
>UniRef50_C0D168(5-126:181) Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme DSM 15981 RepID=C0D168_9CLOT  E=3e-05 s/c=0.41 id=28% cov=43%
--------------------------------------TLIMGRATYEQVKtqlspdsWPYEGKECYVVTSQflEDTDEVTFWPGDVWELVFLLKQRsgKAIWLVGGAKLLKSFMEQ-----------------------------------------------------
>UniRef50_Q03QC9(9-133:177) Dihydrofolate reductase n=1 Tax=Lactobacillus brevis ATCC 367 RepID=Q03QC9_LACBA  E=3e-05 s/c=0.40 id=25% cov=48%
--------------------------------KMTT---AIMGRVTYDTIAEsastltlnPYnPTMHSYVLT-QCPYQDTATITFTSEDLLGLArrlkQQSGNVWIIGGQAILTPLIadDLIDELYL-----------------------------------------------
>UniRef50_C7ZMP1(8-142:263) Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7ZMP1_NECH7  E=4e-05 s/c=0.37 id=29% cov=41%
----------------------------------------VMGRKTYEtmlSFGEPnenplsnRPKKSVIVASQSlkpEDFPDITILSMNVLEFIRQLKlgTGKDIWLMGGSKLATQCM-------------------------------------------------------
>UniRef50_A6AQG1(1-135:177) Riboflavin biosynthesis protein RibD C-domain protein n=5 Tax=Vibrio harveyi group RepID=A6AQG1_VIBHA  E=6e-05 s/c=0.36 id=23% cov=67%
------ATSLDGYIAdKQGKLDWlqSVPNpdniDTGFFSLMERIDGLVMGRNTLDVVlsfdcDWPYS-KPVFVLSNTMTevpqgYEDKVFLVKGeLKDVLAdlNAKGFNELYIDGGVTI-QNFLkeDLIDEMVITR---------------------------------------------
>UniRef50_B8DBD6(6-131:174) Riboflavin biosynthesis protein RibD C-domain protein n=18 Tax=Listeria RepID=B8DBD6_LISMH  E=7e-05 s/c=0.39 id=24% cov=48%
--------------------------------------TVVMGRTTYQQIFsltdtFPYSKKDVYVFSNTKagTKDEYADFVAGTVDTWLNNIDGEKIWLVGGAKLVQQFLKEkaIDRFVIT----------------------------------------------
>UniRef50_A8GLV1(2-43:46) Dihydrofolate reductase n=1 Tax=Rickettsia akari str. Hartford RepID=A8GLV1_RICAH  E=8e-05 s/c=1.15 id=30% cov=25%
---------------------------------------------------------------------------------------DKKIFIVGGAEIAILCLEqnLIDEFLLTKINKNYDGDTFFP---------------------------------
>UniRef50_D0LSH2(10-136:184) Bifunctional deaminase-reductase domain protein n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LSH2_HALO1  E=9e-05 s/c=0.38 id=22% cov=42%
--------------------------------------ALLMGRRTYEVVaamdgDWPYGNRPVLVATHRPlDNAPRTVHAvsgdiASMVETACQAAGERDVYIDGG-ELLRQALD------------------------------------------------------
>UniRef50_P37508(10-152:188) Uncharacterized protein yyaP n=15 Tax=Bacteria RepID=YYAP_BACSU   E=0.0001 s/c=0.33 id=19% cov=65%
-IILDLAVTLDGFIeGKNGEVDWCIMDpDMGFTDFLNQIDTILYGRKSFDLWGqyipknedpdtekelwKLVHSKKKYVFSRTQNEIDNqaIFINDNILEEVNKLKKNPgkDIWLYGGASLITTFI-------------------------------------------------------
>UniRef50_Q02D24(1-131:184) Bifunctional deaminase-reductase domain protein n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q02D24_SOLUE  E=0.0001 s/c=0.36 id=27% cov=65%
MIaqrKIIVyiATSADGYIARpDGDVEWLNRRphtiDygMKAFYRTI--DTILWGRKTYDWLlayhkKHGLKGEmfdtkvANFVLSRKPpkRAAPGVEFVAEPVKKFArrlRAEPGKHIWMMGGGELIASFLD------------------------------------------------------
>UniRef50_Q7N8I1(1-139:183) Similar to unknown protein n=2 Tax=Gammaproteobacteria RepID=Q7N8I1_PHOLL  E=0.0002 s/c=0.34 id=25% cov=38%
--------------------------------------AVIMGAQTYEWImtnspdDWPYKNVPAFVLShRALSTPEGLniiitnETVRVIAAKAKKMANGKDVWLVGGGK-------------------------------------------------------------
>UniRef50_A0QP85(8-134:175) Dihydrofolate reductase n=3 Tax=Mycobacterium RepID=A0QP85_MYCS2   E=0.0003 s/c=0.36 id=20% cov=35%
------------------------------------------------------------VLTHRPEIAAESHPmqvfsgdVAELHPELVAAAGGKDVWVVGGGDVAAQFVaaDLIDEIIVSY---------------------------------------------
>UniRef50_B0TSJ9(15-144:184) Bifunctional deaminase-reductase domain protein n=21 Tax=Bacteria RepID=B0TSJ9_SHEHH  E=0.0007 s/c=0.35 id=22% cov=48%
--------------------------------------ALIMGRNTLEivlsfGIDWPY-NKPVFVLSNTLTEVPaelegkAFIINGELEHIVQQLnsKGYQNLYIDGGKTI-QGFLqrDLIDELIITTI--------------------------------------------
>UniRef50_Q65IB5(1-161:162) DfrA n=4 Tax=Bacillaceae RepID=Q65IB5_BACLD   E=3e-55 s/c=1.34 id=44% cov=101%
MISLIAAMDRNRLIGKDNDLPWHLPQDLKYFKEVTKGHAVIMGRKTFESIGRPLPHRENIIVTSNKELDiPNCQVMHSAEEAVRFAKNrNEECFVIGGSTLYTEILPFADKLYVTKIDETFEGDRYFPEFSEAEWEIVSRRKGLKDDKNPYDYEFLVYQRK
>UniRef50_P27498(1-159:159) Dihydrofolate reductase n=89 Tax=Gammaproteobacteria RepID=DYR_KLEAE  E=4e-55 s/c=1.35 id=89% cov=101%
MISLIAALRVDRVIGMENAMPWNLNEDLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNIVISSKPGSDDRVQWVSSVEEAIAACGDVEEIMVIGGGRVYDEFLPKAQKLYLTHIDAEVEGDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR
>UniRef50_B0MUX5(1-159:160) Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MUX5_9BACT  E=8e-55 s/c=1.35 id=39% cov=101%
MIAIIVAVAENGVIGGDNRLLWHISEDLKHFKAVTTGHPVVMGRKTYESLGRPLPGRRNVVVTRQNISIEGCDVVHSLDEALALFRPEEKVFVIGGAQIYAQALPLCDEFYLTRVFHAYQGDTCFPRWDEREWEIIDSESFASGKEFPYPFAFEHYRRR
>UniRef50_A5FJX2(1-160:160) Dihydrofolate reductase n=1 Tax=Flavobacterium johnsoniae UW101 RepID=A5FJX2_FLAJ1  E=1e-51 s/c=1.27 id=37% cov=101%
MIIMIAAVAENNTLGKNNELVWHLPNDFKRFKSLTTNHHIIMGRKTFESFPKPLPNRTHIIITRQTDYnPEGCIVVDSMEKAIAACPENEDSYIIGGGEIYNLGLPYADIIEITKVHHTFEGDAFFPKISKSEWQLVESEENFKDEKHLYDYTYETYIRK
>UniRef50_C9RIZ1(2-162:163) Dihydrofolate reductase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RIZ1_FIBSS  E=2e-50 s/c=1.24 id=38% cov=100%
LISAIVAVSENNVIGRDGHLPWHLSADLKRFKAITTGHAIILGRKNYDDIGRPLPNRTNYVLTRNKDFQaPGCIVCSSLGEAIEAARaaGETECFIIGGAAVYREAMPLVEKLYLTRVLSHVEGDVFFPEWN-DKFQKESAESFPADEKNDFPTTFEIWVRK
>UniRef50_Q67JQ2(1-150:165) Dihydrofolate reductase n=1 Tax=Symbiobacterium thermophilum RepID=Q67JQ2_SYMTH  E=3e-50 s/c=1.33 id=44% cov=94%
-------MGRNRAIGREGRLPWRLPAEMRHFRRTTMGKAVVMGRRTYESIGGPLKGRTNIVLTRDPGFrAPGCEVRHSVAELLQ---DRRPLYVIGGAEVYRQFLPHADEMILTRIDHDFEGDAFFPAWSEDEWELVGSTPHPRDEENPYDFVVEHYRRR
>UniRef50_C7RLL7(1-169:169) Dihydrofolate reductase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RLL7_9PROT  E=4e-49 s/c=1.15 id=39% cov=101%
MISLIAAVARNGAIGRNQQLLWRLPEDMRYFRETTSGKTVIMGRKTWESLPpayRPLPNRRNIVLSRNPAYLPrGGDLACSIEDALRLAGGAAEVFIIGGEELYRQTMPLATRLYITEVAEESPGDAFFPDVASGEWREISRRvgrsraAGSALRDQAPAFDFVVYERR
>UniRef50_Q04F50(1-164:170) Dihydrofolate reductase n=2 Tax=Oenococcus oeni RepID=Q04F50_OENOB   E=9e-49 s/c=1.18 id=40% cov=101%
MITSIWAQSKNNVIGRNNHLPWSLPDDLKFFRQETKNKAVVMGRKTYESFGsKALPKRLNIILTSNMDFksnDPEVKIVHSPIEAVNTAKEQHlPLYVIGGASVYESFMNMADRLLITLVDANIKGDTFAPNFSEKSFSLVSQCHHAQDKKHAYSFDFLTYERK
>UniRef50_Q9RR65(17-175:180) Dihydrofolate reductase n=2 Tax=Deinococcus RepID=Q9RR65_DEIRA   E=7e-48 s/c=1.20 id=41% cov=99%
-IVAIAAQTENRVIGRDGGMPWHLPADFAHFRALSVGKPNIMGRKVFDTLRRkPLPERVNIVLTRNENLKfDGCLIAHSPEEALQLAGDAPEIAIIGGEEIYRLYWDRLTRLEMTLIHAELDGDTFFPEIGP-EWELAQETFRPADEKNRYDLTFQTWRRR
>UniRef50_D1BNV5(1-161:164) Dihydrofolate reductase region n=4 Tax=Veillonellaceae RepID=D1BNV5_VEIPT  E=9e-48 s/c=1.19 id=34% cov=101%
MLALIVAVAHNRVIGKDNTLIWHLPNDLKFFKEKTTGHVIIMGRKTFESLPFLLPNREHWVITRDKgfDAPEGVKIFHNPEAAAEAARALDAAYVIGGAQVYEAFLPYVDTMYITEVDHEFDGDAFFPEFSEDAFTIESVVDGIVDEKNQYPHRFVTYRRK
>UniRef50_B3ER85(1-163:164) Putative uncharacterized protein n=1 Tax=Candidatus Amoebophilus asiaticus 5a2 RepID=B3ER85_AMOA5  E=7e-46 s/c=1.13 id=41% cov=101%
MIkSIIVAKAVNHVIGNKGRLPWHMPADLKHFKELTGGHHVIMGRKTFESLPGSLPDRKIIILSQSLNYKvEDCTVVPSLEMALEIANqaNETEVFIAGGAAVYREALGIVDKIYLTVIHTDVEGDTFFPTLKDHQWTEVSIVSHNHDIKHAYAYDFIELAKR
>UniRef50_B2I6E9(24-186:188) Dihydrofolate reductase n=11 Tax=Xanthomonadaceae RepID=B2I6E9_XYLF2  E=1e-44 s/c=1.10 id=45% cov=101%
IVSLIAALDRYRAIGRDNGLPWHLPDDLKRFKALTLGRPVLMGRKTAHSLGRPLPGRTNLVLTRSGHVPfSEMRAVDSLDAAIvqAAAEGADTLSVIGGGELYALTLPHANAMYLTHVDVAVAGaDTYFPMFDAVDWEIKNREPHQGDGRHAYPFTFIDYCRR
>UniRef50_A4BS77(1-153:162) Dihydrofolate reductase n=1 Tax=Nitrococcus mobilis Nb-231 RepID=A4BS77_9GAMM  E=2e-44 s/c=1.17 id=40% cov=96%
-------MAENRVIGRAHGLPWRLPADMRHFVALTRGKPIVMGRRCHDTIGRALPGRHNIVLSRNPaHRVPGCMLVHDLEAALAVAAGASEIMIIGGEQIYRLFLARADRIYLTLVHGRVEGDAFFPHLDAAEWQESARQSRLADADNAYALTFLTLLRR
>UniRef50_A8YUW1(1-167:172) Dihydrofolate reductase n=12 Tax=Lactobacillus RepID=A8YUW1_LACH4   E=2e-44 s/c=1.07 id=35% cov=101%
MIEFVWAEDQKHQIGLDGHLPWRLPADMAHFKEKTIGHPIIMGRKTFMSLPRLLPQRKHIVLTHDQDLkkkyqdNDQVTIINSIAELGDYIQNHqgEKLCTVGGVSIFKALLDQVDVLEKTEIDATFEADTVMPEIDYDQFKLVKKEHHEADEKNKYPYTFFTYQRK
>UniRef50_B5EIA1(2-155:306) Dihydrofolate reductase region n=5 Tax=Geobacter RepID=B5EIA1_GEOBB   E=2e-42 s/c=1.12 id=38% cov=97%
IISTIAALSDNRVIGADGGLPWDIPSDLTRFRSITMGHTVIMGRKTYESIGHPLLGRRNIVLTRKGSQIEGCEIARNVPAAIAAAEGEEEVFICGGGEVFQEALPLCQRLYLTVVHGNYRGDAFLPEL-PEGFVELHREEFP---DTTPPSSFVVLEK-
>UniRef50_Q044A0(3-169:171) Dihydrofolate reductase n=13 Tax=Lactobacillus RepID=Q044A0_LACGA   E=6e-42 s/c=1.02 id=38% cov=101%
MIRFIWAEDEDGHIGYQGTLPWHLPADLKHFKDLTSNHIIVMGRRTFESFPGLLPKRQHIILSTSPTlqrkyqNNAHVKIFSQLKELKNWIKDHSEqtIDIIGGARVFEEFMDEVDMIEKTKIHHVFKGDTLMPKINYEDFELINTKAHQADEKNKFAYDFLEYERK
>UniRef50_A0JZC8(23-191:194) Dihydrofolate reductase n=11 Tax=Bacteria RepID=A0JZC8_ARTS2   E=1e-40 s/c=0.99 id=38% cov=99%
-VGLVWAQTTAGVIGKDGDMPWHLPEDMKHFTRLTTGHPVIMGRKTWLSFPdkyRPLPGRTNIVVTRQEGWGDtpdarGAIAVKSLDDALLEsqfAPGHETVWVLGGGEIFAQTLDIADVAVVTFIDSETDGDTYAPELGY-EWKLAASEPatGWLTSATGTRYRFTMWRR-
>UniRef50_Q14P23(1-157:160) Putative dihydrofolate reductase oxidoreductase protein n=1 Tax=Spiroplasma citri RepID=Q14P23_SPICI  E=2e-39 s/c=1.04 id=29% cov=96%
MIKLLWAMDENNLIGQNDQLPWHLREELQHFKETTLGQTILFGRLTYEGIGWPLPKRKTLVLTRHLDYqikHPDVEVVTDLTAIINFYHQnpTEDIYICGGKKIYEATLPYADELIISLIKGKYQGDTYFPSFDLNQFTLIKLNEYQQ-------FVIKYYKRK
>UniRef50_Q3A0W8(16-167:167) Dihydrofolate reductase n=1 Tax=Pelobacter carbinolicus DSM 2380 RepID=Q3A0W8_PELCD  E=4e-39 s/c=1.07 id=36% cov=96%
-MTIVVAMTAERIIGRRGQLPWSIPEDLALFRRLTYGHTLVMGRRTFESIGRPLPGRFNIVVSRSMPPVEGLRVCRHFAEALQVADQGNgDIFFIGGCEIYRQALIVAGKLSVSWIRKNYPGDCRFPEYRSDDWLIEQEQDYSE-------FRHIIYRRR
>UniRef50_Q3F0Y0(1-171:172) Dihydrofolate reductase n=2 Tax=Bacillus thuringiensis RepID=Q3F0Y0_BACTI  E=7e-39 s/c=0.94 id=36% cov=101%
MISLIVAADENNAIGFENKLLCRLKDDMKHFIKKTKGKPIIMGYKTFASLGhKPLKDRFNIVLTRSPmaltldhlHLVGENLVFESLEyiQFMIEQSKDKEIVVIGGQQTYELFLPMASRVYLTRIHHSFpEADSYFPMLDSSEWSSKLDAKHAESEDNDHPFSIYTFERK
>UniRef50_C7R3F1(11-171:191) Dihydrofolate reductase n=1 Tax=Jonesia denitrificans DSM 20603 RepID=C7R3F1_JONDD  E=3e-38 s/c=0.99 id=36% cov=97%
-LSLIWAQSLNGVIGRSGTIPWHEPTDLAHFQKTTRGGVVIMGRHTWESLPvTPLPQRVNIVLTSDRDYrAPGARVVTTPQQALDLAHwytqvGHQAIWVIGGRQVYDTFMDYATQLIVTTVGTVIEGDTEAPRIPP---HFVPQEPHQLATHSDYEVTVTTWLR-
>UniRef50_C4Z7Z2(1-161:163) Dihydrofolate reductase n=34 Tax=Bacteria RepID=C4Z7Z2_EUBR3   E=4e-38 s/c=0.98 id=30% cov=98%
-MNLIAAVDNNWAIGKNNQLLVRIPMDQKFFREMTTGKVVVMGRKTLESFPnsRPLKNRTNIVLTHNPSYEvEGAVVVHSLDELHKELEkyNSEDIYIIGGQKIYEQLVDECDVAHITKVDFEYDADAYFPNLDEKpEWQIT--GDSEEQTYFDLEFYFLRYEK-
