BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (159 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_P0ABQ5 Dihydrofolate reductase n=111 Tax=Enterobacteria...   333   1e-90
UniRef50_P27498 Dihydrofolate reductase n=89 Tax=Gammaproteobact...   303   1e-81
UniRef50_Q5R038 Dihydrofolate reductase n=3 Tax=Alteromonadales ...   181   5e-45
UniRef50_P43791 Dihydrofolate reductase n=19 Tax=Gammaproteobact...   175   4e-43
UniRef50_Q1LSS4 Dihydrofolate reductase n=1 Tax=Baumannia cicade...   175   4e-43
UniRef50_P12833 Dihydrofolate reductase type 3 n=26 Tax=Proteoba...   166   3e-40
UniRef50_D0KZ69 Dihydrofolate reductase n=2 Tax=Gammaproteobacte...   162   3e-39
UniRef50_Q15PF1 Dihydrofolate reductase n=18 Tax=Gammaproteobact...   160   2e-38
UniRef50_Q31I54 Dihydrofolate reductase n=32 Tax=Bacteria RepID=...   156   2e-37
UniRef50_D0U4K0 Dihydrofolate reductase n=2 Tax=uncultured SUP05...   155   4e-37
UniRef50_A3N0P3 Dihydrofolate reductase n=6 Tax=Pasteurellaceae ...   152   4e-36
UniRef50_Q494F1 Dihydrofolate reductase type I n=1 Tax=Candidatu...   151   7e-36
UniRef50_Q8D3H9 FolA protein n=1 Tax=Wigglesworthia glossinidia ...   151   8e-36
UniRef50_Q3JEI1 Dihydrofolate reductase n=3 Tax=Gammaproteobacte...   149   3e-35
UniRef50_Q89AV2 Dihydrofolate reductase n=5 Tax=Buchnera aphidic...   148   5e-35
UniRef50_P11045 Dihydrofolate reductase n=23 Tax=Firmicutes RepI...   146   2e-34
UniRef50_B8F4S8 Dihydrofolate reductase n=5 Tax=Pasteurellaceae ...   145   3e-34
UniRef50_A4Y040 Dihydrofolate reductase n=28 Tax=Proteobacteria ...   144   9e-34
UniRef50_UPI0001698640 dihydrofolate reductase n=1 Tax=Endorifti...   144   1e-33
UniRef50_Q0VM07 Dihydrofolate reductase n=5 Tax=Gammaproteobacte...   143   2e-33
UniRef50_A1U3D7 Dihydrofolate reductase n=6 Tax=Gammaproteobacte...   143   2e-33
UniRef50_C2FZ23 Dihydrofolate reductase n=2 Tax=Sphingobacterium...   142   4e-33
UniRef50_A9I779 FolA protein n=2 Tax=Bordetella RepID=A9I779_BORPD    142   5e-33
UniRef50_A9KH09 Dihydrofolate reductase n=8 Tax=Coxiella burneti...   140   9e-33
UniRef50_A4IUE2 Dihydrofolate reductase n=1 Tax=Yersinia ruckeri...   138   6e-32
UniRef50_UPI0001787F40 Dihydrofolate reductase n=1 Tax=Geobacill...   137   1e-31
UniRef50_A1AXR7 Dihydrofolate reductase n=6 Tax=Proteobacteria R...   137   1e-31
UniRef50_C6CYL9 Dihydrofolate reductase n=1 Tax=Paenibacillus sp...   137   2e-31
UniRef50_D2QJY0 Dihydrofolate reductase n=2 Tax=Bacteria RepID=D...   136   2e-31
UniRef50_Q3K556 Dihydrofolate reductase n=8 Tax=Bacteria RepID=Q...   134   8e-31
UniRef50_C7PKU6 Dihydrofolate reductase n=1 Tax=Chitinophaga pin...   133   2e-30
UniRef50_Q1LK80 Dihydrofolate reductase n=3 Tax=Proteobacteria R...   133   2e-30
UniRef50_A5CVJ7 Dihydrofolate reductase n=1 Tax=Candidatus Vesic...   132   4e-30
UniRef50_Q65IB5 DfrA n=4 Tax=Bacillaceae RepID=Q65IB5_BACLD           131   6e-30
UniRef50_B2I6E9 Dihydrofolate reductase n=11 Tax=Xanthomonadacea...   130   1e-29
UniRef50_Q2SXY8 Dihydrofolate reductase n=18 Tax=Proteobacteria ...   130   2e-29
UniRef50_Q2Y7L3 Dihydrofolate reductase n=7 Tax=Betaproteobacter...   130   2e-29
UniRef50_Q2W7P5 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q...   129   2e-29
UniRef50_A7HVX5 Dihydrofolate reductase n=13 Tax=Proteobacteria ...   129   3e-29
UniRef50_Q21NW4 Dihydrofolate reductase n=3 Tax=Bacteria RepID=Q...   128   5e-29
UniRef50_A6UB22 Dihydrofolate reductase n=18 Tax=Alphaproteobact...   128   6e-29
UniRef50_UPI0000E87D66 dihydrofolate reductase n=1 Tax=Methyloph...   128   6e-29
UniRef50_A5GBA2 Dihydrofolate reductase n=2 Tax=Geobacter RepID=...   127   9e-29
UniRef50_Q2K6G9 Dihydrofolate reductase protein n=3 Tax=Rhizobia...   127   1e-28
UniRef50_B8KL97 Dihydrofolate reductase n=1 Tax=gamma proteobact...   126   2e-28
UniRef50_C6W102 Dihydrofolate reductase n=1 Tax=Dyadobacter ferm...   126   2e-28
UniRef50_B3PTQ3 Dihydrofolate reductase protein n=49 Tax=Proteob...   126   2e-28
UniRef50_Q5X875 Dihydrofolate reductase FolA n=6 Tax=Legionella ...   126   3e-28
UniRef50_Q1CZU3 Dihydrofolate reductase n=1 Tax=Myxococcus xanth...   125   3e-28
UniRef50_Q1QUE0 Dihydrofolate reductase n=12 Tax=Bacteria RepID=...   125   3e-28
UniRef50_D1QNC5 Dihydrofolate reductase n=1 Tax=Prevotella oris ...   124   8e-28
UniRef50_Q67JQ2 Dihydrofolate reductase n=1 Tax=Symbiobacterium ...   124   9e-28
UniRef50_C0YTZ2 Possible dihydrofolate reductase type I involved...   124   1e-27
UniRef50_D0XKH5 Dihydrofolate reductase n=1 Tax=Brevundimonas su...   124   1e-27
UniRef50_B1XTJ0 Dihydrofolate reductase n=1 Tax=Polynucleobacter...   124   1e-27
UniRef50_A5EUV9 Dihydrofolate reductase n=1 Tax=Dichelobacter no...   123   2e-27
UniRef50_B0MUX5 Putative uncharacterized protein n=1 Tax=Alistip...   123   2e-27
UniRef50_B6INW3 Dihydrofolate reductase n=4 Tax=Alphaproteobacte...   123   2e-27
UniRef50_Q134B2 Dihydrofolate reductase n=10 Tax=Bradyrhizobiace...   122   4e-27
UniRef50_P04174 Dihydrofolate reductase n=33 Tax=Neisseriaceae R...   122   5e-27
UniRef50_C6X2F4 Dihydrofolate reductase n=20 Tax=Bacteroidetes R...   121   9e-27
UniRef50_A7Z5T2 DfrA n=2 Tax=Bacillaceae RepID=A7Z5T2_BACA2           120   1e-26
UniRef50_Q54277 Dihydrofolate reductase n=84 Tax=Bacilli RepID=D...   120   1e-26
UniRef50_Q7VQK5 Dihydrofolate reductase type I n=1 Tax=Candidatu...   120   1e-26
UniRef50_C6XMY9 Dihydrofolate reductase n=1 Tax=Hirschia baltica...   120   1e-26
UniRef50_A2SN57 Dihydrofolate reductase n=34 Tax=Burkholderiales...   120   2e-26
UniRef50_Q0SWS9 Dihydrofolate reductase n=1 Tax=Clostridium perf...   119   3e-26
UniRef50_C5CTW3 Dihydrofolate reductase n=1 Tax=Variovorax parad...   119   3e-26
UniRef50_B9XJM4 Dihydrofolate reductase n=1 Tax=bacterium Ellin5...   118   6e-26
UniRef50_Q5P234 Dihydrofolate reductase n=14 Tax=cellular organi...   118   7e-26
UniRef50_A0AJX9 DfrA protein n=15 Tax=Listeria RepID=A0AJX9_LISW6     118   7e-26
UniRef50_C1XJD1 Dihydrofolate reductase n=1 Tax=Meiothermus rube...   118   7e-26
UniRef50_B2SDZ8 Dihydrofolate reductase n=19 Tax=Francisella Rep...   117   1e-25
UniRef50_A0PY39 Dihydrofolate reductase n=3 Tax=Clostridium RepI...   117   1e-25
UniRef50_A4BS77 Dihydrofolate reductase n=1 Tax=Nitrococcus mobi...   117   1e-25
UniRef50_C8X9J8 Dihydrofolate reductase n=1 Tax=Nakamurella mult...   117   2e-25
UniRef50_B9ECC1 Putative uncharacterized protein n=1 Tax=Macroco...   116   2e-25
UniRef50_C7RLL7 Dihydrofolate reductase n=1 Tax=Candidatus Accum...   116   2e-25
UniRef50_Q5V600 Dihydrofolate reductase 2 n=1 Tax=Haloarcula mar...   116   3e-25
UniRef50_Q0C500 Dihydrofolate reductase n=4 Tax=Alphaproteobacte...   115   4e-25
UniRef50_Q9RR65 Dihydrofolate reductase n=2 Tax=Deinococcus RepI...   114   8e-25
UniRef50_D2QWB5 Dihydrofolate reductase n=1 Tax=Pirellula staley...   114   1e-24
UniRef50_Q04F50 Dihydrofolate reductase n=2 Tax=Oenococcus oeni ...   114   1e-24
UniRef50_UPI00016BFCBD Dihydrofolate reductase n=1 Tax=Epulopisc...   113   2e-24
UniRef50_Q18HG9 Dihydrofolate reductase n=4 Tax=Halobacteriaceae...   113   2e-24
UniRef50_B9LR90 Dihydrofolate reductase region n=2 Tax=Halobacte...   113   2e-24
UniRef50_C6W5S3 Dihydrofolate reductase n=1 Tax=Dyadobacter ferm...   112   3e-24
UniRef50_C6P459 Dihydrofolate reductase n=1 Tax=Sideroxydans lit...   112   3e-24
UniRef50_B2UP70 Dihydrofolate reductase n=1 Tax=Akkermansia muci...   112   3e-24
UniRef50_UPI0001C37DF3 dihydrofolate reductase n=1 Tax=Ruminococ...   112   5e-24
UniRef50_Q0TV23 Dihydrofolate reductase n=8 Tax=Clostridium perf...   111   6e-24
UniRef50_C3RMT4 Dihydrofolate reductase n=4 Tax=Bacteria RepID=C...   111   7e-24
UniRef50_D0VXF2 Putative uncharacterized protein dfrP n=1 Tax=Ba...   111   8e-24
UniRef50_A5FJX2 Dihydrofolate reductase n=1 Tax=Flavobacterium j...   110   1e-23
UniRef50_Q3BX85 Dihydrofolate reductase n=6 Tax=Xanthomonas RepI...   110   1e-23
UniRef50_Q13PE2 Dihydrofolate reductase n=1 Tax=Burkholderia xen...   110   2e-23
UniRef50_B0VHY5 Dihydrofolate reductase n=1 Tax=Candidatus Cloac...   110   2e-23
UniRef50_A2U3M8 Dihydrofolate reductase n=2 Tax=Polaribacter Rep...   110   2e-23
UniRef50_A7IF75 Dihydrofolate reductase n=3 Tax=Rhizobiales RepI...   110   2e-23
UniRef50_Q11US6 Dihydrofolate reductase n=1 Tax=Cytophaga hutchi...   109   2e-23
UniRef50_Q47IJ5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=Q...   109   3e-23
UniRef50_UPI00017452A7 Dihydrofolate reductase n=1 Tax=Verrucomi...   108   4e-23
UniRef50_Q5HFZ7 Dihydrofolate reductase n=54 Tax=Staphylococcus ...   108   5e-23
UniRef50_Q5HPB1 Dihydrofolate reductase n=24 Tax=Bacilli RepID=D...   108   5e-23
UniRef50_C1IBP0 Dihydrofolate reductase n=1 Tax=Clostridium sp. ...   108   5e-23
UniRef50_Q0AN20 Dihydrofolate reductase n=4 Tax=Alphaproteobacte...   108   7e-23
UniRef50_A3HTR7 Dihydrofolate reductase n=1 Tax=Algoriphagus sp....   107   1e-22
UniRef50_C1SJK6 Dihydrofolate reductase n=1 Tax=Denitrovibrio ac...   107   1e-22
UniRef50_B5EIA1 Dihydrofolate reductase region n=5 Tax=Geobacter...   107   2e-22
UniRef50_C0XLT5 Dihydrofolate reductase n=3 Tax=Lactobacillus Re...   106   2e-22
UniRef50_D0J8Z9 Dihydrofolate reductase n=2 Tax=Blattabacterium ...   106   3e-22
UniRef50_A6GQA5 Dihydrofolate reductase n=1 Tax=Limnobacter sp. ...   106   3e-22
UniRef50_B2TR57 Dihydrofolate reductase n=10 Tax=Clostridium Rep...   106   3e-22
UniRef50_C5NYS7 Dihydrofolate reductase n=1 Tax=Gemella haemolys...   106   3e-22
UniRef50_B3ER85 Putative uncharacterized protein n=1 Tax=Candida...   106   3e-22
UniRef50_C6XGC7 Dihydrofolate reductase protein n=1 Tax=Candidat...   105   3e-22
UniRef50_D0J2N2 Dihydrofolate reductase region n=3 Tax=Bacteria ...   105   4e-22
UniRef50_A0Z2N0 Dihydrofolate reductase n=2 Tax=unclassified Gam...   105   4e-22
UniRef50_A1VQZ7 Dihydrofolate reductase n=9 Tax=Bacteria RepID=A...   105   4e-22
UniRef50_C2MBL2 Dihydrofolate reductase n=1 Tax=Porphyromonas ue...   105   5e-22
UniRef50_Q3A0W8 Dihydrofolate reductase n=1 Tax=Pelobacter carbi...   105   5e-22
UniRef50_B2ICT5 Dihydrofolate reductase n=2 Tax=Beijerinckiaceae...   104   1e-21
UniRef50_C4FSY3 Putative uncharacterized protein n=1 Tax=Catonel...   104   1e-21
UniRef50_B4D395 Dihydrofolate reductase region n=1 Tax=Chthoniob...   103   2e-21
UniRef50_C9RIZ1 Dihydrofolate reductase n=1 Tax=Fibrobacter succ...   103   2e-21
UniRef50_B1MYC2 Dihydrofolate reductase n=3 Tax=Leuconostoc RepI...   103   3e-21
UniRef50_C3JBM5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=C...   102   3e-21
UniRef50_Q1GFV5 Dihydrofolate reductase n=18 Tax=Rhodobacterales...   102   6e-21
UniRef50_A8YUW1 Dihydrofolate reductase n=12 Tax=Lactobacillus R...   101   9e-21
UniRef50_D1BNV5 Dihydrofolate reductase region n=4 Tax=Veillonel...   100   1e-20
UniRef50_D1AYS8 Dihydrofolate reductase region n=1 Tax=Streptoba...   100   1e-20
UniRef50_Q6MID1 FolA protein n=1 Tax=Bdellovibrio bacteriovorus ...   100   2e-20
UniRef50_A6L1Q7 Dihydrofolate reductase n=34 Tax=Bacteroidales R...   100   2e-20
UniRef50_B8DW85 Dihydrofolate reductase n=6 Tax=Bifidobacterium ...   100   2e-20
UniRef50_B8HHJ9 Dihydrofolate reductase n=2 Tax=Micrococcineae R...   100   2e-20
UniRef50_Q54801 Dihydrofolate reductase n=65 Tax=Streptococcus R...   100   2e-20
UniRef50_C4L1C8 Dihydrofolate reductase region n=2 Tax=Exiguobac...   100   3e-20
UniRef50_Q03F97 Dihydrofolate reductase n=2 Tax=Pediococcus RepI...    99   5e-20
UniRef50_A3K5B9 Dihydrofolate reductase n=1 Tax=Sagittula stella...    99   5e-20
UniRef50_C7N8V9 Dihydrofolate reductase region n=5 Tax=Fusobacte...    99   6e-20
UniRef50_A1SJ32 Dihydrofolate reductase n=1 Tax=Nocardioides sp....    99   6e-20
UniRef50_Q59408 Dihydrofolate reductase type A13 n=57 Tax=Bacter...    99   6e-20
UniRef50_Q2S5H3 Dihydrofolate reductase n=3 Tax=cellular organis...    98   8e-20
UniRef50_Q7UIC9 Dihydrofolate reductase n=1 Tax=Rhodopirellula b...    98   1e-19
UniRef50_A1TM51 Dihydrofolate reductase n=4 Tax=cellular organis...    97   1e-19
UniRef50_A1WYQ0 Dihydrofolate reductase n=1 Tax=Halorhodospira h...    97   1e-19
UniRef50_UPI00016B2267 dihydrofolate reductase n=1 Tax=candidate...    97   2e-19
UniRef50_C4Z3U6 Dihydrofolate reductase n=8 Tax=Firmicutes RepID...    97   2e-19
UniRef50_C0QWN0 Dihydrofolate reductase n=2 Tax=Brachyspira RepI...    97   3e-19
UniRef50_A6WGF8 Dihydrofolate reductase n=5 Tax=Actinomycetales ...    96   3e-19
UniRef50_B7C7C2 Putative uncharacterized protein n=1 Tax=Eubacte...    96   4e-19
UniRef50_UPI0001874368 dihydrofolate reductase n=1 Tax=Corynebac...    96   5e-19
UniRef50_A5VJL0 Dihydrofolate reductase n=8 Tax=Lactobacillus Re...    96   5e-19
UniRef50_Q1WU16 Dihydrofolate reductase n=5 Tax=Lactobacillus Re...    95   6e-19
UniRef50_Q38WX9 Dihydrofolate reductase n=5 Tax=Lactobacillales ...    95   6e-19
UniRef50_C9BJS9 Dihydrofolate reductase n=13 Tax=Enterococcus Re...    95   7e-19
UniRef50_Q044A0 Dihydrofolate reductase n=13 Tax=Lactobacillus R...    94   1e-18
UniRef50_B9YFM0 Dihydrofolate reductase region n=3 Tax=Nostocace...    94   1e-18
UniRef50_A1WMP6 Dihydrofolate reductase n=2 Tax=Proteobacteria R...    94   1e-18
UniRef50_D2Q8R3 DfrA Dihydrofolate reductase n=12 Tax=Bifidobact...    94   2e-18
UniRef50_D2RRK6 Dihydrofolate reductase n=1 Tax=Haloterrigena tu...    94   2e-18
UniRef50_Q03S94 Dihydrofolate reductase n=4 Tax=Lactobacillus Re...    94   2e-18
UniRef50_C2HC06 Dihydrofolate reductase n=11 Tax=Enterococcus fa...    94   2e-18
UniRef50_Q3F0Y0 Dihydrofolate reductase n=2 Tax=Bacillus thuring...    93   2e-18
UniRef50_C3XD45 Dihydrofolate reductase n=2 Tax=Oxalobacter form...    93   3e-18
UniRef50_D1PWR8 Dihydrofolate reductase n=1 Tax=Prevotella berge...    93   3e-18
UniRef50_D1PCZ0 Dihydrofolate reductase n=1 Tax=Prevotella copri...    93   3e-18
UniRef50_P00380 Dihydrofolate reductase n=1 Tax=Enterococcus fae...    93   3e-18
UniRef50_B7H0P5 Dihydrofolate reductase type 3(Dihydrofolate red...    93   3e-18
UniRef50_C0EGY7 Putative uncharacterized protein n=1 Tax=Clostri...    92   4e-18
UniRef50_A0JZC8 Dihydrofolate reductase n=11 Tax=Bacteria RepID=...    92   5e-18
UniRef50_C7X688 Dihydrofolate reductase n=7 Tax=Bacteroidales Re...    92   5e-18
UniRef50_B6YRF0 Dihydrofolate reductase n=1 Tax=Candidatus Azoba...    92   6e-18
UniRef50_B6BUF2 Dihydrofolate reductase n=1 Tax=beta proteobacte...    92   8e-18
UniRef50_C5CC92 Dihydrofolate reductase n=3 Tax=Actinobacteria (...    92   8e-18
UniRef50_P15093 Dihydrofolate reductase n=3 Tax=Halobacteriaceae...    91   8e-18
UniRef50_Q5M5B2 Dihydrofolate reductase n=9 Tax=Streptococcus Re...    91   1e-17
UniRef50_Q934V0 Putative dihydrofolate reductase n=1 Tax=Salmone...    91   2e-17
UniRef50_C8NE93 Dihydrofolate reductase n=24 Tax=Lactobacillales...    91   2e-17
UniRef50_P11731 Dihydrofolate reductase type 5 n=27 Tax=Bacteria...    91   2e-17
UniRef50_A9HP20 Dihydrofolate reductase n=1 Tax=Roseobacter lito...    90   2e-17
UniRef50_Q9CBW1 Dihydrofolate reductase n=25 Tax=Actinomycetales...    90   2e-17
UniRef50_C7NFY1 Dihydrofolate reductase n=3 Tax=Actinomycetales ...    90   3e-17
UniRef50_B2GC42 Dihydrofolate reductase n=4 Tax=Lactobacillus Re...    89   3e-17
UniRef50_D2SDU7 Dihydrofolate reductase n=1 Tax=Geodermatophilus...    89   4e-17
UniRef50_Q5WDS2 Dihydrofolate reductase n=3 Tax=Bacillus RepID=Q...    89   4e-17
UniRef50_B3FJX9 Dihydrofolate reductase n=1 Tax=Pseudomonas phag...    89   6e-17
UniRef50_Q6CC38 YALI0C12771p n=1 Tax=Yarrowia lipolytica RepID=Q...    88   1e-16
UniRef50_A4VUL2 Dihydrofolate reductase n=9 Tax=Streptococcus Re...    87   2e-16
UniRef50_C8NZB9 Dihydrofolate reductase n=1 Tax=Erysipelothrix r...    87   2e-16
UniRef50_D2LGH8 Dihydrofolate reductase n=1 Tax=Rhodomicrobium v...    87   2e-16
UniRef50_C7R3F1 Dihydrofolate reductase n=1 Tax=Jonesia denitrif...    86   3e-16
UniRef50_C5BYZ5 Dihydrofolate reductase n=1 Tax=Beutenbergia cav...    86   3e-16
UniRef50_Q0G0R9 Dihydrofolate reductase n=2 Tax=Aurantimonadacea...    86   4e-16
UniRef50_B2GI60 Dihydrofolate reductase n=3 Tax=Actinomycetales ...    86   4e-16
UniRef50_C3PEY4 Dihydrofolate reductase n=9 Tax=Corynebacterium ...    86   4e-16
UniRef50_C7H0N2 Dihydrofolate reductase n=1 Tax=Eubacterium saph...    86   5e-16
UniRef50_P78218 Dihydrofolate reductase type 15 n=153 Tax=root R...    86   5e-16
UniRef50_C8WCM1 Dihydrofolate reductase region n=4 Tax=Zymomonas...    85   7e-16
UniRef50_Q8EV82 Dihyrofolate reductase n=1 Tax=Mycoplasma penetr...    85   8e-16
UniRef50_Q14P23 Putative dihydrofolate reductase oxidoreductase ...    85   8e-16
UniRef50_Q7NHQ9 Dihydrofolate reductase n=1 Tax=Gloeobacter viol...    84   1e-15
UniRef50_C9MLK6 Dihydrofolate reductase n=2 Tax=Prevotella RepID...    84   2e-15
UniRef50_B1V8Y8 Dihydrofolate reductase n=6 Tax=Candidatus Phyto...    84   2e-15
UniRef50_A4GI75 Dihydrofolate reductase n=1 Tax=uncultured marin...    84   2e-15
UniRef50_B7VPW7 Dihydrofolate reductase type I (Trimethoprim res...    84   2e-15
UniRef50_UPI0001926A4C PREDICTED: similar to Dihydrofolate reduc...    84   2e-15
UniRef50_C1C2C0 Dihydrofolate reductase n=1 Tax=Caligus clemensi...    84   2e-15
UniRef50_A6DQ18 Dihydrofolate reductase region n=1 Tax=Lentispha...    83   3e-15
UniRef50_Q59487 Dihydrofolate reductase n=17 Tax=Streptococcacea...    83   3e-15
UniRef50_Q8JKV3 Dihydrofolate reductase n=1 Tax=Heliothis zea vi...    82   5e-15
UniRef50_C5VBQ6 Dihydrofolate reductase n=5 Tax=Corynebacterium ...    82   5e-15
UniRef50_D1BYH5 Dihydrofolate reductase n=1 Tax=Xylanimonas cell...    82   5e-15
UniRef50_D0NVQ6 Putative uncharacterized protein n=1 Tax=Phytoph...    82   5e-15
UniRef50_C5RC79 Dihydrofolate reductase n=1 Tax=Weissella parame...    82   5e-15
UniRef50_C7P3D4 Dihydrofolate reductase region n=1 Tax=Halomicro...    82   6e-15
UniRef50_Q59397 Dihydrofolate reductase type 9 n=1 Tax=Escherich...    82   6e-15
UniRef50_C2CWT0 Dihydrofolate reductase n=1 Tax=Gardnerella vagi...    81   1e-14
UniRef50_D2NRG7 Dihydrofolate reductase n=2 Tax=Rothia mucilagin...    80   2e-14
UniRef50_C0VZ67 Possible dihydrofolate reductase n=3 Tax=Actinom...    80   2e-14
UniRef50_B3RI81 Putative uncharacterized protein n=1 Tax=Trichop...    80   2e-14
UniRef50_Q6BTR6 DEHA2C16456p n=2 Tax=Debaryomyces hansenii RepID...    80   2e-14
UniRef50_A8SNM7 Putative uncharacterized protein n=1 Tax=Parvimo...    79   3e-14
UniRef50_A5WHY1 Dihydrofolate reductase n=4 Tax=Moraxellaceae Re...    79   4e-14
UniRef50_UPI000186EC32 Dihydrofolate reductase, putative n=1 Tax...    79   4e-14
UniRef50_Q4JX60 FolA protein n=3 Tax=Corynebacterium RepID=Q4JX6...    79   4e-14
UniRef50_C3JYD2 Putative dihydrofolate reductase n=1 Tax=Pseudom...    79   4e-14
UniRef50_D0WS26 Dihydrofolate reductase n=1 Tax=Actinomyces sp. ...    79   4e-14
UniRef50_B9YC91 Putative uncharacterized protein n=1 Tax=Holdema...    79   5e-14
UniRef50_C7XU42 Dihydrofolate reductase n=1 Tax=Lactobacillus co...    79   6e-14
UniRef50_Q96V60 Dihydrofolate reductase (Fragment) n=2 Tax=Pneum...    79   7e-14
UniRef50_C4G1L6 Putative uncharacterized protein n=1 Tax=Abiotro...    78   8e-14
UniRef50_Q6A328 Dihydrofolate reductase n=1 Tax=Pasteurella mult...    78   9e-14
UniRef50_Q937I9 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q...    78   1e-13
UniRef50_Q0FG98 Dihydrofolate reductase n=1 Tax=Rhodobacterales ...    78   1e-13
UniRef50_P27422 Dihydrofolate reductase type 7 n=46 Tax=Bacteria...    77   1e-13
UniRef50_B0MRL8 Putative uncharacterized protein n=1 Tax=Eubacte...    77   1e-13
UniRef50_P16184 Dihydrofolate reductase n=38 Tax=Pneumocystis Re...    77   2e-13
UniRef50_C4Z7Z2 Dihydrofolate reductase n=34 Tax=Bacteria RepID=...    77   2e-13
UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraure...    77   2e-13
UniRef50_C2KQT3 Possible dihydrofolate reductase n=2 Tax=Mobilun...    76   4e-13
UniRef50_C4LHD2 Bifunctional dihydrofolate reductase-thymidylate...    75   6e-13
UniRef50_P0ABQ7 Dihydrofolate reductase type 8 n=2 Tax=Enterobac...    75   7e-13
UniRef50_Q8SDF8 PHIKZ004 n=1 Tax=Pseudomonas phage phiKZ RepID=Q...    75   1e-12
UniRef50_B6AE97 Thymidylate synthase family protein n=4 Tax=cell...    74   1e-12
UniRef50_A7SCT0 Predicted protein n=2 Tax=Nematostella vectensis...    74   1e-12
UniRef50_Q5V3R2 Dihydrofolate reductase 1 n=1 Tax=Haloarcula mar...    74   1e-12
UniRef50_A3DES9 Dihydrofolate reductase n=5 Tax=Clostridium RepI...    74   2e-12
UniRef50_C0VSW2 Dihydrofolate reductase n=2 Tax=Corynebacterium ...    74   2e-12
UniRef50_Q6F181 Dihydrofolate reductase n=1 Tax=Mesoplasma floru...    73   2e-12

>UniRef50_P0ABQ5 Dihydrofolate reductase n=111 Tax=Enterobacteriaceae
           RepID=DYR_ECOL6
          Length = 159

 Score =  333 bits (853), Expect = 1e-90,   Method: Compositional matrix adjust.
 Identities = 159/159 (100%), Positives = 159/159 (100%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159


>UniRef50_P27498 Dihydrofolate reductase n=89 Tax=Gammaproteobacteria
           RepID=DYR_KLEAE
          Length = 159

 Score =  303 bits (777), Expect = 1e-81,   Method: Compositional matrix adjust.
 Identities = 142/159 (89%), Positives = 152/159 (95%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAAL VDRVIGMENAMPWNL  DLAWFKRNTLNKPV+MGR TWESIGRPLPGRKNI
Sbjct: 1   MISLIAALRVDRVIGMENAMPWNLNEDLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SS+PG+DDRV WV SV+EAIAACGDV EIMVIGGGRVY++FLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSKPGSDDRVQWVSSVEEAIAACGDVEEIMVIGGGRVYDEFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDY+PD+WESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR 159


>UniRef50_Q5R038 Dihydrofolate reductase n=3 Tax=Alteromonadales RepID=Q5R038_IDILO
          Length = 166

 Score =  181 bits (460), Expect = 5e-45,   Method: Compositional matrix adjust.
 Identities = 86/162 (53%), Positives = 118/162 (72%), Gaps = 5/162 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISL+ A+A +RVIG +N MPW+LP +L +FK+ TL KP++MGR T+ESIGRPLPGRKNI+
Sbjct: 3   ISLVVAMADNRVIGKDNKMPWHLPDELQYFKKITLGKPIVMGRRTFESIGRPLPGRKNIV 62

Query: 62  LSSQP----GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           LS +       D +V WV  V +AIAA G V E+M+IGGG++YE+FLP A +LY+T I+ 
Sbjct: 63  LSRRTDRSENQDSQVVWVSGVQQAIAAAGPVEELMIIGGGKIYEKFLPLADRLYVTKIEL 122

Query: 118 EVEGDTHFPDY-EPDDWESVFSEFHDADAQNSHSYCFEILER 158
            VEGDT+FPDY +  DW+ +  +   AD +NSH++   I +R
Sbjct: 123 NVEGDTYFPDYHQVADWQEIERQNFAADERNSHNFSTLIFDR 164


>UniRef50_P43791 Dihydrofolate reductase n=19 Tax=Gammaproteobacteria
           RepID=DYR_HAEIN
          Length = 160

 Score =  175 bits (444), Expect = 4e-43,   Method: Compositional matrix adjust.
 Identities = 84/158 (53%), Positives = 107/158 (67%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
            SLI A  ++ VIG +N MPW+LPADLAWF++NT  KPVIMGR T+ESIGRPLP R NI+
Sbjct: 3   FSLIVATTLNNVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           LS Q    + V W  S + A+    D  EIM+IGGG +++Q+LPKA KLYLT I  E++G
Sbjct: 63  LSRQLFEHEGVIWKDSFESAVNFVRDFDEIMLIGGGELFKQYLPKADKLYLTQIQTELDG 122

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DT FP    ++WE  F E+  AD QN +   F IL R+
Sbjct: 123 DTFFPQLNWEEWEIEFDEYRKADEQNRYDCRFLILTRK 160


>UniRef50_Q1LSS4 Dihydrofolate reductase n=1 Tax=Baumannia cicadellinicola str. Hc
           (Homalodisca coagulata) RepID=Q1LSS4_BAUCH
          Length = 165

 Score =  175 bits (444), Expect = 4e-43,   Method: Compositional matrix adjust.
 Identities = 81/160 (50%), Positives = 112/160 (70%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAA+ VDR+IG++N MPW+L  DL WFK++T NKPVIMGR T+++I +PL GR NI
Sbjct: 2   IISLIAAMTVDRIIGIKNTMPWHLYDDLIWFKKHTNNKPVIMGRKTFDAIKKPLSGRLNI 61

Query: 61  ILSSQ--PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +LS    P  D  + WV +  +A+ A G+V E+MVIGG ++Y  F+ +A +LYLTHID  
Sbjct: 62  VLSRNFIPSRDQDIIWVDNPIKALIAAGNVTEVMVIGGAQIYNIFILQAHRLYLTHIDIN 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           ++GDT FP Y  + W   F ++H+   +N   Y FEILER
Sbjct: 122 IKGDTWFPHYHTNQWRVTFRKYHNDQEKNLPRYYFEILER 161


>UniRef50_P12833 Dihydrofolate reductase type 3 n=26 Tax=Proteobacteria
           RepID=DYR3_SALTY
          Length = 162

 Score =  166 bits (419), Expect = 3e-40,   Method: Compositional matrix adjust.
 Identities = 82/160 (51%), Positives = 112/160 (70%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA + +IG +N +PW+LPADL  FK  TL KPV+MGR T+ESIGRPLPGR+N+
Sbjct: 2   LISLIAALAHNNLIGKDNLIPWHLPADLRHFKAVTLGKPVVMGRRTFESIGRPLPGRRNV 61

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S  P    + V    S+D A+A   D  E M+IGGG++Y + LP+A +LYLT+IDA++
Sbjct: 62  VVSRNPQWQAEGVEVAPSLDAALALLTDCEEAMIIGGGQLYAEALPRADRLYLTYIDAQL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GDTHFPDY    W+ +    H AD +NS++  F  L R+
Sbjct: 122 NGDTHFPDYLSLGWQELERSTHPADDKNSYACEFVTLSRQ 161


>UniRef50_D0KZ69 Dihydrofolate reductase n=2 Tax=Gammaproteobacteria
           RepID=D0KZ69_HALNC
          Length = 177

 Score =  162 bits (410), Expect = 3e-39,   Method: Compositional matrix adjust.
 Identities = 82/159 (51%), Positives = 104/159 (65%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I L+AAL  ++VIG  NA+PW+LPADL  FK+ T+ KP+IMGR T++SIGRPLPGRKNI+
Sbjct: 3   IGLVAALTRNQVIGRYNALPWSLPADLQRFKKITMGKPIIMGRKTYDSIGRPLPGRKNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119
           +S  P    D VT V S+D A+ A    PE+MVIGG  +Y QFLP+A +LY T +   + 
Sbjct: 63  ISRNPDFHADGVTVVDSLDMALEAADQAPEVMVIGGANIYYQFLPRADRLYFTLVHTTID 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GD  FP Y   DW  V  E H ADA N   Y F   +R
Sbjct: 123 DGDAFFPAYNRRDWRLVIEENHPADADNPFPYSFMTWQR 161


>UniRef50_Q15PF1 Dihydrofolate reductase n=18 Tax=Gammaproteobacteria
           RepID=Q15PF1_PSEA6
          Length = 171

 Score =  160 bits (404), Expect = 2e-38,   Method: Compositional matrix adjust.
 Identities = 83/168 (49%), Positives = 110/168 (65%), Gaps = 11/168 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+++AA+A  RVIG+ N MPW++PADL  FKR TL KP++MGR T+ESIGR LPGR NI+
Sbjct: 4   IAMVAAMANQRVIGLNNQMPWHMPADLKHFKRITLGKPIVMGRKTYESIGRALPGRLNIV 63

Query: 62  LSS-QPGTDDRVTWVKSVDEAIAACGD------VP----EIMVIGGGRVYEQFLPKAQKL 110
           ++S Q       + V S ++AIA          +P    E+MVIGGG VY+ FLP A +L
Sbjct: 64  ITSDQNYQLADASIVHSCEQAIAVATSHMQNDGMPEHDQEVMVIGGGTVYQHFLPHANRL 123

Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           YLT ID +  GDT+FP+Y    W+ + SE +D D +N HSY F  L R
Sbjct: 124 YLTFIDLDTPGDTYFPNYSDGAWQEIESESNDPDEKNPHSYRFVTLAR 171


>UniRef50_Q31I54 Dihydrofolate reductase n=32 Tax=Bacteria RepID=Q31I54_THICR
          Length = 175

 Score =  156 bits (394), Expect = 2e-37,   Method: Compositional matrix adjust.
 Identities = 74/160 (46%), Positives = 113/160 (70%), Gaps = 2/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           IS+IAA+   R+IG +N MPW+LP DL +FK NT+NKPVIMGR T+ESIG +PLP R+N+
Sbjct: 14  ISMIAAMDKHRIIGADNDMPWHLPDDLKFFKANTVNKPVIMGRKTFESIGSKPLPNRRNL 73

Query: 61  ILSSQPGTDDRVTWV-KSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++     +     V  S +EA+ +C    EI+++GGG++Y Q +P A KLY+T +DAEV
Sbjct: 74  VITRNDAYEANGAEVFHSAEEALKSCKSEVEIIIMGGGQLYAQMMPFANKLYVTLVDAEV 133

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GDT FP++  D+W+ +  E+HD D ++++++ F  L R+
Sbjct: 134 AGDTTFPEWLTDEWQEISKEWHDKDERHAYAFEFVTLIRK 173


>UniRef50_D0U4K0 Dihydrofolate reductase n=2 Tax=uncultured SUP05 cluster bacterium
           RepID=D0U4K0_9GAMM
          Length = 179

 Score =  155 bits (392), Expect = 4e-37,   Method: Compositional matrix adjust.
 Identities = 72/158 (45%), Positives = 102/158 (64%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A+  +++IG  NA+PW+LPADL +FK+ T  K V+MGR T+ESIGRPLP R+N+I
Sbjct: 21  LSIIVAMDDNQLIGKNNALPWHLPADLGYFKKVTTGKTVLMGRKTYESIGRPLPNRRNVI 80

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S       D    V S+D A+    D  E+MV+GG   YEQ LP   +LY+T I+ E +
Sbjct: 81  VSRNTNFKADGCEVVSSIDAALKLAKDDSEVMVMGGASFYEQMLPSVDRLYITQIEGEYQ 140

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD HFP ++   +  V  E H AD +N ++Y F IL+R
Sbjct: 141 GDAHFPKFDRGKFSEVSRESHTADEKNQYTYHFTILDR 178


>UniRef50_A3N0P3 Dihydrofolate reductase n=6 Tax=Pasteurellaceae RepID=A3N0P3_ACTP2
          Length = 162

 Score =  152 bits (384), Expect = 4e-36,   Method: Compositional matrix adjust.
 Identities = 79/161 (49%), Positives = 106/161 (65%), Gaps = 4/161 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A  ++ VIG EN MPWNLP DLAWF++NTL KPVIMGR T+ESIGR LP R NII
Sbjct: 3   ISLIVARTLNHVIGKENQMPWNLPVDLAWFRQNTLGKPVIMGRKTYESIGRLLPKRPNII 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LS      +     ++  +A        +  EIMVIGGG +++Q +P+A +LYLT I AE
Sbjct: 63  LSRSGFCVEGAYTAQNFAQAAELAETFANTDEIMVIGGGELFKQTIPQADRLYLTEIQAE 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +EGDT F +++  +W  V  ++ + D QN++   F ILER+
Sbjct: 123 IEGDTLF-EFDESNWTLVEEKWSEIDEQNAYRCRFMILERK 162


>UniRef50_Q494F1 Dihydrofolate reductase type I n=1 Tax=Candidatus Blochmannia
           pennsylvanicus str. BPEN RepID=Q494F1_BLOPB
          Length = 164

 Score =  151 bits (382), Expect = 7e-36,   Method: Compositional matrix adjust.
 Identities = 76/162 (46%), Positives = 107/162 (66%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           +ISLIAAL  + +IG +N +PW LP D+ WFK +TL KP+IMGR T+ESIG +PL  R N
Sbjct: 2   IISLIAALTTNHIIGKKNVIPWYLPIDIKWFKYHTLYKPIIMGRKTFESIGKKPLLNRLN 61

Query: 60  IILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID-- 116
           I+LS     + + V   +++DEA++   D  E+MVIGG  +Y  FLP+AQ+LYLT+I   
Sbjct: 62  IVLSRNLLNNYNGVFIAENIDEALSLIQDAYEVMVIGGSEIYNVFLPRAQRLYLTYIHNM 121

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            E++GD  FPDY+  +W+S+F+ F+           F ILER
Sbjct: 122 VEIDGDILFPDYDIREWKSIFNSFYKVREDCFCYLHFSILER 163


>UniRef50_Q8D3H9 FolA protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of
           Glossina brevipalpis RepID=Q8D3H9_WIGBR
          Length = 162

 Score =  151 bits (381), Expect = 8e-36,   Method: Compositional matrix adjust.
 Identities = 70/159 (44%), Positives = 103/159 (64%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A + ++VIG +  +PWNLP D++WFK+NT+NKPVIMGR T+ESI +PL  R NI+
Sbjct: 3   ISLIWAQSKNKVIGHDQYIPWNLPEDISWFKKNTINKPVIMGRKTFESIKKPLENRINIV 62

Query: 62  LSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           LS     +    +   K+  +A+    +  E+M+IGG ++Y+ FLPKA KLYLT I+AE+
Sbjct: 63  LSKNLYRNVMSNLKIAKNPKQALFFAKNYNEVMIIGGKQIYKIFLPKATKLYLTVINAEI 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            G+  FP Y    W   F ++ ++D +N +S  F I  +
Sbjct: 123 NGNIFFPRYNRKKWILSFEKYFNSDTKNKYSMYFRIFNK 161


>UniRef50_Q3JEI1 Dihydrofolate reductase n=3 Tax=Gammaproteobacteria
           RepID=Q3JEI1_NITOC
          Length = 165

 Score =  149 bits (376), Expect = 3e-35,   Method: Compositional matrix adjust.
 Identities = 71/159 (44%), Positives = 103/159 (64%), Gaps = 1/159 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS I A+  + +IG    +PW+LPADL +F+R T+ KP++MGR T E+IGRPLPGR NI
Sbjct: 2   IISFIVAMDENHLIGANRRLPWHLPADLKYFRRMTMGKPMLMGRSTHEAIGRPLPGRHNI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++  P       T V +V+  + A G+  E+ VIGG  +YEQ LP+A+++YLT +    
Sbjct: 62  VVTHNPDYKAPGCTVVHTVEAGLQAAGEAEEVTVIGGASLYEQLLPQARRIYLTLVRGHF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GDT FP ++P  W  V+ E +D D QN + Y F  LER
Sbjct: 122 QGDTWFPAFDPGTWVEVWREDYDPDPQNPYPYSFIRLER 160


>UniRef50_Q89AV2 Dihydrofolate reductase n=5 Tax=Buchnera aphidicola RepID=DYR_BUCBP
          Length = 164

 Score =  148 bits (374), Expect = 5e-35,   Method: Compositional matrix adjust.
 Identities = 70/160 (43%), Positives = 102/160 (63%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A++ + VIG +N++PWN+P DL+WFK++T+ K +IMGR TWESIGR LP R+NI+
Sbjct: 3   ISIIVAMSQNLVIGQKNSIPWNIPKDLSWFKKHTIKKSIIMGRKTWESIGRVLPMRQNIV 62

Query: 62  LSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+ Q    +  V +V S+ +AI +     EIM+IGG  +Y Q L  A KLY+THI+  + 
Sbjct: 63  LTRQKNIKNTNVLFVNSISKAIQSALYKNEIMIIGGSNLYNQMLTSANKLYITHIEKYIL 122

Query: 121 GDTHFPDYEPDDW--ESVFSEFHDADAQNSHSYCFEILER 158
           GDT+FP Y+   W              +NS    F+IL++
Sbjct: 123 GDTYFPTYDHLPWKIIFKKKIIEHEKTKNSFYVTFKILKK 162


>UniRef50_P11045 Dihydrofolate reductase n=23 Tax=Firmicutes RepID=DYR_BACSU
          Length = 168

 Score =  146 bits (368), Expect = 2e-34,   Method: Compositional matrix adjust.
 Identities = 70/160 (43%), Positives = 103/160 (64%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS I A+  +R+IG +N +PW+LP DLA+FK+ T    +IMGR T+ESIGRPLP RKNI
Sbjct: 1   MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGRKTFESIGRPLPNRKNI 60

Query: 61  ILSSQPGTDDR-VTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++S P ++ +  T V S+ + +  C    E  VIGG ++Y    P A +LY+T I  E 
Sbjct: 61  VVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYTDLFPYADRLYMTKIHHEF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD HFP+++  +W+ V SE    D +N + Y F + E++
Sbjct: 121 EGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK 160


>UniRef50_B8F4S8 Dihydrofolate reductase n=5 Tax=Pasteurellaceae RepID=B8F4S8_HAEPS
          Length = 165

 Score =  145 bits (367), Expect = 3e-34,   Method: Compositional matrix adjust.
 Identities = 74/160 (46%), Positives = 105/160 (65%), Gaps = 4/160 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A  +++VIG +NAM W+LP DLAWF+ NTL KPVIMGR T+ESIGR LP R NII
Sbjct: 3   ISVIVARTLNKVIGKDNAMLWHLPVDLAWFRENTLGKPVIMGRKTYESIGRLLPKRPNII 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVP---EIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LS      D      S+++A+    +     EIM++GGG +++Q +P A KLYLT I A 
Sbjct: 63  LSRSGFAIDGAYSAISLEQAVELAKNFANSDEIMILGGGELFKQTMPFADKLYLTEIQAN 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +EGDT F +++   W+ +  ++ + D QNS+   F IL++
Sbjct: 123 IEGDTFF-EFDETQWQQIAEKWSEIDEQNSYRCRFMILDK 161


>UniRef50_A4Y040 Dihydrofolate reductase n=28 Tax=Proteobacteria RepID=A4Y040_PSEMY
          Length = 176

 Score =  144 bits (363), Expect = 9e-34,   Method: Compositional matrix adjust.
 Identities = 80/165 (48%), Positives = 104/165 (63%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAALA +RVIG +N +PW+LPADL  FK  TL KP+IMGR TW+S+GRPLPGR NI+
Sbjct: 11  LSLIAALADNRVIGRDNQLPWHLPADLKHFKALTLGKPIIMGRKTWDSLGRPLPGRLNIV 70

Query: 62  LSSQPG-TDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S Q G T +      +++EAI      A   D  E+M+IGG ++YE  L +A +LYLT 
Sbjct: 71  VSRQAGLTLEGAEVFATLEEAIKRADAWAREEDAEELMLIGGAQLYELGLEQADRLYLTR 130

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +  E EGD  FP  +   W    S  H A A+    Y FE+ ERR
Sbjct: 131 VGLEPEGDAFFPQIDESAWRMTSSVEHPASAETPF-YAFEVWERR 174


>UniRef50_UPI0001698640 dihydrofolate reductase n=1 Tax=Endoriftia persephone
           'Hot96_1+Hot96_2' RepID=UPI0001698640
          Length = 158

 Score =  144 bits (362), Expect = 1e-33,   Method: Compositional matrix adjust.
 Identities = 71/147 (48%), Positives = 97/147 (65%), Gaps = 1/147 (0%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67
           +A +RVIG  N MPW+LPADL  FK  T+ KP++MGR TWES+   LP R +I+++  P 
Sbjct: 1   MARNRVIGRHNRMPWHLPADLRHFKALTIGKPIVMGRKTWESLPGLLPDRPHIVVTHNPS 60

Query: 68  T-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126
              +  T V S+DEAIAA G+V EIMV+GGG  Y + LP+  ++YLT +DAE EGDT FP
Sbjct: 61  YYAEGCTLVHSIDEAIAAAGEVEEIMVVGGGAFYAEILPRVGRIYLTLVDAEFEGDTLFP 120

Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCF 153
           D +  +W     E H AD ++++ Y  
Sbjct: 121 DLDMAEWLECSRERHPADEKHTYPYSL 147


>UniRef50_Q0VM07 Dihydrofolate reductase n=5 Tax=Gammaproteobacteria
           RepID=Q0VM07_ALCBS
          Length = 171

 Score =  143 bits (361), Expect = 2e-33,   Method: Compositional matrix adjust.
 Identities = 70/165 (42%), Positives = 101/165 (61%), Gaps = 7/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S++ A A + VIG  N +PW LP DL +FK+ T  KPVIMGR TWES+  PLPGR NI+
Sbjct: 7   LSMMVAKATNNVIGRNNKLPWYLPNDLKYFKQVTFGKPVIMGRKTWESLKGPLPGRTNIV 66

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVP------EIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++ QP    +    V +VD+AI    +V       E +++GG  +Y   L + Q+LYLT 
Sbjct: 67  ITRQPAYQAEGAKVVATVDDAITMAENVAFIEGQEEAVIMGGAEIYALALAQTQRLYLTE 126

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + AEV+GDT FP+Y+  +WE +  E   A+  N + Y F + ER+
Sbjct: 127 VHAEVDGDTFFPEYDKGEWEEIAREDFPAEGPNPYDYSFVVYERK 171


>UniRef50_A1U3D7 Dihydrofolate reductase n=6 Tax=Gammaproteobacteria
           RepID=A1U3D7_MARAV
          Length = 171

 Score =  143 bits (361), Expect = 2e-33,   Method: Compositional matrix adjust.
 Identities = 72/166 (43%), Positives = 103/166 (62%), Gaps = 12/166 (7%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           +LI A+A +RVIG  N +PW LP DL +FK+ T+ KP+IMGR TW+SIGRPLPGR N+++
Sbjct: 4   ALIVAMARNRVIGRNNKLPWYLPGDLRYFKQATMGKPIIMGRKTWDSIGRPLPGRMNVVI 63

Query: 63  SSQP------GTDDRVT----WVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112
           S  P      GT    +     VK+  +A    GD  E+M+IGGG++Y + LP   ++Y+
Sbjct: 64  SRNPEWQAPAGTVAAASLNEALVKAEAQANLEGGD--EVMIIGGGQIYAEALPMVDRIYI 121

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           T + AEV+GD  FP+   D+WE +  E   A   N + Y F + +R
Sbjct: 122 TQVHAEVDGDAFFPEVNWDEWEEIGREDFSASDNNPYDYSFVVYQR 167


>UniRef50_C2FZ23 Dihydrofolate reductase n=2 Tax=Sphingobacterium spiritivorum
           RepID=C2FZ23_9SPHI
          Length = 164

 Score =  142 bits (357), Expect = 4e-33,   Method: Compositional matrix adjust.
 Identities = 71/159 (44%), Positives = 98/159 (61%), Gaps = 1/159 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+LI A A + VIG +N MPW+LP D  +FK+NTL   VIMGR T+E+IG+ LP R+NI+
Sbjct: 6   ITLIVAAAENNVIGKDNQMPWHLPNDFKYFKKNTLEHSVIMGRKTFEAIGKALPDRRNIV 65

Query: 62  LS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S +Q      V    S+ EAI  C D  E+ VIGG  +YEQ LP A K+ LT +   +E
Sbjct: 66  ISRNQDFHHPDVDTANSLQEAILYCRDEREVFVIGGANIYEQTLPFAHKVLLTRVHTTIE 125

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GD  FP   P++W     E H AD +++  Y F++  R+
Sbjct: 126 GDAVFPVLNPEEWMLESEEKHFADDKHAFDYTFQVFNRK 164


>UniRef50_A9I779 FolA protein n=2 Tax=Bordetella RepID=A9I779_BORPD
          Length = 178

 Score =  142 bits (357), Expect = 5e-33,   Method: Compositional matrix adjust.
 Identities = 71/163 (43%), Positives = 98/163 (60%), Gaps = 11/163 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++L+ A + +RVIG +N +PW LP DLA FKR TL  P+IMGR TWES+GRPLPGR N++
Sbjct: 21  LTLVVAYSDNRVIGRDNTLPWKLPGDLAHFKRTTLGSPIIMGRKTWESLGRPLPGRTNVV 80

Query: 62  LS-----SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +S     + PG     T V ++  A+ ACGD P+  VIGG ++Y Q LP A ++  T + 
Sbjct: 81  ISRNLRYAAPG----ATVVPTLQAAVEACGDAPDAYVIGGAQIYAQALPLAARVIATEVH 136

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           A VEGD  FP      W    +      A+N + Y F + ER+
Sbjct: 137 AHVEGDAFFPYLPSFAWRE--ASRQPQPAENGYDYDFVVYERQ 177


>UniRef50_A9KH09 Dihydrofolate reductase n=8 Tax=Coxiella burnetii
           RepID=A9KH09_COXBN
          Length = 161

 Score =  140 bits (354), Expect = 9e-33,   Method: Compositional matrix adjust.
 Identities = 69/160 (43%), Positives = 107/160 (66%), Gaps = 3/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +I+LIAA+  +R+IG  N +PW+LPADLA FK  TL KP++MGR T++SIG+PLP R+NI
Sbjct: 2   IITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSIGKPLPHRRNI 61

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++ Q     +      S+D+A++A    PE+++IGG R++++ LPKA K+ LT I+   
Sbjct: 62  VITQQKNLIIEGCDIFYSLDDALSALTKEPEVIIIGGARIFKEALPKADKMILTIINHSF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD +FP++   +W+      H+ D +N   Y F+ LE R
Sbjct: 122 EGDVYFPEWNDKEWKITSQIKHERDEKN--PYPFQFLELR 159


>UniRef50_A4IUE2 Dihydrofolate reductase n=1 Tax=Yersinia ruckeri RepID=A4IUE2_YERRU
          Length = 191

 Score =  138 bits (347), Expect = 6e-32,   Method: Compositional matrix adjust.
 Identities = 70/164 (42%), Positives = 101/164 (61%), Gaps = 13/164 (7%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLI A+A +  IG +NA+PW+LP DL + K++T+ KP++MGR T++SIGRPLPGR N+
Sbjct: 27  IISLILAMADNGTIGDKNALPWHLPNDLQFLKKSTMGKPIVMGRKTYQSIGRPLPGRTNV 86

Query: 61  ILSSQ------PGTDDRVTWVKSVDEAIAACG---DVPEIMVIGGGRVYEQFLPKAQKLY 111
           ++S        PG          +  AIAA     +V EIM++GG ++Y   LP   +LY
Sbjct: 87  VISRSLEKEALPG----CLIYSDLSVAIAALKKEPEVEEIMIMGGAQIYRAALPMMDRLY 142

Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEI 155
           LTH+ A +EGDT  P ++      +F E H  D +N + Y FEI
Sbjct: 143 LTHVHANIEGDTQMPPFDFSHATLIFEEKHFKDEKNRYDYTFEI 186


>UniRef50_UPI0001787F40 Dihydrofolate reductase n=1 Tax=Geobacillus sp. Y412MC10
           RepID=UPI0001787F40
          Length = 162

 Score =  137 bits (345), Expect = 1e-31,   Method: Compositional matrix adjust.
 Identities = 71/163 (43%), Positives = 103/163 (63%), Gaps = 5/163 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MIS+I A+  D+VIG+   MPW LP D+A+FK  TL+K ++MGR TW+S G +PLP RKN
Sbjct: 1   MISMIWAMGKDQVIGLNGTMPWRLPRDMAFFKEKTLHKTILMGRKTWDSFGGKPLPHRKN 60

Query: 60  IILSSQPG---TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+L+       T+D+   +  ++ A+    +  E+MVIGG ++YE  LPKA +LY T ID
Sbjct: 61  IVLTRDESFTLTEDQGIVIHDIENALPYSKN-EELMVIGGSQIYELMLPKADRLYCTFID 119

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
              EGDT+FP+   D+W+ V       D +N ++Y F   ER+
Sbjct: 120 ESFEGDTYFPEVNWDEWKIVEEVPGITDEKNPYAYRFVTFERK 162


>UniRef50_A1AXR7 Dihydrofolate reductase n=6 Tax=Proteobacteria RepID=A1AXR7_RUTMC
          Length = 163

 Score =  137 bits (345), Expect = 1e-31,   Method: Compositional matrix adjust.
 Identities = 62/158 (39%), Positives = 102/158 (64%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A+  +++IG  NA+PW LPADLA+FK+ T+ K V+MGR T++SIGRPL  R+NII
Sbjct: 3   LSIIVAMDDNQLIGKNNALPWYLPADLAYFKKTTIGKAVLMGRKTYDSIGRPLSNRRNII 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S       D    V S++ A+       E+M++GG   YEQ + K  ++Y+T ++ + +
Sbjct: 63  VSRNTKLKVDGCEVVGSINVALNLVNGANELMIMGGVSFYEQMIDKVDRIYITEVNGKFD 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT+FP+++   +  +  E H  D +N H++ F IL++
Sbjct: 123 GDTYFPEFDRTKFSELSRESHQPDEKNLHAHNFVILQK 160


>UniRef50_C6CYL9 Dihydrofolate reductase n=1 Tax=Paenibacillus sp. JDR-2
           RepID=C6CYL9_PAESJ
          Length = 163

 Score =  137 bits (344), Expect = 2e-31,   Method: Compositional matrix adjust.
 Identities = 69/160 (43%), Positives = 102/160 (63%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+   R IG+ N +PW LPA++A+F R+T  K V+MGR T+ES+ +PL  R N++
Sbjct: 3   ITMIAAMDRGRTIGIGNKLPWRLPAEMAYFTRHTTGKAVVMGRKTFESLPKPLKDRTNVV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++ QP    +    V SV EAI   G+  E+MVIGG  +Y QFLP A K+ LT +D  +E
Sbjct: 63  ITRQPEYAKEGCEVVHSVQEAIDRYGE-GELMVIGGADIYAQFLPFADKIRLTEVDTNIE 121

Query: 121 -GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GD  FP +   +WE V +E  ++D +N+ S+ F+   RR
Sbjct: 122 GGDAFFPTFNEGEWERVDAEKVESDERNAFSFTFQTFARR 161


>UniRef50_D2QJY0 Dihydrofolate reductase n=2 Tax=Bacteria RepID=D2QJY0_9SPHI
          Length = 163

 Score =  136 bits (343), Expect = 2e-31,   Method: Compositional matrix adjust.
 Identities = 71/160 (44%), Positives = 104/160 (65%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAA+A + VIG EN +PW+LP D A+FKR T + P+IMGR + ES+G+PLP R NI+
Sbjct: 3   ISLIAAVAQNGVIGRENDLPWHLPDDFAFFKRKTSHHPIIMGRKSLESLGKPLPNRTNIV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           L+     +   VT V ++D+AIA    +   EI VIGG  +Y+  LP A  LYLT I  +
Sbjct: 63  LTRNAEFSAAGVTIVHTLDDAIAEAKAINQTEIFVIGGAEIYKMALPIATTLYLTEIHQD 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            +GD +FP+++ ++W+ V    H AD +++ S+ F   E+
Sbjct: 123 YDGDAYFPEFDKNEWQEVSRRPHPADERHAVSFDFVEYEK 162


>UniRef50_Q3K556 Dihydrofolate reductase n=8 Tax=Bacteria RepID=Q3K556_PSEPF
          Length = 170

 Score =  134 bits (338), Expect = 8e-31,   Method: Compositional matrix adjust.
 Identities = 70/164 (42%), Positives = 106/164 (64%), Gaps = 8/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAAL  +RVIG++N+MPW+LP D  +FK  TL KP+IMGR TW+S+GRPLPGR NI+
Sbjct: 7   LSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNIV 66

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S Q G   +      S++ A+    +      V E+M+IGG ++Y Q L +A +LYLT 
Sbjct: 67  VSRQAGLVLEGAEVYPSLEAAVVRAEEWAKDQGVDELMLIGGAQLYAQGLAQADRLYLTR 126

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +    EGD  FP+++ + W+ V +  + A+  +  +Y FE+ E+
Sbjct: 127 VALSPEGDAWFPEFDLNQWKLVSNVPNPAEG-DKPAYNFEVWEK 169


>UniRef50_C7PKU6 Dihydrofolate reductase n=1 Tax=Chitinophaga pinensis DSM 2588
           RepID=C7PKU6_CHIPD
          Length = 164

 Score =  133 bits (334), Expect = 2e-30,   Method: Compositional matrix adjust.
 Identities = 62/160 (38%), Positives = 104/160 (65%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A + + VIG+ N +PW+LP D+ +FK  T+ KP++MGR ++E +GR LPGR NI+
Sbjct: 3   LSIIVAASENNVIGINNHLPWHLPVDMKYFKDTTMGKPIVMGRKSFEELGRVLPGRPNIM 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++ Q   T + +  V S++  I  A      EI V GGG +++  L    ++YLT + A 
Sbjct: 63  ITRQKDYTAEGLHIVPSLEAGIEKAKTFGTEEIFVTGGGEIFKMALSIVDRVYLTRVHAT 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           V+GDT+FP+++P  W+ V +E H+ D +++H+  F++ ER
Sbjct: 123 VQGDTYFPEFDPRGWKLVKNERHEKDEKHAHALTFQVWER 162


>UniRef50_Q1LK80 Dihydrofolate reductase n=3 Tax=Proteobacteria RepID=Q1LK80_RALME
          Length = 166

 Score =  133 bits (334), Expect = 2e-30,   Method: Compositional matrix adjust.
 Identities = 68/163 (41%), Positives = 95/163 (58%), Gaps = 10/163 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +++LI A A + VIG  N +PW LP DL  FKR T+  P+IMGR TW+SIGRPLPGR+NI
Sbjct: 3   LLTLIVARARNGVIGRNNTLPWRLPEDLQHFKRTTMGAPIIMGRKTWDSIGRPLPGRRNI 62

Query: 61  ILSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           +++        G D     V S+++A   C    ++ +IGG ++Y + LP A +L +T I
Sbjct: 63  VVTRNRDLHIEGAD----VVGSIEDAQRLCIGAEQVFLIGGAQLYAEALPSADRLIVTEI 118

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           DA+VEGD  FP  +   W     E H ++  N   Y F   ER
Sbjct: 119 DADVEGDAFFPAVDRTTWVETARELHHSET-NGFDYAFVTYER 160


>UniRef50_A5CVJ7 Dihydrofolate reductase n=1 Tax=Candidatus Vesicomyosocius okutanii
           HA RepID=A5CVJ7_VESOH
          Length = 163

 Score =  132 bits (332), Expect = 4e-30,   Method: Compositional matrix adjust.
 Identities = 60/158 (37%), Positives = 100/158 (63%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A+  + +IG +N++PW LPADLA+FK+ T+ K ++MGR T +SIGR LP R+NII
Sbjct: 3   LSIIVAMDDNYLIGKDNSLPWYLPADLAYFKKITIGKTILMGRKTHDSIGRSLPNRRNII 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S       D    V S+D A++   +  E+M++GG   Y+Q + K  +LY+T +    +
Sbjct: 63  VSKNTKFKADNCEVVSSIDVALSLANNDNELMIVGGSSFYDQIIDKVDRLYITEVKGMFD 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD +FP+++   +  +  E H  D +N ++Y F +L+R
Sbjct: 123 GDAYFPEFDRTKFIELSRESHKPDEKNFYTYNFIVLQR 160


>UniRef50_Q65IB5 DfrA n=4 Tax=Bacillaceae RepID=Q65IB5_BACLD
          Length = 162

 Score =  131 bits (330), Expect = 6e-30,   Method: Compositional matrix adjust.
 Identities = 72/161 (44%), Positives = 98/161 (60%), Gaps = 2/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAA+  +R+IG +N +PW+LP DL +FK  T    VIMGR T+ESIGRPLP R+NI
Sbjct: 1   MISLIAAMDRNRLIGKDNDLPWHLPQDLKYFKEVTKGHAVIMGRKTFESIGRPLPHRENI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIA-ACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           I++S    D      + S +EA+  A     E  VIGG  +Y + LP A KLY+T ID  
Sbjct: 61  IVTSNKELDIPNCQVMHSAEEAVRFAKNRNEECFVIGGSTLYTEILPFADKLYVTKIDET 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD +FP++   +WE V       D +N + Y F + +R+
Sbjct: 121 FEGDRYFPEFSEAEWEIVSRRKGLKDDKNPYDYEFLVYQRK 161


>UniRef50_B2I6E9 Dihydrofolate reductase n=11 Tax=Xanthomonadaceae
           RepID=B2I6E9_XYLF2
          Length = 188

 Score =  130 bits (327), Expect = 1e-29,   Method: Compositional matrix adjust.
 Identities = 72/159 (45%), Positives = 98/159 (61%), Gaps = 8/159 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++SLIAAL   R IG +N +PW+LP DL  FK  TL +PV+MGR T  S+GRPLPGR N+
Sbjct: 24  IVSLIAALDRYRAIGRDNGLPWHLPDDLKRFKALTLGRPVLMGRKTAHSLGRPLPGRTNL 83

Query: 61  ILSSQ---PGTDDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           +L+     P ++ R   V S+D AI  AA      + VIGGG +Y   LP A  +YLTH+
Sbjct: 84  VLTRSGHVPFSEMRA--VDSLDAAIVQAAAEGADTLSVIGGGELYALTLPHANAMYLTHV 141

Query: 116 DAEVEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCF 153
           D  V G DT+FP ++  DWE    E H  D ++++ + F
Sbjct: 142 DVAVAGADTYFPMFDAVDWEIKNREPHQGDGRHAYPFTF 180


>UniRef50_Q2SXY8 Dihydrofolate reductase n=18 Tax=Proteobacteria RepID=Q2SXY8_BURTA
          Length = 219

 Score =  130 bits (327), Expect = 2e-29,   Method: Compositional matrix adjust.
 Identities = 67/161 (41%), Positives = 95/161 (59%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 56  LTLIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 115

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D      S+ +A+A        E  +IGG ++Y + L  A KL +T ID +
Sbjct: 116 VTRDAARRFDGCDTATSLGDALALAERDGAAEAFLIGGAQLYAEGLRHADKLIVTEIDQD 175

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD  FP  +P  WE+V  + H A   N  +Y F +  R+
Sbjct: 176 FEGDASFPAPDPAQWEAVSRDAHRAAPPNDFAYAFVVYRRK 216


>UniRef50_Q2Y7L3 Dihydrofolate reductase n=7 Tax=Betaproteobacteria
           RepID=Q2Y7L3_NITMU
          Length = 183

 Score =  130 bits (326), Expect = 2e-29,   Method: Compositional matrix adjust.
 Identities = 70/169 (41%), Positives = 102/169 (60%), Gaps = 14/169 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S++ A+A +R IG +NA+PW+LP DL  FK  T+  P+IMGR T+ESIGR LPGR +II
Sbjct: 5   LSVLVAMARNRAIGHKNAIPWHLPHDLKHFKELTMGHPMIMGRKTYESIGRLLPGRTSII 64

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDV-----------PEIMVIGGGRVYEQFLPKAQK 109
           ++ QP  +      V S+ EA++AC  +            E  VIGG  +++Q LP   +
Sbjct: 65  ITRQPDYEVPGALVVSSIGEALSACKQIRSGEEGHPDQGNECFVIGGADIFQQMLPLCDR 124

Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           LY+T I  + EGDT+FP+++ +DW  V  E H  D+     Y F  L+R
Sbjct: 125 LYMTEIHRDFEGDTYFPEFDRNDWWEVSREEHVDDS--GLEYHFVTLDR 171


>UniRef50_Q2W7P5 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q2W7P5_MAGSA
          Length = 175

 Score =  129 bits (325), Expect = 2e-29,   Method: Compositional matrix adjust.
 Identities = 73/162 (45%), Positives = 99/162 (61%), Gaps = 9/162 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A+A + VIG +NA+PW++P DL WFK NTL KPVIMGR TWESIGRPLP R NI+
Sbjct: 17  VALIVAVAANGVIGKDNALPWHIPEDLKWFKENTLGKPVIMGRKTWESIGRPLPKRPNIV 76

Query: 62  LSSQPG-TDDRVTWVKSVD----EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++ Q G   +      S+D     A     +  E+MVIGG  ++ + LP A++LYLT I 
Sbjct: 77  VTRQTGWRAEGAHTAHSLDEALALAARLAPEAAELMVIGGNSLFAEALPGARRLYLTEIA 136

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              EGDT FP +E   W  V    ++ D     ++ F IL+R
Sbjct: 137 RAYEGDTMFPAFERGLWHEVSRRRNEGDP----AFDFVILDR 174


>UniRef50_A7HVX5 Dihydrofolate reductase n=13 Tax=Proteobacteria RepID=A7HVX5_PARL1
          Length = 169

 Score =  129 bits (324), Expect = 3e-29,   Method: Compositional matrix adjust.
 Identities = 66/165 (40%), Positives = 99/165 (60%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           +S + A+A + VIG +N++PW L  D+A+FKR T+ KPVIMGR TWES+ R PLPGR NI
Sbjct: 3   VSYVVAIADNGVIGRDNSLPWRLSGDMAFFKRITMGKPVIMGRKTWESLPRKPLPGRPNI 62

Query: 61  ILSSQP-----GTDDRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++        G +   + V+++     +A+     E+MVIGG ++Y +    A +LY+T
Sbjct: 63  VVTRDAQYEAEGAEIAASAVEALRRGRELASASGADEVMVIGGAQLYAEMFDDATRLYIT 122

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            + A  EGD  FP ++   W  V  E H A  ++S  Y F +LER
Sbjct: 123 EVHAAPEGDVSFPAFDAAHWREVSRERHKAGEKDSADYSFVVLER 167


>UniRef50_Q21NW4 Dihydrofolate reductase n=3 Tax=Bacteria RepID=Q21NW4_SACD2
          Length = 171

 Score =  128 bits (322), Expect = 5e-29,   Method: Compositional matrix adjust.
 Identities = 66/169 (39%), Positives = 101/169 (59%), Gaps = 11/169 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + ++ A A + VIG+ N +PW + ADL  FK+ T+  P+IMGR T++SIG+PLPGR  I+
Sbjct: 3   LVIVVAAAQNGVIGINNTLPWRISADLQHFKQVTIGHPIIMGRKTYDSIGKPLPGRTTIV 62

Query: 62  LSSQP-----GTDDRVTWVKSVD------EAIAACGDVPEIMVIGGGRVYEQFLPKAQKL 110
           ++ Q      G +D+V    S++      E IAA   V E M++GG ++Y Q L +  K+
Sbjct: 63  VTRQADWQAEGYEDQVKVAYSLEGAMELAEQIAAQMGVAEAMLVGGAQLYRQALERVSKV 122

Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +LT + AE+EGD  FP+ + + W  V    + AD +N + Y F  L RR
Sbjct: 123 HLTRVHAEIEGDAWFPELDGNIWAEVQCVRYKADEKNEYDYSFVELHRR 171


>UniRef50_A6UB22 Dihydrofolate reductase n=18 Tax=Alphaproteobacteria
           RepID=A6UB22_SINMW
          Length = 187

 Score =  128 bits (322), Expect = 6e-29,   Method: Compositional matrix adjust.
 Identities = 69/165 (41%), Positives = 96/165 (58%), Gaps = 7/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I ++ A+A++ VIG E  +PW LP DL  FK  T+ KPVIMGR TW +IGRPLPGR NI+
Sbjct: 14  IVIVVAVALNGVIGREGDLPWRLPTDLKRFKAQTIGKPVIMGRKTWAAIGRPLPGRPNIV 73

Query: 62  LSSQ-----PGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++       PG +    +    +V    AA     EI VIGGG +Y Q +  A  L++T 
Sbjct: 74  VTRNRAFEAPGAEVAPSLEAALAVARERAAAIGADEICVIGGGEIYRQSIGMADVLHVTE 133

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + AEV+GDT FP+ +P  +E V  E   +  ++SH+  F    RR
Sbjct: 134 VQAEVDGDTRFPEIDPAVFEKVLEEDLQSGEKDSHAMHFVTWRRR 178


>UniRef50_UPI0000E87D66 dihydrofolate reductase n=1 Tax=Methylophilales bacterium HTCC2181
           RepID=UPI0000E87D66
          Length = 161

 Score =  128 bits (321), Expect = 6e-29,   Method: Compositional matrix adjust.
 Identities = 59/139 (42%), Positives = 90/139 (64%), Gaps = 1/139 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A++ + VIG+ N +PW++P DL  FK  T+  P++MGR T++SIGRPLPGRKNI+
Sbjct: 4   ISIIVAMSNNNVIGINNTLPWHIPQDLKRFKSLTMGNPIVMGRKTFDSIGRPLPGRKNIV 63

Query: 62  LS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++ ++    + V  V S++  +A   D   + VIGG ++Y+ FL  A  LY+T +D++V 
Sbjct: 64  ITRNEDSIIEGVEIVNSINSLLALIKDEEHVFVIGGEQIYKIFLDHATHLYVTEVDSDVA 123

Query: 121 GDTHFPDYEPDDWESVFSE 139
           GD HFP      W+ V  E
Sbjct: 124 GDAHFPKLSTSQWKEVGRE 142


>UniRef50_A5GBA2 Dihydrofolate reductase n=2 Tax=Geobacter RepID=A5GBA2_GEOUR
          Length = 163

 Score =  127 bits (320), Expect = 9e-29,   Method: Compositional matrix adjust.
 Identities = 69/160 (43%), Positives = 99/160 (61%), Gaps = 6/160 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAA+A +RVIG  NA+PW++PAD   F+  TL  PVIMGR T+ES+  PLPGRKNI
Sbjct: 2   VISLIAAMAENRVIGRNNAIPWDIPADRKRFRALTLGHPVIMGRKTFESLAGPLPGRKNI 61

Query: 61  ILSSQPGTDDRVTWVK-SVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++ Q        ++   +  A+A  G+  EI + GGG +Y Q LP A ++YLT I +  
Sbjct: 62  IITRQMDYRAEGCFIAHDLASALAMAGETDEIFICGGGEIYRQALPIADRIYLTIIHSRF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP+  P+ +  V  E      +N+  Y F + ++R
Sbjct: 122 DGDTRFPEI-PERFVEVGRE----TVENAIPYSFVLYDKR 156


>UniRef50_Q2K6G9 Dihydrofolate reductase protein n=3 Tax=Rhizobiales
           RepID=Q2K6G9_RHIEC
          Length = 172

 Score =  127 bits (320), Expect = 1e-28,   Method: Compositional matrix adjust.
 Identities = 65/164 (39%), Positives = 101/164 (61%), Gaps = 7/164 (4%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           ++IAA+A +  IG E  MPW L +DL  FK  TL KPV+MGR T++SIG+PLPGR N+++
Sbjct: 7   TIIAAVARNGTIGREGDMPWRLSSDLKRFKTLTLGKPVVMGRRTYDSIGKPLPGRPNVVI 66

Query: 63  SSQPGTDDR-VTWVKSVDEAIAACGDVP------EIMVIGGGRVYEQFLPKAQKLYLTHI 115
           S Q   D   ++   S+ EA+ A   +       EI +IGGG++Y Q +  A ++Y+TH+
Sbjct: 67  SRQAAIDHSDISMAHSLAEALEAAERLALQTGAGEICIIGGGQIYAQAIDLADRMYITHV 126

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +A+++GD  FP  +P  W++       A  ++S+   F + ERR
Sbjct: 127 EADLDGDAFFPAIDPGTWQAGEVVAVPAGERDSYPTRFVVYERR 170


>UniRef50_B8KL97 Dihydrofolate reductase n=1 Tax=gamma proteobacterium NOR5-3
           RepID=B8KL97_9GAMM
          Length = 182

 Score =  126 bits (317), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 67/159 (42%), Positives = 98/159 (61%), Gaps = 8/159 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+LI A A + VIG +NA+PW LP DLA FKR T+ KP++MGR T+ESIGRPLPGR NI+
Sbjct: 6   IALIVAAADNDVIGRDNALPWQLPGDLAHFKRTTMGKPILMGRLTYESIGRPLPGRTNIV 65

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVP------EIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S  PG +   V  V+S+++A+    D+       E+M+IGG ++Y   LP A ++YLT 
Sbjct: 66  ISRDPGYSAAGVRSVQSLEKALELAKDIAVIDGSSELMIIGGAQIYALALPLASRIYLTR 125

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQ-NSHSYC 152
           +  E  GD   P  +   W+    + + AD    +H++ 
Sbjct: 126 VHVEPAGDAFLPAIDWAHWKESGRQENPADGSVPAHTFL 164


>UniRef50_C6W102 Dihydrofolate reductase n=1 Tax=Dyadobacter fermentans DSM 18053
           RepID=C6W102_DYAFD
          Length = 167

 Score =  126 bits (317), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 62/156 (39%), Positives = 100/156 (64%), Gaps = 4/156 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+IAA++ + VIG+ N++PW+LP + A F++ T  K  IMGR ++E+        +N+I
Sbjct: 7   LSIIAAMSENHVIGLNNSLPWHLPDEWAHFRKVTAGKAFIMGRKSFEAPDALHSEYRNVI 66

Query: 62  LSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S+P    + RV + + +  AIA   D  ++ V+GG  V+EQ LP A ++YLT + A+V
Sbjct: 67  ITSRPPAQAEPRVEYARDISGAIALLSDETDVFVLGGASVFEQMLPLADRMYLTIVHAQV 126

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEI 155
           EGD  FP ++ DDW+   SEFH AD  + H+Y F +
Sbjct: 127 EGDAFFPAFDSDDWQLADSEFHGAD--DDHAYAFSM 160


>UniRef50_B3PTQ3 Dihydrofolate reductase protein n=49 Tax=Proteobacteria
           RepID=B3PTQ3_RHIE6
          Length = 172

 Score =  126 bits (317), Expect = 2e-28,   Method: Compositional matrix adjust.
 Identities = 64/164 (39%), Positives = 103/164 (62%), Gaps = 7/164 (4%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           ++IAA+A + +IG +  MPW L +DL  FK  TL KPV+MGR T++SIG+PLPGR N+++
Sbjct: 7   TIIAAVARNGIIGRDGDMPWRLSSDLKRFKALTLGKPVVMGRKTYDSIGKPLPGRPNVVI 66

Query: 63  SSQPGTDD-RVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           S Q   D   V    S+ EA+ A         V EI ++GGG++Y Q +  A ++ +TH+
Sbjct: 67  SRQAAIDHPDVAMAHSLAEAMDAAERLARETGVDEICIVGGGQIYAQAINLADRMCITHV 126

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +A+++GD  FPD +PD W++  +    A  ++S+   + + +RR
Sbjct: 127 EADLDGDASFPDIDPDLWQAAETIAVPAGEKDSYPTRYVVYKRR 170


>UniRef50_Q5X875 Dihydrofolate reductase FolA n=6 Tax=Legionella RepID=Q5X875_LEGPA
          Length = 163

 Score =  126 bits (316), Expect = 3e-28,   Method: Compositional matrix adjust.
 Identities = 64/158 (40%), Positives = 89/158 (56%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAA+     +G+ N +   LPADL  FK  T+ KP+IMGR T+ESIG+PLPGR NI
Sbjct: 3   LISLIAAIDETGGLGINNQLLCYLPADLQHFKSITMGKPIIMGRKTYESIGKPLPGRLNI 62

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++S    +   V  V S+ +AI    D  E+M+IGG ++Y Q +  A +LY+T I  +  
Sbjct: 63  VISQSIQSIPGVVVVDSLGQAIKETADASEVMIIGGAKIYSQAISIANRLYITRIHHQFM 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            D  FP      W     E+   D +N +   F I ER
Sbjct: 123 ADVFFPKINELVWSCRSKEYRQHDNKNQYDMTFCIYER 160


>UniRef50_Q1CZU3 Dihydrofolate reductase n=1 Tax=Myxococcus xanthus DK 1622
           RepID=Q1CZU3_MYXXD
          Length = 159

 Score =  125 bits (315), Expect = 3e-28,   Method: Compositional matrix adjust.
 Identities = 71/158 (44%), Positives = 96/158 (60%), Gaps = 14/158 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S I A+A +RVIG  N +PW LPADLA FKR T+   ++MGR T+ESIGRPLPGR  I+
Sbjct: 3   LSAIVAMAANRVIGAGNQLPWRLPADLARFKRITMGHTLVMGRKTYESIGRPLPGRTFIV 62

Query: 62  LSSQ-----PGTDDRVTWVKSVDEAIA---ACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           ++ Q     PG    V    SVDEA++   A GD  E+ + GG  +Y Q + + Q++YLT
Sbjct: 63  VTRQRDFAPPG----VQVAHSVDEALSLAKASGD-SEVFIAGGADLYAQTMDRVQRIYLT 117

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSY 151
           HI     GDT FPD +   W  V  + H  DA+  H++
Sbjct: 118 HIARNFPGDTWFPDVDLSGWTCVEEQAH-PDAEPPHTF 154


>UniRef50_Q1QUE0 Dihydrofolate reductase n=12 Tax=Bacteria RepID=Q1QUE0_CHRSD
          Length = 195

 Score =  125 bits (315), Expect = 3e-28,   Method: Compositional matrix adjust.
 Identities = 63/142 (44%), Positives = 94/142 (66%), Gaps = 9/142 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+L+AA++ +RVIG++N +PW+LP DL +FK  T++KP++MGR T+ESIGRPLPGR NI+
Sbjct: 19  IALVAAMSRNRVIGVDNKLPWHLPEDLKFFKAVTMSKPLVMGRKTFESIGRPLPGRLNIV 78

Query: 62  LSSQPG---TDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112
           ++   G     D +     +  A+      A    V +I VIGGG ++ + LP A +LYL
Sbjct: 79  VTRDRGYAQDHDGIRVCHDLASALDMADGQAIIDGVEDICVIGGGEIFAEALPCATRLYL 138

Query: 113 THIDAEVEGDTHFPDYEPDDWE 134
           T +D EVEGD  FP ++  +W+
Sbjct: 139 TEVDIEVEGDAWFPAFDAREWQ 160


>UniRef50_D1QNC5 Dihydrofolate reductase n=1 Tax=Prevotella oris F0302
           RepID=D1QNC5_9BACT
          Length = 160

 Score =  124 bits (312), Expect = 8e-28,   Method: Compositional matrix adjust.
 Identities = 67/161 (41%), Positives = 96/161 (59%), Gaps = 4/161 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59
           ++SLIAA+A +R IG +N + +++  DL  FKR T+   VIMGRHT+ES+    LP RKN
Sbjct: 2   ILSLIAAVARNRAIGYQNRLLFHIKTDLEHFKRLTMGHVVIMGRHTFESLPNGALPHRKN 61

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++S    +    T V S  EA+  C    E+ VIGG +VY++ + +A +LYLT IDA  
Sbjct: 62  IVISKSVASFHGCTRVSSFKEALDMCQTEEEVFVIGGEQVYKEAITQADRLYLTEIDALA 121

Query: 120 E-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E  D +FPDY  + W  V  E H     N  ++ F + +RR
Sbjct: 122 EQADAYFPDY--NSWHLVAHEAHKKSEDNPFAFAFTVYQRR 160


>UniRef50_Q67JQ2 Dihydrofolate reductase n=1 Tax=Symbiobacterium thermophilum
           RepID=Q67JQ2_SYMTH
          Length = 165

 Score =  124 bits (311), Expect = 9e-28,   Method: Compositional matrix adjust.
 Identities = 67/153 (43%), Positives = 89/153 (58%), Gaps = 4/153 (2%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67
           +  +R IG E  +PW LPA++  F+R T+ K V+MGR T+ESIG PL GR NI+L+  PG
Sbjct: 1   MGRNRAIGREGRLPWRLPAEMRHFRRTTMGKAVVMGRRTYESIGGPLKGRTNIVLTRDPG 60

Query: 68  TDDRVTWVK-SVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126
                  V+ SV E +    D   + VIGG  VY QFLP A ++ LT ID + EGD  FP
Sbjct: 61  FRAPGCEVRHSVAELLQ---DRRPLYVIGGAEVYRQFLPHADEMILTRIDHDFEGDAFFP 117

Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +  D+WE V S  H  D +N + +  E   RR
Sbjct: 118 AWSEDEWELVGSTPHPRDEENPYDFVVEHYRRR 150


>UniRef50_C0YTZ2 Possible dihydrofolate reductase type I involved in trimethoprim
           resistance n=1 Tax=Chryseobacterium gleum ATCC 35910
           RepID=C0YTZ2_9FLAO
          Length = 165

 Score =  124 bits (311), Expect = 1e-27,   Method: Compositional matrix adjust.
 Identities = 61/160 (38%), Positives = 93/160 (58%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M +++ A+     IG EN + W+LP DL  FK  T   PVIMGR T+ESIG+ LP R NI
Sbjct: 1   MTTIVVAMGEKNEIGFENQLLWHLPKDLKHFKEITSGHPVIMGRKTYESIGKALPNRTNI 60

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++S +    ++ +  V S+ EA+     +  E+ VIGGG +YEQ +    +L +T + A+
Sbjct: 61  VVSRKKDWFEEGILIVGSIKEALKFAKKIDEEVFVIGGGNIYEQTMDVVDRLEVTLVKAD 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +E DT FP  +P  W+      H+ D +N + +CF+  ER
Sbjct: 121 LEADTFFPKIDPKIWKMTNEICHEKDEKNGYDFCFQTFER 160


>UniRef50_D0XKH5 Dihydrofolate reductase n=1 Tax=Brevundimonas subvibrioides ATCC
           15264 RepID=D0XKH5_9CAUL
          Length = 175

 Score =  124 bits (310), Expect = 1e-27,   Method: Compositional matrix adjust.
 Identities = 68/169 (40%), Positives = 99/169 (58%), Gaps = 12/169 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           I+L+ A A + VIG +  +PW L +DL  FK+ TL KP IMGR TWES+  RPLPGR N+
Sbjct: 6   IALVVARARNGVIGRDGDLPWKLRSDLQRFKQITLGKPCIMGRSTWESLPLRPLPGRLNL 65

Query: 61  ILSSQPGTDDR---------VTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQK 109
           +LS     ++R              ++D A     D  + EI VIGG  ++E  LP+A++
Sbjct: 66  VLSRDLSYEERGKAKGAVVCSNLADAIDMARETAEDDGIDEICVIGGTALFEAALPRAKR 125

Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           LY+T ++AE EGD  FP ++   +    +E HDA  ++ H + F IL+R
Sbjct: 126 LYITEVEAEPEGDALFPAFDESLFAETLNERHDAGEKDDHPFVFRILDR 174


>UniRef50_B1XTJ0 Dihydrofolate reductase n=1 Tax=Polynucleobacter necessarius subsp.
           necessarius STIR1 RepID=B1XTJ0_POLNS
          Length = 162

 Score =  124 bits (310), Expect = 1e-27,   Method: Compositional matrix adjust.
 Identities = 65/139 (46%), Positives = 90/139 (64%), Gaps = 6/139 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A + + VIG +N MPW + ADL +FKR T+  PVIMGR TWESIGR LPGR+NI+
Sbjct: 6   ISMIVARSRNHVIGRDNQMPWKISADLQFFKRVTMGHPVIMGRKTWESIGRSLPGRRNIV 65

Query: 62  LS---SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +S   S P +   +  V S+DEA+ +  + P + VIGG +++ Q   KA +LY+T ID +
Sbjct: 66  VSRNASYPISGGEL--VGSLDEALKSLNEFPRVFVIGGEQLFRQAFDKADRLYITEIDLD 123

Query: 119 VE-GDTHFPDYEPDDWESV 136
           +E GDT F       W+ V
Sbjct: 124 IEGGDTFFEVPNASAWKEV 142


>UniRef50_A5EUV9 Dihydrofolate reductase n=1 Tax=Dichelobacter nodosus VCS1703A
           RepID=A5EUV9_DICNV
          Length = 164

 Score =  123 bits (309), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 66/160 (41%), Positives = 95/160 (59%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I LIAA  ++RVIG +  MPW+LP DL  FK+ T    +IMGR T++S+ +PLP RKNI+
Sbjct: 6   IHLIAAQTLNRVIGKDGGMPWHLPRDLQHFKQRTSGHTIIMGRKTFQSLKKPLPNRKNIV 65

Query: 62  L--SSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +  S QP   D V    ++ EA+A C +  ++ +IGGG +Y   + +A  L +T I  E+
Sbjct: 66  ISHSGQPLHAD-VAVFPAISEALAFCCNDEKVFIIGGGSLYAATIDEADFLTITWIHTEL 124

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GDT FP   P DW+        ADA+N+ +  F   +RR
Sbjct: 125 LGDTFFPPIRPQDWQETHRSHFAADAKNAFALDFVDYQRR 164


>UniRef50_B0MUX5 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM
           17216 RepID=B0MUX5_9BACT
          Length = 160

 Score =  123 bits (309), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 62/159 (38%), Positives = 97/159 (61%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI++I A+A + VIG +N + W++  DL  FK  T   PV+MGR T+ES+GRPLPGR+N+
Sbjct: 1   MIAIIVAVAENGVIGGDNRLLWHISEDLKHFKAVTTGHPVVMGRKTYESLGRPLPGRRNV 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +++ Q  + +    V S+DEA+A      ++ VIGG ++Y Q LP   + YLT +    +
Sbjct: 61  VVTRQNISIEGCDVVHSLDEALALFRPEEKVFVIGGAQIYAQALPLCDEFYLTRVFHAYQ 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FP ++  +WE + SE   +  +  + + FE   RR
Sbjct: 121 GDTCFPRWDEREWEIIDSESFASGKEFPYPFAFEHYRRR 159


>UniRef50_B6INW3 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria
           RepID=B6INW3_RHOCS
          Length = 190

 Score =  123 bits (308), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 69/166 (41%), Positives = 97/166 (58%), Gaps = 8/166 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           + L+AA+A + VIG  N +PW LP DL +FKR T+ KPV+MGR TWESIG +PLPGR NI
Sbjct: 24  LVLVAAVARNGVIGRGNTLPWRLPGDLRFFKRTTMGKPVVMGRRTWESIGAKPLPGRCNI 83

Query: 61  ILSSQPGTDDRVT-----WVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +L+   G           ++ ++ EA  +AA    PE+ VIGG  ++ + L  A +LYLT
Sbjct: 84  VLTRDTGFAPEGAIVCHGFLGAIAEARSVAARTGAPEVCVIGGESLFAEALRMADRLYLT 143

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + AE  GD  FP ++   W     E  DA   +S +Y    L+R+
Sbjct: 144 EVLAEPAGDVLFPPFDRGAWMQTELERADAAGPDSPAYRILRLDRK 189


>UniRef50_Q134B2 Dihydrofolate reductase n=10 Tax=Bradyrhizobiaceae
           RepID=Q134B2_RHOPS
          Length = 179

 Score =  122 bits (306), Expect = 4e-27,   Method: Compositional matrix adjust.
 Identities = 68/164 (41%), Positives = 93/164 (56%), Gaps = 7/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I +I A+A + VIG  NA+PW L +D   FK+ TLNKPVIMGR T++SIGRPLPGR NI+
Sbjct: 12  IVIIVAVAENGVIGEGNAIPWRLKSDQRRFKQLTLNKPVIMGRKTYQSIGRPLPGRTNIV 71

Query: 62  LSSQPGTDDRVTWVKSVDEAI--AACGD-----VPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++           V    EA    A GD       E++V+GG  +Y  +LP+A  + LT 
Sbjct: 72  VTRDTHFQAAGVVVAPSFEAAERVAAGDAMRRSATEVVVVGGSEIYAHWLPRATCIELTE 131

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + A  +GDT FP  +PD WE V    H A  ++S  + +    R
Sbjct: 132 VHASPQGDTTFPAIDPDQWEEVARTRHGAGPEDSVEFSYVTYRR 175


>UniRef50_P04174 Dihydrofolate reductase n=33 Tax=Neisseriaceae RepID=DYR_NEIGO
          Length = 162

 Score =  122 bits (305), Expect = 5e-27,   Method: Compositional matrix adjust.
 Identities = 61/134 (45%), Positives = 85/134 (63%), Gaps = 2/134 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           I++IAA A +  IG  NAMPW++P D A+FK  TL KPVIMGR TWES+  +PLPGR+NI
Sbjct: 4   ITIIAACAENLCIGAGNAMPWHIPEDFAFFKVYTLGKPVIMGRKTWESLPVKPLPGRRNI 63

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S Q          V S++ A+A C    E +++GG ++Y Q +P A  L +T +D  V
Sbjct: 64  VISRQADYCAAGAETVASLEVALALCAGAEEAVIMGGAQIYGQAMPLATDLRITEVDLSV 123

Query: 120 EGDTHFPDYEPDDW 133
           EGD  FP+ +   W
Sbjct: 124 EGDAFFPEIDRTHW 137


>UniRef50_C6X2F4 Dihydrofolate reductase n=20 Tax=Bacteroidetes RepID=C6X2F4_FLAB3
          Length = 167

 Score =  121 bits (303), Expect = 9e-27,   Method: Compositional matrix adjust.
 Identities = 61/161 (37%), Positives = 93/161 (57%), Gaps = 2/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI+++ A+ +   IG +N + W+LP DL  FK  T   P+IMGR T+ESIGRPLP R NI
Sbjct: 1   MITIVVAMGLKNEIGADNQLLWHLPQDLKHFKEITTGHPIIMGRKTYESIGRPLPNRTNI 60

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++S +     + V  V S+ EA+     + E + VIGGG +YEQ +  A KL +T + AE
Sbjct: 61  VVSRKKDWFAEGVLIVGSLKEALKFAKKIDENVFVIGGGNIYEQTIDLADKLEVTLVKAE 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +  D  FP  +   WE       D D ++++ +CF+   ++
Sbjct: 121 INADIFFPKIDLKIWEKTSETCIDKDEKHAYDFCFQTFVKK 161


>UniRef50_A7Z5T2 DfrA n=2 Tax=Bacillaceae RepID=A7Z5T2_BACA2
          Length = 161

 Score =  120 bits (302), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 62/164 (37%), Positives = 94/164 (57%), Gaps = 9/164 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS I A+  +R+IG +N +PW+LP DLA+FK+ T    ++MGR T+ESIGRPLP R+NI
Sbjct: 1   MISFIFAMDENRLIGKDNDLPWHLPDDLAYFKKVTTGHTIVMGRKTFESIGRPLPNRRNI 60

Query: 61  ILSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           +++S+     PG         S +E +       E  VIGG ++Y    P A +LY+T I
Sbjct: 61  VVTSRDESSFPG----CITADSAEEVLKLIPADEECFVIGGAQLYSALFPYADRLYMTKI 116

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
               EGD  FP++   +WE    +    D +N + Y + + E++
Sbjct: 117 HHVFEGDRFFPEFNEAEWELTSRKQGVKDEKNPYDYEYLVYEKK 160


>UniRef50_Q54277 Dihydrofolate reductase n=84 Tax=Bacilli RepID=DYR_STAHA
          Length = 166

 Score =  120 bits (302), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 62/158 (39%), Positives = 89/158 (56%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A+   RVIG +N +PW + +D  + K  T    +I+GR   +SIGR LP R+NII
Sbjct: 7   ISLIVAMDKKRVIGKDNDIPWRISSDWEYVKNTTKGHAIILGRKNLQSIGRALPDRRNII 66

Query: 62  LSSQPGTDDRVTWV-KSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+     + +   +  S++ A   C +  E+ + GG ++Y  FLP  +K+Y+T I  E E
Sbjct: 67  LTRDKNFNFKDCEIAHSIEAAFKLCENEEEVFIFGGEQIYVMFLPYVEKMYVTKIHHEFE 126

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT FP    DDW+ V  E    D +N + Y F I ER
Sbjct: 127 GDTFFPVVNFDDWKEVSVEKGIKDEKNPYDYYFHIYER 164


>UniRef50_Q7VQK5 Dihydrofolate reductase type I n=1 Tax=Candidatus Blochmannia
           floridanus RepID=Q7VQK5_BLOFL
          Length = 168

 Score =  120 bits (302), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 64/171 (37%), Positives = 95/171 (55%), Gaps = 18/171 (10%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           +ISLIAA  ++ VIG +N +PW    D+ WFK +T+ KPVIMGR T+ES+  +PLP R N
Sbjct: 2   IISLIAAFTINYVIGRKNIIPWYFSWDMMWFKYHTMYKPVIMGRKTFESMNSKPLPYRLN 61

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAACGDVP---------EIMVIGGGRVYEQFLPKAQKL 110
           I+LS        + +   +     AC  +          E+M+IGGG VY  F+ +  ++
Sbjct: 62  IVLSKH-----HILYNNKIHNIFIACNPIQALSVVQKNDEVMIIGGGLVYNAFMSQCTRM 116

Query: 111 YLTHIDAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSY--CFEILER 158
           YLT ID     GD+ FP Y P++W  V++          ++Y   F+IL+R
Sbjct: 117 YLTKIDVVYNYGDSWFPSYNPNEWCVVYNTNKKCVINTGYTYNLNFQILDR 167


>UniRef50_C6XMY9 Dihydrofolate reductase n=1 Tax=Hirschia baltica ATCC 49814
           RepID=C6XMY9_HIRBI
          Length = 182

 Score =  120 bits (301), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 66/166 (39%), Positives = 93/166 (56%), Gaps = 8/166 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           +++I A A + VIG++  +PW L  DL +FK  TL KPVIMGR TWES+  +PL GR N+
Sbjct: 15  LAMIVARAKNGVIGVDGDLPWRLKGDLKFFKSVTLGKPVIMGRKTWESLPFKPLKGRANL 74

Query: 61  ILSSQPGTDDRVTWV-------KSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           ++S +   D +   V        +   AIA   DV E+M+IGGG +Y         LY+T
Sbjct: 75  VVSRRHDFDAQGARVFPSLGVAIAAGRAIADQTDVEEVMIIGGGAIYTAAFENVDVLYVT 134

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            ++ E EGDT FP+ + D W  V    H AD  N H++    L R+
Sbjct: 135 EVNTEPEGDTFFPEIDDDVWTCVEETNHAADEDNDHAFVMRKLVRK 180


>UniRef50_A2SN57 Dihydrofolate reductase n=34 Tax=Burkholderiales RepID=A2SN57_METPP
          Length = 259

 Score =  120 bits (301), Expect = 2e-26,   Method: Compositional matrix adjust.
 Identities = 72/167 (43%), Positives = 96/167 (57%), Gaps = 13/167 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           +++IAA A + VIG  N +PW LP DLA F+  T   PVIMGR TWES+    RPLPGR+
Sbjct: 3   LAIIAACARNGVIGRNNDLPWRLPEDLAHFRSTTGGWPVIMGRLTWESLPARFRPLPGRR 62

Query: 59  NIILSSQ--PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           NII+S     G    V  V S++ A+          VIGG R+YE  LP A +L+LT ID
Sbjct: 63  NIIVSRGGVRGVPKGVDVVASLEAALELVQAERRAFVIGGARLYEAALPLADELFLTEID 122

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFH----DADAQNSHSYCFEILERR 159
            + EGD +FP+++     S F E H     A+A N+ +Y F    R+
Sbjct: 123 EDFEGDVYFPEFD----RSAFVEHHRMRRQAEAPNTFTYSFAHYRRK 165


>UniRef50_Q0SWS9 Dihydrofolate reductase n=1 Tax=Clostridium perfringens SM101
           RepID=Q0SWS9_CLOPS
          Length = 161

 Score =  119 bits (299), Expect = 3e-26,   Method: Compositional matrix adjust.
 Identities = 59/161 (36%), Positives = 96/161 (59%), Gaps = 5/161 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M S+I A +++ +IG+ N +PWN+P+DL  FK  T+ K ++MGR T+ES+   LPGR ++
Sbjct: 1   MFSIIVAKSINNIIGVNNKIPWNIPSDLKRFKELTMGKKILMGRKTFESLPFVLPGRTHL 60

Query: 61  ILSSQPG---TDDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +L+++         V     +D+ I+   D + EI VIGGG++Y +FL  A KLY+T + 
Sbjct: 61  VLTTKKDFSYNHKDVIIYNDLDKLISEYKDSMEEIFVIGGGKIYSEFLKYASKLYITEVL 120

Query: 117 AEVEGDTHFPDYEPDDWESVF-SEFHDADAQNSHSYCFEIL 156
            E +GDT+FP  +   W   + S  ++ +A       +EIL
Sbjct: 121 KEYKGDTYFPKVDYSKWIKTYESSIYEENATKFKYVIYEIL 161


>UniRef50_C5CTW3 Dihydrofolate reductase n=1 Tax=Variovorax paradoxus S110
           RepID=C5CTW3_VARPS
          Length = 177

 Score =  119 bits (298), Expect = 3e-26,   Method: Compositional matrix adjust.
 Identities = 64/163 (39%), Positives = 93/163 (57%), Gaps = 7/163 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           I LI A A + VIG +  +PW+LP D+  FK+ T   PV+MGR TW+S+    RPLPGR+
Sbjct: 10  IHLIFARAANGVIGAKGTIPWHLPEDMVHFKQQTAGAPVVMGRKTWDSLPPRFRPLPGRR 69

Query: 59  NIILSSQPGTDDRVTW-VKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           NI+++ Q        W V S+ EA+A C    VP++ +IGG ++Y +  P AQ++ +T +
Sbjct: 70  NIVVTRQDDWKAEGAWRVGSLQEALALCEESQVPDVWIIGGAQIYAEAEPLAQQVVVTEL 129

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             + EGD H P+  P  W     E H   A+   +Y F   ER
Sbjct: 130 AHDYEGDAHAPELSPSAWRETKREAH-VSAKEGLNYSFVTYER 171


>UniRef50_B9XJM4 Dihydrofolate reductase n=1 Tax=bacterium Ellin514
           RepID=B9XJM4_9BACT
          Length = 156

 Score =  118 bits (296), Expect = 6e-26,   Method: Compositional matrix adjust.
 Identities = 58/125 (46%), Positives = 78/125 (62%), Gaps = 1/125 (0%)

Query: 5   IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64
           IAA++ +RVIG  N +PW+LP D  WFK+ T  + V+MGR T+ESIGRPLP R+ I+LS 
Sbjct: 7   IAAMSQNRVIGQGNKIPWHLPEDFKWFKKMTTGQVVVMGRKTFESIGRPLPNRETIVLSR 66

Query: 65  QPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTH 124
            P     V  +  + E I+   +  EI + GG ++YEQ LP    LYLT +   VEGD  
Sbjct: 67  GPFQHPGVRTIFDLSE-ISLADESREIFICGGAQIYEQTLPMCSDLYLTVLKRTVEGDAF 125

Query: 125 FPDYE 129
           FP +E
Sbjct: 126 FPTFE 130


>UniRef50_Q5P234 Dihydrofolate reductase n=14 Tax=cellular organisms
           RepID=Q5P234_AZOSE
          Length = 167

 Score =  118 bits (295), Expect = 7e-26,   Method: Compositional matrix adjust.
 Identities = 68/165 (41%), Positives = 94/165 (56%), Gaps = 12/165 (7%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
            + +IAA A +  IG +N +PW L +DLA FK  T+  PV+MGR TWES+GRPLP R+N+
Sbjct: 7   QVIIIAATARNGAIGRDNQLPWRLKSDLARFKETTIGHPVLMGRKTWESLGRPLPARRNL 66

Query: 61  ILSSQPGTDDRVTWVKSV------DEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++     T DR             + A+ A GD   + VIGG  +Y Q L  A  L LT 
Sbjct: 67  VV-----TRDRSYSATGAEVFPDPEAALEAAGD-ETVFVIGGAELYRQLLDSADALLLTE 120

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + A+V GD +FP ++  D++ V  E HDADA N  S+ F    R+
Sbjct: 121 VHADVAGDAYFPPFDRGDFDEVRREQHDADAHNEFSFDFVEYRRK 165


>UniRef50_A0AJX9 DfrA protein n=15 Tax=Listeria RepID=A0AJX9_LISW6
          Length = 160

 Score =  118 bits (295), Expect = 7e-26,   Method: Compositional matrix adjust.
 Identities = 61/158 (38%), Positives = 91/158 (57%), Gaps = 3/158 (1%)

Query: 4   LIAALAVDRV--IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +I   A DR   IG +N MPW+LP DL +FK+ T  K ++MGR T+ES+G+ LP RK I+
Sbjct: 2   IIFVWAQDRAGNIGKDNTMPWHLPGDLQFFKKTTTGKTLVMGRKTYESLGKALPNRKTIV 61

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+       D    + S +E +A       I V+GG  +Y  F+  A KL +T IDAE +
Sbjct: 62  LTRDKELQLDDAEILHSREEVLALTQTGEPIYVVGGAEIYRLFMDVADKLIVTKIDAEFD 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            DT FP+ + +++  +  E H+ D +N ++Y F   ER
Sbjct: 122 ADTAFPEVDWENFSEIAKEPHEKDEKNKYNYTFYTYER 159


>UniRef50_C1XJD1 Dihydrofolate reductase n=1 Tax=Meiothermus ruber DSM 1279
           RepID=C1XJD1_MEIRU
          Length = 171

 Score =  118 bits (295), Expect = 7e-26,   Method: Compositional matrix adjust.
 Identities = 62/159 (38%), Positives = 94/159 (59%), Gaps = 5/159 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+ + A+  +R IG    +PW+LP DL  F+  TL K V+MGR T+ESIGRPLP R+N++
Sbjct: 5   IAFVVAMDQNRAIGRAGTLPWHLPDDLKRFRALTLGKTVLMGRKTFESIGRPLPKRRNVV 64

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119
           L+  P    + V  V ++++A+       E+MVIGGG +Y  FLP    L+LT ++  V 
Sbjct: 65  LTRDPAFAAEGVEVVHTLEDALKLDD---ELMVIGGGEIYTLFLPLVTHLHLTLVETVVP 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + D  FP + P  W   + E H AD ++  ++ +  LER
Sbjct: 122 DADAFFPPWNPTGWRETYREHHPADERHPWAFTYLDLER 160


>UniRef50_B2SDZ8 Dihydrofolate reductase n=19 Tax=Francisella RepID=B2SDZ8_FRATM
          Length = 180

 Score =  117 bits (294), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 61/162 (37%), Positives = 93/162 (57%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLI A   +  IG EN + W L  DL  FK+ T N  ++MGR T+ESIGRPLP RKNI
Sbjct: 15  MISLIVAYDKNFGIGKENTLAWKLSEDLKNFKKITENNYIVMGRKTFESIGRPLPNRKNI 74

Query: 61  ILS-SQPGTDDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           IL+  +    D+   + S  + +      P  EI +IGG ++Y++FL  A +LY+T +DA
Sbjct: 75  ILTRDKDYKQDKCLIINSTQDILNFAESKPHYEIFIIGGAQIYKEFLKYADRLYITEVDA 134

Query: 118 EV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E+ + D  FP ++   ++ +  +    D +N   + F + E+
Sbjct: 135 EMTDLDAFFPQWDKSKYKRIGHKQFKKDDKNEFDFTFSVFEK 176


>UniRef50_A0PY39 Dihydrofolate reductase n=3 Tax=Clostridium RepID=A0PY39_CLONN
          Length = 170

 Score =  117 bits (293), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 60/163 (36%), Positives = 92/163 (56%), Gaps = 5/163 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL--NKPVIMGRHTWESIGRPLPGRK 58
           M+S++ A+  + VIG ++++PW+LP DL +FK+ TL  +K +IMGR T++S+   LPGRK
Sbjct: 1   MLSIVVAIGKNNVIGKDHSLPWHLPNDLKYFKKVTLTESKTMIMGRKTFQSLKALLPGRK 60

Query: 59  NIILSSQPG---TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           +IIL+        D  V  +  +D       D  E  VIGGG ++   LP  +K+Y+T I
Sbjct: 61  HIILTKNKNFNMKDSNVEIINKIDMLKPIINDKKEYFVIGGGEIFSLLLPYTEKIYMTKI 120

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
                GDT FP+    DW +        D +N +++ F IL R
Sbjct: 121 HHNFIGDTFFPNINRYDWNTTKEIQGITDEKNVYNHTFLILNR 163


>UniRef50_A4BS77 Dihydrofolate reductase n=1 Tax=Nitrococcus mobilis Nb-231
           RepID=A4BS77_9GAMM
          Length = 162

 Score =  117 bits (293), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 63/155 (40%), Positives = 90/155 (58%), Gaps = 5/155 (3%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67
           +A +RVIG  + +PW LPAD+  F   T  KP++MGR   ++IGR LPGR NI+LS  P 
Sbjct: 1   MAENRVIGRAHGLPWRLPADMRHFVALTRGKPIVMGRRCHDTIGRALPGRHNIVLSRNPA 60

Query: 68  TDDRV---TWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTH 124
              RV     V  ++ A+A      EIM+IGG ++Y  FL +A ++YLT +   VEGD  
Sbjct: 61  --HRVPGCMLVHDLEAALAVAAGASEIMIIGGEQIYRLFLARADRIYLTLVHGRVEGDAF 118

Query: 125 FPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           FP  +  +W+    +   ADA N+++  F  L RR
Sbjct: 119 FPHLDAAEWQESARQSRLADADNAYALTFLTLLRR 153


>UniRef50_C8X9J8 Dihydrofolate reductase n=1 Tax=Nakamurella multipartita DSM 44233
           RepID=C8X9J8_NAKMY
          Length = 292

 Score =  117 bits (292), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 64/160 (40%), Positives = 91/160 (56%), Gaps = 10/160 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + L+AA+A + VIG    MPW++PADL  FKR T+  P++MGR T+ES+G  LPGR++I+
Sbjct: 8   VVLVAAVARNGVIGAAGTMPWHIPADLKRFKRLTMGHPMVMGRKTFESMGL-LPGRRSIV 66

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++  P           S+D AIA      P +MV+GGG +Y Q LP+A +L +TH+D   
Sbjct: 67  ITRDPHWRAPGAEVADSLDRAIALGAQTDPVVMVVGGGEIYAQALPRADRLEITHLDLSA 126

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GDT FP  +P  W          D + +  Y F    RR
Sbjct: 127 PGDTVFPAIDPALWAVT-------DREEADGYAFVTYRRR 159


>UniRef50_B9ECC1 Putative uncharacterized protein n=1 Tax=Macrococcus caseolyticus
           JCSC5402 RepID=B9ECC1_MACCJ
          Length = 164

 Score =  116 bits (290), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 57/140 (40%), Positives = 87/140 (62%), Gaps = 1/140 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAA++ + VIG +  +PW +P +   FK  T+ K VIMGR T+ESIG+PLP RK I
Sbjct: 2   IISLIAAISSNYVIGKDKDIPWKIPGEQVRFKDLTMGKSVIMGRKTFESIGQPLPNRKTI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I+S     + +    V+S++ A        EI + GGG +Y++ LP A ++YLT I+ E 
Sbjct: 62  IISKSKDINYNNCLTVESLERAFNLLQQEDEIFIAGGGEIYKESLPFADRIYLTIIEKEY 121

Query: 120 EGDTHFPDYEPDDWESVFSE 139
           EG+  FP +  D++E  + +
Sbjct: 122 EGNIFFPMFNKDEFEITYQQ 141


>UniRef50_C7RLL7 Dihydrofolate reductase n=1 Tax=Candidatus Accumulibacter
           phosphatis clade IIA str. UW-1 RepID=C7RLL7_9PROT
          Length = 169

 Score =  116 bits (290), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 64/169 (37%), Positives = 90/169 (53%), Gaps = 10/169 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           MISLIAA+A +  IG    + W LP D+ +F+  T  K VIMGR TWES+    RPLP R
Sbjct: 1   MISLIAAVARNGAIGRNQQLLWRLPEDMRYFRETTSGKTVIMGRKTWESLPPAYRPLPNR 60

Query: 58  KNIILSSQPGTDDRVT-WVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +NI+LS  P    R      S+++A+   G   E+ +IGG  +Y Q +P A +LY+T + 
Sbjct: 61  RNIVLSRNPAYLPRGGDLACSIEDALRLAGGAAEVFIIGGEELYRQTMPLATRLYITEVA 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSH------SYCFEILERR 159
            E  GD  FPD    +W  +      + A  S       ++ F + ERR
Sbjct: 121 EESPGDAFFPDVASGEWREISRRVGRSRAAGSALRDQAPAFDFVVYERR 169


>UniRef50_Q5V600 Dihydrofolate reductase 2 n=1 Tax=Haloarcula marismortui
           RepID=DYR2_HALMA
          Length = 167

 Score =  116 bits (290), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 70/150 (46%), Positives = 87/150 (58%), Gaps = 11/150 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR----PLPGR 57
           +SLIAA+A + VIG    +PW  P DL  FK  T+  PVIMGR T+ESI R    PLP R
Sbjct: 5   LSLIAAVAANGVIGAGGDIPWQYPEDLTHFKETTVGHPVIMGRRTFESIRRDLDGPLPER 64

Query: 58  KNIILSSQP-GTDDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
            NI+L++ P    D VT V S   A+  AA  D     VIGG  VYEQFLP+A +L LT 
Sbjct: 65  LNIVLTTTPHQLPDSVTAVTSTTAAVAEAADSDASTTYVIGGATVYEQFLPQADELILTE 124

Query: 115 IDAEVEGDTHFPDYEPDDW----ESVFSEF 140
           + A  +GDT FP  +  +W     +  SEF
Sbjct: 125 LAAAFDGDTVFPTVDWSNWTEMERTTHSEF 154


>UniRef50_Q0C500 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria
           RepID=Q0C500_HYPNA
          Length = 176

 Score =  115 bits (288), Expect = 4e-25,   Method: Compositional matrix adjust.
 Identities = 71/165 (43%), Positives = 91/165 (55%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60
           + LI A A +R+IG   A+PW L  D+A+FK  T+  PVIMGR TWES   RPLPGR+NI
Sbjct: 7   LCLIVAQARNRIIGAAGALPWRLKDDMAFFKATTMGAPVIMGRKTWESFPKRPLPGRENI 66

Query: 61  ILSSQPGTDDRVTWVKS-------VDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +L+     D     V S          AIAA     E  VIGG  +Y   LP A ++YLT
Sbjct: 67  VLTRDWDYDAAEARVYSSFPAAMNAARAIAAREGKDEAFVIGGAEIYALALPFADRIYLT 126

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            +DAE+EGDT FP+ +   W S     H A   N H++    L+R
Sbjct: 127 EVDAEIEGDTLFPELDLRQWRSDEIATHPAGEGNDHAFIIRRLDR 171


>UniRef50_Q9RR65 Dihydrofolate reductase n=2 Tax=Deinococcus RepID=Q9RR65_DEIRA
          Length = 180

 Score =  114 bits (286), Expect = 8e-25,   Method: Compositional matrix adjust.
 Identities = 64/160 (40%), Positives = 91/160 (56%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           I  IAA   +RVIG +  MPW+LPAD A F+  ++ KP IMGR  ++++ R PLP R NI
Sbjct: 17  IVAIAAQTENRVIGRDGGMPWHLPADFAHFRALSVGKPNIMGRKVFDTLRRKPLPERVNI 76

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L+       D      S +EA+   GD PEI +IGG  +Y  +  +  +L +T I AE+
Sbjct: 77  VLTRNENLKFDGCLIAHSPEEALQLAGDAPEIAIIGGEEIYRLYWDRLTRLEMTLIHAEL 136

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP+  P +WE     F  AD +N +   F+   RR
Sbjct: 137 DGDTFFPEIGP-EWELAQETFRPADEKNRYDLTFQTWRRR 175


>UniRef50_D2QWB5 Dihydrofolate reductase n=1 Tax=Pirellula staleyi DSM 6068
           RepID=D2QWB5_9PLAN
          Length = 171

 Score =  114 bits (285), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 59/159 (37%), Positives = 94/159 (59%), Gaps = 3/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLI A+  + +IG +  +PW + ADL  F+  T+   +IMGR TW+S+GR LPGR +I+
Sbjct: 11  LSLIVAMTREGLIGRDRDLPWKISADLKRFRSLTMGHTIIMGRTTWDSLGRALPGRTSIV 70

Query: 62  LSSQPG--TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           L+ +      + V    S+DEAIA      E  +IGGG +Y Q + + Q+LY+T ++A +
Sbjct: 71  LTRKADLVLPEGVLRAGSLDEAIALAAGDSEPFIIGGGEIYRQAMDRVQQLYVTWVEANI 130

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGDT FP ++P  +  +    H A+   + ++ F   ER
Sbjct: 131 EGDTWFPAWDPSKFRLLEETSHPAEG-TTPAFTFTRYER 168


>UniRef50_Q04F50 Dihydrofolate reductase n=2 Tax=Oenococcus oeni RepID=Q04F50_OENOB
          Length = 170

 Score =  114 bits (284), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 64/164 (39%), Positives = 92/164 (56%), Gaps = 5/164 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MI+ I A + + VIG  N +PW+LP DL +F++ T NK V+MGR T+ES G + LP R N
Sbjct: 1   MITSIWAQSKNNVIGRNNHLPWSLPDDLKFFRQETKNKAVVMGRKTYESFGSKALPKRLN 60

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAACGDVPE----IMVIGGGRVYEQFLPKAQKLYLTHI 115
           IIL+S          VK V   I A     E    + VIGG  VYE F+  A +L +T +
Sbjct: 61  IILTSNMDFKSNDPEVKIVHSPIEAVNTAKEQHLPLYVIGGASVYESFMNMADRLLITLV 120

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DA ++GDT  P++    +  V    H  D ++++S+ F   ER+
Sbjct: 121 DANIKGDTFAPNFSEKSFSLVSQCHHAQDKKHAYSFDFLTYERK 164


>UniRef50_UPI00016BFCBD Dihydrofolate reductase n=1 Tax=Epulopiscium sp. 'N.t. morphotype
           B' RepID=UPI00016BFCBD
          Length = 161

 Score =  113 bits (283), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 54/128 (42%), Positives = 87/128 (67%), Gaps = 6/128 (4%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +I A++ +  IG+ N +PWN+  D+ +F++ T  K VIMGR T+ SIGRPLP R+NI+L+
Sbjct: 1   MIVAVSKNGQIGIANELPWNIKEDMNYFRKMTTAKTVIMGRKTFNSIGRPLPNRRNIVLT 60

Query: 64  SQPGTDDRVTWVKSVD---EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +   TD ++  V+ V    EA+    +  +  VIGGG++YE F+P A++LY+T +D +++
Sbjct: 61  TN--TDLKIAGVEVVTNFAEALIIARE-EDAFVIGGGQIYELFMPYAEELYITEVDIDID 117

Query: 121 GDTHFPDY 128
           GD  FP+Y
Sbjct: 118 GDAAFPEY 125


>UniRef50_Q18HG9 Dihydrofolate reductase n=4 Tax=Halobacteriaceae RepID=Q18HG9_HALWD
          Length = 195

 Score =  113 bits (282), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 64/145 (44%), Positives = 83/145 (57%), Gaps = 11/145 (7%)

Query: 6   AALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNII 61
           AA+A + +IG +  MPW++PADL  FKR T+  PVI+GR T+E+I    G P PGR +I+
Sbjct: 37  AAVAANDIIGRDGEMPWHIPADLQQFKRRTMGHPVILGRRTYEAIIGALGEPFPGRTSIV 96

Query: 62  LSSQP-GTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           LSSQ       V  V S+  AI           V  + V GGG VYEQFLP A +L LT 
Sbjct: 97  LSSQSRDVPADVILVHSITSAIREASKNARERGVGTVYVAGGGGVYEQFLPLADRLRLTE 156

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSE 139
           +  E EGDT FP ++   W+    E
Sbjct: 157 LHDEYEGDTKFPSWDDTVWQETTRE 181


>UniRef50_B9LR90 Dihydrofolate reductase region n=2 Tax=Halobacteriaceae
           RepID=B9LR90_HALLT
          Length = 194

 Score =  113 bits (282), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 66/171 (38%), Positives = 98/171 (57%), Gaps = 14/171 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWES----IGRPLPGR 57
           + L+AA+A +RVIG +  MPW+ PADLA FKR T   PVI+GR T+ES    IG PLP R
Sbjct: 21  LVLVAAVAENRVIGDDGGMPWHYPADLARFKRLTTGHPVIVGRATYESIADRIGGPLPDR 80

Query: 58  KNIILSSQP-GTDDRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKL 110
            +++L+++     +       +DEA+   G       V ++ VIGG  VYEQFL +A ++
Sbjct: 81  TSVVLTTRDLDLPEGAVVANDLDEAVDLAGADAADRGVDDVYVIGGATVYEQFLDRADRM 140

Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQ---NSHSYCFEILER 158
            LT +  + +GDT FPD++ ++W     E   AD +    + +  F   ER
Sbjct: 141 VLTEVPEQPDGDTRFPDWDDEEWVETEREVVGADGERGGEADALAFVTYER 191


>UniRef50_C6W5S3 Dihydrofolate reductase n=1 Tax=Dyadobacter fermentans DSM 18053
           RepID=C6W5S3_DYAFD
          Length = 183

 Score =  112 bits (281), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 63/158 (39%), Positives = 90/158 (56%), Gaps = 5/158 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A A +  IG +N + W L  DL  FK+ TL  P+IMGR T+ESIG+PLPGR +I+
Sbjct: 20  ISIIVAAAENGAIGRDNQLLWRLSDDLKRFKQLTLGHPMIMGRKTFESIGKPLPGRTSIV 79

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D V  V S+DEA+    ++   E+ ++GGG +YEQ    A  +YLT +   
Sbjct: 80  ITRNANFAFDGVVVVHSLDEALEKAKEIDSQEVCIVGGGEIYEQSQAIATHIYLTKVHTS 139

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
           V GDT F   EP+ W       H+ D +  H + FE +
Sbjct: 140 VVGDTFFSIREPEAWTETERISHEPDER--HIFPFEFI 175


>UniRef50_C6P459 Dihydrofolate reductase n=1 Tax=Sideroxydans lithotrophicus ES-1
           RepID=C6P459_9PROT
          Length = 177

 Score =  112 bits (281), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 54/153 (35%), Positives = 82/153 (53%), Gaps = 1/153 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLI A+A +R IG+ N +PW  P DL  FK  T+   +IMGR T++SIG+PLPGR  ++
Sbjct: 19  LSLIVAMARNRTIGVNNTLPWRCPEDLKHFKTLTMGHHMIMGRKTFDSIGKPLPGRTTVV 78

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++     + +      S+ EA+  C    EI V+GG  +Y Q +     LY+T I  +V 
Sbjct: 79  ITRNNDLEIEGCIVAHSLQEALVTCAGDEEIFVVGGAELYRQAISLVDTLYVTEIQQDVA 138

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCF 153
           GD HFP+ +   W+    E    +      + F
Sbjct: 139 GDAHFPEIDKAFWQETSREMRSQETPQPMDFHF 171


>UniRef50_B2UP70 Dihydrofolate reductase n=1 Tax=Akkermansia muciniphila ATCC
           BAA-835 RepID=B2UP70_AKKM8
          Length = 159

 Score =  112 bits (281), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 61/142 (42%), Positives = 82/142 (57%), Gaps = 2/142 (1%)

Query: 5   IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64
           + A+A DR IG   A+PW+LP DL  FKR T   PV+MGR T+ESIGRPLPGR+NI+L+ 
Sbjct: 10  VVAMAPDRGIGYRGALPWHLPDDLKTFKRITTGHPVLMGRKTYESIGRPLPGRQNIVLTR 69

Query: 65  QPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDT 123
            P  T + V  V S  E        PEIMVIGG  ++   +P   +++++ +  E   DT
Sbjct: 70  DPAWTAEGVQVVHSAGELECLELMDPEIMVIGGAEIFSLMMPAMSRMWVSKVKGEYPADT 129

Query: 124 HFPDYEPDDWESVFSE-FHDAD 144
             P +E     +V  E F D D
Sbjct: 130 FLPPFENRLERAVLKEHFEDFD 151


>UniRef50_UPI0001C37DF3 dihydrofolate reductase n=1 Tax=Ruminococcus flavefaciens FD-1
           RepID=UPI0001C37DF3
          Length = 160

 Score =  112 bits (279), Expect = 5e-24,   Method: Compositional matrix adjust.
 Identities = 59/146 (40%), Positives = 88/146 (60%), Gaps = 3/146 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA A + VIG    +PW++P D+A+F+R T    VIMGR T+E IGRPLPGR N+
Sbjct: 1   MISIIAAAAKNGVIGAGGKIPWDIPEDMAYFRRITYGGAVIMGRRTYEDIGRPLPGRFNV 60

Query: 61  ILSSQPGTDDRVTWVK-SVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           ++S++  T    T +  S+ EA+   G+     I + GG  VY + L  A ++YLT +D 
Sbjct: 61  VVSAKMQTAPEGTALAHSLAEAVEIAGNSGRENIFLCGGAAVYREGLAFADRIYLTILDK 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDA 143
           E  GD +FP++   ++     E  D+
Sbjct: 121 EYSGDVYFPEFSEKEFRLTSYERCDS 146


>UniRef50_Q0TV23 Dihydrofolate reductase n=8 Tax=Clostridium perfringens
           RepID=Q0TV23_CLOP1
          Length = 161

 Score =  111 bits (278), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 54/159 (33%), Positives = 92/159 (57%), Gaps = 5/159 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M S+I A +++ +IG+ N MPWN+P+DL  FK  T+ K ++MGR T+ES+   LPGR ++
Sbjct: 1   MFSIIVAKSINNIIGVNNKMPWNIPSDLKRFKELTMGKKILMGRKTFESLPFVLPGRTHL 60

Query: 61  ILSSQPG---TDDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +L+++         V     +++ I+   D + EI VIGGG++Y + L    KLY+T + 
Sbjct: 61  VLTTKKDFSYNHKDVIIYNDLNKLISEYKDSMEEIFVIGGGKIYSELLKYTSKLYITEVL 120

Query: 117 AEVEGDTHFPDYEPDDWESVF-SEFHDADAQNSHSYCFE 154
            E +GDT+FP  +   W   + S  H+ +      + ++
Sbjct: 121 KEYKGDTYFPKVDYYKWIKTYESSIHEENGNKFKFFNYK 159


>UniRef50_C3RMT4 Dihydrofolate reductase n=4 Tax=Bacteria RepID=C3RMT4_9MOLU
          Length = 156

 Score =  111 bits (278), Expect = 7e-24,   Method: Compositional matrix adjust.
 Identities = 57/140 (40%), Positives = 88/140 (62%), Gaps = 4/140 (2%)

Query: 1   MISLIAALAVDRVIGME---NAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGR 57
           MI++I A   D +IG +   N MPWN+P DL  FK  TLNK ++MG  T+++IGRPLP R
Sbjct: 1   MINIIVATDEDLLIGKKDSRNGMPWNVPEDLQHFKATTLNKTILMGLTTYQAIGRPLPNR 60

Query: 58  KNIILSSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHID 116
           K I++S +P  D+RV    S++E I       E + + GG  +Y+Q LP A +L ++ I 
Sbjct: 61  KTIVVSFEPFEDERVEVRSSLEEVIEEYRSSGEDLFISGGASIYKQCLPIADQLLISRIP 120

Query: 117 AEVEGDTHFPDYEPDDWESV 136
            + EG+T+FP+++   ++ V
Sbjct: 121 GKHEGETYFPNFDEYGYKLV 140


>UniRef50_D0VXF2 Putative uncharacterized protein dfrP n=1 Tax=Bacillus phage
           phiNIT1 RepID=D0VXF2_9VIRU
          Length = 168

 Score =  111 bits (278), Expect = 8e-24,   Method: Compositional matrix adjust.
 Identities = 56/161 (34%), Positives = 91/161 (56%), Gaps = 5/161 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LIAA+ ++  IG +N + W++  D+ WF++ T NK V+MGR T+ESIG+PL GR N++
Sbjct: 3   VALIAAMGLNLEIGADNRLLWDIKEDMNWFRQKTKNKVVVMGRKTYESIGKPLKGRVNVV 62

Query: 62  LSSQPGTDDR--VTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           L+     D    V    ++++      +  EIMVIGG  +Y QF P A ++YLT ++   
Sbjct: 63  LTHNKEYDPHPDVLVRHNLEDIFFEFRNELEIMVIGGETIYNQFFPYANRIYLTQVEKTY 122

Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            E D  FP+++   W   F  + D        Y F + ++R
Sbjct: 123 EEADAFFPEFDCSIWNRYF--YQDGSEDIGIKYNFSVYKKR 161


>UniRef50_A5FJX2 Dihydrofolate reductase n=1 Tax=Flavobacterium johnsoniae UW101
           RepID=A5FJX2_FLAJ1
          Length = 160

 Score =  110 bits (276), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 59/160 (36%), Positives = 91/160 (56%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI +IAA+A +  +G  N + W+LP D   FK  T N  +IMGR T+ES  +PLP R +I
Sbjct: 1   MIIMIAAVAENNTLGKNNELVWHLPNDFKRFKSLTTNHHIIMGRKTFESFPKPLPNRTHI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++ Q   + +    V S+++AIAAC +  +  +IGGG +Y   LP A  + +T +    
Sbjct: 61  IITRQTDYNPEGCIVVDSMEKAIAACPENEDSYIIGGGEIYNLGLPYADIIEITKVHHTF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD  FP     +W+ V SE +  D ++ + Y +E   R+
Sbjct: 121 EGDAFFPKISKSEWQLVESEENFKDEKHLYDYTYETYIRK 160


>UniRef50_Q3BX85 Dihydrofolate reductase n=6 Tax=Xanthomonas RepID=Q3BX85_XANC5
          Length = 164

 Score =  110 bits (275), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 69/162 (42%), Positives = 96/162 (59%), Gaps = 4/162 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A   +  IG +N +PW LP DL  FK  TL KP++MGR T +S+GR LPGR N++
Sbjct: 3   LTLIVAFDRNNAIGRDNELPWKLPDDLKRFKALTLGKPILMGRKTAQSLGRALPGRLNLV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           L+       D +  V SV++AI  A      E+ VIGGG VY   + +A  L +T +D  
Sbjct: 63  LTRSGQVPFDGMQAVASVEQAIERAVQEGAQELCVIGGGEVYRLTMERADLLAVTEVDTA 122

Query: 119 VEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           V+G DTHFP  +P  W     E H ADA+++H++ F   ERR
Sbjct: 123 VDGADTHFPPIDPAVWSPARRELHAADARHAHAFSFVDYERR 164


>UniRef50_Q13PE2 Dihydrofolate reductase n=1 Tax=Burkholderia xenovorans LB400
           RepID=Q13PE2_BURXL
          Length = 171

 Score =  110 bits (275), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 57/128 (44%), Positives = 78/128 (60%), Gaps = 2/128 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + L+AA+A +RVIG+ N +PW +P +   F+  T+N+ V+MGR T+ESIG+PLPGR  ++
Sbjct: 7   VVLVAAMAANRVIGLGNDIPWRIPGEQKRFRELTMNQLVVMGRRTFESIGKPLPGRDLLV 66

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           LSS       V  VKS  E  AA  + P   I V GG +VY   +P A  +YLT ID   
Sbjct: 67  LSSGTSRLGTVRTVKSFAEVTAAVNNDPREAIFVGGGQQVYAMLMPYADVVYLTEIDLRP 126

Query: 120 EGDTHFPD 127
            GD  FP+
Sbjct: 127 PGDAFFPE 134


>UniRef50_B0VHY5 Dihydrofolate reductase n=1 Tax=Candidatus Cloacamonas
           acidaminovorans RepID=B0VHY5_9BACT
          Length = 141

 Score =  110 bits (274), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 57/141 (40%), Positives = 84/141 (59%), Gaps = 4/141 (2%)

Query: 20  MPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVK-SV 78
           MPW +  DL  FK  T+  PVIMG++TW SIG+PLPGR+NI+LS       +   V  S+
Sbjct: 1   MPWKITEDLKRFKAITMGHPVIMGKNTWNSIGKPLPGRQNIVLSKDRNFQPQGAIVAHSL 60

Query: 79  DEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFS 138
           +EA+    +  E  +IGG  V++QFLP A K+ +T I +E EGDT+FP +  +DW  +  
Sbjct: 61  EEALKMV-EGQEAYIIGGASVFKQFLPLADKMLITLIHSEFEGDTYFPYFSEEDW--ILQ 117

Query: 139 EFHDADAQNSHSYCFEILERR 159
           E     + + +  C +I  R+
Sbjct: 118 ESSSLLSSSGYELCLQIYIRK 138


>UniRef50_A2U3M8 Dihydrofolate reductase n=2 Tax=Polaribacter RepID=A2U3M8_9FLAO
          Length = 164

 Score =  110 bits (274), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 60/156 (38%), Positives = 90/156 (57%), Gaps = 3/156 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI++IAA+A +  +G  N + W+LPADL  FK+ T    ++MGR+T+ESIGRPLP R  I
Sbjct: 1   MITIIAAIAKNNALGKNNDLIWHLPADLKRFKKVTTGHHILMGRNTFESIGRPLPNRITI 60

Query: 61  ILS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPK--AQKLYLTHIDA 117
           I++ ++    +      SV++A+    D  +I +IGG +VYE  +    A  L +T +  
Sbjct: 61  IITKNEEYVQEGCLIANSVEQALEMAHDDDQIFIIGGAQVYEYAMKHDFADALDITLVHH 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCF 153
           E E D +FP+ +P  W  V  E   AD +N   Y F
Sbjct: 121 EFEADVYFPEIDPTVWRRVEREDFIADEKNKFDYSF 156


>UniRef50_A7IF75 Dihydrofolate reductase n=3 Tax=Rhizobiales RepID=A7IF75_XANP2
          Length = 178

 Score =  110 bits (274), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 57/144 (39%), Positives = 85/144 (59%), Gaps = 10/144 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++L+ A++ + VIG +  +PW LP+DL  F+  T  KP++MGR T+ESIGRPLPGR +++
Sbjct: 11  LALVVAVSQNGVIGTDGGLPWRLPSDLKRFRALTWGKPLLMGRRTYESIGRPLPGRTSVV 70

Query: 62  LSSQPGTDDRVTWVKS---------VDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112
           +S+ P        +K           DEA  A G   EIMVIGG R++   LP A+ L+L
Sbjct: 71  VSTDPAFTVPEGVLKGASLEDGLRLADEAADAMG-ADEIMVIGGARLFHDTLPLARTLHL 129

Query: 113 THIDAEVEGDTHFPDYEPDDWESV 136
           T + A  +GD  FP ++   W  +
Sbjct: 130 TQVHAAPDGDVFFPAFDEAQWREI 153


>UniRef50_Q11US6 Dihydrofolate reductase n=1 Tax=Cytophaga hutchinsonii ATCC 33406
           RepID=Q11US6_CYTH3
          Length = 161

 Score =  109 bits (273), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 66/162 (40%), Positives = 90/162 (55%), Gaps = 10/162 (6%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           S+I A + +R IG+ N +PW+LPADL  FK  T+   +IMGR T+ESIG PLPGR +I++
Sbjct: 4   SIIVAQSENRAIGINNTLPWHLPADLKRFKAITMGHHMIMGRKTYESIGNPLPGRTSIVV 63

Query: 63  SSQPGTDDRV----TWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +      D V    T   S+ EA  IA   +  E  VIGG  + ++ +    KLYLT I 
Sbjct: 64  TRNK---DLVFAGCTMAHSLAEAFEIAQNNNDSEAFVIGGAELIKEAINSCDKLYLTTIH 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              EGDT F D    DW+      H  D +N++SY F   E+
Sbjct: 121 QNFEGDT-FLDALASDWKETEHVVHAPDDKNAYSYSFITYEK 161


>UniRef50_Q47IJ5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=Q47IJ5_DECAR
          Length = 163

 Score =  109 bits (273), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 60/166 (36%), Positives = 93/166 (56%), Gaps = 14/166 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           I LIAA+A +RVIG +N + WNLP D+A FK  T  + V+MGR TWES+    RPLPGR+
Sbjct: 4   IILIAAVAKNRVIGKDNTLIWNLPEDMAHFKALTAGQTVVMGRKTWESLPPRFRPLPGRR 63

Query: 59  NIILSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           N+++S Q     PG +       S++ A+        + +IGG ++Y+Q +  A +L +T
Sbjct: 64  NVVISRQADYAAPGAE----VANSLENALQLASTAESVFIIGGEQIYKQAMAVADRLEIT 119

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +D E  GD  FP+    DW    ++ +   +Q+   + F    R+
Sbjct: 120 DVDLEPAGDAWFPEIAATDWS--VTQKNTPPSQSGTGFSFVTYRRK 163


>UniRef50_UPI00017452A7 Dihydrofolate reductase n=1 Tax=Verrucomicrobium spinosum DSM 4136
           RepID=UPI00017452A7
          Length = 167

 Score =  108 bits (271), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 56/131 (42%), Positives = 77/131 (58%), Gaps = 4/131 (3%)

Query: 5   IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNI 60
           IAA+A +RVIG +  +PW+LP DL +FK+ T   PV+MGR T+ESI    G+PLP R+NI
Sbjct: 14  IAAMASNRVIGRDGTLPWHLPEDLKFFKKTTAGHPVLMGRKTFESIVAALGKPLPNRRNI 73

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +LSS     + V  +  +            + +IGG ++YE  LP   +L LT ID   E
Sbjct: 74  VLSSTLAPQEGVEVIPHLASLSQLSALTSPVYLIGGAQLYEALLPVCDELLLTWIDQPYE 133

Query: 121 GDTHFPDYEPD 131
           GD  FP +E D
Sbjct: 134 GDAFFPAFEGD 144


>UniRef50_Q5HFZ7 Dihydrofolate reductase n=54 Tax=Staphylococcus aureus
           RepID=DYR_STAAC
          Length = 159

 Score =  108 bits (271), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 56/159 (35%), Positives = 92/159 (57%), Gaps = 4/159 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S++ A  + RVIG EN +PW+LP DL   K+ +    ++MGR T+ESIG+PLP R+N++
Sbjct: 3   LSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+S    + + V  + S+++     G V    + GG  ++E+ + K   +Y+T I+ +  
Sbjct: 63  LTSDTSFNVEGVDVIHSIEDIYQLPGHV---FIFGGQTLFEEMIDKVDDMYITVIEGKFR 119

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FP Y  +DWE   S     D +N+  + F  L R+
Sbjct: 120 GDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK 158


>UniRef50_Q5HPB1 Dihydrofolate reductase n=24 Tax=Bacilli RepID=DYR_STAEQ
          Length = 161

 Score =  108 bits (270), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 58/159 (36%), Positives = 90/159 (56%), Gaps = 4/159 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A    RVIG +N +PW+LP DL   K+ T    ++MGR T+ SIG+PLP R+N++
Sbjct: 3   LSIIVAHDKQRVIGYQNQLPWHLPNDLKHVKQLTTGNTLVMGRKTFNSIGKPLPNRRNVV 62

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L++Q     + V  + S+DE     G V    + GG  ++E  + +   +Y+T ID + +
Sbjct: 63  LTNQASFHHEGVDVINSLDEIKELSGHV---FIFGGQTLFEAMIDQVDDMYITVIDGKFQ 119

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FP Y  ++WE   S     D +N+  + F  L RR
Sbjct: 120 GDTFFPPYTFENWEVESSVEGQLDEKNTIPHTFLHLVRR 158


>UniRef50_C1IBP0 Dihydrofolate reductase n=1 Tax=Clostridium sp. 7_2_43FAA
           RepID=C1IBP0_9CLOT
          Length = 161

 Score =  108 bits (270), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 58/159 (36%), Positives = 89/159 (55%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59
           MISLI A+  +  IG +N +  ++  DL +FKR T    ++MG +T+ S+  RPLP R+N
Sbjct: 1   MISLIVAMDKNNGIGNKNKLLAHISEDLRYFKRVTDGNTIVMGYNTYMSLPKRPLPNRRN 60

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I+L+++    +    V S++E +       E  + GG  +Y Q LP A KLY+THI  E 
Sbjct: 61  IVLTTKDIKLEGAVVVNSIEELLKLLNTEEETFICGGSSIYNQMLPYADKLYITHIFDEF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E DT+FP+   D+WE   S  H  +  + H + F I  +
Sbjct: 121 EADTYFPEI-TDEWEISESFCHKENINHKHPHIFTIYTK 158


>UniRef50_Q0AN20 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria
           RepID=Q0AN20_MARMM
          Length = 173

 Score =  108 bits (269), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 61/165 (36%), Positives = 93/165 (56%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60
           + L+ A  ++ VIG++  +PW L +DL  FK  T  KP+IMGR TWES+  RPLPGR NI
Sbjct: 8   LVLVVARGMNGVIGVDGDLPWRLSSDLRNFKAITSGKPIIMGRKTWESLPRRPLPGRLNI 67

Query: 61  ILSSQPGTDDRVTWV-----KSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++ Q G       V     +++D A   A    V E+ VIGG ++Y   L +A +LYLT
Sbjct: 68  VVTRQDGYVAEGGHVAGDLGEAMDAAFMRADADGVDEVCVIGGAQIYAATLERADRLYLT 127

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            ++A  EG+T  P+ +   W     E + A   + H++   +L+R
Sbjct: 128 EVEAAPEGETCLPEIDEALWRETRRELYPAGPGDDHAFMLRVLDR 172


>UniRef50_A3HTR7 Dihydrofolate reductase n=1 Tax=Algoriphagus sp. PR1
           RepID=A3HTR7_9SPHI
          Length = 166

 Score =  107 bits (268), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 58/161 (36%), Positives = 92/161 (57%), Gaps = 4/161 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAA+A + VIG  N + W +P D   FK  T    ++MGR T+ES+G+PLP R +++
Sbjct: 3   ISLIAAVAKNGVIGKGNDLVWKIPTDFKRFKAITSGNYILMGRKTFESLGKPLPNRTHLV 62

Query: 62  LSSQPGTD--DRVTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +S        +     ++V++A   C    + ++ VIGGG +Y+Q +  A +L +T +DA
Sbjct: 63  ISRNKNYKVPEGHHLFENVEDAFIYCNKLGIEKLYVIGGGEIYKQTISIADELLITEVDA 122

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              GDT+FP+ + + W+ V  E   +D  N H + F   ER
Sbjct: 123 TPVGDTYFPEIDKNTWKIVSKESFPSDEINQHPFSFINYER 163


>UniRef50_C1SJK6 Dihydrofolate reductase n=1 Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SJK6_9BACT
          Length = 156

 Score =  107 bits (267), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 52/138 (37%), Positives = 79/138 (57%), Gaps = 1/138 (0%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           +LI A+  DRVIG  N MPW+LP DL  FK  T    + MGR T+ESIGRPLP R+N ++
Sbjct: 4   ALIVAMTKDRVIGKNNDMPWHLPEDLKLFKAKTTGHIIAMGRKTYESIGRPLPNRENFVI 63

Query: 63  SSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           +      D      SV E I A  +  + +  IGGG++Y   +    ++++++I    +G
Sbjct: 64  TRSGKEYDGCRVFGSVQECIKAAEEYDKTLFFIGGGQIYSDAVDMVDEMHISYIKENYDG 123

Query: 122 DTHFPDYEPDDWESVFSE 139
           DT FP+++   W+   +E
Sbjct: 124 DTFFPEFDESRWKVTETE 141


>UniRef50_B5EIA1 Dihydrofolate reductase region n=5 Tax=Geobacter RepID=B5EIA1_GEOBB
          Length = 306

 Score =  107 bits (266), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 62/158 (39%), Positives = 91/158 (57%), Gaps = 4/158 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS IAAL+ +RVIG +  +PW++P+DL  F+  T+   VIMGR T+ESIG PL GR+NI
Sbjct: 2   IISTIAALSDNRVIGADGGLPWDIPSDLTRFRSITMGHTVIMGRKTYESIGHPLLGRRNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +L+ +    +     ++V  AIAA     E+ + GGG V+++ LP  Q+LYLT +     
Sbjct: 62  VLTRKGSQIEGCEIARNVPAAIAAAEGEEEVFICGGGEVFQEALPLCQRLYLTVVHGNYR 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD   P+      E    EF D    +S    F +LE+
Sbjct: 122 GDAFLPELPEGFVELHREEFPDTTPPSS----FVVLEK 155


>UniRef50_C0XLT5 Dihydrofolate reductase n=3 Tax=Lactobacillus RepID=C0XLT5_LACHI
          Length = 162

 Score =  106 bits (265), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 58/160 (36%), Positives = 86/160 (53%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS I A   + +IG    +PW+LP D+A+FK+ T+  P+I G  T+ S  RPLPGR+NI
Sbjct: 1   MISYIWAEDENGLIGASGNLPWHLPDDMAFFKKTTMGHPIISGARTFRSYNRPLPGRQNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +LS      D V  + SV++        P+    V GG  ++ Q L K  +LY T I  +
Sbjct: 61  VLSRHGDFPDGVLVISSVEQLCELVDKNPKENYFVTGGANLFGQLLDKVDRLYRTKIHHQ 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             GDT+ P+ +   +  V S     D +N + + FE+ ER
Sbjct: 121 FTGDTYMPEIKYAQFNQVTSIDGIVDERNRYPHTFEVFER 160


>UniRef50_D0J8Z9 Dihydrofolate reductase n=2 Tax=Blattabacterium RepID=D0J8Z9_BLASP
          Length = 173

 Score =  106 bits (264), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 60/171 (35%), Positives = 92/171 (53%), Gaps = 14/171 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I LI+A++ + VIG  N + W+LP DL  FK  T  + V+MGR T+ESIG+ LPGR+NII
Sbjct: 3   IILISAVSSNGVIGKNNQLMWHLPNDLKRFKNMTFGETVLMGRKTFESIGKILPGRRNII 62

Query: 62  LS--------SQPGTDDRVTWVKSVDEAIAACGDV-----PEIMVIGGGRVYEQFLPKAQ 108
           L+        S   T+++ T  +   E  ++   +      +I VIGG ++Y   + KA 
Sbjct: 63  LTKKNKIHFFSSTNTNNK-TNPRGTFEVYSSLKQIYDLNYKKIFVIGGEKIYTSTIDKAH 121

Query: 109 KLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + LT I  +  GD  FP      W+  +  FH+ D  + ++Y F   ER+
Sbjct: 122 IIELTVIHKKFYGDAKFPKIPLSKWKKTYEFFHEKDKHHLYNYSFIRYERK 172


>UniRef50_A6GQA5 Dihydrofolate reductase n=1 Tax=Limnobacter sp. MED105
           RepID=A6GQA5_9BURK
          Length = 188

 Score =  106 bits (264), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 62/161 (38%), Positives = 92/161 (57%), Gaps = 26/161 (16%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S++AA+A + +IG+ N++PW+LP DLA+FK+ TL  PV+MGR T+ESI RPLPGR N++
Sbjct: 3   VSIVAAVAENGIIGINNSLPWHLPEDLAFFKQTTLGCPVLMGRKTYESINRPLPGRLNVV 62

Query: 62  LSSQ------PGTDDR----VTWVKSVDEA----IAACGDVP----------EIMVIGGG 97
           LSS       PG D      +T   ++ E     IA   ++P          ++ +IGG 
Sbjct: 63  LSSNSDWKPAPGKDGTPRSVITHPAALPEGSATQIATATNLPDALNWLSSFEQVFLIGGS 122

Query: 98  RVYEQFLPKA--QKLYLTHIDAEVEGDTHFPDYEPDDWESV 136
            +YEQ L +    +L LT I    EGD  FP ++   +  V
Sbjct: 123 NLYEQALAQGLVDELILTEIHQSFEGDASFPQWDRQQFREV 163


>UniRef50_B2TR57 Dihydrofolate reductase n=10 Tax=Clostridium RepID=B2TR57_CLOBB
          Length = 164

 Score =  106 bits (264), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 58/162 (35%), Positives = 91/162 (56%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M+S+I A+A + VIG +N + W++  DL  FK  T  K ++MGR T+ES+   LP RK+I
Sbjct: 1   MLSIIVAIAKNNVIGNDNKLIWHISEDLKRFKEITSGKTIVMGRKTFESLPGVLPNRKHI 60

Query: 61  ILSSQPG---TDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           IL+         + V  +   DE +    +   E+ +IGGG +Y+Q LP + KLYLT I+
Sbjct: 61  ILTRDKNFKVNSECVEIIYDFDELLNKYKNSDDEVFIIGGGEIYKQLLPYSNKLYLTKIN 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            + +GDT+FP    +D++  +      D ++   Y F  L R
Sbjct: 121 KDFDGDTYFPQINYNDFKIDYESDVITDEKSGLEYKFINLSR 162


>UniRef50_C5NYS7 Dihydrofolate reductase n=1 Tax=Gemella haemolysans ATCC 10379
           RepID=C5NYS7_9BACL
          Length = 163

 Score =  106 bits (264), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 51/160 (31%), Positives = 88/160 (55%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M+SLI A   ++ IG EN +PW L  D+   K  T N+ +IMGR T +SIGR LP R N 
Sbjct: 1   MLSLIVAYDKNKSIGQENTIPWRLKNDMLRVKELTTNQTIIMGRKTLDSIGRALPNRINR 60

Query: 61  ILSSQPGTDDRVTWVK-SVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L+    +    + ++   D++I    +  +  + GGG +Y ++  K  ++++T ++  V
Sbjct: 61  VLTRDKDSLSHYSNIEVYTDDSILDNIETEKAYIFGGGMIYNKYFDKCDEMFITEVNTIV 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E DT FP+++ ++WE +  E    D  N   + F   +R+
Sbjct: 121 EADTKFPEFDENEWELISREEFFKDENNEFDFVFIHFKRK 160


>UniRef50_B3ER85 Putative uncharacterized protein n=1 Tax=Candidatus Amoebophilus
           asiaticus 5a2 RepID=B3ER85_AMOA5
          Length = 164

 Score =  106 bits (264), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 65/160 (40%), Positives = 90/160 (56%), Gaps = 3/160 (1%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           S+I A AV+ VIG +  +PW++PADL  FK  T    VIMGR T+ES+   LP RK IIL
Sbjct: 4   SIIVAKAVNHVIGNKGRLPWHMPADLKHFKELTGGHHVIMGRKTFESLPGSLPDRKIIIL 63

Query: 63  SSQPGTD-DRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           S       +  T V S++ A  IA   +  E+ + GG  VY + L    K+YLT I  +V
Sbjct: 64  SQSLNYKVEDCTVVPSLEMALEIANQANETEVFIAGGAAVYREALGIVDKIYLTVIHTDV 123

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGDT FP  +   W  V    H+ D +++++Y F  L +R
Sbjct: 124 EGDTFFPTLKDHQWTEVSIVSHNHDIKHAYAYDFIELAKR 163


>UniRef50_C6XGC7 Dihydrofolate reductase protein n=1 Tax=Candidatus Liberibacter
           asiaticus str. psy62 RepID=C6XGC7_LIBAP
          Length = 176

 Score =  105 bits (263), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 54/139 (38%), Positives = 80/139 (57%), Gaps = 6/139 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I LIAA+  + VIG    MPW + +DL  FK  T   PV+MG  T++SIGR LPGR NII
Sbjct: 6   IILIAAITRNNVIGSCGGMPWKISSDLKRFKSLTTGNPVVMGYRTFQSIGRLLPGRTNII 65

Query: 62  L----SSQPGTDDRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           +    + +   +       S+ ++  +A+     +I +IGGG +Y Q +  A  LY+THI
Sbjct: 66  ITRDNTRRASVNPEAVLASSILDSLDLASKTGSKKIFIIGGGEIYAQTISLAHTLYITHI 125

Query: 116 DAEVEGDTHFPDYEPDDWE 134
           + E+EGD  FP  + + W+
Sbjct: 126 EKEIEGDVFFPSIDSNIWK 144


>UniRef50_D0J2N2 Dihydrofolate reductase region n=3 Tax=Bacteria RepID=D0J2N2_COMTE
          Length = 167

 Score =  105 bits (263), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 66/167 (39%), Positives = 92/167 (55%), Gaps = 12/167 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           I LI A A + VIG +N MPW+LP D+A FK  T    VIMGR TW+S+    RPLPGR 
Sbjct: 3   IQLIYARAANGVIGKDNTMPWHLPEDMAHFKELTRGCAVIMGRKTWDSLPPRFRPLPGRS 62

Query: 59  NIILSSQPG-----TDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYL 112
           NI+++ Q         D+V    S+ EA+    ++ + + VIGG ++Y Q LP A  + +
Sbjct: 63  NIVVTRQADWQAEPASDQVLRAASLSEALELGRNLSQDVWVIGGAQIYAQALPLADAVEV 122

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T I  + EGD   P+   + W++V    H   + N   YCF   ERR
Sbjct: 123 TEIGRDFEGDAFAPELG-EQWQAVSRSEH--VSANGLPYCFVRFERR 166


>UniRef50_A0Z2N0 Dihydrofolate reductase n=2 Tax=unclassified Gammaproteobacteria
           (miscellaneous) RepID=A0Z2N0_9GAMM
          Length = 184

 Score =  105 bits (263), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 60/161 (37%), Positives = 89/161 (55%), Gaps = 15/161 (9%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + L+ A++ + VIG  NA+PW+LP DL  FK+ T+  P++MGR T+ES+GRPLPGR N++
Sbjct: 13  VVLVLAVSENGVIGRGNALPWDLPDDLQHFKKATMGCPILMGRKTFESVGRPLPGRTNLV 72

Query: 62  LS-----SQPGTDDRVTWVKSVDE------AIAACGDVPEIMVIGGGRVYEQFLPKAQKL 110
           L+       PG    VT   SVD+      A A       + V+GG  +Y   LP+A ++
Sbjct: 73  LTRDSTWQAPG----VTIFSSVDKALALAEAQALIDGASAVCVVGGAEIYRLCLPRADRI 128

Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSY 151
            LT +  +V GD  F     + W+    E     A+NSH +
Sbjct: 129 LLTLVHGDVSGDATFDLSVLETWQEQRREHFPKGARNSHDF 169


>UniRef50_A1VQZ7 Dihydrofolate reductase n=9 Tax=Bacteria RepID=A1VQZ7_POLNA
          Length = 166

 Score =  105 bits (262), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 63/159 (39%), Positives = 88/159 (55%), Gaps = 9/159 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           I+LI A A + VIG  NAMPW+LP DLA FKR T   PVIMGR TW+S+    RPLPGR 
Sbjct: 6   INLIYARAANGVIGRNNAMPWHLPEDLAHFKRLTQGWPVIMGRKTWDSLPPRFRPLPGRT 65

Query: 59  NIILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           N++++ QP           S+ +A+A C    E+ VIGG ++Y    P A ++ +T I  
Sbjct: 66  NLVITRQPDWQAPGALPAASLADALAQCSQSEEVWVIGGAQIYAHAEPLADRIEVTEIAQ 125

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
           + +GD   P    ++W+    E H     +SH   F  +
Sbjct: 126 DFDGDAFAPPLG-EEWQETAREAH----VSSHGLPFSFV 159


>UniRef50_C2MBL2 Dihydrofolate reductase n=1 Tax=Porphyromonas uenonis 60-3
           RepID=C2MBL2_9PORP
          Length = 173

 Score =  105 bits (262), Expect = 5e-22,   Method: Compositional matrix adjust.
 Identities = 63/163 (38%), Positives = 89/163 (54%), Gaps = 6/163 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           I +I A A DR IG +  MPW L  DL   K  T    VIMGRHTW+SIG RPLP R NI
Sbjct: 3   IWIIVATARDRAIGRDGTMPWRLKDDLRRLKATTTGHAVIMGRHTWDSIGARPLPNRYNI 62

Query: 61  ILS-SQPGTDDRVTWVKS-VDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++S + P  D    +V S +++A+  C       + ++GGG +Y+  LP A  L LT +D
Sbjct: 63  VVSRTLPEGDAETHYVASTLEQALQHCQQAGYDRVYIMGGGVLYKSGLPYATHLNLTMVD 122

Query: 117 AEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             V + DTHFP+    +W  +    + AD +N +     + +R
Sbjct: 123 TVVPDADTHFPEINLSEWSKLEEAHYPADERNDYPVTQTLYKR 165


>UniRef50_Q3A0W8 Dihydrofolate reductase n=1 Tax=Pelobacter carbinolicus DSM 2380
           RepID=Q3A0W8_PELCD
          Length = 167

 Score =  105 bits (261), Expect = 5e-22,   Method: Compositional matrix adjust.
 Identities = 59/148 (39%), Positives = 84/148 (56%), Gaps = 11/148 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++++ A+  +R+IG    +PW++P DLA F+R T    ++MGR T+ESIGRPLPGR NI+
Sbjct: 16  MTIVVAMTAERIIGRRGQLPWSIPEDLALFRRLTYGHTLVMGRRTFESIGRPLPGRFNIV 75

Query: 62  LSSQ--PGTDDRVT--WVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +S    P    RV   + +++  A    GD   I  IGG  +Y Q L  A KL ++ I  
Sbjct: 76  VSRSMPPVEGLRVCRHFAEALQVADQGNGD---IFFIGGCEIYRQALIVAGKLSVSWIRK 132

Query: 118 EVEGDTHFPDYEPDDW----ESVFSEFH 141
              GD  FP+Y  DDW    E  +SEF 
Sbjct: 133 NYPGDCRFPEYRSDDWLIEQEQDYSEFR 160


>UniRef50_B2ICT5 Dihydrofolate reductase n=2 Tax=Beijerinckiaceae RepID=B2ICT5_BEII9
          Length = 198

 Score =  104 bits (259), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 60/169 (35%), Positives = 92/169 (54%), Gaps = 15/169 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++++AALA +RVIG+  AMPW+LP D   F+  T  KP++MGR T+ESIGR LPGR+ I+
Sbjct: 25  LTIVAALADNRVIGLNQAMPWDLPGDRRHFRERTWGKPMLMGRKTFESIGRALPGRETIV 84

Query: 62  LS-----SQPGTDDRVTWVKSVDEAIAACGDVPEIM------VIGGGRVYEQFLPKAQKL 110
           L+     + PG    V     ++ A+    D   IM      ++GGG ++   LP+ ++L
Sbjct: 85  LTRDETFAAPG----VLVAHDLEGALGLAHDWARIMGAKTIILVGGGELFAALLPRVERL 140

Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            LT ++   +GDT FP  +   WE            ++ SY F    R+
Sbjct: 141 ELTLVEGNPKGDTFFPPIDWSQWEEEKRSGPLQGPNDTISYQFVDYHRK 189


>UniRef50_C4FSY3 Putative uncharacterized protein n=1 Tax=Catonella morbi ATCC 51271
           RepID=C4FSY3_9FIRM
          Length = 169

 Score =  104 bits (259), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 59/162 (36%), Positives = 89/162 (54%), Gaps = 3/162 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           M++L+ A      IG +N +PW+LP DL +FK+ TL   ++MGR T+ES+G R LPGR +
Sbjct: 1   MLTLVYAQDQAGGIGYQNQLPWHLPNDLKFFKQVTLGHAILMGRKTFESMGCRLLPGRTS 60

Query: 60  IILSSQPGTDDRVTWVKSVD--EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
            +L+ Q      +  +  V   EAI A  +  E+MVIGG  ++   LP A ++  T I A
Sbjct: 61  YVLTRQEDYKSEIEGLHRVHNLEAIKALAEDQEVMVIGGAEIFAALLPLADRVIRTQIKA 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
               DT   D + D W+ V  +    D +N +++ FE   RR
Sbjct: 121 TFPADTFVADLDQDQWQCVEIQEGLVDDKNQYAHQFEWWVRR 162


>UniRef50_B4D395 Dihydrofolate reductase region n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4D395_9BACT
          Length = 201

 Score =  103 bits (257), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 56/164 (34%), Positives = 84/164 (51%), Gaps = 39/164 (23%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQP- 66
           ++++RVIG +N +PW+LP D  WFK+ T    V+MGR T+ES+GRPLP R NI+++ +P 
Sbjct: 1   MSLNRVIGRDNKIPWHLPEDFKWFKKLTTGHFVLMGRKTFESLGRPLPNRTNIVVTRKPL 60

Query: 67  ---------------------------------GTDDRVTWV----KSVDEAIAACGDVP 89
                                               +R  W+    + + +A        
Sbjct: 61  RLARDPQFKATVGQARVGHWQARFGRPYQLGFERLSERDVWLVRDPRKLADAFEKARPSR 120

Query: 90  EIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDW 133
           ++ VIGG ++YEQ LP+   LYL+ +  EVEGD  FP+ E DDW
Sbjct: 121 QLFVIGGAQIYEQLLPRCTDLYLSVVQREVEGDACFPELE-DDW 163


>UniRef50_C9RIZ1 Dihydrofolate reductase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RIZ1_FIBSS
          Length = 163

 Score =  103 bits (256), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 61/164 (37%), Positives = 92/164 (56%), Gaps = 8/164 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS I A++ + VIG +  +PW+L ADL  FK  T    +I+GR  ++ IGRPLP R N 
Sbjct: 2   LISAIVAVSENNVIGRDGHLPWHLSADLKRFKAITTGHAIILGRKNYDDIGRPLPNRTNY 61

Query: 61  ILSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           +L+       PG     +  +++ EA  A G+  E  +IGG  VY + +P  +KLYLT +
Sbjct: 62  VLTRNKDFQAPGCIVCSSLGEAI-EAARAAGET-ECFIIGGAAVYREAMPLVEKLYLTRV 119

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + VEGD  FP++  D ++   +E   AD +N     FEI  R+
Sbjct: 120 LSHVEGDVFFPEWN-DKFQKESAESFPADEKNDFPTTFEIWVRK 162


>UniRef50_B1MYC2 Dihydrofolate reductase n=3 Tax=Leuconostoc RepID=B1MYC2_LEUCK
          Length = 166

 Score =  103 bits (256), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 54/150 (36%), Positives = 82/150 (54%), Gaps = 4/150 (2%)

Query: 14  IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTD---D 70
           IG    + W+LP DL  FK  T+N  ++MGR TW++IGRPLPGR +++L+ Q       D
Sbjct: 16  IGKNGQLAWHLPDDLKLFKAETMNTLMVMGRTTWDTIGRPLPGRTSLVLTHQKDFKTPYD 75

Query: 71  RVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYE 129
            V    SVDE +     +  +I + GG  +Y  F+P A  L +T ID  + GDT     +
Sbjct: 76  DVIIAHSVDEVLDYIEKETRDISIAGGAAIYHAFMPYATDLIVTRIDVTIAGDTFVDAID 135

Query: 130 PDDWESVFSEFHDADAQNSHSYCFEILERR 159
              ++ V +  HD D ++ +S+  E  ER+
Sbjct: 136 LSQFKLVSATAHDKDDKHDYSFVVERYERQ 165


>UniRef50_C3JBM5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=C3JBM5_9PORP
          Length = 170

 Score =  102 bits (255), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 51/159 (32%), Positives = 88/159 (55%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60
           +S+I A+A +  IG +N + W+LP DL  FK  T    +IMG++T+ S+    LP R+NI
Sbjct: 3   LSIIVAVAANNAIGKDNDLLWHLPGDLKRFKETTTGHAIIMGKNTFHSLPNGALPNRRNI 62

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119
           ++SS     D V    ++  A+ A     E+ +IGG ++Y   LP A K+Y + ++    
Sbjct: 63  VVSSTLVPPDGVECYSTLQAALEAVAGEEEVFIIGGAQLYAASLPLADKIYFSRVEKGFP 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E DT+FP+++  +W   +   +  D +N ++    I +R
Sbjct: 123 EADTYFPEFDLTEWTPSYCTLYPEDERNEYAVTLTIYQR 161


>UniRef50_Q1GFV5 Dihydrofolate reductase n=18 Tax=Rhodobacterales RepID=Q1GFV5_SILST
          Length = 163

 Score =  102 bits (253), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 57/137 (41%), Positives = 84/137 (61%), Gaps = 6/137 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MI+LI A A +  IG +N +PW+ P DL  F+R TL   +IMGR+TW+S+  +PL  R N
Sbjct: 1   MITLIVARARNGAIGKDNDIPWHAPEDLKAFQRETLGGAIIMGRNTWDSLPFKPLKNRFN 60

Query: 60  IILSSQPGTDDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           I++SS P   D V  V S+DEAI  A       +  IGG  +Y+  L +A +L +T +D 
Sbjct: 61  IVVSSNPDAADTV--VASLDEAIDLARSEGYARLYGIGGAGIYKGMLARADRLMITEVDL 118

Query: 118 EV-EGDTHFPDYEPDDW 133
           E+ + D  FP++ P++W
Sbjct: 119 EIDDADAFFPEFPPEEW 135


>UniRef50_A8YUW1 Dihydrofolate reductase n=12 Tax=Lactobacillus RepID=A8YUW1_LACH4
          Length = 172

 Score =  101 bits (251), Expect = 9e-21,   Method: Compositional matrix adjust.
 Identities = 59/171 (34%), Positives = 91/171 (53%), Gaps = 16/171 (9%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI  + A      IG++  +PW LPAD+A FK  T+  P+IMGR T+ S+ R LP RK+I
Sbjct: 1   MIEFVWAEDQKHQIGLDGHLPWRLPADMAHFKEKTIGHPIIMGRKTFMSLPRLLPQRKHI 60

Query: 61  ILS------SQPGTDDRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQ 108
           +L+       +   +D+VT + S    IA  GD        ++  +GG  +++  L +  
Sbjct: 61  VLTHDQDLKKKYQDNDQVTIINS----IAELGDYIQNHQGEKLCTVGGVSIFKALLDQVD 116

Query: 109 KLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            L  T IDA  E DT  P+ + D ++ V  E H+AD +N + Y F   +R+
Sbjct: 117 VLEKTEIDATFEADTVMPEIDYDQFKLVKKEHHEADEKNKYPYTFFTYQRK 167


>UniRef50_D1BNV5 Dihydrofolate reductase region n=4 Tax=Veillonellaceae
           RepID=D1BNV5_VEIPT
          Length = 164

 Score =  100 bits (250), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 58/156 (37%), Positives = 87/156 (55%), Gaps = 4/156 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M++LI A+A +RVIG +N + W+LP DL +FK  T    +IMGR T+ES+   LP R++ 
Sbjct: 1   MLALIVAVAHNRVIGKDNTLIWHLPNDLKFFKEKTTGHVIIMGRKTFESLPFLLPNREHW 60

Query: 61  ILSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +++   G D  + V    + + A  A   +    VIGG +VYE FLP    +Y+T +D E
Sbjct: 61  VITRDKGFDAPEGVKIFHNPEAAAEAARALDAAYVIGGAQVYEAFLPYVDTMYITEVDHE 120

Query: 119 VEGDTHFPDYEPDDW--ESVFSEFHDADAQNSHSYC 152
            +GD  FP++  D +  ESV     D   Q  H + 
Sbjct: 121 FDGDAFFPEFSEDAFTIESVVDGIVDEKNQYPHRFV 156


>UniRef50_D1AYS8 Dihydrofolate reductase region n=1 Tax=Streptobacillus moniliformis
           DSM 12112 RepID=D1AYS8_STRM9
          Length = 156

 Score =  100 bits (250), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 51/161 (31%), Positives = 95/161 (59%), Gaps = 10/161 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI ++ A+  +  IG +N M W+   +L +F++ TLN  ++MG++T+ SIGRPL  R+NI
Sbjct: 1   MIHIVVAVGENNEIGKDNKMLWHNSEELRFFRKLTLNHKIVMGKNTYLSIGRPLDLRENI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIM-VIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S+    ++ +  ++++D+ +    D  EI+ VIGG  +Y+QFL   +K+YL+ ID + 
Sbjct: 61  VISTTLEENEDIYVLRNIDKILEKYVDSDEIIYVIGGENIYKQFLKYTEKIYLSKIDGKF 120

Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + D +FP    D++ +        +  N +++   I  RR
Sbjct: 121 PDADRYFPSINYDEYST--------EVVNYNTFKLYIYTRR 153


>UniRef50_Q6MID1 FolA protein n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MID1_BDEBA
          Length = 169

 Score =  100 bits (248), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 57/174 (32%), Positives = 95/174 (54%), Gaps = 21/174 (12%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59
           +++ + A + +RVIG +  +PW+LP D+ +F+  T    +IMGR T++S  GR LP R +
Sbjct: 2   ILTHVVACSQNRVIGAQGGLPWSLPEDMKFFRETTKGHIMIMGRKTFDSFNGRALPNRYH 61

Query: 60  IILSSQPGTDDR-------VTWVKSVDEAI-------AACGDVPEIMVIGGGRVYEQFLP 105
           I+++  P            V +V S++EA+       A  GD  E+ +IGGG +Y+Q +P
Sbjct: 62  IVVTRDPSKQSFNSTESSPVVFVASIEEAVKHAEPLTAKWGD--EVFIIGGGEIYKQAMP 119

Query: 106 KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
              K+YLT I  E  GDT++P+ +    E VF++    D +    + F    R+
Sbjct: 120 ITDKIYLTLIHREFPGDTYYPEID----EKVFTQTERRDIETPIPFSFLTYLRK 169


>UniRef50_A6L1Q7 Dihydrofolate reductase n=34 Tax=Bacteroidales RepID=A6L1Q7_BACV8
          Length = 164

 Score =  100 bits (248), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 56/155 (36%), Positives = 90/155 (58%), Gaps = 3/155 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           IS+I A+A +  IG EN + + LP DL  FK  T    +IMGR T+ES+ +  LP R+NI
Sbjct: 3   ISIIVAIARNHGIGFENKLLYWLPNDLKRFKALTTGHTIIMGRKTFESLPKGALPNRRNI 62

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI-DAE 118
           +LS + G          +++ A++ C +  EI +IGG  +Y++ +  AQ+LY+T I D  
Sbjct: 63  VLSRREGAVFAGAECFPALEIALSHCKEEEEIFIIGGASLYKEAMHIAQQLYITFIDDTS 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCF 153
            E D +FP+ + ++W+    E H  D ++ + Y F
Sbjct: 123 KEADAYFPEIKKEEWKETGREDHPTDEKHLYPYSF 157


>UniRef50_B8DW85 Dihydrofolate reductase n=6 Tax=Bifidobacterium RepID=B8DW85_BIFA0
          Length = 227

 Score =  100 bits (248), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 63/144 (43%), Positives = 83/144 (57%), Gaps = 18/144 (12%)

Query: 2   ISLIAALAVDR-----VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RP 53
           ++LI A A D+      IG E  MPW+LP DL  FK  T++ PVIMGR TWE++    RP
Sbjct: 37  VNLIWAQANDKEGRSGAIGYEGEMPWHLPEDLKRFKELTVSHPVIMGRKTWEALNEKFRP 96

Query: 54  LPGRKNIILSSQ-----PGTDDRVTWVKSVD----EAIAACG-DVPEIMVIGGGRVYEQF 103
           LP R NI+LS       PG        +++D    EAI   G D  EI VIGG +++ Q 
Sbjct: 97  LPNRDNIVLSRDRDFRAPGATVVDNLEEALDMARQEAIPDDGLDRSEIWVIGGSQLFNQM 156

Query: 104 LPKAQKLYLTHIDAEVEGDTHFPD 127
           LP A K+Y+T +DA+V  D + PD
Sbjct: 157 LPMASKIYMTQVDAKVNADAYAPD 180


>UniRef50_B8HHJ9 Dihydrofolate reductase n=2 Tax=Micrococcineae RepID=B8HHJ9_ARTCA
          Length = 181