>UniRef50_B3RI81(1-173:174) Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RI81_TRIAD  E=3e-37 s/c=0.90 id=35% cov=95%
-------MTRDRGIGYKNDLPWKLRNEYKYFARLTTStkdsakkNAVLMGRNTWVSIPeknRPLRNRINIVISsqlRAEEVPEGVHVVASIPEVIELVQSpllkdiVETVWIVGGAPVYKGFMshPQCDRIYLTKLDANYECDVFFPEM-SDDFKEISdpDVSQEVQEENGLKYTFHVYQR-
>UniRef50_P17719(5-180:182) Dihydrofolate reductase n=21 Tax=Endopterygota RepID=DYR_DROME   E=4e-37 s/c=0.88 id=32% cov=97%
---LIVAVCENFGIGIRGDLPWRIKSELKYFSRTtkrtsdpTKQNAVVMGRKTYFGVPeskRPLPDRLNIVLSTTlqeSDLPKGVLLCPNLETAmkiLEEQNEVENIWIVGGSGVYEEAMasPRCHRLYITKIMQKFDCDTFFPAI-PDSFREVapdSDMPLGVQEENGIKFEYKILEK-
>UniRef50_C0QWN0(2-165:166) Dihydrofolate reductase n=2 Tax=Brachyspira RepID=C0QWN0_BRAHW   E=8e-37 s/c=0.94 id=36% cov=98%
IVSLIAAVDSKNGIGLNGVMPWgHIKEDMQFFRSTTTGYAVIMGRVTFESLGsKPLPNRKNIVISSNVNTEllnkyDNLFYEKSFEDSISklLLEKNKQIFIIGGESIYKKALDYADMIYLTHIDKDYHCDRFFPEIDTNLFQ---SDELKTFFYNDISVNIIKYTR-
>UniRef50_Q0G0R9(11-172:178) Dihydrofolate reductase n=2 Tax=Aurantimonadaceae RepID=Q0G0R9_9RHIZ  E=4e-36 s/c=0.94 id=35% cov=98%
----VVAAAKNGVIGADGGMPWSIPSDLKRYRSLTMGKPMIMGRKTLEAIGKALDGRDSIVLTRENRLAvDGAMLASGPAEAIAKaiecasARRASEIAVVGGAEIYRLLWDHIDRIALTEVDAEPEGDAVFPAIDESEFELLSEEPWIRGERDSAATRFKSYQRR
>UniRef50_B4D395(1-182:201) Dihydrofolate reductase region n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4D395_9BACT  E=1e-35 s/c=0.82 id=39% cov=91%
-------MSLNRVIGRDNKIPWHLPEDFKWFKKLTTGHFVLMGRKTFESLGRPLPNRTNIVVTRKPlrlardpqfkatvgqarvghwqarfgrpyqlgferLSERDVWLVRDprkLADAFEKARPSRQLFVIGGAQIYEQLLPRCTDLYLSVVQREVEGDACFPEL-EDDWYLHDTPLRTPD------FEVQHYRR-
>UniRef50_B9YFM0(3-165:166) Dihydrofolate reductase region n=3 Tax=Nostocaceae RepID=B9YFM0_ANAAZ  E=2e-35 s/c=0.91 id=34% cov=97%
LISLIAAISENRILADSKkehirvGIPWDIPSDLQHFQKKTWRHPVILGRKSYAAFNHPLPNRTNIILTRSHDYkAPGCLVFYSLSEAVTWAKmsEKEEIFIAGGGEIFAEAIKFANKLYLTIVEGNFEGDVYFPEF--TNFGTVTKEEH--SQENDFQFKFVEIER-
>UniRef50_D2SDU7(3-163:176) Dihydrofolate reductase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SDU7_9ACTO  E=8e-35 s/c=0.92 id=41% cov=87%
-VGLVWAQARGGVIGADGRLPWHLPEDLRLFRELTTGSTVVMGRRTWESLPerfRPLPGRRNVVLTTDRSWaADGAERVDGVEDVLARTDDG-DLWVIGGGRVYAAFLPHADRVVVTDVDTDVEGDTWAPQLG-AEWARVSRTP-------------------
>UniRef50_UPI00017450E9(8-169:179) dihydrofolate reductase type III n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI00017450E9  E=8e-34 s/c=0.89 id=32% cov=98%
-LTLIAAVDENLLLATAQGIPWKLPDDVAHFRAYCAGKWLLLGRHTYEDMtGWFKPDQHPLVLTSTCGYEPNpGRGVASVPQALALaeAEGQEELVCIGGGQVFATALPHATRLVITHIKHIFEpGDqpVYFPPISADAWREERRLDHAVDDRHAWPFTFVEY---
>UniRef50_A8RBH0(1-134:153) Putative uncharacterized protein n=1 Tax=Eubacterium dolichum DSM 3991 RepID=A8RBH0_9FIRM  E=9e-33 s/c=1.05 id=26% cov=84%
MIAMIVAVDKNGLIGNKNRLPWHCPEDLKHFYRTIKNHELLMGKRTFDSI-RLKDNVVHVVTHQTIKEQDNIRICTDLSAFLKqWQTSEKTLFVCGGASIYQQAFPFCSEAYVSVIDGEYQGDCYLPPMDFSLFQ-------------------------
>UniRef50_Q4SM73(11-190:198) Chromosome 13 SCAF14555, whole genome shotgun sequence n=2 Tax=Tetraodon nigroviridis RepID=Q4SM73_TETNG  E=2e-32 s/c=0.77 id=27% cov=98%
---LIAAKCNGGGIGKDNRMPWSLPSEFRFFLSTITRvsrpgkmNMIIWGKQCWISHPEstfPLPNVLHTVLSTTLFAVPDhaHFVCETLDAAVRLASEppladlIEIVWIVGGVQVYKEAMehPWCDLIYLTDIMAEFECDVFFPEFDRQLFQVQDgfpDVPDGIQEENGIKYKCQVYKR-
>UniRef50_A9VA22(3-147:205) Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VA22_MONBE   E=8e-31 s/c=0.92 id=37% cov=77%
-VALVVAATKAGGIGHQGQLPWHLKADMQHFRDITTkteqpaaINAVIMGRKTFESIPdkfRPLHGRLNVVLSTQKpatlNYPPGVLVASSLQEAFEFLDISPEVietaYIIGGASVYNEALakpEYSHYIFMTKVHKDVLCDT------------------------------------
>UniRef50_P0ABQ7(1-165:169) Dihydrofolate reductase type 8 n=2 Tax=Enterobacteriaceae RepID=DYR8_ECOLX  E=5e-30 s/c=0.80 id=31% cov=97%
MIELhaILAATANGCIGKDNALPWpPLKGDLARFKKLTMGKVVIMGRKTYESLPVKLEGRTCIVMTRQALELPGVrdangaIFVNNVSDAMRFAQEEsvgDVAYVIGGAEIFKRLALMITQIELTFVKRLYEGDTY---VDLAE--MVKDYEQNGMEEHDL-HTYFTYRKK
>UniRef50_D0LYN1(26-195:202) Dihydrofolate reductase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LYN1_HALO1  E=6e-30 s/c=0.77 id=31% cov=96%
---LVVVADLDGGIARKGEIPWHLSADLRHFQQLTrttaepaQQNAVIMGRKTWESLPaasRPLPSRRNIVLSRDaeLTLPPGVVHAAELEAALAATDlatpPIDRRFIIGGKGVYAEAMQRrgCRHIFYTEIQDRFDCDLFFPAF-KDRFKRT--DLLAEGEEKGIGYRIEVWTR-
>UniRef50_B6AE97(22-204:549) Thymidylate synthase family protein n=4 Tax=cellular organisms RepID=B6AE97_9CRYT  E=2e-29 s/c=0.71 id=36% cov=97%
VIIIVAASTKEKGIGKGNNLPWSIKEDLKFFREITcstieqsqddkentkieKVNAIILGRKTWDSMKRiPLKNRKVIVLSRtlqrcDNKNDSGVSIVKSLDEAINLCNNDisiHKIVICGGESIYRECIEKniVETIYLTRVSTSkKEFDTYFPNIPES---FVPILMSQTFCCNDISYDFMIYE--
>UniRef50_C2CWT0(7-201:210) Dihydrofolate reductase n=1 Tax=Gardnerella vaginalis ATCC 14019 RepID=C2CWT0_GARVA  E=4e-29 s/c=0.66 id=37% cov=97%
---LIWGQAYDlegrvGAMGVNGGMPWRLSTDLRYFKAMTISCPVIMGRGTWDSMPekfRPLPGRENIVVSRNPDFNsDGAKSFTSIEEAICYAkkwiednpiehvdssdlpKDGSAVWIIGGGAIFREVIEsqIVDAAYVTQIDTRVEADTFAPNIqklvDDGLWKVARDCDWQESTikvganQFNTKYKFMVYE--
>UniRef50_C5MGL9(6-194:194) Dihydrofolate reductase n=2 Tax=Saccharomycetales RepID=C5MGL9_CANTT  E=2e-28 s/c=0.67 id=33% cov=100%
VISIIVaALKPSLGIGNNGKMPWRLRKEIRYFKDVTskttvenSRNAVIMGRKTWESIPvkfRPLPDRLNIILSRsyeNEIIDENIIHANSVESSLSFMSNIDRVFIIGGAEIYNDLInnPLVTQLLITEIEHsnpeSVEMDTFL-KFPLEKWTKQPKselQKFIGDEitledninEGDFTYNYTLWTRK
>UniRef50_Q5V3R2(9-175:185) Dihydrofolate reductase 1 n=1 Tax=Haloarcula marismortui RepID=DYR1_HALMA  E=6e-28 s/c=0.74 id=32% cov=88%
-LVLVVAADENNVIGLDGGVPWHYPEDVRQYKNRIAGHPIILGRRTFESM-KPIPDCYTVVLTsddRRSADSETVEYATTPQiaveaaaragasgafagDSAGADSSPPVTYVIGGEAVYDLFLPFAGRVFLSRIHEHNEGDRYFPDLG-AEWTELSREPHD-----------------
>UniRef50_C5DEY6(8-221:237) KLTH0D10802p n=1 Tax=Lachancea thermotolerans CBS 6340 RepID=C5DEY6_LACTC  E=1e-27 s/c=0.58 id=31% cov=99%
IVTIVACLMPEMGIGYNGKLPWRLKQEMAYFRQVTsatfadgKRNAVIMGRKTWESIPpkfRPLPDRVNVVVSRQFaedlapaqSSAPGsklsshagaaapaspalwlsNSLTRCLDLLPQRVPDLERIYVIGGAEIYAQSNSLCDYMLITKIEPEsaterPPMDAFldtqsihalfqhdqsLPSFLPPA---VSLPADPYISENGYRYNFALYRRR
>UniRef50_C2KQT3(55-204:227) Possible dihydrofolate reductase n=2 Tax=Mobiluncus mulieris RepID=C2KQT3_9ACTO  E=3e-27 s/c=0.81 id=36% cov=85%
-LGVIWAEDCHHVIGAGGGMVWRVPDDLRFFKETTMGCPVIMGTGSFKALGEPLKGRRNIILTRHPSALADftreglIETASNLDDAIKLCAGTKEVWITGGGVVYQEVMDagIADLLVVSQLDliAPVPPDakvTVAPVIDPQRWQL------------------------
>UniRef50_Q75BZ5(8-206:211) ACR124Wp n=1 Tax=Eremothecium gossypii RepID=Q75BZ5_ASHGO   E=1e-25 s/c=0.59 id=32% cov=79%
VVSIVACLLPEYGIGYQGQLPWRLAREMKYFRQATTatfdptkRNAVVMGRKTWESIParwRPLPGRLNVVVSRTytspwaHDENGHVITSNSLQQCVRQLQEqaralgVERIYIMGGAEIYNQSYDLCDHLLVTELQVAPDGpavllDTF-----------------------------------
>UniRef50_D2E8H0(1-224:227) ORF119 n=1 Tax=Anguillid herpesvirus 1 RepID=D2E8H0_9VIRU   E=2e-20 s/c=0.45 id=26% cov=95%
---LIVARNLNGAIGRGGRLLYKLPKDLQRFRDLTQDQIIVMGRKTFETLPRVLPRRRHVVLSKSapainihdpclqelATNREGVWIrnwtveqVRSLESLPRLLSPADktrttcqinqikpkdclysflpaqarvsgaeidktarsKLFIIGGAEVYNLFWKHCSVLHITKVVASE------PKPRHEEEDLVSWAVSDSQlrtlfdltlsvpcHDNGFGIIFETWRKK
>UniRef50_Q04515(3-137:187) Dihydrofolate reductase type A10 n=4 Tax=Gammaproteobacteria RepID=DYR10_ECOLX  E=2e-17 s/c=0.67 id=31% cov=79%
-ISLIFANELiTRAFGNQGKLPWQfIKEDMQFFQKTTENSVVVMGLNTWRSLPKMKKlGRDFIVISSTITEHEvlnnNIQIFKSFESFLEAFRDTTKpINVIGGVGLLSEAIEHASTVYMSSIHmvKPVHADVYVP---------------------------------
>UniRef50_A7HNA2(27-168:197) Dihydrofolate reductase region n=1 Tax=Fervidobacterium nodosum Rt17-B1 RepID=A7HNA2_FERNB  E=7e-16 s/c=0.60 id=34% cov=72%
---LLAVTDIHGVIATmeSDDISWGSREDKALFKEITTsSGVVVMGRKTFESIGKKLPNRFNVVLTKKTieyfenlDYKPDLILSCSSREAVETLNkmGYNDICVIGGQSVFTQFL---NEGIVTDIHLTIE---------------------------------------
>UniRef50_Q8MVZ6(1-135:255) Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Diplonema ambulator RepID=Q8MVZ6_9EUGL  E=2e-15 s/c=0.62 id=33% cov=73%
----------------------------------------VMGSKTWESIPekfRPLEGRLNIVLSRDMKQEDvkgldnVVVVNGGLTDALTLLGEkeylakVDRVFVIGGGSLYNEAlaapcLPILHNVYLTQVEGEFDCDTFVAFTPGKSFREVSK--SEAEDKN-IKMTMYHYSK-
>UniRef50_Q6J3S1(3-102:123) Dihydrofolate reductase n=1 Tax=Escherichia coli RepID=Q6J3S1_ECOLX   E=3e-12 s/c=0.73 id=27% cov=61%
-----------------------------------------------------LPNRKYAVVSKNgiSSSNENVLVFPSIENALKELSKvTDHVYVSGGGQIYNSLIEKADIIHLSTVHVEVEGDIKFP-IMPENFNLAFEQFFMSNINSYIP---------
>UniRef50_B5JMA5(1-132:174) Riboflavin biosynthesis protein RibD C-terminal domain protein n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JMA5_9BACT  E=2e-10 s/c=0.51 id=26% cov=72%
MLTLIAAQTLDGFIARQNQpgTDFCSDADAAFLRSALKDfDSLVMGRKTYDTLRDRIQNSDTTrylrkIVTRDPashaaDTKPDLVEFTSapPDEILAELakRGRNKTALLGGGEIYTRFLSagLVDELWIT----------------------------------------------
>UniRef50_D2QTS7(4-174:182) Bifunctional deaminase-reductase domain protein n=2 Tax=Flexibacteraceae RepID=D2QTS7_9SPHI  E=3e-09 s/c=0.37 id=20% cov=71%
-LILYIATSLDGYIARaDGRVDWleSIPNpdqlDYGYADFLASVDTTLMGNSTYQTIlsfggDFPYADKLNFVFSRQTSLTDTDyvrFVHEDPATFVKSLKNQPgkDIWLVGGGQLNTILLNagLIDQFIIT----------------------------------------------
>UniRef50_C8V2J6(1-181:215) DHFR, dihydrofolate reductase, cytosolic form (Eurofung) n=2 Tax=Emericella nidulans RepID=C8V2J6_EMENI  E=4e-09 s/c=0.35 id=33% cov=61%
-----------------------------------------MGRKTYDSIPprlRPLGKRLNVVISRDPDGSVaervkidlesklerereaaeakakqqpqnqaegrnsgeepvnaaavtavvappvkegstGAFVERSLEEALRRLDNaaageegVGNIYVIGGAEIYNASLKLGSrsenertiRIVMTDVEKLdgsgFECDTFFPvdaeELNSGKWRKVS----------------------
>UniRef50_Q8THH7(8-128:198) Putative uncharacterized protein n=1 Tax=Methanosarcina acetivorans RepID=Q8THH7_METAC  E=3e-08 s/c=0.49 id=24% cov=43%
--------------------------------------TVLIGRKTYEQVLdfgvWPYGEKKTYVFTRQKEplrREKNVEfVSGNVGEFVRRLKEntDENIWLVGGSQLIRVFLE------------------------------------------------------
>UniRef50_A6WBG8(44-172:212) Bifunctional deaminase-reductase domain protein n=3 Tax=Actinomycetales RepID=A6WBG8_KINRD  E=3e-08 s/c=0.46 id=39% cov=48%
--------------------------------------ALVMGRGTYEKVltfdAWPYPGRTVFLLSRRaePGVDDRVRVVRDVAEAVDAISacGARRVYVDGG-QVVQSFLAagLVQEITITTV--------------------------------------------
>UniRef50_D1AII1(7-138:188) Bifunctional deaminase-reductase domain protein n=1 Tax=Sebaldella termitidis ATCC 33386 RepID=D1AII1_SEBTE  E=5e-08 s/c=0.45 id=22% cov=43%
--------------------------------------TIIMGRKTYDQIltfgEWVYKGKDTYVLTSDisrvPEKPNIEFRNDEIEDLTTELKQKSKsnIWLLGGAETVNAFLE------------------------------------------------------
>UniRef50_A8MEI1(6-133:175) Bifunctional deaminase-reductase domain protein n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MEI1_ALKOO  E=1e-07 s/c=0.45 id=20% cov=48%
--------------------------------------TIMMGRTTYDWLMahedvFPYKDKACYIFSRAPreDTEYVTFVNKDIVSFSKELknKNGKNIWLMGGSELISDFIleKLVDEVIVT----------------------------------------------
>UniRef50_C4DTA1(11-134:176) Dihydrofolate reductase n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DTA1_9ACTO  E=5e-07 s/c=0.45 id=26% cov=48%
--------SLDGNIARlDDDLDWLTSrgeqaGDMGFFEFLDSVDAVAMGRNTYDKVigfgeeNWPFGDRHVGVLSTTlpEDADPRVTVYRDLDDLVA----------------------------------------------------------------------------
>UniRef50_C0YTM6(3-125:174) Putative uncharacterized protein n=1 Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YTM6_9FLAO  E=2e-06 s/c=0.44 id=26% cov=68%
-VTVIANISANGriLIADNphHQLP---PEAMEFYVQFVrQVGNIVIGLKTFENFlkfpkevKELFKGVEIIILSDKPYTVDGYKTVSSPEEAVEYMsgKDVQEIAIGGGAGTFNAFIdkDLVTDIY------------------------------------------------
>UniRef50_B8H7J6(4-145:183) Bifunctional deaminase-reductase domain protein n=1 Tax=Arthrobacter chlorophenolicus A6 RepID=B8H7J6_ARTCA  E=6e-06 s/c=0.37 id=25% cov=48%
---------------------------------------IVMGGETYAWLmehepgKWPYPSTPCYVFTHHEHAAppgsDITFVRGSVTEFaddFRADAAGRNIWVVGGGNLAAQFAAagLLDEIILSVI--------------------------------------------
>UniRef50_Q1WLC4(4-126:143) Probable dihydrofolate reductase FolA n=1 Tax=Sinorhizobium meliloti RepID=Q1WLC4_RHIME  E=3e-05 s/c=0.40 id=25% cov=41%
ILGYIAASLDGRVVSGDDSLEWLYKyddmdlgeHDYRLFLKRI--RTVVMGRGTYDFLakeqsPWAYGDQRVIVVTSRP---------------------------------------------------------------------------------------------
>UniRef50_C8P194(5-124:176) Dihydrofolate reductase family protein n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8P194_ERYRH  E=6e-05 s/c=0.41 id=23% cov=39%
--------------------------------------TVVMGRKTYKQVTEelspdvyPYEDSFTYVVSSQDIKPRNnmALISEDVIGVLNEIKQQEgkDIWIVGGGML------------------------------------------------------------
>UniRef50_D2BAP6(63-147:190) RibD domain protein n=2 Tax=Actinomycetales RepID=D2BAP6_STRRD   E=8e-05 s/c=0.57 id=31% cov=47%
--------------------------------------TLVMGRGTYEpaldaSITSPYSHLRQYVVSSTLTIDDPTVQVEtgDPIELIRRLKAEDtgmDIYLCGGGRLAASLLPEIDEIIL-----------------------------------------------
>UniRef50_C6Y1C3(4-135:178) Bifunctional deaminase-reductase domain protein n=2 Tax=Sphingobacteriales RepID=C6Y1C3_PEDHD  E=8e-05 s/c=0.37 id=14% cov=31%
-----------------------------------------------------------------KSVKEGAELIagDSIAEAGRiKAQPGKDIWLFGGASLTDALMKegLVDELWMS----------------------------------------------
>UniRef50_A4XB60(63-147:195) Bifunctional deaminase-reductase domain protein n=9 Tax=Bacteria RepID=A4XB60_SALTO  E=0.0001 s/c=0.56 id=29% cov=47%
--------------------------------------TVLMGRATYEpglTLGYtsPYDHLKQYVFSRslTPASHPDVEIVSGDPTAFvrqLRARPGRDIWLCGGGQLAGQLLDEIDELVL-----------------------------------------------
>UniRef50_A9BU31(21-154:207) Bifunctional deaminase-reductase domain protein n=2 Tax=Proteobacteria RepID=A9BU31_DELAS  E=0.0004 s/c=0.35 id=35% cov=27%
------ATSVDGFIARpDGSLDW-LPAggdggeDYGYAAFMRTVDGIVMGRSTYES--------------------------------------------------------------------------------------------------------------
>UniRef50_B9MJF3(8-139:193) Bifunctional deaminase-reductase domain protein n=11 Tax=Bacteria RepID=B9MJF3_DIAST  E=0.0004 s/c=0.35 id=26% cov=26%
--------------------------------------------------------------SRRLPGIDGADIrfvqgdVRPVHAAMRLAAGTKNLWVVGGGDLAGQF--------------------------------------------------------
>UniRef50_A1U3D7(4-167:171) Dihydrofolate reductase n=6 Tax=Gammaproteobacteria RepID=A1U3D7_MARAV  E=2e-50 s/c=1.21 id=43% cov=99%
--ALIVAMARNRVIGRNNKLPWYLPGDLRYFKQATMGKPIIMGRKTWDSIGRPLPGRMNVVISRNpeWQAPAGTVAAASLNEALvkaeaqANLEGGDEVMIIGGGQIYAEALPMVDRIYITQVHAEVDGDAFFPEVNWDEWEEIGREDFSASDNNPYDYSFVVYQR-
>UniRef50_Q3K556(7-169:170) Dihydrofolate reductase n=8 Tax=Bacteria RepID=Q3K556_PSEPF   E=4e-47 s/c=1.15 id=45% cov=99%
-LSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNIVVSRQAGLVlEGAEVYPSLEAAVVRAEEwakdqgVDELMLIGGAQLYAQGLAQADRLYLTRVALSPEGDAWFPEFDLNQWKLVSNVPNPA-EGDKPAYNFEVWEK-
>UniRef50_C0YTZ2(1-160:165) Possible dihydrofolate reductase type I involved in trimethoprim resistance n=1 Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YTZ2_9FLAO  E=7e-47 s/c=1.18 id=38% cov=100%
MTTIVVAMGEKNEIGFENQLLWHLPKDLKHFKEITSGHPVIMGRKTYESIGKALPNRTNIVVSRKKDWfEEGILIVGSIKEALKFAKKiDEEVFVIGGGNIYEQTMDVVDRLEVTLVKADLEADTFFPKIDPKIWKMTNEICHEKDEKNGYDFCFQTFER-
>UniRef50_A1VQZ7(6-163:166) Dihydrofolate reductase n=9 Tax=Bacteria RepID=A1VQZ7_POLNA   E=2e-46 s/c=1.18 id=40% cov=97%
-INLIYARAANGVIGRNNAMPWHLPEDLAHFKRLTQGWPVIMGRKTWDSLPprfRPLPGRTNLVITRQPDWQaPGALPAASLADALAQCSQSEEVWVIGGAQIYAHAEPLADRIEVTEIAQDFDGDAFAPPLG-EEWQETAREAH--VSSHGLPFSFVTFEK-
>UniRef50_Q5WDS2(1-159:162) Dihydrofolate reductase n=3 Tax=Bacillus RepID=Q5WDS2_BACSK   E=2e-46 s/c=1.17 id=32% cov=100%
MIVFVYARDAHYGIGKDNGLPWHLPADLRHFKRTTTGQTIVMGRKTFDSMGGPLPNRKNVVLTRSRSFQaEGAEVIHSLDDVLQLSKQ-EAIYVIGGAEIFALLWDICDKHIVTVIDEKFEADTFVPPLSEQEWELVETVPGPIDEKNRYPHEYRTYVRK
>UniRef50_A2U3M8(1-161:164) Dihydrofolate reductase n=2 Tax=Polaribacter RepID=A2U3M8_9FLAO   E=3e-46 s/c=1.16 id=38% cov=100%
MITIIAAIAKNNALGKNNDLIWHLPADLKRFKKVTTGHHILMGRNTFESIGRPLPNRITIIITKNEEYvQEGCLIANSVEQALEMAHDDDQIFIIGGAQVYEYAMkhDFADALDITLVHHEFEADVYFPEIDPTVWRRVEREDFIADEKNKFDYSFIRYKK-
>UniRef50_Q21NW4(3-171:171) Dihydrofolate reductase n=3 Tax=Bacteria RepID=Q21NW4_SACD2   E=3e-46 s/c=1.09 id=39% cov=100%
-LVIVVAAAQNGVIGINNTLPWRISADLQHFKQVTIGHPIIMGRKTYDSIGKPLPGRTTIVVTRQADwqaegYEDQVKVAYSLEGAMELAEqiaaqmGVAEAMLVGGAQLYRQALERVSKVHLTRVHAEIEGDAWFPELDGNIWAEVQCVRYKADEKNEYDYSFVELHRR
>UniRef50_C1XJD1(5-160:171) Dihydrofolate reductase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XJD1_MEIRU  E=5e-46 s/c=1.18 id=40% cov=97%
-IAFVVAMDQNRAIGRAGTLPWHLPDDLKRFRALTLGKTVLMGRKTFESIGRPLPKRRNVVLTRDPaFAAEGVEVVHTLEDALKL---DDELMVIGGGEIYTLFLPLVTHLHLTLVETVVpDADAFFPPWNPTGWRETYREHHPADERHPWAFTYLDLER-
>UniRef50_C0XLT5(1-160:162) Dihydrofolate reductase n=3 Tax=Lactobacillus RepID=C0XLT5_LACHI   E=6e-46 s/c=1.15 id=36% cov=100%
MISYIWAEDENGLIGASGNLPWHLPDDMAFFKKTTMGHPIISGARTFRSYNRPLPGRQNIVLSRHGDFPDGVLVISSVEQLCELVDKNPKenYFVTGGANLFGQLLDKVDRLYRTKIHHQFTGDTYMPEIKYAQFNQVTSIDGIVDERNRYPHTFEVFER-
>UniRef50_C5CTW3(10-171:177) Dihydrofolate reductase n=1 Tax=Variovorax paradoxus S110 RepID=C5CTW3_VARPS  E=7e-46 s/c=1.14 id=40% cov=99%
-IHLIFARAANGVIGAKGTIPWHLPEDMVHFKQQTAGAPVVMGRKTWDSLPprfRPLPGRRNIVVTRQDDWkAEGAWRVGSLQEALALCEEsqVPDVWIIGGAQIYAEAEPLAQQVVVTELAHDYEGDAHAPELSPSAWRETKREAH-VSAKEGLNYSFVTYER-
>UniRef50_Q134B2(12-175:179) Dihydrofolate reductase n=10 Tax=Bradyrhizobiaceae RepID=Q134B2_RHOPS  E=2e-44 s/c=1.09 id=41% cov=99%
-IVIIVAVAENGVIGEGNAIPWRLKSDQRRFKQLTLNKPVIMGRKTYQSIGRPLPGRTNIVVTRDTHFQaAGVVVAPSFEAAERVAAGDamrrsaTEVVVVGGSEIYAHWLPRATCIELTEVHASPQGDTTFPAIDPDQWEEVARTRHGAGPEDSVEFSYVTYRR-
>UniRef50_B8F4S8(3-161:165) Dihydrofolate reductase n=5 Tax=Pasteurellaceae RepID=B8F4S8_HAEPS   E=3e-44 s/c=1.13 id=47% cov=99%
-ISVIVARTLNKVIGKDNAMLWHLPVDLAWFRENTLGKPVIMGRKTYESIGRLLPKRPNIILSRSGFAIDGAYSAISLEQAVELAKnfaNSDEIMILGGGELFKQTMPFADKLYLTEIQANIEGDTFF-EFDETQWQQIAEKWSEIDEQNSYRCRFMILDK-
>UniRef50_C6W5S3(20-180:183) Dihydrofolate reductase n=1 Tax=Dyadobacter fermentans DSM 18053 RepID=C6W5S3_DYAFD  E=4e-44 s/c=1.11 id=38% cov=100%
-ISIIVAAAENGAIGRDNQLLWRLSDDLKRFKQLTLGHPMIMGRKTFESIGKPLPGRTSIVITRNANFAfDGVVVVHSLDEALEKAKEIDsqEVCIVGGGEIYEQSQAIATHIYLTKVHTSVVGDTFFSIREPEAWTETERISHEPDERHIFPFEFINYIKK
>UniRef50_C6XMY9(15-180:182) Dihydrofolate reductase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XMY9_HIRBI  E=4e-44 s/c=1.07 id=42% cov=100%
-LAMIVARAKNGVIGVDGDLPWRLKGDLKFFKSVTLGKPVIMGRKTWESLPfKPLKGRANLVVSRRHDFDAqGARVFPSLGVAIAAgraiadQTDVEEVMIIGGGAIYTAAFENVDVLYVTEVNTEPEGDTFFPEIDDDVWTCVEETNHAADEDNDHAFVMRKLVRK
>UniRef50_C6W102(7-166:167) Dihydrofolate reductase n=1 Tax=Dyadobacter fermentans DSM 18053 RepID=C6W102_DYAFD  E=4e-44 s/c=1.11 id=38% cov=100%
-LSIIAAMSENHVIGLNNSLPWHLPDEWAHFRKVTAGKAFIMGRKSFEAPDALHSEYRNVIITSRPpaQAEPRVEYARDISGAIALLSDETDVFVLGGASVFEQMLPLADRMYLTIVHAQVEGDAFFPAFDSDDWQLADSEFHGADDDHAYAFSMNLYIRK
>UniRef50_C4FSY3(1-162:169) Putative uncharacterized protein n=1 Tax=Catonella morbi ATCC 51271 RepID=C4FSY3_9FIRM  E=5e-44 s/c=1.10 id=37% cov=101%
MLTLVYAQDQAGGIGYQNQLPWHLPNDLKFFKQVTLGHAILMGRKTFESMGcRLLPGRTSYVLTRQEDYKSEIEGLHRVHnlEAIKALAEDQEVMVIGGAEIFAALLPLADRVIRTQIKATFPADTFVADLDQDQWQCVEIQEGLVDDKNQYAHQFEWWVRR
>UniRef50_Q03S94(1-162:163) Dihydrofolate reductase n=4 Tax=Lactobacillus RepID=Q03S94_LACBA   E=5e-43 s/c=1.08 id=34% cov=100%
MLIFLWAESQGRVIGLHGGLPWHLPADMHYFKTVTTGHTIVAGSKTFASFPRPLPNRKNIVVSHQPATafPENVSVLHSLPAvrAYAAARPQEKIFVVGGAQLFAGLLDDVDFLYRTRIDAGFDGDTWMPVIDYSQFTLIDQQPGIRNEKNPYDFVFEQYQR-
>UniRef50_C1IBP0(1-158:161) Dihydrofolate reductase n=1 Tax=Clostridium sp. 7_2_43FAA RepID=C1IBP0_9CLOT  E=6e-43 s/c=1.10 id=37% cov=99%
MISLIVAMDKNNGIGNKNKLLAHISEDLRYFKRVTDGNTIVMGYNTYMSLPkRPLPNRRNIVLTTKDIKLEGAVVVNSIEELLKLLNTEEETFICGGSSIYNQMLPYADKLYITHIFDEFEADTYFPEI-TDEWEISESFCHKENINHKHPHIFTIYTK-
>UniRef50_D1QNC5(2-160:160) Dihydrofolate reductase n=1 Tax=Prevotella oris F0302 RepID=D1QNC5_9BACT  E=1e-42 s/c=1.09 id=41% cov=99%
ILSLIAAVARNRAIGYQNRLLFHIKTDLEHFKRLTMGHVVIMGRHTFESLPnGALPHRKNIVISKSVASFHGCTRVSSFKEALDMCQTEEEVFVIGGEQVYKEAITQADRLYLTEIDALAEqADAYFP--DYNSWHLVAHEAHKKSEDNPFAFAFTVYQRR
>UniRef50_B6INW3(24-189:190) Dihydrofolate reductase n=4 Tax=Alphaproteobacteria RepID=B6INW3_RHOCS  E=2e-42 s/c=1.04 id=43% cov=100%
-LVLVAAVARNGVIGRGNTLPWRLPGDLRFFKRTTMGKPVVMGRRTWESIGaKPLPGRCNIVLTRDTGFaPEGAIVCHGFLGAIAEARsvaartGAPEVCVIGGESLFAEALRMADRLYLTEVLAEPAGDVLFPPFDRGAWMQTELERADAAGPDSPAYRILRLDRK
>UniRef50_A7IF75(11-175:178) Dihydrofolate reductase n=3 Tax=Rhizobiales RepID=A7IF75_XANP2   E=2e-42 s/c=1.05 id=35% cov=99%
-LALVVAVSQNGVIGTDGGLPWRLPSDLKRFRALTWGKPLLMGRRTYESIGRPLPGRTSVVVSTDPAFtvPEGVLKGASLEDGLRLADEaadamgADEIMVIGGARLFHDTLPLARTLHLTQVHAAPDGDVFFPAFDEAQWREIARDGPIQGEKDEAAFTALTLVR-
>UniRef50_B2TR57(1-162:164) Dihydrofolate reductase n=10 Tax=Clostridium RepID=B2TR57_CLOBB   E=4e-42 s/c=1.06 id=36% cov=100%
MLSIIVAIAKNNVIGNDNKLIWHISEDLKRFKEITSGKTIVMGRKTFESLPGVLPNRKHIILTRDKNFKvnsECVEIIYDFDELLNKYKNsDDEVFIIGGGEIYKQLLPYSNKLYLTKINKDFDGDTYFPQINYNDFKIDYESDVITDEKSGLEYKFINLSR-
>UniRef50_A6L1Q7(3-162:164) Dihydrofolate reductase n=34 Tax=Bacteroidales RepID=A6L1Q7_BACV8   E=5e-42 s/c=1.07 id=36% cov=99%
-ISIIVAIARNHGIGFENKLLYWLPNDLKRFKALTTGHTIIMGRKTFESLPKgALPNRRNIVLSRREGAVfAGAECFPALEIALSHCKEEEEIFIIGGASLYKEAMHIAQQLYITFIdDTSKEADAYFPEIKKEEWKETGREDHPTDEKHLYPYSFINYSR-
>UniRef50_C8NE93(1-161:169) Dihydrofolate reductase n=24 Tax=Lactobacillales RepID=C8NE93_9LACT   E=6e-42 s/c=1.06 id=35% cov=100%
MLIYIWAQDERGLVGKDGTLPWRLPNDLKFFKEVTMGQTILMGRKTFEGMGsRLLPGRQTIILTTSSDYIvPGAEVVTNIEE-IVEDSRHEDIYVCGGAQVYNLLKNHVELLYCTRIHASFEGDSYFPtEFPWHDFIKVKSLEGEIDEKNLYPHTFEIYERK
>UniRef50_A6GQA5(3-185:188) Dihydrofolate reductase n=1 Tax=Limnobacter sp. MED105 RepID=A6GQA5_9BURK  E=6e-42 s/c=0.93 id=36% cov=99%