 Score = 99.8 bits (247), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 64/169 (37%), Positives = 91/169 (53%), Gaps = 12/169 (7%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           +I +I A A + VIG +  MPW+LP D   F+R T    VIMGR TWES+    RPLPGR
Sbjct: 7   VIGMIWAQASNGVIGRDGTMPWHLPEDFEHFRRTTEGHSVIMGRRTWESLPEPFRPLPGR 66

Query: 58  KNIILSSQPG-TDDRVTWVKSVDEAIAACGDVP---EIMVIGGGRVYEQ--FLPKAQKLY 111
           +N++++S P  +        S+  A+AA    P   ++ +IGGG VY +  FL  A    
Sbjct: 67  RNLVITSDPAWSAPGAVRSSSILNALAAAAGQPGSDQVWIIGGGMVYREALFLRAANTAV 126

Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSE--FHDADAQNSHSYCFEILER 158
           +T I ++++GDT+ P+  P DWE   +E       A N   Y  E   R
Sbjct: 127 ITLIASDIDGDTYAPELGP-DWEMASAEPGVGWTTAANGTRYRIETWTR 174


>UniRef50_Q54801 Dihydrofolate reductase n=65 Tax=Streptococcus RepID=DYR_STRPN
          Length = 168

 Score = 99.8 bits (247), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 52/153 (33%), Positives = 92/153 (60%), Gaps = 8/153 (5%)

Query: 13  VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKNIILSSQPGTDDR 71
           VIG EN +PW+LPA+L  FK  TLN  ++MGR T++ +GR  LP R+ +IL+  P  +++
Sbjct: 16  VIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPKRETLILTRNP--EEK 73

Query: 72  VTWVKSVDEAIAAC----GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP- 126
           +  V +  +  +           + +IGG ++++ F P   ++ +THI A VEGDT+FP 
Sbjct: 74  IDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPE 133

Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + +   +E+V S+F+  D +N + +  +  +R+
Sbjct: 134 ELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRK 166


>UniRef50_C4L1C8 Dihydrofolate reductase region n=2 Tax=Exiguobacterium
           RepID=C4L1C8_EXISA
          Length = 162

 Score = 99.8 bits (247), Expect = 3e-20,   Method: Compositional matrix adjust.
 Identities = 55/159 (34%), Positives = 89/159 (55%), Gaps = 3/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS + A   +R IG +N + W LP DL  FK  T    V+MGR T+ESIG+ LP R+NI
Sbjct: 1   MISHVVAYGQNREIGKDNDLLWRLPDDLKHFKAITSGGTVVMGRKTFESIGKALPNRRNI 60

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++S    + D+V     +D  +A      E  VIGG  +YEQ +P   ++Y T + A  
Sbjct: 61  VVTSDVSFSADQVEVWHDLDR-LAEMSQQEEWFVIGGAMLYEQTMPMTSRIYATEVAASF 119

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E DT++P+ +  +W    +  H  D  +++++ F+  ++
Sbjct: 120 EADTYYPE-QTGEWSVTSTIDHPQDETHAYAFSFKQYDK 157


>UniRef50_Q03F97 Dihydrofolate reductase n=2 Tax=Pediococcus RepID=Q03F97_PEDPA
          Length = 161

 Score = 99.0 bits (245), Expect = 5e-20,   Method: Compositional matrix adjust.
 Identities = 56/157 (35%), Positives = 90/157 (57%), Gaps = 4/157 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+I A  +   IG + ++PW++P D+A+FK+ T    V+MGR T++SIG+ LP RKNI
Sbjct: 1   MISMIWAEDLRHGIGKQQSIPWHIPGDMAFFKKTTSGNTVVMGRKTFDSIGKALPNRKNI 60

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +LS  P +  D V  V S+ E  A     P  +  +IGG  +Y   L +A +L +T I  
Sbjct: 61  VLSHHPTSLPDSVVGVGSLSELQAIFETHPNEKFYIIGGSHLYNALLSQADELLITRIQK 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFE 154
           + + +   PD   ++++   S  H++  +N  +Y FE
Sbjct: 121 DYQCEVLAPDITQNEFKLASSVEHESTERNP-AYTFE 156


>UniRef50_A3K5B9 Dihydrofolate reductase n=1 Tax=Sagittula stellata E-37
           RepID=A3K5B9_9RHOB
          Length = 153

 Score = 98.6 bits (244), Expect = 5e-20,   Method: Compositional matrix adjust.
 Identities = 59/131 (45%), Positives = 78/131 (59%), Gaps = 6/131 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59
           MI+LIAA   +R IG +  +PW++P DLA FKR TL   ++MGR TWES+  +PL  R N
Sbjct: 1   MITLIAAHDRNRAIGKDGDIPWHIPEDLAMFKRETLGGAIVMGRKTWESLPFKPLKDRLN 60

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           I++S      + V  V SV++AIA         I  IGG R+YE  LP A +L +T +D 
Sbjct: 61  IVVSRDTSLHEHV--VGSVEDAIALAQSQGYFRIYGIGGQRIYEAMLPLAHRLLITEVDT 118

Query: 118 EV-EGDTHFPD 127
            V E D  FPD
Sbjct: 119 VVEEADAFFPD 129


>UniRef50_C7N8V9 Dihydrofolate reductase region n=5 Tax=Fusobacteriaceae
           RepID=C7N8V9_LEPBD
          Length = 173

 Score = 98.6 bits (244), Expect = 6e-20,   Method: Compositional matrix adjust.
 Identities = 53/163 (32%), Positives = 92/163 (56%), Gaps = 21/163 (12%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M SLI A+  +  IG  N + W++P DL  FK+ T+ K VIMG++T++SIG+PLP RKNI
Sbjct: 1   MFSLIVAVGENNEIGKNNQLLWHIPEDLKNFKKITMGKTVIMGKNTYKSIGKPLPNRKNI 60

Query: 61  ILSSQPG------TDDRVTWVKSVDEAIAACGDVP-----------EIMVIGGGRVYEQF 103
           +LS  P        +DR  + ++ +  +  C ++            EI +IGGG +Y++ 
Sbjct: 61  VLSRNPLEIEEKIKEDRKKY-ENENTKLELCDNLQKIIDKYKNSEEEIFIIGGGEIYKKA 119

Query: 104 --LPKAQKLYLTHID-AEVEGDTHFPDYEPDDWESVFSEFHDA 143
             +   +++Y++H++ ++   DT+FP  +   W  +  E +D 
Sbjct: 120 FEMKIVKRIYMSHVNFSDKNADTYFPKIDLKKWVVITKENYDG 162


>UniRef50_A1SJ32 Dihydrofolate reductase n=1 Tax=Nocardioides sp. JS614
           RepID=A1SJ32_NOCSJ
          Length = 160

 Score = 98.6 bits (244), Expect = 6e-20,   Method: Compositional matrix adjust.
 Identities = 55/144 (38%), Positives = 78/144 (54%), Gaps = 2/144 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + L+AA+A + VIG    +PW LP +   FK  T    ++MGR T++SIGRPLPGR  I+
Sbjct: 8   VVLVAAVARNGVIGDGPDIPWQLPGEQRLFKGLTWGHILVMGRATYDSIGRPLPGRTTIV 67

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           L+  P        V     A  A  D    E+MV GGG+VY   LP A +  L+ +D E 
Sbjct: 68  LTRSPDWSAEGVHVAHDLPAALALADTLEGEVMVAGGGQVYAAALPVADEQVLSEVDLEP 127

Query: 120 EGDTHFPDYEPDDWESVFSEFHDA 143
           +GD  +P+++  +W     E HD 
Sbjct: 128 QGDAFYPEFDRSEWRETAREQHDG 151


>UniRef50_Q59408 Dihydrofolate reductase type A13 n=57 Tax=Bacteria
           RepID=DYR13_ECOLX
          Length = 165

 Score = 98.6 bits (244), Expect = 6e-20,   Method: Compositional matrix adjust.
 Identities = 58/162 (35%), Positives = 84/162 (51%), Gaps = 10/162 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I L+AA+  +RVIG    +PW +P +   F+R T +K V+MGR T+ESIG+PLP R  ++
Sbjct: 8   IYLVAAMGANRVIGNGPDIPWKIPGEQKIFRRLTESKVVVMGRKTFESIGKPLPNRHTVV 67

Query: 62  LSSQPGTD----DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           LS Q G        V+ +  V  + A  G   E+ V  G  VY   LP A  ++L+ +  
Sbjct: 68  LSRQAGYSAPGCAVVSTLSHVSPSTAEHGK--ELYVARGAEVYALALPHANGVFLSEVHQ 125

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
             EGD  FP     ++E V SE      Q + +Y   +  RR
Sbjct: 126 TFEGDAFFPVLNAAEFEVVSSE----TIQGTITYTHSVYARR 163


>UniRef50_Q2S5H3 Dihydrofolate reductase n=3 Tax=cellular organisms
           RepID=Q2S5H3_SALRD
          Length = 186

 Score = 98.2 bits (243), Expect = 8e-20,   Method: Compositional matrix adjust.
 Identities = 63/138 (45%), Positives = 85/138 (61%), Gaps = 13/138 (9%)

Query: 2   ISLIAALAVD-RVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPG 56
           + +IAA+A D RVIG +  +PW++P DL  FK+ T   P++MGR T+ESI    G PLP 
Sbjct: 21  LVIIAAVAEDNRVIGQDKDLPWHIPEDLKRFKQLTTGHPLLMGRRTFESIVHQFGGPLPD 80

Query: 57  RKNIILSSQPGTDD-----RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLY 111
           RK ++L++Q   DD      V    SVD A+AA  D   + + GG  VYEQFLP A +L 
Sbjct: 81  RKMVVLTTQ---DDYEAYPEVDTYASVDAALAALPDDATVFIGGGESVYEQFLPHADRLE 137

Query: 112 LTHIDAEVEGDTHFPDYE 129
           LT ++   EGDT FP +E
Sbjct: 138 LTLVEGAYEGDTFFPPFE 155


>UniRef50_Q7UIC9 Dihydrofolate reductase n=1 Tax=Rhodopirellula baltica
           RepID=Q7UIC9_RHOBA
          Length = 195

 Score = 97.8 bits (242), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 61/163 (37%), Positives = 88/163 (53%), Gaps = 11/163 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+ + A   + VIG +  MPW L +DL  FK+ T+   +IMGR T+ESIGR LPGR+ I+
Sbjct: 31  ITAVVAATPNGVIGDDQDMPWRLSSDLKRFKKATMGGALIMGRKTFESIGRVLPGRQTIV 90

Query: 62  LSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           L+ Q     PGT           EAIA   D   I V+GGG++Y+Q+ P   +L+ T + 
Sbjct: 91  LTRQGHWQFPGTQT----ASGKSEAIALAADR-RIFVVGGGQIYQQWFPLCTELWWTRVW 145

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           A V GDT   D   D++E V        A++ +   +  + RR
Sbjct: 146 ANVSGDTRV-DLPLDEFELVSQTSFPVTAKDDYPTDWLRMRRR 187


>UniRef50_A1TM51 Dihydrofolate reductase n=4 Tax=cellular organisms
           RepID=A1TM51_ACIAC
          Length = 165

 Score = 97.4 bits (241), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 60/165 (36%), Positives = 88/165 (53%), Gaps = 9/165 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           + LI A A +  IG+ NAMPW+LP DLA FK+ TL   V+MGR TW+S+    RPLPGR 
Sbjct: 3   LRLIYARAANGGIGLHNAMPWHLPEDLAHFKQLTLGATVVMGRKTWDSLPARFRPLPGRT 62

Query: 59  NIILSSQPG-TDDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           NI+++ Q G   D      S+++A+      GD   + V+GG ++Y Q LP A  + +T 
Sbjct: 63  NIVVTRQAGWHADGALSASSLEQAVELARPHGDT--VWVMGGAQIYAQALPMADGVEVTE 120

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           I  + E D   P   P+  E+  +    +    +  + F    RR
Sbjct: 121 IHRDFEADAFAPVLGPEWEETARTPVQTSAGSAALPFSFVSYRRR 165


>UniRef50_A1WYQ0 Dihydrofolate reductase n=1 Tax=Halorhodospira halophila SL1
           RepID=A1WYQ0_HALHL
          Length = 164

 Score = 97.4 bits (241), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 62/161 (38%), Positives = 81/161 (50%), Gaps = 8/161 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I L+A +  + VIG +   PW+   DL  FK  T   PVIMGR T  +IGRPLP R NI+
Sbjct: 4   IVLVAIVGRNGVIGADGDQPWHFRCDLQRFKALTRGHPVIMGRRTLAAIGRPLPQRTNIV 63

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVP----EIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           L+  PG       V +  EA  A          +M++GGG VY  FLP+A +L LT +D 
Sbjct: 64  LTRDPGFHADGVEVATDPEAALARAAESAGGERVMILGGGDVYRLFLPRAHRLALTEVDD 123

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              GDT FP   P +W+    E  + D    +   F  L R
Sbjct: 124 APPGDTTFPAIGP-EWQETAREEAEEDG---YRLTFRTLLR 160


>UniRef50_UPI00016B2267 dihydrofolate reductase n=1 Tax=candidate division TM7 single-cell
           isolate TM7c RepID=UPI00016B2267
          Length = 178

 Score = 97.1 bits (240), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 65/162 (40%), Positives = 88/162 (54%), Gaps = 8/162 (4%)

Query: 3   SLIAALAVDRVIGMENAMPW--NLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           ++I A   +R IG    +PW  +LPADLA FK+ T    +IMG  T+ESIG RPL  RKN
Sbjct: 17  AIIVAYDRNRAIGRGGDLPWGRSLPADLAHFKQLTKGGGIIMGHRTFESIGSRPLLERKN 76

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL--PKAQKLYLTHIDA 117
           I++SS+P   + V  V  +  A+A         +IGG RVY   L  P+   +Y T IDA
Sbjct: 77  IVISSRPTDSEGVLTVMDLPSALALSH--YSTFIIGGARVYADALETPEIDTIYATEIDA 134

Query: 118 EVEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              G DT FP+ +   W+      H ADA N + + F I +R
Sbjct: 135 SFPGADTFFPEIDMSIWQETSRIRHPADADNVYDFDFVIYKR 176


>UniRef50_C4Z3U6 Dihydrofolate reductase n=8 Tax=Firmicutes RepID=C4Z3U6_EUBE2
          Length = 157

 Score = 96.7 bits (239), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 50/152 (32%), Positives = 86/152 (56%), Gaps = 3/152 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI LI A + + VIG    +PW +  +  +FK  T+   V+MGR ++E IG PLP R+NI
Sbjct: 1   MIGLIVARSKNNVIGRNGEIPWKIKGEQKFFKELTIGNIVVMGRKSYEEIGHPLPNRQNI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I+S     + + +  V S+ EA+ A  D   I + GG  VY++ +P    +Y+T +D  +
Sbjct: 61  IVSKTMKYEGENLITVSSLAEAL-ALSDNSNIYIAGGYGVYKEAIPFVDVMYITEVDMNI 119

Query: 120 E-GDTHFPDYEPDDWESVFSEFHDADAQNSHS 150
           E GD  FP+++ +D++ +  E    + + + +
Sbjct: 120 EDGDVFFPEFDVNDFDLIIGETFGENTKYTRT 151


>UniRef50_C0QWN0 Dihydrofolate reductase n=2 Tax=Brachyspira RepID=C0QWN0_BRAHW
          Length = 166

 Score = 96.7 bits (239), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 53/144 (36%), Positives = 86/144 (59%), Gaps = 9/144 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPW-NLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRK 58
           ++SLIAA+     IG+   MPW ++  D+ +F+  T    VIMGR T+ES+G +PLP RK
Sbjct: 2   IVSLIAAVDSKNGIGLNGVMPWGHIKEDMQFFRSTTTGYAVIMGRVTFESLGSKPLPNRK 61

Query: 59  NIILSSQPGTD-----DRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLY 111
           NI++SS   T+     D + + KS +++I+        +I +IGG  +Y++ L  A  +Y
Sbjct: 62  NIVISSNVNTELLNKYDNLFYEKSFEDSISKLLLEKNKQIFIIGGESIYKKALDYADMIY 121

Query: 112 LTHIDAEVEGDTHFPDYEPDDWES 135
           LTHID +   D  FP+ + + ++S
Sbjct: 122 LTHIDKDYHCDRFFPEIDTNLFQS 145


>UniRef50_A6WGF8 Dihydrofolate reductase n=5 Tax=Actinomycetales RepID=A6WGF8_KINRD
          Length = 171

 Score = 96.3 bits (238), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 61/140 (43%), Positives = 77/140 (55%), Gaps = 8/140 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           MI L+ A + + VIG    +PW +P DLA F   T    V+MGR TWES+    RPLPGR
Sbjct: 1   MIGLVWAQSRNGVIGAGGRIPWRVPEDLAHFSALTAGSTVVMGRATWESLPARFRPLPGR 60

Query: 58  KNIILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +N++LS  PG   +    V  +  A+A  GDV    VIGG  VY   L  A  L +T +D
Sbjct: 61  RNLVLSRDPGYAAEGAEVVHDLPGALAGAGDV---WVIGGSAVYRAALEHADVLVVTEVD 117

Query: 117 AEVEGDTHFPDYEPDDWESV 136
             VEGDT  P+  P  WE V
Sbjct: 118 LVVEGDTRAPEVGP-GWERV 136


>UniRef50_B7C7C2 Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM
           3989 RepID=B7C7C2_9FIRM
          Length = 159

 Score = 95.9 bits (237), Expect = 4e-19,   Method: Compositional matrix adjust.
 Identities = 47/130 (36%), Positives = 80/130 (61%), Gaps = 2/130 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LIAA+  +R +G  N M W+LP DL +F++ T    ++MGR T+ES+   LP R +++
Sbjct: 3   LTLIAAIGKNRELGKNNDMIWHLPQDLKFFRQETSGHTIVMGRKTFESLPGKLPKRHHVV 62

Query: 62  LS-SQPGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +S +     + +   +SV+E +    DV  EI  IGGG +Y + L  A +L LT IDA+ 
Sbjct: 63  ISRTCKDLGEDIEMCESVEEFMKRYKDVDEEIYCIGGGMIYSEMLKYASRLVLTQIDADA 122

Query: 120 EGDTHFPDYE 129
           + + +FP+++
Sbjct: 123 DAEVYFPEFD 132


>UniRef50_UPI0001874368 dihydrofolate reductase n=1 Tax=Corynebacterium amycolatum SK46
           RepID=UPI0001874368
          Length = 176

 Score = 95.5 bits (236), Expect = 5e-19,   Method: Compositional matrix adjust.
 Identities = 60/145 (41%), Positives = 78/145 (53%), Gaps = 15/145 (10%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
            + +I A +   +IG    MPW+LP DL  FK  T+  PVIMGR TW+S+    RPLPGR
Sbjct: 14  FVGMIWAQSRAGIIGDGATMPWHLPEDLQHFKTTTMGAPVIMGRRTWDSLNPKFRPLPGR 73

Query: 58  KNIILSSQ----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +NI+LS      PG +       S++ A+AA  D P   +IGGGRVY   L  A +  +T
Sbjct: 74  RNIVLSRSVSDFPGAES----ATSLEAALAAVADEPAAWIIGGGRVYRDALSLADECVVT 129

Query: 114 HIDAEVEGDTHFPDYEPD--DWESV 136
            ID +V      P   PD  DW  V
Sbjct: 130 DIDTDVS--VPVPVMAPDLYDWVRV 152


>UniRef50_A5VJL0 Dihydrofolate reductase n=8 Tax=Lactobacillus RepID=A5VJL0_LACRD
          Length = 162

 Score = 95.5 bits (236), Expect = 5e-19,   Method: Compositional matrix adjust.
 Identities = 56/147 (38%), Positives = 83/147 (56%), Gaps = 2/147 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           ++LI A  ++  IG +N +PW++ AD+  FK  T   P+IMGR T+ S+G +PLP R+NI
Sbjct: 4   LNLIWAEDLNGWIGKDNTIPWHVSADMKHFKTKTTGHPIIMGRRTFASLGNKPLPKRENI 63

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L+S+    + V  V S+          P E  VIGG  +Y+Q LP A KL  T I+ ++
Sbjct: 64  VLTSRNIDAEGVEVVHSLAALKEYLKANPNEYFVIGGATIYQQLLPMATKLTRTVINKQI 123

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQ 146
            GDT  P  + D W  V    ++ D Q
Sbjct: 124 VGDTKMPTIDYDRWHLVNHNNYEKDDQ 150


>UniRef50_Q1WU16 Dihydrofolate reductase n=5 Tax=Lactobacillus RepID=Q1WU16_LACS1
          Length = 167

 Score = 95.1 bits (235), Expect = 6e-19,   Method: Compositional matrix adjust.
 Identities = 56/167 (33%), Positives = 87/167 (52%), Gaps = 8/167 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS + A      IG +  +PW LPADLA FK  T+  P++MG+ T++S    LP R++I
Sbjct: 1   MISFVWAEDQKHQIGYKGHLPWRLPADLAHFKEVTMGHPMVMGKKTFDSFPGLLPRRQHI 60

Query: 61  ILSSQPGTDDR------VTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYL 112
           +L+     +++      V  + S+DE  +   +    E+ VIGG  ++   L K  KLY 
Sbjct: 61  VLTHDTNLEEKYKDNPQVEIMNSIDELTSWLDENQFQEVSVIGGAMLFNLLLNKVDKLYK 120

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T I +E  GDT  P    D+++ V  +    D +N + Y F   ER+
Sbjct: 121 TEILSEFNGDTVMPTINYDEFKLVSKKIGKVDEKNKYPYVFLEYERK 167


>UniRef50_Q38WX9 Dihydrofolate reductase n=5 Tax=Lactobacillales RepID=Q38WX9_LACSS
          Length = 166

 Score = 95.1 bits (235), Expect = 6e-19,   Method: Compositional matrix adjust.
 Identities = 54/167 (32%), Positives = 93/167 (55%), Gaps = 13/167 (7%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59
           MI+ + A   + +IG +  +PW LP DLA FKR T+N+ VIMGR T++S+  +PLPGR+N
Sbjct: 1   MIAFLWAEDQNGLIGQDGHLPWRLPNDLANFKRETINEAVIMGRKTYDSLPKKPLPGRQN 60

Query: 60  IILSSQPGTDDRVTWVKSV------DEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLY 111
           I+++ Q G    +T  K V       + +    + P  ++ +IGG  +++ F      LY
Sbjct: 61  IVITRQSG----LTVAKDVLVFNERTQLLDYQKEHPMQKLFIIGGADIFKLFAADVDYLY 116

Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +T I  + +GD + P  +   ++ +  +    D +N + + FEI +R
Sbjct: 117 VTKIAEKFKGDVYMPTIDYTQFKLISQKAGAVDERNQYPHTFEIYQR 163


>UniRef50_C9BJS9 Dihydrofolate reductase n=13 Tax=Enterococcus RepID=C9BJS9_ENTFC
          Length = 175

 Score = 95.1 bits (235), Expect = 7e-19,   Method: Compositional matrix adjust.
 Identities = 56/161 (34%), Positives = 89/161 (55%), Gaps = 3/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           M++ I A   + +IG E+ +PW LP DL +FK+ T    ++MGR T+E +G RPLP R+ 
Sbjct: 1   MLAAIWAQDENGLIGKEDRLPWRLPNDLKFFKQMTEANTLVMGRKTFEGMGSRPLPNRQT 60

Query: 60  IILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGR-VYEQFLPKAQKLYLTHIDA 117
           I+L+       + V  + SV++ +A   +   I  I GG  VY++FLP    LY T I  
Sbjct: 61  IVLTRDSSYKAEGVHVMHSVEDVLALEKETDGIFFIAGGSAVYQEFLPFCTILYRTVIHH 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             +GD +FP  +  DW  + +   + D +N + + FE  +R
Sbjct: 121 VFDGDAYFPPVDWSDWSLINTSQGEMDEKNRYPHQFETYQR 161


>UniRef50_Q044A0 Dihydrofolate reductase n=13 Tax=Lactobacillus RepID=Q044A0_LACGA
          Length = 171

 Score = 94.4 bits (233), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 60/167 (35%), Positives = 86/167 (51%), Gaps = 8/167 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI  I A   D  IG +  +PW+LPADL  FK  T N  ++MGR T+ES    LP R++I
Sbjct: 3   MIRFIWAEDEDGHIGYQGTLPWHLPADLKHFKDLTSNHIIVMGRRTFESFPGLLPKRQHI 62

Query: 61  ILSSQPGTDDR------VTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYL 112
           ILS+ P    +      V     + E      D  E  I +IGG RV+E+F+ +   +  
Sbjct: 63  ILSTSPTLQRKYQNNAHVKIFSQLKELKNWIKDHSEQTIDIIGGARVFEEFMDEVDMIEK 122

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T I    +GDT  P    +D+E + ++ H AD +N  +Y F   ER+
Sbjct: 123 TKIHHVFKGDTLMPKINYEDFELINTKAHQADEKNKFAYDFLEYERK 169


>UniRef50_B9YFM0 Dihydrofolate reductase region n=3 Tax=Nostocaceae
           RepID=B9YFM0_ANAAZ
          Length = 166

 Score = 94.4 bits (233), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 56/175 (32%), Positives = 92/175 (52%), Gaps = 29/175 (16%)

Query: 1   MISLIAALAVDRVIG------MENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPL 54
           +ISLIAA++ +R++       +   +PW++P+DL  F++ T   PVI+GR ++ +   PL
Sbjct: 3   LISLIAAISENRILADSKKEHIRVGIPWDIPSDLQHFQKKTWRHPVILGRKSYAAFNHPL 62

Query: 55  PGRKNIILSSQ-----PGT------DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQF 103
           P R NIIL+       PG        + VTW K          +  EI + GGG ++ + 
Sbjct: 63  PNRTNIILTRSHDYKAPGCLVFYSLSEAVTWAK--------MSEKEEIFIAGGGEIFAEA 114

Query: 104 LPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +  A KLYLT ++   EGD +FP++   ++ +V  E H    +N   + F  +ER
Sbjct: 115 IKFANKLYLTIVEGNFEGDVYFPEF--TNFGTVTKEEH--SQENDFQFKFVEIER 165


>UniRef50_A1WMP6 Dihydrofolate reductase n=2 Tax=Proteobacteria RepID=A1WMP6_VEREI
          Length = 162

 Score = 94.0 bits (232), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 52/129 (40%), Positives = 76/129 (58%), Gaps = 4/129 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           + LI A A + VIG +  +PW+LP D+A F++ T    VIMGR TW+S+    RPLPGR 
Sbjct: 3   LHLIYARAANGVIGKDGRLPWHLPQDMAHFRQLTQGCSVIMGRKTWDSLPARFRPLPGRS 62

Query: 59  NIILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           NI+++ Q     D      S+++A+A C       VIGG ++Y Q LP A  + +T I+ 
Sbjct: 63  NIVVTRQSDWHADGARRAASLEQALALCDARQTAWVIGGAQLYAQALPLADCVEVTEINQ 122

Query: 118 EVEGDTHFP 126
           + +GD H P
Sbjct: 123 DFDGDAHAP 131


>UniRef50_D2Q8R3 DfrA Dihydrofolate reductase n=12 Tax=Bifidobacterium
           RepID=D2Q8R3_9BIFI
          Length = 224

 Score = 93.6 bits (231), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 60/144 (41%), Positives = 79/144 (54%), Gaps = 18/144 (12%)

Query: 2   ISLIAALAVDR-----VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RP 53
           ++LI A A D+      IG E  MPW LP D+  F   T++ PVIMGR TWE++    RP
Sbjct: 39  VNLIWAQARDKEGRDGAIGFEGGMPWRLPEDMKHFTELTVSHPVIMGRRTWEALSPKFRP 98

Query: 54  LPGRKNIILSSQPG-TDDRVTWVKSVD--------EAIAACG-DVPEIMVIGGGRVYEQF 103
           LP R NI++S  P  +    T V ++D        EAI   G D  EI +IGG +V+   
Sbjct: 99  LPNRDNIVISHDPAYSAPGATVVDTLDDALDLARQEAIPDDGLDRSEIWIIGGAQVFRDA 158

Query: 104 LPKAQKLYLTHIDAEVEGDTHFPD 127
           LP A K Y+T I   V+ DT+ PD
Sbjct: 159 LPFADKAYVTQISMHVDADTYAPD 182


>UniRef50_D2RRK6 Dihydrofolate reductase n=1 Tax=Haloterrigena turkmenica DSM 5511
           RepID=D2RRK6_9EURY
          Length = 181

 Score = 93.6 bits (231), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 61/168 (36%), Positives = 89/168 (52%), Gaps = 20/168 (11%)

Query: 5   IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNI 60
           I A+A + VIG +  MPW++PADL  FK  T++ P+IMGR T+E I    G PLPGR  +
Sbjct: 19  IVAVADNGVIGKDGDMPWHIPADLKHFKETTMDHPIIMGRVTYEGILEALGEPLPGRTTV 78

Query: 61  ILSSQP-GTDDRVTWVKSVDEAIAACGD--------VPEIMVIGGGRVYEQFLPKAQKLY 111
           +L+S+   T +     +S++EA+ A              I V GG  VYEQFL    +L 
Sbjct: 79  VLTSRDLETPENAVTARSLEEALEAAETAARERHDAADRIFVAGGATVYEQFLSALDRLI 138

Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +T +  E +GDT+FPD++        + F D    +   + F    RR
Sbjct: 139 VTEVHEEPDGDTYFPDWDR-------ASFDDVSRDDRDGFAFVEYVRR 179


>UniRef50_Q03S94 Dihydrofolate reductase n=4 Tax=Lactobacillus RepID=Q03S94_LACBA
          Length = 163

 Score = 93.6 bits (231), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 54/162 (33%), Positives = 86/162 (53%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M+  + A +  RVIG+   +PW+LPAD+ +FK  T    ++ G  T+ S  RPLP RKNI
Sbjct: 1   MLIFLWAESQGRVIGLHGGLPWHLPADMHYFKTVTTGHTIVAGSKTFASFPRPLPNRKNI 60

Query: 61  ILSSQPGT--DDRVTWVKSVD--EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++S QP T   + V+ + S+    A AA     +I V+GG +++   L     LY T ID
Sbjct: 61  VVSHQPATAFPENVSVLHSLPAVRAYAAARPQEKIFVVGGAQLFAGLLDDVDFLYRTRID 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           A  +GDT  P  +   +  +  +    + +N + + FE  +R
Sbjct: 121 AGFDGDTWMPVIDYSQFTLIDQQPGIRNEKNPYDFVFEQYQR 162


>UniRef50_C2HC06 Dihydrofolate reductase n=11 Tax=Enterococcus faecium
           RepID=C2HC06_ENTFC
          Length = 172

 Score = 93.6 bits (231), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 53/161 (32%), Positives = 92/161 (57%), Gaps = 6/161 (3%)

Query: 4   LIAALAVDR--VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
            I+  A DR  +IG    +PW LP D+ +F+ +T+++ ++MGR T+E +G   LP R  I
Sbjct: 2   FISMWAQDRNGLIGKNGLLPWRLPNDMRFFREHTMDRILVMGRKTYEGMGDLSLPYRHII 61

Query: 61  ILSSQPG--TDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +L++QP   T +    + S+DE +A    + E I V GG R++++ LP   +++ T ID+
Sbjct: 62  VLTTQPNFRTKENAEVMHSIDELLAYSQTISEDIYVSGGSRIFQELLPYTGRIWRTLIDS 121

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             EGDT+  D +  D+  +       D +N +++ F+  ER
Sbjct: 122 TFEGDTYIGDIDFSDFALIEEYEGITDQENLYAHRFQKWER 162


>UniRef50_Q3F0Y0 Dihydrofolate reductase n=2 Tax=Bacillus thuringiensis
           RepID=Q3F0Y0_BACTI
          Length = 172

 Score = 93.2 bits (230), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 59/172 (34%), Positives = 83/172 (48%), Gaps = 14/172 (8%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MISLI A   +  IG EN +   L  D+  F + T  KP+IMG  T+ S+G +PL  R N
Sbjct: 1   MISLIVAADENNAIGFENKLLCRLKDDMKHFIKKTKGKPIIMGYKTFASLGHKPLKDRFN 60

Query: 60  IILSSQP-----------GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQ 108
           I+L+  P           G +     ++ +   I    D  EI+VIGG + YE FLP A 
Sbjct: 61  IVLTRSPMALTLDHLHLVGENLVFESLEYIQFMIEQSKD-KEIVVIGGQQTYELFLPMAS 119

Query: 109 KLYLTHIDAEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           ++YLT I     E D++FP  +  +W S     H     N H +     ER+
Sbjct: 120 RVYLTRIHHSFPEADSYFPMLDSSEWSSKLDAKHAESEDNDHPFSIYTFERK 171


>UniRef50_C3XD45 Dihydrofolate reductase n=2 Tax=Oxalobacter formigenes
           RepID=C3XD45_OXAFO
          Length = 163

 Score = 93.2 bits (230), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 58/164 (35%), Positives = 89/164 (54%), Gaps = 15/164 (9%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS + A+A +RVIG +  MPW++P +   F+  T+ K +I+GR T ESIGR LP R  II
Sbjct: 4   ISHVVAMAENRVIGKDGQMPWHIPGEQKIFRELTVGKALILGRKTHESIGRVLPDRITII 63

Query: 62  LSSQ-----PGTDDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S +     PG       V  +DEAI    +    +I++ GGG ++ Q LP   K+YL+ 
Sbjct: 64  VSRKKDYEVPGAH----VVHDIDEAIRLAREFGKEDIVIGGGGELFSQTLPVTDKVYLSI 119

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + A+ +G+T +P+   ++    F E    +   S  Y F   ER
Sbjct: 120 VHADFDGETFYPELPKEE----FVEKARKEIDASIPYAFVEFER 159


>UniRef50_D1PWR8 Dihydrofolate reductase n=1 Tax=Prevotella bergensis DSM 17361
           RepID=D1PWR8_9BACT
          Length = 163

 Score = 92.8 bits (229), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 51/142 (35%), Positives = 79/142 (55%), Gaps = 2/142 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60
           IS+I A+A +R IG  N + ++LP D+  FK  T    +IMGRHT++S+    L  R+NI
Sbjct: 3   ISIIVAMARNRAIGFRNHLLYHLPDDMKHFKALTTGHTIIMGRHTFDSLPNGALLHRRNI 62

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI-DAEV 119
           ++S             S+++AIA+C    E+ +IGG  +Y Q L  A ++YLT + D   
Sbjct: 63  VVSRSRTHIVGCEVFGSLEQAIASCRGEQEVFIIGGESIYRQALAVAHRIYLTLVDDTPT 122

Query: 120 EGDTHFPDYEPDDWESVFSEFH 141
           + DT FP+ +   W+    E H
Sbjct: 123 QFDTVFPEIDMSHWQETKKEKH 144


>UniRef50_D1PCZ0 Dihydrofolate reductase n=1 Tax=Prevotella copri DSM 18205
           RepID=D1PCZ0_9BACT
          Length = 179

 Score = 92.8 bits (229), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 62/184 (33%), Positives = 97/184 (52%), Gaps = 31/184 (16%)

Query: 1   MISLIAALA-VDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRK 58
           M+S+IA ++ V R IG +N + + +P+D+  F+  T    +IMGR T+ES+    LP R+
Sbjct: 1   MLSIIACISKVHRAIGYKNRLLYAIPSDMTRFRMLTTGHTIIMGRKTFESLPNGALPNRR 60

Query: 59  NIILSSQPGTDDRVTWVK---SVDEAIAACGDVP-------------------EIMVIGG 96
           NI++S    T +++T  +   S++EA+AA  +                     E  +IGG
Sbjct: 61  NIVISK---TREQITGCEVYTSLEEALAARKEEAARKEEVGNKETVGSKEASDECFIIGG 117

Query: 97  GRVYEQFLPKAQKLYLTHIDAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEI 155
             +YEQ LP A KLYLT ++ E E  DT FP+  P +WE    E  +   +N   + F  
Sbjct: 118 ASIYEQALPFADKLYLTIVEKEPEHADTFFPEINPAEWEVTEKEMRN---ENGLPFTFLT 174

Query: 156 LERR 159
           L R+
Sbjct: 175 LYRK 178


>UniRef50_P00380 Dihydrofolate reductase n=1 Tax=Enterococcus faecium
           RepID=DYR_ENTFC
          Length = 167

 Score = 92.8 bits (229), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 52/157 (33%), Positives = 91/157 (57%), Gaps = 6/157 (3%)

Query: 4   LIAALAVDR--VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
            I+  A D+  +IG +  +PW LP D+ +F+ +T++K ++MGR T+E +G+  LP R  I
Sbjct: 2   FISMWAQDKNGLIGKDGLLPWRLPNDMRFFREHTMDKILVMGRKTYEGMGKLSLPYRHII 61

Query: 61  ILSSQP--GTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +L++Q     +     + S+DE +A   D+PE I V GG R+++  LP+ + ++ T IDA
Sbjct: 62  VLTTQKDFKVEKNAEVLHSIDELLAYAKDIPEDIYVSGGSRIFQALLPETKIIWRTLIDA 121

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFE 154
           E EGDT   + +   +E V       + +N + + F+
Sbjct: 122 EFEGDTFIGEIDFTSFELVEEHEGIVNQENQYPHRFQ 158


>UniRef50_B7H0P5 Dihydrofolate reductase type 3(Dihydrofolate reductasetype III)
           n=19 Tax=Acinetobacter RepID=B7H0P5_ACIB3
          Length = 181

 Score = 92.8 bits (229), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 57/156 (36%), Positives = 86/156 (55%), Gaps = 9/156 (5%)

Query: 5   IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64
           + A+  +  IG  NA+PW++ ADL  FK  T    VIMGR T ES+GR LP R N +++ 
Sbjct: 11  VVAMDKNHCIGKGNALPWHISADLKHFKEITQGGVVIMGRKTLESMGRALPNRVNWVITR 70

Query: 65  QPGTD-DRVTWVKSVDEAI-AACGDVPE-----IMVIGGGRVYEQFLPKAQKLYLTHIDA 117
                 D V    S+++A+ AA  D        + +IGGG +++Q L  A +L LTH+D 
Sbjct: 71  DINWHFDGVKIAYSIEDALNAALEDAKNTEKQALFIIGGGEIFKQTLSIADRLELTHVDL 130

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCF 153
           +V+GD H+P   P ++    SE    D ++  S+ F
Sbjct: 131 DVQGDAHYPTI-PSEFHKTASE-QQVDEKSGTSFEF 164


>UniRef50_C0EGY7 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum
           DSM 5476 RepID=C0EGY7_9CLOT
          Length = 319

 Score = 92.4 bits (228), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 57/162 (35%), Positives = 87/162 (53%), Gaps = 12/162 (7%)

Query: 1   MISLIAALAVDRV--IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI--GRPLPG 56
           MI +   +AVD+   IG EN + +++P D+A+F++ TLNK V+MGRHT ES+   RPL  
Sbjct: 1   MIKMKCIVAVDQAWGIGCENGLLYSIPEDMAFFRKTTLNKAVVMGRHTLESLPKSRPLKN 60

Query: 57  RKNIILSS----QPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112
           R NI++S     Q G       ++ +  A++ C D  ++ V+GG  VY   L    +  +
Sbjct: 61  RLNIVMSRDRSLQIGGAITCCSLQDLGVALSIC-DSDDVYVMGGYAVYSLLLDFCGQALI 119

Query: 113 THIDAEVEGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCF 153
           T I  + E D  FP+ + D +W    SE  D  + N   Y F
Sbjct: 120 TKIQGQREADRFFPNIDRDNNW--TLSEQSDVRSHNGLCYSF 159


>UniRef50_A0JZC8 Dihydrofolate reductase n=11 Tax=Bacteria RepID=A0JZC8_ARTS2
          Length = 194

 Score = 92.0 bits (227), Expect = 5e-18,   Method: Compositional matrix adjust.
 Identities = 55/137 (40%), Positives = 75/137 (54%), Gaps = 11/137 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           + L+ A     VIG +  MPW+LP D+  F R T   PVIMGR TW S     RPLPGR 
Sbjct: 23  VGLVWAQTTAGVIGKDGDMPWHLPEDMKHFTRLTTGHPVIMGRKTWLSFPDKYRPLPGRT 82

Query: 59  NIILSSQPGTDDR-----VTWVKSVDEAIAACGDVP---EIMVIGGGRVYEQFLPKAQKL 110
           NI+++ Q G  D         VKS+D+A+      P    + V+GGG ++ Q L  A   
Sbjct: 83  NIVVTRQEGWGDTPDARGAIAVKSLDDALLESQFAPGHETVWVLGGGEIFAQTLDIADVA 142

Query: 111 YLTHIDAEVEGDTHFPD 127
            +T ID+E +GDT+ P+
Sbjct: 143 VVTFIDSETDGDTYAPE 159


>UniRef50_C7X688 Dihydrofolate reductase n=7 Tax=Bacteroidales RepID=C7X688_9PORP
          Length = 165

 Score = 92.0 bits (227), Expect = 5e-18,   Method: Compositional matrix adjust.
 Identities = 58/161 (36%), Positives = 85/161 (52%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           IS+IAA+A    IG    +  ++P+D+  FK  T    VIMGR T+ES+   PLP RKN+
Sbjct: 4   ISIIAAIADKSAIGKNQQLLCHMPSDMKRFKELTTGHAVIMGRKTFESLPVAPLPNRKNV 63

Query: 61  ILSSQPGTDDRVTW-VKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L++ P       +  +S+  A+  C    EI +IGG  VY Q L  A K+Y+T I  E 
Sbjct: 64  VLTTMPEAGFVNCFACESMGAALDLCEKEDEIFIIGGALVYRQALRIADKMYITRIHHEF 123

Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +  + FP    D WE    E + AD +N + Y +    R+
Sbjct: 124 PDATSFFPVVNWDLWEETEREEYPADEKNPYPYTYITYVRK 164


>UniRef50_B6YRF0 Dihydrofolate reductase n=1 Tax=Candidatus Azobacteroides
           pseudotrichonymphae genomovar. CFP2 RepID=B6YRF0_AZOPC
          Length = 164

 Score = 92.0 bits (227), Expect = 6e-18,   Method: Compositional matrix adjust.
 Identities = 57/160 (35%), Positives = 85/160 (53%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60
           +S+IA+L  +  IG EN +   LPADL  F++ TL   +IMGR T++S+    LP R+NI
Sbjct: 3   LSIIASLGRNNEIGKENRLLCYLPADLKHFRKITLGHSIIMGRKTFDSLPNGILPDRENI 62

Query: 61  ILSSQPGTDDRVTWV-KSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I+S       +   V  S+D A++   +  E+ +IGG ++Y+Q LP    LYLT + A  
Sbjct: 63  IISRNGSLAIKNARVYTSLDFALSKLMNEEEVFIIGGAQIYQQTLPIVNNLYLTKVYATF 122

Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            E D  FP     +W     E   A+ +N +   F   ER
Sbjct: 123 PEADVFFPLINYSEWHETEQEKIPANTKNPYPISFTKYER 162


>UniRef50_B6BUF2 Dihydrofolate reductase n=1 Tax=beta proteobacterium KB13
           RepID=B6BUF2_9PROT
          Length = 148

 Score = 91.7 bits (226), Expect = 8e-18,   Method: Compositional matrix adjust.
 Identities = 44/129 (34%), Positives = 70/129 (54%), Gaps = 2/129 (1%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67
           ++ + VIG++N++PW+L  DL  FK  T    ++MGR T+ESIG+PLP R N +L+    
Sbjct: 1   MSENNVIGIDNSLPWHLSGDLKRFKAITTGHQIVMGRKTYESIGKPLPNRVNFVLTRN-- 58

Query: 68  TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPD 127
           +D ++  V  +           +  +IGGG +Y Q +    +L +T I  E+ GD  FP 
Sbjct: 59  SDLKIDGVHVISSLNDISDSDKKTFIIGGGEIYSQLIDSCDELLVTKIHREIHGDAFFPM 118

Query: 128 YEPDDWESV 136
            +   W  V
Sbjct: 119 IDASVWSLV 127


>UniRef50_C5CC92 Dihydrofolate reductase n=3 Tax=Actinobacteria (class)
           RepID=C5CC92_MICLC
          Length = 186

 Score = 91.7 bits (226), Expect = 8e-18,   Method: Compositional matrix adjust.
 Identities = 65/181 (35%), Positives = 91/181 (50%), Gaps = 29/181 (16%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           +I++I A    RVIG +  MPW++P DLA F+ +T   PVIMGR TWES     RPLPGR
Sbjct: 11  VIAMIWAQTPGRVIGRDGTMPWHVPEDLAHFRAHTHGHPVIMGRRTWESFPARFRPLPGR 70

Query: 58  KNIILSSQPGTDDRVTWVKSVDEAIAACGD--VPE----------------IMVIGGGRV 99
            NI++S        +T  +     + A G   VP+                + VIGG  +
Sbjct: 71  TNIVVSRT------LTATEQAGAQLRAAGAVVVPDFGAALAAAAEADGCDTVWVIGGATL 124

Query: 100 YEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDA--DAQNSHSYCFEILE 157
           Y+Q L  A +  +T IDA+V+GDTH P  +     +      DA  D+ +   + FE  E
Sbjct: 125 YDQALDVASRAEVTVIDADVDGDTHAPPLDARWRRTAVDPAPDAWLDSASGPRHRFERWE 184

Query: 158 R 158
           R
Sbjct: 185 R 185


>UniRef50_P15093 Dihydrofolate reductase n=3 Tax=Halobacteriaceae RepID=DYR_HALVO
          Length = 162

 Score = 91.3 bits (225), Expect = 8e-18,   Method: Compositional matrix adjust.
 Identities = 50/135 (37%), Positives = 79/135 (58%), Gaps = 5/135 (3%)

Query: 5   IAALAVDRVIGMENAMPW-NLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +AALA +RVIG +  +PW ++PAD   ++    + PV++GR T+ES+   LPG   I++S
Sbjct: 6   VAALAENRVIGRDGELPWPSIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65

Query: 64  --SQPGTDDRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
              +  + D      SV+EA  IAA  D     VIGG  +Y  F P   ++ L+ +  E 
Sbjct: 66  RSERSFSVDTAHRAASVEEAVDIAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEY 125

Query: 120 EGDTHFPDYEPDDWE 134
           EGDT++P+++  +WE
Sbjct: 126 EGDTYYPEWDAAEWE 140


>UniRef50_Q5M5B2 Dihydrofolate reductase n=9 Tax=Streptococcus RepID=Q5M5B2_STRT2
          Length = 167

 Score = 90.5 bits (223), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 56/160 (35%), Positives = 90/160 (56%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKNI 60
           I  I A A + VIG  + MPW+LPA+LA FK+ T+   ++MGR T++ + R  LPGR+ +
Sbjct: 5   IIAIWAEARNHVIGKNHTMPWHLPAELAHFKKTTMGSAILMGRVTFDGMNRRCLPGRETL 64

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           IL+     D + VT V SV+EA+A       ++ + GG  VY+ F      L  T I+A+
Sbjct: 65  ILTRDKDFDCEEVTTVTSVEEALAWFEQQDKDLYIAGGASVYKAFDGHYDVLIKTTIEAD 124

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +EGDT+FP  +   ++ V       + +N++ +     E+
Sbjct: 125 LEGDTYFPQLDTTAFKEVSRNRVPKNEKNAYDFSISRYEK 164


>UniRef50_Q934V0 Putative dihydrofolate reductase n=1 Tax=Salmonella enterica subsp.
           enterica serovar Typhi RepID=Q934V0_SALTI
          Length = 158

 Score = 90.5 bits (223), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 48/127 (37%), Positives = 76/127 (59%), Gaps = 6/127 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + +IAA+  +  IG+ N +PW  P DL  FK+ T N  V+MGR T ES+ RPLP R N++
Sbjct: 1   MKMIAAVGRNYEIGIGNELPWRCPTDLKLFKQLTKNATVVMGRKTMESLKRPLPERHNLV 60

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+   G      +   +D+ +     +P+ + VIGGG++Y  F+P  ++++L+HI  +V 
Sbjct: 61  LTRSRGYIPNGFYPAGIDDVL----RLPDPVWVIGGGQIYSLFMPHVEEIWLSHIGVDVP 116

Query: 121 G-DTHFP 126
           G D  FP
Sbjct: 117 GADAFFP 123


>UniRef50_C8NE93 Dihydrofolate reductase n=24 Tax=Lactobacillales RepID=C8NE93_9LACT
          Length = 169

 Score = 90.5 bits (223), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 12/154 (7%)

Query: 13  VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIILSSQ-----P 66
           ++G +  +PW LP DL +FK  T+ + ++MGR T+E +G R LPGR+ IIL++      P
Sbjct: 13  LVGKDGTLPWRLPNDLKFFKEVTMGQTILMGRKTFEGMGSRLLPGRQTIILTTSSDYIVP 72

Query: 67  GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126
           G +     V +  E I       +I V GG +VY       + LY T I A  EGD++FP
Sbjct: 73  GAE-----VVTNIEEIVEDSRHEDIYVCGGAQVYNLLKNHVELLYCTRIHASFEGDSYFP 127

Query: 127 DYEP-DDWESVFSEFHDADAQNSHSYCFEILERR 159
              P  D+  V S   + D +N + + FEI ER+
Sbjct: 128 TEFPWHDFIKVKSLEGEIDEKNLYPHTFEIYERK 161


>UniRef50_P11731 Dihydrofolate reductase type 5 n=27 Tax=Bacteria RepID=DYR5_ECOLX
          Length = 157

 Score = 90.5 bits (223), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 54/160 (33%), Positives = 94/160 (58%), Gaps = 9/160 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SL+AA A + VIG    +PW+   +   FK  T N+ +++GR T+ES+G  LP RK  +
Sbjct: 3   VSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAV 61

Query: 62  LSSQPGT--DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++    T  +D V    S++EA+    ++ + ++V GGG +Y + LP A  L+++ ID E
Sbjct: 62  VTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIE 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            EGD  FP+  P+ +E VF +   ++     +YC++I ++
Sbjct: 122 PEGDVFFPNI-PNTFEVVFEQHFSSNI----NYCYQIWQK 156


>UniRef50_A9HP20 Dihydrofolate reductase n=1 Tax=Roseobacter litoralis Och 149
           RepID=A9HP20_9RHOB
          Length = 154

 Score = 90.1 bits (222), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 48/132 (36%), Positives = 78/132 (59%), Gaps = 2/132 (1%)

Query: 7   ALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIILSSQ 65
           A A +  IG +  +PWN+P DL +F+R TL   +IMGR+TWES+  +PLP R N+++SS 
Sbjct: 2   ARAENGAIGRDGTIPWNVPEDLKFFQRETLGGALIMGRNTWESLPVKPLPRRFNVVVSSN 61

Query: 66  PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV-EGDTH 124
             T + V     V   +A       I  IGG  +Y++ LP A +L ++ +  +V + DT 
Sbjct: 62  SDTAEVVAPSVKVAIELAIEHGHQRIYGIGGAAIYQEMLPLAHRLLISEVQIDVPDADTF 121

Query: 125 FPDYEPDDWESV 136
           FP+++   W+++
Sbjct: 122 FPNFDVAGWKAI 133


>UniRef50_Q9CBW1 Dihydrofolate reductase n=25 Tax=Actinomycetales RepID=DYR_MYCLE
          Length = 165

 Score = 89.7 bits (221), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 55/146 (37%), Positives = 79/146 (54%), Gaps = 6/146 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           ++ LI A +   VIG +  MPW +P DL  FK+ T+  PV+MGR TW+S+    RPLPGR
Sbjct: 3   VVGLIWAQSTTGVIGRDGGMPWRVPEDLTRFKQLTMGHPVVMGRRTWDSLPVGVRPLPGR 62

Query: 58  KNIILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +NI+LS Q     +      S++E I+     PE+ VIGG ++Y   LP A +  +T +D
Sbjct: 63  RNIVLSRQIDFMAEGAEVFGSLEETISNLETEPEMWVIGGEQIYRLALPLATRCGVTEVD 122

Query: 117 AEV--EGDTHFPDYEPDDWESVFSEF 140
             +  E D        D W  V  E+
Sbjct: 123 TYLLHEDDDVLAPVLDDTWVGVTGEW 148


>UniRef50_C7NFY1 Dihydrofolate reductase n=3 Tax=Actinomycetales RepID=C7NFY1_KYTSD
          Length = 337

 Score = 89.7 bits (221), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 53/148 (35%), Positives = 80/148 (54%), Gaps = 18/148 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++L+ A+A +  IG +  +PW+LP DL  FK  T+   ++MGR T+ES  RPLPGR++++
Sbjct: 168 LTLVVAVARNGAIGRDGDLPWHLPGDLKHFKDTTMGGTMVMGRRTFESFPRPLPGRRHVV 227

Query: 62  LSSQP----------------GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLP 105
           ++S P                   D V   +S  EA+   GD  E+ V+GG  V+   LP
Sbjct: 228 MTSDPTWLPGGPAVEGDPASGARFDEVLVARSWAEALLMAGDG-EVFVVGGAGVFADALP 286

Query: 106 KAQKLYLTHID-AEVEGDTHFPDYEPDD 132
            A +L LT +D +  + DT FP   P D
Sbjct: 287 VADRLVLTEVDQSPQDADTFFPITWPVD 314


>UniRef50_B2GC42 Dihydrofolate reductase n=4 Tax=Lactobacillus RepID=B2GC42_LACF3
          Length = 167

 Score = 89.4 bits (220), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 51/144 (35%), Positives = 79/144 (54%), Gaps = 4/144 (2%)

Query: 14  IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVT 73
           IG +N MPW+L ADL  FK  T   PVIMG++T+ S+GRPLP R NI+++ Q    + VT
Sbjct: 16  IGKDNDMPWHLSADLKHFKHLTSGHPVIMGKNTYLSLGRPLPKRTNIVVTRQTTPIEGVT 75

Query: 74  WVKSVD---EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEP 130
            V  V+   + +A  G+  E+ +IGG  ++   +  A  LY T ++ +  GD      + 
Sbjct: 76  LVNGVNALTDLLANYGEDEEVFIIGGAHLFASTMSLATVLYRTVVEGDHHGDVKMAPIDY 135

Query: 131 DDWESVFSEFHDADAQNSHSYCFE 154
             W+ V +E H    ++  +  FE
Sbjct: 136 RTWQKV-AERHLQATESDPACTFE 158


>UniRef50_D2SDU7 Dihydrofolate reductase n=1 Tax=Geodermatophilus obscurus DSM 43160
           RepID=D2SDU7_9ACTO
          Length = 176

 Score = 89.4 bits (220), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 55/129 (42%), Positives = 79/129 (61%), Gaps = 5/129 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           + L+ A A   VIG +  +PW+LP DL  F+  T    V+MGR TWES+    RPLPGR+
Sbjct: 3   VGLVWAQARGGVIGADGRLPWHLPEDLRLFRELTTGSTVVMGRRTWESLPERFRPLPGRR 62

Query: 59  NIILSS-QPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           N++L++ +    D    V  V++ +A   D  ++ VIGGGRVY  FLP A ++ +T +D 
Sbjct: 63  NVVLTTDRSWAADGAERVDGVEDVLARTDD-GDLWVIGGGRVYAAFLPHADRVVVTDVDT 121

Query: 118 EVEGDTHFP 126
           +VEGDT  P
Sbjct: 122 DVEGDTWAP 130


>UniRef50_Q5WDS2 Dihydrofolate reductase n=3 Tax=Bacillus RepID=Q5WDS2_BACSK
          Length = 162

 Score = 89.4 bits (220), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 52/160 (32%), Positives = 82/160 (51%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI  + A      IG +N +PW+LPADL  FKR T  + ++MGR T++S+G PLP RKN+
Sbjct: 1   MIVFVYARDAHYGIGKDNGLPWHLPADLRHFKRTTTGQTIVMGRKTFDSMGGPLPNRKNV 60

Query: 61  ILS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L+ S+    +    + S+D+ +        I VIGG  ++        K  +T ID + 
Sbjct: 61  VLTRSRSFQAEGAEVIHSLDDVLQLSKQ-EAIYVIGGAEIFALLWDICDKHIVTVIDEKF 119

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E DT  P     +WE V +     D +N + + +    R+
Sbjct: 120 EADTFVPPLSEQEWELVETVPGPIDEKNRYPHEYRTYVRK 159


>UniRef50_B3FJX9 Dihydrofolate reductase n=1 Tax=Pseudomonas phage 201phi2-1
           RepID=B3FJX9_9CAUD
          Length = 183

 Score = 88.6 bits (218), Expect = 6e-17,   Method: Compositional matrix adjust.
 Identities = 49/132 (37%), Positives = 79/132 (59%), Gaps = 14/132 (10%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNII 61
           S+I A  V  VIG++N +PW++PAD+A F  +T  K V+MGR TWES+  +PLPGR NII
Sbjct: 4   SMILARDVQGVIGIDNKLPWHVPADMALFIAHTKGKAVVMGRKTWESLPVKPLPGRHNII 63

Query: 62  LSSQPGTDD-----------RVTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQ 108
           L+ +P   D           +V+   SV++AI +       E++ IGG  +Y+Q +    
Sbjct: 64  LTGKPNYKDVVNAEELTNKAQVSIASSVEDAIISASQEGADEVVFIGGRSIYDQVVNYVD 123

Query: 109 KLYLTHIDAEVE 120
           +++++ ++  VE
Sbjct: 124 EIHVSELNLCVE 135


>UniRef50_Q6CC38 YALI0C12771p n=1 Tax=Yarrowia lipolytica RepID=Q6CC38_YARLI
          Length = 189

 Score = 87.8 bits (216), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 58/147 (39%), Positives = 81/147 (55%), Gaps = 14/147 (9%)

Query: 3   SLIAALAVDRV-IGMENAMPWNLPADLAWFKRNTL---NKPVIMGRHTWESIG---RPLP 55
           +LI A  V R  IG+   +PW L  ++ +FK+ T    N  VIMGR TW+SI    RPLP
Sbjct: 6   TLILAATVPRYGIGLNGGLPWRLAKEMKFFKQVTTAQKNAVVIMGRTTWDSIPPKFRPLP 65

Query: 56  GRKNIILSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL--PKAQKLY 111
            R NI+L+S+P TD  + V   +S DEA+  C +   + VIGG +VY+  L     + + 
Sbjct: 66  DRTNIVLTSRPMTDAPEEVVVARSFDEALTKCPEDSTVYVIGGSQVYKTALVHEHTKAVL 125

Query: 112 LTHI---DAEVEGDTHFPDYEPDDWES 135
           LT I   D  VE DT F  ++   W+ 
Sbjct: 126 LTEITCPDGHVECDTFFEGFDQGLWKK 152


>UniRef50_A4VUL2 Dihydrofolate reductase n=9 Tax=Streptococcus RepID=A4VUL2_STRSY
          Length = 170

 Score = 87.0 bits (214), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 48/153 (31%), Positives = 84/153 (54%), Gaps = 6/153 (3%)

Query: 13  VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIILSSQPG---T 68
           +IG  + +PW+LPADLA FK+ T    ++MGR T++ +G R LP R  I+L++       
Sbjct: 16  LIGKGDRLPWSLPADLAHFKKTTTGHTMVMGRITFDGMGKRALPNRHTIVLTTDKTYQLE 75

Query: 69  DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPD 127
            +R+T + SV++ +       + + VIGGG+++  F P  + L +T I  +  GD +FP 
Sbjct: 76  SERITILHSVEDVLDWYNKQEQTLFVIGGGQIFTAFAPYIETLIVTDIHGQFNGDVYFPK 135

Query: 128 YEP-DDWESVFSEFHDADAQNSHSYCFEILERR 159
             P + ++   +     D +N + +  +  ERR
Sbjct: 136 AFPMEKFQLQSANLRPKDEKNPYDFTIKTYERR 168


>UniRef50_C8NZB9 Dihydrofolate reductase n=1 Tax=Erysipelothrix rhusiopathiae ATCC
           19414 RepID=C8NZB9_ERYRH
          Length = 150

 Score = 87.0 bits (214), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 42/128 (32%), Positives = 75/128 (58%), Gaps = 2/128 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI +I A+   R IG+  +MPW+   DL  F+++TLN+ V+MGR T+E + + L  R+  
Sbjct: 1   MIKIIVAMNNHRTIGLNGSMPWHNKEDLQHFRKSTLNQKVVMGRKTFEGLPKKLDNREIY 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +++     ++ +  +++    +       +I + GGG +Y Q LP A +L +++I  +V 
Sbjct: 61  VVTRNASIENAIPDLRAF--LMQHKESSEDIFIAGGGEIYAQSLPFAHELIISYIPNDVI 118

Query: 121 GDTHFPDY 128
           GDT FPD+
Sbjct: 119 GDTFFPDF 126


>UniRef50_D2LGH8 Dihydrofolate reductase n=1 Tax=Rhodomicrobium vannielii ATCC 17100
           RepID=D2LGH8_RHOVA
          Length = 178

 Score = 87.0 bits (214), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 59/170 (34%), Positives = 90/170 (52%), Gaps = 17/170 (10%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++L+ A A + VIG E  +PW L +DL  F+R T+  P+IMGR T+ SIG+PL GR ++I
Sbjct: 9   LALVVAAAENDVIGREGKLPWRLKSDLKRFRRLTMGHPLIMGRKTFASIGKPLDGRDSVI 68

Query: 62  -------LSSQPGTDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQ 108
                  +S QPG    V    S+ +A+      AA   V E  VIGG  ++   LP A 
Sbjct: 69  VTRDAASVSPQPG----VFVATSIKDALDIARARAAERRVAEAFVIGGAEIFALALPYAD 124

Query: 109 KLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +++L  + A   GD ++     ++W+ V  E   A+  +  S    +LER
Sbjct: 125 RIHLARVHASPSGDAYWQAPPAEEWQVVSREEWPANQTDEFSVTDLVLER 174


>UniRef50_C7R3F1 Dihydrofolate reductase n=1 Tax=Jonesia denitrificans DSM 20603
           RepID=C7R3F1_JONDD
          Length = 191

 Score = 86.3 bits (212), Expect = 3e-16,   Method: Compositional matrix adjust.
 Identities = 56/137 (40%), Positives = 77/137 (56%), Gaps = 9/137 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           +SLI A +++ VIG    +PW+ P DLA F++ T    VIMGRHTWES+   PLP R NI
Sbjct: 11  LSLIWAQSLNGVIGRSGTIPWHEPTDLAHFQKTTRGGVVIMGRHTWESLPVTPLPQRVNI 70

Query: 61  ILSS-----QPGTDDRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +L+S      PG     T  +++D A      G    I VIGG +VY+ F+  A +L +T
Sbjct: 71  VLTSDRDYRAPGARVVTTPQQALDLAHWYTQVGH-QAIWVIGGRQVYDTFMDYATQLIVT 129

Query: 114 HIDAEVEGDTHFPDYEP 130
            +   +EGDT  P   P
Sbjct: 130 TVGTVIEGDTEAPRIPP 146


>UniRef50_C5BYZ5 Dihydrofolate reductase n=1 Tax=Beutenbergia cavernae DSM 12333
           RepID=C5BYZ5_BEUC1
          Length = 169

 Score = 86.3 bits (212), Expect = 3e-16,   Method: Compositional matrix adjust.
 Identities = 54/167 (32%), Positives = 82/167 (49%), Gaps = 15/167 (8%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           MI +I A A D VIG    +PW++P D A FK  T    V+MGR TW+S+    RP+P R
Sbjct: 1   MIGMIWAQAHDGVIGARGTVPWHVPEDFAHFKATTRGHAVVMGRATWDSLPDRYRPMPER 60

Query: 58  KNIILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +N++++ Q   + D      S+ +A+  C   PE  ++GG ++Y + +P A  L +T +D
Sbjct: 61  RNVVVTRQVDWSADGAERAGSIPDALERCAAEPETWIMGGAQIYAEAMPYADTLVVTQLD 120

Query: 117 --AEVEGD---THFPDYEP------DDWESVFSEFHDADAQNSHSYC 152
              +VEG     H P   P      D W+  +           H Y 
Sbjct: 121 LALDVEGAPDVVHAPPIGPEWRIATDTWDGTWQTSRTGVRWQVHQYV 167


>UniRef50_Q0G0R9 Dihydrofolate reductase n=2 Tax=Aurantimonadaceae
           RepID=Q0G0R9_9RHIZ
          Length = 178

 Score = 85.9 bits (211), Expect = 4e-16,   Method: Compositional matrix adjust.
 Identities = 49/129 (37%), Positives = 70/129 (54%), Gaps = 7/129 (5%)

Query: 5   IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64
           + A A + VIG +  MPW++P+DL  ++  T+ KP+IMGR T E+IG+ L GR +I+L+ 
Sbjct: 11  VVAAAKNGVIGADGGMPWSIPSDLKRYRSLTMGKPMIMGRKTLEAIGKALDGRDSIVLTR 70

Query: 65  QPGTD-DRVTWVKSVDEAIAA---CGD---VPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +     D         EAIA    C       EI V+GG  +Y        ++ LT +DA
Sbjct: 71  ENRLAVDGAMLASGPAEAIAKAIECASARRASEIAVVGGAEIYRLLWDHIDRIALTEVDA 130

Query: 118 EVEGDTHFP 126
           E EGD  FP
Sbjct: 131 EPEGDAVFP 139


>UniRef50_B2GI60 Dihydrofolate reductase n=3 Tax=Actinomycetales RepID=B2GI60_KOCRD
          Length = 183

 Score = 85.9 bits (211), Expect = 4e-16,   Method: Compositional matrix adjust.
 Identities = 61/150 (40%), Positives = 83/150 (55%), Gaps = 25/150 (16%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           M+  I A + D VIG++  +PW+L  DL +F R T+  PVIMGR TWES     RPLPGR
Sbjct: 1   MVGAIWAQSPDGVIGVDGGIPWHLSEDLKFFARTTIGHPVIMGRRTWESFPEQFRPLPGR 60

Query: 58  KNIILSSQPGT----DDRVTWVKSVDEA-------IAACG-----DVPEIMVIGGGRVYE 101
            NI+++S+P +     +RV  V S  EA       +AA G        E+ VIGG  V+ 
Sbjct: 61  PNIVITSRPESVPADGERVWAVGSYAEALELAVSLLAAPGPEHEEPAREVWVIGGPGVWR 120

Query: 102 QF-----LPKAQKLYLTHIDAEVEGDTHFP 126
           +      LP  + L +T +D +V GDTH P
Sbjct: 121 EAVSHRPLPLTRAL-VTTVDLDVTGDTHAP 149


>UniRef50_C3PEY4 Dihydrofolate reductase n=9 Tax=Corynebacterium RepID=C3PEY4_CORA7
          Length = 181

 Score = 85.9 bits (211), Expect = 4e-16,   Method: Compositional matrix adjust.
 Identities = 56/132 (42%), Positives = 77/132 (58%), Gaps = 8/132 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           M+  I A ++D VIG    MPW++P DL  FK  T+  PVIMGR TWES+    RPLPGR
Sbjct: 1   MLGAIWAQSLDGVIGDGVVMPWHVPEDLKHFKEVTMGAPVIMGRKTWESLTPKFRPLPGR 60

Query: 58  KNIILS-SQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
            NI+LS  +PG      T V ++D A+ A  D  +  +IGGG++Y   L +   + LT +
Sbjct: 61  DNIVLSRREPGEWSAGATVVDNLDAALHATLD--DAWIIGGGQLYSSALDRVDTIELTLM 118

Query: 116 DAEVEGDTHFPD 127
             +V GD +  D
Sbjct: 119 GVQV-GDAYGAD 129


>UniRef50_C7H0N2 Dihydrofolate reductase n=1 Tax=Eubacterium saphenum ATCC 49989
           RepID=C7H0N2_9FIRM
          Length = 162

 Score = 85.5 bits (210), Expect = 5e-16,   Method: Compositional matrix adjust.
 Identities = 55/160 (34%), Positives = 84/160 (52%), Gaps = 8/160 (5%)

Query: 6   AALAVDR--VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI--GRPLPGRKNII 61
           A + VD+   IG +  +  +L  DL +FK  T+ K +I+GR T ES   G+PLPGRK I+
Sbjct: 3   AIVVVDKNWCIGKDGGLLVHLSKDLKYFKEKTIGKTLIVGRKTLESFPGGKPLPGRKTIV 62

Query: 62  LSSQPGTDDRVTWV-KSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           L+          +V  S  E +    D+   ++ V GGG +Y+QFL    K ++T I  E
Sbjct: 63  LTRNTSYKAEGAYVCHSKQEVLEKVKDLHPADVFVAGGGAIYKQFLNDVDKGFVTKICNE 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             GDT FP+ + D+  ++ SE  +   +N   + F I  R
Sbjct: 123 YSGDTFFPNLDEDEDFALESE-GETIEENGVKFKFCIYNR 161


>UniRef50_P78218 Dihydrofolate reductase type 15 n=153 Tax=root RepID=DYR15_ECOLX
          Length = 157

 Score = 85.5 bits (210), Expect = 5e-16,   Method: Compositional matrix adjust.
 Identities = 53/160 (33%), Positives = 94/160 (58%), Gaps = 9/160 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SL+AA++ + VIG    +PW+   +   FK  T N+ +++GR T+ES+G  LP RK  +
Sbjct: 3   LSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMG-ALPNRKYAV 61

Query: 62  L--SSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +  SS   +D+ V    S+DEA+     + + ++V GGG +Y+  + K   L+++ ID E
Sbjct: 62  VTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDIE 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            EGD +FP+  P  +  VFS+    D  ++ +Y ++I ++
Sbjct: 122 PEGDVYFPEI-PSSFRPVFSQ----DFVSNINYSYQIWQK 156


>UniRef50_C8WCM1 Dihydrofolate reductase region n=4 Tax=Zymomonas mobilis
           RepID=C8WCM1_ZYMMN
          Length = 165

 Score = 85.1 bits (209), Expect = 7e-16,   Method: Compositional matrix adjust.
 Identities = 52/124 (41%), Positives = 73/124 (58%), Gaps = 2/124 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I LI A A + VIG +N MPW++ ADL  FK  TL  P+IMGR T+ES+   LP R +I+
Sbjct: 7   IMLIFARAQNGVIGKDNTMPWHISADLKHFKALTLGHPMIMGRRTFESLPGLLPKRPHIV 66

Query: 62  LS-SQPGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           L+ +     +    V  ++EAI A      +I VIGG  +++QF  KA ++ LT I  + 
Sbjct: 67  LTHNHHWQAEGAEVVCDLEEAIKAARKYSSQIAVIGGANIFQQFWDKADRIELTEIYRDY 126

Query: 120 EGDT 123
            GDT
Sbjct: 127 SGDT 130


>UniRef50_Q8EV82 Dihyrofolate reductase n=1 Tax=Mycoplasma penetrans
           RepID=Q8EV82_MYCPE
          Length = 154

 Score = 84.7 bits (208), Expect = 8e-16,   Method: Compositional matrix adjust.
 Identities = 47/137 (34%), Positives = 74/137 (54%), Gaps = 20/137 (14%)

Query: 11  DRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD 70
           +R IG  N +PWN+  DL  FK++TLN  ++MG++T+ SIG+ LP RKNI++S       
Sbjct: 11  NRGIGKNNKLPWNIKEDLNLFKKHTLNNTIVMGKNTFLSIGKALPNRKNIVISK------ 64

Query: 71  RVTWVKSVDEAIAACGDVPE-----------IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
             T   S+ + I    D+ +           I +IGG  +Y+ F+ K   LY++ +++  
Sbjct: 65  --TLDASLYKDIEVYDDIEQFYNEYKNRDESIFIIGGKSIYDYFINKCSILYVSKLNSAY 122

Query: 120 EGDTHFPDYEPDDWESV 136
           E D  F D   D +E V
Sbjct: 123 ECDL-FMDNSFDGFEIV 138


>UniRef50_Q14P23 Putative dihydrofolate reductase oxidoreductase protein n=1
           Tax=Spiroplasma citri RepID=Q14P23_SPICI
          Length = 160

 Score = 84.7 bits (208), Expect = 8e-16,   Method: Compositional matrix adjust.
 Identities = 44/141 (31%), Positives = 77/141 (54%), Gaps = 5/141 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI L+ A+  + +IG  + +PW+L  +L  FK  TL + ++ GR T+E IG PLP RK +
Sbjct: 1   MIKLLWAMDENNLIGQNDQLPWHLREELQHFKETTLGQTILFGRLTYEGIGWPLPKRKTL 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAAC-----GDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           +L+       +   V+ V +  A           +I + GG ++YE  LP A +L ++ I
Sbjct: 61  VLTRHLDYQIKHPDVEVVTDLTAIINFYHQNPTEDIYICGGKKIYEATLPYADELIISLI 120

Query: 116 DAEVEGDTHFPDYEPDDWESV 136
             + +GDT+FP ++ + +  +
Sbjct: 121 KGKYQGDTYFPSFDLNQFTLI 141


>UniRef50_Q7NHQ9 Dihydrofolate reductase n=1 Tax=Gloeobacter violaceus
           RepID=Q7NHQ9_GLOVI
          Length = 169

 Score = 84.0 bits (206), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 52/133 (39%), Positives = 78/133 (58%), Gaps = 9/133 (6%)

Query: 2   ISLIAALAVD--RVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLP 55
           + LIA +A+D  R+IG  + +PW+ P DL+ FK  T  +P++MGR T+ESI    G+PLP
Sbjct: 1   MELIAVVAMDSRRLIGRGDGLPWHCPEDLSAFKALTWGQPLLMGRRTFESILARRGKPLP 60

Query: 56  GRKNIILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
            R++ +L+++ G     V ++ S D+A+A    V  + VIGG  VY Q   +   LYL+ 
Sbjct: 61  EREHYVLTARRGPSFPTVRYICSPDQALAL--PVERLFVIGGASVYAQTADQLDTLYLSL 118

Query: 115 IDAEVEGDTHFPD 127
           I     GD   PD
Sbjct: 119 IPGLHTGDVFLPD 131


>UniRef50_C9MLK6 Dihydrofolate reductase n=2 Tax=Prevotella RepID=C9MLK6_9BACT
          Length = 161

 Score = 83.6 bits (205), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 52/144 (36%), Positives = 74/144 (51%), Gaps = 2/144 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           +++IAA+A +R IG  N M + +  DL  FK+ T    VIMGR T+ S+ +  LP R+NI
Sbjct: 3   LNIIAAVAANRAIGYRNDMVYFIREDLKRFKQLTTGHTVIMGRKTFHSLPKGALPNRRNI 62

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI-DAEV 119
           +LS             S+DEA+       +  +IGG  +Y++ L  A +LYLT I D   
Sbjct: 63  VLSRTEKDFKGCEVYPSLDEAMRHIHADEQAFIIGGASLYKEALGIANRLYLTEIADTPA 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDA 143
           + D  FP Y    W     E H A
Sbjct: 123 QADVFFPPYNDGTWRVESREEHPA 146


>UniRef50_B1V8Y8 Dihydrofolate reductase n=6 Tax=Candidatus Phytoplasma
           RepID=B1V8Y8_PHYAS
          Length = 165

 Score = 83.6 bits (205), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 46/147 (31%), Positives = 77/147 (52%), Gaps = 21/147 (14%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-----RPLP 55
           MI+LI A   + +IG +N +PW+ P DL +FK+ TLN+ V+MG  T+ S+      +P  
Sbjct: 1   MINLITAFDSNYLIGSDNKLPWHYPQDLHFFKKTTLNQEVLMGHQTYLSLKSYFKDKPFN 60

Query: 56  GRKNIILSSQPGTD--------DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKA 107
            +K  + +   G          D +T++K+             + VIGG ++Y+Q LP  
Sbjct: 61  FKKTYVAARNKGLQLDGCEVVFDLLTFLKTF-----LIQKKSHLFVIGGRQIYQQSLPFV 115

Query: 108 QKLYLTHIDAEVEGDTHFPDYEPDDWE 134
             LY+T+I    +G+ +FP   P +W+
Sbjct: 116 DNLYITYILNRHKGNVYFP---PVNWQ 139


>UniRef50_A4GI75 Dihydrofolate reductase n=1 Tax=uncultured marine bacterium
           HF10_29C11 RepID=A4GI75_9BACT
          Length = 168

 Score = 83.6 bits (205), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 56/169 (33%), Positives = 86/169 (50%), Gaps = 14/169 (8%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL---NKPVIMGRHTWESI---GRPL 54
           M+ +I A+ +D  IG EN +PW L +D+  FKR T+   N  V+MGR TWE+I    RPL
Sbjct: 2   MLKMILAMDLDGCIGKENGLPWRLQSDMLRFKRLTIGQGNSAVLMGRTTWETIPERFRPL 61

Query: 55  PGRKNIILSSQPG---TDDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQK 109
             R NI+++       +D  VT+  S++  I  A+  +  E  +IGG  VYEQ      +
Sbjct: 62  VDRINIVVTRNRNYALSDAHVTY--SIENGIEHASNNNCDECWIIGGADVYEQCRDLVDE 119

Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           ++LT ++    GD     +  D+W     E     + N H   + IL +
Sbjct: 120 IHLTSVETSNSGDIKVGMF-GDEWNREIIESTPESSDNEHPTTYMILRK 167


>UniRef50_B7VPW7 Dihydrofolate reductase type I (Trimethoprim resistance) n=2
           Tax=Vibrio splendidus RepID=B7VPW7_VIBSL
          Length = 183

 Score = 83.6 bits (205), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 50/160 (31%), Positives = 89/160 (55%), Gaps = 9/160 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SL+AA+A + VIG    +PW +  +   FK  T N+ +++GR T+ES+G+ LP RK  +
Sbjct: 29  LSLMAAVAENGVIGSGLDIPWIVKGEQLLFKAMTFNQWLLLGRKTFESMGK-LPNRKYAV 87

Query: 62  LSSQPGT--DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +S  P T  D  + + KSV++A+     V E   V GGG++Y+  + +   ++++ I   
Sbjct: 88  ISRSPSTSNDPDILYFKSVEDALGYLETVTEHAFVSGGGQIYKSLITQVDTIHISKIHKH 147

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + GD  FP+  P D   VF +   ++      Y ++I ++
Sbjct: 148 ISGDIFFPEL-PRDLTLVFEQRFSSNID----YTYQIWQK 182


>UniRef50_UPI0001926A4C PREDICTED: similar to Dihydrofolate reductase CG14887-PB n=1
           Tax=Hydra magnipapillata RepID=UPI0001926A4C
          Length = 189

 Score = 83.6 bits (205), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 59/176 (33%), Positives = 89/176 (50%), Gaps = 22/176 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL-------NKPVIMGRHTWESI---G 51
           +  IAA+  +  IG++  +PWNLP +  +F+  T           VIMG++TW SI    
Sbjct: 7   VHCIAAIDSEWGIGLKGKLPWNLPREYKFFQNITTKVISEGKQNAVIMGKNTWFSIPQQH 66

Query: 52  RPLPGRKNIILSSQPGTDD---RVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQ 102
           RPL  R N+ILSS    +D    V    S++ AI    D      V  I VIGG RVY++
Sbjct: 67  RPLKNRLNVILSSSFIKEDYPKNVLLESSLEAAILRLSDEFYANTVENIFVIGGSRVYKE 126

Query: 103 FLPK-AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQ--NSHSYCFEI 155
            + K   K+YLT I+ +   D  +P ++ + ++ +  E  D + Q  N  SY F +
Sbjct: 127 AMEKFCDKIYLTKIEQDYSCDVFYPIFDTNKFKEIDDEEVDKNKQIENGVSYTFHV 182


>UniRef50_C1C2C0 Dihydrofolate reductase n=1 Tax=Caligus clemensi RepID=C1C2C0_9MAXI
          Length = 178

 Score = 83.6 bits (205), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 49/134 (36%), Positives = 74/134 (55%), Gaps = 11/134 (8%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKP-----VIMGRHTWESIG---RPLP 55
           + AA    R IG +N +PW LP D+ +F+  T +       VIMGR TWES+    RP  
Sbjct: 12  IAAACKSSRGIGKDNDLPWKLPTDMKYFREKTASTTEIRVGVIMGRRTWESVPPKFRPFK 71

Query: 56  GRKNIILSSQPGTDDR-VTWVKSVDEAIAACG-DVPEIMVIGGGRVYEQFLPK-AQKLYL 112
            R N++L+S+   + +     +++++A+  C  +V  I VIGG  VY + L K   ++YL
Sbjct: 72  NRFNVVLTSREDFEAKGAVIARTLEDAVKKCSNNVDSIWVIGGSGVYAEALNKYPCRVYL 131

Query: 113 THIDAEVEGDTHFP 126
           T ID E + D  FP
Sbjct: 132 TEIDKEFDCDAFFP 145


>UniRef50_A6DQ18 Dihydrofolate reductase region n=1 Tax=Lentisphaera araneosa
           HTCC2155 RepID=A6DQ18_9BACT
          Length = 149

 Score = 83.2 bits (204), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 46/135 (34%), Positives = 78/135 (57%), Gaps = 6/135 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M+SLI+A+  + +IG   A+PW +  +   +      K +I+GR T+E  G  L   +  
Sbjct: 1   MLSLISAMDKNGLIGTGKALPWKVEEEYQRYLDTVKGKKIIVGRKTFEISGLDLKDEQVH 60

Query: 61  ILSSQP-GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ILSS+  GT+    +  ++++AI ACG+  +I V GG  VY+  +P A +LY++ I  + 
Sbjct: 61  ILSSRSQGTN----YYNNIEDAIKACGE-NDIFVTGGAEVYKLAMPHADRLYISVIKGDY 115

Query: 120 EGDTHFPDYEPDDWE 134
           EG  +FP+ + + WE
Sbjct: 116 EGSIYFPNIDANIWE 130


>UniRef50_Q59487 Dihydrofolate reductase n=17 Tax=Streptococcaceae RepID=DYR_LACLA
          Length = 168

 Score = 82.8 bits (203), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 47/152 (30%), Positives = 86/152 (56%), Gaps = 6/152 (3%)

Query: 13  VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIILS---SQPGT 68
           +IG  + MPW+LPA+   FK  T+N+ ++MGR T+E +  R LPGR +IIL+   +    
Sbjct: 13  LIGEADKMPWSLPAEQQHFKETTMNQVILMGRKTFEGMNKRVLPGRISIILTRDETYQSD 72

Query: 69  DDRVTWVKSVDEAIA-ACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPD 127
           +++V  + S  E +        ++ + GG  +   F  + + LY T +  + +GDT+FP 
Sbjct: 73  NEKVLIMHSPKEVLDWYHKQNKDLFITGGAEILALFESELELLYRTVVHEKFKGDTYFPS 132

Query: 128 -YEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            ++   ++ V  +FHD D +NS+++  +  E+
Sbjct: 133 TFDFGRFKLVSEKFHDKDERNSYTFTIKKYEK 164


>UniRef50_Q8JKV3 Dihydrofolate reductase n=1 Tax=Heliothis zea virus 1
           RepID=Q8JKV3_9VIRU
          Length = 264

 Score = 82.4 bits (202), Expect = 5e-15,   Method: Compositional matrix adjust.
 Identities = 60/151 (39%), Positives = 83/151 (54%), Gaps = 16/151 (10%)

Query: 2   ISLIAALAVDRV-IGMENAMPWNLPADLAWFKRNTL-----NK-PVIMGRHTWESIG--- 51
           I+LI A+  + + IGM NA+PW+L  ++A F + T      NK  VIMGR TWESI    
Sbjct: 87  INLIVAVCENNMGIGMNNALPWHLKREMAHFTKTTTTATHPNKNAVIMGRLTWESIPKRF 146

Query: 52  RPLPGRKNIILSSQPGTD-DRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFL--P 105
           RPLPGR NI+L+++   D D  T V + DEAI      GD+    VIGG  VY   +  P
Sbjct: 147 RPLPGRVNIVLTTKHRGDYDGATRVSNFDEAIRVVESRGDIETAWVIGGASVYAAAMTHP 206

Query: 106 KAQKLYLTHIDAEVEGDTHFPDYEPDDWESV 136
              +++LT I    E +  FP  +   +E +
Sbjct: 207 NCHQIHLTAIKKYYECNVFFPKIDTTRFELI 237


>UniRef50_C5VBQ6 Dihydrofolate reductase n=5 Tax=Corynebacterium RepID=C5VBQ6_9CORY
          Length = 160

 Score = 82.0 bits (201), Expect = 5e-15,   Method: Compositional matrix adjust.
 Identities = 53/120 (44%), Positives = 70/120 (58%), Gaps = 12/120 (10%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           M+  I A  +  +IG   +MPW++P DL  FK+ TL  P+IMGR TWES+  RPLPGRKN
Sbjct: 1   MLRAIWAQNLMGLIGDGKSMPWHVPEDLQHFKKLTLGSPIIMGRRTWESLPVRPLPGRKN 60

Query: 60  IILSSQ-PGTDDRVTWVKSVDEAIAACGDVPEI-MVIGGGRVYEQFLPKAQKLYLTHIDA 117
           ++LS + PG      W        +    VPE   VIGGG VY   + K Q+++ T IDA
Sbjct: 61  LVLSRRTPG-----KW----SNGASVIASVPESGWVIGGGVVYAATIDKVQEIHRTLIDA 111


>UniRef50_D1BYH5 Dihydrofolate reductase n=1 Tax=Xylanimonas cellulosilytica DSM
           15894 RepID=D1BYH5_XYLCX
          Length = 185

 Score = 82.0 bits (201), Expect = 5e-15,   Method: Compositional matrix adjust.
 Identities = 56/156 (35%), Positives = 77/156 (49%), Gaps = 23/156 (14%)