-VSIVAAVAENGIIGINNSLPWHLPEDLAFFKQTTLGCPVLMGRKTYESINRPLPGRLNVVLSSNSDWKPapgkdgtprsvithpaalpegsatQIATATNLPDALNWLSSFEQVFLIGGSNLYEQALAqgLVDELILTEIHQSFEGDASFPQWDRQQFREVDRITNTATPERAWGFDFVKYAK-
>UniRef50_UPI0001C37DF3(1-156:160) dihydrofolate reductase n=1 Tax=Ruminococcus flavefaciens FD-1 RepID=UPI0001C37DF3  E=1e-41 s/c=1.09 id=39% cov=97%
MISIIAAAAKNGVIGAGGKIPWDIPEDMAYFRRITYGGAVIMGRRTYEDIGRPLPGRFNVVVSAKMQTaPEGTALAHSLAEAVEIAGNSgrENIFLCGGAAVYREGLAFADRIYLTILDKEYSGDVYFPEFSEKEFRLTSYERCDSA-----PITFCIYDK-
>UniRef50_Q03F97(1-160:161) Dihydrofolate reductase n=2 Tax=Pediococcus RepID=Q03F97_PEDPA   E=1e-41 s/c=1.06 id=35% cov=99%
MISMIWAEDLRHGIGKQQSIPWHIPGDMAFFKKTTSGNTVVMGRKTFDSIGKALPNRKNIVLSHHPTSLPDSVVgVGSLSElqAIFETHPNEKFYIIGGSHLYNALLSQADELLITRIQKDYQCEVLAPDITQNEFKLASSVEHESTERNP-AYTFETWIR-
>UniRef50_B6YRF0(3-162:164) Dihydrofolate reductase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRF0_AZOPC  E=3e-41 s/c=1.06 id=35% cov=99%
-LSIIASLGRNNEIGKENRLLCYLPADLKHFRKITLGHSIIMGRKTFDSLPnGILPDRENIIISRNGSLAiKNARVYTSLDFALSKLMNEEEVFIIGGAQIYQQTLPIVNNLYLTKVYATFpEADVFFPLINYSEWHETEQEKIPANTKNPYPISFTKYER-
>UniRef50_B9LR90(21-191:194) Dihydrofolate reductase region n=2 Tax=Halobacteriaceae RepID=B9LR90_HALLT  E=4e-41 s/c=0.99 id=42% cov=99%
-LVLVAAVAENRVIGDDGGMPWHYPADLARFKRLTTGHPVIVGRATYESiadrIGGPLPDRTSVVLtTRDLDLPEGAVVANDLDEAVDLAGadaadrGVDDVYVIGGATVYEQFLDRADRMVLTEVPEQPDGDTRFPDWDDEEWVETEREVVGADGERGgeaDALAFVTYER-
>UniRef50_B2SDZ8(15-176:180) Dihydrofolate reductase n=19 Tax=Francisella RepID=B2SDZ8_FRATM   E=5e-41 s/c=1.04 id=38% cov=100%
MISLIVAYDKNFGIGKENTLAWKLSEDLKNFKKITENNYIVMGRKTFESIGRPLPNRKNIILTRDKDYkQDKCLIINSTQDILnfAESKPHYEIFIIGGAQIYKEFLKYADRLYITEVDAEMtDLDAFFPQWDKSKYKRIGHKQFKKDDKNEFDFTFSVFEK-
>UniRef50_Q3BX85(3-164:164) Dihydrofolate reductase n=6 Tax=Xanthomonas RepID=Q3BX85_XANC5   E=1e-40 s/c=1.03 id=43% cov=100%
-LTLIVAFDRNNAIGRDNELPWKLPDDLKRFKALTLGKPILMGRKTAQSLGRALPGRLNLVLTRSGQVPfDGMQAVASVEQAIERAvqEGAQELCVIGGGEVYRLTMERADLLAVTEVDTAVDGaDTHFPPIDPAVWSPARRELHAADARHAHAFSFVDYERR
>UniRef50_Q0AN20(8-172:173) Dihydrofolate reductase n=4 Tax=Alphaproteobacteria RepID=Q0AN20_MARMM  E=1e-40 s/c=1.01 id=38% cov=99%
-LVLVVARGMNGVIGVDGDLPWRLSSDLRNFKAITSGKPIIMGRKTWESLPrRPLPGRLNIVVTRQDGYvAEGGHVAGDLGEAMDAafmradADGVDEVCVIGGAQIYAATLERADRLYLTEVEAAPEGETCLPEIDEALWRETRRELYPAGPGDDHAFMLRVLDR-
>UniRef50_Q38WX9(1-163:166) Dihydrofolate reductase n=5 Tax=Lactobacillales RepID=Q38WX9_LACSS   E=2e-40 s/c=1.02 id=33% cov=100%
MIAFLWAEDQNGLIGQDGHLPWRLPNDLANFKRETINEAVIMGRKTYDSLPkKPLPGRQNIVITRQSGLtvAKDVLVFNERTQLLDYQKEHPmqKLFIIGGADIFKLFAADVDYLYVTKIAEKFKGDVYMPTIDYTQFKLISQKAGAVDERNQYPHTFEIYQR-
>UniRef50_Q1LSS4(2-161:165) Dihydrofolate reductase n=1 Tax=Baumannia cicadellinicola str. Hc (Homalodisca coagulata) RepID=Q1LSS4_BAUCH  E=3e-40 s/c=1.04 id=50% cov=100%
IISLIAAMTVDRIIGIKNTMPWHLYDDLIWFKKHTNNKPVIMGRKTFDAIKKPLSGRLNIVLSRNFipSRDQDIIWVDNPIKALIAAGNVTEVMVIGGAQIYNIFILQAHRLYLTHIDINIKGDTWFPHYHTNQWRVTFRKYHNDQEKNLPRYYFEILER-
>UniRef50_B2ICT5(25-189:198) Dihydrofolate reductase n=2 Tax=Beijerinckiaceae RepID=B2ICT5_BEII9   E=4e-40 s/c=1.00 id=36% cov=100%
-LTIVAALADNRVIGLNQAMPWDLPGDRRHFRERTWGKPMLMGRKTFESIGRALPGRETIVLTRDETFaAPGVLVAHDLEGALGLAHDWARIMgaktiiLVGGGELFAALLPRVERLELTLVEGNPKGDTFFPPIDWSQWEEEKRSGPLQGPNDTISYQFVDYHRK
>UniRef50_C7NFY1(168-336:337) Dihydrofolate reductase n=3 Tax=Actinomycetales RepID=C7NFY1_KYTSD   E=6e-40 s/c=0.97 id=36% cov=94%
-LTLVVAVARNGAIGRDGDLPWHLPGDLKHFKDTTMGGTMVMGRRTFESFPRPLPGRRHVVMTSDPTWLPGgpavegdpasgarfdeVLVARSWAEALLMAGDG-EVFVVGGAGVFADALPVADRLVLTEVDQSPqDADTFFPitwPVDPTVWHESSRTPGEG-------YAIVEYRR-
>UniRef50_C8WCM1(7-165:165) Dihydrofolate reductase region n=4 Tax=Zymomonas mobilis RepID=C8WCM1_ZYMMN  E=7e-40 s/c=1.03 id=36% cov=99%
-IMLIFARAQNGVIGKDNTMPWHISADLKHFKALTLGHPMIMGRRTFESLPGLLPKRPHIVLTHNHHWQaEGAEVVCDLEEAIKAARKYsSQIAVIGGANIFQQFWDKADRIELTEIYRDYSGDTFVDLPDMNHFSLVGQEDFKAEGECP-AFSFKSFLRK
>UniRef50_A0Z2N0(13-176:184) Dihydrofolate reductase n=2 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=A0Z2N0_9GAMM  E=8e-40 s/c=1.00 id=37% cov=99%
-VVLVLAVSENGVIGRGNALPWDLPDDLQHFKKATMGCPILMGRKTFESVGRPLPGRTNLVLTRDSTWQaPGVTIFSSVDKalalaeAQALIDGASAVCVVGGAEIYRLCLPRADRILLTLVHGDVSGDATFDLSVLETWQEQRREHFPKGARNSHDFSVVEFVR-
>UniRef50_C6XGC7(6-169:176) Dihydrofolate reductase protein n=1 Tax=Candidatus Liberibacter asiaticus str. psy62 RepID=C6XGC7_LIBAP  E=9e-40 s/c=1.00 id=37% cov=99%
-IILIAAITRNNVIGSCGGMPWKISSDLKRFKSLTTGNPVVMGYRTFQSIGRLLPGRTNIIITRDNtrraSVNPEAVLASSILDSLDLASktGSKKIFIIGGGEIYAQTISLAHTLYITHIEKEIEGDVFFPSIDSNIWKKQEKEIItSAGEGDDYPTRFVIYDR-
>UniRef50_C9MLK6(3-161:161) Dihydrofolate reductase n=2 Tax=Prevotella RepID=C9MLK6_9BACT   E=1e-39 s/c=1.03 id=35% cov=99%
-LNIIAAVAANRAIGYRNDMVYFIREDLKRFKQLTTGHTVIMGRKTFHSLPKgALPNRRNIVLSRTEKDFKGCEVYPSLDEAMRHIHADEQAFIIGGASLYKEALGIANRLYLTEIaDTPAQADVFFPPYNDGTWRVESREEHPATDDTP-PYSFVNYVRK
>UniRef50_A4VUL2(5-168:170) Dihydrofolate reductase n=9 Tax=Streptococcus RepID=A4VUL2_STRSY   E=1e-39 s/c=0.99 id=31% cov=100%
-IVAIWAQDENGLIGKGDRLPWSLPADLAHFKKTTTGHTMVMGRITFDGMGkRALPNRHTIVLTTDKTYQlesERITILHSVEDVLDWYnKQEQTLFVIGGGQIFTAFAPYIETLIVTDIHGQFNGDVYFPKaFPMEKFQLQSANLRPKDEKNPYDFTIKTYERR
>UniRef50_C2MBL2(3-165:173) Dihydrofolate reductase n=1 Tax=Porphyromonas uenonis 60-3 RepID=C2MBL2_9PORP  E=5e-39 s/c=0.99 id=38% cov=99%
-IWIIVATARDRAIGRDGTMPWRLKDDLRRLKATTTGHAVIMGRHTWDSIGaRPLPNRYNIVVSRTlpEGDAETHYVASTLEQALQHCQqaGYDRVYIMGGGVLYKSGLPYATHLNLTMVDTVVpDADTHFPEINLSEWSKLEEAHYPADERNDYPVTQTLYKR-
>UniRef50_B8HHJ9(7-174:181) Dihydrofolate reductase n=2 Tax=Micrococcineae RepID=B8HHJ9_ARTCA   E=8e-39 s/c=0.96 id=41% cov=99%
VIGMIWAQASNGVIGRDGTMPWHLPEDFEHFRRTTEGHSVIMGRRTWESLPepfRPLPGRRNLVITSDPAWsAPGAVRSSSILNALAAAAGQPgsdQVWIIGGGMVYREalFLRAANTAVITLIASDIDGDTYAPELGPD-WEMASAEPgvGWTTAANGTRYRIETWTR-
>UniRef50_Q9U8B8(6-184:185) Dihydrofolate reductase n=1 Tax=Heliothis virescens RepID=DYR_HELVI   E=2e-38 s/c=0.89 id=34% cov=99%
-LNLIAAACDNMGIGVNGALPWRLKKEMAYFTTMtskvsepTKVNAVIMGRRTWDCIPdkyRPLQDRVNIVLTHNVDSvkenvPEGVMVFPGLDEAIKYIEGREDIestWVIGGSSIYRAAMthPNCGKIYLTEIQKSFDCDTFFPNIDKQQFHLVDEEqiPGEKQVEGNISYYFRVYKK-
>UniRef50_Q54801(5-166:168) Dihydrofolate reductase n=65 Tax=Streptococcus RepID=DYR_STRPN   E=2e-38 s/c=0.98 id=36% cov=100%
-IVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGrRLLPKRETLILTRNPEEKiDGVATFQDVQSVLDWYQaQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPeELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRK
>UniRef50_P00380(1-162:167) Dihydrofolate reductase n=1 Tax=Enterococcus faecium RepID=DYR_ENTFC  E=3e-38 s/c=0.98 id=32% cov=100%
MFISMWAQDKNGLIGKDGLLPWRLPNDMRFFREHTMDKILVMGRKTYEGMGKLsLPYRHIIVLTTQKDFkvEKNAEVLHSIDELLAYAKDIPEdIYVSGGSRIFQALLPETKIIWRTLIDAEFEGDTFIGEIDFTSFELVEEHEGIVNQENQYPHRFQKWQK-
>UniRef50_Q5M5B2(5-164:167) Dihydrofolate reductase n=9 Tax=Streptococcus RepID=Q5M5B2_STRT2   E=4e-38 s/c=0.99 id=35% cov=99%
-IIAIWAEARNHVIGKNHTMPWHLPAELAHFKKTTMGSAILMGRVTFDGMNRRcLPGRETLILTRDKDFDcEEVTTVTSVEEALAWFEqQDKDLYIAGGASVYKAFDGHYDVLIKTTIEADLEGDTYFPQLDTTAFKEVSRNRVPKNEKNAYDFSISRYEK-
>UniRef50_D2LGH8(9-174:178) Dihydrofolate reductase n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LGH8_RHOVA  E=4e-38 s/c=0.95 id=34% cov=99%
-LALVVAAAENDVIGREGKLPWRLKSDLKRFRRLTMGHPLIMGRKTFASIGKPLDGRDSVIVTRDaasVSPQPGVFVATSIKDALDiararaAERRVAEAFVIGGAEIFALALPYADRIHLARVHASPSGDAYWQAPPAEEWQVVSREEWPANQTDEFSVTDLVLER-
>UniRef50_B1MYC2(4-165:166) Dihydrofolate reductase n=3 Tax=Leuconostoc RepID=B1MYC2_LEUCK   E=5e-38 s/c=0.98 id=35% cov=100%
-IRMVWAEDSTHAIGKNGQLAWHLPDDLKLFKAETMNTLMVMGRTTWDTIGRPLPGRTSLVLTHQKDFKtpyDDVIIAHSVDEVLDYIeKETRDISIAGGAAIYHAFMPYATDLIVTRIDVTIAGDTFVDAIDLSQFKLVSATAHDKDDKHDYSFVVERYERQ
>UniRef50_C4Z3U6(1-156:157) Dihydrofolate reductase n=8 Tax=Firmicutes RepID=C4Z3U6_EUBE2   E=6e-38 s/c=1.01 id=34% cov=97%
MIGLIVARSKNNVIGRNGEIPWKIKGEQKFFKELTIGNIVVMGRKSYEEIGHPLPNRQNIIVSKTMKYEgENLITVSSLAEALA-LSDNSNIYIAGGYGVYKEAIPFVDVMYITEVDMNIEdGDVFFPEFDVNDFDLIIGETFGENTK----YTRTTYIRK
>UniRef50_C7H0N2(1-161:162) Dihydrofolate reductase n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H0N2_9FIRM  E=8e-38 s/c=0.98 id=32% cov=97%
----IVVVDKNWCIGKDGGLLVHLSKDLKYFKEKTIGKTLIVGRKTLESFPggKPLPGRKTIVLTRNTSYkAEGAYVCHSKQEVLEKVKDlhPADVFVAGGGAIYKQFLNDVDKGFVTKICNEYSGDTFFPNLDEDE-DFALESEGETIEENGVKFKFCIYNR-
>UniRef50_C2HC06(1-162:172) Dihydrofolate reductase n=11 Tax=Enterococcus faecium RepID=C2HC06_ENTFC  E=1e-37 s/c=0.97 id=31% cov=100%
MFISMWAQDRNGLIGKNGLLPWRLPNDMRFFREHTMDRILVMGRKTYEGMGDLsLPYRHIIVLTTQPNfrTKENAEVMHSIDELLAYSQTIsEDIYVSGGSRIFQELLPYTGRIWRTLIDSTFEGDTYIGDIDFSDFALIEEYEGITDQENLYAHRFQKWER-
>UniRef50_C5CC92(11-185:186) Dihydrofolate reductase n=3 Tax=Actinobacteria (class) RepID=C5CC92_MICLC  E=4e-37 s/c=0.89 id=39% cov=99%
VIAMIWAQTPGRVIGRDGTMPWHVPEDLAHFRAHTHGHPVIMGRRTWESFParfRPLPGRTNIVVSRTLTATEqagaqlraaGAVVVPDFgaaLAAAAEADGCDTVWVIGGATLYDQALDVASRAEVTVIDADVDGDTHAPPLD-ARWRRTAVDPAPdawLDSASGPRHRFERWER-
>UniRef50_Q8D3H9(3-161:162) FolA protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D3H9_WIGBR  E=5e-37 s/c=0.97 id=44% cov=99%
-ISLIWAQSKNKVIGHDQYIPWNLPEDISWFKKNTINKPVIMGRKTFESIKKPLENRINIVLSKNLYRNvmSNLKIAKNPKQALFFAKNYNEVMIIGGKQIYKIFLPKATKLYLTVINAEINGNIFFPRYNRKKWILSFEKYFNSDTKNKYSMYFRIFNK-
>UniRef50_B0MRL8(1-159:161) Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MRL8_9FIRM  E=1e-36 s/c=0.96 id=32% cov=97%
---IIVAVDENYGIGKDGDLLAHLSPDLKRLKAMTVGNIIVMGSKTYMSFPkRPLPDRENLIITHHPENYPGIKCFTGVDEFLEYSKTADKpIFVLGGGSVYEQLLPYCEKAHITKILHSFEADTFFPNLDNNpDWEKENEEDIVTGEK--YPFRYVTYVRR
>UniRef50_B2UP70(10-156:159) Dihydrofolate reductase n=1 Tax=Akkermansia muciniphila ATCC BAA-835 RepID=B2UP70_AKKM8  E=2e-36 s/c=1.04 id=40% cov=92%
----VVAMAPDRGIGYRGALPWHLPDDLKTFKRITTGHPVLMGRKTYESIGRPLPGRQNIVLTRDPaWTAEGVQVVHSAGELECLELMDPEIMVIGGAEIFSLMMPAMSRMWVSKVKGEYPADTFLPPFENRLERAVLKEHFE-------DFDLYLYE--
>UniRef50_A3K5B9(1-139:153) Dihydrofolate reductase n=1 Tax=Sagittula stellata E-37 RepID=A3K5B9_9RHOB  E=2e-36 s/c=1.10 id=44% cov=85%
MITLIAAHDRNRAIGKDGDIPWHIPEDLAMFKRETLGGAIVMGRKTWESLPfKPLKDRLNIVVSRDTSLHE--HVVGSVEDAIALAqsQGYFRIYGIGGQRIYEAMLPLAHRLLITEVDTVVeEADAFFPDVGEG-WREVS----------------------
>UniRef50_Q494F1(2-163:164) Dihydrofolate reductase type I n=1 Tax=Candidatus Blochmannia pennsylvanicus str. BPEN RepID=Q494F1_BLOPB  E=2e-35 s/c=0.92 id=48% cov=100%
IISLIAALTTNHIIGKKNVIPWYLPIDIKWFKYHTLYKPIIMGRKTFESIGkKPLLNRLNIVLSRNlLNNYNGVFIAENIDEALSLIQDAYEVMVIGGSEIYNVFLPRAQRLYLTYIHnmVEIDGDILFPDYDIREWKSIFNSFYKVREDCFCYLHFSILER-
>UniRef50_B9DU71(5-165:165) Dihydrofolate reductase n=13 Tax=Streptococcus RepID=B9DU71_STRU0   E=2e-34 s/c=0.91 id=30% cov=100%
-IIAIWAEDENGVIGANGTLPWYLPKELQHFKNTTLNHAILMGRVTFEGMKrRLLPNRQTLVLTSDESYHvDGALTMTSLEKTLEWYHaQENNLYVIGGQKVLQTFDGHFNKIIKTVVHHQFDGDTYRPELDLSPFVEEDCFFYERDDQNPYDFTVHILVRK
>UniRef50_D2Q8R3(39-220:224) DfrA Dihydrofolate reductase n=12 Tax=Bifidobacterium RepID=D2Q8R3_9BIFI  E=2e-34 s/c=0.80 id=39% cov=99%
-VNLIWAQArdkegRDGAIGFEGGMPWRLPEDMKHFTELTVSHPVIMGRRTWEALSpkfRPLPNRDNIVISHDPAYsAPGATVVDTLDDALDLARQEaipddgldrSEIWIIGGAQVFRDALPFADKAYVTQISMHVDADTYAPDIaslaESGAWRMAEEGVWQGTQKGSDDiagFRFVTYEK-
>UniRef50_P00374(5-185:187) Dihydrofolate reductase n=50 Tax=root RepID=DYR_HUMAN   E=3e-34 s/c=0.81 id=31% cov=97%
----IVAVSQNMGIGKNGDLPWpPLRNEFRYFQRMTTtssvegkQNLVIMGKKTWFSIPeknRPLKGRINLVLSRELKEPPQGAHFlsRSLDDALklteqpELANKVDMVWIVGGSSVYKEAMNHPGhlKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGvlsDVQEEKGIKYKFEVYEK-
>UniRef50_UPI00015B4DEB(5-182:184) PREDICTED: similar to conserved hypothetical protein n=1 Tax=Nasonia vitripennis RepID=UPI00015B4DEB  E=4e-34 s/c=0.81 id=33% cov=99%
-LKLIAAACENMGIGVNGDLPWRLRKEMDFFTKMTsttkdenKKNVVLMGRRTWESIPkkfKPLSNRINMVLTSQPlDLGEDAIVCKNLPEAIEKIsqsplkDKVEQVWVIGGSLVYKTSMesPNFYRLYLTRVKKDFKCDAFFPEI-PNDYILVKdpEVPEGIQEEKDIKFEYEVYEKK
>UniRef50_P00381(1-162:163) Dihydrofolate reductase n=9 Tax=Lactobacillus RepID=DYR_LACCA   E=1e-33 s/c=0.89 id=28% cov=100%
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPkRPLPERTNVVLTHQEDYQAQGavvVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLAGSFEGDTKMIPLNWDDFTKVSSRTVE-DTNPALTHTYEVWQKK
>UniRef50_A4GI75(2-167:168) Dihydrofolate reductase n=1 Tax=uncultured marine bacterium HF10_29C11 RepID=A4GI75_9BACT  E=7e-33 s/c=0.85 id=32% cov=99%
MLKMILAMDLDGCIGKENGLPWRLQSDMLRFKRLTIGQgnsAVLMGRTTWETIPerfRPLVDRINIVVTRNRNYAlSDAHVTYSIENGIEHASNNncDECWIIGGADVYEQCRDLVDEIHLTSVETSNSGDIKVGMFG-DEWNREIIESTPESSDNEHPTTYMILRK-
>UniRef50_Q934V0(1-157:158) Putative dihydrofolate reductase n=1 Tax=Salmonella enterica subsp. enterica serovar Typhi RepID=Q934V0_SALTI  E=1e-32 s/c=0.89 id=38% cov=78%
-MKMIAAVGRNYEIGIGNELPWRCPTDLKLFKQLTKNATVVMGRKTMESLKRPLPERHNLVLTRSRGYIPNGFYPAGIDDVLRL---PDPVWVIGGGQIYSLFMPHVEEIWLSHIGVDVPGaDAFFPA--------------------------------
>UniRef50_UPI000180BE95(8-192:194) PREDICTED: similar to GJ10259 n=1 Tax=Ciona intestinalis RepID=UPI000180BE95  E=4e-31 s/c=0.73 id=31% cov=99%
-IHSVVACCNNGGIGFKGRLPWRLPKEMKYFKRITTGeveefggrrNVVIIGRKTWESIPksfKPLKDRINIVISRtlDKDCEGPDLVVNSLDELIDLlhskpwCDKINQVFNIGGNEIYKLIHNsqYCGKIYLTRVLADLQCDTFLENLD-DNFTKLPTEGFPevpqgiQMDKNDLQWKVEVYEKK
>UniRef50_C7P3D4(3-154:157) Dihydrofolate reductase region n=1 Tax=Halomicrobium mukohataei DSM 12286 RepID=C7P3D4_HALMD  E=1e-30 s/c=0.88 id=34% cov=94%
-IIAVAAVGENGVIGSGDELPWHLPHESRRYRERVADDTVVLGRKTFEMFEE-LPGARQLVLSRseRSFEAETATHAASVDAAIDLARErgDPVLYVLGGAGVYEAFLPRYDRMLLSRVDGEYEGDATFPAFDREAWTLVDETPYDG-------YTLETWE--
>UniRef50_A6DQ18(1-148:149) Dihydrofolate reductase region n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DQ18_9BACT  E=1e-30 s/c=0.91 id=32% cov=94%
MLSLISAMDKNGLIGTGKALPWKVEEEYQRYLDTVKGKKIIVGRKTFEISGLDLKDEQVHILSSRSQ---GTNYYNNIEDAIKACGE-NDIFVTGGAEVYKLAMPHADRLYISVIKGDYEGSIYFPNIDANIWEVQHHEELPE-------YDYYIYRKK
>UniRef50_D2NRG7(5-220:222) Dihydrofolate reductase n=2 Tax=Rothia mucilaginosa RepID=D2NRG7_9MICC  E=8e-30 s/c=0.61 id=39% cov=99%
-LGAIWAQTDAGIIGRAGDMPWYAPEDLAHFKKVTLGAPVIMGRRTWESFPprfRPLPGRTNIVISRSVTEAeerDGALWVPSLDAALYAARDavgapveatpadtatdapAVDAWIIGGGSVYAEALSRNDLPAFGRVKTvertlfycqegnEITGDTRAPELQLADshgncatgspngcWHVVSETAWEKSEkgylldesgtKNPMYFSFQRLER-
>UniRef50_Q28J42(11-190:197) Dihydrofolate reductase n=5 Tax=Euteleostomi RepID=Q28J42_XENTR   E=4e-29 s/c=0.72 id=26% cov=99%
-VKLIAAACNSMGIGLNGYLPWNLPNEFKYLLDTITRvtqpgkkNLLLWGRQSFETFDEsllPLPNCIIALLSRKLSTVPPYVsyLCKNEEEILKFAstpplnDEIETIWVLGGVESYKNLMqhPWCNHIYFTKIMADFECDTFFPEFDKNIFKLKENfpgVPSGIQEENGVKYVFQVYQR-
>UniRef50_C7YNN0(6-203:205) Predicted protein n=3 Tax=Sordariomyceta RepID=C7YNN0_NECH7   E=4e-29 s/c=0.65 id=35% cov=99%
-LTLIVAATRNMGIGAHGTMPWTgLRKEMRYFARVTTRippqsppaslNAVIMGRKTWDSIPvkfRPLKDRLNIIITRSAGPEDPTPIigdkepirVSSLEHALRYARartDVARVFVMGGAQIYAAALELseARRVLLTSIERDFDCDTFFPiELkgeKSGDWVKKPREElaswtgedisEDGEEEAGTKYEFQMWEK-
>UniRef50_Q6WEA8(5-181:182) Dihydrofolate reductase n=4 Tax=Hartmannella cantabrigiensis RepID=Q6WEA8_9EUKA  E=5e-29 s/c=0.72 id=32% cov=97%
--ALVVAVTKTMGIGNKGGLPWsSIRGDMNFLKKITsetkdaaKQNAVIMGRKTYVGIPakfRPLSNRVNIVISTNanlrkeESIPDSVHIVDSFDLAVTKAynlPNIENVFVIGGSSVYAEAMkhPQCKTIYYTNILTpDFTCDTFFPKIEENVFKVTSR--SDLQQEGETSYEFLTYYR-
>UniRef50_B0S098(2-164:164) Dihydrofolate reductase n=2 Tax=Finegoldia magna RepID=B0S098_FINM2   E=4e-28 s/c=0.77 id=29% cov=98%
LMKVILAVDKNFAIGKDGDMLFSIPEDMQRFKELTTGNIVIMGRKTLESLPdsKPLPNRTNIIITSK--DLDGMLCVKNEEELLRTLKEINpdhkmTEYLIGGANTIESLIHLVDEFVITYVDCEFEYDAKIRNlFEDQDFYV--SEESDIKSYEDLDYRYMVFKRK
>UniRef50_B2AX68(4-199:201) Predicted CDS Pa_7_9500 n=3 Tax=Leotiomyceta RepID=B2AX68_PODAN   E=8e-28 s/c=0.63 id=35% cov=99%
-LTLILASTPKMGIGLSGTLPWpSLKKEMAYFARVTKrspspnvQNVVIMGRKTWDSIPakfRPLPDRLNIVVSRSIGgvekREDKSLWAGSLEKALQWVGEDGKgkagrVFVIGGAEIYKAALGLreTRRVLLTRVEREWECDAVFPlELKEgGEWQRVEQQKMDewvgeevprgrQVEKEGTDdetgYEFEMWER-
>UniRef50_Q4U9G5(11-198:523) Bifunctional dihydrofolate reductase/thymidilate synthase, putative n=7 Tax=root RepID=Q4U9G5_THEAN  E=9e-28 s/c=0.66 id=29% cov=98%
-VKILVAITPENGIGIKNGLPWpHIKRDFLFmFRATTYVDPefkekhpgaenvIIIGRNTYDSLPEsvfPLKNRINIVISRNLTEVPGGLVFSSIPSAIRHVTENlnyYKIFIMgifnvvvlkylGGSHVYREVLNakIVDKMYVTRVNKNYECEVFFPKI-PDDF--VITGISKTFSSEDTSYDFVLYERK
>UniRef50_Q256K1(7-155:162) Dihydrofolate reductase n=13 Tax=Chlamydiaceae RepID=Q256K1_CHLFF   E=2e-27 s/c=0.83 id=31% cov=92%
----IVACSPSGVIGNQGKLPWSYSKDIEFFAKTIENKPLVMGRKTWEGLPEKYTKGRQIFVFSRSFYDnaEGVIWVSSLEEFFS-LELPPSVFLIGGGDLFSLFLEnqLLTGCFVTHIHRCYDGDAFFPLSLLVGWNKTI-----LDEQEDL--TFCYYE--
>UniRef50_Q98Q32(17-173:179) Dihydrofolate reductase n=1 Tax=Mycoplasma pulmonis RepID=DYR_MYCPU   E=3e-27 s/c=0.78 id=25% cov=96%
MIISIWAMTKEGLIGKDNQMPWHIKEEFQHFRRQTLHKTLIMGKNTFFSLPKVFDKRKMYVLSHEKDFkidHPDVEVIYDYKDLLKEYanNDKKDIYVAGGLYVYQQLIPLSDILIVSIVKGSYEGNKYL-SVDFSNF-VQYKQPEIYDQ-----FSVYYYKKK
>UniRef50_C0W934(4-200:201) Possible dihydrofolate reductase n=1 Tax=Actinomyces urogenitalis DSM 15434 RepID=C0W934_9ACTO  E=4e-27 s/c=0.62 id=37% cov=86%
-VGAVWAQDAHGVLGADGDMLWRVPADFRHFKATTLGGVVIMGRTTWESIGAALPGRASIVLTREPGWtAPDAVVAGGLDQAVERAEDllaglgpdpreeavraLPRLWVIGGGSVYAQVLAAgcVDELVISVLDLDaaerarqrglaPTQLVHAPQIDPASWHLT-----------------------
>UniRef50_UPI000180BE94(3-163:391) PREDICTED: similar to GA13324-PA n=1 Tax=Ciona intestinalis RepID=UPI000180BE94  E=8e-27 s/c=0.75 id=34% cov=84%
-IHTVSACCKNYGIGFKGSLPWSLPTEFAYFVRLSTGNPppgkrnvVILGRKTWDSKPHARLNRINVVLSRSNKpvqdrNEKPDFVAHSLEEAVAMLESDEwkdkihEVFAIGGHDIYKLVHdsPYCGTVYLTRVDAEYESDTFYPKLD-DSFEL------------------------
>UniRef50_Q3V4E4(15-146:185) Trimethoprim resistant dihydrofolate reductase n=1 Tax=Escherichia coli RepID=Q3V4E4_ECOLX  E=1e-26 s/c=0.91 id=32% cov=72%
----IVAATENGGIGYKGDLPWRLQGDLKRFREITQGGIVIMGAGTYKSLPSPLKDRINIVITKKseisWTACYDVRVVNSPEDALRMVgriidekeeqgRDRPRVFVIGGASIYQALMPFVSTLHWTEVHVE-----------------------------------------
>UniRef50_A5E6H1(10-211:211) Dihydrofolate reductase n=1 Tax=Lodderomyces elongisporus RepID=A5E6H1_LODEL  E=2e-26 s/c=0.59 id=34% cov=98%
---IVAALKPSYGIGNKGKLPWRLRKEMAYFKRVTlrtthTQNAVIMGRKTWESIPvkfRPLPDRLNIVLSRSFANEEqenGVIHANSIGRCVELIKEKNllKVFIIGGSEIYHAFLRekgLVDYLLITEIEQDVknaEGkdkegktkeeevkevemDTFL-KFDTNEWVMGSQEELKEytgeteietnVKEGDFTYNYTIWKRK
>UniRef50_P75478(1-154:506) Segregation and condensation protein A n=1 Tax=Mycoplasma pneumoniae RepID=SCPA_MYCPN  E=2e-25 s/c=0.76 id=23% cov=88%
MITLIWCQDKHFGIGRDNTIPWKLTEANQHFYNTTKNQTVVMGYNTFQELGDKLTDHNVVVLSKKHFEElqnnTNIKVFNSIEKLLQHHFN-RDLYVIGGKQIFHHFIELADRLIISVLPVDFKCNLRL-KLGLDSFELMQEQQH------------------
>UniRef50_Q6FPH0(6-217:217) Strain CBS138 chromosome J complete sequence n=2 Tax=Saccharomycetaceae RepID=Q6FPH0_CANGA  E=6e-25 s/c=0.54 id=28% cov=100%
VVGIVAALLPEMGIGFQGNLPWRLAKEMKYFREVTTltndnskQNVVIMGRKTWESIPqkfRPLPKRINVVVSRSFDgelrkVEDGIYHSNSlrncltaLQSSLANENKIERIYIIGGGEIYRQSMDLADHWLITKIMPLPEttipqMDTFLQKqeleqrfydnsdklvdflpssiqlegrLTSQEWNGELVKGLPVQEK-GYQFYFTLYTKK
>UniRef50_C0R3V1(1-162:162) Dihydrofolate reductase n=8 Tax=Wolbachia RepID=C0R3V1_WOLWR   E=7e-24 s/c=0.69 id=29% cov=87%
MLVIgIMAVDPKGVIGINNGLPWHYPSELDHFRQVTDKQVIVMGRKTFETMPQDiLGNRIPIVFSRDklnscFNRGVKCTIISSMQEFLSIQSNwsYPQIFVIGGAQIAHLFLEYnlISEFIMTEIYKPYKGDVYFNLTLLDGWHKTI----------------------
>UniRef50_Q27713(36-237:587) Thymidylate synthase n=5 Tax=Plasmodium RepID=DRTS_PLABA   E=5e-17 s/c=0.44 id=33% cov=91%
------------GIGNAGVLPWKCNlIDMKYFSSVTSyinennyirlkwkrdkymekhnlknnvelntniisstnnlQNIVVMGKKSWESIPkkfKPLQNRINIILSRTLKKEDivnennnennNVIIIKSVDDLfpILKCTKYYKCFIIGGSSVYKEFLDrnLIKKIYFTRINNSYNCDVLFPEINENLFKITS--ISDVYYSNNTTLDFIIYSK-
>UniRef50_C3WHN9(9-156:164) Dihydrofolate reductase n=12 Tax=Fusobacterium RepID=C3WHN9_9FUSO   E=8e-17 s/c=0.60 id=26% cov=84%
-LKMIVCVGKDNLIGdrtpdeNSNGMLWHIKEELMYFKERTMGNTVLFGGTTAKYVPVELmrKNREVIVLHRTMDVPKLIE---------DLTQENKTIFVAGGYSIYKYFLDnfEIDEIFLSTIKDSVEVkDAveplYLPNIEEYGYKVVEKKEYD-----------------
>UniRef50_Q8MVZ5(1-134:311) Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Tetrahymena sp. RepID=Q8MVZ5_9HYMN  E=8e-16 s/c=0.63 id=29% cov=73%
-----------------------------------------MGRKTWESLPdafKPLSSRINVVVSSKLSAEmlpEGVLLSTSLNDAIKKFENTEevhEIFVIGGERLYKEAIEshIVDRVFLTRMAITMdDCDAFLRGMessvdaNDADSSFVPVAVSPTQVENGVSYDFCVY---
>UniRef50_Q60034(4-139:169) Dihydrofolate reductase n=6 Tax=Thermotogaceae RepID=DYR_THEMA   E=7e-14 s/c=0.58 id=31% cov=70%
-VIFVLAMDVSGKIASSVE-SWSSFEDRKNFRKITTeIGNVVMGRITFEEIGRPLPERLNVVLTRRPKTSNNpslVFFNGSPADVVKFLegKGYERVAVIGGKTVFTEFLreKLVDELFVT----------------------------------------------
>UniRef50_A6LKQ9(23-121:162) Dihydrofolate reductase region n=2 Tax=Thermosipho RepID=A6LKQ9_THEM4  E=1e-13 s/c=0.78 id=36% cov=56%
-------------------------EDKKHFRDLTTkIGTVIMGRKTFESIGKPLKDRLNIVLTNKNFKNDKNILFlkGNPQEIISSLekKNIKSAAVIGGKKVFEEFFPYIDKIFIT----------------------------------------------
>UniRef50_Q8MW00(1-137:259) Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Amastigomonas debruynei RepID=Q8MW00_9EUKA  E=3e-13 s/c=0.55 id=30% cov=74%
----------------------------------------VMGRKTWDSIPqrlRPLKDRVNIVVSRTMlETPEGVHLARSLDDALLVASLVPRvglVSVLGGFQLFAEAMqdPRCTWVELTEVHTAVrEGvgagaavVTNWPgEVDLAAqgfFAEVSR--SERHEESGIEFEYVRYER-
>UniRef50_P04382(1-183:193) Dihydrofolate reductase n=5 Tax=T4-like viruses RepID=DYR_BPT4   E=4e-13 s/c=0.41 id=27% cov=82%
--------------GLGDGLPWgRVKKDLQNFKARTEGTIMIMGAKTFQSLPTLLPGRSHIVVcdlardypvtkdgdlahfyitwEQYITYISGGEIQVSSPNAPFEtmLDQNSKVSVIGGPALLYAALPYADEVVVSRIvkrhrvNSTVQLDASFLD-DISKREMVETHWYKIDE--------------
>UniRef50_Q0BSG2(17-136:153) Dihydrofolate reductase n=13 Tax=Alphaproteobacteria RepID=Q0BSG2_GRABC  E=5e-09 s/c=0.52 id=23% cov=67%