Query: 1   MISLIAALAVDR----VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLP 55
           MI+LI A A D     VIG    +PW +  D   F+  T   PV+MGR TW+S+  RPLP
Sbjct: 1   MIALIWAQARDTAGRPVIGAGGDIPWRVAEDFTRFRTLTTGHPVVMGRRTWDSLPRRPLP 60

Query: 56  GRKNIILSSQPG--TDD-------------RVTWVKSVDEAIAACGDVPE---IMVIGGG 97
           GR N++++ QP    DD              V    ++DEA+      P    + +IGG 
Sbjct: 61  GRTNVVVTRQPDWRPDDDGAVVTAGAPEATAVVVATTLDEALDGATQAPGGDLVWIIGGA 120

Query: 98  RVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDW 133
            +Y Q L  A +L +T ID  V+GD   P  +P  W
Sbjct: 121 EIYGQALAVADRLEVTEIDLVVDGDAFAPAIDPVHW 156


>UniRef50_D0NVQ6 Putative uncharacterized protein n=1 Tax=Phytophthora infestans
           T30-4 RepID=D0NVQ6_PHYIN
          Length = 174

 Score = 82.0 bits (201), Expect = 5e-15,   Method: Compositional matrix adjust.
 Identities = 47/145 (32%), Positives = 83/145 (57%), Gaps = 18/145 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAA +V+RVIG +  +PWNLPAD A+F   T N+ +++GR ++E    P+P R  I+
Sbjct: 8   VSLIAACSVNRVIGKQGRLPWNLPADWAFFSTATQNQVLVVGRRSFEEFDEPIPNRHTIV 67

Query: 62  LSSQ------PGTDDR---VTWVKSVDEAIAACGDVPE------IMVIGGGRVYEQFLPK 106
           +SS         T+ R   V + +++++A+      P+      + V GG R+Y++ +  
Sbjct: 68  VSSTLQKLQVDATNARWPSVQFARTLEQALQLANTDPQYRNCNRVFVGGGERLYKEAMDS 127

Query: 107 --AQKLYLTHIDAEV-EGDTHFPDY 128
             A   Y++ +   + +GDT FP++
Sbjct: 128 EVADSCYVSRVHQYITDGDTFFPEW 152


>UniRef50_C5RC79 Dihydrofolate reductase n=1 Tax=Weissella paramesenteroides ATCC
           33313 RepID=C5RC79_WEIPA
          Length = 168

 Score = 82.0 bits (201), Expect = 5e-15,   Method: Compositional matrix adjust.
 Identities = 50/153 (32%), Positives = 82/153 (53%), Gaps = 4/153 (2%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNII 61
           +LI A  +D  I ++  +PW+  ADL +FK++T+++  +MGRHT  S  GRPLP R N++
Sbjct: 8   NLIWAQTLDGTIAIDGHIPWHQKADLQFFKQSTIHEAALMGRHTMASFHGRPLPERLNLV 67

Query: 62  LSSQPGTD--DRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           L+     +  +    V SV EA     +   ++ VIGG  +YE F+  A  LY+T++  +
Sbjct: 68  LTRNHDLEVPEGFQKVYSVAEAEKVADNANLKLQVIGGKPIYESFMDTADTLYVTYLQTD 127

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSY 151
             GD      +   W+    +   ADA N + +
Sbjct: 128 FSGDVKMAPVDLTVWQGEVIDQGPADADNDYDW 160


>UniRef50_C7P3D4 Dihydrofolate reductase region n=1 Tax=Halomicrobium mukohataei DSM
           12286 RepID=C7P3D4_HALMD
          Length = 157

 Score = 81.6 bits (200), Expect = 6e-15,   Method: Compositional matrix adjust.
 Identities = 48/140 (34%), Positives = 76/140 (54%), Gaps = 7/140 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I  +AA+  + VIG  + +PW+LP +   ++    +  V++GR T+E     LPG + ++
Sbjct: 3   IIAVAAVGENGVIGSGDELPWHLPHESRRYRERVADDTVVLGRKTFEMF-EELPGARQLV 61

Query: 62  LSSQPGT--DDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           LS    +   +  T   SVD AI      GD P + V+GG  VYE FLP+  ++ L+ +D
Sbjct: 62  LSRSERSFEAETATHAASVDAAIDLARERGD-PVLYVLGGAGVYEAFLPRYDRMLLSRVD 120

Query: 117 AEVEGDTHFPDYEPDDWESV 136
            E EGD  FP ++ + W  V
Sbjct: 121 GEYEGDATFPAFDREAWTLV 140


>UniRef50_Q59397 Dihydrofolate reductase type 9 n=1 Tax=Escherichia coli
           RepID=DYR9_ECOLX
          Length = 177

 Score = 81.6 bits (200), Expect = 6e-15,   Method: Compositional matrix adjust.
 Identities = 52/136 (38%), Positives = 73/136 (53%), Gaps = 11/136 (8%)

Query: 1   MISLIAALAVDRV--IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRK 58
           M SL   +AV++   IG EN +PW+ P DL  FK  T+N  +IMGR T+ S+ + LPGR 
Sbjct: 1   MASLNMIVAVNKTGGIGFENQIPWHEPEDLKHFKAVTMNSVLIMGRKTFASLPKVLPGRL 60

Query: 59  NIILS-SQPGTD--DRVTWVKSVDEAIAACG---DVPE---IMVIGGGRVYEQFLPKAQK 109
           ++++S + P T   D+V +V +   A+       D PE   I VIGG   YE       K
Sbjct: 61  HVVVSKTVPPTQNTDQVVYVSTYQIAVRTASLLVDKPEYSQIFVIGGKSAYENLAAYVDK 120

Query: 110 LYLTHIDAEVEGDTHF 125
           LYLT +    + DT  
Sbjct: 121 LYLTRVQLNTQQDTEL 136


>UniRef50_C2CWT0 Dihydrofolate reductase n=1 Tax=Gardnerella vaginalis ATCC 14019
           RepID=C2CWT0_GARVA
          Length = 210

 Score = 81.3 bits (199), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 53/159 (33%), Positives = 79/159 (49%), Gaps = 24/159 (15%)

Query: 14  IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRKNIILSSQPG-TD 69
           +G+   MPW L  DL +FK  T++ PVIMGR TW+S+    RPLPGR+NI++S  P    
Sbjct: 24  MGVNGGMPWRLSTDLRYFKAMTISCPVIMGRGTWDSMPEKFRPLPGRENIVVSRNPDFNS 83

Query: 70  DRVTWVKSVDEAIAAC--------------GDVPE----IMVIGGGRVYEQFLPK--AQK 109
           D      S++EAI                  D+P+    + +IGGG ++ + +       
Sbjct: 84  DGAKSFTSIEEAICYAKKWIEDNPIEHVDSSDLPKDGSAVWIIGGGAIFREVIESQIVDA 143

Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNS 148
            Y+T ID  VE DT  P+ +    + ++    D D Q S
Sbjct: 144 AYVTQIDTRVEADTFAPNIQKLVDDGLWKVARDCDWQES 182


>UniRef50_D2NRG7 Dihydrofolate reductase n=2 Tax=Rothia mucilaginosa
           RepID=D2NRG7_9MICC
          Length = 222

 Score = 80.5 bits (197), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 58/180 (32%), Positives = 81/180 (45%), Gaps = 43/180 (23%)

Query: 13  VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRKNIILS---SQP 66
           +IG    MPW  P DLA FK+ TL  PVIMGR TWES     RPLPGR NI++S   ++ 
Sbjct: 16  IIGRAGDMPWYAPEDLAHFKKVTLGAPVIMGRRTWESFPPRFRPLPGRTNIVISRSVTEA 75

Query: 67  GTDDRVTWVKSVDEAIAA----------------CGDVPEI--MVIGGGRVYEQFLPK-- 106
              D   WV S+D A+ A                  D P +   +IGGG VY + L +  
Sbjct: 76  EERDGALWVPSLDAALYAARDAVGAPVEATPADTATDAPAVDAWIIGGGSVYAEALSRND 135

Query: 107 ----------AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
                      + L+      E+ GDT  P+ +        ++ H   A  S + C+ ++
Sbjct: 136 LPAFGRVKTVERTLFYCQEGNEITGDTRAPELQ-------LADSHGNCATGSPNGCWHVV 188


>UniRef50_C0VZ67 Possible dihydrofolate reductase n=3 Tax=Actinomycetaceae
           RepID=C0VZ67_9ACTO
          Length = 170

 Score = 80.5 bits (197), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 52/151 (34%), Positives = 86/151 (56%), Gaps = 8/151 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR--PLPGRK 58
           ++ +I A   +  +G  + M W++PAD   FK++T+  P+IMGR +W+++GR  PLP R+
Sbjct: 3   VVKMIWAQDAEGKLGSGSEMLWHVPADFRHFKQSTVGFPLIMGRKSWDALGRFAPLPQRR 62

Query: 59  NIILSSQPGTDDRVTWVK-SVDEAIA-ACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           NI+++           V  S++EAI+ A  D   + + GG  +YEQ +P A +L +T++D
Sbjct: 63  NIVVTRNRDFIPEGGEVAFSIEEAISLASADSELVWIAGGAHIYEQAMPFADELVVTYLD 122

Query: 117 AEVEGD---THFPDYEPDDWESVFSEFHDAD 144
             V       + P  +P  WE V +E  DAD
Sbjct: 123 LNVSTAGPVVYAPQIDPAVWEVVKAE-SDAD 152


>UniRef50_B3RI81 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3RI81_TRIAD
          Length = 174

 Score = 80.5 bits (197), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 56/185 (30%), Positives = 84/185 (45%), Gaps = 46/185 (24%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESI---GRPLPGR 57
           +  DR IG +N +PW L  +  +F R T +         V+MGR+TW SI    RPL  R
Sbjct: 1   MTRDRGIGYKNDLPWKLRNEYKYFARLTTSTKDSAKKNAVLMGRNTWVSIPEKNRPLRNR 60

Query: 58  KNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIM----------------VIGGGRVYE 101
            NI++SSQ   ++       V E +     +PE++                ++GG  VY+
Sbjct: 61  INIVISSQLRAEE-------VPEGVHVVASIPEVIELVQSPLLKDIVETVWIVGGAPVYK 113

Query: 102 QFL--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADA------QNSHSYCF 153
            F+  P+  ++YLT +DA  E D  FP+   D     F E  D D       +N   Y F
Sbjct: 114 GFMSHPQCDRIYLTKLDANYECDVFFPEMSDD-----FKEISDPDVSQEVQEENGLKYTF 168

Query: 154 EILER 158
            + +R
Sbjct: 169 HVYQR 173


>UniRef50_Q6BTR6 DEHA2C16456p n=2 Tax=Debaryomyces hansenii RepID=Q6BTR6_DEBHA
          Length = 206

 Score = 80.1 bits (196), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 59/155 (38%), Positives = 80/155 (51%), Gaps = 25/155 (16%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG---RP 53
           ++AAL  +  IG++  MPW L  ++ +FK  T           VIMGR TWESI    RP
Sbjct: 15  IVAALLPELGIGIKGKMPWRLRQEIKYFKNVTTTTKDPNGINAVIMGRKTWESIPTKFRP 74

Query: 54  LPGRKNIILS----SQPGTDDRVTWVKSVDEAIAACGD----VPEIMVIGGGRVYEQFLP 105
           LPGR NI+LS    S    D+ +    S++ A+A   +    V +I VIGG  +Y + + 
Sbjct: 75  LPGRLNIVLSRSYVSHGSNDEDIILTNSIENALAKVEEYSKPVEKIFVIGGSELYNKLIS 134

Query: 106 --KAQKLYLTHIDAE--VEGDT--HFPDY-EPDDW 133
             K Q L +T I +   VE DT   FP Y E  DW
Sbjct: 135 HEKVQHLLITEIKSTRPVEVDTWLKFPIYTESSDW 169


>UniRef50_A8SNM7 Putative uncharacterized protein n=1 Tax=Parvimonas micra ATCC
           33270 RepID=A8SNM7_9FIRM
          Length = 166

 Score = 79.3 bits (194), Expect = 3e-14,   Method: Compositional matrix adjust.
 Identities = 42/138 (30%), Positives = 73/138 (52%), Gaps = 5/138 (3%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIIL 62
           ++A       IG +N + + L  D+ +FK  T +  +I GR T+E    +PLP RKNI+L
Sbjct: 9   IVAITEKTNAIGKDNNLLYFLKEDMNFFKEKTCDNSIICGRKTFEGFKIKPLPKRKNIVL 68

Query: 63  SSQPGTDDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHIDAE-- 118
           +    + + V   K++++ I    + P  +  V GG  +YEQ +    ++Y+T  + +  
Sbjct: 69  TKSDFSFEGVRRFKNIEDLINFVKENPKEKFFVCGGMSIYEQLIDFCSRMYITKYEEKEA 128

Query: 119 VEGDTHFPDYEPDDWESV 136
           VE D+HFP  +   W+ V
Sbjct: 129 VEADSHFPKIDEKVWKVV 146


>UniRef50_A5WHY1 Dihydrofolate reductase n=4 Tax=Moraxellaceae RepID=A5WHY1_PSYWF
          Length = 193

 Score = 79.3 bits (194), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 59/180 (32%), Positives = 93/180 (51%), Gaps = 30/180 (16%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT-----------LNKPVIMGRHTWESI 50
           ++ I A++ +R IG  N +PW++P DL  FK  T           L   VIMGR T+ES+
Sbjct: 8   VAQIVAISRNRCIGKGNDLPWHIPNDLKHFKAMTTAETDAYVDTGLKGIVIMGRKTFESM 67

Query: 51  G-RPLPGRKNIILSSQ---------PGTDDRVTWVKSVDEAIAACGDVPE------IMVI 94
           G +PLP R N I+++Q          G  D V  V ++D+A+    +V        I VI
Sbjct: 68  GSKPLPKRVNFIVTTQMDYAQQKGLEGLKD-VHVVHNLDDALTHAANVAHGLKFETIWVI 126

Query: 95  GGGRVYEQFLPKAQKLYLTHIDAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCF 153
           GG RV+++ +    ++ LT +D ++E GD  +P+  P+D+E         D ++  SY F
Sbjct: 127 GGERVFKRAMMFTDRIELTVVDTDIEDGDAFYPEI-PEDFELTQESESFTDEKSGLSYKF 185


>UniRef50_UPI000186EC32 Dihydrofolate reductase, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186EC32
          Length = 190

 Score = 79.3 bits (194), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 57/181 (31%), Positives = 82/181 (45%), Gaps = 28/181 (15%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51
            +LIAA+  +  IG +  +PWNL  +L +F R T +         VIMGR TW+S+    
Sbjct: 5   FNLIAAVCSNNGIGYKGNLPWNLRKELQYFNRMTKDVKNPEKKNAVIMGRKTWDSLPHNW 64

Query: 52  RPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLP 105
           +PLPGR N +L++Q    D       +++ I           +    VIGG +VYE  L 
Sbjct: 65  KPLPGRYNFVLTTQSLNLDGAVVCSDLNDLIKKINSPDYSNLIETAWVIGGSKVYESVLK 124

Query: 106 K--AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHD------ADAQNSHSYCFEILE 157
                + YLT I  E E D  F +Y   D+   F E  D         +N   Y F + E
Sbjct: 125 YGLCHRFYLTRIKKEFECDCFF-NY---DFTKDFKEVSDDRVPKGVQKENEIEYVFHVYE 180

Query: 158 R 158
           +
Sbjct: 181 K 181


>UniRef50_Q4JX60 FolA protein n=3 Tax=Corynebacterium RepID=Q4JX60_CORJK
          Length = 234

 Score = 79.3 bits (194), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 56/161 (34%), Positives = 74/161 (45%), Gaps = 25/161 (15%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           I +I A   D VIG    MPW LP DL  FK  T   PV+MGR +WE++    RPLP R 
Sbjct: 42  IGMIWAQTTDGVIGDGADMPWYLPEDLKHFKNATSGYPVVMGRTSWEALDDGFRPLPDRT 101

Query: 59  NIILSSQPGTDDRVTWVK--------------------SVDEAIAACGDVPEIMVIGGGR 98
           N +++ Q   D     V+                    S D+   A    P + V+GGG+
Sbjct: 102 NYVITRQDNYDAPGGIVEPSIPSALANAAEQILNELTDSADKGEGADDRTPTVWVLGGGQ 161

Query: 99  VYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSE 139
           VY Q +P A ++ +T ID  +E    F  Y P   E  F E
Sbjct: 162 VYAQCMPVADRIVITEID--MEAPERFQVYAPLVPEEEFEE 200


>UniRef50_C3JYD2 Putative dihydrofolate reductase n=1 Tax=Pseudomonas fluorescens
           SBW25 RepID=C3JYD2_PSEFS
          Length = 165

 Score = 79.3 bits (194), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 46/126 (36%), Positives = 70/126 (55%), Gaps = 7/126 (5%)

Query: 11  DRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNIILSSQP 66
           +R IG    +   +P D+  F   T+ KPVIMGR T+ES+    GRPL  R NI+LS  P
Sbjct: 8   NRSIGKAGGLLRMVPDDMRRFAAKTIGKPVIMGRKTFESVIALSGRPLADRPNIVLSRNP 67

Query: 67  GTD-DRVTWVKSVDEAIAACGDV-PEIMVIGGG-RVYEQFLPKAQKLYLTHIDAEVEGDT 123
             + ++    +S+  A+       PE + IGGG  +Y+Q + +  +LYLT  + + EG+ 
Sbjct: 68  AFEHEQAVVCRSLASALECAASYHPEEIHIGGGPELYDQVIDRVDRLYLTLFNDDHEGEA 127

Query: 124 HFPDYE 129
            FP +E
Sbjct: 128 RFPSFE 133


>UniRef50_D0WS26 Dihydrofolate reductase n=1 Tax=Actinomyces sp. oral taxon 848 str.
           F0332 RepID=D0WS26_9ACTO
          Length = 184

 Score = 79.0 bits (193), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 56/138 (40%), Positives = 75/138 (54%), Gaps = 4/138 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           ++  I A   +R IG + A+PW LP DLA F+R T   PVIMGR TWES+    RPLPGR
Sbjct: 2   ILGAIWAQGRERAIGKDGALPWRLPEDLALFRRVTSGHPVIMGRKTWESLPPRFRPLPGR 61

Query: 58  KNIILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +NI+LS  P    D    V+S+ EA  A     +  +IGG  +Y + +  A  L +T +D
Sbjct: 62  RNIVLSRDPSFAADGAEAVRSLAEAAEAASHCEQAWIIGGAALYAEAVNVADVLVVTDVD 121

Query: 117 AEVEGDTHFPDYEPDDWE 134
            +VEG   F       W 
Sbjct: 122 VDVEGADAFAPSIGGSWR 139


>UniRef50_B9YC91 Putative uncharacterized protein n=1 Tax=Holdemania filiformis DSM
           12042 RepID=B9YC91_9FIRM
          Length = 157

 Score = 79.0 bits (193), Expect = 5e-14,   Method: Compositional matrix adjust.
 Identities = 52/135 (38%), Positives = 78/135 (57%), Gaps = 4/135 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAAL     +G    MPW+ PADL  F+  T+ KP++MGR T E + R L GR+ II
Sbjct: 3   ITMIAALDEVGGLGKAGRMPWHCPADLRQFQAYTMGKPLLMGRKTAEPLRRRLLGRQLII 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVP---EIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
             S+   D     V++V+EA+A     P   E+++ GGG +Y  +LP A  L ++ I   
Sbjct: 63  -QSRTMKDPDFPVVRTVNEALAWMAARPEFDELVIGGGGEIYALWLPYAAHLRISRIAGR 121

Query: 119 VEGDTHFPDYEPDDW 133
            + DT FP ++P +W
Sbjct: 122 FDCDTFFPKWDPQEW 136


>UniRef50_C7XU42 Dihydrofolate reductase n=1 Tax=Lactobacillus coleohominis
           101-4-CHN RepID=C7XU42_9LACO
          Length = 166

 Score = 78.6 bits (192), Expect = 6e-14,   Method: Compositional matrix adjust.
 Identities = 41/125 (32%), Positives = 64/125 (51%), Gaps = 4/125 (3%)

Query: 14  IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVT 73
           IG    +PW+LP DL  FK  T + P++MG  T+ SIGRPLP R NI++S  P   D+V 
Sbjct: 15  IGKNGQLPWHLPVDLKHFKTVTDHHPIVMGARTFASIGRPLPNRPNIVVSHHPVAVDQVI 74

Query: 74  WVKSVDEAIAAC----GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYE 129
            V ++++ +        D  E+ +IGG  ++ Q +     L+ T +     GD      +
Sbjct: 75  TVTNIEDLMNLIFKRYADQEEVCIIGGAGLFAQMVAHVNCLHRTIVMGNHHGDVKMIPID 134

Query: 130 PDDWE 134
              W+
Sbjct: 135 YHQWQ 139


>UniRef50_Q96V60 Dihydrofolate reductase (Fragment) n=2 Tax=Pneumocystis carinii
           RepID=Q96V60_PNECA
          Length = 176

 Score = 78.6 bits (192), Expect = 7e-14,   Method: Compositional matrix adjust.
 Identities = 53/149 (35%), Positives = 78/149 (52%), Gaps = 26/149 (17%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKP----------VIMGRHTWESI--- 50
           LI AL V   IG  NA+PW L +D+A+FKR T + P          V+MGR TWES+   
Sbjct: 1   LIVALTVSCGIGKGNALPWRLKSDMAYFKRVTSDVPVSDSTKWMNVVLMGRKTWESLPER 60

Query: 51  GRPLPGRKNIILSSQPGTD--DRVTWVKSVDEAI---------AACGDVPEIMVIGGGRV 99
            RPL GR N+++S Q   D        KS+++A+         ++   V  I VIGG ++
Sbjct: 61  FRPLKGRINVVISRQEVLDLGQGTYHAKSLNDALVLLSCIYDTSSSIQVNRIFVIGGAQL 120

Query: 100 YEQFL--PKAQKLYLTHIDAEVEGDTHFP 126
           Y+  +  P+  ++  T I  E++ D  FP
Sbjct: 121 YKAAMEHPRLDRIMATVIHKEIDCDVFFP 149


>UniRef50_C4G1L6 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC
           49176 RepID=C4G1L6_ABIDE
          Length = 165

 Score = 78.2 bits (191), Expect = 8e-14,   Method: Compositional matrix adjust.
 Identities = 53/156 (33%), Positives = 81/156 (51%), Gaps = 13/156 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           I LIAA+ +   IG + ++ + +P DL  FK+ T    V+MGR T+ESIG  PL  R NI
Sbjct: 3   IKLIAAVDLRFGIGKDGSLLFKIPEDLRLFKQLTTGNIVLMGRKTFESIGCIPLTDRINI 62

Query: 61  ILSSQPGTDDR-VTWVKSVDEAIAACGDV---PEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++SS    ++  V    +   AI  C  +    ++ +IGGG++YEQ +  A ++ LT  +
Sbjct: 63  VISSAKKYENEDVINFDNYKTAIEYCKQIFSDKDLYIIGGGKIYEQGIKYADEIILTKYN 122

Query: 117 AEVEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSY 151
              E  DT+FP         +   F +AD     SY
Sbjct: 123 KVYEDVDTYFP-------VDIMDNFSEADVIMEGSY 151


>UniRef50_Q6A328 Dihydrofolate reductase n=1 Tax=Pasteurella multocida
           RepID=Q6A328_PASMU
          Length = 169

 Score = 78.2 bits (191), Expect = 9e-14,   Method: Compositional matrix adjust.
 Identities = 51/161 (31%), Positives = 77/161 (47%), Gaps = 10/161 (6%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI---GRPLPGRKN 59
           SLI A+   R +G +N + W+LP D+ +FK  T    V+MGR +WESI    RPLP R N
Sbjct: 6   SLIVAIGKHREMGADNDLLWHLPRDMQFFKETTTGHAVVMGRKSWESIPQKYRPLPNRLN 65

Query: 60  IILSSQPG-TDDRVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLPKA--QKLYLTHI 115
            +L+     + +  T +  + E      G      +IGG ++Y+  L      ++Y+T +
Sbjct: 66  FVLTRDKNYSAEGATVIYDLKEVAQHLEGKNLTCFIIGGAQIYQLALETGLLNEMYVTQV 125

Query: 116 DAEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEI 155
                E DT FP     +WE    +  + D    H Y F I
Sbjct: 126 HNTFEEADTFFPFVNWGEWEE--EDILEQDKDEKHLYSFNI 164


>UniRef50_Q937I9 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q937I9_ECOLX
          Length = 189

 Score = 77.8 bits (190), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 46/142 (32%), Positives = 83/142 (58%), Gaps = 5/142 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI+A + + VIG    +PW+   +   FK  T N+ +++GR T++S+G  LP RK  +
Sbjct: 3   ISLISATSENGVIGNGPDLPWSAKGEQLLFKALTYNQWLLVGRKTFDSMG-VLPNRKYAV 61

Query: 62  LSSQ--PGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +S +    +++ V    S++ A+     + + + V GGG++Y   + KA  ++L+ +  E
Sbjct: 62  VSRKGISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHVE 121

Query: 119 VEGDTHFPDYEPDDWESVFSEF 140
           VEGD +FP   P+++  VF +F
Sbjct: 122 VEGDINFPKI-PENFNLVFEQF 142


>UniRef50_Q0FG98 Dihydrofolate reductase n=1 Tax=Rhodobacterales bacterium HTCC2255
           RepID=Q0FG98_9RHOB
          Length = 159

 Score = 77.8 bits (190), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 44/132 (33%), Positives = 72/132 (54%), Gaps = 6/132 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPW-NLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRK 58
           MI  I A   +  IG    +PW + PADL WFK NTLN  ++MG+ TW+S+ R PLP R+
Sbjct: 1   MIKAILACDDEWGIGKNGDLPWPHNPADLRWFKNNTLNSVIVMGKSTWDSLPRKPLPNRE 60

Query: 59  NIILSSQP---GTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           N+I+++     G DD        ++  +++  D+  I +IGG ++    +   ++ +L+ 
Sbjct: 61  NLIVTTSKQEFGYDDYEFINFSDLEVKLSSTKDINNIWIIGGAKLISGLINFIEEFHLSR 120

Query: 115 IDAEVEGDTHFP 126
           I+     DT  P
Sbjct: 121 INGNFNCDTFLP 132


>UniRef50_P27422 Dihydrofolate reductase type 7 n=46 Tax=Bacteria RepID=DYR7_ECOLX
          Length = 157

 Score = 77.4 bits (189), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 48/160 (30%), Positives = 92/160 (57%), Gaps = 9/160 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI+A + + VIG    +PW+   +   FK  T N+ +++GR T++S+G  LP RK  +
Sbjct: 3   ISLISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMG-VLPNRKYAV 61

Query: 62  LSSQ--PGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +S +    +++ V    S++ A+     + + + V GGG++Y   + KA  ++L+ +  E
Sbjct: 62  VSRKGISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHVE 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           VEGD +FP   P+++  VF +F  ++     +Y ++I ++
Sbjct: 122 VEGDINFPKI-PENFNLVFEQFFLSNI----NYTYQIWKK 156


>UniRef50_B0MRL8 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM
           15702 RepID=B0MRL8_9FIRM
          Length = 161

 Score = 77.4 bits (189), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 48/138 (34%), Positives = 73/138 (52%), Gaps = 5/138 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60
           + +I A+  +  IG +  +  +L  DL   K  T+   ++MG  T+ S   RPLP R+N+
Sbjct: 1   MEIIVAVDENYGIGKDGDLLAHLSPDLKRLKAMTVGNIIVMGSKTYMSFPKRPLPDRENL 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           I++  P     +     VDE +  +   D P I V+GGG VYEQ LP  +K ++T I   
Sbjct: 61  IITHHPENYPGIKCFTGVDEFLEYSKTADKP-IFVLGGGSVYEQLLPYCEKAHITKILHS 119

Query: 119 VEGDTHFPDYEPD-DWES 135
            E DT FP+ + + DWE 
Sbjct: 120 FEADTFFPNLDNNPDWEK 137


>UniRef50_P16184 Dihydrofolate reductase n=38 Tax=Pneumocystis RepID=DYR_PNECA
          Length = 206

 Score = 77.4 bits (189), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 52/173 (30%), Positives = 86/173 (49%), Gaps = 27/173 (15%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKP----------VIMGRHTWESI- 50
           ++LI AL     IG  N++PW L  ++++FKR T   P          V+MGR TWESI 
Sbjct: 7   LTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIP 66

Query: 51  --GRPLPGRKNIILSSQPGTD--DRVTWVKSVDEAI---------AACGDVPEIMVIGGG 97
              RPL GR N++++     D  + +   KS+D A+          +   +  I VIGG 
Sbjct: 67  LQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGA 126

Query: 98  RVYEQFL--PKAQKLYLTHIDAEVEGDTHFP-DYEPDDWESVFSEFHDADAQN 147
           ++Y+  +  PK  ++  T I  ++  D  FP  +   +W SV+ +   +D ++
Sbjct: 127 QLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLES 179


>UniRef50_C4Z7Z2 Dihydrofolate reductase n=34 Tax=Bacteria RepID=C4Z7Z2_EUBR3
          Length = 163

 Score = 76.6 bits (187), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 46/139 (33%), Positives = 75/139 (53%), Gaps = 6/139 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI--GRPLPGRKN 59
           ++LIAA+  +  IG  N +   +P D  +F+  T  K V+MGR T ES    RPL  R N
Sbjct: 1   MNLIAAVDNNWAIGKNNQLLVRIPMDQKFFREMTTGKVVVMGRKTLESFPNSRPLKNRTN 60

Query: 60  IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+L+  P  + +    V S+DE        +  +I +IGG ++YEQ + +    ++T +D
Sbjct: 61  IVLTHNPSYEVEGAVVVHSLDELHKELEKYNSEDIYIIGGQKIYEQLVDECDVAHITKVD 120

Query: 117 AEVEGDTHFPDY-EPDDWE 134
            E + D +FP+  E  +W+
Sbjct: 121 FEYDADAYFPNLDEKPEWQ 139


>UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraurelia
           RepID=DRTS_PARTE
          Length = 462

 Score = 76.6 bits (187), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 45/153 (29%), Positives = 79/153 (51%), Gaps = 11/153 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
            S++ A+ ++  IG +N +PW L  DL  FK+ T    VIMGR T+ES+  +PLP R N+
Sbjct: 7   FSMVLAMTLNGGIGYQNRLPWKLKEDLQRFKKITTGGIVIMGRKTFESMNSKPLPNRVNV 66

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLP--KAQKLYLTHIDA 117
           ++S    + + V     +++A+        ++ +IGG R++E+ L   K   ++LT I  
Sbjct: 67  VISKNMKSSNEVQVFPRIEDALQFYNTSHQKLYLIGGKRIFEEGLATDKCSDVHLTRIGV 126

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHS 150
           E + D +         +++FS F       + S
Sbjct: 127 ETKCDVYLN-------KNIFSTFQVNKTSQTKS 152


>UniRef50_C2KQT3 Possible dihydrofolate reductase n=2 Tax=Mobiluncus mulieris
           RepID=C2KQT3_9ACTO
          Length = 227

 Score = 75.9 bits (185), Expect = 4e-13,   Method: Compositional matrix adjust.
 Identities = 48/146 (32%), Positives = 75/146 (51%), Gaps = 13/146 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + +I A     VIG    M W +P DL +FK  T+  PVIMG  +++++G PL GR+NII
Sbjct: 55  LGVIWAEDCHHVIGAGGGMVWRVPDDLRFFKETTMGCPVIMGTGSFKALGEPLKGRRNII 114

Query: 62  LSSQPGT------DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPK--AQKLYLT 113
           L+  P        +  +    ++D+AI  C    E+ + GGG VY++ +    A  L ++
Sbjct: 115 LTRHPSALADFTREGLIETASNLDDAIKLCAGTKEVWITGGGVVYQEVMDAGIADLLVVS 174

Query: 114 HID--AEVEGD---THFPDYEPDDWE 134
            +D  A V  D   T  P  +P  W+
Sbjct: 175 QLDLIAPVPPDAKVTVAPVIDPQRWQ 200


>UniRef50_C4LHD2 Bifunctional dihydrofolate reductase-thymidylate synthase n=1
           Tax=Corynebacterium kroppenstedtii DSM 44385
           RepID=C4LHD2_CORK4
          Length = 221

 Score = 75.5 bits (184), Expect = 6e-13,   Method: Compositional matrix adjust.
 Identities = 59/140 (42%), Positives = 72/140 (51%), Gaps = 24/140 (17%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR---PLPGR 57
           +I +I A   D VIG    MPW++P D+A FK+ T   PVIMG  TW SI     PLPGR
Sbjct: 31  LIGVIWASDRDGVIGDGTRMPWHVPEDMAHFKQLTWGVPVIMGSATWSSIPSRFTPLPGR 90

Query: 58  KNIILS---SQPGTDDRVTWVKSVDEAIAACGDVP-------------EIMVIGGGRVYE 101
            NI+LS   S   T D V    S+D   AA  D+P             +  VIGGG VY 
Sbjct: 91  TNIVLSRRWSDEDTPDGVILHHSLD---AAFKDIPHPVFTRRVAPENVDAWVIGGGEVYR 147

Query: 102 QFL--PKAQKLYLTHIDAEV 119
           + L  P+ +   LT IDA V
Sbjct: 148 EALTRPEVRLAVLTEIDAAV 167


>UniRef50_P0ABQ7 Dihydrofolate reductase type 8 n=2 Tax=Enterobacteriaceae
           RepID=DYR8_ECOLX
          Length = 169

 Score = 75.1 bits (183), Expect = 7e-13,   Method: Compositional matrix adjust.
 Identities = 58/157 (36%), Positives = 82/157 (52%), Gaps = 17/157 (10%)

Query: 1   MISLIAALAV--DRVIGMENAMPWN-LPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGR 57
           MI L A LA   +  IG +NA+PW  L  DLA FK+ T+ K VIMGR T+ES+   L GR
Sbjct: 1   MIELHAILAATANGCIGKDNALPWPPLKGDLARFKKLTMGKVVIMGRKTYESLPVKLEGR 60

Query: 58  KNIILSSQ----PGTDDR--VTWVKSVDEAI-----AACGDVPEIMVIGGGRVYEQFLPK 106
             I+++ Q    PG  D     +V +V +A+      + GDV    VIGG  ++++    
Sbjct: 61  TCIVMTRQALELPGVRDANGAIFVNNVSDAMRFAQEESVGDVA--YVIGGAEIFKRLALM 118

Query: 107 AQKLYLTHIDAEVEGDTHFPDYE-PDDWESVFSEFHD 142
             ++ LT +    EGDT+    E   D+E    E HD
Sbjct: 119 ITQIELTFVKRLYEGDTYVDLAEMVKDYEQNGMEEHD 155


>UniRef50_Q8SDF8 PHIKZ004 n=1 Tax=Pseudomonas phage phiKZ RepID=Q8SDF8_9CAUD
          Length = 173

 Score = 74.7 bits (182), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 48/156 (30%), Positives = 85/156 (54%), Gaps = 20/156 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           I LI A  ++ VIG  N +PW++P DLA+FK  T    VIMG++T+ S+G +PLP R NI
Sbjct: 3   IKLIVAHDLNGVIGYNNLLPWHIPEDLAFFKEMTTGCCVIMGKNTFLSLGSKPLPNRNNI 62

Query: 61  ILSSQ--------PGTDDRVTWVKSVDEAIAACGDV-----PEIMVIGGGRVYEQFLPK- 106
           ++SS            D+++  + ++  AI            ++ +IGG ++Y++ + K 
Sbjct: 63  VVSSSLYRNGNYPVAYDNKLGVLPNLSAAIVYATHFNKETGKDVWIIGGSQLYKEVIEKD 122

Query: 107 -AQKLYLTHIDAEVEGDT--HFPD--YEPDDWESVF 137
              ++Y+T +  E++  +  +FP    + D W+S  
Sbjct: 123 ILDEMYITTVKMEIDNSSCVYFPKEIIKWDKWKSTI 158


>UniRef50_B6AE97 Thymidylate synthase family protein n=4 Tax=cellular organisms
           RepID=B6AE97_9CRYT
          Length = 549

 Score = 74.3 bits (181), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 49/156 (31%), Positives = 82/156 (52%), Gaps = 29/156 (18%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-----------------KPVIMG 43
           +I ++AA   ++ IG  N +PW++  DL +F+  T +                   +I+G
Sbjct: 22  VIIIVAASTKEKGIGKGNNLPWSIKEDLKFFREITCSTIEQSQDDKENTKIEKVNAIILG 81

Query: 44  RHTWESIGR-PLPGRKNIILS-----SQPGTDDRVTWVKSVDEAIAACGD---VPEIMVI 94
           R TW+S+ R PL  RK I+LS          D  V+ VKS+DEAI  C +   + +I++ 
Sbjct: 82  RKTWDSMKRIPLKNRKVIVLSRTLQRCDNKNDSGVSIVKSLDEAINLCNNDISIHKIVIC 141

Query: 95  GGGRVYEQFLPK--AQKLYLTHID-AEVEGDTHFPD 127
           GG  +Y + + K   + +YLT +  ++ E DT+FP+
Sbjct: 142 GGESIYRECIEKNIVETIYLTRVSTSKKEFDTYFPN 177


>UniRef50_A7SCT0 Predicted protein n=2 Tax=Nematostella vectensis RepID=A7SCT0_NEMVE
          Length = 187

 Score = 74.3 bits (181), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 23/156 (14%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT-------LNKPVIMGRHTWESIG--- 51
            S I A+ + R IG  N +PW +  D+ +F   T           VIMGR  WESI    
Sbjct: 8   FSCIVAMDLKRGIGKNNDLPWKIKGDMKFFTEKTSEVKTEGKQNAVIMGRKVWESIPEKF 67

Query: 52  RPLPGRKNIILS---SQPGTDDRVTWVKSVDEAIAACGDVP------EIMVIGGGRVYEQ 102
           RPL GR NI+LS   S+P    ++   +S ++A+      P       + V GG  +Y+ 
Sbjct: 68  RPLKGRLNIVLSRTLSEPPQGAQL--CRSFEQALTILSTDPYTKKIENVFVCGGSALYKD 125

Query: 103 FLPKA--QKLYLTHIDAEVEGDTHFPDYEPDDWESV 136
            +  +   ++Y+T+ID E + D  FP+++ + +  V
Sbjct: 126 AMAHSACTRIYITYIDQEFDCDVFFPEFDQNTYHLV 161


>UniRef50_Q5V3R2 Dihydrofolate reductase 1 n=1 Tax=Haloarcula marismortui
           RepID=DYR1_HALMA
          Length = 185

 Score = 74.3 bits (181), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 50/170 (29%), Positives = 78/170 (45%), Gaps = 38/170 (22%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + L+ A   + VIG++  +PW+ P D+  +K      P+I+GR T+ES+ +P+P    ++
Sbjct: 9   LVLVVAADENNVIGLDGGVPWHYPEDVRQYKNRIAGHPIILGRRTFESM-KPIPDCYTVV 67

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEI----------------------------MV 93
           L+S    DDR    +S D         P+I                             V
Sbjct: 68  LTS----DDR----RSADSETVEYATTPQIAVEAAARAGASGAFAGDSAGADSSPPVTYV 119

Query: 94  IGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDA 143
           IGG  VY+ FLP A +++L+ I    EGD +FPD    +W  +  E HD 
Sbjct: 120 IGGEAVYDLFLPFAGRVFLSRIHEHNEGDRYFPDLGA-EWTELSREPHDG 168


>UniRef50_A3DES9 Dihydrofolate reductase n=5 Tax=Clostridium RepID=A3DES9_CLOTH
          Length = 167

 Score = 73.6 bits (179), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 52/149 (34%), Positives = 77/149 (51%), Gaps = 12/149 (8%)

Query: 6   AALAVDRV--IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI--GRPLPGRKNII 61
           A +AVD    IG +  +   +P D+ +F++ TLNK V+MGR T+ES+    PL  R NII
Sbjct: 3   AIVAVDSNWGIGYKGNLLQRIPEDMRFFRQMTLNKVVVMGRKTFESLPGKEPLKDRVNII 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LS     + D +   +SVD         +  +I VIGG  VY Q LP   + ++T  +  
Sbjct: 63  LSKSENIEKDGIIICRSVDGLFLELKKYNSDDIFVIGGEEVYTQLLPYCSEAHVTKFNGA 122

Query: 119 VEGDTHFPDY-EPDDWESVF----SEFHD 142
              D +FP+  E + W+ V      EF+D
Sbjct: 123 YSADRYFPNLDEMEGWKLVCVGEPKEFND 151


>UniRef50_C0VSW2 Dihydrofolate reductase n=2 Tax=Corynebacterium glucuronolyticum
           RepID=C0VSW2_9CORY
          Length = 167

 Score = 73.6 bits (179), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 41/110 (37%), Positives = 62/110 (56%), Gaps = 6/110 (5%)

Query: 5   IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIILS 63
           I A + D +IG  + MPW LP DL  FK  T+ + ++MGR TWESIG + LPGR N++LS
Sbjct: 4   IWAQSRDGIIGDGSTMPWYLPEDLHHFKNTTMGEDILMGRKTWESIGSKALPGRTNLVLS 63

Query: 64  SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           ++   D    W        +   D  +  +IGGG +Y+   P+  ++ +T
Sbjct: 64  TREPGD----WSAGATVVSSVPADF-DGWLIGGGSLYQSLYPRLSRIAVT 108


>UniRef50_Q6F181 Dihydrofolate reductase n=1 Tax=Mesoplasma florum
           RepID=Q6F181_MESFL
          Length = 161

 Score = 73.2 bits (178), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 38/144 (26%), Positives = 75/144 (52%), Gaps = 8/144 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MI +I A     VIG +N++PW++  ++  F+  TLN+ V+MG  T+ES+  + LP R N
Sbjct: 1   MIKMIWAQTEKGVIGKDNSLPWSIKEEMQHFRTTTLNQNVLMGGKTFESMNFKGLPNRIN 60

Query: 60  IILSS-----QPGTDDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYL 112
            +L+      +    + V ++   D  +         ++ +IGG ++YE F     ++  
Sbjct: 61  YVLTRDTEKYKEHMSENVNFINKKDFILKEFKGNTSKDVYIIGGSQIYELFFDDCDEIIR 120

Query: 113 THIDAEVEGDTHFPDYEPDDWESV 136
           + I  + EG+ H  ++  D+++ +
Sbjct: 121 SMIKDDFEGNVHIKNFNYDNFDKI 144


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_P0ABQ5 Dihydrofolate reductase n=111 Tax=Enterobacteria...   269   2e-71
UniRef50_P27498 Dihydrofolate reductase n=89 Tax=Gammaproteobact...   261   5e-69
UniRef50_P11045 Dihydrofolate reductase n=23 Tax=Firmicutes RepI...   250   1e-65
UniRef50_A7Z5T2 DfrA n=2 Tax=Bacillaceae RepID=A7Z5T2_BACA2           242   2e-63
UniRef50_P12833 Dihydrofolate reductase type 3 n=26 Tax=Proteoba...   242   3e-63
UniRef50_D0U4K0 Dihydrofolate reductase n=2 Tax=uncultured SUP05...   239   2e-62
UniRef50_B0MUX5 Putative uncharacterized protein n=1 Tax=Alistip...   239   2e-62
UniRef50_Q65IB5 DfrA n=4 Tax=Bacillaceae RepID=Q65IB5_BACLD           237   1e-61
UniRef50_Q1LK80 Dihydrofolate reductase n=3 Tax=Proteobacteria R...   236   2e-61
UniRef50_A1U3D7 Dihydrofolate reductase n=6 Tax=Gammaproteobacte...   235   4e-61
UniRef50_D2QJY0 Dihydrofolate reductase n=2 Tax=Bacteria RepID=D...   234   5e-61
UniRef50_D0KZ69 Dihydrofolate reductase n=2 Tax=Gammaproteobacte...   234   8e-61
UniRef50_A4Y040 Dihydrofolate reductase n=28 Tax=Proteobacteria ...   231   6e-60
UniRef50_Q3JEI1 Dihydrofolate reductase n=3 Tax=Gammaproteobacte...   230   1e-59
UniRef50_A9KH09 Dihydrofolate reductase n=8 Tax=Coxiella burneti...   230   1e-59
UniRef50_Q31I54 Dihydrofolate reductase n=32 Tax=Bacteria RepID=...   229   2e-59
UniRef50_P43791 Dihydrofolate reductase n=19 Tax=Gammaproteobact...   229   2e-59
UniRef50_A9I779 FolA protein n=2 Tax=Bordetella RepID=A9I779_BORPD    229   2e-59
UniRef50_Q5R038 Dihydrofolate reductase n=3 Tax=Alteromonadales ...   229   2e-59
UniRef50_C2FZ23 Dihydrofolate reductase n=2 Tax=Sphingobacterium...   227   1e-58
UniRef50_Q0VM07 Dihydrofolate reductase n=5 Tax=Gammaproteobacte...   227   1e-58
UniRef50_Q2Y7L3 Dihydrofolate reductase n=7 Tax=Betaproteobacter...   226   2e-58
UniRef50_A5FJX2 Dihydrofolate reductase n=1 Tax=Flavobacterium j...   224   8e-58
UniRef50_C7PKU6 Dihydrofolate reductase n=1 Tax=Chitinophaga pin...   223   2e-57
UniRef50_A0AJX9 DfrA protein n=15 Tax=Listeria RepID=A0AJX9_LISW6     223   2e-57
UniRef50_Q2SXY8 Dihydrofolate reductase n=18 Tax=Proteobacteria ...   222   3e-57
UniRef50_C6P459 Dihydrofolate reductase n=1 Tax=Sideroxydans lit...   221   5e-57
UniRef50_UPI0001787F40 Dihydrofolate reductase n=1 Tax=Geobacill...   221   5e-57
UniRef50_Q15PF1 Dihydrofolate reductase n=18 Tax=Gammaproteobact...   221   5e-57
UniRef50_C1XJD1 Dihydrofolate reductase n=1 Tax=Meiothermus rube...   221   8e-57
UniRef50_A1AXR7 Dihydrofolate reductase n=6 Tax=Proteobacteria R...   220   1e-56
UniRef50_A7HVX5 Dihydrofolate reductase n=13 Tax=Proteobacteria ...   219   2e-56
UniRef50_C6X2F4 Dihydrofolate reductase n=20 Tax=Bacteroidetes R...   219   2e-56
UniRef50_Q67JQ2 Dihydrofolate reductase n=1 Tax=Symbiobacterium ...   219   3e-56
UniRef50_A2SN57 Dihydrofolate reductase n=34 Tax=Burkholderiales...   219   4e-56
UniRef50_A5EUV9 Dihydrofolate reductase n=1 Tax=Dichelobacter no...   218   4e-56
UniRef50_C0YTZ2 Possible dihydrofolate reductase type I involved...   218   4e-56
UniRef50_Q3K556 Dihydrofolate reductase n=8 Tax=Bacteria RepID=Q...   217   6e-56
UniRef50_C7RLL7 Dihydrofolate reductase n=1 Tax=Candidatus Accum...   217   8e-56
UniRef50_B8KL97 Dihydrofolate reductase n=1 Tax=gamma proteobact...   217   8e-56
UniRef50_C6CYL9 Dihydrofolate reductase n=1 Tax=Paenibacillus sp...   217   1e-55
UniRef50_Q1QUE0 Dihydrofolate reductase n=12 Tax=Bacteria RepID=...   217   1e-55
UniRef50_C9RIZ1 Dihydrofolate reductase n=1 Tax=Fibrobacter succ...   217   1e-55
UniRef50_Q2K6G9 Dihydrofolate reductase protein n=3 Tax=Rhizobia...   216   2e-55
UniRef50_A5GBA2 Dihydrofolate reductase n=2 Tax=Geobacter RepID=...   216   2e-55
UniRef50_A4IUE2 Dihydrofolate reductase n=1 Tax=Yersinia ruckeri...   216   2e-55
UniRef50_UPI0001698640 dihydrofolate reductase n=1 Tax=Endorifti...   215   3e-55
UniRef50_A2U3M8 Dihydrofolate reductase n=2 Tax=Polaribacter Rep...   215   4e-55
UniRef50_A1VQZ7 Dihydrofolate reductase n=9 Tax=Bacteria RepID=A...   214   5e-55
UniRef50_Q1CZU3 Dihydrofolate reductase n=1 Tax=Myxococcus xanth...   214   6e-55
UniRef50_A6UB22 Dihydrofolate reductase n=18 Tax=Alphaproteobact...   214   7e-55
UniRef50_UPI0000E87D66 dihydrofolate reductase n=1 Tax=Methyloph...   214   8e-55
UniRef50_C9BJS9 Dihydrofolate reductase n=13 Tax=Enterococcus Re...   214   8e-55
UniRef50_A5CVJ7 Dihydrofolate reductase n=1 Tax=Candidatus Vesic...   214   9e-55
UniRef50_Q21NW4 Dihydrofolate reductase n=3 Tax=Bacteria RepID=Q...   214   9e-55
UniRef50_A3N0P3 Dihydrofolate reductase n=6 Tax=Pasteurellaceae ...   214   9e-55
UniRef50_Q5X875 Dihydrofolate reductase FolA n=6 Tax=Legionella ...   214   1e-54
UniRef50_D0J2N2 Dihydrofolate reductase region n=3 Tax=Bacteria ...   213   2e-54
UniRef50_Q5WDS2 Dihydrofolate reductase n=3 Tax=Bacillus RepID=Q...   212   2e-54
UniRef50_C5CTW3 Dihydrofolate reductase n=1 Tax=Variovorax parad...   212   3e-54
UniRef50_Q47IJ5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=Q...   212   3e-54
UniRef50_B3PTQ3 Dihydrofolate reductase protein n=49 Tax=Proteob...   212   4e-54
UniRef50_Q9RR65 Dihydrofolate reductase n=2 Tax=Deinococcus RepI...   211   5e-54
UniRef50_Q11US6 Dihydrofolate reductase n=1 Tax=Cytophaga hutchi...   211   6e-54
UniRef50_Q54277 Dihydrofolate reductase n=84 Tax=Bacilli RepID=D...   210   1e-53
UniRef50_P04174 Dihydrofolate reductase n=33 Tax=Neisseriaceae R...   210   1e-53
UniRef50_D2QWB5 Dihydrofolate reductase n=1 Tax=Pirellula staley...   210   1e-53
UniRef50_Q5P234 Dihydrofolate reductase n=14 Tax=cellular organi...   210   2e-53
UniRef50_C6XMY9 Dihydrofolate reductase n=1 Tax=Hirschia baltica...   209   2e-53
UniRef50_C3JBM5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=C...   209   2e-53
UniRef50_A3HTR7 Dihydrofolate reductase n=1 Tax=Algoriphagus sp....   209   2e-53
UniRef50_Q04F50 Dihydrofolate reductase n=2 Tax=Oenococcus oeni ...   208   4e-53
UniRef50_B8F4S8 Dihydrofolate reductase n=5 Tax=Pasteurellaceae ...   208   4e-53
UniRef50_C7X688 Dihydrofolate reductase n=7 Tax=Bacteroidales Re...   208   4e-53
UniRef50_B1XTJ0 Dihydrofolate reductase n=1 Tax=Polynucleobacter...   208   5e-53
UniRef50_D1BNV5 Dihydrofolate reductase region n=4 Tax=Veillonel...   207   1e-52
UniRef50_C4FSY3 Putative uncharacterized protein n=1 Tax=Catonel...   205   3e-52
UniRef50_B3ER85 Putative uncharacterized protein n=1 Tax=Candida...   205   3e-52
UniRef50_Q134B2 Dihydrofolate reductase n=10 Tax=Bradyrhizobiace...   205   3e-52
UniRef50_B2I6E9 Dihydrofolate reductase n=11 Tax=Xanthomonadacea...   205   4e-52
UniRef50_A1WMP6 Dihydrofolate reductase n=2 Tax=Proteobacteria R...   205   4e-52
UniRef50_D1QNC5 Dihydrofolate reductase n=1 Tax=Prevotella oris ...   205   5e-52
UniRef50_C6W5S3 Dihydrofolate reductase n=1 Tax=Dyadobacter ferm...   204   5e-52
UniRef50_C6W102 Dihydrofolate reductase n=1 Tax=Dyadobacter ferm...   204   6e-52
UniRef50_C0XLT5 Dihydrofolate reductase n=3 Tax=Lactobacillus Re...   204   6e-52
UniRef50_A6L1Q7 Dihydrofolate reductase n=34 Tax=Bacteroidales R...   204   1e-51
UniRef50_A4BS77 Dihydrofolate reductase n=1 Tax=Nitrococcus mobi...   203   1e-51
UniRef50_D0XKH5 Dihydrofolate reductase n=1 Tax=Brevundimonas su...   203   2e-51
UniRef50_B2SDZ8 Dihydrofolate reductase n=19 Tax=Francisella Rep...   202   2e-51
UniRef50_C1IBP0 Dihydrofolate reductase n=1 Tax=Clostridium sp. ...   202   2e-51
UniRef50_A1TM51 Dihydrofolate reductase n=4 Tax=cellular organis...   202   3e-51
UniRef50_C8X9J8 Dihydrofolate reductase n=1 Tax=Nakamurella mult...   202   3e-51
UniRef50_B2TR57 Dihydrofolate reductase n=10 Tax=Clostridium Rep...   201   6e-51
UniRef50_B6INW3 Dihydrofolate reductase n=4 Tax=Alphaproteobacte...   201   6e-51
UniRef50_Q0C500 Dihydrofolate reductase n=4 Tax=Alphaproteobacte...   200   1e-50
UniRef50_C4L1C8 Dihydrofolate reductase region n=2 Tax=Exiguobac...   199   2e-50
UniRef50_Q6MID1 FolA protein n=1 Tax=Bdellovibrio bacteriovorus ...   199   4e-50
UniRef50_Q5HPB1 Dihydrofolate reductase n=24 Tax=Bacilli RepID=D...   198   4e-50
UniRef50_A7IF75 Dihydrofolate reductase n=3 Tax=Rhizobiales RepI...   198   4e-50
UniRef50_Q1LSS4 Dihydrofolate reductase n=1 Tax=Baumannia cicade...   198   5e-50
UniRef50_UPI00017452A7 Dihydrofolate reductase n=1 Tax=Verrucomi...   197   7e-50
UniRef50_A8YUW1 Dihydrofolate reductase n=12 Tax=Lactobacillus R...   197   7e-50
UniRef50_Q2W7P5 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q...   197   7e-50
UniRef50_Q0AN20 Dihydrofolate reductase n=4 Tax=Alphaproteobacte...   197   1e-49
UniRef50_Q1WU16 Dihydrofolate reductase n=5 Tax=Lactobacillus Re...   195   3e-49
UniRef50_C8NE93 Dihydrofolate reductase n=24 Tax=Lactobacillales...   195   4e-49
UniRef50_Q03S94 Dihydrofolate reductase n=4 Tax=Lactobacillus Re...   195   4e-49
UniRef50_B9ECC1 Putative uncharacterized protein n=1 Tax=Macroco...   195   5e-49
UniRef50_Q3BX85 Dihydrofolate reductase n=6 Tax=Xanthomonas RepI...   195   5e-49
UniRef50_A0PY39 Dihydrofolate reductase n=3 Tax=Clostridium RepI...   194   6e-49
UniRef50_B6YRF0 Dihydrofolate reductase n=1 Tax=Candidatus Azoba...   194   6e-49
UniRef50_C1SJK6 Dihydrofolate reductase n=1 Tax=Denitrovibrio ac...   194   8e-49
UniRef50_A6GQA5 Dihydrofolate reductase n=1 Tax=Limnobacter sp. ...   194   1e-48
UniRef50_B9LR90 Dihydrofolate reductase region n=2 Tax=Halobacte...   194   1e-48
UniRef50_A0Z2N0 Dihydrofolate reductase n=2 Tax=unclassified Gam...   193   1e-48
UniRef50_Q03F97 Dihydrofolate reductase n=2 Tax=Pediococcus RepI...   193   2e-48
UniRef50_A4VUL2 Dihydrofolate reductase n=9 Tax=Streptococcus Re...   192   4e-48
UniRef50_UPI00016B2267 dihydrofolate reductase n=1 Tax=candidate...   192   4e-48
UniRef50_Q5HFZ7 Dihydrofolate reductase n=54 Tax=Staphylococcus ...   192   5e-48
UniRef50_UPI0001C37DF3 dihydrofolate reductase n=1 Tax=Ruminococ...   191   5e-48
UniRef50_Q5V600 Dihydrofolate reductase 2 n=1 Tax=Haloarcula mar...   191   6e-48
UniRef50_D1PCZ0 Dihydrofolate reductase n=1 Tax=Prevotella copri...   190   9e-48
UniRef50_Q38WX9 Dihydrofolate reductase n=5 Tax=Lactobacillales ...   190   1e-47
UniRef50_B5EIA1 Dihydrofolate reductase region n=5 Tax=Geobacter...   190   1e-47
UniRef50_C6XGC7 Dihydrofolate reductase protein n=1 Tax=Candidat...   190   1e-47
UniRef50_C9MLK6 Dihydrofolate reductase n=2 Tax=Prevotella RepID...   190   2e-47
UniRef50_C2MBL2 Dihydrofolate reductase n=1 Tax=Porphyromonas ue...   190   2e-47
UniRef50_B2ICT5 Dihydrofolate reductase n=2 Tax=Beijerinckiaceae...   189   2e-47
UniRef50_Q044A0 Dihydrofolate reductase n=13 Tax=Lactobacillus R...   189   2e-47
UniRef50_B6BUF2 Dihydrofolate reductase n=1 Tax=beta proteobacte...   189   2e-47
UniRef50_Q8D3H9 FolA protein n=1 Tax=Wigglesworthia glossinidia ...   189   3e-47
UniRef50_B9XJM4 Dihydrofolate reductase n=1 Tax=bacterium Ellin5...   189   4e-47
UniRef50_A1SJ32 Dihydrofolate reductase n=1 Tax=Nocardioides sp....   188   4e-47
UniRef50_C7NFY1 Dihydrofolate reductase n=3 Tax=Actinomycetales ...   188   7e-47
UniRef50_Q54801 Dihydrofolate reductase n=65 Tax=Streptococcus R...   187   8e-47
UniRef50_Q0SWS9 Dihydrofolate reductase n=1 Tax=Clostridium perf...   187   1e-46
UniRef50_C8WCM1 Dihydrofolate reductase region n=4 Tax=Zymomonas...   186   2e-46
UniRef50_D1PWR8 Dihydrofolate reductase n=1 Tax=Prevotella berge...   186   2e-46
UniRef50_Q5M5B2 Dihydrofolate reductase n=9 Tax=Streptococcus Re...   185   3e-46
UniRef50_B7H0P5 Dihydrofolate reductase type 3(Dihydrofolate red...   185   4e-46
UniRef50_C5NYS7 Dihydrofolate reductase n=1 Tax=Gemella haemolys...   185   5e-46
UniRef50_A5VJL0 Dihydrofolate reductase n=8 Tax=Lactobacillus Re...   184   9e-46
UniRef50_A0JZC8 Dihydrofolate reductase n=11 Tax=Bacteria RepID=...   184   9e-46
UniRef50_Q18HG9 Dihydrofolate reductase n=4 Tax=Halobacteriaceae...   184   1e-45
UniRef50_A6WGF8 Dihydrofolate reductase n=5 Tax=Actinomycetales ...   184   1e-45
UniRef50_Q7UIC9 Dihydrofolate reductase n=1 Tax=Rhodopirellula b...   184   1e-45
UniRef50_D2LGH8 Dihydrofolate reductase n=1 Tax=Rhodomicrobium v...   184   1e-45
UniRef50_Q494F1 Dihydrofolate reductase type I n=1 Tax=Candidatu...   183   2e-45
UniRef50_B2GC42 Dihydrofolate reductase n=4 Tax=Lactobacillus Re...   183   2e-45
UniRef50_B8HHJ9 Dihydrofolate reductase n=2 Tax=Micrococcineae R...   183   2e-45
UniRef50_C3RMT4 Dihydrofolate reductase n=4 Tax=Bacteria RepID=C...   182   3e-45
UniRef50_UPI00016BFCBD Dihydrofolate reductase n=1 Tax=Epulopisc...   182   3e-45
UniRef50_Q0TV23 Dihydrofolate reductase n=8 Tax=Clostridium perf...   182   3e-45
UniRef50_D0VXF2 Putative uncharacterized protein dfrP n=1 Tax=Ba...   182   4e-45
UniRef50_Q89AV2 Dihydrofolate reductase n=5 Tax=Buchnera aphidic...   182   5e-45
UniRef50_D0J8Z9 Dihydrofolate reductase n=2 Tax=Blattabacterium ...   181   5e-45
UniRef50_Q3F0Y0 Dihydrofolate reductase n=2 Tax=Bacillus thuring...   180   9e-45
UniRef50_Q6A328 Dihydrofolate reductase n=1 Tax=Pasteurella mult...   180   1e-44
UniRef50_B2UP70 Dihydrofolate reductase n=1 Tax=Akkermansia muci...   180   1e-44
UniRef50_B1MYC2 Dihydrofolate reductase n=3 Tax=Leuconostoc RepI...   180   1e-44
UniRef50_D1BYH5 Dihydrofolate reductase n=1 Tax=Xylanimonas cell...   180   1e-44
UniRef50_Q1GFV5 Dihydrofolate reductase n=18 Tax=Rhodobacterales...   180   2e-44
UniRef50_C4Z3U6 Dihydrofolate reductase n=8 Tax=Firmicutes RepID...   179   3e-44
UniRef50_Q2S5H3 Dihydrofolate reductase n=3 Tax=cellular organis...   179   4e-44
UniRef50_Q59408 Dihydrofolate reductase type A13 n=57 Tax=Bacter...   179   4e-44
UniRef50_UPI0001874368 dihydrofolate reductase n=1 Tax=Corynebac...   178   6e-44
UniRef50_P00380 Dihydrofolate reductase n=1 Tax=Enterococcus fae...   177   9e-44
UniRef50_Q13PE2 Dihydrofolate reductase n=1 Tax=Burkholderia xen...   177   1e-43
UniRef50_C3XD45 Dihydrofolate reductase n=2 Tax=Oxalobacter form...   176   2e-43
UniRef50_C3Z0P2 Putative uncharacterized protein n=2 Tax=Deutero...   176   2e-43
UniRef50_Q14P23 Putative dihydrofolate reductase oxidoreductase ...   176   2e-43
UniRef50_C5CC92 Dihydrofolate reductase n=3 Tax=Actinobacteria (...   176   2e-43
UniRef50_B8DW85 Dihydrofolate reductase n=6 Tax=Bifidobacterium ...   176   2e-43
UniRef50_UPI0001C35E5E dihydrofolate reductase region n=1 Tax=Cl...   176   2e-43
UniRef50_A7SCT0 Predicted protein n=2 Tax=Nematostella vectensis...   176   3e-43
UniRef50_B0VHY5 Dihydrofolate reductase n=1 Tax=Candidatus Cloac...   175   3e-43
UniRef50_C2HC06 Dihydrofolate reductase n=11 Tax=Enterococcus fa...   175   3e-43
UniRef50_D2RRK6 Dihydrofolate reductase n=1 Tax=Haloterrigena tu...   175   3e-43
UniRef50_Q9U8B8 Dihydrofolate reductase n=1 Tax=Heliothis viresc...   175   4e-43
UniRef50_A3K5B9 Dihydrofolate reductase n=1 Tax=Sagittula stella...   175   5e-43
UniRef50_B0MRL8 Putative uncharacterized protein n=1 Tax=Eubacte...   174   7e-43
UniRef50_Q9CBW1 Dihydrofolate reductase n=25 Tax=Actinomycetales...   174   7e-43
UniRef50_D2Q8R3 DfrA Dihydrofolate reductase n=12 Tax=Bifidobact...   174   1e-42
UniRef50_A5WHY1 Dihydrofolate reductase n=4 Tax=Moraxellaceae Re...   174   1e-42
UniRef50_A1WYQ0 Dihydrofolate reductase n=1 Tax=Halorhodospira h...   174   1e-42
UniRef50_C0QWN0 Dihydrofolate reductase n=2 Tax=Brachyspira RepI...   173   2e-42
UniRef50_Q3A0W8 Dihydrofolate reductase n=1 Tax=Pelobacter carbi...   172   3e-42
UniRef50_C7H0N2 Dihydrofolate reductase n=1 Tax=Eubacterium saph...   172   4e-42
UniRef50_C4Z7Z2 Dihydrofolate reductase n=34 Tax=Bacteria RepID=...   171   5e-42
UniRef50_C1C2C0 Dihydrofolate reductase n=1 Tax=Caligus clemensi...   171   7e-42
UniRef50_C7N8V9 Dihydrofolate reductase region n=5 Tax=Fusobacte...   171   7e-42
UniRef50_Q59487 Dihydrofolate reductase n=17 Tax=Streptococcacea...   171   7e-42
UniRef50_B7C7C2 Putative uncharacterized protein n=1 Tax=Eubacte...   171   8e-42
UniRef50_B4D395 Dihydrofolate reductase region n=1 Tax=Chthoniob...   170   9e-42
UniRef50_C5BYZ5 Dihydrofolate reductase n=1 Tax=Beutenbergia cav...   169   4e-41
UniRef50_C9KQJ5 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin...   168   4e-41
UniRef50_D1YEK5 Dihydrofolate reductase n=3 Tax=Propionibacteriu...   168   5e-41
UniRef50_UPI000186EC32 Dihydrofolate reductase, putative n=1 Tax...   168   6e-41
UniRef50_B9DU71 Dihydrofolate reductase n=13 Tax=Streptococcus R...   167   7e-41
UniRef50_C7XU42 Dihydrofolate reductase n=1 Tax=Lactobacillus co...   167   9e-41
UniRef50_C4WVU0 ACYPI002804 protein n=1 Tax=Acyrthosiphon pisum ...   167   1e-40
UniRef50_C7R3F1 Dihydrofolate reductase n=1 Tax=Jonesia denitrif...   167   1e-40
UniRef50_C8NZB9 Dihydrofolate reductase n=1 Tax=Erysipelothrix r...   167   1e-40
UniRef50_Q0G0R9 Dihydrofolate reductase n=2 Tax=Aurantimonadacea...   167   1e-40
UniRef50_Q8JKV3 Dihydrofolate reductase n=1 Tax=Heliothis zea vi...   167   2e-40
UniRef50_P17719 Dihydrofolate reductase n=21 Tax=Endopterygota R...   166   2e-40
UniRef50_B3RI81 Putative uncharacterized protein n=1 Tax=Trichop...   166   2e-40
UniRef50_C8WAC3 Dihydrofolate reductase region n=5 Tax=Coriobact...   165   6e-40
UniRef50_Q7VQK5 Dihydrofolate reductase type I n=1 Tax=Candidatu...   165   6e-40
UniRef50_C0EGY7 Putative uncharacterized protein n=1 Tax=Clostri...   165   6e-40
UniRef50_UPI0001926A4C PREDICTED: similar to Dihydrofolate reduc...   165   6e-40
UniRef50_UPI00015B4DEB PREDICTED: similar to conserved hypotheti...   165   6e-40
UniRef50_C3PEY4 Dihydrofolate reductase n=9 Tax=Corynebacterium ...   164   9e-40
UniRef50_C4QMV9 Dihydrofolate reductase n=1 Tax=Schistosoma mans...   164   1e-39
UniRef50_B9YFM0 Dihydrofolate reductase region n=3 Tax=Nostocace...   164   1e-39
UniRef50_C0VZ67 Possible dihydrofolate reductase n=3 Tax=Actinom...   163   2e-39
UniRef50_A9HP20 Dihydrofolate reductase n=1 Tax=Roseobacter lito...   163   2e-39
UniRef50_Q93341 Putative dihydrofolate reductase n=2 Tax=Caenorh...   162   3e-39
UniRef50_C7REN4 Dihydrofolate reductase region n=2 Tax=Anaerococ...   162   4e-39
UniRef50_D1AYS8 Dihydrofolate reductase region n=1 Tax=Streptoba...   161   5e-39
UniRef50_Q934V0 Putative dihydrofolate reductase n=1 Tax=Salmone...   161   5e-39
UniRef50_C2CJZ1 Possible dihydrofolate reductase n=3 Tax=Anaeroc...   161   6e-39
UniRef50_UPI000006EBF1 PREDICTED: hypothetical protein XP_002346...   161   8e-39
UniRef50_D2SDU7 Dihydrofolate reductase n=1 Tax=Geodermatophilus...   160   9e-39
UniRef50_Q4JX60 FolA protein n=3 Tax=Corynebacterium RepID=Q4JX6...   160   1e-38
UniRef50_P15093 Dihydrofolate reductase n=3 Tax=Halobacteriaceae...   159   2e-38
UniRef50_A3DES9 Dihydrofolate reductase n=5 Tax=Clostridium RepI...   159   3e-38
UniRef50_P11731 Dihydrofolate reductase type 5 n=27 Tax=Bacteria...   158   4e-38
UniRef50_C4V3M4 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphoki...   158   4e-38
UniRef50_Q86ZU9 Dihydrofolate reductase n=2 Tax=Agaricales RepID...   158   4e-38
UniRef50_A8RBH0 Putative uncharacterized protein n=1 Tax=Eubacte...   158   5e-38
UniRef50_B1V8Y8 Dihydrofolate reductase n=6 Tax=Candidatus Phyto...   158   6e-38
UniRef50_A4GI75 Dihydrofolate reductase n=1 Tax=uncultured marin...   158   6e-38
UniRef50_C5IWK1 Dihydrofolate reductase n=15 Tax=Bacteria RepID=...   158   6e-38
UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraure...   157   8e-38
UniRef50_P78218 Dihydrofolate reductase type 15 n=153 Tax=root R...   157   1e-37
UniRef50_C5RC79 Dihydrofolate reductase n=1 Tax=Weissella parame...   157   1e-37
UniRef50_B2GI60 Dihydrofolate reductase n=3 Tax=Actinomycetales ...   157   1e-37
UniRef50_P00374 Dihydrofolate reductase n=50 Tax=root RepID=DYR_...   157   1e-37
UniRef50_B7VPW7 Dihydrofolate reductase type I (Trimethoprim res...   157   1e-37
UniRef50_P00381 Dihydrofolate reductase n=9 Tax=Lactobacillus Re...   156   2e-37
UniRef50_Q6CC38 YALI0C12771p n=1 Tax=Yarrowia lipolytica RepID=Q...   156   2e-37
UniRef50_A6DQ18 Dihydrofolate reductase region n=1 Tax=Lentispha...   156   3e-37
UniRef50_UPI00017450E9 dihydrofolate reductase type III n=1 Tax=...   155   3e-37
UniRef50_P16184 Dihydrofolate reductase n=38 Tax=Pneumocystis Re...   154   7e-37
UniRef50_Q59397 Dihydrofolate reductase type 9 n=1 Tax=Escherich...   154   8e-37
UniRef50_D2NRG7 Dihydrofolate reductase n=2 Tax=Rothia mucilagin...   153   2e-36
UniRef50_A8SSS6 Putative uncharacterized protein n=2 Tax=Bacteri...   153   2e-36
UniRef50_P27422 Dihydrofolate reductase type 7 n=46 Tax=Bacteria...   153   2e-36
UniRef50_C5VBQ6 Dihydrofolate reductase n=5 Tax=Corynebacterium ...   152   2e-36

Sequences not found previously or not previously below threshold:

>UniRef50_P0ABQ5 Dihydrofolate reductase n=111 Tax=Enterobacteriaceae
           RepID=DYR_ECOL6
          Length = 159

 Score =  269 bits (690), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 159/159 (100%), Positives = 159/159 (100%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159


>UniRef50_P27498 Dihydrofolate reductase n=89 Tax=Gammaproteobacteria
           RepID=DYR_KLEAE
          Length = 159

 Score =  261 bits (668), Expect = 5e-69,   Method: Composition-based stats.
 Identities = 142/159 (89%), Positives = 152/159 (95%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAAL VDRVIGMENAMPWNL  DLAWFKRNTLNKPV+MGR TWESIGRPLPGRKNI
Sbjct: 1   MISLIAALRVDRVIGMENAMPWNLNEDLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SS+PG+DDRV WV SV+EAIAACGDV EIMVIGGGRVY++FLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSKPGSDDRVQWVSSVEEAIAACGDVEEIMVIGGGRVYDEFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDY+PD+WESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR 159


>UniRef50_P11045 Dihydrofolate reductase n=23 Tax=Firmicutes RepID=DYR_BACSU
          Length = 168

 Score =  250 bits (639), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 70/160 (43%), Positives = 102/160 (63%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS I A+  +R+IG +N +PW+LP DLA+FK+ T    +IMGR T+ESIGRPLP RKNI
Sbjct: 1   MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGRKTFESIGRPLPNRKNI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++S P ++    T V S+ + +  C    E  VIGG ++Y    P A +LY+T I  E 
Sbjct: 61  VVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYTDLFPYADRLYMTKIHHEF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD HFP+++  +W+ V SE    D +N + Y F + E++
Sbjct: 121 EGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK 160


>UniRef50_A7Z5T2 DfrA n=2 Tax=Bacillaceae RepID=A7Z5T2_BACA2
          Length = 161

 Score =  242 bits (619), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 60/160 (37%), Positives = 91/160 (56%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS I A+  +R+IG +N +PW+LP DLA+FK+ T    ++MGR T+ESIGRPLP R+NI
Sbjct: 1   MISFIFAMDENRLIGKDNDLPWHLPDDLAYFKKVTTGHTIVMGRKTFESIGRPLPNRRNI 60

Query: 61  IL-SSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++ S    +        S +E +       E  VIGG ++Y    P A +LY+T I    
Sbjct: 61  VVTSRDESSFPGCITADSAEEVLKLIPADEECFVIGGAQLYSALFPYADRLYMTKIHHVF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD  FP++   +WE    +    D +N + Y + + E++
Sbjct: 121 EGDRFFPEFNEAEWELTSRKQGVKDEKNPYDYEYLVYEKK 160


>UniRef50_P12833 Dihydrofolate reductase type 3 n=26 Tax=Proteobacteria
           RepID=DYR3_SALTY
          Length = 162

 Score =  242 bits (619), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 82/160 (51%), Positives = 112/160 (70%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA + +IG +N +PW+LPADL  FK  TL KPV+MGR T+ESIGRPLPGR+N+
Sbjct: 2   LISLIAALAHNNLIGKDNLIPWHLPADLRHFKAVTLGKPVVMGRRTFESIGRPLPGRRNV 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S  P    + V    S+D A+A   D  E M+IGGG++Y + LP+A +LYLT+IDA++
Sbjct: 62  VVSRNPQWQAEGVEVAPSLDAALALLTDCEEAMIIGGGQLYAEALPRADRLYLTYIDAQL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GDTHFPDY    W+ +    H AD +NS++  F  L R+
Sbjct: 122 NGDTHFPDYLSLGWQELERSTHPADDKNSYACEFVTLSRQ 161


>UniRef50_D0U4K0 Dihydrofolate reductase n=2 Tax=uncultured SUP05 cluster bacterium
           RepID=D0U4K0_9GAMM
          Length = 179

 Score =  239 bits (612), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 72/158 (45%), Positives = 102/158 (64%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A+  +++IG  NA+PW+LPADL +FK+ T  K V+MGR T+ESIGRPLP R+N+I
Sbjct: 21  LSIIVAMDDNQLIGKNNALPWHLPADLGYFKKVTTGKTVLMGRKTYESIGRPLPNRRNVI 80

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S       D    V S+D A+    D  E+MV+GG   YEQ LP   +LY+T I+ E +
Sbjct: 81  VSRNTNFKADGCEVVSSIDAALKLAKDDSEVMVMGGASFYEQMLPSVDRLYITQIEGEYQ 140

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD HFP ++   +  V  E H AD +N ++Y F IL+R
Sbjct: 141 GDAHFPKFDRGKFSEVSRESHTADEKNQYTYHFTILDR 178


>UniRef50_B0MUX5 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM
           17216 RepID=B0MUX5_9BACT
          Length = 160

 Score =  239 bits (611), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 62/159 (38%), Positives = 97/159 (61%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI++I A+A + VIG +N + W++  DL  FK  T   PV+MGR T+ES+GRPLPGR+N+
Sbjct: 1   MIAIIVAVAENGVIGGDNRLLWHISEDLKHFKAVTTGHPVVMGRKTYESLGRPLPGRRNV 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +++ Q  + +    V S+DEA+A      ++ VIGG ++Y Q LP   + YLT +    +
Sbjct: 61  VVTRQNISIEGCDVVHSLDEALALFRPEEKVFVIGGAQIYAQALPLCDEFYLTRVFHAYQ 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FP ++  +WE + SE   +  +  + + FE   RR
Sbjct: 121 GDTCFPRWDEREWEIIDSESFASGKEFPYPFAFEHYRRR 159


>UniRef50_Q65IB5 DfrA n=4 Tax=Bacillaceae RepID=Q65IB5_BACLD
          Length = 162

 Score =  237 bits (605), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 71/161 (44%), Positives = 98/161 (60%), Gaps = 2/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAA+  +R+IG +N +PW+LP DL +FK  T    VIMGR T+ESIGRPLP R+NI
Sbjct: 1   MISLIAAMDRNRLIGKDNDLPWHLPQDLKYFKEVTKGHAVIMGRKTFESIGRPLPHRENI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           I++S    D      + S +EA+    +   E  VIGG  +Y + LP A KLY+T ID  
Sbjct: 61  IVTSNKELDIPNCQVMHSAEEAVRFAKNRNEECFVIGGSTLYTEILPFADKLYVTKIDET 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD +FP++   +WE V       D +N + Y F + +R+
Sbjct: 121 FEGDRYFPEFSEAEWEIVSRRKGLKDDKNPYDYEFLVYQRK 161


>UniRef50_Q1LK80 Dihydrofolate reductase n=3 Tax=Proteobacteria RepID=Q1LK80_RALME
          Length = 166

 Score =  236 bits (602), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 66/159 (41%), Positives = 93/159 (58%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +++LI A A + VIG  N +PW LP DL  FKR T+  P+IMGR TW+SIGRPLPGR+NI
Sbjct: 3   LLTLIVARARNGVIGRNNTLPWRLPEDLQHFKRTTMGAPIIMGRKTWDSIGRPLPGRRNI 62

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++       +    V S+++A   C    ++ +IGG ++Y + LP A +L +T IDA+V
Sbjct: 63  VVTRNRDLHIEGADVVGSIEDAQRLCIGAEQVFLIGGAQLYAEALPSADRLIVTEIDADV 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGD  FP  +   W     E H +   N   Y F   ER
Sbjct: 123 EGDAFFPAVDRTTWVETARELHHS-ETNGFDYAFVTYER 160


>UniRef50_A1U3D7 Dihydrofolate reductase n=6 Tax=Gammaproteobacteria
           RepID=A1U3D7_MARAV
          Length = 171

 Score =  235 bits (600), Expect = 4e-61,   Method: Composition-based stats.
 Identities = 69/164 (42%), Positives = 100/164 (60%), Gaps = 8/164 (4%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           +LI A+A +RVIG  N +PW LP DL +FK+ T+ KP+IMGR TW+SIGRPLPGR N+++
Sbjct: 4   ALIVAMARNRVIGRNNKLPWYLPGDLRYFKQATMGKPIIMGRKTWDSIGRPLPGRMNVVI 63

Query: 63  SSQP--GTDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           S  P            S++EA+      A      E+M+IGGG++Y + LP   ++Y+T 
Sbjct: 64  SRNPEWQAPAGTVAAASLNEALVKAEAQANLEGGDEVMIIGGGQIYAEALPMVDRIYITQ 123

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + AEV+GD  FP+   D+WE +  E   A   N + Y F + +R
Sbjct: 124 VHAEVDGDAFFPEVNWDEWEEIGREDFSASDNNPYDYSFVVYQR 167


>UniRef50_D2QJY0 Dihydrofolate reductase n=2 Tax=Bacteria RepID=D2QJY0_9SPHI
          Length = 163

 Score =  234 bits (599), Expect = 5e-61,   Method: Composition-based stats.
 Identities = 71/160 (44%), Positives = 104/160 (65%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAA+A + VIG EN +PW+LP D A+FKR T + P+IMGR + ES+G+PLP R NI+
Sbjct: 3   ISLIAAVAQNGVIGRENDLPWHLPDDFAFFKRKTSHHPIIMGRKSLESLGKPLPNRTNIV 62

Query: 62  LSSQ-PGTDDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           L+     +   VT V ++D+AIA     +  EI VIGG  +Y+  LP A  LYLT I  +
Sbjct: 63  LTRNAEFSAAGVTIVHTLDDAIAEAKAINQTEIFVIGGAEIYKMALPIATTLYLTEIHQD 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            +GD +FP+++ ++W+ V    H AD +++ S+ F   E+
Sbjct: 123 YDGDAYFPEFDKNEWQEVSRRPHPADERHAVSFDFVEYEK 162


>UniRef50_D0KZ69 Dihydrofolate reductase n=2 Tax=Gammaproteobacteria
           RepID=D0KZ69_HALNC
          Length = 177

 Score =  234 bits (598), Expect = 8e-61,   Method: Composition-based stats.
 Identities = 82/159 (51%), Positives = 104/159 (65%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I L+AAL  ++VIG  NA+PW+LPADL  FK+ T+ KP+IMGR T++SIGRPLPGRKNI+
Sbjct: 3   IGLVAALTRNQVIGRYNALPWSLPADLQRFKKITMGKPIIMGRKTYDSIGRPLPGRKNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119
           +S  P    D VT V S+D A+ A    PE+MVIGG  +Y QFLP+A +LY T +   + 
Sbjct: 63  ISRNPDFHADGVTVVDSLDMALEAADQAPEVMVIGGANIYYQFLPRADRLYFTLVHTTID 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GD  FP Y   DW  V  E H ADA N   Y F   +R
Sbjct: 123 DGDAFFPAYNRRDWRLVIEENHPADADNPFPYSFMTWQR 161


>UniRef50_A4Y040 Dihydrofolate reductase n=28 Tax=Proteobacteria RepID=A4Y040_PSEMY
          Length = 176

 Score =  231 bits (590), Expect = 6e-60,   Method: Composition-based stats.
 Identities = 79/165 (47%), Positives = 103/165 (62%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAALA +RVIG +N +PW+LPADL  FK  TL KP+IMGR TW+S+GRPLPGR NI+
Sbjct: 11  LSLIAALADNRVIGRDNQLPWHLPADLKHFKALTLGKPIIMGRKTWDSLGRPLPGRLNIV 70

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S Q G T +      +++EAI          D  E+M+IGG ++YE  L +A +LYLT 
Sbjct: 71  VSRQAGLTLEGAEVFATLEEAIKRADAWAREEDAEELMLIGGAQLYELGLEQADRLYLTR 130

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +  E EGD  FP  +   W    S  H A A+    Y FE+ ERR
Sbjct: 131 VGLEPEGDAFFPQIDESAWRMTSSVEHPASAETPF-YAFEVWERR 174


>UniRef50_Q3JEI1 Dihydrofolate reductase n=3 Tax=Gammaproteobacteria
           RepID=Q3JEI1_NITOC
          Length = 165

 Score =  230 bits (587), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 71/159 (44%), Positives = 103/159 (64%), Gaps = 1/159 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS I A+  + +IG    +PW+LPADL +F+R T+ KP++MGR T E+IGRPLPGR NI
Sbjct: 2   IISFIVAMDENHLIGANRRLPWHLPADLKYFRRMTMGKPMLMGRSTHEAIGRPLPGRHNI 61

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++  P       T V +V+  + A G+  E+ VIGG  +YEQ LP+A+++YLT +    
Sbjct: 62  VVTHNPDYKAPGCTVVHTVEAGLQAAGEAEEVTVIGGASLYEQLLPQARRIYLTLVRGHF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GDT FP ++P  W  V+ E +D D QN + Y F  LER
Sbjct: 122 QGDTWFPAFDPGTWVEVWREDYDPDPQNPYPYSFIRLER 160


>UniRef50_A9KH09 Dihydrofolate reductase n=8 Tax=Coxiella burnetii
           RepID=A9KH09_COXBN
          Length = 161

 Score =  230 bits (587), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 67/159 (42%), Positives = 106/159 (66%), Gaps = 1/159 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +I+LIAA+  +R+IG  N +PW+LPADLA FK  TL KP++MGR T++SIG+PLP R+NI
Sbjct: 2   IITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSIGKPLPHRRNI 61

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++ Q     +      S+D+A++A    PE+++IGG R++++ LPKA K+ LT I+   
Sbjct: 62  VITQQKNLIIEGCDIFYSLDDALSALTKEPEVIIIGGARIFKEALPKADKMILTIINHSF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGD +FP++   +W+      H+ D +N + + F  L R
Sbjct: 122 EGDVYFPEWNDKEWKITSQIKHERDEKNPYPFQFLELRR 160


>UniRef50_Q31I54 Dihydrofolate reductase n=32 Tax=Bacteria RepID=Q31I54_THICR
          Length = 175

 Score =  229 bits (586), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 73/160 (45%), Positives = 113/160 (70%), Gaps = 2/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           IS+IAA+   R+IG +N MPW+LP DL +FK NT+NKPVIMGR T+ESIG +PLP R+N+
Sbjct: 14  ISMIAAMDKHRIIGADNDMPWHLPDDLKFFKANTVNKPVIMGRKTFESIGSKPLPNRRNL 73

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++     + +      S +EA+ +C    EI+++GGG++Y Q +P A KLY+T +DAEV
Sbjct: 74  VITRNDAYEANGAEVFHSAEEALKSCKSEVEIIIMGGGQLYAQMMPFANKLYVTLVDAEV 133