------AIGSGGQLGLNGKLPWQgdqrpaFREDVRRFWERTLGHVLLCGPATYRSIPATAFTARDILELRSSMQPEDV-----------LSRYPGRIVYIGGGlavwNTYARFIQHWD---ITRLPYDGPADRYF----------------------------------
>UniRef50_C6X5G3(5-137:177) Bifunctional deaminase-reductase domain protein n=3 Tax=Bacteroidetes RepID=C6X5G3_FLAB3  E=7e-09 s/c=0.46 id=18% cov=72%
--SLFIATSLDGYIAKPNDDLSFLKlvdkegEDYGYAEFTSTIDTLIVGRKTYDYVLKEIgsshydnGQRDVYVITRTEKPQVGrtIFYTGKIDDLVKQLKSEkgENIYCDGGAEVINELLkhDLIDNLIISVI--------------------------------------------
>UniRef50_A8FAB3(12-138:180) Possible dihydrofolate reductase family protein n=3 Tax=Bacillus RepID=A8FAB3_BACP2  E=2e-08 s/c=0.47 id=25% cov=47%
--------------------------------------TLIMGRNTYEQVlqlspdEFPYEGKTCYIMSRtlQDSLKGTHIIREDILSFVRKLKNEtgQHIWIVGGGELLQSFIKagLVDELYL-----------------------------------------------
>UniRef50_Q1I4U0(10-138:178) Putative uncharacterized protein n=1 Tax=Pseudomonas entomophila L48 RepID=Q1I4U0_PSEE4  E=4e-08 s/c=0.46 id=22% cov=48%
--------------------------------------TLVMGRGTFDKVmtfgQWPYPDVRVVVVSSTlpalpQHSPERVELHPGpIPALLEHLEttGAKSLYLDGG-KLIQGFLRegLVDELTITRI--------------------------------------------
>UniRef50_Q12WB0(6-130:174) Dihydrofolate reductase n=1 Tax=Methanococcoides burtonii DSM 6242 RepID=Q12WB0_METBU  E=6e-08 s/c=0.47 id=24% cov=47%
--------------------------------------VVVMGRKSYEmilsfDVEWPYKFARSYVLTHGNKFEDTDLVKFtniSVKGLVEELssETEKDIWVLGGGEVVREFLDskLIDEIII-----------------------------------------------
>UniRef50_A6FGC8(6-136:181) Putative uncharacterized protein n=1 Tax=Moritella sp. PE36 RepID=A6FGC8_9GAMM  E=7e-08 s/c=0.45 id=24% cov=49%
--------------------------------------AVIMGNTSFQVIKdfddWPYADKQCFVASHSPDitPNDNVTFITDPAATIKQLKASSKgnIWLLGGANLADSLlrLDLVDELILSTI--------------------------------------------
>UniRef50_Q38V13(9-137:179) Putative dihydrofolate reductase n=1 Tax=Lactobacillus sakei subsp. sakei 23K RepID=Q38V13_LACSS  E=7e-08 s/c=0.45 id=26% cov=48%
--------------------------------------TIIMGRKTYEQCIKlagtyPYQEKQSYVFSKTlHDTADRTnVVTGNVPEFVRQLKaqDGGNIWLVGGAETFTMLLKaqLVDELIIT----------------------------------------------
>UniRef50_C0NM00(52-338:368) Putative uncharacterized protein n=4 Tax=Onygenales RepID=C0NM00_AJECG  E=9e-08 s/c=0.20 id=36% cov=81%
------------GIGHAGTLPWpRIKADMTFFSRVTTraaplptpppspddatcaigaVNAVIMGRKTYDSLParfRPLPGRVNVVVTRDasgagsggglkgsggrrrsgsgngpggarrrggerdrdrderggniggtidadaeaeagttDAQPPDVLVADSLESAVSALCDAfrtaptpglltrnstrrlANVFIIGGGEVYASALKLkLDgweaaagkmRIVMTDVRRVstpapspsndatattvgttkaedgeggestavencvngFECDTFFP-LDSDDleeggdggWRRVTTED-------------------
>UniRef50_Q8THH7(8-128:198) Putative uncharacterized protein n=1 Tax=Methanosarcina acetivorans RepID=Q8THH7_METAC  E=2e-07 s/c=0.47 id=22% cov=43%
--------------------------------------TVLIGRKTYEQVLdfgvWPYGEKKTYVFTRQKEplrrEKNVEFVSGNVGEFVRRLKEntDENIWLVGGSQLIRVFLE------------------------------------------------------
>UniRef50_C2ATD9(1-179:189) Dihydrofolate reductase n=1 Tax=Tsukamurella paurometabola DSM 20162 RepID=C2ATD9_TSUPA  E=5e-06 s/c=0.29 id=23% cov=69%
---------------------------------LTKWDTVVMGTTTYRlgtdmGVTDPYSHLRTIVYSRSlaaADFPAVEVVAEDPVEHMRALKQQDggDIWLCGGGKLAATLAPEVDKLAL-KIYPVTAGDgipLFAGGFAPQQWKLVAQRVFDI----------------
>UniRef50_Q5YS10(4-146:193) Putative uncharacterized protein n=1 Tax=Nocardia farcinica RepID=Q5YS10_NOCFA  E=1e-05 s/c=0.36 id=20% cov=59%
-------------------LPTKVRESMGITKRNASFDTVVMGRKTHDfgvrtGTSSPYAHLRQFVVSTTLPEAPDPDLELIADDPLGRVRELKRekglgIWLCGGGELAQVLLPEIDQIFL-----------------------------------------------
>UniRef50_B8L0U0(19-148:190) Riboflavin biosynthesis protein RibD C-terminal domain protein n=1 Tax=Stenotrophomonas sp. SKA14 RepID=B8L0U0_9GAMM  E=1e-05 s/c=0.39 id=28% cov=47%
--------------------------------------AIVMGRATYETVagfdEWPFEGMQVVVLTTRGQiDDPRVRVAGSVEEATRLLEDlgVQDVYIDGGRTI-QAFLraDMVDEITIS----------------------------------------------
>UniRef50_Q02D24(7-131:184) Bifunctional deaminase-reductase domain protein n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q02D24_SOLUE  E=2e-05 s/c=0.40 id=25% cov=43%
--------------------------------------TILWGRKTYDWLlayhkkhglkGEMFDTKVaNFVLSRKPPkrAAPGVEFVAEPVKKFArrlRAEPGKHIWMMGGGELIASFLD------------------------------------------------------
>UniRef50_C2LGH5(14-148:190) Deaminase-reductase domain protein n=3 Tax=Gammaproteobacteria RepID=C2LGH5_PROMI  E=5e-05 s/c=0.36 id=23% cov=47%
--------------------------------------ALVMGRNTLDTIlsfncDWPYT-KPVFVLSNSMTTVPNGyngkvfLVKGELQDIITElnAKGFNELYIDGGVTV-QSFLneDLIDQMIITR---------------------------------------------
>UniRef50_C0EE44(35-160:208) Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum DSM 5476 RepID=C0EE44_9CLOT  E=0.0002 s/c=0.37 id=18% cov=42%
--------------------------------------TILMGMKTYLQIvtelspnNWPYRKKKSVVFTHRkmHSTEFVEFVSGDAADFVSQLRkqQGKDIWVCGGAELVSQLI-------------------------------------------------------
>UniRef50_A7HVX5(3-167:169) Dihydrofolate reductase n=13 Tax=Proteobacteria RepID=A7HVX5_PARL1   E=1e-47 s/c=1.15 id=42% cov=99%
-VSYVVAIADNGVIGRDNSLPWRLSGDMAFFKRITMGKPVIMGRKTWESLPRkPLPGRPNIVVTRDAQYEaEGAEIAASAVEALRRgrelasASGADEVMVIGGAQLYAEMFDDATRLYITEVHAAPEGDVSFPAFDAAHWREVSRERHKAGEKDSADYSFVVLER-
>UniRef50_Q11US6(1-161:161) Dihydrofolate reductase n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11US6_CYTH3  E=5e-46 s/c=1.15 id=39% cov=99%
MIrSIIVAQSENRAIGINNTLPWHLPADLKRFKAITMGHHMIMGRKTYESIGNPLPGRTSIVVTRNKDLVfAGCTMAHSLAEAFEIAQNNNdsEAFVIGGAELIKEAINSCDKLYLTTIHQNFEGDTFLDAL-ASDWKETEHVVHAPDDKNAYSYSFITYEK-
>UniRef50_C1SJK6(4-153:156) Dihydrofolate reductase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SJK6_9BACT  E=1e-42 s/c=1.16 id=35% cov=94%
--ALIVAMTKDRVIGKNNDMPWHLPEDLKLFKAKTTGHIIAMGRKTYESIGRPLPNRENFVITRSGKEYDGCRVFGSVQECIKAAEEYDKtLFFIGGGQIYSDAVDMVDEMHISYIKENYDGDTFFPEFDESRWKVTETEEYG-------DFIYKKFVR-
>UniRef50_UPI00016B2267(17-176:178) dihydrofolate reductase n=1 Tax=candidate division TM7 single-cell isolate TM7c RepID=UPI00016B2267  E=3e-40 s/c=1.03 id=42% cov=97%
--AIIVAYDRNRAIGRGGDLPWgrSLPADLAHFKQLTKGGGIIMGHRTFESIGsRPLLERKNIVISSRPTDSEGVLTVMDLPSALALSHYST--FIIGGARVYADALetPEIDTIYATEIDASFPGaDTFFPEIDMSIWQETSRIRHPADADNVYDFDFVIYKR-
>UniRef50_A6WGF8(1-157:171) Dihydrofolate reductase n=5 Tax=Actinomycetales RepID=A6WGF8_KINRD   E=4e-40 s/c=1.05 id=40% cov=97%
MIGLVWAQSRNGVIGAGGRIPWRVPEDLAHFSALTAGSTVVMGRATWESLParfRPLPGRRNLVLSRDPGYaAEGAEVVHDLPGALAGAGD---VWVIGGSAVYRAALEHADVLVVTEVDLVVEGDTRAPEVGPG-WERVEVGDW-ATSTGGPRFRIGTWRR-
>UniRef50_B9XJM4(5-130:156) Dihydrofolate reductase n=1 Tax=bacterium Ellin514 RepID=B9XJM4_9BACT  E=2e-39 s/c=1.29 id=46% cov=79%
----IAAMSQNRVIGQGNKIPWHLPEDFKWFKKMTTGQVVVMGRKTFESIGRPLPNRETIVLSRGPFQHPGVRTIFDLSE-ISLADESREIFICGGAQIYEQTLPMCSDLYLTVLKRTVEGDAFFPTFE------------------------------
>UniRef50_D0VXF2(3-161:168) Putative uncharacterized protein dfrP n=1 Tax=Bacillus phage phiNIT1 RepID=D0VXF2_9VIRU  E=7e-39 s/c=1.01 id=36% cov=99%
-VALIAAMGLNLEIGADNRLLWDIKEDMNWFRQKTKNKVVVMGRKTYESIGKPLKGRVNVVLTHNKEYDphPDVLVRHNLEDIFFEFRNELEIMVIGGETIYNQFFPYANRIYLTQVEKTYeEADAFFPEFDCSIWNRYFYQDGSEDI--GIKYNFSVYKKR
>UniRef50_C3RMT4(1-155:156) Dihydrofolate reductase n=4 Tax=Bacteria RepID=C3RMT4_9MOLU   E=7e-39 s/c=1.04 id=38% cov=96%
MINIIVATDEDLLIGKKdsrNGMPWNVPEDLQHFKATTLNKTILMGLTTYQAIGRPLPNRKTIVVSFEPFEDERVEVRSSLEEVIEEYRSSgEDLFISGGASIYKQCLPIADQLLISRIPGKHEGETYFPNFDEYGYKLVAQKPFE-------TFTLETYKR-
>UniRef50_C3XD45(4-159:163) Dihydrofolate reductase n=2 Tax=Oxalobacter formigenes RepID=C3XD45_OXAFO  E=9e-39 s/c=1.03 id=36% cov=97%
-ISHVVAMAENRVIGKDGQMPWHIPGEQKIFRELTVGKALILGRKTHESIGRVLPDRITIIVSRKKDYEvPGAHVVHDIDEAIRLAREfgKEDIVIGGGGELFSQTLPVTDKVYLSIVHADFDGETFYPELPKEEFVEKARKEIDA----SIPYAFVEFER-
>UniRef50_UPI0001874368(15-173:176) dihydrofolate reductase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI0001874368  E=2e-38 s/c=1.01 id=37% cov=99%
-VGMIWAQSRAGIIGDGATMPWHLPEDLQHFKTTTMGAPVIMGRRTWDSLNpkfRPLPGRRNIVLSRSVSDFPGAESATSLEAALAAVADEPAAWIIGGGRVYRDALSLADECVVTDIDTDVSVPVPVMAPDLYDWVRVEDGPWQTST-TGLRYRFCTWQR-
>UniRef50_Q7UIC9(31-187:195) Dihydrofolate reductase n=1 Tax=Rhodopirellula baltica RepID=Q7UIC9_RHOBA  E=2e-38 s/c=1.02 id=37% cov=99%
-ITAVVAATPNGVIGDDQDMPWRLSSDLKRFKKATMGGALIMGRKTFESIGRVLPGRQTIVLTRQGHWQfPGTQTASGKSEAIALAAD-RRIFVVGGGQIYQQWFPLCTELWWTRVWANVSGDTRV-DLPLDEFELVSQTSFPVTAKDDYPTDWLRMRRR
>UniRef50_Q0TV23(1-160:161) Dihydrofolate reductase n=8 Tax=Clostridium perfringens RepID=Q0TV23_CLOP1  E=2e-38 s/c=1.00 id=34% cov=99%
MFSIIVAKSINNIIGVNNKMPWNIPSDLKRFKELTMGKKILMGRKTFESLPFVLPGRTHLVLTTKKDFsynHKDVIIYNDLNKLISEYKDSmEEIFVIGGGKIYSELLKYTSKLYITEVLKEYKGDTYFPKVDYYKWIKTYE--SSIHEENGNKFKFFNYKK-
>UniRef50_D0J8Z9(3-172:173) Dihydrofolate reductase n=2 Tax=Blattabacterium RepID=D0J8Z9_BLASP   E=2e-38 s/c=0.94 id=36% cov=99%
-IILISAVSSNGVIGKNNQLMWHLPNDLKRFKNMTFGETVLMGRKTFESIGKILPGRRNIILTKKNKIHffsstntnnktnprGTFEVYSSLKQIYDL--NYKKIFVIGGEKIYTSTIDKAHIIELTVIHKKFYGDAKFPKIPLSKWKKTYEFFHEKDKHHLYNYSFIRYERK
>UniRef50_A7SCT0(9-185:187) Predicted protein n=2 Tax=Nematostella vectensis RepID=A7SCT0_NEMVE   E=3e-38 s/c=0.90 id=31% cov=99%
--SCIVAMDLKRGIGKNNDLPWKIKGDMKFFTEKTsevktegKQNAVIMGRKVWESIPekfRPLKGRLNIVLSRTLSEPPqGAQLCRSFEQALTILstdpytKKIENVFVCGGSALYKDAMAHsaCTRIYITYIDQEFDCDVFFPEFDQNTYHLVEDPDVPsvQHEEKGIKYKFCVYDR-
>UniRef50_C3Z0P2(6-183:185) Putative uncharacterized protein n=2 Tax=Deuterostomia RepID=C3Z0P2_BRAFL  E=3e-38 s/c=0.89 id=34% cov=99%
-LSLVVAACNNMGIGVDGKIPWTLRGDMKFFSRLTSGteeagkqNAVVMGRKTWFSIPdrfRPLPKRLNVVLSRNLTTPPEgaHHLAGSLEEAVKMltettvADTIDKVFIIGGNSVYKDALshPCCHRVYLTRVYKDVHCDTFFPNMD-DTFKLVSdpTIPSEMQEENGIEYKYEVYEK-
>UniRef50_B2GC42(4-160:167) Dihydrofolate reductase n=4 Tax=Lactobacillus RepID=B2GC42_LACF3   E=9e-38 s/c=1.00 id=34% cov=97%
-IAFIWAEDEAGWIGKDNDMPWHLSADLKHFKHLTSGHPVIMGKNTYLSLGRPLPKRTNIVVTRQTTPIEGVTLvngVNALTDLLANYGEDEEVFIIGGAHLFASTMSLATVLYRTVVEGDHHGDVKMAPIDYRTWQKVA-ERHLQATESDPACTFEKW---
>UniRef50_UPI0001C35E5E(1-162:167) dihydrofolate reductase region n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C35E5E  E=1e-37 s/c=0.97 id=31% cov=99%
-MKAIVAVDEAWGIGKDGKLLTHLPEDMKFFRTVTKGKVVVMGRKTLQSFPdaKPLKNRINIVLTSDAALNgEGLIVCRSVADALRQLKeyDSDDVYIIGGQSVYEQFLPYCDTAYVTRMKRDFGADTWFVNLDRQEgWEET--ETGDEKEYEGLHFTFCTYKNR
>UniRef50_Q6A328(6-169:169) Dihydrofolate reductase n=1 Tax=Pasteurella multocida RepID=Q6A328_PASMU  E=5e-37 s/c=0.95 id=31% cov=99%
--SLIVAIGKHREMGADNDLLWHLPRDMQFFKETTTGHAVVMGRKSWESIPqkyRPLPNRLNFVLTRDKNYsAEGATVIYDLKEVAQHLEGKNlTCFIIGGAQIYQLALEtgLLNEMYVTQVHNTFeEADTFFPFVNWGEWEEEDILEQDKDEKHLYSFNIKKFTR-
>UniRef50_A5WHY1(11-188:193) Dihydrofolate reductase n=4 Tax=Moraxellaceae RepID=A5WHY1_PSYWF   E=7e-37 s/c=0.87 id=37% cov=96%
----IVAISRNRCIGKGNDLPWHIPNDLKHFKAMTTaetdayvdtglKGIVIMGRKTFESMGsKPLPKRVNFIVTTQMDYAqqkgleglKDVHVVHNLDDALTHAANVahglkfETIWVIGGERVFKRAMMFTDRIELTVVDTDIEdGDAFYPEI-PEDFELTQESESFTDEKSGLSYKFMTY---