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GDT FP++  D+W+ +  E+HD D ++++++ F  L R+
Sbjct: 134 AGDTTFPEWLTDEWQEISKEWHDKDERHAYAFEFVTLIRK 173


>UniRef50_P43791 Dihydrofolate reductase n=19 Tax=Gammaproteobacteria
           RepID=DYR_HAEIN
          Length = 160

 Score =  229 bits (586), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 84/158 (53%), Positives = 107/158 (67%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
            SLI A  ++ VIG +N MPW+LPADLAWF++NT  KPVIMGR T+ESIGRPLP R NI+
Sbjct: 3   FSLIVATTLNNVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           LS Q    + V W  S + A+    D  EIM+IGGG +++Q+LPKA KLYLT I  E++G
Sbjct: 63  LSRQLFEHEGVIWKDSFESAVNFVRDFDEIMLIGGGELFKQYLPKADKLYLTQIQTELDG 122

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DT FP    ++WE  F E+  AD QN +   F IL R+
Sbjct: 123 DTFFPQLNWEEWEIEFDEYRKADEQNRYDCRFLILTRK 160


>UniRef50_A9I779 FolA protein n=2 Tax=Bordetella RepID=A9I779_BORPD
          Length = 178

 Score =  229 bits (586), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 69/159 (43%), Positives = 95/159 (59%), Gaps = 3/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++L+ A + +RVIG +N +PW LP DLA FKR TL  P+IMGR TWES+GRPLPGR N++
Sbjct: 21  LTLVVAYSDNRVIGRDNTLPWKLPGDLAHFKRTTLGSPIIMGRKTWESLGRPLPGRTNVV 80

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S          T V ++  A+ ACGD P+  VIGG ++Y Q LP A ++  T + A VE
Sbjct: 81  ISRNLRYAAPGATVVPTLQAAVEACGDAPDAYVIGGAQIYAQALPLAARVIATEVHAHVE 140

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GD  FP      W     +   A  +N + Y F + ER+
Sbjct: 141 GDAFFPYLPSFAWREASRQPQPA--ENGYDYDFVVYERQ 177


>UniRef50_Q5R038 Dihydrofolate reductase n=3 Tax=Alteromonadales RepID=Q5R038_IDILO
          Length = 166

 Score =  229 bits (585), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 85/162 (52%), Positives = 117/162 (72%), Gaps = 5/162 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISL+ A+A +RVIG +N MPW+LP +L +FK+ TL KP++MGR T+ESIGRPLPGRKNI+
Sbjct: 3   ISLVVAMADNRVIGKDNKMPWHLPDELQYFKKITLGKPIVMGRRTFESIGRPLPGRKNIV 62

Query: 62  LSSQPGTDDR----VTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           LS +    +     V WV  V +AIAA G V E+M+IGGG++YE+FLP A +LY+T I+ 
Sbjct: 63  LSRRTDRSENQDSQVVWVSGVQQAIAAAGPVEELMIIGGGKIYEKFLPLADRLYVTKIEL 122

Query: 118 EVEGDTHFPDY-EPDDWESVFSEFHDADAQNSHSYCFEILER 158
            VEGDT+FPDY +  DW+ +  +   AD +NSH++   I +R
Sbjct: 123 NVEGDTYFPDYHQVADWQEIERQNFAADERNSHNFSTLIFDR 164


>UniRef50_C2FZ23 Dihydrofolate reductase n=2 Tax=Sphingobacterium spiritivorum
           RepID=C2FZ23_9SPHI
          Length = 164

 Score =  227 bits (579), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 70/159 (44%), Positives = 96/159 (60%), Gaps = 1/159 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+LI A A + VIG +N MPW+LP D  +FK+NTL   VIMGR T+E+IG+ LP R+NI+
Sbjct: 6   ITLIVAAAENNVIGKDNQMPWHLPNDFKYFKKNTLEHSVIMGRKTFEAIGKALPDRRNIV 65

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S         V    S+ EAI  C D  E+ VIGG  +YEQ LP A K+ LT +   +E
Sbjct: 66  ISRNQDFHHPDVDTANSLQEAILYCRDEREVFVIGGANIYEQTLPFAHKVLLTRVHTTIE 125

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GD  FP   P++W     E H AD +++  Y F++  R+
Sbjct: 126 GDAVFPVLNPEEWMLESEEKHFADDKHAFDYTFQVFNRK 164


>UniRef50_Q0VM07 Dihydrofolate reductase n=5 Tax=Gammaproteobacteria
           RepID=Q0VM07_ALCBS
          Length = 171

 Score =  227 bits (579), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 70/165 (42%), Positives = 101/165 (61%), Gaps = 7/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S++ A A + VIG  N +PW LP DL +FK+ T  KPVIMGR TWES+  PLPGR NI+
Sbjct: 7   LSMMVAKATNNVIGRNNKLPWYLPNDLKYFKQVTFGKPVIMGRKTWESLKGPLPGRTNIV 66

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++ QP    +    V +VD+AI    +V       E +++GG  +Y   L + Q+LYLT 
Sbjct: 67  ITRQPAYQAEGAKVVATVDDAITMAENVAFIEGQEEAVIMGGAEIYALALAQTQRLYLTE 126

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + AEV+GDT FP+Y+  +WE +  E   A+  N + Y F + ER+
Sbjct: 127 VHAEVDGDTFFPEYDKGEWEEIAREDFPAEGPNPYDYSFVVYERK 171


>UniRef50_Q2Y7L3 Dihydrofolate reductase n=7 Tax=Betaproteobacteria
           RepID=Q2Y7L3_NITMU
          Length = 183

 Score =  226 bits (577), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 70/169 (41%), Positives = 102/169 (60%), Gaps = 14/169 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S++ A+A +R IG +NA+PW+LP DL  FK  T+  P+IMGR T+ESIGR LPGR +II
Sbjct: 5   LSVLVAMARNRAIGHKNAIPWHLPHDLKHFKELTMGHPMIMGRKTYESIGRLLPGRTSII 64

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDV-----------PEIMVIGGGRVYEQFLPKAQK 109
           ++ QP  +      V S+ EA++AC  +            E  VIGG  +++Q LP   +
Sbjct: 65  ITRQPDYEVPGALVVSSIGEALSACKQIRSGEEGHPDQGNECFVIGGADIFQQMLPLCDR 124

Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           LY+T I  + EGDT+FP+++ +DW  V  E H  D+     Y F  L+R
Sbjct: 125 LYMTEIHRDFEGDTYFPEFDRNDWWEVSREEHVDDS--GLEYHFVTLDR 171


>UniRef50_A5FJX2 Dihydrofolate reductase n=1 Tax=Flavobacterium johnsoniae UW101
           RepID=A5FJX2_FLAJ1
          Length = 160

 Score =  224 bits (572), Expect = 8e-58,   Method: Composition-based stats.
 Identities = 59/160 (36%), Positives = 91/160 (56%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI +IAA+A +  +G  N + W+LP D   FK  T N  +IMGR T+ES  +PLP R +I
Sbjct: 1   MIIMIAAVAENNTLGKNNELVWHLPNDFKRFKSLTTNHHIIMGRKTFESFPKPLPNRTHI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++ Q   + +    V S+++AIAAC +  +  +IGGG +Y   LP A  + +T +    
Sbjct: 61  IITRQTDYNPEGCIVVDSMEKAIAACPENEDSYIIGGGEIYNLGLPYADIIEITKVHHTF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD  FP     +W+ V SE +  D ++ + Y +E   R+
Sbjct: 121 EGDAFFPKISKSEWQLVESEENFKDEKHLYDYTYETYIRK 160


>UniRef50_C7PKU6 Dihydrofolate reductase n=1 Tax=Chitinophaga pinensis DSM 2588
           RepID=C7PKU6_CHIPD
          Length = 164

 Score =  223 bits (569), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 60/160 (37%), Positives = 102/160 (63%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A + + VIG+ N +PW+LP D+ +FK  T+ KP++MGR ++E +GR LPGR NI+
Sbjct: 3   LSIIVAASENNVIGINNHLPWHLPVDMKYFKDTTMGKPIVMGRKSFEELGRVLPGRPNIM 62

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++ Q     + +  V S++  I         EI V GGG +++  L    ++YLT + A 
Sbjct: 63  ITRQKDYTAEGLHIVPSLEAGIEKAKTFGTEEIFVTGGGEIFKMALSIVDRVYLTRVHAT 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           V+GDT+FP+++P  W+ V +E H+ D +++H+  F++ ER
Sbjct: 123 VQGDTYFPEFDPRGWKLVKNERHEKDEKHAHALTFQVWER 162


>UniRef50_A0AJX9 DfrA protein n=15 Tax=Listeria RepID=A0AJX9_LISW6
          Length = 160

 Score =  223 bits (569), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 60/159 (37%), Positives = 90/159 (56%), Gaps = 1/159 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI  + A      IG +N MPW+LP DL +FK+ T  K ++MGR T+ES+G+ LP RK I
Sbjct: 1   MIIFVWAQDRAGNIGKDNTMPWHLPGDLQFFKKTTTGKTLVMGRKTYESLGKALPNRKTI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L+       D    + S +E +A       I V+GG  +Y  F+  A KL +T IDAE 
Sbjct: 61  VLTRDKELQLDDAEILHSREEVLALTQTGEPIYVVGGAEIYRLFMDVADKLIVTKIDAEF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + DT FP+ + +++  +  E H+ D +N ++Y F   ER
Sbjct: 121 DADTAFPEVDWENFSEIAKEPHEKDEKNKYNYTFYTYER 159


>UniRef50_Q2SXY8 Dihydrofolate reductase n=18 Tax=Proteobacteria RepID=Q2SXY8_BURTA
          Length = 219

 Score =  222 bits (567), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 67/161 (41%), Positives = 95/161 (59%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 56  LTLIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 115

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D      S+ +A+A        E  +IGG ++Y + L  A KL +T ID +
Sbjct: 116 VTRDAARRFDGCDTATSLGDALALAERDGAAEAFLIGGAQLYAEGLRHADKLIVTEIDQD 175

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD  FP  +P  WE+V  + H A   N  +Y F +  R+
Sbjct: 176 FEGDASFPAPDPAQWEAVSRDAHRAAPPNDFAYAFVVYRRK 216


>UniRef50_C6P459 Dihydrofolate reductase n=1 Tax=Sideroxydans lithotrophicus ES-1
           RepID=C6P459_9PROT
          Length = 177

 Score =  221 bits (565), Expect = 5e-57,   Method: Composition-based stats.
 Identities = 54/158 (34%), Positives = 83/158 (52%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLI A+A +R IG+ N +PW  P DL  FK  T+   +IMGR T++SIG+PLPGR  ++
Sbjct: 19  LSLIVAMARNRTIGVNNTLPWRCPEDLKHFKTLTMGHHMIMGRKTFDSIGKPLPGRTTVV 78

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++     + +      S+ EA+  C    EI V+GG  +Y Q +     LY+T I  +V 
Sbjct: 79  ITRNNDLEIEGCIVAHSLQEALVTCAGDEEIFVVGGAELYRQAISLVDTLYVTEIQQDVA 138

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD HFP+ +   W+    E    +      + F    +
Sbjct: 139 GDAHFPEIDKAFWQETSREMRSQETPQPMDFHFVTYRK 176


>UniRef50_UPI0001787F40 Dihydrofolate reductase n=1 Tax=Geobacillus sp. Y412MC10
           RepID=UPI0001787F40
          Length = 162

 Score =  221 bits (565), Expect = 5e-57,   Method: Composition-based stats.
 Identities = 71/163 (43%), Positives = 103/163 (63%), Gaps = 5/163 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MIS+I A+  D+VIG+   MPW LP D+A+FK  TL+K ++MGR TW+S G +PLP RKN
Sbjct: 1   MISMIWAMGKDQVIGLNGTMPWRLPRDMAFFKEKTLHKTILMGRKTWDSFGGKPLPHRKN 60

Query: 60  IILSSQPG---TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+L+       T+D+   +  ++ A+    +  E+MVIGG ++YE  LPKA +LY T ID
Sbjct: 61  IVLTRDESFTLTEDQGIVIHDIENALPYSKN-EELMVIGGSQIYELMLPKADRLYCTFID 119

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
              EGDT+FP+   D+W+ V       D +N ++Y F   ER+
Sbjct: 120 ESFEGDTYFPEVNWDEWKIVEEVPGITDEKNPYAYRFVTFERK 162


>UniRef50_Q15PF1 Dihydrofolate reductase n=18 Tax=Gammaproteobacteria
           RepID=Q15PF1_PSEA6
          Length = 171

 Score =  221 bits (565), Expect = 5e-57,   Method: Composition-based stats.
 Identities = 81/168 (48%), Positives = 107/168 (63%), Gaps = 11/168 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+++AA+A  RVIG+ N MPW++PADL  FKR TL KP++MGR T+ESIGR LPGR NI+
Sbjct: 4   IAMVAAMANQRVIGLNNQMPWHMPADLKHFKRITLGKPIVMGRKTYESIGRALPGRLNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAAC----------GDVPEIMVIGGGRVYEQFLPKAQKL 110
           ++S         + V S ++AIA                E+MVIGGG VY+ FLP A +L
Sbjct: 64  ITSDQNYQLADASIVHSCEQAIAVATSHMQNDGMPEHDQEVMVIGGGTVYQHFLPHANRL 123

Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           YLT ID +  GDT+FP+Y    W+ + SE +D D +N HSY F  L R
Sbjct: 124 YLTFIDLDTPGDTYFPNYSDGAWQEIESESNDPDEKNPHSYRFVTLAR 171


>UniRef50_C1XJD1 Dihydrofolate reductase n=1 Tax=Meiothermus ruber DSM 1279
           RepID=C1XJD1_MEIRU
          Length = 171

 Score =  221 bits (563), Expect = 8e-57,   Method: Composition-based stats.
 Identities = 62/159 (38%), Positives = 94/159 (59%), Gaps = 5/159 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+ + A+  +R IG    +PW+LP DL  F+  TL K V+MGR T+ESIGRPLP R+N++
Sbjct: 5   IAFVVAMDQNRAIGRAGTLPWHLPDDLKRFRALTLGKTVLMGRKTFESIGRPLPKRRNVV 64

Query: 62  LSSQP-GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119
           L+  P    + V  V ++++A+       E+MVIGGG +Y  FLP    L+LT ++  V 
Sbjct: 65  LTRDPAFAAEGVEVVHTLEDALKL---DDELMVIGGGEIYTLFLPLVTHLHLTLVETVVP 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + D  FP + P  W   + E H AD ++  ++ +  LER
Sbjct: 122 DADAFFPPWNPTGWRETYREHHPADERHPWAFTYLDLER 160


>UniRef50_A1AXR7 Dihydrofolate reductase n=6 Tax=Proteobacteria RepID=A1AXR7_RUTMC
          Length = 163

 Score =  220 bits (562), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 62/158 (39%), Positives = 102/158 (64%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A+  +++IG  NA+PW LPADLA+FK+ T+ K V+MGR T++SIGRPL  R+NII
Sbjct: 3   LSIIVAMDDNQLIGKNNALPWYLPADLAYFKKTTIGKAVLMGRKTYDSIGRPLSNRRNII 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S       D    V S++ A+       E+M++GG   YEQ + K  ++Y+T ++ + +
Sbjct: 63  VSRNTKLKVDGCEVVGSINVALNLVNGANELMIMGGVSFYEQMIDKVDRIYITEVNGKFD 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT+FP+++   +  +  E H  D +N H++ F IL++
Sbjct: 123 GDTYFPEFDRTKFSELSRESHQPDEKNLHAHNFVILQK 160


>UniRef50_A7HVX5 Dihydrofolate reductase n=13 Tax=Proteobacteria RepID=A7HVX5_PARL1
          Length = 169

 Score =  219 bits (560), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 67/165 (40%), Positives = 97/165 (58%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           +S + A+A + VIG +N++PW L  D+A+FKR T+ KPVIMGR TWES+ R PLPGR NI
Sbjct: 3   VSYVVAIADNGVIGRDNSLPWRLSGDMAFFKRITMGKPVIMGRKTWESLPRKPLPGRPNI 62

Query: 61  ILSSQPGTD-DRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++     + +      S  EA+      A+     E+MVIGG ++Y +    A +LY+T
Sbjct: 63  VVTRDAQYEAEGAEIAASAVEALRRGRELASASGADEVMVIGGAQLYAEMFDDATRLYIT 122

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            + A  EGD  FP ++   W  V  E H A  ++S  Y F +LER
Sbjct: 123 EVHAAPEGDVSFPAFDAAHWREVSRERHKAGEKDSADYSFVVLER 167


>UniRef50_C6X2F4 Dihydrofolate reductase n=20 Tax=Bacteroidetes RepID=C6X2F4_FLAB3
          Length = 167

 Score =  219 bits (560), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 61/161 (37%), Positives = 93/161 (57%), Gaps = 2/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI+++ A+ +   IG +N + W+LP DL  FK  T   P+IMGR T+ESIGRPLP R NI
Sbjct: 1   MITIVVAMGLKNEIGADNQLLWHLPQDLKHFKEITTGHPIIMGRKTYESIGRPLPNRTNI 60

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++S +     + V  V S+ EA+     + E + VIGGG +YEQ +  A KL +T + AE
Sbjct: 61  VVSRKKDWFAEGVLIVGSLKEALKFAKKIDENVFVIGGGNIYEQTIDLADKLEVTLVKAE 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +  D  FP  +   WE       D D ++++ +CF+   ++
Sbjct: 121 INADIFFPKIDLKIWEKTSETCIDKDEKHAYDFCFQTFVKK 161


>UniRef50_Q67JQ2 Dihydrofolate reductase n=1 Tax=Symbiobacterium thermophilum
           RepID=Q67JQ2_SYMTH
          Length = 165

 Score =  219 bits (558), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 66/153 (43%), Positives = 87/153 (56%), Gaps = 4/153 (2%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67
           +  +R IG E  +PW LPA++  F+R T+ K V+MGR T+ESIG PL GR NI+L+  PG
Sbjct: 1   MGRNRAIGREGRLPWRLPAEMRHFRRTTMGKAVVMGRRTYESIGGPLKGRTNIVLTRDPG 60

Query: 68  T-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126
                     SV E +    D   + VIGG  VY QFLP A ++ LT ID + EGD  FP
Sbjct: 61  FRAPGCEVRHSVAELLQ---DRRPLYVIGGAEVYRQFLPHADEMILTRIDHDFEGDAFFP 117

Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +  D+WE V S  H  D +N + +  E   RR
Sbjct: 118 AWSEDEWELVGSTPHPRDEENPYDFVVEHYRRR 150


>UniRef50_A2SN57 Dihydrofolate reductase n=34 Tax=Burkholderiales RepID=A2SN57_METPP
          Length = 259

 Score =  219 bits (558), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 68/163 (41%), Positives = 93/163 (57%), Gaps = 5/163 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           +++IAA A + VIG  N +PW LP DLA F+  T   PVIMGR TWES+    RPLPGR+
Sbjct: 3   LAIIAACARNGVIGRNNDLPWRLPEDLAHFRSTTGGWPVIMGRLTWESLPARFRPLPGRR 62

Query: 59  NIILSSQ--PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           NII+S     G    V  V S++ A+          VIGG R+YE  LP A +L+LT ID
Sbjct: 63  NIIVSRGGVRGVPKGVDVVASLEAALELVQAERRAFVIGGARLYEAALPLADELFLTEID 122

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + EGD +FP+++   +         A+A N+ +Y F    R+
Sbjct: 123 EDFEGDVYFPEFDRSAFVEHHRMRRQAEAPNTFTYSFAHYRRK 165


>UniRef50_A5EUV9 Dihydrofolate reductase n=1 Tax=Dichelobacter nodosus VCS1703A
           RepID=A5EUV9_DICNV
          Length = 164

 Score =  218 bits (557), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 63/159 (39%), Positives = 92/159 (57%), Gaps = 1/159 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I LIAA  ++RVIG +  MPW+LP DL  FK+ T    +IMGR T++S+ +PLP RKNI+
Sbjct: 6   IHLIAAQTLNRVIGKDGGMPWHLPRDLQHFKQRTSGHTIIMGRKTFQSLKKPLPNRKNIV 65

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S         V    ++ EA+A C +  ++ +IGGG +Y   + +A  L +T I  E+ 
Sbjct: 66  ISHSGQPLHADVAVFPAISEALAFCCNDEKVFIIGGGSLYAATIDEADFLTITWIHTELL 125

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FP   P DW+        ADA+N+ +  F   +RR
Sbjct: 126 GDTFFPPIRPQDWQETHRSHFAADAKNAFALDFVDYQRR 164


>UniRef50_C0YTZ2 Possible dihydrofolate reductase type I involved in trimethoprim
           resistance n=1 Tax=Chryseobacterium gleum ATCC 35910
           RepID=C0YTZ2_9FLAO
          Length = 165

 Score =  218 bits (557), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 61/160 (38%), Positives = 93/160 (58%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M +++ A+     IG EN + W+LP DL  FK  T   PVIMGR T+ESIG+ LP R NI
Sbjct: 1   MTTIVVAMGEKNEIGFENQLLWHLPKDLKHFKEITSGHPVIMGRKTYESIGKALPNRTNI 60

Query: 61  ILSSQPG-TDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++S +    ++ +  V S+ EA+     +  E+ VIGGG +YEQ +    +L +T + A+
Sbjct: 61  VVSRKKDWFEEGILIVGSIKEALKFAKKIDEEVFVIGGGNIYEQTMDVVDRLEVTLVKAD 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +E DT FP  +P  W+      H+ D +N + +CF+  ER
Sbjct: 121 LEADTFFPKIDPKIWKMTNEICHEKDEKNGYDFCFQTFER 160


>UniRef50_Q3K556 Dihydrofolate reductase n=8 Tax=Bacteria RepID=Q3K556_PSEPF
          Length = 170

 Score =  217 bits (555), Expect = 6e-56,   Method: Composition-based stats.
 Identities = 71/164 (43%), Positives = 105/164 (64%), Gaps = 8/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAAL  +RVIG++N+MPW+LP D  +FK  TL KP+IMGR TW+S+GRPLPGR NI+
Sbjct: 7   LSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNIV 66

Query: 62  LSSQPGTD-DRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S Q G   +      S++ A+      A    V E+M+IGG ++Y Q L +A +LYLT 
Sbjct: 67  VSRQAGLVLEGAEVYPSLEAAVVRAEEWAKDQGVDELMLIGGAQLYAQGLAQADRLYLTR 126

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +    EGD  FP+++ + W+ V +  + A   +  +Y FE+ E+
Sbjct: 127 VALSPEGDAWFPEFDLNQWKLVSNVPNPA-EGDKPAYNFEVWEK 169


>UniRef50_C7RLL7 Dihydrofolate reductase n=1 Tax=Candidatus Accumulibacter
           phosphatis clade IIA str. UW-1 RepID=C7RLL7_9PROT
          Length = 169

 Score =  217 bits (555), Expect = 8e-56,   Method: Composition-based stats.
 Identities = 62/169 (36%), Positives = 89/169 (52%), Gaps = 10/169 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           MISLIAA+A +  IG    + W LP D+ +F+  T  K VIMGR TWES+    RPLP R
Sbjct: 1   MISLIAAVARNGAIGRNQQLLWRLPEDMRYFRETTSGKTVIMGRKTWESLPPAYRPLPNR 60

Query: 58  KNIILSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +NI+LS  P           S+++A+   G   E+ +IGG  +Y Q +P A +LY+T + 
Sbjct: 61  RNIVLSRNPAYLPRGGDLACSIEDALRLAGGAAEVFIIGGEELYRQTMPLATRLYITEVA 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADA------QNSHSYCFEILERR 159
            E  GD  FPD    +W  +      + A        + ++ F + ERR
Sbjct: 121 EESPGDAFFPDVASGEWREISRRVGRSRAAGSALRDQAPAFDFVVYERR 169


>UniRef50_B8KL97 Dihydrofolate reductase n=1 Tax=gamma proteobacterium NOR5-3
           RepID=B8KL97_9GAMM
          Length = 182

 Score =  217 bits (554), Expect = 8e-56,   Method: Composition-based stats.
 Identities = 68/165 (41%), Positives = 99/165 (60%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+LI A A + VIG +NA+PW LP DLA FKR T+ KP++MGR T+ESIGRPLPGR NI+
Sbjct: 6   IALIVAAADNDVIGRDNALPWQLPGDLAHFKRTTMGKPILMGRLTYESIGRPLPGRTNIV 65

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S  PG     V  V+S+++A+    D+       E+M+IGG ++Y   LP A ++YLT 
Sbjct: 66  ISRDPGYSAAGVRSVQSLEKALELAKDIAVIDGSSELMIIGGAQIYALALPLASRIYLTR 125

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +  E  GD   P  +   W+    + + AD  +  ++ F    R+
Sbjct: 126 VHVEPAGDAFLPAIDWAHWKESGRQENPADG-SVPAHTFLEYTRQ 169


>UniRef50_C6CYL9 Dihydrofolate reductase n=1 Tax=Paenibacillus sp. JDR-2
           RepID=C6CYL9_PAESJ
          Length = 163

 Score =  217 bits (553), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 69/160 (43%), Positives = 102/160 (63%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+   R IG+ N +PW LPA++A+F R+T  K V+MGR T+ES+ +PL  R N++
Sbjct: 3   ITMIAAMDRGRTIGIGNKLPWRLPAEMAYFTRHTTGKAVVMGRKTFESLPKPLKDRTNVV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++ QP    +    V SV EAI   G+  E+MVIGG  +Y QFLP A K+ LT +D  +E
Sbjct: 63  ITRQPEYAKEGCEVVHSVQEAIDRYGEG-ELMVIGGADIYAQFLPFADKIRLTEVDTNIE 121

Query: 121 -GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GD  FP +   +WE V +E  ++D +N+ S+ F+   RR
Sbjct: 122 GGDAFFPTFNEGEWERVDAEKVESDERNAFSFTFQTFARR 161


>UniRef50_Q1QUE0 Dihydrofolate reductase n=12 Tax=Bacteria RepID=Q1QUE0_CHRSD
          Length = 195

 Score =  217 bits (553), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 67/167 (40%), Positives = 98/167 (58%), Gaps = 10/167 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+L+AA++ +RVIG++N +PW+LP DL +FK  T++KP++MGR T+ESIGRPLPGR NI+
Sbjct: 19  IALVAAMSRNRVIGVDNKLPWHLPEDLKFFKAVTMSKPLVMGRKTFESIGRPLPGRLNIV 78

Query: 62  LSSQPGT---DDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112
           ++   G     D +     +  A+      A    V +I VIGGG ++ + LP A +LYL
Sbjct: 79  VTRDRGYAQDHDGIRVCHDLASALDMADGQAIIDGVEDICVIGGGEIFAEALPCATRLYL 138

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T +D EVEGD  FP ++  +W+                Y F    RR
Sbjct: 139 TEVDIEVEGDAWFPAFDAREWQETQRVPGQGGE-GKPEYAFVHYTRR 184


>UniRef50_C9RIZ1 Dihydrofolate reductase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RIZ1_FIBSS
          Length = 163

 Score =  217 bits (553), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 60/162 (37%), Positives = 87/162 (53%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS I A++ + VIG +  +PW+L ADL  FK  T    +I+GR  ++ IGRPLP R N 
Sbjct: 2   LISAIVAVSENNVIGRDGHLPWHLSADLKRFKAITTGHAIILGRKNYDDIGRPLPNRTNY 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAA--CGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +L+              S+ EAI A       E  +IGG  VY + +P  +KLYLT + +
Sbjct: 62  VLTRNKDFQAPGCIVCSSLGEAIEAARAAGETECFIIGGAAVYREAMPLVEKLYLTRVLS 121

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            VEGD  FP++  D ++   +E   AD +N     FEI  R+
Sbjct: 122 HVEGDVFFPEWN-DKFQKESAESFPADEKNDFPTTFEIWVRK 162


>UniRef50_Q2K6G9 Dihydrofolate reductase protein n=3 Tax=Rhizobiales
           RepID=Q2K6G9_RHIEC
          Length = 172

 Score =  216 bits (552), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 65/164 (39%), Positives = 100/164 (60%), Gaps = 7/164 (4%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           ++IAA+A +  IG E  MPW L +DL  FK  TL KPV+MGR T++SIG+PLPGR N+++
Sbjct: 7   TIIAAVARNGTIGREGDMPWRLSSDLKRFKTLTLGKPVVMGRRTYDSIGKPLPGRPNVVI 66

Query: 63  SSQPGTD-DRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           S Q   D   ++   S+ EA+ A           EI +IGGG++Y Q +  A ++Y+TH+
Sbjct: 67  SRQAAIDHSDISMAHSLAEALEAAERLALQTGAGEICIIGGGQIYAQAIDLADRMYITHV 126

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +A+++GD  FP  +P  W++       A  ++S+   F + ERR
Sbjct: 127 EADLDGDAFFPAIDPGTWQAGEVVAVPAGERDSYPTRFVVYERR 170


>UniRef50_A5GBA2 Dihydrofolate reductase n=2 Tax=Geobacter RepID=A5GBA2_GEOUR
          Length = 163

 Score =  216 bits (551), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 69/160 (43%), Positives = 98/160 (61%), Gaps = 6/160 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAA+A +RVIG  NA+PW++PAD   F+  TL  PVIMGR T+ES+  PLPGRKNI
Sbjct: 2   VISLIAAMAENRVIGRNNAIPWDIPADRKRFRALTLGHPVIMGRKTFESLAGPLPGRKNI 61

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++ Q     +       +  A+A  G+  EI + GGG +Y Q LP A ++YLT I +  
Sbjct: 62  IITRQMDYRAEGCFIAHDLASALAMAGETDEIFICGGGEIYRQALPIADRIYLTIIHSRF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP+  P+ +  V  E      +N+  Y F + ++R
Sbjct: 122 DGDTRFPEI-PERFVEVGRET----VENAIPYSFVLYDKR 156


>UniRef50_A4IUE2 Dihydrofolate reductase n=1 Tax=Yersinia ruckeri RepID=A4IUE2_YERRU
          Length = 191

 Score =  216 bits (551), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 68/162 (41%), Positives = 101/162 (62%), Gaps = 5/162 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLI A+A +  IG +NA+PW+LP DL + K++T+ KP++MGR T++SIGRPLPGR N+
Sbjct: 27  IISLILAMADNGTIGDKNALPWHLPNDLQFLKKSTMGKPIVMGRKTYQSIGRPLPGRTNV 86

Query: 61  ILSSQPGTD--DRVTWVKSVDEAIAACG---DVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           ++S     +          +  AIAA     +V EIM++GG ++Y   LP   +LYLTH+
Sbjct: 87  VISRSLEKEALPGCLIYSDLSVAIAALKKEPEVEEIMIMGGAQIYRAALPMMDRLYLTHV 146

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
            A +EGDT  P ++      +F E H  D +N + Y FEI +
Sbjct: 147 HANIEGDTQMPPFDFSHATLIFEEKHFKDEKNRYDYTFEIWD 188


>UniRef50_UPI0001698640 dihydrofolate reductase n=1 Tax=Endoriftia persephone
           'Hot96_1+Hot96_2' RepID=UPI0001698640
          Length = 158

 Score =  215 bits (549), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 71/149 (47%), Positives = 97/149 (65%), Gaps = 1/149 (0%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67
           +A +RVIG  N MPW+LPADL  FK  T+ KP++MGR TWES+   LP R +I+++  P 
Sbjct: 1   MARNRVIGRHNRMPWHLPADLRHFKALTIGKPIVMGRKTWESLPGLLPDRPHIVVTHNPS 60

Query: 68  T-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126
              +  T V S+DEAIAA G+V EIMV+GGG  Y + LP+  ++YLT +DAE EGDT FP
Sbjct: 61  YYAEGCTLVHSIDEAIAAAGEVEEIMVVGGGAFYAEILPRVGRIYLTLVDAEFEGDTLFP 120

Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEI 155
           D +  +W     E H AD ++++ Y    
Sbjct: 121 DLDMAEWLECSRERHPADEKHTYPYSLHR 149


>UniRef50_A2U3M8 Dihydrofolate reductase n=2 Tax=Polaribacter RepID=A2U3M8_9FLAO
          Length = 164

 Score =  215 bits (548), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 60/161 (37%), Positives = 90/161 (55%), Gaps = 3/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI++IAA+A +  +G  N + W+LPADL  FK+ T    ++MGR+T+ESIGRPLP R  I
Sbjct: 1   MITIIAAIAKNNALGKNNDLIWHLPADLKRFKKVTTGHHILMGRNTFESIGRPLPNRITI 60

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL--PKAQKLYLTHIDA 117
           I++       +      SV++A+    D  +I +IGG +VYE  +    A  L +T +  
Sbjct: 61  IITKNEEYVQEGCLIANSVEQALEMAHDDDQIFIIGGAQVYEYAMKHDFADALDITLVHH 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E E D +FP+ +P  W  V  E   AD +N   Y F   ++
Sbjct: 121 EFEADVYFPEIDPTVWRRVEREDFIADEKNKFDYSFIRYKK 161


>UniRef50_A1VQZ7 Dihydrofolate reductase n=9 Tax=Bacteria RepID=A1VQZ7_POLNA
          Length = 166

 Score =  214 bits (547), Expect = 5e-55,   Method: Composition-based stats.
 Identities = 62/161 (38%), Positives = 89/161 (55%), Gaps = 7/161 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           I+LI A A + VIG  NAMPW+LP DLA FKR T   PVIMGR TW+S+    RPLPGR 
Sbjct: 6   INLIYARAANGVIGRNNAMPWHLPEDLAHFKRLTQGWPVIMGRKTWDSLPPRFRPLPGRT 65

Query: 59  NIILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           N++++ QP           S+ +A+A C    E+ VIGG ++Y    P A ++ +T I  
Sbjct: 66  NLVITRQPDWQAPGALPAASLADALAQCSQSEEVWVIGGAQIYAHAEPLADRIEVTEIAQ 125

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + +GD   P    ++W+    E H +   +   + F   E+
Sbjct: 126 DFDGDAFAPPLG-EEWQETAREAHVSS--HGLPFSFVTFEK 163


>UniRef50_Q1CZU3 Dihydrofolate reductase n=1 Tax=Myxococcus xanthus DK 1622
           RepID=Q1CZU3_MYXXD
          Length = 159

 Score =  214 bits (547), Expect = 6e-55,   Method: Composition-based stats.
 Identities = 66/160 (41%), Positives = 89/160 (55%), Gaps = 6/160 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S I A+A +RVIG  N +PW LPADLA FKR T+   ++MGR T+ESIGRPLPGR  I+
Sbjct: 3   LSAIVAMAANRVIGAGNQLPWRLPADLARFKRITMGHTLVMGRKTYESIGRPLPGRTFIV 62

Query: 62  LSSQ-PGTDDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++ Q       V    SVDEA++        E+ + GG  +Y Q + + Q++YLTHI   
Sbjct: 63  VTRQRDFAPPGVQVAHSVDEALSLAKASGDSEVFIAGGADLYAQTMDRVQRIYLTHIARN 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             GDT FPD +   W  V  + H         + F   ER
Sbjct: 123 FPGDTWFPDVDLSGWTCVEEQAHPDAE---PPHTFLTYER 159


>UniRef50_A6UB22 Dihydrofolate reductase n=18 Tax=Alphaproteobacteria
           RepID=A6UB22_SINMW
          Length = 187

 Score =  214 bits (546), Expect = 7e-55,   Method: Composition-based stats.
 Identities = 67/165 (40%), Positives = 96/165 (58%), Gaps = 7/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I ++ A+A++ VIG E  +PW LP DL  FK  T+ KPVIMGR TW +IGRPLPGR NI+
Sbjct: 14  IVIVVAVALNGVIGREGDLPWRLPTDLKRFKAQTIGKPVIMGRKTWAAIGRPLPGRPNIV 73

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++     +        S++ A+A   +        EI VIGGG +Y Q +  A  L++T 
Sbjct: 74  VTRNRAFEAPGAEVAPSLEAALAVARERAAAIGADEICVIGGGEIYRQSIGMADVLHVTE 133

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + AEV+GDT FP+ +P  +E V  E   +  ++SH+  F    RR
Sbjct: 134 VQAEVDGDTRFPEIDPAVFEKVLEEDLQSGEKDSHAMHFVTWRRR 178


>UniRef50_UPI0000E87D66 dihydrofolate reductase n=1 Tax=Methylophilales bacterium HTCC2181
           RepID=UPI0000E87D66
          Length = 161

 Score =  214 bits (546), Expect = 8e-55,   Method: Composition-based stats.
 Identities = 61/159 (38%), Positives = 96/159 (60%), Gaps = 3/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A++ + VIG+ N +PW++P DL  FK  T+  P++MGR T++SIGRPLPGRKNI+
Sbjct: 4   ISIIVAMSNNNVIGINNTLPWHIPQDLKRFKSLTMGNPIVMGRKTFDSIGRPLPGRKNIV 63

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++    +  + V  V S++  +A   D   + VIGG ++Y+ FL  A  LY+T +D++V 
Sbjct: 64  ITRNEDSIIEGVEIVNSINSLLALIKDEEHVFVIGGEQIYKIFLDHATHLYVTEVDSDVA 123

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GD HFP      W+ V  E     +++   + F    R+
Sbjct: 124 GDAHFPKLSTSQWKEVGRE--KLVSKDDLHFSFVDYIRQ 160


>UniRef50_C9BJS9 Dihydrofolate reductase n=13 Tax=Enterococcus RepID=C9BJS9_ENTFC
          Length = 175

 Score =  214 bits (546), Expect = 8e-55,   Method: Composition-based stats.
 Identities = 56/161 (34%), Positives = 89/161 (55%), Gaps = 3/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           M++ I A   + +IG E+ +PW LP DL +FK+ T    ++MGR T+E +G RPLP R+ 
Sbjct: 1   MLAAIWAQDENGLIGKEDRLPWRLPNDLKFFKQMTEANTLVMGRKTFEGMGSRPLPNRQT 60

Query: 60  IILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVI-GGGRVYEQFLPKAQKLYLTHIDA 117
           I+L+       + V  + SV++ +A   +   I  I GG  VY++FLP    LY T I  
Sbjct: 61  IVLTRDSSYKAEGVHVMHSVEDVLALEKETDGIFFIAGGSAVYQEFLPFCTILYRTVIHH 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             +GD +FP  +  DW  + +   + D +N + + FE  +R
Sbjct: 121 VFDGDAYFPPVDWSDWSLINTSQGEMDEKNRYPHQFETYQR 161


>UniRef50_A5CVJ7 Dihydrofolate reductase n=1 Tax=Candidatus Vesicomyosocius okutanii
           HA RepID=A5CVJ7_VESOH
          Length = 163

 Score =  214 bits (546), Expect = 9e-55,   Method: Composition-based stats.
 Identities = 60/158 (37%), Positives = 100/158 (63%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A+  + +IG +N++PW LPADLA+FK+ T+ K ++MGR T +SIGR LP R+NII
Sbjct: 3   LSIIVAMDDNYLIGKDNSLPWYLPADLAYFKKITIGKTILMGRKTHDSIGRSLPNRRNII 62

Query: 62  LSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S       D    V S+D A++   +  E+M++GG   Y+Q + K  +LY+T +    +
Sbjct: 63  VSKNTKFKADNCEVVSSIDVALSLANNDNELMIVGGSSFYDQIIDKVDRLYITEVKGMFD 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD +FP+++   +  +  E H  D +N ++Y F +L+R
Sbjct: 123 GDAYFPEFDRTKFIELSRESHKPDEKNFYTYNFIVLQR 160


>UniRef50_Q21NW4 Dihydrofolate reductase n=3 Tax=Bacteria RepID=Q21NW4_SACD2
          Length = 171

 Score =  214 bits (545), Expect = 9e-55,   Method: Composition-based stats.
 Identities = 62/169 (36%), Positives = 99/169 (58%), Gaps = 11/169 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + ++ A A + VIG+ N +PW + ADL  FK+ T+  P+IMGR T++SIG+PLPGR  I+
Sbjct: 3   LVIVVAAAQNGVIGINNTLPWRISADLQHFKQVTIGHPIIMGRKTYDSIGKPLPGRTTIV 62

Query: 62  LSSQ-----PGTDDRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKL 110
           ++ Q      G +D+V    S++ A+     +       E M++GG ++Y Q L +  K+
Sbjct: 63  VTRQADWQAEGYEDQVKVAYSLEGAMELAEQIAAQMGVAEAMLVGGAQLYRQALERVSKV 122

Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +LT + AE+EGD  FP+ + + W  V    + AD +N + Y F  L RR
Sbjct: 123 HLTRVHAEIEGDAWFPELDGNIWAEVQCVRYKADEKNEYDYSFVELHRR 171


>UniRef50_A3N0P3 Dihydrofolate reductase n=6 Tax=Pasteurellaceae RepID=A3N0P3_ACTP2
          Length = 162

 Score =  214 bits (545), Expect = 9e-55,   Method: Composition-based stats.
 Identities = 79/161 (49%), Positives = 106/161 (65%), Gaps = 4/161 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A  ++ VIG EN MPWNLP DLAWF++NTL KPVIMGR T+ESIGR LP R NII
Sbjct: 3   ISLIVARTLNHVIGKENQMPWNLPVDLAWFRQNTLGKPVIMGRKTYESIGRLLPKRPNII 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACG---DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LS      +     ++  +A        +  EIMVIGGG +++Q +P+A +LYLT I AE
Sbjct: 63  LSRSGFCVEGAYTAQNFAQAAELAETFANTDEIMVIGGGELFKQTIPQADRLYLTEIQAE 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +EGDT F +++  +W  V  ++ + D QN++   F ILER+
Sbjct: 123 IEGDTLF-EFDESNWTLVEEKWSEIDEQNAYRCRFMILERK 162


>UniRef50_Q5X875 Dihydrofolate reductase FolA n=6 Tax=Legionella RepID=Q5X875_LEGPA
          Length = 163

 Score =  214 bits (545), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 64/158 (40%), Positives = 89/158 (56%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAA+     +G+ N +   LPADL  FK  T+ KP+IMGR T+ESIG+PLPGR NI
Sbjct: 3   LISLIAAIDETGGLGINNQLLCYLPADLQHFKSITMGKPIIMGRKTYESIGKPLPGRLNI 62

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++S    +   V  V S+ +AI    D  E+M+IGG ++Y Q +  A +LY+T I  +  
Sbjct: 63  VISQSIQSIPGVVVVDSLGQAIKETADASEVMIIGGAKIYSQAISIANRLYITRIHHQFM 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            D  FP      W     E+   D +N +   F I ER
Sbjct: 123 ADVFFPKINELVWSCRSKEYRQHDNKNQYDMTFCIYER 160


>UniRef50_D0J2N2 Dihydrofolate reductase region n=3 Tax=Bacteria RepID=D0J2N2_COMTE
          Length = 167

 Score =  213 bits (543), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 66/167 (39%), Positives = 92/167 (55%), Gaps = 12/167 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           I LI A A + VIG +N MPW+LP D+A FK  T    VIMGR TW+S+    RPLPGR 
Sbjct: 3   IQLIYARAANGVIGKDNTMPWHLPEDMAHFKELTRGCAVIMGRKTWDSLPPRFRPLPGRS 62

Query: 59  NIILSSQPG-----TDDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYL 112
           NI+++ Q         D+V    S+ EA+    ++  ++ VIGG ++Y Q LP A  + +
Sbjct: 63  NIVVTRQADWQAEPASDQVLRAASLSEALELGRNLSQDVWVIGGAQIYAQALPLADAVEV 122

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T I  + EGD   P+   + W++V    H +   N   YCF   ERR
Sbjct: 123 TEIGRDFEGDAFAPELG-EQWQAVSRSEHVS--ANGLPYCFVRFERR 166


>UniRef50_Q5WDS2 Dihydrofolate reductase n=3 Tax=Bacillus RepID=Q5WDS2_BACSK
          Length = 162

 Score =  212 bits (542), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 51/160 (31%), Positives = 81/160 (50%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI  + A      IG +N +PW+LPADL  FKR T  + ++MGR T++S+G PLP RKN+
Sbjct: 1   MIVFVYARDAHYGIGKDNGLPWHLPADLRHFKRTTTGQTIVMGRKTFDSMGGPLPNRKNV 60

Query: 61  ILSS-QPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L+  +    +    + S+D+ +        I VIGG  ++        K  +T ID + 
Sbjct: 61  VLTRSRSFQAEGAEVIHSLDDVLQLSKQ-EAIYVIGGAEIFALLWDICDKHIVTVIDEKF 119

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E DT  P     +WE V +     D +N + + +    R+
Sbjct: 120 EADTFVPPLSEQEWELVETVPGPIDEKNRYPHEYRTYVRK 159


>UniRef50_C5CTW3 Dihydrofolate reductase n=1 Tax=Variovorax paradoxus S110
           RepID=C5CTW3_VARPS
          Length = 177

 Score =  212 bits (541), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 63/163 (38%), Positives = 94/163 (57%), Gaps = 7/163 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           I LI A A + VIG +  +PW+LP D+  FK+ T   PV+MGR TW+S+    RPLPGR+
Sbjct: 10  IHLIFARAANGVIGAKGTIPWHLPEDMVHFKQQTAGAPVVMGRKTWDSLPPRFRPLPGRR 69

Query: 59  NIILSSQPG-TDDRVTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           NI+++ Q     +    V S+ EA+A C +  VP++ +IGG ++Y +  P AQ++ +T +
Sbjct: 70  NIVVTRQDDWKAEGAWRVGSLQEALALCEESQVPDVWIIGGAQIYAEAEPLAQQVVVTEL 129

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             + EGD H P+  P  W     E H   A+   +Y F   ER
Sbjct: 130 AHDYEGDAHAPELSPSAWRETKREAH-VSAKEGLNYSFVTYER 171


>UniRef50_Q47IJ5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=Q47IJ5_DECAR
          Length = 163

 Score =  212 bits (540), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 58/162 (35%), Positives = 87/162 (53%), Gaps = 6/162 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           I LIAA+A +RVIG +N + WNLP D+A FK  T  + V+MGR TWES+    RPLPGR+
Sbjct: 4   IILIAAVAKNRVIGKDNTLIWNLPEDMAHFKALTAGQTVVMGRKTWESLPPRFRPLPGRR 63

Query: 59  NIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           N+++S Q            S++ A+        + +IGG ++Y+Q +  A +L +T +D 
Sbjct: 64  NVVISRQADYAAPGAEVANSLENALQLASTAESVFIIGGEQIYKQAMAVADRLEITDVDL 123

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E  GD  FP+    DW         +  Q+   + F    R+
Sbjct: 124 EPAGDAWFPEIAATDWSVTQKNTPPS--QSGTGFSFVTYRRK 163


>UniRef50_B3PTQ3 Dihydrofolate reductase protein n=49 Tax=Proteobacteria
           RepID=B3PTQ3_RHIE6
          Length = 172

 Score =  212 bits (540), Expect = 4e-54,   Method: Composition-based stats.
 Identities = 64/164 (39%), Positives = 103/164 (62%), Gaps = 7/164 (4%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           ++IAA+A + +IG +  MPW L +DL  FK  TL KPV+MGR T++SIG+PLPGR N+++
Sbjct: 7   TIIAAVARNGIIGRDGDMPWRLSSDLKRFKALTLGKPVVMGRKTYDSIGKPLPGRPNVVI 66

Query: 63  SSQPGTD-DRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           S Q   D   V    S+ EA+ A         V EI ++GGG++Y Q +  A ++ +TH+
Sbjct: 67  SRQAAIDHPDVAMAHSLAEAMDAAERLARETGVDEICIVGGGQIYAQAINLADRMCITHV 126

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +A+++GD  FPD +PD W++  +    A  ++S+   + + +RR
Sbjct: 127 EADLDGDASFPDIDPDLWQAAETIAVPAGEKDSYPTRYVVYKRR 170


>UniRef50_Q9RR65 Dihydrofolate reductase n=2 Tax=Deinococcus RepID=Q9RR65_DEIRA
          Length = 180

 Score =  211 bits (539), Expect = 5e-54,   Method: Composition-based stats.
 Identities = 64/160 (40%), Positives = 91/160 (56%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           I  IAA   +RVIG +  MPW+LPAD A F+  ++ KP IMGR  ++++ R PLP R NI
Sbjct: 17  IVAIAAQTENRVIGRDGGMPWHLPADFAHFRALSVGKPNIMGRKVFDTLRRKPLPERVNI 76

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L+       D      S +EA+   GD PEI +IGG  +Y  +  +  +L +T I AE+
Sbjct: 77  VLTRNENLKFDGCLIAHSPEEALQLAGDAPEIAIIGGEEIYRLYWDRLTRLEMTLIHAEL 136

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP+  P +WE     F  AD +N +   F+   RR
Sbjct: 137 DGDTFFPEIGP-EWELAQETFRPADEKNRYDLTFQTWRRR 175


>UniRef50_Q11US6 Dihydrofolate reductase n=1 Tax=Cytophaga hutchinsonii ATCC 33406
           RepID=Q11US6_CYTH3
          Length = 161

 Score =  211 bits (538), Expect = 6e-54,   Method: Composition-based stats.
 Identities = 64/162 (39%), Positives = 88/162 (54%), Gaps = 5/162 (3%)

Query: 1   MI-SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKN 59
           MI S+I A + +R IG+ N +PW+LPADL  FK  T+   +IMGR T+ESIG PLPGR +
Sbjct: 1   MIRSIIVAQSENRAIGINNTLPWHLPADLKRFKAITMGHHMIMGRKTYESIGNPLPGRTS 60

Query: 60  IILSSQPGTD-DRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+++          T   S+ EA  IA   +  E  VIGG  + ++ +    KLYLT I 
Sbjct: 61  IVVTRNKDLVFAGCTMAHSLAEAFEIAQNNNDSEAFVIGGAELIKEAINSCDKLYLTTIH 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              EGDT        DW+      H  D +N++SY F   E+
Sbjct: 121 QNFEGDTFLDAL-ASDWKETEHVVHAPDDKNAYSYSFITYEK 161


>UniRef50_Q54277 Dihydrofolate reductase n=84 Tax=Bacilli RepID=DYR_STAHA
          Length = 166

 Score =  210 bits (536), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 62/158 (39%), Positives = 87/158 (55%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A+   RVIG +N +PW + +D  + K  T    +I+GR   +SIGR LP R+NII
Sbjct: 7   ISLIVAMDKKRVIGKDNDIPWRISSDWEYVKNTTKGHAIILGRKNLQSIGRALPDRRNII 66

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+     +        S++ A   C +  E+ + GG ++Y  FLP  +K+Y+T I  E E
Sbjct: 67  LTRDKNFNFKDCEIAHSIEAAFKLCENEEEVFIFGGEQIYVMFLPYVEKMYVTKIHHEFE 126

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT FP    DDW+ V  E    D +N + Y F I ER
Sbjct: 127 GDTFFPVVNFDDWKEVSVEKGIKDEKNPYDYYFHIYER 164


>UniRef50_P04174 Dihydrofolate reductase n=33 Tax=Neisseriaceae RepID=DYR_NEIGO
          Length = 162

 Score =  210 bits (536), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 63/157 (40%), Positives = 90/157 (57%), Gaps = 3/157 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           I++IAA A +  IG  NAMPW++P D A+FK  TL KPVIMGR TWES+  +PLPGR+NI
Sbjct: 4   ITIIAACAENLCIGAGNAMPWHIPEDFAFFKVYTLGKPVIMGRKTWESLPVKPLPGRRNI 63

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S Q          V S++ A+A C    E +++GG ++Y Q +P A  L +T +D  V
Sbjct: 64  VISRQADYCAAGAETVASLEVALALCAGAEEAVIMGGAQIYGQAMPLATDLRITEVDLSV 123

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
           EGD  FP+ +   W           ++   +Y F   
Sbjct: 124 EGDAFFPEIDRTHWREAERTERRVSSK-GVAYTFVHY 159


>UniRef50_D2QWB5 Dihydrofolate reductase n=1 Tax=Pirellula staleyi DSM 6068
           RepID=D2QWB5_9PLAN
          Length = 171

 Score =  210 bits (536), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 59/159 (37%), Positives = 93/159 (58%), Gaps = 3/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLI A+  + +IG +  +PW + ADL  F+  T+   +IMGR TW+S+GR LPGR +I+
Sbjct: 11  LSLIVAMTREGLIGRDRDLPWKISADLKRFRSLTMGHTIIMGRTTWDSLGRALPGRTSIV 70

Query: 62  LSSQPG--TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           L+ +      + V    S+DEAIA      E  +IGGG +Y Q + + Q+LY+T ++A +
Sbjct: 71  LTRKADLVLPEGVLRAGSLDEAIALAAGDSEPFIIGGGEIYRQAMDRVQQLYVTWVEANI 130

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGDT FP ++P  +  +    H A    + ++ F   ER
Sbjct: 131 EGDTWFPAWDPSKFRLLEETSHPA-EGTTPAFTFTRYER 168


>UniRef50_Q5P234 Dihydrofolate reductase n=14 Tax=cellular organisms
           RepID=Q5P234_AZOSE
          Length = 167

 Score =  210 bits (535), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 65/159 (40%), Positives = 92/159 (57%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + +IAA A +  IG +N +PW L +DLA FK  T+  PV+MGR TWES+GRPLP R+N++
Sbjct: 8   VIIIAATARNGAIGRDNQLPWRLKSDLARFKETTIGHPVLMGRKTWESLGRPLPARRNLV 67

Query: 62  LSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++                + A+ A GD   + VIGG  +Y Q L  A  L LT + A+V 
Sbjct: 68  VTRDRSYSATGAEVFPDPEAALEAAGD-ETVFVIGGAELYRQLLDSADALLLTEVHADVA 126

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GD +FP ++  D++ V  E HDADA N  S+ F    R+
Sbjct: 127 GDAYFPPFDRGDFDEVRREQHDADAHNEFSFDFVEYRRK 165


>UniRef50_C6XMY9 Dihydrofolate reductase n=1 Tax=Hirschia baltica ATCC 49814
           RepID=C6XMY9_HIRBI
          Length = 182

 Score =  209 bits (534), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 67/166 (40%), Positives = 93/166 (56%), Gaps = 8/166 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           +++I A A + VIG++  +PW L  DL +FK  TL KPVIMGR TWES+  +PL GR N+
Sbjct: 15  LAMIVARAKNGVIGVDGDLPWRLKGDLKFFKSVTLGKPVIMGRKTWESLPFKPLKGRANL 74

Query: 61  ILSSQPGTDD-RVTWVKSVDEAIAA------CGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           ++S +   D        S+  AIAA        DV E+M+IGGG +Y         LY+T
Sbjct: 75  VVSRRHDFDAQGARVFPSLGVAIAAGRAIADQTDVEEVMIIGGGAIYTAAFENVDVLYVT 134

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            ++ E EGDT FP+ + D W  V    H AD  N H++    L R+
Sbjct: 135 EVNTEPEGDTFFPEIDDDVWTCVEETNHAADEDNDHAFVMRKLVRK 180


>UniRef50_C3JBM5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=C3JBM5_9PORP
          Length = 170

 Score =  209 bits (534), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 51/159 (32%), Positives = 88/159 (55%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           +S+I A+A +  IG +N + W+LP DL  FK  T    +IMG++T+ S+    LP R+NI
Sbjct: 3   LSIIVAVAANNAIGKDNDLLWHLPGDLKRFKETTTGHAIIMGKNTFHSLPNGALPNRRNI 62

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119
           ++SS     D V    ++  A+ A     E+ +IGG ++Y   LP A K+Y + ++    
Sbjct: 63  VVSSTLVPPDGVECYSTLQAALEAVAGEEEVFIIGGAQLYAASLPLADKIYFSRVEKGFP 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E DT+FP+++  +W   +   +  D +N ++    I +R
Sbjct: 123 EADTYFPEFDLTEWTPSYCTLYPEDERNEYAVTLTIYQR 161


>UniRef50_A3HTR7 Dihydrofolate reductase n=1 Tax=Algoriphagus sp. PR1
           RepID=A3HTR7_9SPHI
          Length = 166

 Score =  209 bits (534), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 58/161 (36%), Positives = 92/161 (57%), Gaps = 4/161 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAA+A + VIG  N + W +P D   FK  T    ++MGR T+ES+G+PLP R +++
Sbjct: 3   ISLIAAVAKNGVIGKGNDLVWKIPTDFKRFKAITSGNYILMGRKTFESLGKPLPNRTHLV 62

Query: 62  LSSQPGT--DDRVTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +S        +     ++V++A   C    + ++ VIGGG +Y+Q +  A +L +T +DA
Sbjct: 63  ISRNKNYKVPEGHHLFENVEDAFIYCNKLGIEKLYVIGGGEIYKQTISIADELLITEVDA 122

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              GDT+FP+ + + W+ V  E   +D  N H + F   ER
Sbjct: 123 TPVGDTYFPEIDKNTWKIVSKESFPSDEINQHPFSFINYER 163


>UniRef50_Q04F50 Dihydrofolate reductase n=2 Tax=Oenococcus oeni RepID=Q04F50_OENOB
          Length = 170

 Score =  208 bits (531), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 64/164 (39%), Positives = 94/164 (57%), Gaps = 5/164 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MI+ I A + + VIG  N +PW+LP DL +F++ T NK V+MGR T+ES G + LP R N
Sbjct: 1   MITSIWAQSKNNVIGRNNHLPWSLPDDLKFFRQETKNKAVVMGRKTYESFGSKALPKRLN 60

Query: 60  IILSSQPGT---DDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHI 115
           IIL+S       D  V  V S  EA+    +    + VIGG  VYE F+  A +L +T +
Sbjct: 61  IILTSNMDFKSNDPEVKIVHSPIEAVNTAKEQHLPLYVIGGASVYESFMNMADRLLITLV 120

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DA ++GDT  P++    +  V    H  D ++++S+ F   ER+
Sbjct: 121 DANIKGDTFAPNFSEKSFSLVSQCHHAQDKKHAYSFDFLTYERK 164


>UniRef50_B8F4S8 Dihydrofolate reductase n=5 Tax=Pasteurellaceae RepID=B8F4S8_HAEPS
          Length = 165

 Score =  208 bits (531), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 74/160 (46%), Positives = 105/160 (65%), Gaps = 4/160 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A  +++VIG +NAM W+LP DLAWF+ NTL KPVIMGR T+ESIGR LP R NII
Sbjct: 3   ISVIVARTLNKVIGKDNAMLWHLPVDLAWFRENTLGKPVIMGRKTYESIGRLLPKRPNII 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACG---DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LS      D      S+++A+       +  EIM++GGG +++Q +P A KLYLT I A 
Sbjct: 63  LSRSGFAIDGAYSAISLEQAVELAKNFANSDEIMILGGGELFKQTMPFADKLYLTEIQAN 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +EGDT F +++   W+ +  ++ + D QNS+   F IL++
Sbjct: 123 IEGDTFF-EFDETQWQQIAEKWSEIDEQNSYRCRFMILDK 161


>UniRef50_C7X688 Dihydrofolate reductase n=7 Tax=Bacteroidales RepID=C7X688_9PORP
          Length = 165

 Score =  208 bits (531), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 58/161 (36%), Positives = 84/161 (52%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           IS+IAA+A    IG    +  ++P+D+  FK  T    VIMGR T+ES+   PLP RKN+
Sbjct: 4   ISIIAAIADKSAIGKNQQLLCHMPSDMKRFKELTTGHAVIMGRKTFESLPVAPLPNRKNV 63

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L++ P          +S+  A+  C    EI +IGG  VY Q L  A K+Y+T I  E 
Sbjct: 64  VLTTMPEAGFVNCFACESMGAALDLCEKEDEIFIIGGALVYRQALRIADKMYITRIHHEF 123

Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +  + FP    D WE    E + AD +N + Y +    R+
Sbjct: 124 PDATSFFPVVNWDLWEETEREEYPADEKNPYPYTYITYVRK 164


>UniRef50_B1XTJ0 Dihydrofolate reductase n=1 Tax=Polynucleobacter necessarius subsp.
           necessarius STIR1 RepID=B1XTJ0_POLNS
          Length = 162

 Score =  208 bits (530), Expect = 5e-53,   Method: Composition-based stats.
 Identities = 66/158 (41%), Positives = 93/158 (58%), Gaps = 5/158 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A + + VIG +N MPW + ADL +FKR T+  PVIMGR TWESIGR LPGR+NI+
Sbjct: 6   ISMIVARSRNHVIGRDNQMPWKISADLQFFKRVTMGHPVIMGRKTWESIGRSLPGRRNIV 65

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S            V S+DEA+ +  + P + VIGG +++ Q   KA +LY+T ID ++E
Sbjct: 66  VSRNASYPISGGELVGSLDEALKSLNEFPRVFVIGGEQLFRQAFDKADRLYITEIDLDIE 125

Query: 121 -GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
            GDT F       W+ V        ++   ++ F  LE
Sbjct: 126 GGDTFFEVPNASAWKEVERTPG---SEGEITFSFITLE 160


>UniRef50_D1BNV5 Dihydrofolate reductase region n=4 Tax=Veillonellaceae
           RepID=D1BNV5_VEIPT
          Length = 164

 Score =  207 bits (527), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 56/161 (34%), Positives = 88/161 (54%), Gaps = 2/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M++LI A+A +RVIG +N + W+LP DL +FK  T    +IMGR T+ES+   LP R++ 
Sbjct: 1   MLALIVAVAHNRVIGKDNTLIWHLPNDLKFFKEKTTGHVIIMGRKTFESLPFLLPNREHW 60

Query: 61  ILSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +++   G D  + V    + + A  A   +    VIGG +VYE FLP    +Y+T +D E
Sbjct: 61  VITRDKGFDAPEGVKIFHNPEAAAEAARALDAAYVIGGAQVYEAFLPYVDTMYITEVDHE 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +GD  FP++  D +          D +N + + F    R+
Sbjct: 121 FDGDAFFPEFSEDAFTIESVVDGIVDEKNQYPHRFVTYRRK 161


>UniRef50_C4FSY3 Putative uncharacterized protein n=1 Tax=Catonella morbi ATCC 51271
           RepID=C4FSY3_9FIRM
          Length = 169

 Score =  205 bits (524), Expect = 3e-52,   Method: Composition-based stats.
 Identities = 59/163 (36%), Positives = 91/163 (55%), Gaps = 5/163 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           M++L+ A      IG +N +PW+LP DL +FK+ TL   ++MGR T+ES+G R LPGR +
Sbjct: 1   MLTLVYAQDQAGGIGYQNQLPWHLPNDLKFFKQVTLGHAILMGRKTFESMGCRLLPGRTS 60

Query: 60  IILSSQPGTD---DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
            +L+ Q       + +  V ++ EAI A  +  E+MVIGG  ++   LP A ++  T I 
Sbjct: 61  YVLTRQEDYKSEIEGLHRVHNL-EAIKALAEDQEVMVIGGAEIFAALLPLADRVIRTQIK 119

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           A    DT   D + D W+ V  +    D +N +++ FE   RR
Sbjct: 120 ATFPADTFVADLDQDQWQCVEIQEGLVDDKNQYAHQFEWWVRR 162


>UniRef50_B3ER85 Putative uncharacterized protein n=1 Tax=Candidatus Amoebophilus
           asiaticus 5a2 RepID=B3ER85_AMOA5
          Length = 164

 Score =  205 bits (524), Expect = 3e-52,   Method: Composition-based stats.
 Identities = 65/163 (39%), Positives = 91/163 (55%), Gaps = 4/163 (2%)

Query: 1   MI-SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKN 59
           MI S+I A AV+ VIG +  +PW++PADL  FK  T    VIMGR T+ES+   LP RK 
Sbjct: 1   MIKSIIVAKAVNHVIGNKGRLPWHMPADLKHFKELTGGHHVIMGRKTFESLPGSLPDRKI 60

Query: 60  IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           IILS       +  T V S++ A+      +  E+ + GG  VY + L    K+YLT I 
Sbjct: 61  IILSQSLNYKVEDCTVVPSLEMALEIANQANETEVFIAGGAAVYREALGIVDKIYLTVIH 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +VEGDT FP  +   W  V    H+ D +++++Y F  L +R
Sbjct: 121 TDVEGDTFFPTLKDHQWTEVSIVSHNHDIKHAYAYDFIELAKR 163


>UniRef50_Q134B2 Dihydrofolate reductase n=10 Tax=Bradyrhizobiaceae
           RepID=Q134B2_RHOPS
          Length = 179

 Score =  205 bits (524), Expect = 3e-52,   Method: Composition-based stats.
 Identities = 65/164 (39%), Positives = 91/164 (55%), Gaps = 7/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I +I A+A + VIG  NA+PW L +D   FK+ TLNKPVIMGR T++SIGRPLPGR NI+
Sbjct: 12  IVIIVAVAENGVIGEGNAIPWRLKSDQRRFKQLTLNKPVIMGRKTYQSIGRPLPGRTNIV 71

Query: 62  LSSQ-PGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++         V    S + A              E++V+GG  +Y  +LP+A  + LT 
Sbjct: 72  VTRDTHFQAAGVVVAPSFEAAERVAAGDAMRRSATEVVVVGGSEIYAHWLPRATCIELTE 131

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + A  +GDT FP  +PD WE V    H A  ++S  + +    R
Sbjct: 132 VHASPQGDTTFPAIDPDQWEEVARTRHGAGPEDSVEFSYVTYRR 175


>UniRef50_B2I6E9 Dihydrofolate reductase n=11 Tax=Xanthomonadaceae
           RepID=B2I6E9_XYLF2
          Length = 188

 Score =  205 bits (523), Expect = 4e-52,   Method: Composition-based stats.
 Identities = 72/163 (44%), Positives = 97/163 (59%), Gaps = 4/163 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++SLIAAL   R IG +N +PW+LP DL  FK  TL +PV+MGR T  S+GRPLPGR N+
Sbjct: 24  IVSLIAALDRYRAIGRDNGLPWHLPDDLKRFKALTLGRPVLMGRKTAHSLGRPLPGRTNL 83

Query: 61  ILSSQPGTD-DRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +L+         +  V S+D AI  AA      + VIGGG +Y   LP A  +YLTH+D 
Sbjct: 84  VLTRSGHVPFSEMRAVDSLDAAIVQAAAEGADTLSVIGGGELYALTLPHANAMYLTHVDV 143

Query: 118 EVEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            V G DT+FP ++  DWE    E H  D ++++ + F    RR
Sbjct: 144 AVAGADTYFPMFDAVDWEIKNREPHQGDGRHAYPFTFIDYCRR 186


>UniRef50_A1WMP6 Dihydrofolate reductase n=2 Tax=Proteobacteria RepID=A1WMP6_VEREI
          Length = 162

 Score =  205 bits (522), Expect = 4e-52,   Method: Composition-based stats.
 Identities = 56/161 (34%), Positives = 85/161 (52%), Gaps = 7/161 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           + LI A A + VIG +  +PW+LP D+A F++ T    VIMGR TW+S+    RPLPGR 
Sbjct: 3   LHLIYARAANGVIGKDGRLPWHLPQDMAHFRQLTQGCSVIMGRKTWDSLPARFRPLPGRS 62

Query: 59  NIILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           NI+++ Q     D      S+++A+A C       VIGG ++Y Q LP A  + +T I+ 
Sbjct: 63  NIVVTRQSDWHADGARRAASLEQALALCDARQTAWVIGGAQLYAQALPLADCVEVTEINQ 122

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + +GD H P     +W  +         Q+  ++ F    R
Sbjct: 123 DFDGDAHAPTLGA-EWVEIRRSRQP--DQHGLAFSFVRYAR 160


>UniRef50_D1QNC5 Dihydrofolate reductase n=1 Tax=Prevotella oris F0302
           RepID=D1QNC5_9BACT
          Length = 160

 Score =  205 bits (522), Expect = 5e-52,   Method: Composition-based stats.
 Identities = 65/161 (40%), Positives = 95/161 (59%), Gaps = 4/161 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           ++SLIAA+A +R IG +N + +++  DL  FKR T+   VIMGRHT+ES+    LP RKN
Sbjct: 2   ILSLIAAVARNRAIGYQNRLLFHIKTDLEHFKRLTMGHVVIMGRHTFESLPNGALPHRKN 61

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++S    +    T V S  EA+  C    E+ VIGG +VY++ + +A +LYLT IDA  
Sbjct: 62  IVISKSVASFHGCTRVSSFKEALDMCQTEEEVFVIGGEQVYKEAITQADRLYLTEIDALA 121

Query: 120 E-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E  D +FP  + + W  V  E H     N  ++ F + +RR
Sbjct: 122 EQADAYFP--DYNSWHLVAHEAHKKSEDNPFAFAFTVYQRR 160


>UniRef50_C6W5S3 Dihydrofolate reductase n=1 Tax=Dyadobacter fermentans DSM 18053
           RepID=C6W5S3_DYAFD
          Length = 183

 Score =  204 bits (521), Expect = 5e-52,   Method: Composition-based stats.
 Identities = 62/161 (38%), Positives = 89/161 (55%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A A +  IG +N + W L  DL  FK+ TL  P+IMGR T+ESIG+PLPGR +I+
Sbjct: 20  ISIIVAAAENGAIGRDNQLLWRLSDDLKRFKQLTLGHPMIMGRKTFESIGKPLPGRTSIV 79

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D V  V S+DEA+      D  E+ ++GGG +YEQ    A  +YLT +   
Sbjct: 80  ITRNANFAFDGVVVVHSLDEALEKAKEIDSQEVCIVGGGEIYEQSQAIATHIYLTKVHTS 139

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           V GDT F   EP+ W       H+ D ++   + F    ++
Sbjct: 140 VVGDTFFSIREPEAWTETERISHEPDERHIFPFEFINYIKK 180


>UniRef50_C6W102 Dihydrofolate reductase n=1 Tax=Dyadobacter fermentans DSM 18053
           RepID=C6W102_DYAFD
          Length = 167

 Score =  204 bits (521), Expect = 6e-52,   Method: Composition-based stats.
 Identities = 60/160 (37%), Positives = 102/160 (63%), Gaps = 2/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+IAA++ + VIG+ N++PW+LP + A F++ T  K  IMGR ++E+        +N+I
Sbjct: 7   LSIIAAMSENHVIGLNNSLPWHLPDEWAHFRKVTAGKAFIMGRKSFEAPDALHSEYRNVI 66

Query: 62  LSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S+P    + RV + + +  AIA   D  ++ V+GG  V+EQ LP A ++YLT + A+V
Sbjct: 67  ITSRPPAQAEPRVEYARDISGAIALLSDETDVFVLGGASVFEQMLPLADRMYLTIVHAQV 126

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD  FP ++ DDW+   SEFH AD  +++++   +  R+
Sbjct: 127 EGDAFFPAFDSDDWQLADSEFHGADDDHAYAFSMNLYIRK 166


>UniRef50_C0XLT5 Dihydrofolate reductase n=3 Tax=Lactobacillus RepID=C0XLT5_LACHI
          Length = 162

 Score =  204 bits (521), Expect = 6e-52,   Method: Composition-based stats.
 Identities = 58/160 (36%), Positives = 86/160 (53%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS I A   + +IG    +PW+LP D+A+FK+ T+  P+I G  T+ S  RPLPGR+NI
Sbjct: 1   MISYIWAEDENGLIGASGNLPWHLPDDMAFFKKTTMGHPIISGARTFRSYNRPLPGRQNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +LS      D V  + SV++        P+    V GG  ++ Q L K  +LY T I  +
Sbjct: 61  VLSRHGDFPDGVLVISSVEQLCELVDKNPKENYFVTGGANLFGQLLDKVDRLYRTKIHHQ 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             GDT+ P+ +   +  V S     D +N + + FE+ ER
Sbjct: 121 FTGDTYMPEIKYAQFNQVTSIDGIVDERNRYPHTFEVFER 160


>UniRef50_A6L1Q7 Dihydrofolate reductase n=34 Tax=Bacteroidales RepID=A6L1Q7_BACV8
          Length = 164

 Score =  204 bits (519), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 57/160 (35%), Positives = 91/160 (56%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           IS+I A+A +  IG EN + + LP DL  FK  T    +IMGR T+ES+ +  LP R+NI
Sbjct: 3   ISIIVAIARNHGIGFENKLLYWLPNDLKRFKALTTGHTIIMGRKTFESLPKGALPNRRNI 62

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI-DAE 118
           +LS + G          +++ A++ C +  EI +IGG  +Y++ +  AQ+LY+T I D  
Sbjct: 63  VLSRREGAVFAGAECFPALEIALSHCKEEEEIFIIGGASLYKEAMHIAQQLYITFIDDTS 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            E D +FP+ + ++W+    E H  D ++ + Y F    R
Sbjct: 123 KEADAYFPEIKKEEWKETGREDHPTDEKHLYPYSFINYSR 162


>UniRef50_A4BS77 Dihydrofolate reductase n=1 Tax=Nitrococcus mobilis Nb-231
           RepID=A4BS77_9GAMM
          Length = 162

 Score =  203 bits (518), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 61/153 (39%), Positives = 88/153 (57%), Gaps = 1/153 (0%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67
           +A +RVIG  + +PW LPAD+  F   T  KP++MGR   ++IGR LPGR NI+LS  P 
Sbjct: 1   MAENRVIGRAHGLPWRLPADMRHFVALTRGKPIVMGRRCHDTIGRALPGRHNIVLSRNPA 60

Query: 68  TD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126
                   V  ++ A+A      EIM+IGG ++Y  FL +A ++YLT +   VEGD  FP
Sbjct: 61  HRVPGCMLVHDLEAALAVAAGASEIMIIGGEQIYRLFLARADRIYLTLVHGRVEGDAFFP 120

Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
             +  +W+    +   ADA N+++  F  L RR
Sbjct: 121 HLDAAEWQESARQSRLADADNAYALTFLTLLRR 153


>UniRef50_D0XKH5 Dihydrofolate reductase n=1 Tax=Brevundimonas subvibrioides ATCC
           15264 RepID=D0XKH5_9CAUL
          Length = 175

 Score =  203 bits (517), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 66/169 (39%), Positives = 98/169 (57%), Gaps = 12/169 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           I+L+ A A + VIG +  +PW L +DL  FK+ TL KP IMGR TWES+  RPLPGR N+
Sbjct: 6   IALVVARARNGVIGRDGDLPWKLRSDLQRFKQITLGKPCIMGRSTWESLPLRPLPGRLNL 65

Query: 61  ILSSQPGTDD-----RVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQK 109
           +LS     ++           ++ +AI           + EI VIGG  ++E  LP+A++
Sbjct: 66  VLSRDLSYEERGKAKGAVVCSNLADAIDMARETAEDDGIDEICVIGGTALFEAALPRAKR 125

Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           LY+T ++AE EGD  FP ++   +    +E HDA  ++ H + F IL+R
Sbjct: 126 LYITEVEAEPEGDALFPAFDESLFAETLNERHDAGEKDDHPFVFRILDR 174


>UniRef50_B2SDZ8 Dihydrofolate reductase n=19 Tax=Francisella RepID=B2SDZ8_FRATM
          Length = 180

 Score =  202 bits (516), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 61/162 (37%), Positives = 92/162 (56%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLI A   +  IG EN + W L  DL  FK+ T N  ++MGR T+ESIGRPLP RKNI
Sbjct: 15  MISLIVAYDKNFGIGKENTLAWKLSEDLKNFKKITENNYIVMGRKTFESIGRPLPNRKNI 74

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           IL+       D+   + S  + +      P  EI +IGG ++Y++FL  A +LY+T +DA
Sbjct: 75  ILTRDKDYKQDKCLIINSTQDILNFAESKPHYEIFIIGGAQIYKEFLKYADRLYITEVDA 134

Query: 118 EV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E+ + D  FP ++   ++ +  +    D +N   + F + E+
Sbjct: 135 EMTDLDAFFPQWDKSKYKRIGHKQFKKDDKNEFDFTFSVFEK 176


>UniRef50_C1IBP0 Dihydrofolate reductase n=1 Tax=Clostridium sp. 7_2_43FAA
           RepID=C1IBP0_9CLOT
          Length = 161

 Score =  202 bits (516), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 58/159 (36%), Positives = 89/159 (55%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MISLI A+  +  IG +N +  ++  DL +FKR T    ++MG +T+ S+  RPLP R+N
Sbjct: 1   MISLIVAMDKNNGIGNKNKLLAHISEDLRYFKRVTDGNTIVMGYNTYMSLPKRPLPNRRN 60

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I+L+++    +    V S++E +       E  + GG  +Y Q LP A KLY+THI  E 
Sbjct: 61  IVLTTKDIKLEGAVVVNSIEELLKLLNTEEETFICGGSSIYNQMLPYADKLYITHIFDEF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E DT+FP+   D+WE   S  H  +  + H + F I  +
Sbjct: 121 EADTYFPEI-TDEWEISESFCHKENINHKHPHIFTIYTK 158


>UniRef50_A1TM51 Dihydrofolate reductase n=4 Tax=cellular organisms
           RepID=A1TM51_ACIAC
          Length = 165

 Score =  202 bits (516), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 60/164 (36%), Positives = 86/164 (52%), Gaps = 7/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           + LI A A +  IG+ NAMPW+LP DLA FK+ TL   V+MGR TW+S+    RPLPGR 
Sbjct: 3   LRLIYARAANGGIGLHNAMPWHLPEDLAHFKQLTLGATVVMGRKTWDSLPARFRPLPGRT 62

Query: 59  NIILSSQPGTD-DRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           NI+++ Q G   D      S+++A+         + V+GG ++Y Q LP A  + +T I 
Sbjct: 63  NIVVTRQAGWHADGALSASSLEQAVELARPHGDTVWVMGGAQIYAQALPMADGVEVTEIH 122

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQN-SHSYCFEILERR 159
            + E D   P   P +WE          A + +  + F    RR
Sbjct: 123 RDFEADAFAPVLGP-EWEETARTPVQTSAGSAALPFSFVSYRRR 165


>UniRef50_C8X9J8 Dihydrofolate reductase n=1 Tax=Nakamurella multipartita DSM 44233
           RepID=C8X9J8_NAKMY
          Length = 292

 Score =  202 bits (515), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 65/160 (40%), Positives = 90/160 (56%), Gaps = 10/160 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + L+AA+A + VIG    MPW++PADL  FKR T+  P++MGR T+ES+G  LPGR++I+
Sbjct: 8   VVLVAAVARNGVIGAAGTMPWHIPADLKRFKRLTMGHPMVMGRKTFESMG-LLPGRRSIV 66

Query: 62  LSSQP-GTDDRVTWVKSVDEAIAA-CGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++  P           S+D AIA      P +MV+GGG +Y Q LP+A +L +TH+D   
Sbjct: 67  ITRDPHWRAPGAEVADSLDRAIALGAQTDPVVMVVGGGEIYAQALPRADRLEITHLDLSA 126

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GDT FP  +P  W     E  D        Y F    RR
Sbjct: 127 PGDTVFPAIDPALWAVTDREEADG-------YAFVTYRRR 159


>UniRef50_B2TR57 Dihydrofolate reductase n=10 Tax=Clostridium RepID=B2TR57_CLOBB
          Length = 164

 Score =  201 bits (513), Expect = 6e-51,   Method: Composition-based stats.
 Identities = 58/162 (35%), Positives = 91/162 (56%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M+S+I A+A + VIG +N + W++  DL  FK  T  K ++MGR T+ES+   LP RK+I
Sbjct: 1   MLSIIVAIAKNNVIGNDNKLIWHISEDLKRFKEITSGKTIVMGRKTFESLPGVLPNRKHI 60

Query: 61  ILSSQPGT---DDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           IL+         + V  +   DE +    +   E+ +IGGG +Y+Q LP + KLYLT I+
Sbjct: 61  ILTRDKNFKVNSECVEIIYDFDELLNKYKNSDDEVFIIGGGEIYKQLLPYSNKLYLTKIN 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            + +GDT+FP    +D++  +      D ++   Y F  L R
Sbjct: 121 KDFDGDTYFPQINYNDFKIDYESDVITDEKSGLEYKFINLSR 162


>UniRef50_B6INW3 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria
           RepID=B6INW3_RHOCS
          Length = 190

 Score =  201 bits (513), Expect = 6e-51,   Method: Composition-based stats.
 Identities = 68/166 (40%), Positives = 92/166 (55%), Gaps = 8/166 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           + L+AA+A + VIG  N +PW LP DL +FKR T+ KPV+MGR TWESIG +PLPGR NI
Sbjct: 24  LVLVAAVARNGVIGRGNTLPWRLPGDLRFFKRTTMGKPVVMGRRTWESIGAKPLPGRCNI 83

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +L+   G   +          AIA           PE+ VIGG  ++ + L  A +LYLT
Sbjct: 84  VLTRDTGFAPEGAIVCHGFLGAIAEARSVAARTGAPEVCVIGGESLFAEALRMADRLYLT 143

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + AE  GD  FP ++   W     E  DA   +S +Y    L+R+
Sbjct: 144 EVLAEPAGDVLFPPFDRGAWMQTELERADAAGPDSPAYRILRLDRK 189


>UniRef50_Q0C500 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria
           RepID=Q0C500_HYPNA
          Length = 176

 Score =  200 bits (509), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 71/165 (43%), Positives = 91/165 (55%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           + LI A A +R+IG   A+PW L  D+A+FK  T+  PVIMGR TWES   RPLPGR+NI
Sbjct: 7   LCLIVAQARNRIIGAAGALPWRLKDDMAFFKATTMGAPVIMGRKTWESFPKRPLPGRENI 66

Query: 61  ILSSQPGTDDRVTWVKS-------VDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +L+     D     V S          AIAA     E  VIGG  +Y   LP A ++YLT
Sbjct: 67  VLTRDWDYDAAEARVYSSFPAAMNAARAIAAREGKDEAFVIGGAEIYALALPFADRIYLT 126

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            +DAE+EGDT FP+ +   W S     H A   N H++    L+R
Sbjct: 127 EVDAEIEGDTLFPELDLRQWRSDEIATHPAGEGNDHAFIIRRLDR 171


>UniRef50_C4L1C8 Dihydrofolate reductase region n=2 Tax=Exiguobacterium
           RepID=C4L1C8_EXISA
          Length = 162

 Score =  199 bits (507), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 55/159 (34%), Positives = 89/159 (55%), Gaps = 3/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS + A   +R IG +N + W LP DL  FK  T    V+MGR T+ESIG+ LP R+NI
Sbjct: 1   MISHVVAYGQNREIGKDNDLLWRLPDDLKHFKAITSGGTVVMGRKTFESIGKALPNRRNI 60

Query: 61  ILSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++S    + D+V     +D  +A      E  VIGG  +YEQ +P   ++Y T + A  
Sbjct: 61  VVTSDVSFSADQVEVWHDLDR-LAEMSQQEEWFVIGGAMLYEQTMPMTSRIYATEVAASF 119

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E DT++P+ +  +W    +  H  D  +++++ F+  ++
Sbjct: 120 EADTYYPE-QTGEWSVTSTIDHPQDETHAYAFSFKQYDK 157


>UniRef50_Q6MID1 FolA protein n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MID1_BDEBA
          Length = 169

 Score =  199 bits (506), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 51/172 (29%), Positives = 89/172 (51%), Gaps = 17/172 (9%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59
           +++ + A + +RVIG +  +PW+LP D+ +F+  T    +IMGR T++S  GR LP R +
Sbjct: 2   ILTHVVACSQNRVIGAQGGLPWSLPEDMKFFRETTKGHIMIMGRKTFDSFNGRALPNRYH 61

Query: 60  IILSSQPGTD-------DRVTWVKSVDEAIAACGDV-----PEIMVIGGGRVYEQFLPKA 107
           I+++  P            V +V S++EA+     +      E+ +IGGG +Y+Q +P  
Sbjct: 62  IVVTRDPSKQSFNSTESSPVVFVASIEEAVKHAEPLTAKWGDEVFIIGGGEIYKQAMPIT 121

Query: 108 QKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            K+YLT I  E  GDT++P+ +   +          D +    + F    R+
Sbjct: 122 DKIYLTLIHREFPGDTYYPEIDEKVFTQTER----RDIETPIPFSFLTYLRK 169


>UniRef50_Q5HPB1 Dihydrofolate reductase n=24 Tax=Bacilli RepID=DYR_STAEQ
          Length = 161

 Score =  198 bits (505), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 57/159 (35%), Positives = 90/159 (56%), Gaps = 4/159 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A    RVIG +N +PW+LP DL   K+ T    ++MGR T+ SIG+PLP R+N++
Sbjct: 3   LSIIVAHDKQRVIGYQNQLPWHLPNDLKHVKQLTTGNTLVMGRKTFNSIGKPLPNRRNVV 62

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L++Q     + V  + S+DE     G    + + GG  ++E  + +   +Y+T ID + +
Sbjct: 63  LTNQASFHHEGVDVINSLDEIKELSG---HVFIFGGQTLFEAMIDQVDDMYITVIDGKFQ 119

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FP Y  ++WE   S     D +N+  + F  L RR
Sbjct: 120 GDTFFPPYTFENWEVESSVEGQLDEKNTIPHTFLHLVRR 158


>UniRef50_A7IF75 Dihydrofolate reductase n=3 Tax=Rhizobiales RepID=A7IF75_XANP2
          Length = 178

 Score =  198 bits (505), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 55/165 (33%), Positives = 93/165 (56%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++L+ A++ + VIG +  +PW LP+DL  F+  T  KP++MGR T+ESIGRPLPGR +++
Sbjct: 11  LALVVAVSQNGVIGTDGGLPWRLPSDLKRFRALTWGKPLLMGRRTYESIGRPLPGRTSVV 70

Query: 62  LSSQPGT--DDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +S+ P     + V    S+++ +    +        EIMVIGG R++   LP A+ L+LT
Sbjct: 71  VSTDPAFTVPEGVLKGASLEDGLRLADEAADAMGADEIMVIGGARLFHDTLPLARTLHLT 130

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            + A  +GD  FP ++   W  +  +      ++  ++    L R
Sbjct: 131 QVHAAPDGDVFFPAFDEAQWREIARDGPIQGEKDEAAFTALTLVR 175


>UniRef50_Q1LSS4 Dihydrofolate reductase n=1 Tax=Baumannia cicadellinicola str. Hc
           (Homalodisca coagulata) RepID=Q1LSS4_BAUCH
          Length = 165

 Score =  198 bits (505), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 81/160 (50%), Positives = 112/160 (70%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAA+ VDR+IG++N MPW+L  DL WFK++T NKPVIMGR T+++I +PL GR NI
Sbjct: 2   IISLIAAMTVDRIIGIKNTMPWHLYDDLIWFKKHTNNKPVIMGRKTFDAIKKPLSGRLNI 61

Query: 61  ILSSQ--PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +LS    P  D  + WV +  +A+ A G+V E+MVIGG ++Y  F+ +A +LYLTHID  
Sbjct: 62  VLSRNFIPSRDQDIIWVDNPIKALIAAGNVTEVMVIGGAQIYNIFILQAHRLYLTHIDIN 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           ++GDT FP Y  + W   F ++H+   +N   Y FEILER
Sbjct: 122 IKGDTWFPHYHTNQWRVTFRKYHNDQEKNLPRYYFEILER 161


>UniRef50_UPI00017452A7 Dihydrofolate reductase n=1 Tax=Verrucomicrobium spinosum DSM 4136
           RepID=UPI00017452A7
          Length = 167

 Score =  197 bits (503), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 59/161 (36%), Positives = 83/161 (51%), Gaps = 11/161 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGR 57
           +  IAA+A +RVIG +  +PW+LP DL +FK+ T   PV+MGR T+ESI    G+PLP R
Sbjct: 11  LIAIAAMASNRVIGRDGTLPWHLPEDLKFFKKTTAGHPVLMGRKTFESIVAALGKPLPNR 70

Query: 58  KNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +NI+LSS     + V  +  +            + +IGG ++YE  LP   +L LT ID 
Sbjct: 71  RNIVLSSTLAPQEGVEVIPHLASLSQLSALTSPVYLIGGAQLYEALLPVCDELLLTWIDQ 130

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             EGD  FP +E  D+       H         + F    R
Sbjct: 131 PYEGDAFFPAFE-GDFSLREVLGHGEG------FEFRRYVR 164


>UniRef50_A8YUW1 Dihydrofolate reductase n=12 Tax=Lactobacillus RepID=A8YUW1_LACH4
          Length = 172

 Score =  197 bits (503), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 56/167 (33%), Positives = 89/167 (53%), Gaps = 8/167 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI  + A      IG++  +PW LPAD+A FK  T+  P+IMGR T+ S+ R LP RK+I
Sbjct: 1   MIEFVWAEDQKHQIGLDGHLPWRLPADMAHFKEKTIGHPIIMGRKTFMSLPRLLPQRKHI 60

Query: 61  ILSSQPGT------DDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYL 112
           +L+           +D+VT + S+ E      +    ++  +GG  +++  L +   L  
Sbjct: 61  VLTHDQDLKKKYQDNDQVTIINSIAELGDYIQNHQGEKLCTVGGVSIFKALLDQVDVLEK 120

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T IDA  E DT  P+ + D ++ V  E H+AD +N + Y F   +R+
Sbjct: 121 TEIDATFEADTVMPEIDYDQFKLVKKEHHEADEKNKYPYTFFTYQRK 167


>UniRef50_Q2W7P5 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q2W7P5_MAGSA
          Length = 175

 Score =  197 bits (503), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 73/162 (45%), Positives = 99/162 (61%), Gaps = 9/162 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A+A + VIG +NA+PW++P DL WFK NTL KPVIMGR TWESIGRPLP R NI+
Sbjct: 17  VALIVAVAANGVIGKDNALPWHIPEDLKWFKENTLGKPVIMGRKTWESIGRPLPKRPNIV 76

Query: 62  LSSQPGT-DDRVTWVKSVD----EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++ Q G   +      S+D     A     +  E+MVIGG  ++ + LP A++LYLT I 
Sbjct: 77  VTRQTGWRAEGAHTAHSLDEALALAARLAPEAAELMVIGGNSLFAEALPGARRLYLTEIA 136

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              EGDT FP +E   W  V    ++ D     ++ F IL+R
Sbjct: 137 RAYEGDTMFPAFERGLWHEVSRRRNEGDP----AFDFVILDR 174


>UniRef50_Q0AN20 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria
           RepID=Q0AN20_MARMM
          Length = 173

 Score =  197 bits (501), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 60/165 (36%), Positives = 92/165 (55%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           + L+ A  ++ VIG++  +PW L +DL  FK  T  KP+IMGR TWES+  RPLPGR NI
Sbjct: 8   LVLVVARGMNGVIGVDGDLPWRLSSDLRNFKAITSGKPIIMGRKTWESLPRRPLPGRLNI 67

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAA------CGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++ Q G   +       + EA+ A         V E+ VIGG ++Y   L +A +LYLT
Sbjct: 68  VVTRQDGYVAEGGHVAGDLGEAMDAAFMRADADGVDEVCVIGGAQIYAATLERADRLYLT 127

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            ++A  EG+T  P+ +   W     E + A   + H++   +L+R
Sbjct: 128 EVEAAPEGETCLPEIDEALWRETRRELYPAGPGDDHAFMLRVLDR 172


>UniRef50_Q1WU16 Dihydrofolate reductase n=5 Tax=Lactobacillus RepID=Q1WU16_LACS1
          Length = 167

 Score =  195 bits (497), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 56/167 (33%), Positives = 87/167 (52%), Gaps = 8/167 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS + A      IG +  +PW LPADLA FK  T+  P++MG+ T++S    LP R++I
Sbjct: 1   MISFVWAEDQKHQIGYKGHLPWRLPADLAHFKEVTMGHPMVMGKKTFDSFPGLLPRRQHI 60

Query: 61  ILSSQPGTDDR------VTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYL 112
           +L+     +++      V  + S+DE  +   +    E+ VIGG  ++   L K  KLY 
Sbjct: 61  VLTHDTNLEEKYKDNPQVEIMNSIDELTSWLDENQFQEVSVIGGAMLFNLLLNKVDKLYK 120

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T I +E  GDT  P    D+++ V  +    D +N + Y F   ER+
Sbjct: 121 TEILSEFNGDTVMPTINYDEFKLVSKKIGKVDEKNKYPYVFLEYERK 167


>UniRef50_C8NE93 Dihydrofolate reductase n=24 Tax=Lactobacillales RepID=C8NE93_9LACT
          Length = 169

 Score =  195 bits (497), Expect = 4e-49,   Method: Composition-based stats.
 Identities = 56/162 (34%), Positives = 87/162 (53%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           M+  I A     ++G +  +PW LP DL +FK  T+ + ++MGR T+E +G R LPGR+ 
Sbjct: 1   MLIYIWAQDERGLVGKDGTLPWRLPNDLKFFKEVTMGQTILMGRKTFEGMGSRLLPGRQT 60

Query: 60  IILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           IIL++           V +++E I       +I V GG +VY       + LY T I A 
Sbjct: 61  IILTTSSDYIVPGAEVVTNIEE-IVEDSRHEDIYVCGGAQVYNLLKNHVELLYCTRIHAS 119

Query: 119 VEGDTHFP-DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD++FP ++   D+  V S   + D +N + + FEI ER+
Sbjct: 120 FEGDSYFPTEFPWHDFIKVKSLEGEIDEKNLYPHTFEIYERK 161


>UniRef50_Q03S94 Dihydrofolate reductase n=4 Tax=Lactobacillus RepID=Q03S94_LACBA
          Length = 163

 Score =  195 bits (496), Expect = 4e-49,   Method: Composition-based stats.
 Identities = 54/162 (33%), Positives = 86/162 (53%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M+  + A +  RVIG+   +PW+LPAD+ +FK  T    ++ G  T+ S  RPLP RKNI
Sbjct: 1   MLIFLWAESQGRVIGLHGGLPWHLPADMHYFKTVTTGHTIVAGSKTFASFPRPLPNRKNI 60

Query: 61  ILSSQPGT--DDRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++S QP T   + V+ + S+    A AA     +I V+GG +++   L     LY T ID
Sbjct: 61  VVSHQPATAFPENVSVLHSLPAVRAYAAARPQEKIFVVGGAQLFAGLLDDVDFLYRTRID 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           A  +GDT  P  +   +  +  +    + +N + + FE  +R
Sbjct: 121 AGFDGDTWMPVIDYSQFTLIDQQPGIRNEKNPYDFVFEQYQR 162


>UniRef50_B9ECC1 Putative uncharacterized protein n=1 Tax=Macrococcus caseolyticus
           JCSC5402 RepID=B9ECC1_MACCJ
          Length = 164

 Score =  195 bits (496), Expect = 5e-49,   Method: Composition-based stats.
 Identities = 60/160 (37%), Positives = 93/160 (58%), Gaps = 5/160 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAA++ + VIG +  +PW +P +   FK  T+ K VIMGR T+ESIG+PLP RK I
Sbjct: 2   IISLIAAISSNYVIGKDKDIPWKIPGEQVRFKDLTMGKSVIMGRKTFESIGQPLPNRKTI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I+S     + +    V+S++ A        EI + GGG +Y++ LP A ++YLT I+ E 
Sbjct: 62  IISKSKDINYNNCLTVESLERAFNLLQQEDEIFIAGGGEIYKESLPFADRIYLTIIEKEY 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EG+  FP +  D++E  + +      +    Y +   ER+
Sbjct: 122 EGNIFFPMFNKDEFEITYQQK----VEGFIPYTYFTYERK 157


>UniRef50_Q3BX85 Dihydrofolate reductase n=6 Tax=Xanthomonas RepID=Q3BX85_XANC5
          Length = 164

 Score =  195 bits (496), Expect = 5e-49,   Method: Composition-based stats.
 Identities = 68/162 (41%), Positives = 95/162 (58%), Gaps = 4/162 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A   +  IG +N +PW LP DL  FK  TL KP++MGR T +S+GR LPGR N++
Sbjct: 3   LTLIVAFDRNNAIGRDNELPWKLPDDLKRFKALTLGKPILMGRKTAQSLGRALPGRLNLV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           L+       D +  V SV++AI         E+ VIGGG VY   + +A  L +T +D  
Sbjct: 63  LTRSGQVPFDGMQAVASVEQAIERAVQEGAQELCVIGGGEVYRLTMERADLLAVTEVDTA 122

Query: 119 VEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           V+G DTHFP  +P  W     E H ADA+++H++ F   ERR
Sbjct: 123 VDGADTHFPPIDPAVWSPARRELHAADARHAHAFSFVDYERR 164


>UniRef50_A0PY39 Dihydrofolate reductase n=3 Tax=Clostridium RepID=A0PY39_CLONN
          Length = 170

 Score =  194 bits (495), Expect = 6e-49,   Method: Composition-based stats.
 Identities = 60/163 (36%), Positives = 92/163 (56%), Gaps = 5/163 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL--NKPVIMGRHTWESIGRPLPGRK 58
           M+S++ A+  + VIG ++++PW+LP DL +FK+ TL  +K +IMGR T++S+   LPGRK
Sbjct: 1   MLSIVVAIGKNNVIGKDHSLPWHLPNDLKYFKKVTLTESKTMIMGRKTFQSLKALLPGRK 60

Query: 59  NIILSSQPGT---DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           +IIL+        D  V  +  +D       D  E  VIGGG ++   LP  +K+Y+T I
Sbjct: 61  HIILTKNKNFNMKDSNVEIINKIDMLKPIINDKKEYFVIGGGEIFSLLLPYTEKIYMTKI 120

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
                GDT FP+    DW +        D +N +++ F IL R
Sbjct: 121 HHNFIGDTFFPNINRYDWNTTKEIQGITDEKNVYNHTFLILNR 163


>UniRef50_B6YRF0 Dihydrofolate reductase n=1 Tax=Candidatus Azobacteroides
           pseudotrichonymphae genomovar. CFP2 RepID=B6YRF0_AZOPC
          Length = 164

 Score =  194 bits (495), Expect = 6e-49,   Method: Composition-based stats.
 Identities = 56/160 (35%), Positives = 83/160 (51%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           +S+IA+L  +  IG EN +   LPADL  F++ TL   +IMGR T++S+    LP R+NI
Sbjct: 3   LSIIASLGRNNEIGKENRLLCYLPADLKHFRKITLGHSIIMGRKTFDSLPNGILPDRENI 62

Query: 61  ILSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I+S              S+D A++   +  E+ +IGG ++Y+Q LP    LYLT + A  
Sbjct: 63  IISRNGSLAIKNARVYTSLDFALSKLMNEEEVFIIGGAQIYQQTLPIVNNLYLTKVYATF 122

Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            E D  FP     +W     E   A+ +N +   F   ER
Sbjct: 123 PEADVFFPLINYSEWHETEQEKIPANTKNPYPISFTKYER 162


>UniRef50_C1SJK6 Dihydrofolate reductase n=1 Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SJK6_9BACT
          Length = 156

 Score =  194 bits (494), Expect = 8e-49,   Method: Composition-based stats.
 Identities = 53/157 (33%), Positives = 84/157 (53%), Gaps = 8/157 (5%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           +LI A+  DRVIG  N MPW+LP DL  FK  T    + MGR T+ESIGRPLP R+N ++
Sbjct: 4   ALIVAMTKDRVIGKNNDMPWHLPEDLKLFKAKTTGHIIAMGRKTYESIGRPLPNRENFVI 63

Query: 63  SSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           +      D      SV E I A  +  + +  IGGG++Y   +    ++++++I    +G
Sbjct: 64  TRSGKEYDGCRVFGSVQECIKAAEEYDKTLFFIGGGQIYSDAVDMVDEMHISYIKENYDG 123

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           DT FP+++   W+   +E +         + ++   R
Sbjct: 124 DTFFPEFDESRWKVTETEEYG-------DFIYKKFVR 153


>UniRef50_A6GQA5 Dihydrofolate reductase n=1 Tax=Limnobacter sp. MED105
           RepID=A6GQA5_9BURK
          Length = 188

 Score =  194 bits (493), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 57/183 (31%), Positives = 93/183 (50%), Gaps = 26/183 (14%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S++AA+A + +IG+ N++PW+LP DLA+FK+ TL  PV+MGR T+ESI RPLPGR N++
Sbjct: 3   VSIVAAVAENGIIGINNSLPWHLPEDLAFFKQTTLGCPVLMGRKTYESINRPLPGRLNVV 62

Query: 62  LSSQPGTDD------------------------RVTWVKSVDEAIAACGDVPEIMVIGGG 97
           LSS                              ++    ++ +A+       ++ +IGG 
Sbjct: 63  LSSNSDWKPAPGKDGTPRSVITHPAALPEGSATQIATATNLPDALNWLSSFEQVFLIGGS 122

Query: 98  RVYEQFLPK--AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEI 155
            +YEQ L +    +L LT I    EGD  FP ++   +  V    + A  + +  + F  
Sbjct: 123 NLYEQALAQGLVDELILTEIHQSFEGDASFPQWDRQQFREVDRITNTATPERAWGFDFVK 182

Query: 156 LER 158
             +
Sbjct: 183 YAK 185


>UniRef50_B9LR90 Dihydrofolate reductase region n=2 Tax=Halobacteriaceae
           RepID=B9LR90_HALLT
          Length = 194

 Score =  194 bits (493), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 66/171 (38%), Positives = 96/171 (56%), Gaps = 14/171 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWES----IGRPLPGR 57
           + L+AA+A +RVIG +  MPW+ PADLA FKR T   PVI+GR T+ES    IG PLP R
Sbjct: 21  LVLVAAVAENRVIGDDGGMPWHYPADLARFKRLTTGHPVIVGRATYESIADRIGGPLPDR 80

Query: 58  KNIIL-SSQPGTDDRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKL 110
            +++L +      +       +DEA+   G       V ++ VIGG  VYEQFL +A ++
Sbjct: 81  TSVVLTTRDLDLPEGAVVANDLDEAVDLAGADAADRGVDDVYVIGGATVYEQFLDRADRM 140

Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQ---NSHSYCFEILER 158
            LT +  + +GDT FPD++ ++W     E   AD +    + +  F   ER
Sbjct: 141 VLTEVPEQPDGDTRFPDWDDEEWVETEREVVGADGERGGEADALAFVTYER 191


>UniRef50_A0Z2N0 Dihydrofolate reductase n=2 Tax=unclassified Gammaproteobacteria
           (miscellaneous) RepID=A0Z2N0_9GAMM
          Length = 184

 Score =  193 bits (492), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 59/164 (35%), Positives = 88/164 (53%), Gaps = 7/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + L+ A++ + VIG  NA+PW+LP DL  FK+ T+  P++MGR T+ES+GRPLPGR N++
Sbjct: 13  VVLVLAVSENGVIGRGNALPWDLPDDLQHFKKATMGCPILMGRKTFESVGRPLPGRTNLV 72

Query: 62  LSSQPGTD-DRVTWVKSVDE------AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           L+         VT   SVD+      A A       + V+GG  +Y   LP+A ++ LT 
Sbjct: 73  LTRDSTWQAPGVTIFSSVDKALALAEAQALIDGASAVCVVGGAEIYRLCLPRADRILLTL 132

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +  +V GD  F     + W+    E     A+NSH +      R
Sbjct: 133 VHGDVSGDATFDLSVLETWQEQRREHFPKGARNSHDFSVVEFVR 176


>UniRef50_Q03F97 Dihydrofolate reductase n=2 Tax=Pediococcus RepID=Q03F97_PEDPA
          Length = 161

 Score =  193 bits (491), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 57/161 (35%), Positives = 91/161 (56%), Gaps = 4/161 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+I A  +   IG + ++PW++P D+A+FK+ T    V+MGR T++SIG+ LP RKNI
Sbjct: 1   MISMIWAEDLRHGIGKQQSIPWHIPGDMAFFKKTTSGNTVVMGRKTFDSIGKALPNRKNI 60

Query: 61  ILSSQPGT-DDRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +LS  P +  D V  V S+ E  AI       +  +IGG  +Y   L +A +L +T I  
Sbjct: 61  VLSHHPTSLPDSVVGVGSLSELQAIFETHPNEKFYIIGGSHLYNALLSQADELLITRIQK 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + + +   PD   ++++   S  H++  +N  +Y FE   R
Sbjct: 121 DYQCEVLAPDITQNEFKLASSVEHESTERNP-AYTFETWIR 160


>UniRef50_A4VUL2 Dihydrofolate reductase n=9 Tax=Streptococcus RepID=A4VUL2_STRSY
          Length = 170

 Score =  192 bits (489), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 50/164 (30%), Positives = 88/164 (53%), Gaps = 6/164 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           I  I A   + +IG  + +PW+LPADLA FK+ T    ++MGR T++ +G R LP R  I
Sbjct: 5   IVAIWAQDENGLIGKGDRLPWSLPADLAHFKKTTTGHTMVMGRITFDGMGKRALPNRHTI 64

Query: 61  ILSSQPGTD---DRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHID 116
           +L++        +R+T + SV++ +       + + VIGGG+++  F P  + L +T I 
Sbjct: 65  VLTTDKTYQLESERITILHSVEDVLDWYNKQEQTLFVIGGGQIFTAFAPYIETLIVTDIH 124

Query: 117 AEVEGDTHFPD-YEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +  GD +FP  +  + ++   +     D +N + +  +  ERR
Sbjct: 125 GQFNGDVYFPKAFPMEKFQLQSANLRPKDEKNPYDFTIKTYERR 168


>UniRef50_UPI00016B2267 dihydrofolate reductase n=1 Tax=candidate division TM7 single-cell
           isolate TM7c RepID=UPI00016B2267
          Length = 178

 Score =  192 bits (488), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 65/162 (40%), Positives = 88/162 (54%), Gaps = 8/162 (4%)

Query: 3   SLIAALAVDRVIGMENAMPW--NLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           ++I A   +R IG    +PW  +LPADLA FK+ T    +IMG  T+ESIG RPL  RKN
Sbjct: 17  AIIVAYDRNRAIGRGGDLPWGRSLPADLAHFKQLTKGGGIIMGHRTFESIGSRPLLERKN 76

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL--PKAQKLYLTHIDA 117
           I++SS+P   + V  V  +  A+A         +IGG RVY   L  P+   +Y T IDA
Sbjct: 77  IVISSRPTDSEGVLTVMDLPSALALSHYST--FIIGGARVYADALETPEIDTIYATEIDA 134

Query: 118 EVEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              G DT FP+ +   W+      H ADA N + + F I +R
Sbjct: 135 SFPGADTFFPEIDMSIWQETSRIRHPADADNVYDFDFVIYKR 176


>UniRef50_Q5HFZ7 Dihydrofolate reductase n=54 Tax=Staphylococcus aureus
           RepID=DYR_STAAC
          Length = 159

 Score =  192 bits (488), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 55/159 (34%), Positives = 92/159 (57%), Gaps = 4/159 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S++ A  + RVIG EN +PW+LP DL   K+ +    ++MGR T+ESIG+PLP R+N++
Sbjct: 3   LSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+S    + + V  + S+++     G    + + GG  ++E+ + K   +Y+T I+ +  
Sbjct: 63  LTSDTSFNVEGVDVIHSIEDIYQLPG---HVFIFGGQTLFEEMIDKVDDMYITVIEGKFR 119

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FP Y  +DWE   S     D +N+  + F  L R+
Sbjct: 120 GDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK 158


>UniRef50_UPI0001C37DF3 dihydrofolate reductase n=1 Tax=Ruminococcus flavefaciens FD-1
           RepID=UPI0001C37DF3
          Length = 160

 Score =  191 bits (487), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 60/161 (37%), Positives = 91/161 (56%), Gaps = 8/161 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA A + VIG    +PW++P D+A+F+R T    VIMGR T+E IGRPLPGR N+
Sbjct: 1   MISIIAAAAKNGVIGAGGKIPWDIPEDMAYFRRITYGGAVIMGRRTYEDIGRPLPGRFNV 60

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           ++S++  T  +      S+ EA+   G+     I + GG  VY + L  A ++YLT +D 
Sbjct: 61  VVSAKMQTAPEGTALAHSLAEAVEIAGNSGRENIFLCGGAAVYREGLAFADRIYLTILDK 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E  GD +FP++   ++     E  D+         F I ++
Sbjct: 121 EYSGDVYFPEFSEKEFRLTSYERCDSA-----PITFCIYDK 156


>UniRef50_Q5V600 Dihydrofolate reductase 2 n=1 Tax=Haloarcula marismortui
           RepID=DYR2_HALMA
          Length = 167

 Score =  191 bits (486), Expect = 6e-48,   Method: Composition-based stats.
 Identities = 68/164 (41%), Positives = 86/164 (52%), Gaps = 14/164 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR----PLPGR 57
           +SLIAA+A + VIG    +PW  P DL  FK  T+  PVIMGR T+ESI R    PLP R
Sbjct: 5   LSLIAAVAANGVIGAGGDIPWQYPEDLTHFKETTVGHPVIMGRRTFESIRRDLDGPLPER 64

Query: 58  KNIILSSQP-GTDDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTH 114
            NI+L++ P    D VT V S   A+A   D       VIGG  VYEQFLP+A +L LT 
Sbjct: 65  LNIVLTTTPHQLPDSVTAVTSTTAAVAEAADSDASTTYVIGGATVYEQFLPQADELILTE 124

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + A  +GDT FP  +  +W  +    H         +      R
Sbjct: 125 LAAAFDGDTVFPTVDWSNWTEMERTTHSE-------FAIVRYTR 161


>UniRef50_D1PCZ0 Dihydrofolate reductase n=1 Tax=Prevotella copri DSM 18205
           RepID=D1PCZ0_9BACT
          Length = 179

 Score =  190 bits (485), Expect = 9e-48,   Method: Composition-based stats.
 Identities = 59/181 (32%), Positives = 90/181 (49%), Gaps = 25/181 (13%)

Query: 1   MISLIAALAV-DRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRK 58
           M+S+IA ++   R IG +N + + +P+D+  F+  T    +IMGR T+ES+    LP R+
Sbjct: 1   MLSIIACISKVHRAIGYKNRLLYAIPSDMTRFRMLTTGHTIIMGRKTFESLPNGALPNRR 60

Query: 59  NIILSSQPGTDDRVTWVKSVDEAIAACGDV-------------------PEIMVIGGGRV 99
           NI++S             S++EA+AA  +                     E  +IGG  +
Sbjct: 61  NIVISKTREQITGCEVYTSLEEALAARKEEAARKEEVGNKETVGSKEASDECFIIGGASI 120

Query: 100 YEQFLPKAQKLYLTHIDAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           YEQ LP A KLYLT ++ E E  DT FP+  P +WE    E  +   +N   + F  L R
Sbjct: 121 YEQALPFADKLYLTIVEKEPEHADTFFPEINPAEWEVTEKEMRN---ENGLPFTFLTLYR 177

Query: 159 R 159
           +
Sbjct: 178 K 178


>UniRef50_Q38WX9 Dihydrofolate reductase n=5 Tax=Lactobacillales RepID=Q38WX9_LACSS
          Length = 166

 Score =  190 bits (485), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 52/163 (31%), Positives = 90/163 (55%), Gaps = 5/163 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MI+ + A   + +IG +  +PW LP DLA FKR T+N+ VIMGR T++S+  +PLPGR+N
Sbjct: 1   MIAFLWAEDQNGLIGQDGHLPWRLPNDLANFKRETINEAVIMGRKTYDSLPKKPLPGRQN 60

Query: 60  IILSSQPGT--DDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHI 115
           I+++ Q G      V       + +    + P  ++ +IGG  +++ F      LY+T I
Sbjct: 61  IVITRQSGLTVAKDVLVFNERTQLLDYQKEHPMQKLFIIGGADIFKLFAADVDYLYVTKI 120

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             + +GD + P  +   ++ +  +    D +N + + FEI +R
Sbjct: 121 AEKFKGDVYMPTIDYTQFKLISQKAGAVDERNQYPHTFEIYQR 163


>UniRef50_B5EIA1 Dihydrofolate reductase region n=5 Tax=Geobacter RepID=B5EIA1_GEOBB
          Length = 306

 Score =  190 bits (484), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 59/158 (37%), Positives = 91/158 (57%), Gaps = 4/158 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS IAAL+ +RVIG +  +PW++P+DL  F+  T+   VIMGR T+ESIG PL GR+NI
Sbjct: 2   IISTIAALSDNRVIGADGGLPWDIPSDLTRFRSITMGHTVIMGRKTYESIGHPLLGRRNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +L+ +    +     ++V  AIAA     E+ + GGG V+++ LP  Q+LYLT +     
Sbjct: 62  VLTRKGSQIEGCEIARNVPAAIAAAEGEEEVFICGGGEVFQEALPLCQRLYLTVVHGNYR 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD   P+  P+ +  +  E        +    F +LE+
Sbjct: 122 GDAFLPEL-PEGFVELHREEFP---DTTPPSSFVVLEK 155


>UniRef50_C6XGC7 Dihydrofolate reductase protein n=1 Tax=Candidatus Liberibacter
           asiaticus str. psy62 RepID=C6XGC7_LIBAP
          Length = 176

 Score =  190 bits (484), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 58/164 (35%), Positives = 85/164 (51%), Gaps = 7/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I LIAA+  + VIG    MPW + +DL  FK  T   PV+MG  T++SIGR LPGR NII
Sbjct: 6   IILIAAITRNNVIGSCGGMPWKISSDLKRFKSLTTGNPVVMGYRTFQSIGRLLPGRTNII 65

Query: 62  LSSQ----PGTDDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           ++         +       S+ +++         +I +IGGG +Y Q +  A  LY+THI
Sbjct: 66  ITRDNTRRASVNPEAVLASSILDSLDLASKTGSKKIFIIGGGEIYAQTISLAHTLYITHI 125

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFH-DADAQNSHSYCFEILER 158
           + E+EGD  FP  + + W+    E    A   + +   F I +R
Sbjct: 126 EKEIEGDVFFPSIDSNIWKKQEKEIITSAGEGDDYPTRFVIYDR 169


>UniRef50_C9MLK6 Dihydrofolate reductase n=2 Tax=Prevotella RepID=C9MLK6_9BACT
          Length = 161

 Score =  190 bits (483), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 55/160 (34%), Positives = 80/160 (50%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           +++IAA+A +R IG  N M + +  DL  FK+ T    VIMGR T+ S+ +  LP R+NI
Sbjct: 3   LNIIAAVAANRAIGYRNDMVYFIREDLKRFKQLTTGHTVIMGRKTFHSLPKGALPNRRNI 62

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI-DAEV 119
           +LS             S+DEA+       +  +IGG  +Y++ L  A +LYLT I D   
Sbjct: 63  VLSRTEKDFKGCEVYPSLDEAMRHIHADEQAFIIGGASLYKEALGIANRLYLTEIADTPA 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + D  FP Y    W     E H A   ++  Y F    R+
Sbjct: 123 QADVFFPPYNDGTWRVESREEHPA-TDDTPPYSFVNYVRK 161


>UniRef50_C2MBL2 Dihydrofolate reductase n=1 Tax=Porphyromonas uenonis 60-3
           RepID=C2MBL2_9PORP
          Length = 173

 Score =  190 bits (483), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 63/163 (38%), Positives = 88/163 (53%), Gaps = 6/163 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           I +I A A DR IG +  MPW L  DL   K  T    VIMGRHTW+SIG RPLP R NI
Sbjct: 3   IWIIVATARDRAIGRDGTMPWRLKDDLRRLKATTTGHAVIMGRHTWDSIGARPLPNRYNI 62

Query: 61  ILSSQ-PGTDDRVTWVKS-VDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++S   P  D    +V S +++A+  C       + ++GGG +Y+  LP A  L LT +D
Sbjct: 63  VVSRTLPEGDAETHYVASTLEQALQHCQQAGYDRVYIMGGGVLYKSGLPYATHLNLTMVD 122

Query: 117 AEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             V + DTHFP+    +W  +    + AD +N +     + +R
Sbjct: 123 TVVPDADTHFPEINLSEWSKLEEAHYPADERNDYPVTQTLYKR 165


>UniRef50_B2ICT5 Dihydrofolate reductase n=2 Tax=Beijerinckiaceae RepID=B2ICT5_BEII9
          Length = 198

 Score =  189 bits (482), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 59/165 (35%), Positives = 89/165 (53%), Gaps = 7/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++++AALA +RVIG+  AMPW+LP D   F+  T  KP++MGR T+ESIGR LPGR+ I+
Sbjct: 25  LTIVAALADNRVIGLNQAMPWDLPGDRRHFRERTWGKPMLMGRKTFESIGRALPGRETIV 84

Query: 62  LSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIM----VI--GGGRVYEQFLPKAQKLYLTH 114
           L+         V     ++ A+    D   IM    +I  GGG ++   LP+ ++L LT 
Sbjct: 85  LTRDETFAAPGVLVAHDLEGALGLAHDWARIMGAKTIILVGGGELFAALLPRVERLELTL 144

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           ++   +GDT FP  +   WE            ++ SY F    R+
Sbjct: 145 VEGNPKGDTFFPPIDWSQWEEEKRSGPLQGPNDTISYQFVDYHRK 189


>UniRef50_Q044A0 Dihydrofolate reductase n=13 Tax=Lactobacillus RepID=Q044A0_LACGA
          Length = 171

 Score =  189 bits (482), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 60/167 (35%), Positives = 86/167 (51%), Gaps = 8/167 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI  I A   D  IG +  +PW+LPADL  FK  T N  ++MGR T+ES    LP R++I
Sbjct: 3   MIRFIWAEDEDGHIGYQGTLPWHLPADLKHFKDLTSNHIIVMGRRTFESFPGLLPKRQHI 62

Query: 61  ILSSQP------GTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYL 112
           ILS+ P        +  V     + E      D  E  I +IGG RV+E+F+ +   +  
Sbjct: 63  ILSTSPTLQRKYQNNAHVKIFSQLKELKNWIKDHSEQTIDIIGGARVFEEFMDEVDMIEK 122

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T I    +GDT  P    +D+E + ++ H AD +N  +Y F   ER+
Sbjct: 123 TKIHHVFKGDTLMPKINYEDFELINTKAHQADEKNKFAYDFLEYERK 169


>UniRef50_B6BUF2 Dihydrofolate reductase n=1 Tax=beta proteobacterium KB13
           RepID=B6BUF2_9PROT
          Length = 148

 Score =  189 bits (482), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 46/152 (30%), Positives = 78/152 (51%), Gaps = 6/152 (3%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67
           ++ + VIG++N++PW+L  DL  FK  T    ++MGR T+ESIG+PLP R N +L+    
Sbjct: 1   MSENNVIGIDNSLPWHLSGDLKRFKAITTGHQIVMGRKTYESIGKPLPNRVNFVLTRNSD 60

Query: 68  TD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126
              D V  + S+++         +  +IGGG +Y Q +    +L +T I  E+ GD  FP
Sbjct: 61  LKIDGVHVISSLND---ISDSDKKTFIIGGGEIYSQLIDSCDELLVTKIHREIHGDAFFP 117

Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             +   W  V  +  +   +N   + +    +
Sbjct: 118 MIDASVWSLV--DQSEKLNENDIEFSYLTYRK 147


>UniRef50_Q8D3H9 FolA protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of
           Glossina brevipalpis RepID=Q8D3H9_WIGBR
          Length = 162

 Score =  189 bits (481), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 70/159 (44%), Positives = 103/159 (64%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A + ++VIG +  +PWNLP D++WFK+NT+NKPVIMGR T+ESI +PL  R NI+
Sbjct: 3   ISLIWAQSKNKVIGHDQYIPWNLPEDISWFKKNTINKPVIMGRKTFESIKKPLENRINIV 62

Query: 62  LSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           LS     +    +   K+  +A+    +  E+M+IGG ++Y+ FLPKA KLYLT I+AE+
Sbjct: 63  LSKNLYRNVMSNLKIAKNPKQALFFAKNYNEVMIIGGKQIYKIFLPKATKLYLTVINAEI 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            G+  FP Y    W   F ++ ++D +N +S  F I  +
Sbjct: 123 NGNIFFPRYNRKKWILSFEKYFNSDTKNKYSMYFRIFNK 161


>UniRef50_B9XJM4 Dihydrofolate reductase n=1 Tax=bacterium Ellin514
           RepID=B9XJM4_9BACT
          Length = 156

 Score =  189 bits (480), Expect = 4e-47,   Method: Composition-based stats.
 Identities = 58/128 (45%), Positives = 78/128 (60%), Gaps = 1/128 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
              IAA++ +RVIG  N +PW+LP D  WFK+ T  + V+MGR T+ESIGRPLP R+ I+
Sbjct: 4   FKAIAAMSQNRVIGQGNKIPWHLPEDFKWFKKMTTGQVVVMGRKTFESIGRPLPNRETIV 63

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           LS  P     V  +  + E I+   +  EI + GG ++YEQ LP    LYLT +   VEG
Sbjct: 64  LSRGPFQHPGVRTIFDLSE-ISLADESREIFICGGAQIYEQTLPMCSDLYLTVLKRTVEG 122

Query: 122 DTHFPDYE 129
           D  FP +E
Sbjct: 123 DAFFPTFE 130


>UniRef50_A1SJ32 Dihydrofolate reductase n=1 Tax=Nocardioides sp. JS614
           RepID=A1SJ32_NOCSJ
          Length = 160

 Score =  188 bits (479), Expect = 4e-47,   Method: Composition-based stats.
 Identities = 54/144 (37%), Positives = 82/144 (56%), Gaps = 2/144 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + L+AA+A + VIG    +PW LP +   FK  T    ++MGR T++SIGRPLPGR  I+
Sbjct: 8   VVLVAAVARNGVIGDGPDIPWQLPGEQRLFKGLTWGHILVMGRATYDSIGRPLPGRTTIV 67

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           L+  P  + + V     +  A+A    +  E+MV GGG+VY   LP A +  L+ +D E 
Sbjct: 68  LTRSPDWSAEGVHVAHDLPAALALADTLEGEVMVAGGGQVYAAALPVADEQVLSEVDLEP 127

Query: 120 EGDTHFPDYEPDDWESVFSEFHDA 143
           +GD  +P+++  +W     E HD 
Sbjct: 128 QGDAFYPEFDRSEWRETAREQHDG 151


>UniRef50_C7NFY1 Dihydrofolate reductase n=3 Tax=Actinomycetales RepID=C7NFY1_KYTSD
          Length = 337

 Score =  188 bits (478), Expect = 7e-47,   Method: Composition-based stats.
 Identities = 55/177 (31%), Positives = 83/177 (46%), Gaps = 28/177 (15%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++L+ A+A +  IG +  +PW+LP DL  FK  T+   ++MGR T+ES  RPLPGR++++
Sbjct: 168 LTLVVAVARNGAIGRDGDLPWHLPGDLKHFKDTTMGGTMVMGRRTFESFPRPLPGRRHVV 227

Query: 62  LSSQPGT----------------DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLP 105
           ++S P                   D V   +S  EA+   GD  E+ V+GG  V+   LP
Sbjct: 228 MTSDPTWLPGGPAVEGDPASGARFDEVLVARSWAEALLMAGDG-EVFVVGGAGVFADALP 286

Query: 106 KAQKLYLTHIDAEV-EGDTHFP---DYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            A +L LT +D    + DT FP     +P  W        +        Y      R
Sbjct: 287 VADRLVLTEVDQSPQDADTFFPITWPVDPTVWHESSRTPGEG-------YAIVEYRR 336


>UniRef50_Q54801 Dihydrofolate reductase n=65 Tax=Streptococcus RepID=DYR_STRPN
          Length = 168

 Score =  187 bits (477), Expect = 8e-47,   Method: Composition-based stats.
 Identities = 57/162 (35%), Positives = 94/162 (58%), Gaps = 4/162 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKNI 60
           I  I A   + VIG EN +PW+LPA+L  FK  TLN  ++MGR T++ +GR  LP R+ +
Sbjct: 5   IVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPKRETL 64

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           IL+  P    D V   + V   +       + + +IGG ++++ F P   ++ +THI A 
Sbjct: 65  ILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHAR 124

Query: 119 VEGDTHFP-DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           VEGDT+FP + +   +E+V S+F+  D +N + +  +  +R+
Sbjct: 125 VEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRK 166


>UniRef50_Q0SWS9 Dihydrofolate reductase n=1 Tax=Clostridium perfringens SM101
           RepID=Q0SWS9_CLOPS
          Length = 161

 Score =  187 bits (475), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 57/161 (35%), Positives = 93/161 (57%), Gaps = 6/161 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M S+I A +++ +IG+ N +PWN+P+DL  FK  T+ K ++MGR T+ES+   LPGR ++
Sbjct: 1   MFSIIVAKSINNIIGVNNKIPWNIPSDLKRFKELTMGKKILMGRKTFESLPFVLPGRTHL 60

Query: 61  ILSSQPGT---DDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +L+++         V     +D+ I+   D   EI VIGGG++Y +FL  A KLY+T + 
Sbjct: 61  VLTTKKDFSYNHKDVIIYNDLDKLISEYKDSMEEIFVIGGGKIYSEFLKYASKLYITEVL 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
            E +GDT+FP  +   W   +        +N+  + + I E
Sbjct: 121 KEYKGDTYFPKVDYSKWIKTYE--SSIYEENATKFKYVIYE 159


>UniRef50_C8WCM1 Dihydrofolate reductase region n=4 Tax=Zymomonas mobilis
           RepID=C8WCM1_ZYMMN
          Length = 165

 Score =  186 bits (474), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 57/160 (35%), Positives = 86/160 (53%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I LI A A + VIG +N MPW++ ADL  FK  TL  P+IMGR T+ES+   LP R +I+
Sbjct: 7   IMLIFARAQNGVIGKDNTMPWHISADLKHFKALTLGHPMIMGRRTFESLPGLLPKRPHIV 66

Query: 62  LSSQ-PGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           L+       +    V  ++EAI A      +I VIGG  +++QF  KA ++ LT I  + 
Sbjct: 67  LTHNHHWQAEGAEVVCDLEEAIKAARKYSSQIAVIGGANIFQQFWDKADRIELTEIYRDY 126

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GDT     + + +  V  E   A+ +   ++ F+   R+
Sbjct: 127 SGDTFVDLPDMNHFSLVGQEDFKAEGECP-AFSFKSFLRK 165


>UniRef50_D1PWR8 Dihydrofolate reductase n=1 Tax=Prevotella bergensis DSM 17361
           RepID=D1PWR8_9BACT
          Length = 163

 Score =  186 bits (473), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 51/142 (35%), Positives = 79/142 (55%), Gaps = 2/142 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           IS+I A+A +R IG  N + ++LP D+  FK  T    +IMGRHT++S+    L  R+NI
Sbjct: 3   ISIIVAMARNRAIGFRNHLLYHLPDDMKHFKALTTGHTIIMGRHTFDSLPNGALLHRRNI 62

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119
           ++S             S+++AIA+C    E+ +IGG  +Y Q L  A ++YLT +D    
Sbjct: 63  VVSRSRTHIVGCEVFGSLEQAIASCRGEQEVFIIGGESIYRQALAVAHRIYLTLVDDTPT 122

Query: 120 EGDTHFPDYEPDDWESVFSEFH 141
           + DT FP+ +   W+    E H
Sbjct: 123 QFDTVFPEIDMSHWQETKKEKH 144


>UniRef50_Q5M5B2 Dihydrofolate reductase n=9 Tax=Streptococcus RepID=Q5M5B2_STRT2
          Length = 167

 Score =  185 bits (472), Expect = 3e-46,   Method: Composition-based stats.
 Identities = 56/160 (35%), Positives = 90/160 (56%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKNI 60
           I  I A A + VIG  + MPW+LPA+LA FK+ T+   ++MGR T++ + R  LPGR+ +
Sbjct: 5   IIAIWAEARNHVIGKNHTMPWHLPAELAHFKKTTMGSAILMGRVTFDGMNRRCLPGRETL 64

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACG-DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           IL+     D + VT V SV+EA+A       ++ + GG  VY+ F      L  T I+A+
Sbjct: 65  ILTRDKDFDCEEVTTVTSVEEALAWFEQQDKDLYIAGGASVYKAFDGHYDVLIKTTIEAD 124

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +EGDT+FP  +   ++ V       + +N++ +     E+
Sbjct: 125 LEGDTYFPQLDTTAFKEVSRNRVPKNEKNAYDFSISRYEK 164


>UniRef50_B7H0P5 Dihydrofolate reductase type 3(Dihydrofolate reductasetype III)
           n=19 Tax=Acinetobacter RepID=B7H0P5_ACIB3
          Length = 181

 Score =  185 bits (471), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 55/160 (34%), Positives = 86/160 (53%), Gaps = 9/160 (5%)

Query: 5   IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64
           + A+  +  IG  NA+PW++ ADL  FK  T    VIMGR T ES+GR LP R N +++ 
Sbjct: 11  VVAMDKNHCIGKGNALPWHISADLKHFKEITQGGVVIMGRKTLESMGRALPNRVNWVITR 70

Query: 65  QPGTD-DRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
                 D V    S+++A+ A        +   + +IGGG +++Q L  A +L LTH+D 
Sbjct: 71  DINWHFDGVKIAYSIEDALNAALEDAKNTEKQALFIIGGGEIFKQTLSIADRLELTHVDL 130

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
           +V+GD H+P   P ++    SE    D ++  S+ F   +
Sbjct: 131 DVQGDAHYPTI-PSEFHKTASEQ-QVDEKSGTSFEFATYK 168


>UniRef50_C5NYS7 Dihydrofolate reductase n=1 Tax=Gemella haemolysans ATCC 10379
           RepID=C5NYS7_9BACL
          Length = 163

 Score =  185 bits (470), Expect = 5e-46,   Method: Composition-based stats.
 Identities = 51/160 (31%), Positives = 88/160 (55%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M+SLI A   ++ IG EN +PW L  D+   K  T N+ +IMGR T +SIGR LP R N 
Sbjct: 1   MLSLIVAYDKNKSIGQENTIPWRLKNDMLRVKELTTNQTIIMGRKTLDSIGRALPNRINR 60

Query: 61  ILSSQPGTDDRVTWVK-SVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L+    +    + ++   D++I    +  +  + GGG +Y ++  K  ++++T ++  V
Sbjct: 61  VLTRDKDSLSHYSNIEVYTDDSILDNIETEKAYIFGGGMIYNKYFDKCDEMFITEVNTIV 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E DT FP+++ ++WE +  E    D  N   + F   +R+
Sbjct: 121 EADTKFPEFDENEWELISREEFFKDENNEFDFVFIHFKRK 160


>UniRef50_A5VJL0 Dihydrofolate reductase n=8 Tax=Lactobacillus RepID=A5VJL0_LACRD
          Length = 162

 Score =  184 bits (468), Expect = 9e-46,   Method: Composition-based stats.
 Identities = 58/158 (36%), Positives = 86/158 (54%), Gaps = 4/158 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           ++LI A  ++  IG +N +PW++ AD+  FK  T   P+IMGR T+ S+G +PLP R+NI
Sbjct: 4   LNLIWAEDLNGWIGKDNTIPWHVSADMKHFKTKTTGHPIIMGRRTFASLGNKPLPKRENI 63

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACG-DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L+S+    + V  V S+         +  E  VIGG  +Y+Q LP A KL  T I+ ++
Sbjct: 64  VLTSRNIDAEGVEVVHSLAALKEYLKANPNEYFVIGGATIYQQLLPMATKLTRTVINKQI 123

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
            GDT  P  + D W  V    ++ D Q      FE  E
Sbjct: 124 VGDTKMPTIDYDRWHLVNHNNYEKDDQ--LICRFEEWE 159


>UniRef50_A0JZC8 Dihydrofolate reductase n=11 Tax=Bacteria RepID=A0JZC8_ARTS2
          Length = 194

 Score =  184 bits (468), Expect = 9e-46,   Method: Composition-based stats.
 Identities = 60/170 (35%), Positives = 84/170 (49%), Gaps = 14/170 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           + L+ A     VIG +  MPW+LP D+  F R T   PVIMGR TW S     RPLPGR 
Sbjct: 23  VGLVWAQTTAGVIGKDGDMPWHLPEDMKHFTRLTTGHPVIMGRKTWLSFPDKYRPLPGRT 82

Query: 59  NIILSSQPGTDD-----RVTWVKSVDEAI---AACGDVPEIMVIGGGRVYEQFLPKAQKL 110
           NI+++ Q G  D         VKS+D+A+           + V+GGG ++ Q L  A   
Sbjct: 83  NIVVTRQEGWGDTPDARGAIAVKSLDDALLESQFAPGHETVWVLGGGEIFAQTLDIADVA 142

Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEF--HDADAQNSHSYCFEILER 158
            +T ID+E +GDT+ P+    +W+   SE       +     Y F +  R
Sbjct: 143 VVTFIDSETDGDTYAPELGY-EWKLAASEPATGWLTSATGTRYRFTMWRR 191


>UniRef50_Q18HG9 Dihydrofolate reductase n=4 Tax=Halobacteriaceae RepID=Q18HG9_HALWD
          Length = 195

 Score =  184 bits (468), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 66/164 (40%), Positives = 89/164 (54%), Gaps = 18/164 (10%)

Query: 6   AALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNII 61
           AA+A + +IG +  MPW++PADL  FKR T+  PVI+GR T+E+I    G P PGR +I+
Sbjct: 37  AAVAANDIIGRDGEMPWHIPADLQQFKRRTMGHPVILGRRTYEAIIGALGEPFPGRTSIV 96

Query: 62  LSSQP-GTDDRVTWVKSVDEAIAACGDVPE------IMVIGGGRVYEQFLPKAQKLYLTH 114
           LSSQ       V  V S+  AI              + V GGG VYEQFLP A +L LT 
Sbjct: 97  LSSQSRDVPADVILVHSITSAIREASKNARERGVGTVYVAGGGGVYEQFLPLADRLRLTE 156

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +  E EGDT FP ++   W+    E ++       ++ F   ER
Sbjct: 157 LHDEYEGDTKFPSWDDTVWQETTREKNE-------TFDFVTYER 193


>UniRef50_A6WGF8 Dihydrofolate reductase n=5 Tax=Actinomycetales RepID=A6WGF8_KINRD
          Length = 171

 Score =  184 bits (467), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 64/163 (39%), Positives = 83/163 (50%), Gaps = 11/163 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           MI L+ A + + VIG    +PW +P DLA F   T    V+MGR TWES+    RPLPGR
Sbjct: 1   MIGLVWAQSRNGVIGAGGRIPWRVPEDLAHFSALTAGSTVVMGRATWESLPARFRPLPGR 60

Query: 58  KNIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +N++LS  PG   +    V  +  A+A  GD   + VIGG  VY   L  A  L +T +D
Sbjct: 61  RNLVLSRDPGYAAEGAEVVHDLPGALAGAGD---VWVIGGSAVYRAALEHADVLVVTEVD 117

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHD-ADAQNSHSYCFEILER 158
             VEGDT  P+  P  WE V  E  D A +     +      R
Sbjct: 118 LVVEGDTRAPEVGPG-WERV--EVGDWATSTGGPRFRIGTWRR 157


>UniRef50_Q7UIC9 Dihydrofolate reductase n=1 Tax=Rhodopirellula baltica
           RepID=Q7UIC9_RHOBA
          Length = 195

 Score =  184 bits (467), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 58/159 (36%), Positives = 85/159 (53%), Gaps = 3/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+ + A   + VIG +  MPW L +DL  FK+ T+   +IMGR T+ESIGR LPGR+ I+
Sbjct: 31  ITAVVAATPNGVIGDDQDMPWRLSSDLKRFKKATMGGALIMGRKTFESIGRVLPGRQTIV 90

Query: 62  LSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+ Q               EAIA   D   I V+GGG++Y+Q+ P   +L+ T + A V 
Sbjct: 91  LTRQGHWQFPGTQTASGKSEAIALAADR-RIFVVGGGQIYQQWFPLCTELWWTRVWANVS 149

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT   D   D++E V        A++ +   +  + RR
Sbjct: 150 GDTRV-DLPLDEFELVSQTSFPVTAKDDYPTDWLRMRRR 187


>UniRef50_D2LGH8 Dihydrofolate reductase n=1 Tax=Rhodomicrobium vannielii ATCC 17100
           RepID=D2LGH8_RHOVA
          Length = 178

 Score =  184 bits (467), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 53/166 (31%), Positives = 86/166 (51%), Gaps = 9/166 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++L+ A A + VIG E  +PW L +DL  F+R T+  P+IMGR T+ SIG+PL GR ++I
Sbjct: 9   LALVVAAAENDVIGREGKLPWRLKSDLKRFRRLTMGHPLIMGRKTFASIGKPLDGRDSVI 68

Query: 62  LSSQPGT---DDRVTWVKSVDEAIAA------CGDVPEIMVIGGGRVYEQFLPKAQKLYL 112
           ++    +      V    S+ +A+           V E  VIGG  ++   LP A +++L
Sbjct: 69  VTRDAASVSPQPGVFVATSIKDALDIARARAAERRVAEAFVIGGAEIFALALPYADRIHL 128

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             + A   GD ++     ++W+ V  E   A+  +  S    +LER
Sbjct: 129 ARVHASPSGDAYWQAPPAEEWQVVSREEWPANQTDEFSVTDLVLER 174


>UniRef50_Q494F1 Dihydrofolate reductase type I n=1 Tax=Candidatus Blochmannia
           pennsylvanicus str. BPEN RepID=Q494F1_BLOPB
          Length = 164

 Score =  183 bits (465), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 76/162 (46%), Positives = 106/162 (65%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           +ISLIAAL  + +IG +N +PW LP D+ WFK +TL KP+IMGR T+ESIG +PL  R N
Sbjct: 2   IISLIAALTTNHIIGKKNVIPWYLPIDIKWFKYHTLYKPIIMGRKTFESIGKKPLLNRLN 61

Query: 60  IILSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA- 117
           I+LS       + V   +++DEA++   D  E+MVIGG  +Y  FLP+AQ+LYLT+I   
Sbjct: 62  IVLSRNLLNNYNGVFIAENIDEALSLIQDAYEVMVIGGSEIYNVFLPRAQRLYLTYIHNM 121

Query: 118 -EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            E++GD  FPDY+  +W+S+F+ F+           F ILER
Sbjct: 122 VEIDGDILFPDYDIREWKSIFNSFYKVREDCFCYLHFSILER 163


>UniRef50_B2GC42 Dihydrofolate reductase n=4 Tax=Lactobacillus RepID=B2GC42_LACF3
          Length = 167

 Score =  183 bits (465), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 54/158 (34%), Positives = 83/158 (52%), Gaps = 4/158 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+ I A      IG +N MPW+L ADL  FK  T   PVIMG++T+ S+GRPLP R NI+
Sbjct: 4   IAFIWAEDEAGWIGKDNDMPWHLSADLKHFKHLTSGHPVIMGKNTYLSLGRPLPKRTNIV 63

Query: 62  LSSQPGTDDRVTWVKSVD---EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++ Q    + VT V  V+   + +A  G+  E+ +IGG  ++   +  A  LY T ++ +
Sbjct: 64  VTRQTTPIEGVTLVNGVNALTDLLANYGEDEEVFIIGGAHLFASTMSLATVLYRTVVEGD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
             GD      +   W+ V +E H    ++  +  FE  
Sbjct: 124 HHGDVKMAPIDYRTWQKV-AERHLQATESDPACTFEKW 160


>UniRef50_B8HHJ9 Dihydrofolate reductase n=2 Tax=Micrococcineae RepID=B8HHJ9_ARTCA
          Length = 181

 Score =  183 bits (465), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 64/169 (37%), Positives = 91/169 (53%), Gaps = 12/169 (7%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           +I +I A A + VIG +  MPW+LP D   F+R T    VIMGR TWES+    RPLPGR
Sbjct: 7   VIGMIWAQASNGVIGRDGTMPWHLPEDFEHFRRTTEGHSVIMGRRTWESLPEPFRPLPGR 66

Query: 58  KNIILSSQPG-TDDRVTWVKSVDEAIAACGDVP---EIMVIGGGRVYEQ--FLPKAQKLY 111
           +N++++S P  +        S+  A+AA    P   ++ +IGGG VY +  FL  A    
Sbjct: 67  RNLVITSDPAWSAPGAVRSSSILNALAAAAGQPGSDQVWIIGGGMVYREALFLRAANTAV 126

Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHD--ADAQNSHSYCFEILER 158
           +T I ++++GDT+ P+  PD WE   +E       A N   Y  E   R
Sbjct: 127 ITLIASDIDGDTYAPELGPD-WEMASAEPGVGWTTAANGTRYRIETWTR 174


>UniRef50_C3RMT4 Dihydrofolate reductase n=4 Tax=Bacteria RepID=C3RMT4_9MOLU
          Length = 156

 Score =  182 bits (464), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 58/162 (35%), Positives = 95/162 (58%), Gaps = 11/162 (6%)

Query: 1   MISLIAALAVDRVIGME---NAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGR 57
           MI++I A   D +IG +   N MPWN+P DL  FK  TLNK ++MG  T+++IGRPLP R
Sbjct: 1   MINIIVATDEDLLIGKKDSRNGMPWNVPEDLQHFKATTLNKTILMGLTTYQAIGRPLPNR 60

Query: 58  KNIILSSQPGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           K I++S +P  D+RV    S++E I        ++ + GG  +Y+Q LP A +L ++ I 
Sbjct: 61  KTIVVSFEPFEDERVEVRSSLEEVIEEYRSSGEDLFISGGASIYKQCLPIADQLLISRIP 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            + EG+T+FP+++   ++ V  +  +       ++  E  +R
Sbjct: 121 GKHEGETYFPNFDEYGYKLVAQKPFE-------TFTLETYKR 155


>UniRef50_UPI00016BFCBD Dihydrofolate reductase n=1 Tax=Epulopiscium sp. 'N.t. morphotype
           B' RepID=UPI00016BFCBD
          Length = 161

 Score =  182 bits (464), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 56/154 (36%), Positives = 94/154 (61%), Gaps = 4/154 (2%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +I A++ +  IG+ N +PWN+  D+ +F++ T  K VIMGR T+ SIGRPLP R+NI+L+
Sbjct: 1   MIVAVSKNGQIGIANELPWNIKEDMNYFRKMTTAKTVIMGRKTFNSIGRPLPNRRNIVLT 60

Query: 64  SQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
           +        V  V +  EA+    +  +  VIGGG++YE F+P A++LY+T +D +++GD
Sbjct: 61  TNTDLKIAGVEVVTNFAEALIIARE-EDAFVIGGGQIYELFMPYAEELYITEVDIDIDGD 119

Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
             FP+Y  + +  V +    A+  + ++Y F   
Sbjct: 120 AAFPEY-RNKFVCVETIEKSAN-DSKYNYRFTKW 151


>UniRef50_Q0TV23 Dihydrofolate reductase n=8 Tax=Clostridium perfringens
           RepID=Q0TV23_CLOP1
          Length = 161

 Score =  182 bits (463), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 54/162 (33%), Positives = 91/162 (56%), Gaps = 6/162 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M S+I A +++ +IG+ N MPWN+P+DL  FK  T+ K ++MGR T+ES+   LPGR ++
Sbjct: 1   MFSIIVAKSINNIIGVNNKMPWNIPSDLKRFKELTMGKKILMGRKTFESLPFVLPGRTHL 60

Query: 61  ILSSQPGT---DDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +L+++         V     +++ I+   D   EI VIGGG++Y + L    KLY+T + 
Sbjct: 61  VLTTKKDFSYNHKDVIIYNDLNKLISEYKDSMEEIFVIGGGKIYSELLKYTSKLYITEVL 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            E +GDT+FP  +   W   +        +N + + F   ++
Sbjct: 121 KEYKGDTYFPKVDYYKWIKTYESSIH--EENGNKFKFFNYKK 160


>UniRef50_D0VXF2 Putative uncharacterized protein dfrP n=1 Tax=Bacillus phage
           phiNIT1 RepID=D0VXF2_9VIRU
          Length = 168

 Score =  182 bits (462), Expect = 4e-45,   Method: Composition-based stats.
 Identities = 56/161 (34%), Positives = 91/161 (56%), Gaps = 5/161 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LIAA+ ++  IG +N + W++  D+ WF++ T NK V+MGR T+ESIG+PL GR N++
Sbjct: 3   VALIAAMGLNLEIGADNRLLWDIKEDMNWFRQKTKNKVVVMGRKTYESIGKPLKGRVNVV 62

Query: 62  LSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           L+     D    V    ++++      +  EIMVIGG  +Y QF P A ++YLT ++   
Sbjct: 63  LTHNKEYDPHPDVLVRHNLEDIFFEFRNELEIMVIGGETIYNQFFPYANRIYLTQVEKTY 122

Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            E D  FP+++   W   F  + D        Y F + ++R
Sbjct: 123 EEADAFFPEFDCSIWNRYF--YQDGSEDIGIKYNFSVYKKR 161


>UniRef50_Q89AV2 Dihydrofolate reductase n=5 Tax=Buchnera aphidicola RepID=DYR_BUCBP
          Length = 164

 Score =  182 bits (462), Expect = 5e-45,   Method: Composition-based stats.
 Identities = 71/160 (44%), Positives = 106/160 (66%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A++ + VIG +N++PWN+P DL+WFK++T+ K +IMGR TWESIGR LP R+NI+
Sbjct: 3   ISIIVAMSQNLVIGQKNSIPWNIPKDLSWFKKHTIKKSIIMGRKTWESIGRVLPMRQNIV 62

Query: 62  LSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+ Q    +  V +V S+ +AI +     EIM+IGG  +Y Q L  A KLY+THI+  + 
Sbjct: 63  LTRQKNIKNTNVLFVNSISKAIQSALYKNEIMIIGGSNLYNQMLTSANKLYITHIEKYIL 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADA--QNSHSYCFEILER 158
           GDT+FP Y+   W+ +F +        +NS    F+IL++
Sbjct: 123 GDTYFPTYDHLPWKIIFKKKIIEHEKTKNSFYVTFKILKK 162


>UniRef50_D0J8Z9 Dihydrofolate reductase n=2 Tax=Blattabacterium RepID=D0J8Z9_BLASP
          Length = 173

 Score =  181 bits (461), Expect = 5e-45,   Method: Composition-based stats.
 Identities = 59/172 (34%), Positives = 90/172 (52%), Gaps = 16/172 (9%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I LI+A++ + VIG  N + W+LP DL  FK  T  + V+MGR T+ESIG+ LPGR+NII
Sbjct: 3   IILISAVSSNGVIGKNNQLMWHLPNDLKRFKNMTFGETVLMGRKTFESIGKILPGRRNII 62

Query: 62  LS--------SQPGTDDR------VTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKA 107
           L+        S   T+++           S+ +      +  +I VIGG ++Y   + KA
Sbjct: 63  LTKKNKIHFFSSTNTNNKTNPRGTFEVYSSLKQIYDL--NYKKIFVIGGEKIYTSTIDKA 120

Query: 108 QKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
             + LT I  +  GD  FP      W+  +  FH+ D  + ++Y F   ER+
Sbjct: 121 HIIELTVIHKKFYGDAKFPKIPLSKWKKTYEFFHEKDKHHLYNYSFIRYERK 172


>UniRef50_Q3F0Y0 Dihydrofolate reductase n=2 Tax=Bacillus thuringiensis
           RepID=Q3F0Y0_BACTI
          Length = 172

 Score =  180 bits (459), Expect = 9e-45,   Method: Composition-based stats.
 Identities = 57/171 (33%), Positives = 82/171 (47%), Gaps = 12/171 (7%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MISLI A   +  IG EN +   L  D+  F + T  KP+IMG  T+ S+G +PL  R N
Sbjct: 1   MISLIVAADENNAIGFENKLLCRLKDDMKHFIKKTKGKPIIMGYKTFASLGHKPLKDRFN 60

Query: 60  IILSSQPGT--------DDRVTWVKSVD--EAIAACGDVPEIMVIGGGRVYEQFLPKAQK 109
           I+L+  P                 +S++  + +       EI+VIGG + YE FLP A +
Sbjct: 61  IVLTRSPMALTLDHLHLVGENLVFESLEYIQFMIEQSKDKEIVVIGGQQTYELFLPMASR 120

Query: 110 LYLTHIDAEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +YLT I     E D++FP  +  +W S     H     N H +     ER+
Sbjct: 121 VYLTRIHHSFPEADSYFPMLDSSEWSSKLDAKHAESEDNDHPFSIYTFERK 171


>UniRef50_Q6A328 Dihydrofolate reductase n=1 Tax=Pasteurella multocida
           RepID=Q6A328_PASMU
          Length = 169

 Score =  180 bits (459), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 49/164 (29%), Positives = 77/164 (46%), Gaps = 8/164 (4%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRKN 59
           SLI A+   R +G +N + W+LP D+ +FK  T    V+MGR +WESI    RPLP R N
Sbjct: 6   SLIVAIGKHREMGADNDLLWHLPRDMQFFKETTTGHAVVMGRKSWESIPQKYRPLPNRLN 65

Query: 60  IILSSQPGT-DDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLP--KAQKLYLTHI 115
            +L+       +  T +  + E             +IGG ++Y+  L      ++Y+T +
Sbjct: 66  FVLTRDKNYSAEGATVIYDLKEVAQHLEGKNLTCFIIGGAQIYQLALETGLLNEMYVTQV 125

Query: 116 DAEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
                E DT FP     +WE       D D ++ +S+  +   R
Sbjct: 126 HNTFEEADTFFPFVNWGEWEEEDILEQDKDEKHLYSFNIKKFTR 169


>UniRef50_B2UP70 Dihydrofolate reductase n=1 Tax=Akkermansia muciniphila ATCC
           BAA-835 RepID=B2UP70_AKKM8
          Length = 159

 Score =  180 bits (458), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 59/154 (38%), Positives = 83/154 (53%), Gaps = 8/154 (5%)

Query: 5   IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64
           + A+A DR IG   A+PW+LP DL  FKR T   PV+MGR T+ESIGRPLPGR+NI+L+ 
Sbjct: 10  VVAMAPDRGIGYRGALPWHLPDDLKTFKRITTGHPVLMGRKTYESIGRPLPGRQNIVLTR 69

Query: 65  QPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDT 123
            P  T + V  V S  E        PEIMVIGG  ++   +P   +++++ +  E   DT
Sbjct: 70  DPAWTAEGVQVVHSAGELECLELMDPEIMVIGGAEIFSLMMPAMSRMWVSKVKGEYPADT 129

Query: 124 HFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
             P +E     +V  E  +        +   + E
Sbjct: 130 FLPPFENRLERAVLKEHFE-------DFDLYLYE 156


>UniRef50_B1MYC2 Dihydrofolate reductase n=3 Tax=Leuconostoc RepID=B1MYC2_LEUCK
          Length = 166

 Score =  180 bits (458), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 56/162 (34%), Positives = 86/162 (53%), Gaps = 4/162 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I ++ A      IG    + W+LP DL  FK  T+N  ++MGR TW++IGRPLPGR +++
Sbjct: 4   IRMVWAEDSTHAIGKNGQLAWHLPDDLKLFKAETMNTLMVMGRTTWDTIGRPLPGRTSLV 63

Query: 62  LSSQPGTD---DRVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           L+ Q       D V    SVDE +     +  +I + GG  +Y  F+P A  L +T ID 
Sbjct: 64  LTHQKDFKTPYDDVIIAHSVDEVLDYIEKETRDISIAGGAAIYHAFMPYATDLIVTRIDV 123

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + GDT     +   ++ V +  HD D ++ +S+  E  ER+
Sbjct: 124 TIAGDTFVDAIDLSQFKLVSATAHDKDDKHDYSFVVERYERQ 165


>UniRef50_D1BYH5 Dihydrofolate reductase n=1 Tax=Xylanimonas cellulosilytica DSM
           15894 RepID=D1BYH5_XYLCX
          Length = 185

 Score =  180 bits (458), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 60/185 (32%), Positives = 81/185 (43%), Gaps = 26/185 (14%)

Query: 1   MISLIAALAVDR----VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLP 55
           MI+LI A A D     VIG    +PW +  D   F+  T   PV+MGR TW+S+  RPLP
Sbjct: 1   MIALIWAQARDTAGRPVIGAGGDIPWRVAEDFTRFRTLTTGHPVVMGRRTWDSLPRRPLP 60

Query: 56  GRKNIILSSQPGTDDR---------------VTWVKSVDEAIAACGDVPE---IMVIGGG 97
           GR N++++ QP                    V    ++DEA+      P    + +IGG 
Sbjct: 61  GRTNVVVTRQPDWRPDDDGAVVTAGAPEATAVVVATTLDEALDGATQAPGGDLVWIIGGA 120

Query: 98  RVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHD---ADAQNSHSYCFE 154
            +Y Q L  A +L +T ID  V+GD   P  +P  W        D        S  Y F 
Sbjct: 121 EIYGQALAVADRLEVTEIDLVVDGDAFAPAIDPVHWHEGQHGHGDWVSPARPESPRYRFR 180

Query: 155 ILERR 159
              RR
Sbjct: 181 TYVRR 185


>UniRef50_Q1GFV5 Dihydrofolate reductase n=18 Tax=Rhodobacterales RepID=Q1GFV5_SILST
          Length = 163

 Score =  180 bits (457), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 56/139 (40%), Positives = 83/139 (59%), Gaps = 6/139 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MI+LI A A +  IG +N +PW+ P DL  F+R TL   +IMGR+TW+S+  +PL  R N
Sbjct: 1   MITLIVARARNGAIGKDNDIPWHAPEDLKAFQRETLGGAIIMGRNTWDSLPFKPLKNRFN 60

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           I++SS P   D  T V S+DEAI          +  IGG  +Y+  L +A +L +T +D 
Sbjct: 61  IVVSSNPDAAD--TVVASLDEAIDLARSEGYARLYGIGGAGIYKGMLARADRLMITEVDL 118

Query: 118 EV-EGDTHFPDYEPDDWES 135
           E+ + D  FP++ P++W  
Sbjct: 119 EIDDADAFFPEFPPEEWRV 137


>UniRef50_C4Z3U6 Dihydrofolate reductase n=8 Tax=Firmicutes RepID=C4Z3U6_EUBE2
          Length = 157

 Score =  179 bits (455), Expect = 3e-44,   Method: Composition-based stats.
 Identities = 52/161 (32%), Positives = 87/161 (54%), Gaps = 7/161 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI LI A + + VIG    +PW +  +  +FK  T+   V+MGR ++E IG PLP R+NI
Sbjct: 1   MIGLIVARSKNNVIGRNGEIPWKIKGEQKFFKELTIGNIVVMGRKSYEEIGHPLPNRQNI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I+S     + + +  V S+ EA+A   D   I + GG  VY++ +P    +Y+T +D  +
Sbjct: 61  IVSKTMKYEGENLITVSSLAEALAL-SDNSNIYIAGGYGVYKEAIPFVDVMYITEVDMNI 119

Query: 120 E-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E GD  FP+++ +D++ +  E    + +    Y      R+
Sbjct: 120 EDGDVFFPEFDVNDFDLIIGETFGENTK----YTRTTYIRK 156


>UniRef50_Q2S5H3 Dihydrofolate reductase n=3 Tax=cellular organisms
           RepID=Q2S5H3_SALRD
          Length = 186

 Score =  179 bits (454), Expect = 4e-44,   Method: Composition-based stats.
 Identities = 67/168 (39%), Positives = 96/168 (57%), Gaps = 17/168 (10%)

Query: 2   ISLIAALAV-DRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPG 56
           + +IAA+A  +RVIG +  +PW++P DL  FK+ T   P++MGR T+ESI    G PLP 
Sbjct: 21  LVIIAAVAEDNRVIGQDKDLPWHIPEDLKRFKQLTTGHPLLMGRRTFESIVHQFGGPLPD 80

Query: 57  RKNIILSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           RK ++L++Q   +    V    SVD A+AA  D   + + GG  VYEQFLP A +L LT 
Sbjct: 81  RKMVVLTTQDDYEAYPEVDTYASVDAALAALPDDATVFIGGGESVYEQFLPHADRLELTL 140

Query: 115 IDAEVEGDTHFPDYEP---DDWESVFSEFHDADAQNSHSYCFEILERR 159
           ++   EGDT FP +E    D +E         DA++   + F   ER+
Sbjct: 141 VEGAYEGDTFFPPFEHLIGDVFEET-----AVDARDG--FRFVTYERK 181


>UniRef50_Q59408 Dihydrofolate reductase type A13 n=57 Tax=Bacteria
           RepID=DYR13_ECOLX
          Length = 165

 Score =  179 bits (454), Expect = 4e-44,   Method: Composition-based stats.
 Identities = 55/160 (34%), Positives = 81/160 (50%), Gaps = 6/160 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I L+AA+  +RVIG    +PW +P +   F+R T +K V+MGR T+ESIG+PLP R  ++
Sbjct: 8   IYLVAAMGANRVIGNGPDIPWKIPGEQKIFRRLTESKVVVMGRKTFESIGKPLPNRHTVV 67

Query: 62  LSSQPGT-DDRVTWVKSVDEAI-AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           LS Q G        V ++     +      E+ V  G  VY   LP A  ++L+ +    
Sbjct: 68  LSRQAGYSAPGCAVVSTLSHVSPSTAEHGKELYVARGAEVYALALPHANGVFLSEVHQTF 127

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD  FP     ++E V SE      Q + +Y   +  RR
Sbjct: 128 EGDAFFPVLNAAEFEVVSSET----IQGTITYTHSVYARR 163


>UniRef50_UPI0001874368 dihydrofolate reductase n=1 Tax=Corynebacterium amycolatum SK46
           RepID=UPI0001874368
          Length = 176

 Score =  178 bits (452), Expect = 6e-44,   Method: Composition-based stats.
 Identities = 58/160 (36%), Positives = 77/160 (48%), Gaps = 4/160 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           + +I A +   +IG    MPW+LP DL  FK  T+  PVIMGR TW+S+    RPLPGR+
Sbjct: 15  VGMIWAQSRAGIIGDGATMPWHLPEDLQHFKTTTMGAPVIMGRRTWDSLNPKFRPLPGRR 74

Query: 59  NIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           NI+LS             S++ A+AA  D P   +IGGGRVY   L  A +  +T ID +
Sbjct: 75  NIVLSRSVSDFPGAESATSLEAALAAVADEPAAWIIGGGRVYRDALSLADECVVTDIDTD 134

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           V         +  DW  V              Y F   +R
Sbjct: 135 VSVPVPVMAPDLYDWVRVEDGPWQTSTT-GLRYRFCTWQR 173


>UniRef50_P00380 Dihydrofolate reductase n=1 Tax=Enterococcus faecium
           RepID=DYR_ENTFC
          Length = 167

 Score =  177 bits (450), Expect = 9e-44,   Method: Composition-based stats.
 Identities = 51/162 (31%), Positives = 92/162 (56%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKN 59
           M   + A   + +IG +  +PW LP D+ +F+ +T++K ++MGR T+E +G+  LP R  
Sbjct: 1   MFISMWAQDKNGLIGKDGLLPWRLPNDMRFFREHTMDKILVMGRKTYEGMGKLSLPYRHI 60

Query: 60  IILSSQPGT--DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+L++Q     +     + S+DE +A   D+PE I V GG R+++  LP+ + ++ T ID
Sbjct: 61  IVLTTQKDFKVEKNAEVLHSIDELLAYAKDIPEDIYVSGGSRIFQALLPETKIIWRTLID 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           AE EGDT   + +   +E V       + +N + + F+  ++
Sbjct: 121 AEFEGDTFIGEIDFTSFELVEEHEGIVNQENQYPHRFQKWQK 162


>UniRef50_Q13PE2 Dihydrofolate reductase n=1 Tax=Burkholderia xenovorans LB400
           RepID=Q13PE2_BURXL
          Length = 171

 Score =  177 bits (450), Expect = 1e-43,   Method: Composition-based stats.
 Identities = 61/157 (38%), Positives = 84/157 (53%), Gaps = 7/157 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + L+AA+A +RVIG+ N +PW +P +   F+  T+N+ V+MGR T+ESIG+PLPGR  ++
Sbjct: 7   VVLVAAMAANRVIGLGNDIPWRIPGEQKRFRELTMNQLVVMGRRTFESIGKPLPGRDLLV 66

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           LSS       V  VKS  E  AA  + P   I V GG +VY   +P A  +YLT ID   
Sbjct: 67  LSSGTSRLGTVRTVKSFAEVTAAVNNDPREAIFVGGGQQVYAMLMPYADVVYLTEIDLRP 126

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
            GD  FP+  P+ +    S            Y F   
Sbjct: 127 PGDAFFPEI-PERFSLPDSVDFPG----EIRYTFNTY 158


>UniRef50_C3XD45 Dihydrofolate reductase n=2 Tax=Oxalobacter formigenes
           RepID=C3XD45_OXAFO
          Length = 163

 Score =  176 bits (448), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 56/160 (35%), Positives = 89/160 (55%), Gaps = 7/160 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS + A+A +RVIG +  MPW++P +   F+  T+ K +I+GR T ESIGR LP R  II
Sbjct: 4   ISHVVAMAENRVIGKDGQMPWHIPGEQKIFRELTVGKALILGRKTHESIGRVLPDRITII 63

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +S +   +      V  +DEAI    +    +I++ GGG ++ Q LP   K+YL+ + A+
Sbjct: 64  VSRKKDYEVPGAHVVHDIDEAIRLAREFGKEDIVIGGGGELFSQTLPVTDKVYLSIVHAD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            +G+T +P+   +++     +  DA    S  Y F   ER
Sbjct: 124 FDGETFYPELPKEEFVEKARKEIDA----SIPYAFVEFER 159


>UniRef50_C3Z0P2 Putative uncharacterized protein n=2 Tax=Deuterostomia
           RepID=C3Z0P2_BRAFL
          Length = 185

 Score =  176 bits (448), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 53/179 (29%), Positives = 87/179 (48%), Gaps = 23/179 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51
           +SL+ A   +  IG++  +PW L  D+ +F R T           V+MGR TW SI    
Sbjct: 6   LSLVVAACNNMGIGVDGKIPWTLRGDMKFFSRLTSGTEEAGKQNAVVMGRKTWFSIPDRF 65

Query: 52  RPLPGRKNIILSSQPGTDDRV--TWVKSVDEAIAACGD------VPEIMVIGGGRVYEQF 103
           RPLP R N++LS    T          S++EA+    +      + ++ +IGG  VY+  
Sbjct: 66  RPLPKRLNVVLSRNLTTPPEGAHHLAGSLEEAVKMLTETTVADTIDKVFIIGGNSVYKDA 125

Query: 104 L--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVF--SEFHDADAQNSHSYCFEILER 158
           L  P   ++YLT +  +V  DT FP+ + D ++ V   +   +   +N   Y +E+ E+
Sbjct: 126 LSHPCCHRVYLTRVYKDVHCDTFFPNMD-DTFKLVSDPTIPSEMQEENGIEYKYEVYEK 183


>UniRef50_Q14P23 Putative dihydrofolate reductase oxidoreductase protein n=1
           Tax=Spiroplasma citri RepID=Q14P23_SPICI
          Length = 160

 Score =  176 bits (448), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 45/164 (27%), Positives = 81/164 (49%), Gaps = 12/164 (7%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI L+ A+  + +IG  + +PW+L  +L  FK  TL + ++ GR T+E IG PLP RK +
Sbjct: 1   MIKLLWAMDENNLIGQNDQLPWHLREELQHFKETTLGQTILFGRLTYEGIGWPLPKRKTL 60

Query: 61  ILSSQPGT---DDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           +L+           V  V  +   I         +I + GG ++YE  LP A +L ++ I
Sbjct: 61  VLTRHLDYQIKHPDVEVVTDLTAIINFYHQNPTEDIYICGGKKIYEATLPYADELIISLI 120

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
             + +GDT+FP ++ + +  +    +         +  +  +R+
Sbjct: 121 KGKYQGDTYFPSFDLNQFTLIKLNEYQQ-------FVIKYYKRK 157


>UniRef50_C5CC92 Dihydrofolate reductase n=3 Tax=Actinobacteria (class)
           RepID=C5CC92_MICLC
          Length = 186

 Score =  176 bits (448), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 62/176 (35%), Positives = 85/176 (48%), Gaps = 19/176 (10%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           +I++I A    RVIG +  MPW++P DLA F+ +T   PVIMGR TWES     RPLPGR
Sbjct: 11  VIAMIWAQTPGRVIGRDGTMPWHVPEDLAHFRAHTHGHPVIMGRRTWESFPARFRPLPGR 70

Query: 58  KNIILSSQPGTDD---------RVTWVKSV---DEAIAACGDVPEIMVIGGGRVYEQFLP 105
            NI++S      +             V        A A       + VIGG  +Y+Q L 
Sbjct: 71  TNIVVSRTLTATEQAGAQLRAAGAVVVPDFGAALAAAAEADGCDTVWVIGGATLYDQALD 130

Query: 106 KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHD---ADAQNSHSYCFEILER 158
            A +  +T IDA+V+GDTH P  +   W     +       D+ +   + FE  ER
Sbjct: 131 VASRAEVTVIDADVDGDTHAPPLDAR-WRRTAVDPAPDAWLDSASGPRHRFERWER 185


>UniRef50_B8DW85 Dihydrofolate reductase n=6 Tax=Bifidobacterium RepID=B8DW85_BIFA0
          Length = 227

 Score =  176 bits (448), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 64/181 (35%), Positives = 89/181 (49%), Gaps = 24/181 (13%)

Query: 2   ISLIAALAVD-----RVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RP 53
           ++LI A A D       IG E  MPW+LP DL  FK  T++ PVIMGR TWE++    RP
Sbjct: 37  VNLIWAQANDKEGRSGAIGYEGEMPWHLPEDLKRFKELTVSHPVIMGRKTWEALNEKFRP 96

Query: 54  LPGRKNIILSSQPGT-DDRVTWVKSVDEAIAACG---------DVPEIMVIGGGRVYEQF 103
           LP R NI+LS          T V +++EA+             D  EI VIGG +++ Q 
Sbjct: 97  LPNRDNIVLSRDRDFRAPGATVVDNLEEALDMARQEAIPDDGLDRSEIWVIGGSQLFNQM 156

Query: 104 LPKAQKLYLTHIDAEVEGDTHFPD----YEPDDWESVFSEFH--DADAQNSHSYCFEILE 157
           LP A K+Y+T +DA+V  D + PD         W+ + +         +    Y +   E
Sbjct: 157 LPMASKIYMTQVDAKVNADAYAPDLTEALNNGSWKLMENSGWLTPKKPEGIDRYRYLTFE 216

Query: 158 R 158
           R
Sbjct: 217 R 217


>UniRef50_UPI0001C35E5E dihydrofolate reductase region n=1 Tax=Clostridium hathewayi DSM
           13479 RepID=UPI0001C35E5E
          Length = 167

 Score =  176 bits (447), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 48/164 (29%), Positives = 78/164 (47%), Gaps = 8/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59
           +  I A+     IG +  +  +LP D+ +F+  T  K V+MGR T +S    +PL  R N
Sbjct: 1   MKAIVAVDEAWGIGKDGKLLTHLPEDMKFFRTVTKGKVVVMGRKTLQSFPDAKPLKNRIN 60

Query: 60  IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+L+S    + + +   +SV +A+      D  ++ +IGG  VYEQFLP     Y+T + 
Sbjct: 61  IVLTSDAALNGEGLIVCRSVADALRQLKEYDSDDVYIIGGQSVYEQFLPYCDTAYVTRMK 120

Query: 117 AEVEGDTHFPDYEPDD-WESVFSEFHDADAQNSHSYCFEILERR 159
            +   DT F + +  + WE    E  D        + F   + R
Sbjct: 121 RDFGADTWFVNLDRQEGWEET--ETGDEKEYEGLHFTFCTYKNR 162


>UniRef50_A7SCT0 Predicted protein n=2 Tax=Nematostella vectensis RepID=A7SCT0_NEMVE
          Length = 187

 Score =  176 bits (447), Expect = 3e-43,   Method: Composition-based stats.
 Identities = 48/178 (26%), Positives = 78/178 (43%), Gaps = 21/178 (11%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT-------LNKPVIMGRHTWESIG--- 51
            S I A+ + R IG  N +PW +  D+ +F   T           VIMGR  WESI    
Sbjct: 8   FSCIVAMDLKRGIGKNNDLPWKIKGDMKFFTEKTSEVKTEGKQNAVIMGRKVWESIPEKF 67

Query: 52  RPLPGRKNIILSSQPGTDD-RVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFL 104
           RPL GR NI+LS             +S ++A+           +  + V GG  +Y+  +
Sbjct: 68  RPLKGRLNIVLSRTLSEPPQGAQLCRSFEQALTILSTDPYTKKIENVFVCGGSALYKDAM 127

Query: 105 PK--AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDAD--AQNSHSYCFEILER 158
                 ++Y+T+ID E + D  FP+++ + +  V      +    +    Y F + +R
Sbjct: 128 AHSACTRIYITYIDQEFDCDVFFPEFDQNTYHLVEDPDVPSVQHEEKGIKYKFCVYDR 185


>UniRef50_B0VHY5 Dihydrofolate reductase n=1 Tax=Candidatus Cloacamonas
           acidaminovorans RepID=B0VHY5_9BACT
          Length = 141

 Score =  175 bits (446), Expect = 3e-43,   Method: Composition-based stats.
 Identities = 56/141 (39%), Positives = 81/141 (57%), Gaps = 4/141 (2%)

Query: 20  MPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD-RVTWVKSV 78
           MPW +  DL  FK  T+  PVIMG++TW SIG+PLPGR+NI+LS              S+
Sbjct: 1   MPWKITEDLKRFKAITMGHPVIMGKNTWNSIGKPLPGRQNIVLSKDRNFQPQGAIVAHSL 60

Query: 79  DEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFS 138
           +EA+       E  +IGG  V++QFLP A K+ +T I +E EGDT+FP +  +DW  +  
Sbjct: 61  EEALKMVEG-QEAYIIGGASVFKQFLPLADKMLITLIHSEFEGDTYFPYFSEEDW--ILQ 117

Query: 139 EFHDADAQNSHSYCFEILERR 159
           E     + + +  C +I  R+
Sbjct: 118 ESSSLLSSSGYELCLQIYIRK 138


>UniRef50_C2HC06 Dihydrofolate reductase n=11 Tax=Enterococcus faecium
           RepID=C2HC06_ENTFC
          Length = 172

 Score =  175 bits (446), Expect = 3e-43,   Method: Composition-based stats.
 Identities = 50/162 (30%), Positives = 91/162 (56%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKN 59
           M   + A   + +IG    +PW LP D+ +F+ +T+++ ++MGR T+E +G   LP R  
Sbjct: 1   MFISMWAQDRNGLIGKNGLLPWRLPNDMRFFREHTMDRILVMGRKTYEGMGDLSLPYRHI 60

Query: 60  IILSSQPG--TDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+L++QP   T +    + S+DE +A    +  +I V GG R++++ LP   +++ T ID
Sbjct: 61  IVLTTQPNFRTKENAEVMHSIDELLAYSQTISEDIYVSGGSRIFQELLPYTGRIWRTLID 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +  EGDT+  D +  D+  +       D +N +++ F+  ER
Sbjct: 121 STFEGDTYIGDIDFSDFALIEEYEGITDQENLYAHRFQKWER 162


>UniRef50_D2RRK6 Dihydrofolate reductase n=1 Tax=Haloterrigena turkmenica DSM 5511
           RepID=D2RRK6_9EURY
          Length = 181

 Score =  175 bits (446), Expect = 3e-43,   Method: Composition-based stats.
 Identities = 59/168 (35%), Positives = 83/168 (49%), Gaps = 20/168 (11%)