>UniRef50_B7C7C2(3-159:159) Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM 3989 RepID=B7C7C2_9FIRM  E=5e-36 s/c=0.96 id=31% cov=96%
-LTLIAAIGKNRELGKNNDMIWHLPQDLKFFRQETSGHTIVMGRKTFESLPGKLPKRHHVVISRTCkDLGEDIEMCESVEEFMKRYKDvDEEIYCIGGGMIYSEMLKYASRLVLTQIDADADAEVYFPEFDESLYNK---KILSNIEENGVFYQHVEY---
>UniRef50_C1C2C0(9-174:178) Dihydrofolate reductase n=1 Tax=Caligus clemensi RepID=C1C2C0_9MAXI   E=9e-36 s/c=0.91 id=34% cov=97%
-INVIAAACKsSRGIGKDNDLPWKLPTDMKYFREKTASTTeirvgVIMGRRTWESVPpkfRPFKNRFNVVLTSREDFEAkGAVIARTLEDAVKKCsNNVDSIWVIGGSGVYAEALNkYPCRVYLTEIDKEFDCDAFFPPLDEKKYKLAS--VSPDHQENDITFRFKVYD--
>UniRef50_C7REN4(1-159:164) Dihydrofolate reductase region n=2 Tax=Anaerococcus RepID=C7REN4_ANAPD  E=1e-35 s/c=0.94 id=29% cov=99%
-MKIILAVDKNWGIGKDGQMLFHIRRDLKHFKSYTLGNICIMGRKTYESMGGALTHRENIVLSRNKDYKAkDAKVFTDYRDVLSYVRErSEEVFVIGGEKIVEIFLEYCDEAIITKIYEKKDADSFLHNFDQdDDWSL--SEESDIMEENGVSFRYVRYRRK
>UniRef50_Q8JKV3(87-258:264) Dihydrofolate reductase n=1 Tax=Heliothis zea virus 1 RepID=Q8JKV3_9VIRU  E=1e-33 s/c=0.83 id=38% cov=99%
-INLIVAVCENNmGIGMNNALPWHLKREMAHFTKTTTTathpnkNAVIMGRLTWESIPkrfRPLPGRVNIVLTTKHrGDYDGATRVSNFDEAIRVVEsrgDIETAWVIGGASVYAAAMthPNCHQIHLTAIKKYYECNVFFPKIDTTRFELISET--PCTREGDVQYSYKVYQQR
>UniRef50_P78218(3-156:157) Dihydrofolate reductase type 15 n=153 Tax=root RepID=DYR15_ECOLX   E=4e-33 s/c=0.92 id=33% cov=96%
-LSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGA-LPNRKYAVVTRSsfTSSDENVLVFPSIDEALNHLKTiTDHVIVSGGGEIYKSLIDKVDTLHISTIDIEPEGDVYFPEI-PSSFRPVFSQDFVSN----INYSYQIWQK-
>UniRef50_P27422(3-156:157) Dihydrofolate reductase type 7 n=46 Tax=Bacteria RepID=DYR7_ECOLX   E=4e-32 s/c=0.90 id=32% cov=96%
-ISLISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMG-VLPNRKYAVVSRKgiSSSNENVLVFPSIEIALQELsKITDHLYVSGGGQIYNSLIEKADIIHLSTVHVEVEGDINFPKI-PENFNLVFEQFFLSN----INYTYQIWKK-
>UniRef50_A8SNM7(6-165:166) Putative uncharacterized protein n=1 Tax=Parvimonas micra ATCC 33270 RepID=A8SNM7_9FIRM  E=2e-31 s/c=0.85 id=32% cov=97%
-LYLIVAITEKtNAIGKDNNLLYFLKEDMNFFKEKTCDNSIICGRKTFEGFKiKPLPKRKNIVLTKSDFSFEGVRRFKNIEDLINFVKENpkEKFFVCGGMSIYEQLIDFCSRMYITKYEEKeaVEADSHFPKIDEKVWKVV--EKIDGKSENP-KLTFYTYER-
>UniRef50_P47470(1-156:160) Dihydrofolate reductase n=2 Tax=Mycoplasma RepID=DYR_MYCGE   E=4e-29 s/c=0.82 id=24% cov=94%
MLIAIWAMTQEGLIGNNNTLPWMIKQELAHFKKTTLFQALLMGRKTYESLPKVFEKRTIFLLSKDQNYRfeekgSEVKVINDFWPLIKsyQANKEKDLFICGGKSVYEQTINECDQLIVSIIKKKYKGDQFL-KVDLSKFVLNEVVEFEEFNVNYYR---------
>UniRef50_D0NVQ6(8-152:174) Putative uncharacterized protein n=1 Tax=Phytophthora infestans T30-4 RepID=D0NVQ6_PHYIN  E=4e-29 s/c=0.88 id=35% cov=81%
-VSLIAACSVNRVIGKQGRLPWNLPADWAFFSTATQNQVLVVGRRSFEEFDEPIPNRHTIVVSSTLQKLqvdatnarwPSVQFARTLEQALQLANTDPqyrncnRVFVGGGERLYKEAMDseVADSCYVSRVHQYItDGDTFFPEW-------------------------------
>UniRef50_C3JYD2(7-160:165) Putative dihydrofolate reductase n=1 Tax=Pseudomonas fluorescens SBW25 RepID=C3JYD2_PSEFS  E=5e-29 s/c=0.83 id=33% cov=93%
---------RNRSIGKAGGLLRMVPDDMRRFAAKTIGKPVIMGRKTFESVialsGRPLADRPNIVLSRNPAFEhEQAVVCRSLASALECAAsyHPEEIHIGGGPELYDQVIDRVDRLYLTLFNDDHEGEARFPSF-EDEFIEV--CHHGVREHEGLAYEWVDYVRR
>UniRef50_A9NG26(1-154:156) Dihydrofolate reductase n=1 Tax=Acholeplasma laidlawii PG-8A RepID=A9NG26_ACHLI  E=3e-27 s/c=0.79 id=29% cov=94%
MIYAIWAMDVNWLIGQDNKLAWHYKEDLAYFKEKTKGKTVLMGDLTYKSLKgyykdKPFPYGKIYVANLIDTAYDDAECITDVVDFVKNYKD--ELWIIGGKVIYNLTLPYVDYLLITHVLDIHKGNVYFNHFDLSSYKLV-------DKKLAPSLIFATYKK-
>UniRef50_Q5V3R2(9-175:185) Dihydrofolate reductase 1 n=1 Tax=Haloarcula marismortui RepID=DYR1_HALMA  E=5e-27 s/c=0.73 id=33% cov=88%
-LVLVVAADENNVIGLDGGVPWHYPEDVRQYKNRIAGHPIILGRRTFESM-KPIPDCYTVVLTSDDRRSADSETVEYAttpqiaveaaaragasgafaGDSAGADSSPPVTYVIGGEAVYDLFLPFAGRVFLSRIHEHNEGDRYFPDLG-AEWTELSREPHD-----------------
>UniRef50_C4G1L6(3-142:165) Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC 49176 RepID=C4G1L6_ABIDE  E=1e-26 s/c=0.86 id=38% cov=79%
-IKLIAAVDLRFGIGKDGSLLFKIPEDLRLFKQLTTGNIVLMGRKTFESIGcIPLTDRINIVISSAKKYEnEDVINFDNYKTAIEYCKQifsDKDLYIIGGGKIYEQGIKYADEIILTKYNKVYEdVDTYFP---------------------------------
>UniRef50_C6YJR8(8-184:184) Dehydrofolate reductase n=6 Tax=Vibrio RepID=C6YJR8_VIBCH   E=5e-25 s/c=0.65 id=31% cov=96%
--SMIVARGVNGEIGQDGDLPWHvegvrLKEDLKRFKAITMGKTLVMGRKTFESIPNGLPGRNVIVLTREPYDKaditergDGTFVAwgnsCHLFEVAEHL-GVTEIIVAGGAEIYNLHKDVITKVFETKVLRAYPAadthvDVFWesPGYDTEgrQWRVTSRGH---IIENGSFTIATTYER-
>UniRef50_B8BYC4(21-204:214) Putative uncharacterized protein n=1 Tax=Thalassiosira pseudonana RepID=B8BYC4_THAPS  E=5e-22 s/c=0.57 id=30% cov=94%
---IVAALTKNGVIGINGSLPWeSLTQDRDHFINLTRGKVLILGRKTFvdedPSGGHVDHARACIVVSSTMYYSRShgstlVKVARSLDEALVMANKLNtssgitktrnssiDCWVAGGERLYKDALqhPCAAEVHLTQVDITISTDmlatkdevAYFPVdyLNNYGFQEVSKREDGI-------CVFCVYKRQ
>UniRef50_Q27783(30-197:527) Thymidylate synthase n=25 Tax=Trypanosomatidae RepID=DRTS_TRYBB   E=4e-21 s/c=0.61 id=35% cov=65%
--SVVVASDEKGGIGDGGTIPWEIPEDMQYFRRVTTNlrgknvkpspskrNAVVMGRKTWDSLPpkfRPLSNRLNVVLSRSATKEqllagipdpikraeaanDVVAVNGGLEDALRMLvskehtSSIETVFCIGGGTIYKQAL-------------------------------------------------------
>UniRef50_D2E8H0(1-224:227) ORF119 n=1 Tax=Anguillid herpesvirus 1 RepID=D2E8H0_9VIRU   E=2e-20 s/c=0.45 id=26% cov=95%
---LIVARNLNGAIGRGGRLLYKLPKDLQRFRDLTQDQIIVMGRKTFETLPRVLPRRRHVVLSKsapainihdpclqelatnregvwiRNWTVEQVRSLESLPRLLSPADKTRttcqinqikpkdclysflpaqarvsgaeidktarsKLFIIGGAEVYNLFWKHCSVLHITKVVASE------PKPRHEEEDLVSWAVSDSQlrtlfdltlsvpcHDNGFGIIFETWRKK
>UniRef50_Q8MVZ9(1-126:314) Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Cercomonas longicauda RepID=Q8MVZ9_9EUKA  E=1e-18 s/c=0.75 id=30% cov=74%
----------------------------------------VMGRKTWDSLKKPLIQRVNIVLSRQGFSHptDNVVVCSSLERAFEHARmrhPTKRVFVIGGEEIYRQTIAHAQRIYLTRVFlpesRTPHFDSYFPYRDlQSHFSRILSSDLEFQPESGIGWRFEEW---
>UniRef50_B7XJG7(14-138:197) Putative uncharacterized protein n=1 Tax=Enterocytozoon bieneusi H348 RepID=B7XJG7_ENTBH  E=4e-11 s/c=0.56 id=32% cov=75%
-LNIMVAFTrEKKIIGQGMKLPWgRLNADrlfMLWAIKTGNNGTIIMGRKTSEVARFPKIKK--IIVSQ---TKEGDCYVKKFEDGIQKC--TSPIIVMGGEGIYKEALQHQCRIFCTIIEDEdwIKGDVFFP---------------------------------
>UniRef50_Q3M517(4-135:172) Bifunctional deaminase-reductase-like n=1 Tax=Anabaena variabilis ATCC 29413 RepID=Q3M517_ANAVT  E=5e-10 s/c=0.50 id=20% cov=72%
-IILFIASSLDGYIARDsGDIDWLFTDqDYGYTEFIAQIDTLIMGNKTYQQIltfgEYPYQDQEVFVFSKTYSGETNNgakYINSDWEDFIKTLRtsNGRDIWLVGGAQLIHFFLKHgfIDELILS-IH-------------------------------------------
>UniRef50_A8VQB2(7-135:180) Amine oxidase n=2 Tax=Firmicutes RepID=A8VQB2_9BACI   E=1e-09 s/c=0.50 id=23% cov=30%
-VTLFIAMSLDGCIAtSDHSLDWLEQvegeGDNGYEKFYSTVDTVLLGRKTYD---------------------------------------------------------------------------------------------------------------
>UniRef50_A8TN13(8-121:172) Dihydrofolate reductase n=1 Tax=alpha proteobacterium BAL199 RepID=A8TN13_9PROT  E=1e-09 s/c=0.56 id=27% cov=42%
---------------------------------MTEVDVLVMGRATYDQVlgfgKWPYPGKRAFVLTSRPigDAPDGVEGTSDIAGLIAELRDEGaQVWIVGGAE-------------------------------------------------------------
>UniRef50_B8EQ73(4-123:131) Dihydrofolate reductase n=1 Tax=Methylocella silvestris BL2 RepID=B8EQ73_METSB  E=5e-09 s/c=0.52 id=29% cov=30%
----ICAIGRRGQLGLDGRLPWegnpgrEYKADVARFFDLTRGHVLIAGPRTIASFP------------------------------------------------------------------------------------------------------------
>UniRef50_Q2SB85(3-134:175) Dihydrofolate reductase n=1 Tax=Hahella chejuensis KCTC 2396 RepID=Q2SB85_HAHCH  E=4e-08 s/c=0.45 id=19% cov=49%
--------------------------------------ALVMGSKTYLKVlelgAWPYEGKPVWVFSRQEDlkLAPGVERCAGDPSTIVAhfrALDYKRVWLVGGGELLASFQeeDLVDEYIISYV--------------------------------------------
>UniRef50_C6Z7D7(3-122:165) Putative uncharacterized protein n=1 Tax=Bacteroides sp. 4_3_47FAA RepID=C6Z7D7_9BACE  E=8e-08 s/c=0.49 id=23% cov=69%
-VTLIASVSANGKVLLANN-PNHqiAPEVMGFLvqKAIESGN-IVFGYSTYtmfiDALQDALAGKEIVVLSNNHEARSGHKTVHTPEEAVEYLKGKgmEEIVVGGGVQTYNAFLdkDLVTDIY------------------------------------------------
>UniRef50_Q03E11(5-139:177) Dihydrofolate reductase n=23 Tax=Lactobacillales RepID=Q03E11_PEDPA   E=2e-07 s/c=0.42 id=27% cov=39%
--------------------------------------TVIMGRTTYEQVtqklspeKYVYADRQTYIVTSHLGEDTDKIkyWKQSPVELVKRIQKEkgKDVWIVGGAKL------------------------------------------------------------
>UniRef50_D2RU55(6-139:184) Bifunctional deaminase-reductase domain protein n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RU55_9EURY  E=2e-07 s/c=0.43 id=22% cov=48%
---------------------------------------LVMGSRTYEQLlsfdGWPYGERPTFVVTSRDlplATAHVELVAGNLRELVDGLEErYDRIWLVGGAALAQSFLRegLVDEIRLTVV--------------------------------------------
>UniRef50_Q8NSF5(1-145:189) Dihydrofolate reductase n=3 Tax=Corynebacterium glutamicum RepID=Q8NSF5_CORGL  E=2e-07 s/c=0.39 id=20% cov=70%
MMAIIYNTSstLNGFIAdKDNSLQWLFdvpgsdgaSEDFGNF--LSKAGTIVMGSTTYEWLLKdldfisdphkwtdVYGDRPTWVFSSRNLETPegkpvkvvNGDVADVLPAILEESPENTDIWIVGGGDLAGQFFDagALDRIILT----------------------------------------------
>UniRef50_B8FSZ4(8-116:181) Bifunctional deaminase-reductase domain protein n=2 Tax=Desulfitobacterium hafniense RepID=B8FSZ4_DESHD  E=2e-07 s/c=0.52 id=25% cov=42%
--------------------------------------TLLMGRRTYEIVratGESFRGKQVIVASRSlrpVDHPDVEIVSEGLEARVRELRGQPgrDIWLYGGGNLFSQLL-------------------------------------------------------
>UniRef50_A0JWM1(4-140:180) Bifunctional deaminase-reductase domain protein n=2 Tax=Arthrobacter RepID=A0JWM1_ARTS2  E=3e-07 s/c=0.41 id=19% cov=48%
---------------------------------------IVMGGDTYAWLmehepdNWPYPDTPCWVFTHHEHSAPRgadvTFVRGDVQEFMddfRADAGGKNVWLVGGGELAAQFADagLLDEIIVSII--------------------------------------------
>UniRef50_C6CWT2(42-122:169) Dihydrofolate reductase-like protein n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CWT2_PAESJ  E=2e-06 s/c=0.66 id=28% cov=41%
----------------------------------------IVGRRTFEGMrgnggPGPFGEVDIVIISKSASDIPGVTVVRSPEEALNHLrqKGHQTALISGGAEIHNSFL-------------------------------------------------------
>UniRef50_A0QP85(8-134:175) Dihydrofolate reductase n=3 Tax=Mycobacterium RepID=A0QP85_MYCS2   E=2e-06 s/c=0.42 id=22% cov=48%
--------------------------------------VLVMGASTYEWVvehgdwsydqpAWVLTHRPEIAAESHPMQVFSGDVAE-LHPELVAAAGGKDVWVVGGGDVAAQFVaaDLIDEIIVSY---------------------------------------------
>UniRef50_A1R2K6(4-182:201) Riboflavin biosynthesis protein RibD n=6 Tax=Bacteria RepID=A1R2K6_ARTAT  E=3e-06 s/c=0.30 id=23% cov=67%
----------------------------------TMFDTVVMGWNTYAvglpvGMTSPYQHLKQVVFSRTrtesdvPGEHPNLKVTDeDPVEVVRRLKSEPGqsIWLCGGGQLATQLAGEIDRLVLKRSPVLF-GDgipLFAPgTYQPSAFNEVSTTAF------------------
>UniRef50_C7NL56(16-143:196) Dihydrofolate reductase n=2 Tax=Micrococcineae RepID=C7NL56_KYTSD   E=2e-05 s/c=0.39 id=36% cov=36%
---------------------------------------LVMGRGTYEKVltfdGWPYGGKKVIVMSTTLESDDDrITIARSLDNAQRtlAASGARQVYVDGG---------------------------------------------------------------
>UniRef50_C2AUH3(9-163:181) Dihydrofolate reductase n=1 Tax=Tsukamurella paurometabola DSM 20162 RepID=C2AUH3_TSUPA  E=3e-05 s/c=0.32 id=21% cov=45%
---------------------------------MTAVGAIVMGYTTYQWVvdhetgsgaEWPYAQYPTFVFTHRDIEPvhETVTVVSGEPAAqrsrLERVAGEKGVWVVGGGDLAAQF--------------------------------------------------------
>UniRef50_C2HCB0(1-131:173) Dihydrofolate reductase family protein n=12 Tax=Enterococcus RepID=C2HCB0_ENTFC  E=7e-05 s/c=0.37 id=27% cov=39%
----------------------------------------IMGRKTYQEAKKyleteaIYPEKKNFVFSTNAQLQlPDAEVVHEEPVAFLKnlqMTEGKDIWVVGGGRLIK----------------------------------------------------------
>UniRef50_C9SEJ7(9-121:181) Bifunctional deaminase-reductase domain-containing protein n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEJ7_VERA1  E=0.0003 s/c=0.41 id=28% cov=41%
----------------------------------------VMGRKTYEAMLHhgetsganPLADHHVIVISktlKQKDHPDIEIVRDDYLDVVRNLKsgQGKDIWLMGGGRLASEFL-------------------------------------------------------
>UniRef50_Q1CZU3(3-159:159) Dihydrofolate reductase n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1CZU3_MYXXD  E=8e-48 s/c=1.22 id=43% cov=97%
-LSAIVAMAANRVIGAGNQLPWRLPADLARFKRITMGHTLVMGRKTYESIGRPLPGRTFIVVTRQRDFaPPGVQVAHSVDEALSLAKasGDSEVFIAGGADLYAQTMDRVQRIYLTHIARNFPGDTWFPDVDLSGWTCVEEQAHPDAE---PPHTFLTYER-
>UniRef50_D0J2N2(3-166:167) Dihydrofolate reductase region n=3 Tax=Bacteria RepID=D0J2N2_COMTE   E=5e-47 s/c=1.15 id=42% cov=98%
-IQLIYARAANGVIGKDNTMPWHLPEDMAHFKELTRGCAVIMGRKTWDSLPprfRPLPGRSNIVVTRQADWQaepasDQVLRAASLSEALELGRNlSQDVWVIGGAQIYAQALPLADAVEVTEIGRDFEGDAFAPELG-EQWQAVSRSEH--VSANGLPYCFVRFERR
>UniRef50_A1WMP6(3-160:162) Dihydrofolate reductase n=2 Tax=Proteobacteria RepID=A1WMP6_VEREI   E=4e-45 s/c=1.15 id=36% cov=97%
-LHLIYARAANGVIGKDGRLPWHLPQDMAHFRQLTQGCSVIMGRKTWDSLParfRPLPGRSNIVVTRQSDWHaDGARRAASLEQALALCDARQTAWVIGGAQLYAQALPLADCVEVTEINQDFDGDAHAPTLG-AEWVEIRRSRQP--DQHGLAFSFVRYAR-
>UniRef50_Q5V600(5-161:167) Dihydrofolate reductase 2 n=1 Tax=Haloarcula marismortui RepID=DYR2_HALMA  E=1e-39 s/c=1.04 id=45% cov=95%
-LSLIAAVAANGVIGAGGDIPWQYPEDLTHFKETTVGHPVIMGRRTFESIRRdldgPLPERLNIVLTTTPHQlPDSVTAVTSTTAAVAEAADSDasTTYVIGGATVYEQFLPQADELILTELAAAFDGDTVFPTVDWSNWTEMERTTHSE-------FAIVRYTR-
>UniRef50_Q59408(8-163:165) Dihydrofolate reductase type A13 n=57 Tax=Bacteria RepID=DYR13_ECOLX  E=6e-39 s/c=1.03 id=35% cov=97%
-IYLVAAMGANRVIGNGPDIPWKIPGEQKIFRRLTESKVVVMGRKTFESIGKPLPNRHTVVLSRQAGYsAPGCAVVSTLSHVsPSTAEHGKELYVARGAEVYALALPHANGVFLSEVHQTFEGDAFFPVLNAAEFEVVSSE----TIQGTITYTHSVYARR
>UniRef50_Q1GFV5(1-137:163) Dihydrofolate reductase n=18 Tax=Rhodobacterales RepID=Q1GFV5_SILST   E=1e-37 s/c=1.15 id=42% cov=84%
MITLIVARARNGAIGKDNDIPWHAPEDLKAFQRETLGGAIIMGRNTWDSLPfKPLKNRFNIVVSSNPDAAD--TVVASLDEAIDLArsEGYARLYGIGGAGIYKGMLARADRLMITEVDLEIdDADAFFPEFPPEEWR-------------------------
>UniRef50_D1BYH5(1-185:185) Dihydrofolate reductase n=1 Tax=Xylanimonas cellulosilytica DSM 15894 RepID=D1BYH5_XYLCX  E=4e-37 s/c=0.84 id=38% cov=101%
MIALIWAQARDTagrpVIGAGGDIPWRVAEDFTRFRTLTTGHPVVMGRRTWDSLPrRPLPGRTNVVVTRQPDWRPDddgavvtagapeataVVVATTLDEALDGATQAPGgdlVWIIGGAEIYGQALAVADRLEVTEIDLVVDGDAFAPAIDPVHWHEGQHGHGDWVSparPESPRYRFRTYVRR
>UniRef50_A1WYQ0(4-160:164) Dihydrofolate reductase n=1 Tax=Halorhodospira halophila SL1 RepID=A1WYQ0_HALHL  E=2e-36 s/c=0.97 id=39% cov=97%
-IVLVAIVGRNGVIGADGDQPWHFRCDLQRFKALTRGHPVIMGRRTLAAIGRPLPQRTNIVLTRDPGFHaDGVEVATDPEaalARAAESAGGERVMILGGGDVYRLFLPRAHRLALTEVDDAPPGDTTFPAIGP-EWQETAREE---AEEDGYRLTFRTLLR-
>UniRef50_C9KQJ5(168-322:342) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase n=2 Tax=Veillonellaceae RepID=C9KQJ5_9FIRM  E=8e-36 s/c=0.97 id=34% cov=93%
-LSMIACIDEGRGIGYRGELLVHLPEDMKHFRALTEGHVVIMGRRTMESLPgkRPLVNRQNIVLSRQLEGAEGFLICHSLPDLWRALgrlraeKPQRKLWCIGGEELYRALLPYAHEVCLTRLKAVYPADCFFPPLD--DFSLV-----DTDDREGL--VFERYE--
>UniRef50_A9HP20(1-137:154) Dihydrofolate reductase n=1 Tax=Roseobacter litoralis Och 149 RepID=A9HP20_9RHOB  E=6e-34 s/c=1.05 id=37% cov=82%
------ARAENGAIGRDGTIPWNVPEDLKFFQRETLGGALIMGRNTWESLPvKPLPRRFNVVVSSNSDTAEVVAPSVKVAIELAIEHGHQRIYGIGGAAIYQEMLPLAHRLLISEVQIDVpDADTFFPNFDVAGWKAI-----------------------
>UniRef50_UPI0001926A4C(10-183:189) PREDICTED: similar to Dihydrofolate reductase CG14887-PB n=1 Tax=Hydra magnipapillata RepID=UPI0001926A4C  E=1e-33 s/c=0.83 id=36% cov=96%
----IAAIDSEWGIGLKGKLPWNLPREYKFFQNITTkvisegkQNAVIMGKNTWFSIPqqhRPLKNRLNVILSSSFikeDYPKNVLLESSLEAAILRLSDEfyantvENIFVIGGSRVYKEAMEkFCDKIYLTKIEQDYSCDVFYPIFDTNKFKEIDDEEVDknKQIENGVSYTFHVY---
>UniRef50_B1V8Y8(1-160:165) Dihydrofolate reductase n=6 Tax=Candidatus Phytoplasma RepID=B1V8Y8_PHYAS  E=4e-31 s/c=0.84 id=30% cov=96%
MINLITAFDSNYLIGSDNKLPWHYPQDLHFFKKTTLNQEVLMGHQTYLSLKsyfkdKPFNFKKTYVAARNKGLQlDGCEVVFDLLTFLKtfLIQKKSHLFVIGGRQIYQQSLPFVDNLYITYILNRHKGNVYFPPVNWQDFQLIQKTIQPQ-------LIFAFYKRK
>UniRef50_Q96V60(1-149:176) Dihydrofolate reductase (Fragment) n=2 Tax=Pneumocystis carinii RepID=Q96V60_PNECA  E=2e-28 s/c=0.85 id=41% cov=78%
---LIVALTVSCGIGKGNALPWRLKSDMAYFKRVTSDvpvsdstkwmNVVLMGRKTWESLPerfRPLKGRINVVISRQEvlDLGQGTYHAKSLNDALVLLSciydtsssiQVNRIFVIGGAQLYKAAMehPRLDRIMATVIHKEIDCDVFFP---------------------------------
>UniRef50_D0WS26(2-140:184) Dihydrofolate reductase n=1 Tax=Actinomyces sp. oral taxon 848 str. F0332 RepID=D0WS26_9ACTO  E=3e-28 s/c=0.91 id=43% cov=81%
ILGAIWAQGRERAIGKDGALPWRLPEDLALFRRVTSGHPVIMGRKTWESLPprfRPLPGRRNIVLSRDPSFaADGAEAVRSLAEAAEAASHCEQAWIIGGAALYAEAVNVADVLVVTDVDVDVEGaDAFAPSI-------------------------------
>UniRef50_O62583(1-201:205) Dihydrofolate reductase n=1 Tax=Encephalitozoon cuniculi RepID=DYR_ENCCU  E=5e-24 s/c=0.56 id=37% cov=86%
MLALVVALASHRGIGNANALPWPRPlaADMAWFRTLSQsiplispdrialapsaSNAVVMGRRTWDSIPsrfRPLANRINVVLSRGPARSTENTFFIQTFEALDSlpLPPSSMTFVIGGRDVYSLALEsgRPHLIFATEVFESPECDVFFPHIDWASYEK------------------------
>UniRef50_A7XFK8(1-191:193) Frd dihydrofolate reductase n=3 Tax=unclassified T4-like viruses RepID=A7XFK8_9CAUD  E=4e-19 s/c=0.50 id=28% cov=99%
MIQCVFAIgdtkmsDENWAFGFKGGLPWgrPIKKDMENFKMRTMGDvelaAVVMGRNTFESLPKALEGRVNVVVSTDtskpapkakNGEQPDVYTAITNDGGLKELLEVIEklqglVSVIGGPSLIEKAVDFADRIVLTYVQRSGINDPF--EYDVGISKEMIQElYFDFVTKEEHNYFLdnyliseQILERK
>UniRef50_Q8MVZ8(1-130:260) Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Chlamydaster sterni RepID=Q8MVZ8_9EUKA  E=1e-17 s/c=0.70 id=30% cov=74%
----------------------------------------VMGRKTWESIPkkyRPLKDRLNVVISRTPtaisDLPASVLAFDCLEQALQIVDNIPviqDVYIVGGGQIYNEAIvhPRCTRIFLTHVRGiSPECDTFFPEL--KGWKLDKESGNVPDPEAPeVELNFCEYVR-
>UniRef50_Q9L6G3(17-129:133) Dihydrofolate reductase (Fragment) n=1 Tax=Lactococcus lactis RepID=Q9L6G3_9LACT  E=2e-16 s/c=0.77 id=26% cov=68%
---------------------------------------------------RVLPGRISIILTRDETYqseNEKVPIMHSPKEVLDWyYKQDKDLFITGGAEILALFESELELLYRAVVHEKFQGDTYFPtHFDFGKFKVVSEIFHDKDERNAYTFTIKKYEK-
>UniRef50_Q7Y267(1-149:195) Frd n=3 Tax=unclassified T4-like viruses RepID=Q7Y267_BPR69   E=2e-15 s/c=0.56 id=28% cov=73%
MLKLVFACApsktvddkLEYAFGLGDGLPWkHIKQDMSNFVARTKNTVMVMGAKTFASLPRLLPDRTHMVVTDMARKLPRTktdelarfyitqaefitlvmggeinLFSPSTDVPFKLSTEHVDVSVIGGPALLKQALPYADEIVMTKI--------------------------------------------
>UniRef50_B6H1X6(12-242:275) Pc13g03650 protein n=3 Tax=mitosporic Trichocomaceae RepID=B6H1X6_PENCW  E=4e-15 s/c=0.36 id=32% cov=79%
-LTLIVATTPIRtastttkeeitrlGIGLNGTLPWpRIKTDMSFFARVTsrpptpgTTNAIIMGRKTYDSVPgslRPLAKRINVVITRDTSGSvresvttelgnmrrkiaakaaqtqatnsekgtfdppkeaapadpmTDAIVTPSLGAALETLDSVyaaqgklGKIFVIGGAEIYNATLNMGAeelrgrpvRVVMTNVvrkgavgaSASFECDTFFP---------------------------------
>UniRef50_C1E922(108-271:287) Predicted protein n=1 Tax=Micromonas sp. RCC299 RepID=C1E922_9CHLO   E=2e-11 s/c=0.43 id=24% cov=65%
--------------------------------------AVLMGRRTFDQvaefvvrdkVPWPYEGKRVIVVSRTMTQKDvpeplsskVTVTAQSPSEALKALGKtgfTRRVYVDGGMTIRSLLeEDQVDEMVLTSVPVTIGRGTSLWGFDTKDkrdyrWSVTSSEP-------------------
>UniRef50_B3ETM7(8-139:183) Putative uncharacterized protein n=1 Tax=Candidatus Amoebophilus asiaticus 5a2 RepID=B3ETM7_AMOA5  E=5e-10 s/c=0.50 id=25% cov=28%
-----VAVSLDGFIAKqDGDIDWlslvdSPSEDYGYSAFMQGIDAVIMGRKTYD---------------------------------------------------------------------------------------------------------------
>UniRef50_A4XRV2(4-138:192) Bifunctional deaminase-reductase domain protein n=7 Tax=Pseudomonas aeruginosa group RepID=A4XRV2_PSEMY  E=2e-09 s/c=0.47 id=26% cov=38%
--TLIyhVTASLDGYIARpDGRLDWfdtpRQPDEeysFQYFYA--GIDALLMGRGTYEALlkrggPWPYPGKPCVVLTR-----------------------------------------------------------------------------------------------
>UniRef50_Q38V13(9-145:179) Putative dihydrofolate reductase n=1 Tax=Lactobacillus sakei subsp. sakei 23K RepID=Q38V13_LACSS  E=9e-09 s/c=0.45 id=22% cov=48%
--------------------------------------TIIMGRKTYEQCIKlagtyPYQEKQSYVFSKTLHDTADrtNVVTGNVPEFVRQLKaqDGGNIWLVGGAETFTMLLKaqLVDELIIT----------------------------------------------
>UniRef50_Q2SB85(3-134:175) Dihydrofolate reductase n=1 Tax=Hahella chejuensis KCTC 2396 RepID=Q2SB85_HAHCH  E=3e-08 s/c=0.45 id=19% cov=49%
--------------------------------------ALVMGSKTYLKVlelgAWPYEGKPVWVFSRQEDlkLAPGVERCagdPSTIVAHFRALDYKRVWLVGGGELLASFQeeDLVDEYIISYV--------------------------------------------
>UniRef50_A5FBH6(1-130:169) Putative uncharacterized protein n=1 Tax=Flavobacterium johnsoniae UW101 RepID=A5FBH6_FLAJ1  E=2e-06 s/c=0.42 id=25% cov=69%
METIIyVAVSANGLILLtseDNyQIPVELLQDcMGL--AHQTGN-MVIGLNTYRLFSnnanalEAFKGVEIAVLSSSCEEElEGVTVLKNIDAVREfyKAKGYSKIFVAGGAYTYQSFLKegHADEFYI-----------------------------------------------
>UniRef50_D0LSH2(10-136:184) Bifunctional deaminase-reductase domain protein n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LSH2_HALO1  E=4e-06 s/c=0.42 id=22% cov=42%
--------------------------------------ALLMGRRTYEVVaamdgDWPYGNRPVLVATHRPLDNAPRTVhavsgdIASMVETACQAAGERDVYIDGG-ELLRQALD------------------------------------------------------
>UniRef50_A8J1J4(17-141:151) Predicted protein (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8J1J4_CHLRE  E=2e-05 s/c=0.40 id=34% cov=28%
-----VAASVDGFIaGPNGSMDWLKPfedgTDYGYEQFLRGVGTVVMGRKTFE---------------------------------------------------------------------------------------------------------------
>UniRef50_A1R6A8(1-137:176) Riboflavin biosynthesis protein RibD n=1 Tax=Arthrobacter aurescens TC1 RepID=A1R6A8_ARTAT  E=0.0001 s/c=0.35 id=21% cov=48%
----------------------------------------IMGANTFREVSKMGGGSKVptYVVTHDQTLATKGrteLFSGDLRELVTRIKEsipqDKDICLFGGGGLVTEFveLGLIDELGLSII--------------------------------------------