Query: 5   IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNI 60
           I A+A + VIG +  MPW++PADL  FK  T++ P+IMGR T+E I    G PLPGR  +
Sbjct: 19  IVAVADNGVIGKDGDMPWHIPADLKHFKETTMDHPIIMGRVTYEGILEALGEPLPGRTTV 78

Query: 61  IL-SSQPGTDDRVTWVKS--------VDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLY 111
           +L S    T +     +S           A         I V GG  VYEQFL    +L 
Sbjct: 79  VLTSRDLETPENAVTARSLEEALEAAETAARERHDAADRIFVAGGATVYEQFLSALDRLI 138

Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +T +  E +GDT+FPD++   ++ V  +  D        + F    RR
Sbjct: 139 VTEVHEEPDGDTYFPDWDRASFDDVSRDDRDG-------FAFVEYVRR 179


>UniRef50_Q9U8B8 Dihydrofolate reductase n=1 Tax=Heliothis virescens RepID=DYR_HELVI
          Length = 185

 Score =  175 bits (445), Expect = 4e-43,   Method: Composition-based stats.
 Identities = 54/179 (30%), Positives = 82/179 (45%), Gaps = 22/179 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51
           ++LIAA   +  IG+  A+PW L  ++A+F   T           VIMGR TW+ I    
Sbjct: 6   LNLIAAACDNMGIGVNGALPWRLKKEMAYFTTMTSKVSEPTKVNAVIMGRRTWDCIPDKY 65

Query: 52  RPLPGRKNIILSSQPGT-----DDRVTWVKSVDEAIAACGDVPEI---MVIGGGRVYEQF 103
           RPL  R NI+L+    +      + V     +DEAI       +I    VIGG  +Y   
Sbjct: 66  RPLQDRVNIVLTHNVDSVKENVPEGVMVFPGLDEAIKYIEGREDIESTWVIGGSSIYRAA 125

Query: 104 L--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF--HDADAQNSHSYCFEILER 158
           +  P   K+YLT I    + DT FP+ +   +  V  E    +   + + SY F + ++
Sbjct: 126 MTHPNCGKIYLTEIQKSFDCDTFFPNIDKQQFHLVDEEQIPGEKQVEGNISYYFRVYKK 184


>UniRef50_A3K5B9 Dihydrofolate reductase n=1 Tax=Sagittula stellata E-37
           RepID=A3K5B9_9RHOB
          Length = 153

 Score =  175 bits (444), Expect = 5e-43,   Method: Composition-based stats.
 Identities = 61/142 (42%), Positives = 82/142 (57%), Gaps = 7/142 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MI+LIAA   +R IG +  +PW++P DLA FKR TL   ++MGR TWES+  +PL  R N
Sbjct: 1   MITLIAAHDRNRAIGKDGDIPWHIPEDLAMFKRETLGGAIVMGRKTWESLPFKPLKDRLN 60

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           I++S      + V  V SV++AIA         I  IGG R+YE  LP A +L +T +D 
Sbjct: 61  IVVSRDTSLHEHV--VGSVEDAIALAQSQGYFRIYGIGGQRIYEAMLPLAHRLLITEVDT 118

Query: 118 EV-EGDTHFPDYEPDDWESVFS 138
            V E D  FPD   + W  V +
Sbjct: 119 VVEEADAFFPDVG-EGWREVST 139


>UniRef50_B0MRL8 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM
           15702 RepID=B0MRL8_9FIRM
          Length = 161

 Score =  174 bits (443), Expect = 7e-43,   Method: Composition-based stats.
 Identities = 49/161 (30%), Positives = 78/161 (48%), Gaps = 5/161 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           + +I A+  +  IG +  +  +L  DL   K  T+   ++MG  T+ S   RPLP R+N+
Sbjct: 1   MEIIVAVDENYGIGKDGDLLAHLSPDLKRLKAMTVGNIIVMGSKTYMSFPKRPLPDRENL 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++  P     +     VDE +       + I V+GGG VYEQ LP  +K ++T I    
Sbjct: 61  IITHHPENYPGIKCFTGVDEFLEYSKTADKPIFVLGGGSVYEQLLPYCEKAHITKILHSF 120

Query: 120 EGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCFEILERR 159
           E DT FP+ + + DWE    E      +  + + +    RR
Sbjct: 121 EADTFFPNLDNNPDWEKENEEDIVTGEK--YPFRYVTYVRR 159


>UniRef50_Q9CBW1 Dihydrofolate reductase n=25 Tax=Actinomycetales RepID=DYR_MYCLE
          Length = 165

 Score =  174 bits (443), Expect = 7e-43,   Method: Composition-based stats.
 Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 10/165 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           ++ LI A +   VIG +  MPW +P DL  FK+ T+  PV+MGR TW+S+    RPLPGR
Sbjct: 3   VVGLIWAQSTTGVIGRDGGMPWRVPEDLTRFKQLTMGHPVVMGRRTWDSLPVGVRPLPGR 62

Query: 58  KNIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +NI+LS Q     +      S++E I+     PE+ VIGG ++Y   LP A +  +T +D
Sbjct: 63  RNIVLSRQIDFMAEGAEVFGSLEETISNLETEPEMWVIGGEQIYRLALPLATRCGVTEVD 122

Query: 117 AEV---EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             +   + D   P  + D W  V  E+  + +     Y      R
Sbjct: 123 TYLLHEDDDVLAPVLD-DTWVGVTGEWLVSCS--GLRYRLHSYHR 164


>UniRef50_D2Q8R3 DfrA Dihydrofolate reductase n=12 Tax=Bifidobacterium
           RepID=D2Q8R3_9BIFI
          Length = 224

 Score =  174 bits (442), Expect = 1e-42,   Method: Composition-based stats.
 Identities = 62/182 (34%), Positives = 84/182 (46%), Gaps = 25/182 (13%)

Query: 2   ISLIAALAVD-----RVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RP 53
           ++LI A A D       IG E  MPW LP D+  F   T++ PVIMGR TWE++    RP
Sbjct: 39  VNLIWAQARDKEGRDGAIGFEGGMPWRLPEDMKHFTELTVSHPVIMGRRTWEALSPKFRP 98

Query: 54  LPGRKNIILSSQPGT-DDRVTWVKSVDEAIAACG---------DVPEIMVIGGGRVYEQF 103
           LP R NI++S  P       T V ++D+A+             D  EI +IGG +V+   
Sbjct: 99  LPNRDNIVISHDPAYSAPGATVVDTLDDALDLARQEAIPDDGLDRSEIWIIGGAQVFRDA 158

Query: 104 LPKAQKLYLTHIDAEVEGDTHFPDY----EPDDWESVFSEFHDADAQNSHS---YCFEIL 156
           LP A K Y+T I   V+ DT+ PD     E   W            + S     + F   
Sbjct: 159 LPFADKAYVTQISMHVDADTYAPDIASLAESGAWRMAEEGVWQGTQKGSDDIAGFRFVTY 218

Query: 157 ER 158
           E+
Sbjct: 219 EK 220


>UniRef50_A5WHY1 Dihydrofolate reductase n=4 Tax=Moraxellaceae RepID=A5WHY1_PSYWF
          Length = 193

 Score =  174 bits (441), Expect = 1e-42,   Method: Composition-based stats.
 Identities = 56/179 (31%), Positives = 89/179 (49%), Gaps = 28/179 (15%)

Query: 5   IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKP-----------VIMGRHTWESIG-R 52
           I A++ +R IG  N +PW++P DL  FK  T  +            VIMGR T+ES+G +
Sbjct: 11  IVAISRNRCIGKGNDLPWHIPNDLKHFKAMTTAETDAYVDTGLKGIVIMGRKTFESMGSK 70

Query: 53  PLPGRKNIILSSQPGTDD--------RVTWVKSVDEAIAACGDV------PEIMVIGGGR 98
           PLP R N I+++Q              V  V ++D+A+    +V        I VIGG R
Sbjct: 71  PLPKRVNFIVTTQMDYAQQKGLEGLKDVHVVHNLDDALTHAANVAHGLKFETIWVIGGER 130

Query: 99  VYEQFLPKAQKLYLTHIDAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
           V+++ +    ++ LT +D ++E GD  +P+  P+D+E         D ++  SY F   
Sbjct: 131 VFKRAMMFTDRIELTVVDTDIEDGDAFYPEI-PEDFELTQESESFTDEKSGLSYKFMTY 188


>UniRef50_A1WYQ0 Dihydrofolate reductase n=1 Tax=Halorhodospira halophila SL1
           RepID=A1WYQ0_HALHL
          Length = 164

 Score =  174 bits (441), Expect = 1e-42,   Method: Composition-based stats.
 Identities = 60/161 (37%), Positives = 80/161 (49%), Gaps = 8/161 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I L+A +  + VIG +   PW+   DL  FK  T   PVIMGR T  +IGRPLP R NI+
Sbjct: 4   IVLVAIVGRNGVIGADGDQPWHFRCDLQRFKALTRGHPVIMGRRTLAAIGRPLPQRTNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVD---EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           L+  PG   D V      +      A       +M++GGG VY  FLP+A +L LT +D 
Sbjct: 64  LTRDPGFHADGVEVATDPEAALARAAESAGGERVMILGGGDVYRLFLPRAHRLALTEVDD 123

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              GDT FP   P +W+    E      ++ +   F  L R
Sbjct: 124 APPGDTTFPAIGP-EWQETAREE---AEEDGYRLTFRTLLR 160


>UniRef50_C0QWN0 Dihydrofolate reductase n=2 Tax=Brachyspira RepID=C0QWN0_BRAHW
          Length = 166

 Score =  173 bits (440), Expect = 2e-42,   Method: Composition-based stats.
 Identities = 56/167 (33%), Positives = 90/167 (53%), Gaps = 12/167 (7%)

Query: 1   MISLIAALAVDRVIGMENAMPW-NLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRK 58
           ++SLIAA+     IG+   MPW ++  D+ +F+  T    VIMGR T+ES+G +PLP RK
Sbjct: 2   IVSLIAAVDSKNGIGLNGVMPWGHIKEDMQFFRSTTTGYAVIMGRVTFESLGSKPLPNRK 61

Query: 59  NIILSSQPGTD-----DRVTWVKSVDEAIA--ACGDVPEIMVIGGGRVYEQFLPKAQKLY 111
           NI++SS   T+     D + + KS +++I+        +I +IGG  +Y++ L  A  +Y
Sbjct: 62  NIVISSNVNTELLNKYDNLFYEKSFEDSISKLLLEKNKQIFIIGGESIYKKALDYADMIY 121

Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           LTHID +   D  FP+ + + ++S   +       N  S       R
Sbjct: 122 LTHIDKDYHCDRFFPEIDTNLFQSDELKTFFY---NDISVNIIKYTR 165


>UniRef50_Q3A0W8 Dihydrofolate reductase n=1 Tax=Pelobacter carbinolicus DSM 2380
           RepID=Q3A0W8_PELCD
          Length = 167

 Score =  172 bits (437), Expect = 3e-42,   Method: Composition-based stats.
 Identities = 54/159 (33%), Positives = 82/159 (51%), Gaps = 8/159 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++++ A+  +R+IG    +PW++P DLA F+R T    ++MGR T+ESIGRPLPGR NI+
Sbjct: 16  MTIVVAMTAERIIGRRGQLPWSIPEDLALFRRLTYGHTLVMGRRTFESIGRPLPGRFNIV 75

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S      + +   +   EA+        +I  IGG  +Y Q L  A KL ++ I     
Sbjct: 76  VSRSMPPVEGLRVCRHFAEALQVADQGNGDIFFIGGCEIYRQALIVAGKLSVSWIRKNYP 135

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GD  FP+Y  DDW     + +         +   I  RR
Sbjct: 136 GDCRFPEYRSDDWLIEQEQDYSE-------FRHIIYRRR 167


>UniRef50_C7H0N2 Dihydrofolate reductase n=1 Tax=Eubacterium saphenum ATCC 49989
           RepID=C7H0N2_9FIRM
          Length = 162

 Score =  172 bits (436), Expect = 4e-42,   Method: Composition-based stats.
 Identities = 49/162 (30%), Positives = 79/162 (48%), Gaps = 6/162 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59
           ++ I  +  +  IG +  +  +L  DL +FK  T+ K +I+GR T ES    +PLPGRK 
Sbjct: 1   MNAIVVVDKNWCIGKDGGLLVHLSKDLKYFKEKTIGKTLIVGRKTLESFPGGKPLPGRKT 60

Query: 60  IILSSQPGT-DDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+L+       +      S  E +    D+   ++ V GGG +Y+QFL    K ++T I 
Sbjct: 61  IVLTRNTSYKAEGAYVCHSKQEVLEKVKDLHPADVFVAGGGAIYKQFLNDVDKGFVTKIC 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            E  GDT FP+ + D+ +       +   +N   + F I  R
Sbjct: 121 NEYSGDTFFPNLDEDE-DFALESEGETIEENGVKFKFCIYNR 161


>UniRef50_C4Z7Z2 Dihydrofolate reductase n=34 Tax=Bacteria RepID=C4Z7Z2_EUBR3
          Length = 163

 Score =  171 bits (435), Expect = 5e-42,   Method: Composition-based stats.
 Identities = 49/165 (29%), Positives = 83/165 (50%), Gaps = 12/165 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59
           ++LIAA+  +  IG  N +   +P D  +F+  T  K V+MGR T ES    RPL  R N
Sbjct: 1   MNLIAAVDNNWAIGKNNQLLVRIPMDQKFFREMTTGKVVVMGRKTLESFPNSRPLKNRTN 60

Query: 60  IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+L+  P  + +    V S+DE        +  +I +IGG ++YEQ + +    ++T +D
Sbjct: 61  IVLTHNPSYEVEGAVVVHSLDELHKELEKYNSEDIYIIGGQKIYEQLVDECDVAHITKVD 120

Query: 117 AEVEGDTHFPDYEPD-DWESVFSEFHDADAQNSHS--YCFEILER 158
            E + D +FP+ +   +W+       D++ Q      + F   E+
Sbjct: 121 FEYDADAYFPNLDEKPEWQIT----GDSEEQTYFDLEFYFLRYEK 161


>UniRef50_C1C2C0 Dihydrofolate reductase n=1 Tax=Caligus clemensi RepID=C1C2C0_9MAXI
          Length = 178

 Score =  171 bits (434), Expect = 7e-42,   Method: Composition-based stats.
 Identities = 52/168 (30%), Positives = 86/168 (51%), Gaps = 14/168 (8%)

Query: 2   ISLIAALAVD-RVIGMENAMPWNLPADLAWFKRNTLNKP-----VIMGRHTWESIG---R 52
           I++IAA     R IG +N +PW LP D+ +F+  T +       VIMGR TWES+    R
Sbjct: 9   INVIAAACKSSRGIGKDNDLPWKLPTDMKYFREKTASTTEIRVGVIMGRRTWESVPPKFR 68

Query: 53  PLPGRKNIILSSQPGTDD-RVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLP-KAQK 109
           P   R N++L+S+   +       +++++A+  C  +V  I VIGG  VY + L     +
Sbjct: 69  PFKNRFNVVLTSREDFEAKGAVIARTLEDAVKKCSNNVDSIWVIGGSGVYAEALNKYPCR 128

Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
           +YLT ID E + D  FP  +   ++           +N  ++ F++ +
Sbjct: 129 VYLTEIDKEFDCDAFFPPLDEKKYKLAS--VSPDHQENDITFRFKVYD 174


>UniRef50_C7N8V9 Dihydrofolate reductase region n=5 Tax=Fusobacteriaceae
           RepID=C7N8V9_LEPBD
          Length = 173

 Score =  171 bits (434), Expect = 7e-42,   Method: Composition-based stats.
 Identities = 54/177 (30%), Positives = 94/177 (53%), Gaps = 26/177 (14%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M SLI A+  +  IG  N + W++P DL  FK+ T+ K VIMG++T++SIG+PLP RKNI
Sbjct: 1   MFSLIVAVGENNEIGKNNQLLWHIPEDLKNFKKITMGKTVIMGKNTYKSIGKPLPNRKNI 60

Query: 61  ILSSQP---------------GTDDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQF- 103
           +LS  P                 + ++    ++ + I    +   EI +IGGG +Y++  
Sbjct: 61  VLSRNPLEIEEKIKEDRKKYENENTKLELCDNLQKIIDKYKNSEEEIFIIGGGEIYKKAF 120

Query: 104 -LPKAQKLYLTHID-AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            +   +++Y++H++ ++   DT+FP  +   W  +  E +D        + F I E+
Sbjct: 121 EMKIVKRIYMSHVNFSDKNADTYFPKIDLKKWVVITKENYDG-------WRFCIYEK 170


>UniRef50_Q59487 Dihydrofolate reductase n=17 Tax=Streptococcaceae RepID=DYR_LACLA
          Length = 168

 Score =  171 bits (434), Expect = 7e-42,   Method: Composition-based stats.
 Identities = 51/164 (31%), Positives = 89/164 (54%), Gaps = 6/164 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59
           MI  I A     +IG  + MPW+LPA+   FK  T+N+ ++MGR T+E +  R LPGR +
Sbjct: 1   MIIGIWAEDEAGLIGEADKMPWSLPAEQQHFKETTMNQVILMGRKTFEGMNKRVLPGRIS 60

Query: 60  IILSSQPGT---DDRVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           IIL+        +++V  + S  E +        ++ + GG  +   F  + + LY T +
Sbjct: 61  IILTRDETYQSDNEKVLIMHSPKEVLDWYHKQNKDLFITGGAEILALFESELELLYRTVV 120

Query: 116 DAEVEGDTHFPD-YEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             + +GDT+FP  ++   ++ V  +FHD D +NS+++  +  E+
Sbjct: 121 HEKFKGDTYFPSTFDFGRFKLVSEKFHDKDERNSYTFTIKKYEK 164


>UniRef50_B7C7C2 Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM
           3989 RepID=B7C7C2_9FIRM
          Length = 159

 Score =  171 bits (434), Expect = 8e-42,   Method: Composition-based stats.
 Identities = 49/157 (31%), Positives = 83/157 (52%), Gaps = 5/157 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LIAA+  +R +G  N M W+LP DL +F++ T    ++MGR T+ES+   LP R +++
Sbjct: 3   LTLIAAIGKNRELGKNNDMIWHLPQDLKFFRQETSGHTIVMGRKTFESLPGKLPKRHHVV 62

Query: 62  LSSQ-PGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +S       + +   +SV+E +    DV  EI  IGGG +Y + L  A +L LT IDA+ 
Sbjct: 63  ISRTCKDLGEDIEMCESVEEFMKRYKDVDEEIYCIGGGMIYSEMLKYASRLVLTQIDADA 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
           + + +FP+++   +            +N   Y     
Sbjct: 123 DAEVYFPEFDESLYNKKILSNI---EENGVFYQHVEY 156


>UniRef50_B4D395 Dihydrofolate reductase region n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4D395_9BACT
          Length = 201

 Score =  170 bits (433), Expect = 9e-42,   Method: Composition-based stats.
 Identities = 58/189 (30%), Positives = 89/189 (47%), Gaps = 45/189 (23%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQP- 66
           ++++RVIG +N +PW+LP D  WFK+ T    V+MGR T+ES+GRPLP R NI+++ +P 
Sbjct: 1   MSLNRVIGRDNKIPWHLPEDFKWFKKLTTGHFVLMGRKTFESLGRPLPNRTNIVVTRKPL 60

Query: 67  ----------------------------------GTDDRVTWVKS---VDEAIAACGDVP 89
                                              ++  V  V+    + +A        
Sbjct: 61  RLARDPQFKATVGQARVGHWQARFGRPYQLGFERLSERDVWLVRDPRKLADAFEKARPSR 120

Query: 90  EIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSH 149
           ++ VIGG ++YEQ LP+   LYL+ +  EVEGD  FP+ E DDW    +     D     
Sbjct: 121 QLFVIGGAQIYEQLLPRCTDLYLSVVQREVEGDACFPELE-DDWYLHDTPLRTPD----- 174

Query: 150 SYCFEILER 158
            +  +   R
Sbjct: 175 -FEVQHYRR 182


>UniRef50_C5BYZ5 Dihydrofolate reductase n=1 Tax=Beutenbergia cavernae DSM 12333
           RepID=C5BYZ5_BEUC1
          Length = 169

 Score =  169 bits (428), Expect = 4e-41,   Method: Composition-based stats.
 Identities = 51/143 (35%), Positives = 78/143 (54%), Gaps = 10/143 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           MI +I A A D VIG    +PW++P D A FK  T    V+MGR TW+S+    RP+P R
Sbjct: 1   MIGMIWAQAHDGVIGARGTVPWHVPEDFAHFKATTRGHAVVMGRATWDSLPDRYRPMPER 60

Query: 58  KNIILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +N++++ Q   + D      S+ +A+  C   PE  ++GG ++Y + +P A  L +T +D
Sbjct: 61  RNVVVTRQVDWSADGAERAGSIPDALERCAAEPETWIMGGAQIYAEAMPYADTLVVTQLD 120

Query: 117 --AEVEGD---THFPDYEPDDWE 134
              +VEG     H P   P +W 
Sbjct: 121 LALDVEGAPDVVHAPPIGP-EWR 142


>UniRef50_C9KQJ5 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
           n=2 Tax=Veillonellaceae RepID=C9KQJ5_9FIRM
          Length = 342

 Score =  168 bits (427), Expect = 4e-41,   Method: Composition-based stats.
 Identities = 50/164 (30%), Positives = 73/164 (44%), Gaps = 17/164 (10%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59
           +S+IA +   R IG    +  +LP D+  F+  T    VIMGR T ES+   RPL  R+N
Sbjct: 168 LSMIACIDEGRGIGYRGELLVHLPEDMKHFRALTEGHVVIMGRRTMESLPGKRPLVNRQN 227

Query: 60  IILSSQPGTDDRVTWVKSVDEA------IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           I+LS Q    +      S+ +       + A     ++  IGG  +Y   LP A ++ LT
Sbjct: 228 IVLSRQLEGAEGFLICHSLPDLWRALGRLRAEKPQRKLWCIGGEELYRALLPYAHEVCLT 287

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
            + A    D  FP  +  D+  V     D D +      FE  E
Sbjct: 288 RLKAVYPADCFFPPLD--DFSLV-----DTDDREGL--VFERYE 322


>UniRef50_D1YEK5 Dihydrofolate reductase n=3 Tax=Propionibacterium acnes
           RepID=D1YEK5_PROAC
          Length = 156

 Score =  168 bits (427), Expect = 5e-41,   Method: Composition-based stats.
 Identities = 49/161 (30%), Positives = 74/161 (45%), Gaps = 11/161 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +  IAA+A + VIG    M W++  D   FK  T+   +I GR T+E IG+ LPGR++II
Sbjct: 3   VVAIAAVADNGVIGSGQDMLWHISEDFRRFKTVTMGHTLIFGRRTFEQIGK-LPGRRHII 61

Query: 62  LSSQP-GTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
            +  P  + + V    S  +A+    +  E    V GGG++Y        +L +T +   
Sbjct: 62  CTRDPHWSHEGVDVATSPRQAVEMAREAGEEICFVAGGGQIYADTFELCDELDITEVHQN 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
             G   FP  +P+ W  V  E  D        + F    RR
Sbjct: 122 PNGAARFPAIDPEVWVEVRRESRDG-------FDFVGYRRR 155


>UniRef50_UPI000186EC32 Dihydrofolate reductase, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186EC32
          Length = 190

 Score =  168 bits (426), Expect = 6e-41,   Method: Composition-based stats.
 Identities = 54/177 (30%), Positives = 80/177 (45%), Gaps = 20/177 (11%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51
            +LIAA+  +  IG +  +PWNL  +L +F R T +         VIMGR TW+S+    
Sbjct: 5   FNLIAAVCSNNGIGYKGNLPWNLRKELQYFNRMTKDVKNPEKKNAVIMGRKTWDSLPHNW 64

Query: 52  RPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLP 105
           +PLPGR N +L++Q    D       +++ I           +    VIGG +VYE  L 
Sbjct: 65  KPLPGRYNFVLTTQSLNLDGAVVCSDLNDLIKKINSPDYSNLIETAWVIGGSKVYESVLK 124

Query: 106 K--AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDA--DAQNSHSYCFEILER 158
                + YLT I  E E D  F      D++ V  +        +N   Y F + E+
Sbjct: 125 YGLCHRFYLTRIKKEFECDCFFNYDFTKDFKEVSDDRVPKGVQKENEIEYVFHVYEK 181


>UniRef50_B9DU71 Dihydrofolate reductase n=13 Tax=Streptococcus RepID=B9DU71_STRU0
          Length = 165

 Score =  167 bits (425), Expect = 7e-41,   Method: Composition-based stats.
 Identities = 48/161 (29%), Positives = 80/161 (49%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKNI 60
           I  I A   + VIG    +PW LP +L  FK  TLN  ++MGR T+E + R  LP R+ +
Sbjct: 5   IIAIWAEDENGVIGANGTLPWYLPKELQHFKNTTLNHAILMGRVTFEGMKRRLLPNRQTL 64

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +L+S      D    + S+++ +         + VIGG +V + F     K+  T +  +
Sbjct: 65  VLTSDESYHVDGALTMTSLEKTLEWYHAQENNLYVIGGQKVLQTFDGHFNKIIKTVVHHQ 124

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +GDT+ P+ +   +      F++ D QN + +   IL R+
Sbjct: 125 FDGDTYRPELDLSPFVEEDCFFYERDDQNPYDFTVHILVRK 165


>UniRef50_C7XU42 Dihydrofolate reductase n=1 Tax=Lactobacillus coleohominis
           101-4-CHN RepID=C7XU42_9LACO
          Length = 166

 Score =  167 bits (425), Expect = 9e-41,   Method: Composition-based stats.
 Identities = 46/159 (28%), Positives = 72/159 (45%), Gaps = 4/159 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS + A      IG    +PW+LP DL  FK  T + P++MG  T+ SIGRPLP R NI+
Sbjct: 3   ISFVWAEDEAGWIGKNGQLPWHLPVDLKHFKTVTDHHPIVMGARTFASIGRPLPNRPNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAA----CGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +S  P   D+V  V ++++ +        D  E+ +IGG  ++ Q +     L+ T +  
Sbjct: 63  VSHHPVAVDQVITVTNIEDLMNLIFKRYADQEEVCIIGGAGLFAQMVAHVNCLHRTIVMG 122

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
              GD      +   W+             + +  FE  
Sbjct: 123 NHHGDVKMIPIDYHQWQLTKKTPVYNSKTGALNCYFEEW 161


>UniRef50_C4WVU0 ACYPI002804 protein n=1 Tax=Acyrthosiphon pisum RepID=C4WVU0_ACYPI
          Length = 184

 Score =  167 bits (424), Expect = 1e-40,   Method: Composition-based stats.
 Identities = 50/174 (28%), Positives = 85/174 (48%), Gaps = 18/174 (10%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL-------NKPVIMGRHTWESIG---R 52
           S+IAA++ +  IG +  +PW +  ++ +F   T           VIMGR TW+SI    R
Sbjct: 10  SVIAAVSKNGGIGYKGNLPWKIKKEMEYFNLMTTRVNLKGVQNAVIMGRCTWQSIPDKYR 69

Query: 53  PLPGRKNIILSSQPGT-DDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLP--K 106
           PL GR N+++S    +  + V     ++EA+ +      +  + VIGG  +Y++ +    
Sbjct: 70  PLKGRINVVISKTLNSVPEGVLLYPKLEEALKSLYLNDRIENLWVIGGSGLYKEAVNDKN 129

Query: 107 AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDA--DAQNSHSYCFEILER 158
            +KL++T ID E   DT FPD++   +E              N   Y F++ +R
Sbjct: 130 CKKLFITKIDQEYLCDTFFPDFDTKKFEETSEANVPKGIQEDNGIKYEFKVFKR 183


>UniRef50_C7R3F1 Dihydrofolate reductase n=1 Tax=Jonesia denitrificans DSM 20603
           RepID=C7R3F1_JONDD
          Length = 191

 Score =  167 bits (424), Expect = 1e-40,   Method: Composition-based stats.
 Identities = 56/164 (34%), Positives = 79/164 (48%), Gaps = 10/164 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           +SLI A +++ VIG    +PW+ P DLA F++ T    VIMGRHTWES+   PLP R NI
Sbjct: 11  LSLIWAQSLNGVIGRSGTIPWHEPTDLAHFQKTTRGGVVIMGRHTWESLPVTPLPQRVNI 70

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACG-----DVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +L+S           V +  +A+             I VIGG +VY+ F+  A +L +T 
Sbjct: 71  VLTSDRDYRAPGARVVTTPQQALDLAHWYTQVGHQAIWVIGGRQVYDTFMDYATQLIVTT 130

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +   +EGDT  P   P     V  E H     + +        R
Sbjct: 131 VGTVIEGDTEAPRIPP---HFVPQEPHQLATHSDYEVTVTTWLR 171


>UniRef50_C8NZB9 Dihydrofolate reductase n=1 Tax=Erysipelothrix rhusiopathiae ATCC
           19414 RepID=C8NZB9_ERYRH
          Length = 150

 Score =  167 bits (423), Expect = 1e-40,   Method: Composition-based stats.
 Identities = 44/158 (27%), Positives = 83/158 (52%), Gaps = 9/158 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI +I A+   R IG+  +MPW+   DL  F+++TLN+ V+MGR T+E + + L  R+  
Sbjct: 1   MIKIIVAMNNHRTIGLNGSMPWHNKEDLQHFRKSTLNQKVVMGRKTFEGLPKKLDNREIY 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +++     ++ +  +++    +       +I + GGG +Y Q LP A +L +++I  +V 
Sbjct: 61  VVTRNASIENAIPDLRAF--LMQHKESSEDIFIAGGGEIYAQSLPFAHELIISYIPNDVI 118

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT FPD+   +++      +        ++     ER
Sbjct: 119 GDTFFPDFSDLEFKIKNQVEYS-------TFKQVTYER 149


>UniRef50_Q0G0R9 Dihydrofolate reductase n=2 Tax=Aurantimonadaceae
           RepID=Q0G0R9_9RHIZ
          Length = 178

 Score =  167 bits (423), Expect = 1e-40,   Method: Composition-based stats.
 Identities = 54/165 (32%), Positives = 84/165 (50%), Gaps = 7/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
              + A A + VIG +  MPW++P+DL  ++  T+ KP+IMGR T E+IG+ L GR +I+
Sbjct: 8   FVAVVAAAKNGVIGADGGMPWSIPSDLKRYRSLTMGKPMIMGRKTLEAIGKALDGRDSIV 67

Query: 62  LSS-QPGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           L+       D         EAIA   +        EI V+GG  +Y        ++ LT 
Sbjct: 68  LTRENRLAVDGAMLASGPAEAIAKAIECASARRASEIAVVGGAEIYRLLWDHIDRIALTE 127

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +DAE EGD  FP  +  ++E +  E      ++S +  F+  +RR
Sbjct: 128 VDAEPEGDAVFPAIDESEFELLSEEPWIRGERDSAATRFKSYQRR 172


>UniRef50_Q8JKV3 Dihydrofolate reductase n=1 Tax=Heliothis zea virus 1
           RepID=Q8JKV3_9VIRU
          Length = 264

 Score =  167 bits (423), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 60/174 (34%), Positives = 88/174 (50%), Gaps = 18/174 (10%)

Query: 2   ISLIAALAVDR-VIGMENAMPWNLPADLAWFKRNTL------NKPVIMGRHTWESIG--- 51
           I+LI A+  +   IGM NA+PW+L  ++A F + T          VIMGR TWESI    
Sbjct: 87  INLIVAVCENNMGIGMNNALPWHLKREMAHFTKTTTTATHPNKNAVIMGRLTWESIPKRF 146

Query: 52  RPLPGRKNIILSSQP-GTDDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFL--P 105
           RPLPGR NI+L+++  G  D  T V + DEAI      GD+    VIGG  VY   +  P
Sbjct: 147 RPLPGRVNIVLTTKHRGDYDGATRVSNFDEAIRVVESRGDIETAWVIGGASVYAAAMTHP 206

Query: 106 KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
              +++LT I    E +  FP  +   +E +         +    Y +++ ++R
Sbjct: 207 NCHQIHLTAIKKYYECNVFFPKIDTTRFELISET--PCTREGDVQYSYKVYQQR 258


>UniRef50_P17719 Dihydrofolate reductase n=21 Tax=Endopterygota RepID=DYR_DROME
          Length = 182

 Score =  166 bits (422), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 51/178 (28%), Positives = 85/178 (47%), Gaps = 22/178 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRN-------TLNKPVIMGRHTWESIG--- 51
            +LI A+  +  IG+   +PW + ++L +F R        T    V+MGR T+  +    
Sbjct: 4   FNLIVAVCENFGIGIRGDLPWRIKSELKYFSRTTKRTSDPTKQNAVVMGRKTYFGVPESK 63

Query: 52  RPLPGRKNIILSSQPGTDD---RVTWVKSVDEA---IAACGDVPEIMVIGGGRVYEQFL- 104
           RPLP R NI+LS+     D    V    +++ A   +    +V  I ++GG  VYE+ + 
Sbjct: 64  RPLPDRLNIVLSTTLQESDLPKGVLLCPNLETAMKILEEQNEVENIWIVGGSGVYEEAMA 123

Query: 105 -PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESV---FSEFHDADAQNSHSYCFEILER 158
            P+  +LY+T I  + + DT FP   PD +  V            +N   + ++ILE+
Sbjct: 124 SPRCHRLYITKIMQKFDCDTFFPAI-PDSFREVAPDSDMPLGVQEENGIKFEYKILEK 180


>UniRef50_B3RI81 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3RI81_TRIAD
          Length = 174

 Score =  166 bits (422), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 55/174 (31%), Positives = 85/174 (48%), Gaps = 24/174 (13%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG---RPLPGR 57
           +  DR IG +N +PW L  +  +F R T +         V+MGR+TW SI    RPL  R
Sbjct: 1   MTRDRGIGYKNDLPWKLRNEYKYFARLTTSTKDSAKKNAVLMGRNTWVSIPEKNRPLRNR 60

Query: 58  KNIILSSQPGTDD---RVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFL--PK 106
            NI++SSQ   ++    V  V S+ E I           V  + ++GG  VY+ F+  P+
Sbjct: 61  INIVISSQLRAEEVPEGVHVVASIPEVIELVQSPLLKDIVETVWIVGGAPVYKGFMSHPQ 120

Query: 107 AQKLYLTHIDAEVEGDTHFPDYEPDDWESVF--SEFHDADAQNSHSYCFEILER 158
             ++YLT +DA  E D  FP+   DD++ +       +   +N   Y F + +R
Sbjct: 121 CDRIYLTKLDANYECDVFFPEMS-DDFKEISDPDVSQEVQEENGLKYTFHVYQR 173


>UniRef50_C8WAC3 Dihydrofolate reductase region n=5 Tax=Coriobacteriaceae
           RepID=C8WAC3_ATOPD
          Length = 162

 Score =  165 bits (418), Expect = 6e-40,   Method: Composition-based stats.
 Identities = 46/161 (28%), Positives = 77/161 (47%), Gaps = 6/161 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           ++ I ++  D  IG +  +     AD+ +F  +T +  VIMGR T ES    PL GR+NI
Sbjct: 1   MNAIVSVTRDWGIGCDGDLLIPNKADMKYFVEHTRSCTVIMGRKTLESFPGGPLKGRRNI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           ++S       + V  V S +EA+    D    ++ +IGG  +Y   L +    Y+T  D 
Sbjct: 61  VISRNTNYQVEGVEIVSSAEEALRLVKDEAPEKVWLIGGASIYRALLDRCSYAYVTKHDT 120

Query: 118 EVEGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCFEILE 157
            V+ DT+FP+ + D  W+    E      +   ++ F   +
Sbjct: 121 VVDADTYFPNLDEDPAWKVCNEEDGGVTPE-GVAFKFVTYQ 160


>UniRef50_Q7VQK5 Dihydrofolate reductase type I n=1 Tax=Candidatus Blochmannia
           floridanus RepID=Q7VQK5_BLOFL
          Length = 168

 Score =  165 bits (418), Expect = 6e-40,   Method: Composition-based stats.
 Identities = 63/166 (37%), Positives = 95/166 (57%), Gaps = 8/166 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           +ISLIAA  ++ VIG +N +PW    D+ WFK +T+ KPVIMGR T+ES+  +PLP R N
Sbjct: 2   IISLIAAFTINYVIGRKNIIPWYFSWDMMWFKYHTMYKPVIMGRKTFESMNSKPLPYRLN 61

Query: 60  IILSSQP----GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           I+LS            +    +  +A++      E+M+IGGG VY  F+ +  ++YLT I
Sbjct: 62  IVLSKHHILYNNKIHNIFIACNPIQALSVVQKNDEVMIIGGGLVYNAFMSQCTRMYLTKI 121

Query: 116 DAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSY--CFEILER 158
           D     GD+ FP Y P++W  V++          ++Y   F+IL+R
Sbjct: 122 DVVYNYGDSWFPSYNPNEWCVVYNTNKKCVINTGYTYNLNFQILDR 167


>UniRef50_C0EGY7 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum
           DSM 5476 RepID=C0EGY7_9CLOT
          Length = 319

 Score =  165 bits (418), Expect = 6e-40,   Method: Composition-based stats.
 Identities = 55/168 (32%), Positives = 85/168 (50%), Gaps = 12/168 (7%)

Query: 1   MISL--IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPG 56
           MI +  I A+     IG EN + +++P D+A+F++ TLNK V+MGRHT ES+   RPL  
Sbjct: 1   MIKMKCIVAVDQAWGIGCENGLLYSIPEDMAFFRKTTLNKAVVMGRHTLESLPKSRPLKN 60

Query: 57  RKNIILSSQPGTDD-RVTWVKSVDE---AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112
           R NI++S              S+ +   A++ C D  ++ V+GG  VY   L    +  +
Sbjct: 61  RLNIVMSRDRSLQIGGAITCCSLQDLGVALSIC-DSDDVYVMGGYAVYSLLLDFCGQALI 119

Query: 113 THIDAEVEGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCFEILERR 159
           T I  + E D  FP+ + D +W    SE  D  + N   Y F +   +
Sbjct: 120 TKIQGQREADRFFPNIDRDNNW--TLSEQSDVRSHNGLCYSFCVYANK 165


>UniRef50_UPI0001926A4C PREDICTED: similar to Dihydrofolate reductase CG14887-PB n=1
           Tax=Hydra magnipapillata RepID=UPI0001926A4C
          Length = 189

 Score =  165 bits (418), Expect = 6e-40,   Method: Composition-based stats.
 Identities = 56/177 (31%), Positives = 86/177 (48%), Gaps = 22/177 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL-------NKPVIMGRHTWESIG--- 51
           +  IAA+  +  IG++  +PWNLP +  +F+  T           VIMG++TW SI    
Sbjct: 7   VHCIAAIDSEWGIGLKGKLPWNLPREYKFFQNITTKVISEGKQNAVIMGKNTWFSIPQQH 66

Query: 52  RPLPGRKNIILSSQ---PGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQ 102
           RPL  R N+ILSS          V    S++ AI    D      V  I VIGG RVY++
Sbjct: 67  RPLKNRLNVILSSSFIKEDYPKNVLLESSLEAAILRLSDEFYANTVENIFVIGGSRVYKE 126

Query: 103 FLP-KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDAD--AQNSHSYCFEIL 156
            +     K+YLT I+ +   D  +P ++ + ++ +  E  D +   +N  SY F + 
Sbjct: 127 AMEKFCDKIYLTKIEQDYSCDVFYPIFDTNKFKEIDDEEVDKNKQIENGVSYTFHVY 183


>UniRef50_UPI00015B4DEB PREDICTED: similar to conserved hypothetical protein n=1
           Tax=Nasonia vitripennis RepID=UPI00015B4DEB
          Length = 184

 Score =  165 bits (418), Expect = 6e-40,   Method: Composition-based stats.
 Identities = 52/179 (29%), Positives = 85/179 (47%), Gaps = 22/179 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT-------LNKPVIMGRHTWESIG--- 51
           + LIAA   +  IG+   +PW L  ++ +F + T           V+MGR TWESI    
Sbjct: 5   LKLIAAACENMGIGVNGDLPWRLRKEMDFFTKMTSTTKDENKKNVVLMGRRTWESIPKKF 64

Query: 52  RPLPGRKNIILSSQP-GTDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFL 104
           +PL  R N++L+SQP    +     K++ EAI           V ++ VIGG  VY+  +
Sbjct: 65  KPLSNRINMVLTSQPLDLGEDAIVCKNLPEAIEKISQSPLKDKVEQVWVIGGSLVYKTSM 124

Query: 105 --PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVF--SEFHDADAQNSHSYCFEILERR 159
             P   +LYLT +  + + D  FP+  P+D+  V           +    + +E+ E++
Sbjct: 125 ESPNFYRLYLTRVKKDFKCDAFFPEI-PNDYILVKDPEVPEGIQEEKDIKFEYEVYEKK 182


>UniRef50_C3PEY4 Dihydrofolate reductase n=9 Tax=Corynebacterium RepID=C3PEY4_CORA7
          Length = 181

 Score =  164 bits (416), Expect = 9e-40,   Method: Composition-based stats.
 Identities = 53/180 (29%), Positives = 78/180 (43%), Gaps = 23/180 (12%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI---GRPLPGR 57
           M+  I A ++D VIG    MPW++P DL  FK  T+  PVIMGR TWES+    RPLPGR
Sbjct: 1   MLGAIWAQSLDGVIGDGVVMPWHVPEDLKHFKEVTMGAPVIMGRKTWESLTPKFRPLPGR 60

Query: 58  KNIILSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT-- 113
            NI+LS +         T V ++D A+     + +  +IGGG++Y   L +   + LT  
Sbjct: 61  DNIVLSRREPGEWSAGATVVDNLDAAL--HATLDDAWIIGGGQLYSSALDRVDTIELTLM 118

Query: 114 --HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQN------------SHSYCFEILERR 159
              +      D       P+++                             Y F   +R+
Sbjct: 119 GVQVGDAYGADAVLAPSVPEEFSLSADSDWLTSESGHLTIPGQPPSELPMKYRFLTYDRK 178


>UniRef50_C4QMV9 Dihydrofolate reductase n=1 Tax=Schistosoma mansoni
           RepID=C4QMV9_SCHMA
          Length = 186

 Score =  164 bits (415), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 53/177 (29%), Positives = 88/177 (49%), Gaps = 21/177 (11%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL------NKPVIMGRHTWESIG---R 52
           ++++ A++ +  IG    +PW +  D+ +FK  T          V+MGR TWESI    +
Sbjct: 3   LNVVVAVSENWGIGKGGGLPWKIKKDMEFFKTVTTKAHPGLKNAVVMGRVTWESIPESFK 62

Query: 53  PLPGRKNIILSSQPGTDDR-VTWVKSVDEAIAACGDVP------EIMVIGGGRVYEQFLP 105
           PL  R NI++SS        V  V S++ AI    +        E+ +IGG R+Y++ L 
Sbjct: 63  PLKDRINIVVSSTLSHAPSFVQVVPSLNAAIDLLYNEEFSSIVDEVFIIGGYRLYKEALK 122

Query: 106 ---KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDAD--AQNSHSYCFEILE 157
                 ++Y THI +EV+ DT+FP  + D  + V      AD   +N  ++ F + +
Sbjct: 123 QSIYPVRIYCTHILSEVDCDTYFPKVDWDKLKKVDLPDIPADTFTENGFTFKFCVYD 179


>UniRef50_B9YFM0 Dihydrofolate reductase region n=3 Tax=Nostocaceae
           RepID=B9YFM0_ANAAZ
          Length = 166

 Score =  164 bits (415), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 54/167 (32%), Positives = 90/167 (53%), Gaps = 13/167 (7%)

Query: 1   MISLIAALAVDRVIGMENA------MPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPL 54
           +ISLIAA++ +R++           +PW++P+DL  F++ T   PVI+GR ++ +   PL
Sbjct: 3   LISLIAAISENRILADSKKEHIRVGIPWDIPSDLQHFQKKTWRHPVILGRKSYAAFNHPL 62

Query: 55  PGRKNIILSSQPGT-DDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLY 111
           P R NIIL+              S+ EA+  A   +  EI + GGG ++ + +  A KLY
Sbjct: 63  PNRTNIILTRSHDYKAPGCLVFYSLSEAVTWAKMSEKEEIFIAGGGEIFAEAIKFANKLY 122

Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           LT ++   EGD +FP++   ++ +V  E H    +N   + F  +ER
Sbjct: 123 LTIVEGNFEGDVYFPEF--TNFGTVTKEEH--SQENDFQFKFVEIER 165


>UniRef50_C0VZ67 Possible dihydrofolate reductase n=3 Tax=Actinomycetaceae
           RepID=C0VZ67_9ACTO
          Length = 170

 Score =  163 bits (414), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 52/169 (30%), Positives = 90/169 (53%), Gaps = 11/169 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR--PLPGRK 58
           ++ +I A   +  +G  + M W++PAD   FK++T+  P+IMGR +W+++GR  PLP R+
Sbjct: 3   VVKMIWAQDAEGKLGSGSEMLWHVPADFRHFKQSTVGFPLIMGRKSWDALGRFAPLPQRR 62

Query: 59  NIILSSQPGT-DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHID 116
           NI+++       +      S++EAI+      E + + GG  +YEQ +P A +L +T++D
Sbjct: 63  NIVVTRNRDFIPEGGEVAFSIEEAISLASADSELVWIAGGAHIYEQAMPFADELVVTYLD 122

Query: 117 AEVEGD---THFPDYEPDDWESVFSEFHDADAQN---SHSYCFEILERR 159
             V       + P  +P  WE V +E  DAD +       +   +  RR
Sbjct: 123 LNVSTAGPVVYAPQIDPAVWEVVKAE-SDADWREKSGDARWKVVVYRRR 170


>UniRef50_A9HP20 Dihydrofolate reductase n=1 Tax=Roseobacter litoralis Och 149
           RepID=A9HP20_9RHOB
          Length = 154

 Score =  163 bits (413), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 49/134 (36%), Positives = 78/134 (58%), Gaps = 6/134 (4%)

Query: 7   ALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIILSSQ 65
           A A +  IG +  +PWN+P DL +F+R TL   +IMGR+TWES+  +PLP R N+++SS 
Sbjct: 2   ARAENGAIGRDGTIPWNVPEDLKFFQRETLGGALIMGRNTWESLPVKPLPRRFNVVVSSN 61

Query: 66  PGTDDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV-EGD 122
             T +      SV  AI          I  IGG  +Y++ LP A +L ++ +  +V + D
Sbjct: 62  SDTAE--VVAPSVKVAIELAIEHGHQRIYGIGGAAIYQEMLPLAHRLLISEVQIDVPDAD 119

Query: 123 THFPDYEPDDWESV 136
           T FP+++   W+++
Sbjct: 120 TFFPNFDVAGWKAI 133


>UniRef50_Q93341 Putative dihydrofolate reductase n=2 Tax=Caenorhabditis
           RepID=DYR_CAEEL
          Length = 189

 Score =  162 bits (412), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 51/181 (28%), Positives = 76/181 (41%), Gaps = 25/181 (13%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51
           ++LI A+  +  IG    +PW +  D+ +F   T N         V+MGR  WESI    
Sbjct: 4   MNLIVAMDAEGGIGKNGVLPWRIKKDMQYFASVTKNVSDQSKRNAVLMGRKCWESIPVTR 63

Query: 52  RPLPGRKNIILSSQ--PGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQF 103
           RPL GR NI+LS Q      D    V S++ A+    +      +  I  IGG  +Y+  
Sbjct: 64  RPLAGRLNIVLSRQLPAQKSDDYIVVNSLEAAMKLLSEPPFVDSIETIWNIGGAEIYDLA 123

Query: 104 L--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWE-----SVFSEFHDADAQNSHSYCFEIL 156
           L      +++LT I    E D H    +    E      V SE  +   +N   + F   
Sbjct: 124 LRENLVDEIHLTRIFKNFEADVHLKSLDFSKMEKVQNAEVSSENSEIFEENGLKFEFCKW 183

Query: 157 E 157
           +
Sbjct: 184 K 184


>UniRef50_C7REN4 Dihydrofolate reductase region n=2 Tax=Anaerococcus
           RepID=C7REN4_ANAPD
          Length = 164

 Score =  162 bits (411), Expect = 4e-39,   Method: Composition-based stats.
 Identities = 45/161 (27%), Positives = 76/161 (47%), Gaps = 5/161 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + +I A+  +  IG +  M +++  DL  FK  TL    IMGR T+ES+G  L  R+NI+
Sbjct: 1   MKIILAVDKNWGIGKDGQMLFHIRRDLKHFKSYTLGNICIMGRKTYESMGGALTHRENIV 60

Query: 62  LSSQPGTDD-RVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           LS                 + ++   +   E+ VIGG ++ E FL    +  +T I  + 
Sbjct: 61  LSRNKDYKAKDAKVFTDYRDVLSYVRERSEEVFVIGGEKIVEIFLEYCDEAIITKIYEKK 120

Query: 120 EGDTHFPDYE-PDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + D+   +++  DDW    SE  D   +N  S+ +    R+
Sbjct: 121 DADSFLHNFDQDDDWSL--SEESDIMEENGVSFRYVRYRRK 159


>UniRef50_D1AYS8 Dihydrofolate reductase region n=1 Tax=Streptobacillus moniliformis
           DSM 12112 RepID=D1AYS8_STRM9
          Length = 156

 Score =  161 bits (409), Expect = 5e-39,   Method: Composition-based stats.
 Identities = 51/161 (31%), Positives = 93/161 (57%), Gaps = 10/161 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI ++ A+  +  IG +N M W+   +L +F++ TLN  ++MG++T+ SIGRPL  R+NI
Sbjct: 1   MIHIVVAVGENNEIGKDNKMLWHNSEELRFFRKLTLNHKIVMGKNTYLSIGRPLDLRENI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S+    ++ +  ++++D+ +    D  E I VIGG  +Y+QFL   +K+YL+ ID + 
Sbjct: 61  VISTTLEENEDIYVLRNIDKILEKYVDSDEIIYVIGGENIYKQFLKYTEKIYLSKIDGKF 120

Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + D +FP    D+        +  +  N +++   I  RR
Sbjct: 121 PDADRYFPSINYDE--------YSTEVVNYNTFKLYIYTRR 153


>UniRef50_Q934V0 Putative dihydrofolate reductase n=1 Tax=Salmonella enterica subsp.
           enterica serovar Typhi RepID=Q934V0_SALTI
          Length = 158

 Score =  161 bits (409), Expect = 5e-39,   Method: Composition-based stats.
 Identities = 49/160 (30%), Positives = 82/160 (51%), Gaps = 6/160 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + +IAA+  +  IG+ N +PW  P DL  FK+ T N  V+MGR T ES+ RPLP R N++
Sbjct: 1   MKMIAAVGRNYEIGIGNELPWRCPTDLKLFKQLTKNATVVMGRKTMESLKRPLPERHNLV 60

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           L+   G      +   +D+ +        + VIGGG++Y  F+P  ++++L+HI  +V G
Sbjct: 61  LTRSRGYIPNGFYPAGIDDVLRL---PDPVWVIGGGQIYSLFMPHVEEIWLSHIGVDVPG 117

Query: 122 -DTHFPD--YEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            D  FP        +  V + +     ++   +   +  R
Sbjct: 118 ADAFFPAPMMRSLGFVPVETAYTQRANEDEPGFLQIVYRR 157


>UniRef50_C2CJZ1 Possible dihydrofolate reductase n=3 Tax=Anaerococcus
           RepID=C2CJZ1_9FIRM
          Length = 162

 Score =  161 bits (409), Expect = 6e-39,   Method: Composition-based stats.
 Identities = 47/160 (29%), Positives = 74/160 (46%), Gaps = 5/160 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + +I A+  +  IG    M +++  DL  FK  T     IMGR T+ES+G  LP R+N+I
Sbjct: 1   MKIILAVDKNWGIGKNGKMLFHIKKDLGHFKELTSGNICIMGRKTYESMGGALPNRENLI 60

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           LS                 +  +   D   E+ VIGG ++ E FL    +  +T I AE 
Sbjct: 61  LSRNKTYQAPDALVFNDYRDIFSYLEDKDKEVFVIGGEKIVELFLDFCDEAIITKIYAER 120

Query: 120 EGDTHFPDYEPDD-WESVFSEFHDADAQNSHSYCFEILER 158
             D+   +++ DD WE +     D   +N  S+ + +  R
Sbjct: 121 LADSFLHNFDSDDRWEVISK--SDIMEENGVSFQYIVYRR 158


>UniRef50_UPI000006EBF1 PREDICTED: hypothetical protein XP_002346735 n=1 Tax=Homo sapiens
           RepID=UPI000006EBF1
          Length = 262

 Score =  161 bits (408), Expect = 8e-39,   Method: Composition-based stats.
 Identities = 48/181 (26%), Positives = 84/181 (46%), Gaps = 24/181 (13%)

Query: 2   ISLIAALAVDRVIGMENAMPWN-LPADLAWFKRNTL-------NKPVIMGRHTWESIG-- 51
           ++ I A++ +  IG    +PW  L  +  +F+R T           VIMG+ TW SI   
Sbjct: 80  LNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEK 139

Query: 52  -RPLPGRKNIILSSQPGTDDRVTWV--KSVDEAI------AACGDVPEIMVIGGGRVYEQ 102
            RPL GR N++LS +     +      +S+D+A+           V  + ++GG  VY++
Sbjct: 140 NRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKE 199

Query: 103 FLPKAQ--KLYLTHIDAEVEGDTHFPDYEPDDWESVFS---EFHDADAQNSHSYCFEILE 157
            +      KL++T I  + E DT FP+ + + ++ +        D   +    Y FE+ E
Sbjct: 200 AMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYE 259

Query: 158 R 158
           +
Sbjct: 260 K 260


>UniRef50_D2SDU7 Dihydrofolate reductase n=1 Tax=Geodermatophilus obscurus DSM 43160
           RepID=D2SDU7_9ACTO
          Length = 176

 Score =  160 bits (407), Expect = 9e-39,   Method: Composition-based stats.
 Identities = 57/143 (39%), Positives = 81/143 (56%), Gaps = 6/143 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           + L+ A A   VIG +  +PW+LP DL  F+  T    V+MGR TWES+    RPLPGR+
Sbjct: 3   VGLVWAQARGGVIGADGRLPWHLPEDLRLFRELTTGSTVVMGRRTWESLPERFRPLPGRR 62

Query: 59  NIILSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           N++L++      D    V  V++ +A   D  ++ VIGGGRVY  FLP A ++ +T +D 
Sbjct: 63  NVVLTTDRSWAADGAERVDGVEDVLARTDDG-DLWVIGGGRVYAAFLPHADRVVVTDVDT 121

Query: 118 EVEGDTHFPDYEPDDWESVFSEF 140
           +VEGDT  P     +W  V    
Sbjct: 122 DVEGDTWAPQLGA-EWARVSRTP 143


>UniRef50_Q4JX60 FolA protein n=3 Tax=Corynebacterium RepID=Q4JX60_CORJK
          Length = 234

 Score =  160 bits (407), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 58/195 (29%), Positives = 84/195 (43%), Gaps = 39/195 (20%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           I +I A   D VIG    MPW LP DL  FK  T   PV+MGR +WE++    RPLP R 
Sbjct: 42  IGMIWAQTTDGVIGDGADMPWYLPEDLKHFKNATSGYPVVMGRTSWEALDDGFRPLPDRT 101

Query: 59  NIILSSQPGTDDRVTWVK-SVDEAIAACGD-------------------VPEIMVIGGGR 98
           N +++ Q   D     V+ S+  A+A   +                    P + V+GGG+
Sbjct: 102 NYVITRQDNYDAPGGIVEPSIPSALANAAEQILNELTDSADKGEGADDRTPTVWVLGGGQ 161

Query: 99  VYEQFLPKAQKLYLTHIDAE----VEGDTHFPDYEPDDWES------VFSEFHDADA--- 145
           VY Q +P A ++ +T ID E     +   + P    +++E          + H  D    
Sbjct: 162 VYAQCMPVADRIVITEIDMEAPERFQ--VYAPLVPEEEFEESAQDWQESEKGHPVDQEVD 219

Query: 146 -QNSHSYCFEILERR 159
            +    Y F    RR
Sbjct: 220 TEQPLRYRFCTWTRR 234


>UniRef50_P15093 Dihydrofolate reductase n=3 Tax=Halobacteriaceae RepID=DYR_HALVO
          Length = 162

 Score =  159 bits (404), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 52/159 (32%), Positives = 84/159 (52%), Gaps = 12/159 (7%)

Query: 5   IAALAVDRVIGMENAMPW-NLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +AALA +RVIG +  +PW ++PAD   ++    + PV++GR T+ES+   LPG   I++S
Sbjct: 6   VAALAENRVIGRDGELPWPSIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65

Query: 64  S--QPGTDDRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
              +  + D      SV+EA  IAA  D     VIGG  +Y  F P   ++ L+ +  E 
Sbjct: 66  RSERSFSVDTAHRAASVEEAVDIAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEY 125

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGDT++P+++  +WE      H+        +  +   R
Sbjct: 126 EGDTYYPEWDAAEWELDAETDHEG-------FTLQEWVR 157


>UniRef50_A3DES9 Dihydrofolate reductase n=5 Tax=Clostridium RepID=A3DES9_CLOTH
          Length = 167

 Score =  159 bits (403), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 48/156 (30%), Positives = 76/156 (48%), Gaps = 8/156 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59
           +  I A+  +  IG +  +   +P D+ +F++ TLNK V+MGR T+ES+    PL  R N
Sbjct: 1   MKAIVAVDSNWGIGYKGNLLQRIPEDMRFFRQMTLNKVVVMGRKTFESLPGKEPLKDRVN 60

Query: 60  IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           IILS     + D +   +SVD         +  +I VIGG  VY Q LP   + ++T  +
Sbjct: 61  IILSKSENIEKDGIIICRSVDGLFLELKKYNSDDIFVIGGEEVYTQLLPYCSEAHVTKFN 120

Query: 117 AEVEGDTHFPDYEP-DDWESVFSEFHDADAQNSHSY 151
                D +FP+ +  + W+ V     +    N   Y
Sbjct: 121 GAYSADRYFPNLDEMEGWKLVC--VGEPKEFNDIRY 154


>UniRef50_P11731 Dihydrofolate reductase type 5 n=27 Tax=Bacteria RepID=DYR5_ECOLX
          Length = 157

 Score =  158 bits (402), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 54/160 (33%), Positives = 94/160 (58%), Gaps = 9/160 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SL+AA A + VIG    +PW+   +   FK  T N+ +++GR T+ES+G  LP RK  +
Sbjct: 3   VSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAV 61

Query: 62  LSSQPGT--DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++    T  +D V    S++EA+    ++ + ++V GGG +Y + LP A  L+++ ID E
Sbjct: 62  VTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIE 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            EGD  FP+  P+ +E VF +   ++     +YC++I ++
Sbjct: 122 PEGDVFFPNI-PNTFEVVFEQHFSSN----INYCYQIWQK 156


>UniRef50_C4V3M4 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase protein n=1
           Tax=Selenomonas flueggei ATCC 43531 RepID=C4V3M4_9FIRM
          Length = 322

 Score =  158 bits (402), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 47/164 (28%), Positives = 66/164 (40%), Gaps = 16/164 (9%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59
           + LIAA+     IG    +  + P D+A F+R T+   V+MGR T ES+   RPL GR N
Sbjct: 167 LELIAAVDDAGGIGRAGHLLTDCPEDMAHFRRMTMGGIVVMGRRTMESLPGRRPLVGRMN 226

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAA-----CGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           I+LS      D       +             +   I VIGG   Y   LP   + Y+T 
Sbjct: 227 IVLSRTMQETDGFYAAADILALWRLLGRLTAEEARPIFVIGGAACYRLLLPYVWRAYVTR 286

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +    + D  FP  +   +    S              FE+ ER
Sbjct: 287 LLGSYDADVFFPSLD--GFSMTSSSAGQ-------DCIFEVYER 321


>UniRef50_Q86ZU9 Dihydrofolate reductase n=2 Tax=Agaricales RepID=Q86ZU9_COPCI
          Length = 205

 Score =  158 bits (402), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 48/200 (24%), Positives = 76/200 (38%), Gaps = 43/200 (21%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT------LNKPVIMGRHTWESIG---R 52
           +++I A      IG  + +PW L  ++ +F R T          V+MGR TWESI    R
Sbjct: 4   LTIIVAATKANGIGKGSNLPWRLAKEMKYFARATSEAPEGTRNAVVMGRTTWESIPEKFR 63

Query: 53  PLPGRKNIILSSQPGTD--------DRVTWVKSVDEAIAACGDVP-----EIMVIGGGRV 99
           PLP R N+++S     +               S+   +             I VIGG  +
Sbjct: 64  PLPNRVNVVVSRNENYELEPGKEPSPMARLANSLSSGLRHLTTTDGLTVNRIFVIGGASL 123

Query: 100 YEQFL--------PKAQKLYLTHI-DAEVEGDTHFPDYEPD--DWESV----------FS 138
           Y + L        P   ++ LT I + + + D   P++  D  +W             FS
Sbjct: 124 YRETLSLARSKTGPFVDRILLTRIVEPDFDCDVFMPEFNADGKEWTRSTHAELQEWVGFS 183

Query: 139 EFHDADAQNSHSYCFEILER 158
                  +N   Y F++  R
Sbjct: 184 VPEGIQEENGVKYEFQMWTR 203


>UniRef50_A8RBH0 Putative uncharacterized protein n=1 Tax=Eubacterium dolichum DSM
           3991 RepID=A8RBH0_9FIRM
          Length = 153

 Score =  158 bits (401), Expect = 5e-38,   Method: Composition-based stats.
 Identities = 36/136 (26%), Positives = 66/136 (48%), Gaps = 4/136 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI++I A+  + +IG +N +PW+ P DL  F R   N  ++MG+ T++SI   L      
Sbjct: 1   MIAMIVAVDKNGLIGNKNRLPWHCPEDLKHFYRTIKNHELLMGKRTFDSIR--LKDNVVH 58

Query: 61  ILSSQP-GTDDRVTWVKSVDEAI-AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +++ Q     D +     +   +         + V GG  +Y+Q  P   + Y++ ID E
Sbjct: 59  VVTHQTIKEQDNIRICTDLSAFLKQWQTSEKTLFVCGGASIYQQAFPFCSEAYVSVIDGE 118

Query: 119 VEGDTHFPDYEPDDWE 134
            +GD + P  +   ++
Sbjct: 119 YQGDCYLPPMDFSLFQ 134


>UniRef50_B1V8Y8 Dihydrofolate reductase n=6 Tax=Candidatus Phytoplasma
           RepID=B1V8Y8_PHYAS
          Length = 165

 Score =  158 bits (401), Expect = 6e-38,   Method: Composition-based stats.
 Identities = 46/167 (27%), Positives = 78/167 (46%), Gaps = 15/167 (8%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-----RPLP 55
           MI+LI A   + +IG +N +PW+ P DL +FK+ TLN+ V+MG  T+ S+      +P  
Sbjct: 1   MINLITAFDSNYLIGSDNKLPWHYPQDLHFFKKTTLNQEVLMGHQTYLSLKSYFKDKPFN 60

Query: 56  GRKNIILSSQPGTD-DRVTWVKSVDEAIA--ACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112
            +K  + +   G   D    V  +   +          + VIGG ++Y+Q LP    LY+
Sbjct: 61  FKKTYVAARNKGLQLDGCEVVFDLLTFLKTFLIQKKSHLFVIGGRQIYQQSLPFVDNLYI 120

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T+I    +G+ +FP     D++ +                F   +R+
Sbjct: 121 TYILNRHKGNVYFPPVNWQDFQLIQKTIQPQ-------LIFAFYKRK 160


>UniRef50_A4GI75 Dihydrofolate reductase n=1 Tax=uncultured marine bacterium
           HF10_29C11 RepID=A4GI75_9BACT
          Length = 168

 Score =  158 bits (400), Expect = 6e-38,   Method: Composition-based stats.
 Identities = 51/167 (30%), Positives = 79/167 (47%), Gaps = 10/167 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNK---PVIMGRHTWESIG---RPL 54
           M+ +I A+ +D  IG EN +PW L +D+  FKR T+ +    V+MGR TWE+I    RPL
Sbjct: 2   MLKMILAMDLDGCIGKENGLPWRLQSDMLRFKRLTIGQGNSAVLMGRTTWETIPERFRPL 61

Query: 55  PGRKNIILSSQPGTD-DRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLY 111
             R NI+++              S++  I      +  E  +IGG  VYEQ      +++
Sbjct: 62  VDRINIVVTRNRNYALSDAHVTYSIENGIEHASNNNCDECWIIGGADVYEQCRDLVDEIH 121

Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           LT ++    GD     +  D+W     E     + N H   + IL +
Sbjct: 122 LTSVETSNSGDIKVGMFG-DEWNREIIESTPESSDNEHPTTYMILRK 167


>UniRef50_C5IWK1 Dihydrofolate reductase n=15 Tax=Bacteria RepID=C5IWK1_ECOLX
          Length = 157

 Score =  158 bits (400), Expect = 6e-38,   Method: Composition-based stats.
 Identities = 42/160 (26%), Positives = 84/160 (52%), Gaps = 9/160 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS++AA++ + VIG    +PW++  +   FK  T N  +++GR T++S+G+ LP RK  +
Sbjct: 3   ISIMAAVSENGVIGSGLDIPWHVQGEQLLFKAMTYNHWLLVGRKTFDSMGK-LPNRKYAV 61

Query: 62  LSSQP--GTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D  V +  S++ A++   +    + V GGG +Y+  + +A  ++L+ I   
Sbjct: 62  VTRSEMVSNDPDVIYFTSIESALSYLDNTTTHVFVSGGGEIYKALIEQADVIHLSVIHKH 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + GD  FP   P  ++  F +   ++      Y ++I  +
Sbjct: 122 ISGDVFFPSV-PQSFKQTFEQSFSSN----IDYTYQIWAK 156


>UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraurelia
           RepID=DRTS_PARTE
          Length = 462

 Score =  157 bits (399), Expect = 8e-38,   Method: Composition-based stats.
 Identities = 44/159 (27%), Positives = 83/159 (52%), Gaps = 6/159 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
            S++ A+ ++  IG +N +PW L  DL  FK+ T    VIMGR T+ES+  +PLP R N+
Sbjct: 7   FSMVLAMTLNGGIGYQNRLPWKLKEDLQRFKKITTGGIVIMGRKTFESMNSKPLPNRVNV 66

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACG-DVPEIMVIGGGRVYEQFL--PKAQKLYLTHIDA 117
           ++S    + + V     +++A+        ++ +IGG R++E+ L   K   ++LT I  
Sbjct: 67  VISKNMKSSNEVQVFPRIEDALQFYNTSHQKLYLIGGKRIFEEGLATDKCSDVHLTRIGV 126

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
           E + D +        ++   ++     ++N  +Y ++ L
Sbjct: 127 ETKCDVYLNKNIFSTFQV--NKTSQTKSENGINYDYQHL 163


>UniRef50_P78218 Dihydrofolate reductase type 15 n=153 Tax=root RepID=DYR15_ECOLX
          Length = 157

 Score =  157 bits (399), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 51/160 (31%), Positives = 92/160 (57%), Gaps = 9/160 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SL+AA++ + VIG    +PW+   +   FK  T N+ +++GR T+ES+G  LP RK  +
Sbjct: 3   LSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMG-ALPNRKYAV 61

Query: 62  LSSQPGT--DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++    T  D+ V    S+DEA+     + + ++V GGG +Y+  + K   L+++ ID E
Sbjct: 62  VTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDIE 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            EGD +FP+  P  +  VFS+   ++     +Y ++I ++
Sbjct: 122 PEGDVYFPEI-PSSFRPVFSQDFVSN----INYSYQIWQK 156


>UniRef50_C5RC79 Dihydrofolate reductase n=1 Tax=Weissella paramesenteroides ATCC
           33313 RepID=C5RC79_WEIPA
          Length = 168

 Score =  157 bits (398), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 51/161 (31%), Positives = 84/161 (52%), Gaps = 4/161 (2%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNII 61
           +LI A  +D  I ++  +PW+  ADL +FK++T+++  +MGRHT  S  GRPLP R N++
Sbjct: 8   NLIWAQTLDGTIAIDGHIPWHQKADLQFFKQSTIHEAALMGRHTMASFHGRPLPERLNLV 67

Query: 62  LSSQPGTD--DRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           L+     +  +    V SV EA     +   ++ VIGG  +YE F+  A  LY+T++  +
Sbjct: 68  LTRNHDLEVPEGFQKVYSVAEAEKVADNANLKLQVIGGKPIYESFMDTADTLYVTYLQTD 127

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
             GD      +   W+    +   ADA N + +      R+
Sbjct: 128 FSGDVKMAPVDLTVWQGEVIDQGPADADNDYDWRLVKYTRQ 168


>UniRef50_B2GI60 Dihydrofolate reductase n=3 Tax=Actinomycetales RepID=B2GI60_KOCRD
          Length = 183

 Score =  157 bits (398), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 59/181 (32%), Positives = 87/181 (48%), Gaps = 25/181 (13%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           M+  I A + D VIG++  +PW+L  DL +F R T+  PVIMGR TWES     RPLPGR
Sbjct: 1   MVGAIWAQSPDGVIGVDGGIPWHLSEDLKFFARTTIGHPVIMGRRTWESFPEQFRPLPGR 60

Query: 58  KNIILSSQPGT----DDRVTWVKSVDEAIAAC------------GDVPEIMVIGGGRVYE 101
            NI+++S+P +     +RV  V S  EA+                   E+ VIGG  V+ 
Sbjct: 61  PNIVITSRPESVPADGERVWAVGSYAEALELAVSLLAAPGPEHEEPAREVWVIGGPGVWR 120

Query: 102 QFLPK----AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
           + +        +  +T +D +V GDTH P  +   W          +A+N   +  +   
Sbjct: 121 EAVSHRPLPLTRALVTTVDLDVTGDTHAPALDGS-WSR-REVAGWTEARNGTWFRIDEWT 178

Query: 158 R 158
           R
Sbjct: 179 R 179


>UniRef50_P00374 Dihydrofolate reductase n=50 Tax=root RepID=DYR_HUMAN
          Length = 187

 Score =  157 bits (397), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 48/181 (26%), Positives = 84/181 (46%), Gaps = 24/181 (13%)

Query: 2   ISLIAALAVDRVIGMENAMPWN-LPADLAWFKRNTL-------NKPVIMGRHTWESIG-- 51
           ++ I A++ +  IG    +PW  L  +  +F+R T           VIMG+ TW SI   
Sbjct: 5   LNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEK 64

Query: 52  -RPLPGRKNIILSSQPGTDDRVTWV--KSVDEAI------AACGDVPEIMVIGGGRVYEQ 102
            RPL GR N++LS +     +      +S+D+A+           V  + ++GG  VY++
Sbjct: 65  NRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKE 124

Query: 103 FLPKAQ--KLYLTHIDAEVEGDTHFPDYEPDDWESVFS---EFHDADAQNSHSYCFEILE 157
            +      KL++T I  + E DT FP+ + + ++ +        D   +    Y FE+ E
Sbjct: 125 AMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYE 184

Query: 158 R 158
           +
Sbjct: 185 K 185


>UniRef50_B7VPW7 Dihydrofolate reductase type I (Trimethoprim resistance) n=2
           Tax=Vibrio splendidus RepID=B7VPW7_VIBSL
          Length = 183

 Score =  157 bits (397), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 50/160 (31%), Positives = 89/160 (55%), Gaps = 9/160 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SL+AA+A + VIG    +PW +  +   FK  T N+ +++GR T+ES+G+ LP RK  +
Sbjct: 29  LSLMAAVAENGVIGSGLDIPWIVKGEQLLFKAMTFNQWLLLGRKTFESMGK-LPNRKYAV 87

Query: 62  LSSQPGT--DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +S  P T  D  + + KSV++A+     V E   V GGG++Y+  + +   ++++ I   
Sbjct: 88  ISRSPSTSNDPDILYFKSVEDALGYLETVTEHAFVSGGGQIYKSLITQVDTIHISKIHKH 147

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + GD  FP+  P D   VF +   ++      Y ++I ++
Sbjct: 148 ISGDIFFPEL-PRDLTLVFEQRFSSN----IDYTYQIWQK 182


>UniRef50_P00381 Dihydrofolate reductase n=9 Tax=Lactobacillus RepID=DYR_LACCA
          Length = 163

 Score =  156 bits (396), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 45/163 (27%), Positives = 81/163 (49%), Gaps = 5/163 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           M + + A   D +IG +  +PW+LP DL +F+  T+ K +++GR T+ES   RPLP R N
Sbjct: 1   MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN 60

Query: 60  IILSSQPGTDDRV---TWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++L+ Q     +        +   A A      E+++ GG +++  F      L +T + 
Sbjct: 61  VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
              EGDT       DD+  V S   + D   + ++ +E+ +++
Sbjct: 121 GSFEGDTKMIPLNWDDFTKVSSRTVE-DTNPALTHTYEVWQKK 162


>UniRef50_Q6CC38 YALI0C12771p n=1 Tax=Yarrowia lipolytica RepID=Q6CC38_YARLI
          Length = 189

 Score =  156 bits (395), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 58/182 (31%), Positives = 87/182 (47%), Gaps = 27/182 (14%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTL---NKPVIMGRHTWESIG---RPLPGR 57
           ++AA      IG+   +PW L  ++ +FK+ T    N  VIMGR TW+SI    RPLP R
Sbjct: 8   ILAATVPRYGIGLNGGLPWRLAKEMKFFKQVTTAQKNAVVIMGRTTWDSIPPKFRPLPDR 67

Query: 58  KNIILSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL--PKAQKLYLT 113
            NI+L+S+P TD  + V   +S DEA+  C +   + VIGG +VY+  L     + + LT
Sbjct: 68  TNIVLTSRPMTDAPEEVVVARSFDEALTKCPEDSTVYVIGGSQVYKTALVHEHTKAVLLT 127

Query: 114 HI---DAEVEGDTHFPDYEPDDWESVFSEFHD--------------ADAQNSHSYCFEIL 156
            I   D  VE DT F  ++   W+    E                    +   S+ + + 
Sbjct: 128 EITCPDGHVECDTFFEGFDQGLWKKQPYERLQDFVGDKVELPGRDTPVEEKGFSFVYTLW 187

Query: 157 ER 158
           E+
Sbjct: 188 EK 189


>UniRef50_A6DQ18 Dihydrofolate reductase region n=1 Tax=Lentisphaera araneosa
           HTCC2155 RepID=A6DQ18_9BACT
          Length = 149

 Score =  156 bits (395), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 47/159 (29%), Positives = 81/159 (50%), Gaps = 11/159 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M+SLI+A+  + +IG   A+PW +  +   +      K +I+GR T+E  G  L   +  
Sbjct: 1   MLSLISAMDKNGLIGTGKALPWKVEEEYQRYLDTVKGKKIIVGRKTFEISGLDLKDEQVH 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ILSS+        +  ++++AI ACG+  +I V GG  VY+  +P A +LY++ I  + E
Sbjct: 61  ILSSRSQ---GTNYYNNIEDAIKACGE-NDIFVTGGAEVYKLAMPHADRLYISVIKGDYE 116

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           G  +FP+ + + WE    E           Y + I  ++
Sbjct: 117 GSIYFPNIDANIWEVQHHEELPE-------YDYYIYRKK 148


>UniRef50_UPI00017450E9 dihydrofolate reductase type III n=1 Tax=Verrucomicrobium spinosum
           DSM 4136 RepID=UPI00017450E9
          Length = 179

 Score =  155 bits (394), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 50/162 (30%), Positives = 82/162 (50%), Gaps = 7/162 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60
           ++LIAA+  + ++     +PW LP D+A F+     K +++GRHT+E + G   P +  +
Sbjct: 8   LTLIAAVDENLLLATAQGIPWKLPDDVAHFRAYCAGKWLLLGRHTYEDMTGWFKPDQHPL 67

Query: 61  ILSSQPGTDDR-VTWVKSVDEAIAA--CGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +L+S  G +      V SV +A+A        E++ IGGG+V+   LP A +L +THI  
Sbjct: 68  VLTSTCGYEPNPGRGVASVPQALALAEAEGQEELVCIGGGQVFATALPHATRLVITHIKH 127

Query: 118 EVE-GD--THFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
             E GD   +FP    D W       H  D +++  + F   
Sbjct: 128 IFEPGDQPVYFPPISADAWREERRLDHAVDDRHAWPFTFVEY 169


>UniRef50_P16184 Dihydrofolate reductase n=38 Tax=Pneumocystis RepID=DYR_PNECA
          Length = 206

 Score =  154 bits (391), Expect = 7e-37,   Method: Composition-based stats.
 Identities = 55/198 (27%), Positives = 88/198 (44%), Gaps = 41/198 (20%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT----------LNKPVIMGRHTWESIG 51
           ++LI AL     IG  N++PW L  ++++FKR T              V+MGR TWESI 
Sbjct: 7   LTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIP 66

Query: 52  ---RPLPGRKNIILSSQPGTD--DRVTWVKSVDEAIAAC---------GDVPEIMVIGGG 97
              RPL GR N++++     D  + +   KS+D A+              +  I VIGG 
Sbjct: 67  LQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGA 126

Query: 98  RVYEQFL--PKAQKLYLTHIDAEVEGDTHFP-DYEPDDWESVFSEF-------------- 140
           ++Y+  +  PK  ++  T I  ++  D  FP  +   +W SV+ +               
Sbjct: 127 QLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVP 186

Query: 141 HDADAQNSHSYCFEILER 158
           H    ++   Y FE+  R
Sbjct: 187 HGKINEDGFDYEFEMWTR 204


>UniRef50_Q59397 Dihydrofolate reductase type 9 n=1 Tax=Escherichia coli
           RepID=DYR9_ECOLX
          Length = 177

 Score =  154 bits (391), Expect = 8e-37,   Method: Composition-based stats.
 Identities = 49/164 (29%), Positives = 75/164 (45%), Gaps = 11/164 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +++I A+     IG EN +PW+ P DL  FK  T+N  +IMGR T+ S+ + LPGR +++
Sbjct: 4   LNMIVAVNKTGGIGFENQIPWHEPEDLKHFKAVTMNSVLIMGRKTFASLPKVLPGRLHVV 63

Query: 62  LSSQ---PGTDDRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYL 112
           +S         D+V +V +   A+          +  +I VIGG   YE       KLYL
Sbjct: 64  VSKTVPPTQNTDQVVYVSTYQIAVRTASLLVDKPEYSQIFVIGGKSAYENLAAYVDKLYL 123

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
           T +    + DT         W+ V         +N     F+I 
Sbjct: 124 TRVQLNTQQDTELDLSLFKSWKLVSEV--PTITENKTKLIFQIW 165


>UniRef50_D2NRG7 Dihydrofolate reductase n=2 Tax=Rothia mucilaginosa
           RepID=D2NRG7_9MICC
          Length = 222

 Score =  153 bits (388), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 63/216 (29%), Positives = 82/216 (37%), Gaps = 59/216 (27%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           +  I A     +IG    MPW  P DLA FK+ TL  PVIMGR TWES     RPLPGR 
Sbjct: 5   LGAIWAQTDAGIIGRAGDMPWYAPEDLAHFKKVTLGAPVIMGRRTWESFPPRFRPLPGRT 64

Query: 59  NIILSSQ---PGTDDRVTWVKSVDEAIAACGD------------------VPEIMVIGGG 97
           NI++S         D   WV S+D A+ A  D                    +  +IGGG
Sbjct: 65  NIVISRSVTEAEERDGALWVPSLDAALYAARDAVGAPVEATPADTATDAPAVDAWIIGGG 124

Query: 98  RVYEQFLPKAQ------------KLYLTHIDAEVEGDTHFPDYEPDD------------- 132
            VY + L +               L+      E+ GDT  P+ +  D             
Sbjct: 125 SVYAEALSRNDLPAFGRVKTVERTLFYCQEGNEITGDTRAPELQLADSHGNCATGSPNGC 184

Query: 133 WESVFSEFHDADA----------QNSHSYCFEILER 158
           W  V     +             +N   + F+ LER
Sbjct: 185 WHVVSETAWEKSEKGYLLDESGTKNPMYFSFQRLER 220


>UniRef50_A8SSS6 Putative uncharacterized protein n=2 Tax=Bacteria
           RepID=A8SSS6_9FIRM
          Length = 168

 Score =  153 bits (388), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 44/162 (27%), Positives = 69/162 (42%), Gaps = 8/162 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59
           +  IAA+  +  IG + ++   +  D   F++ T+   V++GR T E     RPL GR N
Sbjct: 1   MKFIAAVDNNWAIGNKGSLLVRISEDQKNFRKETMGHVVVLGRKTLEEFPGGRPLKGRTN 60

Query: 60  IILSSQPGTDD-RVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHID 116
           IILS+ P         V S+DE      +    +I +IGG  VY+  +P      +T ID
Sbjct: 61  IILSTNPDYTVQDAVVVHSIDELFEKLSEYESDDIFIIGGQTVYDVLIPYCDTGIVTKID 120

Query: 117 AEVEGDTHFPDYEP-DDWESVFSEFHDADAQNSHSYCFEILE 157
              E D    + +  D+W             N  +  F   +
Sbjct: 121 KSYEADAFIQNLDEMDNWHV--ENERSGTEPNDVNITFVTYK 160


>UniRef50_P27422 Dihydrofolate reductase type 7 n=46 Tax=Bacteria RepID=DYR7_ECOLX
          Length = 157

 Score =  153 bits (387), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 48/160 (30%), Positives = 92/160 (57%), Gaps = 9/160 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI+A + + VIG    +PW+   +   FK  T N+ +++GR T++S+G  LP RK  +
Sbjct: 3   ISLISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMG-VLPNRKYAV 61

Query: 62  LSSQ--PGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +S +    +++ V    S++ A+     + + + V GGG++Y   + KA  ++L+ +  E
Sbjct: 62  VSRKGISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHVE 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           VEGD +FP   P+++  VF +F  ++     +Y ++I ++
Sbjct: 122 VEGDINFPKI-PENFNLVFEQFFLSN----INYTYQIWKK 156


>UniRef50_C5VBQ6 Dihydrofolate reductase n=5 Tax=Corynebacterium RepID=C5VBQ6_9CORY
          Length = 160

 Score =  152 bits (386), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 60/167 (35%), Positives = 85/167 (50%), Gaps = 20/167 (11%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           M+  I A  +  +IG   +MPW++P DL  FK+ TL  P+IMGR TWES+  RPLPGRKN
Sbjct: 1   MLRAIWAQNLMGLIGDGKSMPWHVPEDLQHFKKLTLGSPIIMGRRTWESLPVRPLPGRKN 60

Query: 60  IILSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           ++LS +      +  + + SV E+           VIGGG VY   + K Q+++ T IDA
Sbjct: 61  LVLSRRTPGKWSNGASVIASVPES---------GWVIGGGVVYAATIDKVQEIHRTLIDA 111

Query: 118 E---VE-GD--THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
                E GD     P   PD ++ V        + +   Y FE   +
Sbjct: 112 PTNLFELGDRAVFAPTIPPD-FQLVQHSKWLKSS-SGLRYKFETWTK 156


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_P11045 Dihydrofolate reductase n=23 Tax=Firmicutes RepI...   228   5e-59
UniRef50_A7Z5T2 DfrA n=2 Tax=Bacillaceae RepID=A7Z5T2_BACA2           223   1e-57
UniRef50_Q65IB5 DfrA n=4 Tax=Bacillaceae RepID=Q65IB5_BACLD           219   3e-56
UniRef50_B0MUX5 Putative uncharacterized protein n=1 Tax=Alistip...   218   5e-56
UniRef50_P0ABQ5 Dihydrofolate reductase n=111 Tax=Enterobacteria...   217   1e-55
UniRef50_P12833 Dihydrofolate reductase type 3 n=26 Tax=Proteoba...   217   1e-55
UniRef50_D0U4K0 Dihydrofolate reductase n=2 Tax=uncultured SUP05...   216   2e-55
UniRef50_D2QJY0 Dihydrofolate reductase n=2 Tax=Bacteria RepID=D...   213   2e-54
UniRef50_Q1LK80 Dihydrofolate reductase n=3 Tax=Proteobacteria R...   213   2e-54
UniRef50_P27498 Dihydrofolate reductase n=89 Tax=Gammaproteobact...   212   3e-54
UniRef50_A9I779 FolA protein n=2 Tax=Bordetella RepID=A9I779_BORPD    209   2e-53
UniRef50_A1U3D7 Dihydrofolate reductase n=6 Tax=Gammaproteobacte...   209   2e-53
UniRef50_D0KZ69 Dihydrofolate reductase n=2 Tax=Gammaproteobacte...   208   5e-53
UniRef50_A9KH09 Dihydrofolate reductase n=8 Tax=Coxiella burneti...   208   5e-53
UniRef50_A4Y040 Dihydrofolate reductase n=28 Tax=Proteobacteria ...   208   6e-53
UniRef50_P43791 Dihydrofolate reductase n=19 Tax=Gammaproteobact...   206   1e-52
UniRef50_A5FJX2 Dihydrofolate reductase n=1 Tax=Flavobacterium j...   206   2e-52
UniRef50_A0AJX9 DfrA protein n=15 Tax=Listeria RepID=A0AJX9_LISW6     206   2e-52
UniRef50_C6P459 Dihydrofolate reductase n=1 Tax=Sideroxydans lit...   205   4e-52
UniRef50_Q3JEI1 Dihydrofolate reductase n=3 Tax=Gammaproteobacte...   204   6e-52
UniRef50_C2FZ23 Dihydrofolate reductase n=2 Tax=Sphingobacterium...   204   6e-52
UniRef50_Q31I54 Dihydrofolate reductase n=32 Tax=Bacteria RepID=...   204   1e-51
UniRef50_Q2SXY8 Dihydrofolate reductase n=18 Tax=Proteobacteria ...   203   2e-51
UniRef50_Q2Y7L3 Dihydrofolate reductase n=7 Tax=Betaproteobacter...   203   2e-51
UniRef50_C6X2F4 Dihydrofolate reductase n=20 Tax=Bacteroidetes R...   202   3e-51
UniRef50_UPI0001787F40 Dihydrofolate reductase n=1 Tax=Geobacill...   202   3e-51
UniRef50_Q0VM07 Dihydrofolate reductase n=5 Tax=Gammaproteobacte...   201   6e-51
UniRef50_A2SN57 Dihydrofolate reductase n=34 Tax=Burkholderiales...   201   7e-51
UniRef50_Q1QUE0 Dihydrofolate reductase n=12 Tax=Bacteria RepID=...   201   8e-51
UniRef50_C9RIZ1 Dihydrofolate reductase n=1 Tax=Fibrobacter succ...   200   1e-50
UniRef50_A1AXR7 Dihydrofolate reductase n=6 Tax=Proteobacteria R...   200   1e-50
UniRef50_Q1CZU3 Dihydrofolate reductase n=1 Tax=Myxococcus xanth...   200   2e-50
UniRef50_Q3K556 Dihydrofolate reductase n=8 Tax=Bacteria RepID=Q...   199   2e-50
UniRef50_A5EUV9 Dihydrofolate reductase n=1 Tax=Dichelobacter no...   199   2e-50
UniRef50_Q67JQ2 Dihydrofolate reductase n=1 Tax=Symbiobacterium ...   199   2e-50
UniRef50_C7PKU6 Dihydrofolate reductase n=1 Tax=Chitinophaga pin...   199   3e-50
UniRef50_C0YTZ2 Possible dihydrofolate reductase type I involved...   198   4e-50
UniRef50_C7RLL7 Dihydrofolate reductase n=1 Tax=Candidatus Accum...   198   6e-50
UniRef50_Q15PF1 Dihydrofolate reductase n=18 Tax=Gammaproteobact...   198   7e-50
UniRef50_C9BJS9 Dihydrofolate reductase n=13 Tax=Enterococcus Re...   197   9e-50
UniRef50_Q5WDS2 Dihydrofolate reductase n=3 Tax=Bacillus RepID=Q...   197   9e-50
UniRef50_Q5R038 Dihydrofolate reductase n=3 Tax=Alteromonadales ...   197   9e-50
UniRef50_C1XJD1 Dihydrofolate reductase n=1 Tax=Meiothermus rube...   197   1e-49
UniRef50_Q47IJ5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=Q...   197   1e-49
UniRef50_A5GBA2 Dihydrofolate reductase n=2 Tax=Geobacter RepID=...   197   1e-49
UniRef50_A7HVX5 Dihydrofolate reductase n=13 Tax=Proteobacteria ...   197   1e-49
UniRef50_A1VQZ7 Dihydrofolate reductase n=9 Tax=Bacteria RepID=A...   196   1e-49
UniRef50_D0J2N2 Dihydrofolate reductase region n=3 Tax=Bacteria ...   196   1e-49
UniRef50_UPI0000E87D66 dihydrofolate reductase n=1 Tax=Methyloph...   196   2e-49
UniRef50_A2U3M8 Dihydrofolate reductase n=2 Tax=Polaribacter Rep...   196   2e-49
UniRef50_C6CYL9 Dihydrofolate reductase n=1 Tax=Paenibacillus sp...   196   2e-49
UniRef50_Q04F50 Dihydrofolate reductase n=2 Tax=Oenococcus oeni ...   196   3e-49
UniRef50_Q5X875 Dihydrofolate reductase FolA n=6 Tax=Legionella ...   195   4e-49
UniRef50_A6UB22 Dihydrofolate reductase n=18 Tax=Alphaproteobact...   194   5e-49
UniRef50_D1BNV5 Dihydrofolate reductase region n=4 Tax=Veillonel...   194   6e-49
UniRef50_A4IUE2 Dihydrofolate reductase n=1 Tax=Yersinia ruckeri...   194   6e-49
UniRef50_A5CVJ7 Dihydrofolate reductase n=1 Tax=Candidatus Vesic...   194   9e-49
UniRef50_Q21NW4 Dihydrofolate reductase n=3 Tax=Bacteria RepID=Q...   194   1e-48
UniRef50_C5CTW3 Dihydrofolate reductase n=1 Tax=Variovorax parad...   193   2e-48
UniRef50_UPI0001698640 dihydrofolate reductase n=1 Tax=Endorifti...   193   2e-48
UniRef50_Q11US6 Dihydrofolate reductase n=1 Tax=Cytophaga hutchi...   193   2e-48
UniRef50_D2QWB5 Dihydrofolate reductase n=1 Tax=Pirellula staley...   193   2e-48
UniRef50_Q54277 Dihydrofolate reductase n=84 Tax=Bacilli RepID=D...   193   2e-48
UniRef50_C0XLT5 Dihydrofolate reductase n=3 Tax=Lactobacillus Re...   192   3e-48
UniRef50_Q5P234 Dihydrofolate reductase n=14 Tax=cellular organi...   192   3e-48
UniRef50_B8KL97 Dihydrofolate reductase n=1 Tax=gamma proteobact...   192   4e-48
UniRef50_Q9RR65 Dihydrofolate reductase n=2 Tax=Deinococcus RepI...   192   4e-48
UniRef50_A3N0P3 Dihydrofolate reductase n=6 Tax=Pasteurellaceae ...   191   4e-48
UniRef50_Q2K6G9 Dihydrofolate reductase protein n=3 Tax=Rhizobia...   191   4e-48
UniRef50_C3JBM5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=C...   191   5e-48
UniRef50_P04174 Dihydrofolate reductase n=33 Tax=Neisseriaceae R...   191   5e-48
UniRef50_A1WMP6 Dihydrofolate reductase n=2 Tax=Proteobacteria R...   191   7e-48
UniRef50_A3HTR7 Dihydrofolate reductase n=1 Tax=Algoriphagus sp....   191   9e-48
UniRef50_C4FSY3 Putative uncharacterized protein n=1 Tax=Catonel...   189   2e-47
UniRef50_B3PTQ3 Dihydrofolate reductase protein n=49 Tax=Proteob...   189   3e-47
UniRef50_C6W5S3 Dihydrofolate reductase n=1 Tax=Dyadobacter ferm...   189   3e-47
UniRef50_B1XTJ0 Dihydrofolate reductase n=1 Tax=Polynucleobacter...   189   3e-47
UniRef50_Q03S94 Dihydrofolate reductase n=4 Tax=Lactobacillus Re...   188   7e-47
UniRef50_A1TM51 Dihydrofolate reductase n=4 Tax=cellular organis...   187   1e-46
UniRef50_C7X688 Dihydrofolate reductase n=7 Tax=Bacteroidales Re...   187   1e-46
UniRef50_B3ER85 Putative uncharacterized protein n=1 Tax=Candida...   187   1e-46
UniRef50_C6XMY9 Dihydrofolate reductase n=1 Tax=Hirschia baltica...   186   2e-46
UniRef50_C8X9J8 Dihydrofolate reductase n=1 Tax=Nakamurella mult...   186   2e-46
UniRef50_B8F4S8 Dihydrofolate reductase n=5 Tax=Pasteurellaceae ...   186   2e-46
UniRef50_A8YUW1 Dihydrofolate reductase n=12 Tax=Lactobacillus R...   185   4e-46
UniRef50_Q134B2 Dihydrofolate reductase n=10 Tax=Bradyrhizobiace...   185   4e-46
UniRef50_C6W102 Dihydrofolate reductase n=1 Tax=Dyadobacter ferm...   185   5e-46
UniRef50_D1QNC5 Dihydrofolate reductase n=1 Tax=Prevotella oris ...   184   6e-46
UniRef50_B2TR57 Dihydrofolate reductase n=10 Tax=Clostridium Rep...   184   7e-46
UniRef50_UPI00017452A7 Dihydrofolate reductase n=1 Tax=Verrucomi...   184   7e-46
UniRef50_D0XKH5 Dihydrofolate reductase n=1 Tax=Brevundimonas su...   184   7e-46
UniRef50_Q5HPB1 Dihydrofolate reductase n=24 Tax=Bacilli RepID=D...   184   1e-45
UniRef50_A6L1Q7 Dihydrofolate reductase n=34 Tax=Bacteroidales R...   183   1e-45
UniRef50_B2I6E9 Dihydrofolate reductase n=11 Tax=Xanthomonadacea...   183   2e-45
UniRef50_C1IBP0 Dihydrofolate reductase n=1 Tax=Clostridium sp. ...   182   3e-45
UniRef50_Q1WU16 Dihydrofolate reductase n=5 Tax=Lactobacillus Re...   182   3e-45
UniRef50_C1SJK6 Dihydrofolate reductase n=1 Tax=Denitrovibrio ac...   181   5e-45
UniRef50_C4L1C8 Dihydrofolate reductase region n=2 Tax=Exiguobac...   181   5e-45
UniRef50_B6INW3 Dihydrofolate reductase n=4 Tax=Alphaproteobacte...   181   6e-45
UniRef50_A7IF75 Dihydrofolate reductase n=3 Tax=Rhizobiales RepI...   181   6e-45
UniRef50_B2SDZ8 Dihydrofolate reductase n=19 Tax=Francisella Rep...   181   8e-45
UniRef50_A6GQA5 Dihydrofolate reductase n=1 Tax=Limnobacter sp. ...   181   9e-45
UniRef50_A4BS77 Dihydrofolate reductase n=1 Tax=Nitrococcus mobi...   180   1e-44
UniRef50_B6YRF0 Dihydrofolate reductase n=1 Tax=Candidatus Azoba...   180   1e-44
UniRef50_C8NE93 Dihydrofolate reductase n=24 Tax=Lactobacillales...   180   1e-44
UniRef50_Q6MID1 FolA protein n=1 Tax=Bdellovibrio bacteriovorus ...   179   2e-44
UniRef50_B9LR90 Dihydrofolate reductase region n=2 Tax=Halobacte...   179   2e-44
UniRef50_Q03F97 Dihydrofolate reductase n=2 Tax=Pediococcus RepI...   178   5e-44
UniRef50_B9ECC1 Putative uncharacterized protein n=1 Tax=Macroco...   178   7e-44
UniRef50_Q38WX9 Dihydrofolate reductase n=5 Tax=Lactobacillales ...   177   9e-44
UniRef50_Q2W7P5 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q...   177   1e-43
UniRef50_B5EIA1 Dihydrofolate reductase region n=5 Tax=Geobacter...   177   1e-43
UniRef50_B6BUF2 Dihydrofolate reductase n=1 Tax=beta proteobacte...   176   2e-43
UniRef50_Q044A0 Dihydrofolate reductase n=13 Tax=Lactobacillus R...   176   2e-43
UniRef50_UPI0001C37DF3 dihydrofolate reductase n=1 Tax=Ruminococ...   176   2e-43
UniRef50_Q0C500 Dihydrofolate reductase n=4 Tax=Alphaproteobacte...   176   2e-43
UniRef50_B2ICT5 Dihydrofolate reductase n=2 Tax=Beijerinckiaceae...   175   3e-43
UniRef50_Q3BX85 Dihydrofolate reductase n=6 Tax=Xanthomonas RepI...   175   3e-43
UniRef50_Q5HFZ7 Dihydrofolate reductase n=54 Tax=Staphylococcus ...   175   4e-43
UniRef50_C9MLK6 Dihydrofolate reductase n=2 Tax=Prevotella RepID...   175   5e-43
UniRef50_UPI00016B2267 dihydrofolate reductase n=1 Tax=candidate...   175   5e-43
UniRef50_Q1LSS4 Dihydrofolate reductase n=1 Tax=Baumannia cicade...   174   6e-43
UniRef50_A5VJL0 Dihydrofolate reductase n=8 Tax=Lactobacillus Re...   174   6e-43
UniRef50_Q0AN20 Dihydrofolate reductase n=4 Tax=Alphaproteobacte...   174   7e-43
UniRef50_A6WGF8 Dihydrofolate reductase n=5 Tax=Actinomycetales ...   174   9e-43
UniRef50_A0PY39 Dihydrofolate reductase n=3 Tax=Clostridium RepI...   174   1e-42
UniRef50_A4VUL2 Dihydrofolate reductase n=9 Tax=Streptococcus Re...   174   1e-42
UniRef50_A0Z2N0 Dihydrofolate reductase n=2 Tax=unclassified Gam...   173   1e-42
UniRef50_C8WCM1 Dihydrofolate reductase region n=4 Tax=Zymomonas...   173   2e-42
UniRef50_A1SJ32 Dihydrofolate reductase n=1 Tax=Nocardioides sp....   173   2e-42
UniRef50_B9XJM4 Dihydrofolate reductase n=1 Tax=bacterium Ellin5...   173   2e-42
UniRef50_Q0SWS9 Dihydrofolate reductase n=1 Tax=Clostridium perf...   172   3e-42
UniRef50_D1PCZ0 Dihydrofolate reductase n=1 Tax=Prevotella copri...   172   4e-42
UniRef50_C7NFY1 Dihydrofolate reductase n=3 Tax=Actinomycetales ...   171   5e-42
UniRef50_Q5V600 Dihydrofolate reductase 2 n=1 Tax=Haloarcula mar...   171   6e-42
UniRef50_A0JZC8 Dihydrofolate reductase n=11 Tax=Bacteria RepID=...   171   7e-42
UniRef50_B8HHJ9 Dihydrofolate reductase n=2 Tax=Micrococcineae R...   171   9e-42
UniRef50_C6XGC7 Dihydrofolate reductase protein n=1 Tax=Candidat...   170   1e-41
UniRef50_Q0TV23 Dihydrofolate reductase n=8 Tax=Clostridium perf...   169   2e-41
UniRef50_D1PWR8 Dihydrofolate reductase n=1 Tax=Prevotella berge...   169   2e-41
UniRef50_A7SCT0 Predicted protein n=2 Tax=Nematostella vectensis...   169   2e-41
UniRef50_C2MBL2 Dihydrofolate reductase n=1 Tax=Porphyromonas ue...   169   2e-41
UniRef50_D0VXF2 Putative uncharacterized protein dfrP n=1 Tax=Ba...   169   3e-41
UniRef50_Q14P23 Putative dihydrofolate reductase oxidoreductase ...   169   4e-41
UniRef50_B7H0P5 Dihydrofolate reductase type 3(Dihydrofolate red...   168   4e-41
UniRef50_C7H0N2 Dihydrofolate reductase n=1 Tax=Eubacterium saph...   168   4e-41
UniRef50_Q54801 Dihydrofolate reductase n=65 Tax=Streptococcus R...   168   4e-41
UniRef50_Q18HG9 Dihydrofolate reductase n=4 Tax=Halobacteriaceae...   168   5e-41
UniRef50_Q5M5B2 Dihydrofolate reductase n=9 Tax=Streptococcus Re...   168   5e-41
UniRef50_C3RMT4 Dihydrofolate reductase n=4 Tax=Bacteria RepID=C...   167   7e-41
UniRef50_Q59408 Dihydrofolate reductase type A13 n=57 Tax=Bacter...   167   8e-41
UniRef50_Q9U8B8 Dihydrofolate reductase n=1 Tax=Heliothis viresc...   167   9e-41
UniRef50_P00380 Dihydrofolate reductase n=1 Tax=Enterococcus fae...   167   1e-40
UniRef50_C3XD45 Dihydrofolate reductase n=2 Tax=Oxalobacter form...   167   1e-40
UniRef50_D2LGH8 Dihydrofolate reductase n=1 Tax=Rhodomicrobium v...   167   1e-40
UniRef50_D0J8Z9 Dihydrofolate reductase n=2 Tax=Blattabacterium ...   166   2e-40
UniRef50_B1MYC2 Dihydrofolate reductase n=3 Tax=Leuconostoc RepI...   166   2e-40
UniRef50_Q1GFV5 Dihydrofolate reductase n=18 Tax=Rhodobacterales...   166   2e-40
UniRef50_UPI0001874368 dihydrofolate reductase n=1 Tax=Corynebac...   166   2e-40
UniRef50_C2HC06 Dihydrofolate reductase n=11 Tax=Enterococcus fa...   166   2e-40
UniRef50_C4Z3U6 Dihydrofolate reductase n=8 Tax=Firmicutes RepID...   166   2e-40
UniRef50_Q6A328 Dihydrofolate reductase n=1 Tax=Pasteurella mult...   165   4e-40
UniRef50_Q8D3H9 FolA protein n=1 Tax=Wigglesworthia glossinidia ...   165   4e-40
UniRef50_B2GC42 Dihydrofolate reductase n=4 Tax=Lactobacillus Re...   165   4e-40
UniRef50_UPI0001C35E5E dihydrofolate reductase region n=1 Tax=Cl...   164   6e-40
UniRef50_C5NYS7 Dihydrofolate reductase n=1 Tax=Gemella haemolys...   164   6e-40
UniRef50_C3Z0P2 Putative uncharacterized protein n=2 Tax=Deutero...   164   6e-40
UniRef50_Q7UIC9 Dihydrofolate reductase n=1 Tax=Rhodopirellula b...   164   9e-40
UniRef50_B8DW85 Dihydrofolate reductase n=6 Tax=Bifidobacterium ...   164   1e-39
UniRef50_UPI00016BFCBD Dihydrofolate reductase n=1 Tax=Epulopisc...   164   1e-39
UniRef50_D1BYH5 Dihydrofolate reductase n=1 Tax=Xylanimonas cell...   164   1e-39
UniRef50_A3K5B9 Dihydrofolate reductase n=1 Tax=Sagittula stella...   163   2e-39
UniRef50_Q89AV2 Dihydrofolate reductase n=5 Tax=Buchnera aphidic...   163   2e-39
UniRef50_Q3A0W8 Dihydrofolate reductase n=1 Tax=Pelobacter carbi...   163   2e-39
UniRef50_B0MRL8 Putative uncharacterized protein n=1 Tax=Eubacte...   163   2e-39
UniRef50_C5CC92 Dihydrofolate reductase n=3 Tax=Actinobacteria (...   163   2e-39
UniRef50_B2UP70 Dihydrofolate reductase n=1 Tax=Akkermansia muci...   162   3e-39
UniRef50_C7R3F1 Dihydrofolate reductase n=1 Tax=Jonesia denitrif...   162   3e-39
UniRef50_Q3F0Y0 Dihydrofolate reductase n=2 Tax=Bacillus thuring...   162   3e-39
UniRef50_C4Z7Z2 Dihydrofolate reductase n=34 Tax=Bacteria RepID=...   162   4e-39
UniRef50_A5WHY1 Dihydrofolate reductase n=4 Tax=Moraxellaceae Re...   162   4e-39
UniRef50_Q494F1 Dihydrofolate reductase type I n=1 Tax=Candidatu...   161   6e-39
UniRef50_C4WVU0 ACYPI002804 protein n=1 Tax=Acyrthosiphon pisum ...   161   7e-39
UniRef50_UPI000006EBF1 PREDICTED: hypothetical protein XP_002346...   161   9e-39
UniRef50_Q9CBW1 Dihydrofolate reductase n=25 Tax=Actinomycetales...   161   9e-39
UniRef50_Q2S5H3 Dihydrofolate reductase n=3 Tax=cellular organis...   160   1e-38
UniRef50_Q93341 Putative dihydrofolate reductase n=2 Tax=Caenorh...   159   2e-38
UniRef50_B0VHY5 Dihydrofolate reductase n=1 Tax=Candidatus Cloac...   159   2e-38
UniRef50_D2Q8R3 DfrA Dihydrofolate reductase n=12 Tax=Bifidobact...   159   3e-38
UniRef50_C1C2C0 Dihydrofolate reductase n=1 Tax=Caligus clemensi...   159   3e-38
UniRef50_C9KQJ5 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin...   159   3e-38
UniRef50_Q59487 Dihydrofolate reductase n=17 Tax=Streptococcacea...   159   3e-38
UniRef50_Q13PE2 Dihydrofolate reductase n=1 Tax=Burkholderia xen...   159   4e-38
UniRef50_B7C7C2 Putative uncharacterized protein n=1 Tax=Eubacte...   158   4e-38
UniRef50_D2RRK6 Dihydrofolate reductase n=1 Tax=Haloterrigena tu...   157   7e-38
UniRef50_A1WYQ0 Dihydrofolate reductase n=1 Tax=Halorhodospira h...   157   9e-38
UniRef50_C0QWN0 Dihydrofolate reductase n=2 Tax=Brachyspira RepI...   157   1e-37
UniRef50_P17719 Dihydrofolate reductase n=21 Tax=Endopterygota R...   157   1e-37
UniRef50_C7N8V9 Dihydrofolate reductase region n=5 Tax=Fusobacte...   157   1e-37
UniRef50_B3RI81 Putative uncharacterized protein n=1 Tax=Trichop...   157   1e-37
UniRef50_P00374 Dihydrofolate reductase n=50 Tax=root RepID=DYR_...   157   1e-37
UniRef50_UPI00015B4DEB PREDICTED: similar to conserved hypotheti...   156   2e-37
UniRef50_D1YEK5 Dihydrofolate reductase n=3 Tax=Propionibacteriu...   156   3e-37
UniRef50_C3PEY4 Dihydrofolate reductase n=9 Tax=Corynebacterium ...   156   3e-37
UniRef50_C7REN4 Dihydrofolate reductase region n=2 Tax=Anaerococ...   155   3e-37
UniRef50_C7XU42 Dihydrofolate reductase n=1 Tax=Lactobacillus co...   155   4e-37
UniRef50_Q0G0R9 Dihydrofolate reductase n=2 Tax=Aurantimonadacea...   155   4e-37
UniRef50_B9DU71 Dihydrofolate reductase n=13 Tax=Streptococcus R...   155   4e-37
UniRef50_C8WAC3 Dihydrofolate reductase region n=5 Tax=Coriobact...   155   4e-37
UniRef50_B9YFM0 Dihydrofolate reductase region n=3 Tax=Nostocace...   154   8e-37
UniRef50_C4QMV9 Dihydrofolate reductase n=1 Tax=Schistosoma mans...   154   8e-37
UniRef50_C2CJZ1 Possible dihydrofolate reductase n=3 Tax=Anaeroc...   154   1e-36
UniRef50_C0EGY7 Putative uncharacterized protein n=1 Tax=Clostri...   153   2e-36
UniRef50_UPI000186EC32 Dihydrofolate reductase, putative n=1 Tax...   153   2e-36
UniRef50_B4D395 Dihydrofolate reductase region n=1 Tax=Chthoniob...   152   3e-36
UniRef50_C4V3M4 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphoki...   152   4e-36
UniRef50_C5BYZ5 Dihydrofolate reductase n=1 Tax=Beutenbergia cav...   152   4e-36
UniRef50_C8NZB9 Dihydrofolate reductase n=1 Tax=Erysipelothrix r...   152   5e-36
UniRef50_P78218 Dihydrofolate reductase type 15 n=153 Tax=root R...   152   5e-36
UniRef50_A3DES9 Dihydrofolate reductase n=5 Tax=Clostridium RepI...   151   5e-36
UniRef50_D2SDU7 Dihydrofolate reductase n=1 Tax=Geodermatophilus...   151   5e-36
UniRef50_Q934V0 Putative dihydrofolate reductase n=1 Tax=Salmone...   151   6e-36
UniRef50_Q4JX60 FolA protein n=3 Tax=Corynebacterium RepID=Q4JX6...   151   6e-36
UniRef50_UPI0001926A4C PREDICTED: similar to Dihydrofolate reduc...   151   7e-36
UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraure...   151   9e-36
UniRef50_A9HP20 Dihydrofolate reductase n=1 Tax=Roseobacter lito...   150   1e-35
UniRef50_Q8JKV3 Dihydrofolate reductase n=1 Tax=Heliothis zea vi...   150   1e-35
UniRef50_P00381 Dihydrofolate reductase n=9 Tax=Lactobacillus Re...   149   2e-35
UniRef50_C5IWK1 Dihydrofolate reductase n=15 Tax=Bacteria RepID=...   149   2e-35
UniRef50_Q7VQK5 Dihydrofolate reductase type I n=1 Tax=Candidatu...   148   5e-35
UniRef50_C5RC79 Dihydrofolate reductase n=1 Tax=Weissella parame...   148   5e-35
UniRef50_B2GI60 Dihydrofolate reductase n=3 Tax=Actinomycetales ...   148   5e-35
UniRef50_P11731 Dihydrofolate reductase type 5 n=27 Tax=Bacteria...   147   8e-35
UniRef50_C0VZ67 Possible dihydrofolate reductase n=3 Tax=Actinom...   147   9e-35
UniRef50_C2D6N3 Possible dihydrofolate reductase n=1 Tax=Atopobi...   147   1e-34
UniRef50_Q86ZU9 Dihydrofolate reductase n=2 Tax=Agaricales RepID...   147   1e-34
UniRef50_UPI000180BE95 PREDICTED: similar to GJ10259 n=1 Tax=Cio...   147   1e-34
UniRef50_B7VPW7 Dihydrofolate reductase type I (Trimethoprim res...   146   2e-34
UniRef50_A4GI75 Dihydrofolate reductase n=1 Tax=uncultured marin...   146   3e-34
UniRef50_Q59397 Dihydrofolate reductase type 9 n=1 Tax=Escherich...   146   3e-34
UniRef50_D1AYS8 Dihydrofolate reductase region n=1 Tax=Streptoba...   146   3e-34
UniRef50_A8SSS6 Putative uncharacterized protein n=2 Tax=Bacteri...   145   4e-34
UniRef50_P27422 Dihydrofolate reductase type 7 n=46 Tax=Bacteria...   145   4e-34
UniRef50_Q53D67 JM3 n=3 Tax=Macacine herpesvirus 5 RepID=Q53D67_...   145   5e-34
UniRef50_P15093 Dihydrofolate reductase n=3 Tax=Halobacteriaceae...   145   5e-34
UniRef50_Q4SM73 Chromosome 13 SCAF14555, whole genome shotgun se...   144   8e-34
UniRef50_A8SNM7 Putative uncharacterized protein n=1 Tax=Parvimo...   144   8e-34
UniRef50_C5VBQ6 Dihydrofolate reductase n=5 Tax=Corynebacterium ...   144   8e-34
UniRef50_Q8EV82 Dihyrofolate reductase n=1 Tax=Mycoplasma penetr...   144   1e-33
UniRef50_UPI00017450E9 dihydrofolate reductase type III n=1 Tax=...   144   1e-33

Sequences not found previously or not previously below threshold:

>UniRef50_P11045 Dihydrofolate reductase n=23 Tax=Firmicutes RepID=DYR_BACSU
          Length = 168

 Score =  228 bits (582), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 70/160 (43%), Positives = 102/160 (63%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS I A+  +R+IG +N +PW+LP DLA+FK+ T    +IMGR T+ESIGRPLP RKNI
Sbjct: 1   MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGRKTFESIGRPLPNRKNI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++S P ++    T V S+ + +  C    E  VIGG ++Y    P A +LY+T I  E 
Sbjct: 61  VVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYTDLFPYADRLYMTKIHHEF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD HFP+++  +W+ V SE    D +N + Y F + E++
Sbjct: 121 EGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK 160


>UniRef50_A7Z5T2 DfrA n=2 Tax=Bacillaceae RepID=A7Z5T2_BACA2
          Length = 161

 Score =  223 bits (569), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 59/160 (36%), Positives = 91/160 (56%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS I A+  +R+IG +N +PW+LP DLA+FK+ T    ++MGR T+ESIGRPLP R+NI
Sbjct: 1   MISFIFAMDENRLIGKDNDLPWHLPDDLAYFKKVTTGHTIVMGRKTFESIGRPLPNRRNI 60

Query: 61  ILS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++     +        S +E +       E  VIGG ++Y    P A +LY+T I    
Sbjct: 61  VVTSRDESSFPGCITADSAEEVLKLIPADEECFVIGGAQLYSALFPYADRLYMTKIHHVF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD  FP++   +WE    +    D +N + Y + + E++
Sbjct: 121 EGDRFFPEFNEAEWELTSRKQGVKDEKNPYDYEYLVYEKK 160


>UniRef50_Q65IB5 DfrA n=4 Tax=Bacillaceae RepID=Q65IB5_BACLD
          Length = 162

 Score =  219 bits (558), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 71/161 (44%), Positives = 98/161 (60%), Gaps = 2/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAA+  +R+IG +N +PW+LP DL +FK  T    VIMGR T+ESIGRPLP R+NI
Sbjct: 1   MISLIAAMDRNRLIGKDNDLPWHLPQDLKYFKEVTKGHAVIMGRKTFESIGRPLPHRENI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           I++S    D      + S +EA+    +   E  VIGG  +Y + LP A KLY+T ID  
Sbjct: 61  IVTSNKELDIPNCQVMHSAEEAVRFAKNRNEECFVIGGSTLYTEILPFADKLYVTKIDET 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD +FP++   +WE V       D +N + Y F + +R+
Sbjct: 121 FEGDRYFPEFSEAEWEIVSRRKGLKDDKNPYDYEFLVYQRK 161


>UniRef50_B0MUX5 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM
           17216 RepID=B0MUX5_9BACT
          Length = 160

 Score =  218 bits (556), Expect = 5e-56,   Method: Composition-based stats.
 Identities = 62/159 (38%), Positives = 97/159 (61%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI++I A+A + VIG +N + W++  DL  FK  T   PV+MGR T+ES+GRPLPGR+N+
Sbjct: 1   MIAIIVAVAENGVIGGDNRLLWHISEDLKHFKAVTTGHPVVMGRKTYESLGRPLPGRRNV 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +++ Q  + +    V S+DEA+A      ++ VIGG ++Y Q LP   + YLT +    +
Sbjct: 61  VVTRQNISIEGCDVVHSLDEALALFRPEEKVFVIGGAQIYAQALPLCDEFYLTRVFHAYQ 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FP ++  +WE + SE   +  +  + + FE   RR
Sbjct: 121 GDTCFPRWDEREWEIIDSESFASGKEFPYPFAFEHYRRR 159


>UniRef50_P0ABQ5 Dihydrofolate reductase n=111 Tax=Enterobacteriaceae
           RepID=DYR_ECOL6
          Length = 159

 Score =  217 bits (553), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 159/159 (100%), Positives = 159/159 (100%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI
Sbjct: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
Sbjct: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159


>UniRef50_P12833 Dihydrofolate reductase type 3 n=26 Tax=Proteobacteria
           RepID=DYR3_SALTY
          Length = 162

 Score =  217 bits (553), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 82/160 (51%), Positives = 112/160 (70%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAALA + +IG +N +PW+LPADL  FK  TL KPV+MGR T+ESIGRPLPGR+N+
Sbjct: 2   LISLIAALAHNNLIGKDNLIPWHLPADLRHFKAVTLGKPVVMGRRTFESIGRPLPGRRNV 61

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S  P    + V    S+D A+A   D  E M+IGGG++Y + LP+A +LYLT+IDA++
Sbjct: 62  VVSRNPQWQAEGVEVAPSLDAALALLTDCEEAMIIGGGQLYAEALPRADRLYLTYIDAQL 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GDTHFPDY    W+ +    H AD +NS++  F  L R+
Sbjct: 122 NGDTHFPDYLSLGWQELERSTHPADDKNSYACEFVTLSRQ 161


>UniRef50_D0U4K0 Dihydrofolate reductase n=2 Tax=uncultured SUP05 cluster bacterium
           RepID=D0U4K0_9GAMM
          Length = 179

 Score =  216 bits (551), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 72/158 (45%), Positives = 102/158 (64%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A+  +++IG  NA+PW+LPADL +FK+ T  K V+MGR T+ESIGRPLP R+N+I
Sbjct: 21  LSIIVAMDDNQLIGKNNALPWHLPADLGYFKKVTTGKTVLMGRKTYESIGRPLPNRRNVI 80

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S       D    V S+D A+    D  E+MV+GG   YEQ LP   +LY+T I+ E +
Sbjct: 81  VSRNTNFKADGCEVVSSIDAALKLAKDDSEVMVMGGASFYEQMLPSVDRLYITQIEGEYQ 140

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD HFP ++   +  V  E H AD +N ++Y F IL+R
Sbjct: 141 GDAHFPKFDRGKFSEVSRESHTADEKNQYTYHFTILDR 178


>UniRef50_D2QJY0 Dihydrofolate reductase n=2 Tax=Bacteria RepID=D2QJY0_9SPHI
          Length = 163

 Score =  213 bits (542), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 71/160 (44%), Positives = 103/160 (64%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAA+A + VIG EN +PW+LP D A+FKR T + P+IMGR + ES+G+PLP R NI+
Sbjct: 3   ISLIAAVAQNGVIGRENDLPWHLPDDFAFFKRKTSHHPIIMGRKSLESLGKPLPNRTNIV 62

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           L+         VT V ++D+AIA     +  EI VIGG  +Y+  LP A  LYLT I  +
Sbjct: 63  LTRNAEFSAAGVTIVHTLDDAIAEAKAINQTEIFVIGGAEIYKMALPIATTLYLTEIHQD 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            +GD +FP+++ ++W+ V    H AD +++ S+ F   E+
Sbjct: 123 YDGDAYFPEFDKNEWQEVSRRPHPADERHAVSFDFVEYEK 162


>UniRef50_Q1LK80 Dihydrofolate reductase n=3 Tax=Proteobacteria RepID=Q1LK80_RALME
          Length = 166

 Score =  213 bits (542), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 66/159 (41%), Positives = 92/159 (57%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +++LI A A + VIG  N +PW LP DL  FKR T+  P+IMGR TW+SIGRPLPGR+NI
Sbjct: 3   LLTLIVARARNGVIGRNNTLPWRLPEDLQHFKRTTMGAPIIMGRKTWDSIGRPLPGRRNI 62

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++       +    V S+++A   C    ++ +IGG ++Y + LP A +L +T IDA+V
Sbjct: 63  VVTRNRDLHIEGADVVGSIEDAQRLCIGAEQVFLIGGAQLYAEALPSADRLIVTEIDADV 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGD  FP  +   W     E H     N   Y F   ER
Sbjct: 123 EGDAFFPAVDRTTWVETARELH-HSETNGFDYAFVTYER 160


>UniRef50_P27498 Dihydrofolate reductase n=89 Tax=Gammaproteobacteria
           RepID=DYR_KLEAE
          Length = 159

 Score =  212 bits (540), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 142/159 (89%), Positives = 152/159 (95%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLIAAL VDRVIGMENAMPWNL  DLAWFKRNTLNKPV+MGR TWESIGRPLPGRKNI
Sbjct: 1   MISLIAALRVDRVIGMENAMPWNLNEDLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++SS+PG+DDRV WV SV+EAIAACGDV EIMVIGGGRVY++FLPKAQKLYLTHIDAEVE
Sbjct: 61  VISSKPGSDDRVQWVSSVEEAIAACGDVEEIMVIGGGRVYDEFLPKAQKLYLTHIDAEVE 120

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDTHFPDY+PD+WESVFSEFHDADAQNSHSYCFEILERR
Sbjct: 121 GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR 159


>UniRef50_A9I779 FolA protein n=2 Tax=Bordetella RepID=A9I779_BORPD
          Length = 178

 Score =  209 bits (534), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 69/159 (43%), Positives = 95/159 (59%), Gaps = 3/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++L+ A + +RVIG +N +PW LP DLA FKR TL  P+IMGR TWES+GRPLPGR N++
Sbjct: 21  LTLVVAYSDNRVIGRDNTLPWKLPGDLAHFKRTTLGSPIIMGRKTWESLGRPLPGRTNVV 80

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S          T V ++  A+ ACGD P+  VIGG ++Y Q LP A ++  T + A VE
Sbjct: 81  ISRNLRYAAPGATVVPTLQAAVEACGDAPDAYVIGGAQIYAQALPLAARVIATEVHAHVE 140

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GD  FP      W     +   A  +N + Y F + ER+
Sbjct: 141 GDAFFPYLPSFAWREASRQPQPA--ENGYDYDFVVYERQ 177


>UniRef50_A1U3D7 Dihydrofolate reductase n=6 Tax=Gammaproteobacteria
           RepID=A1U3D7_MARAV
          Length = 171

 Score =  209 bits (533), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 69/164 (42%), Positives = 100/164 (60%), Gaps = 8/164 (4%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           +LI A+A +RVIG  N +PW LP DL +FK+ T+ KP+IMGR TW+SIGRPLPGR N+++
Sbjct: 4   ALIVAMARNRVIGRNNKLPWYLPGDLRYFKQATMGKPIIMGRKTWDSIGRPLPGRMNVVI 63

Query: 63  SSQP--GTDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           S  P            S++EA+      A      E+M+IGGG++Y + LP   ++Y+T 
Sbjct: 64  SRNPEWQAPAGTVAAASLNEALVKAEAQANLEGGDEVMIIGGGQIYAEALPMVDRIYITQ 123

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + AEV+GD  FP+   D+WE +  E   A   N + Y F + +R
Sbjct: 124 VHAEVDGDAFFPEVNWDEWEEIGREDFSASDNNPYDYSFVVYQR 167


>UniRef50_D0KZ69 Dihydrofolate reductase n=2 Tax=Gammaproteobacteria
           RepID=D0KZ69_HALNC
          Length = 177

 Score =  208 bits (530), Expect = 5e-53,   Method: Composition-based stats.
 Identities = 82/159 (51%), Positives = 104/159 (65%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I L+AAL  ++VIG  NA+PW+LPADL  FK+ T+ KP+IMGR T++SIGRPLPGRKNI+
Sbjct: 3   IGLVAALTRNQVIGRYNALPWSLPADLQRFKKITMGKPIIMGRKTYDSIGRPLPGRKNIV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119
           +S  P    D VT V S+D A+ A    PE+MVIGG  +Y QFLP+A +LY T +   + 
Sbjct: 63  ISRNPDFHADGVTVVDSLDMALEAADQAPEVMVIGGANIYYQFLPRADRLYFTLVHTTID 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GD  FP Y   DW  V  E H ADA N   Y F   +R
Sbjct: 123 DGDAFFPAYNRRDWRLVIEENHPADADNPFPYSFMTWQR 161


>UniRef50_A9KH09 Dihydrofolate reductase n=8 Tax=Coxiella burnetii
           RepID=A9KH09_COXBN
          Length = 161

 Score =  208 bits (530), Expect = 5e-53,   Method: Composition-based stats.
 Identities = 67/159 (42%), Positives = 106/159 (66%), Gaps = 1/159 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +I+LIAA+  +R+IG  N +PW+LPADLA FK  TL KP++MGR T++SIG+PLP R+NI
Sbjct: 2   IITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSIGKPLPHRRNI 61

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++ Q     +      S+D+A++A    PE+++IGG R++++ LPKA K+ LT I+   
Sbjct: 62  VITQQKNLIIEGCDIFYSLDDALSALTKEPEVIIIGGARIFKEALPKADKMILTIINHSF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGD +FP++   +W+      H+ D +N + + F  L R
Sbjct: 122 EGDVYFPEWNDKEWKITSQIKHERDEKNPYPFQFLELRR 160


>UniRef50_A4Y040 Dihydrofolate reductase n=28 Tax=Proteobacteria RepID=A4Y040_PSEMY
          Length = 176

 Score =  208 bits (530), Expect = 6e-53,   Method: Composition-based stats.
 Identities = 79/165 (47%), Positives = 103/165 (62%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAALA +RVIG +N +PW+LPADL  FK  TL KP+IMGR TW+S+GRPLPGR NI+
Sbjct: 11  LSLIAALADNRVIGRDNQLPWHLPADLKHFKALTLGKPIIMGRKTWDSLGRPLPGRLNIV 70

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S Q G T +      +++EAI          D  E+M+IGG ++YE  L +A +LYLT 
Sbjct: 71  VSRQAGLTLEGAEVFATLEEAIKRADAWAREEDAEELMLIGGAQLYELGLEQADRLYLTR 130

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +  E EGD  FP  +   W    S  H A A+    Y FE+ ERR
Sbjct: 131 VGLEPEGDAFFPQIDESAWRMTSSVEHPASAETPF-YAFEVWERR 174


>UniRef50_P43791 Dihydrofolate reductase n=19 Tax=Gammaproteobacteria
           RepID=DYR_HAEIN
          Length = 160

 Score =  206 bits (526), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 84/158 (53%), Positives = 107/158 (67%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
            SLI A  ++ VIG +N MPW+LPADLAWF++NT  KPVIMGR T+ESIGRPLP R NI+
Sbjct: 3   FSLIVATTLNNVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           LS Q    + V W  S + A+    D  EIM+IGGG +++Q+LPKA KLYLT I  E++G
Sbjct: 63  LSRQLFEHEGVIWKDSFESAVNFVRDFDEIMLIGGGELFKQYLPKADKLYLTQIQTELDG 122

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DT FP    ++WE  F E+  AD QN +   F IL R+
Sbjct: 123 DTFFPQLNWEEWEIEFDEYRKADEQNRYDCRFLILTRK 160


>UniRef50_A5FJX2 Dihydrofolate reductase n=1 Tax=Flavobacterium johnsoniae UW101
           RepID=A5FJX2_FLAJ1
          Length = 160

 Score =  206 bits (526), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 59/160 (36%), Positives = 90/160 (56%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI +IAA+A +  +G  N + W+LP D   FK  T N  +IMGR T+ES  +PLP R +I
Sbjct: 1   MIIMIAAVAENNTLGKNNELVWHLPNDFKRFKSLTTNHHIIMGRKTFESFPKPLPNRTHI 60

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++ Q     +    V S+++AIAAC +  +  +IGGG +Y   LP A  + +T +    
Sbjct: 61  IITRQTDYNPEGCIVVDSMEKAIAACPENEDSYIIGGGEIYNLGLPYADIIEITKVHHTF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD  FP     +W+ V SE +  D ++ + Y +E   R+
Sbjct: 121 EGDAFFPKISKSEWQLVESEENFKDEKHLYDYTYETYIRK 160


>UniRef50_A0AJX9 DfrA protein n=15 Tax=Listeria RepID=A0AJX9_LISW6
          Length = 160

 Score =  206 bits (525), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 60/159 (37%), Positives = 90/159 (56%), Gaps = 1/159 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI  + A      IG +N MPW+LP DL +FK+ T  K ++MGR T+ES+G+ LP RK I
Sbjct: 1   MIIFVWAQDRAGNIGKDNTMPWHLPGDLQFFKKTTTGKTLVMGRKTYESLGKALPNRKTI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L+       D    + S +E +A       I V+GG  +Y  F+  A KL +T IDAE 
Sbjct: 61  VLTRDKELQLDDAEILHSREEVLALTQTGEPIYVVGGAEIYRLFMDVADKLIVTKIDAEF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + DT FP+ + +++  +  E H+ D +N ++Y F   ER
Sbjct: 121 DADTAFPEVDWENFSEIAKEPHEKDEKNKYNYTFYTYER 159


>UniRef50_C6P459 Dihydrofolate reductase n=1 Tax=Sideroxydans lithotrophicus ES-1
           RepID=C6P459_9PROT
          Length = 177

 Score =  205 bits (522), Expect = 4e-52,   Method: Composition-based stats.
 Identities = 54/158 (34%), Positives = 83/158 (52%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLI A+A +R IG+ N +PW  P DL  FK  T+   +IMGR T++SIG+PLPGR  ++
Sbjct: 19  LSLIVAMARNRTIGVNNTLPWRCPEDLKHFKTLTMGHHMIMGRKTFDSIGKPLPGRTTVV 78

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++     + +      S+ EA+  C    EI V+GG  +Y Q +     LY+T I  +V 
Sbjct: 79  ITRNNDLEIEGCIVAHSLQEALVTCAGDEEIFVVGGAELYRQAISLVDTLYVTEIQQDVA 138

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD HFP+ +   W+    E    +      + F    +
Sbjct: 139 GDAHFPEIDKAFWQETSREMRSQETPQPMDFHFVTYRK 176


>UniRef50_Q3JEI1 Dihydrofolate reductase n=3 Tax=Gammaproteobacteria
           RepID=Q3JEI1_NITOC
          Length = 165

 Score =  204 bits (521), Expect = 6e-52,   Method: Composition-based stats.
 Identities = 71/159 (44%), Positives = 103/159 (64%), Gaps = 1/159 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS I A+  + +IG    +PW+LPADL +F+R T+ KP++MGR T E+IGRPLPGR NI
Sbjct: 2   IISFIVAMDENHLIGANRRLPWHLPADLKYFRRMTMGKPMLMGRSTHEAIGRPLPGRHNI 61

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++  P       T V +V+  + A G+  E+ VIGG  +YEQ LP+A+++YLT +    
Sbjct: 62  VVTHNPDYKAPGCTVVHTVEAGLQAAGEAEEVTVIGGASLYEQLLPQARRIYLTLVRGHF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +GDT FP ++P  W  V+ E +D D QN + Y F  LER
Sbjct: 122 QGDTWFPAFDPGTWVEVWREDYDPDPQNPYPYSFIRLER 160


>UniRef50_C2FZ23 Dihydrofolate reductase n=2 Tax=Sphingobacterium spiritivorum
           RepID=C2FZ23_9SPHI
          Length = 164

 Score =  204 bits (521), Expect = 6e-52,   Method: Composition-based stats.
 Identities = 70/159 (44%), Positives = 96/159 (60%), Gaps = 1/159 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+LI A A + VIG +N MPW+LP D  +FK+NTL   VIMGR T+E+IG+ LP R+NI+
Sbjct: 6   ITLIVAAAENNVIGKDNQMPWHLPNDFKYFKKNTLEHSVIMGRKTFEAIGKALPDRRNIV 65

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S         V    S+ EAI  C D  E+ VIGG  +YEQ LP A K+ LT +   +E
Sbjct: 66  ISRNQDFHHPDVDTANSLQEAILYCRDEREVFVIGGANIYEQTLPFAHKVLLTRVHTTIE 125

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GD  FP   P++W     E H AD +++  Y F++  R+
Sbjct: 126 GDAVFPVLNPEEWMLESEEKHFADDKHAFDYTFQVFNRK 164


>UniRef50_Q31I54 Dihydrofolate reductase n=32 Tax=Bacteria RepID=Q31I54_THICR
          Length = 175

 Score =  204 bits (519), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 73/160 (45%), Positives = 113/160 (70%), Gaps = 2/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           IS+IAA+   R+IG +N MPW+LP DL +FK NT+NKPVIMGR T+ESIG +PLP R+N+
Sbjct: 14  ISMIAAMDKHRIIGADNDMPWHLPDDLKFFKANTVNKPVIMGRKTFESIGSKPLPNRRNL 73

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++     + +      S +EA+ +C    EI+++GGG++Y Q +P A KLY+T +DAEV
Sbjct: 74  VITRNDAYEANGAEVFHSAEEALKSCKSEVEIIIMGGGQLYAQMMPFANKLYVTLVDAEV 133

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GDT FP++  D+W+ +  E+HD D ++++++ F  L R+
Sbjct: 134 AGDTTFPEWLTDEWQEISKEWHDKDERHAYAFEFVTLIRK 173


>UniRef50_Q2SXY8 Dihydrofolate reductase n=18 Tax=Proteobacteria RepID=Q2SXY8_BURTA
          Length = 219

 Score =  203 bits (517), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 67/161 (41%), Positives = 95/161 (59%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A A + VIG +N +PW LP DLA+FKR T+  P++MGR T ESIGRPLPGR+NI+
Sbjct: 56  LTLIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 115

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D      S+ +A+A        E  +IGG ++Y + L  A KL +T ID +
Sbjct: 116 VTRDAARRFDGCDTATSLGDALALAERDGAAEAFLIGGAQLYAEGLRHADKLIVTEIDQD 175

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD  FP  +P  WE+V  + H A   N  +Y F +  R+
Sbjct: 176 FEGDASFPAPDPAQWEAVSRDAHRAAPPNDFAYAFVVYRRK 216


>UniRef50_Q2Y7L3 Dihydrofolate reductase n=7 Tax=Betaproteobacteria
           RepID=Q2Y7L3_NITMU
          Length = 183

 Score =  203 bits (516), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 70/169 (41%), Positives = 102/169 (60%), Gaps = 14/169 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S++ A+A +R IG +NA+PW+LP DL  FK  T+  P+IMGR T+ESIGR LPGR +II
Sbjct: 5   LSVLVAMARNRAIGHKNAIPWHLPHDLKHFKELTMGHPMIMGRKTYESIGRLLPGRTSII 64

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDV-----------PEIMVIGGGRVYEQFLPKAQK 109
           ++ QP  +      V S+ EA++AC  +            E  VIGG  +++Q LP   +
Sbjct: 65  ITRQPDYEVPGALVVSSIGEALSACKQIRSGEEGHPDQGNECFVIGGADIFQQMLPLCDR 124

Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           LY+T I  + EGDT+FP+++ +DW  V  E H  D+     Y F  L+R
Sbjct: 125 LYMTEIHRDFEGDTYFPEFDRNDWWEVSREEHVDDS--GLEYHFVTLDR 171


>UniRef50_C6X2F4 Dihydrofolate reductase n=20 Tax=Bacteroidetes RepID=C6X2F4_FLAB3
          Length = 167

 Score =  202 bits (514), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 61/161 (37%), Positives = 93/161 (57%), Gaps = 2/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI+++ A+ +   IG +N + W+LP DL  FK  T   P+IMGR T+ESIGRPLP R NI
Sbjct: 1   MITIVVAMGLKNEIGADNQLLWHLPQDLKHFKEITTGHPIIMGRKTYESIGRPLPNRTNI 60

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++S +     + V  V S+ EA+     + E + VIGGG +YEQ +  A KL +T + AE
Sbjct: 61  VVSRKKDWFAEGVLIVGSLKEALKFAKKIDENVFVIGGGNIYEQTIDLADKLEVTLVKAE 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +  D  FP  +   WE       D D ++++ +CF+   ++
Sbjct: 121 INADIFFPKIDLKIWEKTSETCIDKDEKHAYDFCFQTFVKK 161


>UniRef50_UPI0001787F40 Dihydrofolate reductase n=1 Tax=Geobacillus sp. Y412MC10
           RepID=UPI0001787F40
          Length = 162

 Score =  202 bits (514), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 71/163 (43%), Positives = 103/163 (63%), Gaps = 5/163 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MIS+I A+  D+VIG+   MPW LP D+A+FK  TL+K ++MGR TW+S G +PLP RKN
Sbjct: 1   MISMIWAMGKDQVIGLNGTMPWRLPRDMAFFKEKTLHKTILMGRKTWDSFGGKPLPHRKN 60

Query: 60  IILSSQPG---TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+L+       T+D+   +  ++ A+    +  E+MVIGG ++YE  LPKA +LY T ID
Sbjct: 61  IVLTRDESFTLTEDQGIVIHDIENALPYSKN-EELMVIGGSQIYELMLPKADRLYCTFID 119

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
              EGDT+FP+   D+W+ V       D +N ++Y F   ER+
Sbjct: 120 ESFEGDTYFPEVNWDEWKIVEEVPGITDEKNPYAYRFVTFERK 162


>UniRef50_Q0VM07 Dihydrofolate reductase n=5 Tax=Gammaproteobacteria
           RepID=Q0VM07_ALCBS
          Length = 171

 Score =  201 bits (512), Expect = 6e-51,   Method: Composition-based stats.
 Identities = 69/165 (41%), Positives = 100/165 (60%), Gaps = 7/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S++ A A + VIG  N +PW LP DL +FK+ T  KPVIMGR TWES+  PLPGR NI+
Sbjct: 7   LSMMVAKATNNVIGRNNKLPWYLPNDLKYFKQVTFGKPVIMGRKTWESLKGPLPGRTNIV 66

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++ QP    +    V +VD+AI    +        E +++GG  +Y   L + Q+LYLT 
Sbjct: 67  ITRQPAYQAEGAKVVATVDDAITMAENVAFIEGQEEAVIMGGAEIYALALAQTQRLYLTE 126

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + AEV+GDT FP+Y+  +WE +  E   A+  N + Y F + ER+
Sbjct: 127 VHAEVDGDTFFPEYDKGEWEEIAREDFPAEGPNPYDYSFVVYERK 171


>UniRef50_A2SN57 Dihydrofolate reductase n=34 Tax=Burkholderiales RepID=A2SN57_METPP
          Length = 259

 Score =  201 bits (511), Expect = 7e-51,   Method: Composition-based stats.
 Identities = 68/163 (41%), Positives = 93/163 (57%), Gaps = 5/163 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           +++IAA A + VIG  N +PW LP DLA F+  T   PVIMGR TWES+    RPLPGR+
Sbjct: 3   LAIIAACARNGVIGRNNDLPWRLPEDLAHFRSTTGGWPVIMGRLTWESLPARFRPLPGRR 62

Query: 59  NIILSSQ--PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           NII+S     G    V  V S++ A+          VIGG R+YE  LP A +L+LT ID
Sbjct: 63  NIIVSRGGVRGVPKGVDVVASLEAALELVQAERRAFVIGGARLYEAALPLADELFLTEID 122

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + EGD +FP+++   +         A+A N+ +Y F    R+
Sbjct: 123 EDFEGDVYFPEFDRSAFVEHHRMRRQAEAPNTFTYSFAHYRRK 165


>UniRef50_Q1QUE0 Dihydrofolate reductase n=12 Tax=Bacteria RepID=Q1QUE0_CHRSD
          Length = 195

 Score =  201 bits (511), Expect = 8e-51,   Method: Composition-based stats.
 Identities = 65/167 (38%), Positives = 96/167 (57%), Gaps = 10/167 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+L+AA++ +RVIG++N +PW+LP DL +FK  T++KP++MGR T+ESIGRPLPGR NI+
Sbjct: 19  IALVAAMSRNRVIGVDNKLPWHLPEDLKFFKAVTMSKPLVMGRKTFESIGRPLPGRLNIV 78

Query: 62  LSSQPGT---DDRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKLYL 112
           ++   G     D +     +  A+             +I VIGGG ++ + LP A +LYL
Sbjct: 79  VTRDRGYAQDHDGIRVCHDLASALDMADGQAIIDGVEDICVIGGGEIFAEALPCATRLYL 138

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T +D EVEGD  FP ++  +W+                Y F    RR
Sbjct: 139 TEVDIEVEGDAWFPAFDAREWQETQRVPGQGGEGKP-EYAFVHYTRR 184


>UniRef50_C9RIZ1 Dihydrofolate reductase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RIZ1_FIBSS
          Length = 163

 Score =  200 bits (510), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 60/162 (37%), Positives = 87/162 (53%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS I A++ + VIG +  +PW+L ADL  FK  T    +I+GR  ++ IGRPLP R N 
Sbjct: 2   LISAIVAVSENNVIGRDGHLPWHLSADLKRFKAITTGHAIILGRKNYDDIGRPLPNRTNY 61

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +L+              S+ EAI A       E  +IGG  VY + +P  +KLYLT + +
Sbjct: 62  VLTRNKDFQAPGCIVCSSLGEAIEAARAAGETECFIIGGAAVYREAMPLVEKLYLTRVLS 121

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            VEGD  FP++  D ++   +E   AD +N     FEI  R+
Sbjct: 122 HVEGDVFFPEWN-DKFQKESAESFPADEKNDFPTTFEIWVRK 162


>UniRef50_A1AXR7 Dihydrofolate reductase n=6 Tax=Proteobacteria RepID=A1AXR7_RUTMC
          Length = 163

 Score =  200 bits (509), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 62/158 (39%), Positives = 102/158 (64%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A+  +++IG  NA+PW LPADLA+FK+ T+ K V+MGR T++SIGRPL  R+NII
Sbjct: 3   LSIIVAMDDNQLIGKNNALPWYLPADLAYFKKTTIGKAVLMGRKTYDSIGRPLSNRRNII 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S       D    V S++ A+       E+M++GG   YEQ + K  ++Y+T ++ + +
Sbjct: 63  VSRNTKLKVDGCEVVGSINVALNLVNGANELMIMGGVSFYEQMIDKVDRIYITEVNGKFD 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT+FP+++   +  +  E H  D +N H++ F IL++
Sbjct: 123 GDTYFPEFDRTKFSELSRESHQPDEKNLHAHNFVILQK 160


>UniRef50_Q1CZU3 Dihydrofolate reductase n=1 Tax=Myxococcus xanthus DK 1622
           RepID=Q1CZU3_MYXXD
          Length = 159

 Score =  200 bits (509), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 66/160 (41%), Positives = 89/160 (55%), Gaps = 6/160 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S I A+A +RVIG  N +PW LPADLA FKR T+   ++MGR T+ESIGRPLPGR  I+
Sbjct: 3   LSAIVAMAANRVIGAGNQLPWRLPADLARFKRITMGHTLVMGRKTYESIGRPLPGRTFIV 62

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++ Q       V    SVDEA++        E+ + GG  +Y Q + + Q++YLTHI   
Sbjct: 63  VTRQRDFAPPGVQVAHSVDEALSLAKASGDSEVFIAGGADLYAQTMDRVQRIYLTHIARN 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             GDT FPD +   W  V  + H         + F   ER
Sbjct: 123 FPGDTWFPDVDLSGWTCVEEQAHPDAE---PPHTFLTYER 159


>UniRef50_Q3K556 Dihydrofolate reductase n=8 Tax=Bacteria RepID=Q3K556_PSEPF
          Length = 170

 Score =  199 bits (508), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 69/164 (42%), Positives = 104/164 (63%), Gaps = 8/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLIAAL  +RVIG++N+MPW+LP D  +FK  TL KP+IMGR TW+S+GRPLPGR NI+
Sbjct: 7   LSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNIV 66

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S Q G   +      S++ A+    +        E+M+IGG ++Y Q L +A +LYLT 
Sbjct: 67  VSRQAGLVLEGAEVYPSLEAAVVRAEEWAKDQGVDELMLIGGAQLYAQGLAQADRLYLTR 126

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +    EGD  FP+++ + W+ V +  + A   +  +Y FE+ E+
Sbjct: 127 VALSPEGDAWFPEFDLNQWKLVSNVPNPA-EGDKPAYNFEVWEK 169


>UniRef50_A5EUV9 Dihydrofolate reductase n=1 Tax=Dichelobacter nodosus VCS1703A
           RepID=A5EUV9_DICNV
          Length = 164

 Score =  199 bits (508), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 63/159 (39%), Positives = 92/159 (57%), Gaps = 1/159 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I LIAA  ++RVIG +  MPW+LP DL  FK+ T    +IMGR T++S+ +PLP RKNI+
Sbjct: 6   IHLIAAQTLNRVIGKDGGMPWHLPRDLQHFKQRTSGHTIIMGRKTFQSLKKPLPNRKNIV 65

Query: 62  LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S         V    ++ EA+A C +  ++ +IGGG +Y   + +A  L +T I  E+ 
Sbjct: 66  ISHSGQPLHADVAVFPAISEALAFCCNDEKVFIIGGGSLYAATIDEADFLTITWIHTELL 125

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FP   P DW+        ADA+N+ +  F   +RR
Sbjct: 126 GDTFFPPIRPQDWQETHRSHFAADAKNAFALDFVDYQRR 164


>UniRef50_Q67JQ2 Dihydrofolate reductase n=1 Tax=Symbiobacterium thermophilum
           RepID=Q67JQ2_SYMTH
          Length = 165

 Score =  199 bits (508), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 66/153 (43%), Positives = 87/153 (56%), Gaps = 4/153 (2%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67
           +  +R IG E  +PW LPA++  F+R T+ K V+MGR T+ESIG PL GR NI+L+  PG
Sbjct: 1   MGRNRAIGREGRLPWRLPAEMRHFRRTTMGKAVVMGRRTYESIGGPLKGRTNIVLTRDPG 60

Query: 68  T-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126
                     SV E +    D   + VIGG  VY QFLP A ++ LT ID + EGD  FP
Sbjct: 61  FRAPGCEVRHSVAELLQ---DRRPLYVIGGAEVYRQFLPHADEMILTRIDHDFEGDAFFP 117

Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +  D+WE V S  H  D +N + +  E   RR
Sbjct: 118 AWSEDEWELVGSTPHPRDEENPYDFVVEHYRRR 150


>UniRef50_C7PKU6 Dihydrofolate reductase n=1 Tax=Chitinophaga pinensis DSM 2588
           RepID=C7PKU6_CHIPD
          Length = 164

 Score =  199 bits (507), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 60/160 (37%), Positives = 102/160 (63%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A + + VIG+ N +PW+LP D+ +FK  T+ KP++MGR ++E +GR LPGR NI+
Sbjct: 3   LSIIVAASENNVIGINNHLPWHLPVDMKYFKDTTMGKPIVMGRKSFEELGRVLPGRPNIM 62

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++ Q     + +  V S++  I         EI V GGG +++  L    ++YLT + A 
Sbjct: 63  ITRQKDYTAEGLHIVPSLEAGIEKAKTFGTEEIFVTGGGEIFKMALSIVDRVYLTRVHAT 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           V+GDT+FP+++P  W+ V +E H+ D +++H+  F++ ER
Sbjct: 123 VQGDTYFPEFDPRGWKLVKNERHEKDEKHAHALTFQVWER 162


>UniRef50_C0YTZ2 Possible dihydrofolate reductase type I involved in trimethoprim
           resistance n=1 Tax=Chryseobacterium gleum ATCC 35910
           RepID=C0YTZ2_9FLAO
          Length = 165

 Score =  198 bits (505), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 61/160 (38%), Positives = 92/160 (57%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M +++ A+     IG EN + W+LP DL  FK  T   PVIMGR T+ESIG+ LP R NI
Sbjct: 1   MTTIVVAMGEKNEIGFENQLLWHLPKDLKHFKEITSGHPVIMGRKTYESIGKALPNRTNI 60

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++S +    ++ +  V S+ EA+        E+ VIGGG +YEQ +    +L +T + A+
Sbjct: 61  VVSRKKDWFEEGILIVGSIKEALKFAKKIDEEVFVIGGGNIYEQTMDVVDRLEVTLVKAD 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +E DT FP  +P  W+      H+ D +N + +CF+  ER
Sbjct: 121 LEADTFFPKIDPKIWKMTNEICHEKDEKNGYDFCFQTFER 160


>UniRef50_C7RLL7 Dihydrofolate reductase n=1 Tax=Candidatus Accumulibacter
           phosphatis clade IIA str. UW-1 RepID=C7RLL7_9PROT
          Length = 169

 Score =  198 bits (504), Expect = 6e-50,   Method: Composition-based stats.
 Identities = 62/169 (36%), Positives = 88/169 (52%), Gaps = 10/169 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           MISLIAA+A +  IG    + W LP D+ +F+  T  K VIMGR TWES+    RPLP R
Sbjct: 1   MISLIAAVARNGAIGRNQQLLWRLPEDMRYFRETTSGKTVIMGRKTWESLPPAYRPLPNR 60

Query: 58  KNIILSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +NI+LS  P           S+++A+   G   E+ +IGG  +Y Q +P A +LY+T + 
Sbjct: 61  RNIVLSRNPAYLPRGGDLACSIEDALRLAGGAAEVFIIGGEELYRQTMPLATRLYITEVA 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSE------FHDADAQNSHSYCFEILERR 159
            E  GD  FPD    +W  +            A    + ++ F + ERR
Sbjct: 121 EESPGDAFFPDVASGEWREISRRVGRSRAAGSALRDQAPAFDFVVYERR 169


>UniRef50_Q15PF1 Dihydrofolate reductase n=18 Tax=Gammaproteobacteria
           RepID=Q15PF1_PSEA6
          Length = 171

 Score =  198 bits (503), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 81/168 (48%), Positives = 107/168 (63%), Gaps = 11/168 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+++AA+A  RVIG+ N MPW++PADL  FKR TL KP++MGR T+ESIGR LPGR NI+
Sbjct: 4   IAMVAAMANQRVIGLNNQMPWHMPADLKHFKRITLGKPIVMGRKTYESIGRALPGRLNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAAC----------GDVPEIMVIGGGRVYEQFLPKAQKL 110
           ++S         + V S ++AIA                E+MVIGGG VY+ FLP A +L
Sbjct: 64  ITSDQNYQLADASIVHSCEQAIAVATSHMQNDGMPEHDQEVMVIGGGTVYQHFLPHANRL 123

Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           YLT ID +  GDT+FP+Y    W+ + SE +D D +N HSY F  L R
Sbjct: 124 YLTFIDLDTPGDTYFPNYSDGAWQEIESESNDPDEKNPHSYRFVTLAR 171


>UniRef50_C9BJS9 Dihydrofolate reductase n=13 Tax=Enterococcus RepID=C9BJS9_ENTFC
          Length = 175

 Score =  197 bits (502), Expect = 9e-50,   Method: Composition-based stats.
 Identities = 56/161 (34%), Positives = 89/161 (55%), Gaps = 3/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           M++ I A   + +IG E+ +PW LP DL +FK+ T    ++MGR T+E +G RPLP R+ 
Sbjct: 1   MLAAIWAQDENGLIGKEDRLPWRLPNDLKFFKQMTEANTLVMGRKTFEGMGSRPLPNRQT 60

Query: 60  IILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVI-GGGRVYEQFLPKAQKLYLTHIDA 117
           I+L+       + V  + SV++ +A   +   I  I GG  VY++FLP    LY T I  
Sbjct: 61  IVLTRDSSYKAEGVHVMHSVEDVLALEKETDGIFFIAGGSAVYQEFLPFCTILYRTVIHH 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             +GD +FP  +  DW  + +   + D +N + + FE  +R
Sbjct: 121 VFDGDAYFPPVDWSDWSLINTSQGEMDEKNRYPHQFETYQR 161


>UniRef50_Q5WDS2 Dihydrofolate reductase n=3 Tax=Bacillus RepID=Q5WDS2_BACSK
          Length = 162

 Score =  197 bits (502), Expect = 9e-50,   Method: Composition-based stats.
 Identities = 51/160 (31%), Positives = 80/160 (50%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI  + A      IG +N +PW+LPADL  FKR T  + ++MGR T++S+G PLP RKN+
Sbjct: 1   MIVFVYARDAHYGIGKDNGLPWHLPADLRHFKRTTTGQTIVMGRKTFDSMGGPLPNRKNV 60

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L+       +    + S+D+ +        I VIGG  ++        K  +T ID + 
Sbjct: 61  VLTRSRSFQAEGAEVIHSLDDVLQLSKQ-EAIYVIGGAEIFALLWDICDKHIVTVIDEKF 119

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E DT  P     +WE V +     D +N + + +    R+
Sbjct: 120 EADTFVPPLSEQEWELVETVPGPIDEKNRYPHEYRTYVRK 159


>UniRef50_Q5R038 Dihydrofolate reductase n=3 Tax=Alteromonadales RepID=Q5R038_IDILO
          Length = 166

 Score =  197 bits (502), Expect = 9e-50,   Method: Composition-based stats.
 Identities = 85/162 (52%), Positives = 117/162 (72%), Gaps = 5/162 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISL+ A+A +RVIG +N MPW+LP +L +FK+ TL KP++MGR T+ESIGRPLPGRKNI+
Sbjct: 3   ISLVVAMADNRVIGKDNKMPWHLPDELQYFKKITLGKPIVMGRRTFESIGRPLPGRKNIV 62

Query: 62  LSSQPGTDDR----VTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           LS +    +     V WV  V +AIAA G V E+M+IGGG++YE+FLP A +LY+T I+ 
Sbjct: 63  LSRRTDRSENQDSQVVWVSGVQQAIAAAGPVEELMIIGGGKIYEKFLPLADRLYVTKIEL 122

Query: 118 EVEGDTHFPDY-EPDDWESVFSEFHDADAQNSHSYCFEILER 158
            VEGDT+FPDY +  DW+ +  +   AD +NSH++   I +R
Sbjct: 123 NVEGDTYFPDYHQVADWQEIERQNFAADERNSHNFSTLIFDR 164


>UniRef50_C1XJD1 Dihydrofolate reductase n=1 Tax=Meiothermus ruber DSM 1279
           RepID=C1XJD1_MEIRU
          Length = 171

 Score =  197 bits (501), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 62/159 (38%), Positives = 94/159 (59%), Gaps = 5/159 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+ + A+  +R IG    +PW+LP DL  F+  TL K V+MGR T+ESIGRPLP R+N++
Sbjct: 5   IAFVVAMDQNRAIGRAGTLPWHLPDDLKRFRALTLGKTVLMGRKTFESIGRPLPKRRNVV 64

Query: 62  LSSQP-GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119
           L+  P    + V  V ++++A+       E+MVIGGG +Y  FLP    L+LT ++  V 
Sbjct: 65  LTRDPAFAAEGVEVVHTLEDALKL---DDELMVIGGGEIYTLFLPLVTHLHLTLVETVVP 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + D  FP + P  W   + E H AD ++  ++ +  LER
Sbjct: 122 DADAFFPPWNPTGWRETYREHHPADERHPWAFTYLDLER 160


>UniRef50_Q47IJ5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=Q47IJ5_DECAR
          Length = 163

 Score =  197 bits (501), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 57/162 (35%), Positives = 86/162 (53%), Gaps = 6/162 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           I LIAA+A +RVIG +N + WNLP D+A FK  T  + V+MGR TWES+    RPLPGR+
Sbjct: 4   IILIAAVAKNRVIGKDNTLIWNLPEDMAHFKALTAGQTVVMGRKTWESLPPRFRPLPGRR 63

Query: 59  NIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           N+++S Q            S++ A+        + +IGG ++Y+Q +  A +L +T +D 
Sbjct: 64  NVVISRQADYAAPGAEVANSLENALQLASTAESVFIIGGEQIYKQAMAVADRLEITDVDL 123

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E  GD  FP+    DW         + +     + F    R+
Sbjct: 124 EPAGDAWFPEIAATDWSVTQKNTPPSQS--GTGFSFVTYRRK 163


>UniRef50_A5GBA2 Dihydrofolate reductase n=2 Tax=Geobacter RepID=A5GBA2_GEOUR
          Length = 163

 Score =  197 bits (501), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 69/160 (43%), Positives = 98/160 (61%), Gaps = 6/160 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAA+A +RVIG  NA+PW++PAD   F+  TL  PVIMGR T+ES+  PLPGRKNI
Sbjct: 2   VISLIAAMAENRVIGRNNAIPWDIPADRKRFRALTLGHPVIMGRKTFESLAGPLPGRKNI 61

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++ Q     +       +  A+A  G+  EI + GGG +Y Q LP A ++YLT I +  
Sbjct: 62  IITRQMDYRAEGCFIAHDLASALAMAGETDEIFICGGGEIYRQALPIADRIYLTIIHSRF 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP+  P+ +  V  E      +N+  Y F + ++R
Sbjct: 122 DGDTRFPEI-PERFVEVGRETV----ENAIPYSFVLYDKR 156


>UniRef50_A7HVX5 Dihydrofolate reductase n=13 Tax=Proteobacteria RepID=A7HVX5_PARL1
          Length = 169

 Score =  197 bits (501), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 67/165 (40%), Positives = 97/165 (58%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           +S + A+A + VIG +N++PW L  D+A+FKR T+ KPVIMGR TWES+ R PLPGR NI
Sbjct: 3   VSYVVAIADNGVIGRDNSLPWRLSGDMAFFKRITMGKPVIMGRKTWESLPRKPLPGRPNI 62

Query: 61  ILSSQPGTD-DRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++     + +      S  EA+      A+     E+MVIGG ++Y +    A +LY+T
Sbjct: 63  VVTRDAQYEAEGAEIAASAVEALRRGRELASASGADEVMVIGGAQLYAEMFDDATRLYIT 122

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            + A  EGD  FP ++   W  V  E H A  ++S  Y F +LER
Sbjct: 123 EVHAAPEGDVSFPAFDAAHWREVSRERHKAGEKDSADYSFVVLER 167


>UniRef50_A1VQZ7 Dihydrofolate reductase n=9 Tax=Bacteria RepID=A1VQZ7_POLNA
          Length = 166

 Score =  196 bits (500), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 62/161 (38%), Positives = 89/161 (55%), Gaps = 7/161 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           I+LI A A + VIG  NAMPW+LP DLA FKR T   PVIMGR TW+S+    RPLPGR 
Sbjct: 6   INLIYARAANGVIGRNNAMPWHLPEDLAHFKRLTQGWPVIMGRKTWDSLPPRFRPLPGRT 65

Query: 59  NIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           N++++ QP           S+ +A+A C    E+ VIGG ++Y    P A ++ +T I  
Sbjct: 66  NLVITRQPDWQAPGALPAASLADALAQCSQSEEVWVIGGAQIYAHAEPLADRIEVTEIAQ 125

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + +GD   P    ++W+    E H +   +   + F   E+
Sbjct: 126 DFDGDAFAPPLG-EEWQETAREAHVSS--HGLPFSFVTFEK 163


>UniRef50_D0J2N2 Dihydrofolate reductase region n=3 Tax=Bacteria RepID=D0J2N2_COMTE
          Length = 167

 Score =  196 bits (500), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 66/167 (39%), Positives = 91/167 (54%), Gaps = 12/167 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           I LI A A + VIG +N MPW+LP D+A FK  T    VIMGR TW+S+    RPLPGR 
Sbjct: 3   IQLIYARAANGVIGKDNTMPWHLPEDMAHFKELTRGCAVIMGRKTWDSLPPRFRPLPGRS 62

Query: 59  NIILSSQPGTD-----DRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYL 112
           NI+++ Q         D+V    S+ EA+    +   ++ VIGG ++Y Q LP A  + +
Sbjct: 63  NIVVTRQADWQAEPASDQVLRAASLSEALELGRNLSQDVWVIGGAQIYAQALPLADAVEV 122

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T I  + EGD   P+   + W++V    H   + N   YCF   ERR
Sbjct: 123 TEIGRDFEGDAFAPELG-EQWQAVSRSEH--VSANGLPYCFVRFERR 166


>UniRef50_UPI0000E87D66 dihydrofolate reductase n=1 Tax=Methylophilales bacterium HTCC2181
           RepID=UPI0000E87D66
          Length = 161

 Score =  196 bits (500), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 61/159 (38%), Positives = 96/159 (60%), Gaps = 3/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A++ + VIG+ N +PW++P DL  FK  T+  P++MGR T++SIGRPLPGRKNI+
Sbjct: 4   ISIIVAMSNNNVIGINNTLPWHIPQDLKRFKSLTMGNPIVMGRKTFDSIGRPLPGRKNIV 63

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++    +  + V  V S++  +A   D   + VIGG ++Y+ FL  A  LY+T +D++V 
Sbjct: 64  ITRNEDSIIEGVEIVNSINSLLALIKDEEHVFVIGGEQIYKIFLDHATHLYVTEVDSDVA 123

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GD HFP      W+ V  E     +++   + F    R+
Sbjct: 124 GDAHFPKLSTSQWKEVGREK--LVSKDDLHFSFVDYIRQ 160


>UniRef50_A2U3M8 Dihydrofolate reductase n=2 Tax=Polaribacter RepID=A2U3M8_9FLAO
          Length = 164

 Score =  196 bits (499), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 60/161 (37%), Positives = 90/161 (55%), Gaps = 3/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI++IAA+A +  +G  N + W+LPADL  FK+ T    ++MGR+T+ESIGRPLP R  I
Sbjct: 1   MITIIAAIAKNNALGKNNDLIWHLPADLKRFKKVTTGHHILMGRNTFESIGRPLPNRITI 60

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL--PKAQKLYLTHIDA 117
           I++       +      SV++A+    D  +I +IGG +VYE  +    A  L +T +  
Sbjct: 61  IITKNEEYVQEGCLIANSVEQALEMAHDDDQIFIIGGAQVYEYAMKHDFADALDITLVHH 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E E D +FP+ +P  W  V  E   AD +N   Y F   ++
Sbjct: 121 EFEADVYFPEIDPTVWRRVEREDFIADEKNKFDYSFIRYKK 161


>UniRef50_C6CYL9 Dihydrofolate reductase n=1 Tax=Paenibacillus sp. JDR-2
           RepID=C6CYL9_PAESJ
          Length = 163

 Score =  196 bits (499), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 69/160 (43%), Positives = 102/160 (63%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I++IAA+   R IG+ N +PW LPA++A+F R+T  K V+MGR T+ES+ +PL  R N++
Sbjct: 3   ITMIAAMDRGRTIGIGNKLPWRLPAEMAYFTRHTTGKAVVMGRKTFESLPKPLKDRTNVV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++ QP    +    V SV EAI   G+  E+MVIGG  +Y QFLP A K+ LT +D  +E
Sbjct: 63  ITRQPEYAKEGCEVVHSVQEAIDRYGEG-ELMVIGGADIYAQFLPFADKIRLTEVDTNIE 121

Query: 121 -GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GD  FP +   +WE V +E  ++D +N+ S+ F+   RR
Sbjct: 122 GGDAFFPTFNEGEWERVDAEKVESDERNAFSFTFQTFARR 161


>UniRef50_Q04F50 Dihydrofolate reductase n=2 Tax=Oenococcus oeni RepID=Q04F50_OENOB
          Length = 170

 Score =  196 bits (498), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 64/164 (39%), Positives = 94/164 (57%), Gaps = 5/164 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MI+ I A + + VIG  N +PW+LP DL +F++ T NK V+MGR T+ES G + LP R N
Sbjct: 1   MITSIWAQSKNNVIGRNNHLPWSLPDDLKFFRQETKNKAVVMGRKTYESFGSKALPKRLN 60

Query: 60  IILSSQPGT---DDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHI 115
           IIL+S       D  V  V S  EA+    +    + VIGG  VYE F+  A +L +T +
Sbjct: 61  IILTSNMDFKSNDPEVKIVHSPIEAVNTAKEQHLPLYVIGGASVYESFMNMADRLLITLV 120

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           DA ++GDT  P++    +  V    H  D ++++S+ F   ER+
Sbjct: 121 DANIKGDTFAPNFSEKSFSLVSQCHHAQDKKHAYSFDFLTYERK 164


>UniRef50_Q5X875 Dihydrofolate reductase FolA n=6 Tax=Legionella RepID=Q5X875_LEGPA
          Length = 163

 Score =  195 bits (496), Expect = 4e-49,   Method: Composition-based stats.
 Identities = 64/158 (40%), Positives = 89/158 (56%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAA+     +G+ N +   LPADL  FK  T+ KP+IMGR T+ESIG+PLPGR NI
Sbjct: 3   LISLIAAIDETGGLGINNQLLCYLPADLQHFKSITMGKPIIMGRKTYESIGKPLPGRLNI 62

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++S    +   V  V S+ +AI    D  E+M+IGG ++Y Q +  A +LY+T I  +  
Sbjct: 63  VISQSIQSIPGVVVVDSLGQAIKETADASEVMIIGGAKIYSQAISIANRLYITRIHHQFM 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            D  FP      W     E+   D +N +   F I ER
Sbjct: 123 ADVFFPKINELVWSCRSKEYRQHDNKNQYDMTFCIYER 160


>UniRef50_A6UB22 Dihydrofolate reductase n=18 Tax=Alphaproteobacteria
           RepID=A6UB22_SINMW
          Length = 187

 Score =  194 bits (495), Expect = 5e-49,   Method: Composition-based stats.
 Identities = 67/165 (40%), Positives = 96/165 (58%), Gaps = 7/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I ++ A+A++ VIG E  +PW LP DL  FK  T+ KPVIMGR TW +IGRPLPGR NI+
Sbjct: 14  IVIVVAVALNGVIGREGDLPWRLPTDLKRFKAQTIGKPVIMGRKTWAAIGRPLPGRPNIV 73

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++     +        S++ A+A   +        EI VIGGG +Y Q +  A  L++T 
Sbjct: 74  VTRNRAFEAPGAEVAPSLEAALAVARERAAAIGADEICVIGGGEIYRQSIGMADVLHVTE 133

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + AEV+GDT FP+ +P  +E V  E   +  ++SH+  F    RR
Sbjct: 134 VQAEVDGDTRFPEIDPAVFEKVLEEDLQSGEKDSHAMHFVTWRRR 178


>UniRef50_D1BNV5 Dihydrofolate reductase region n=4 Tax=Veillonellaceae
           RepID=D1BNV5_VEIPT
          Length = 164

 Score =  194 bits (495), Expect = 6e-49,   Method: Composition-based stats.
 Identities = 54/161 (33%), Positives = 86/161 (53%), Gaps = 2/161 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M++LI A+A +RVIG +N + W+LP DL +FK  T    +IMGR T+ES+   LP R++ 
Sbjct: 1   MLALIVAVAHNRVIGKDNTLIWHLPNDLKFFKEKTTGHVIIMGRKTFESLPFLLPNREHW 60

Query: 61  ILSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +++        + V    + + A  A   +    VIGG +VYE FLP    +Y+T +D E
Sbjct: 61  VITRDKGFDAPEGVKIFHNPEAAAEAARALDAAYVIGGAQVYEAFLPYVDTMYITEVDHE 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +GD  FP++  D +          D +N + + F    R+
Sbjct: 121 FDGDAFFPEFSEDAFTIESVVDGIVDEKNQYPHRFVTYRRK 161


>UniRef50_A4IUE2 Dihydrofolate reductase n=1 Tax=Yersinia ruckeri RepID=A4IUE2_YERRU
          Length = 191

 Score =  194 bits (495), Expect = 6e-49,   Method: Composition-based stats.
 Identities = 68/162 (41%), Positives = 101/162 (62%), Gaps = 5/162 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLI A+A +  IG +NA+PW+LP DL + K++T+ KP++MGR T++SIGRPLPGR N+
Sbjct: 27  IISLILAMADNGTIGDKNALPWHLPNDLQFLKKSTMGKPIVMGRKTYQSIGRPLPGRTNV 86

Query: 61  ILSSQPGTD--DRVTWVKSVDEAIAACG---DVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           ++S     +          +  AIAA     +V EIM++GG ++Y   LP   +LYLTH+
Sbjct: 87  VISRSLEKEALPGCLIYSDLSVAIAALKKEPEVEEIMIMGGAQIYRAALPMMDRLYLTHV 146

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
            A +EGDT  P ++      +F E H  D +N + Y FEI +
Sbjct: 147 HANIEGDTQMPPFDFSHATLIFEEKHFKDEKNRYDYTFEIWD 188


>UniRef50_A5CVJ7 Dihydrofolate reductase n=1 Tax=Candidatus Vesicomyosocius okutanii
           HA RepID=A5CVJ7_VESOH
          Length = 163

 Score =  194 bits (493), Expect = 9e-49,   Method: Composition-based stats.
 Identities = 60/158 (37%), Positives = 100/158 (63%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A+  + +IG +N++PW LPADLA+FK+ T+ K ++MGR T +SIGR LP R+NII
Sbjct: 3   LSIIVAMDDNYLIGKDNSLPWYLPADLAYFKKITIGKTILMGRKTHDSIGRSLPNRRNII 62

Query: 62  LSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S       D    V S+D A++   +  E+M++GG   Y+Q + K  +LY+T +    +
Sbjct: 63  VSKNTKFKADNCEVVSSIDVALSLANNDNELMIVGGSSFYDQIIDKVDRLYITEVKGMFD 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD +FP+++   +  +  E H  D +N ++Y F +L+R
Sbjct: 123 GDAYFPEFDRTKFIELSRESHKPDEKNFYTYNFIVLQR 160


>UniRef50_Q21NW4 Dihydrofolate reductase n=3 Tax=Bacteria RepID=Q21NW4_SACD2
          Length = 171

 Score =  194 bits (493), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 61/169 (36%), Positives = 98/169 (57%), Gaps = 11/169 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + ++ A A + VIG+ N +PW + ADL  FK+ T+  P+IMGR T++SIG+PLPGR  I+
Sbjct: 3   LVIVVAAAQNGVIGINNTLPWRISADLQHFKQVTIGHPIIMGRKTYDSIGKPLPGRTTIV 62

Query: 62  LSSQPG-----TDDRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKL 110
           ++ Q        +D+V    S++ A+     +       E M++GG ++Y Q L +  K+
Sbjct: 63  VTRQADWQAEGYEDQVKVAYSLEGAMELAEQIAAQMGVAEAMLVGGAQLYRQALERVSKV 122

Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +LT + AE+EGD  FP+ + + W  V    + AD +N + Y F  L RR
Sbjct: 123 HLTRVHAEIEGDAWFPELDGNIWAEVQCVRYKADEKNEYDYSFVELHRR 171


>UniRef50_C5CTW3 Dihydrofolate reductase n=1 Tax=Variovorax paradoxus S110
           RepID=C5CTW3_VARPS
          Length = 177

 Score =  193 bits (491), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 62/163 (38%), Positives = 93/163 (57%), Gaps = 7/163 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           I LI A A + VIG +  +PW+LP D+  FK+ T   PV+MGR TW+S+    RPLPGR+
Sbjct: 10  IHLIFARAANGVIGAKGTIPWHLPEDMVHFKQQTAGAPVVMGRKTWDSLPPRFRPLPGRR 69

Query: 59  NIILSSQPGT-DDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           NI+++ Q     +    V S+ EA+A C +   P++ +IGG ++Y +  P AQ++ +T +
Sbjct: 70  NIVVTRQDDWKAEGAWRVGSLQEALALCEESQVPDVWIIGGAQIYAEAEPLAQQVVVTEL 129

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             + EGD H P+  P  W     E H   A+   +Y F   ER
Sbjct: 130 AHDYEGDAHAPELSPSAWRETKREAH-VSAKEGLNYSFVTYER 171


>UniRef50_UPI0001698640 dihydrofolate reductase n=1 Tax=Endoriftia persephone
           'Hot96_1+Hot96_2' RepID=UPI0001698640
          Length = 158

 Score =  193 bits (491), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 71/149 (47%), Positives = 97/149 (65%), Gaps = 1/149 (0%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67
           +A +RVIG  N MPW+LPADL  FK  T+ KP++MGR TWES+   LP R +I+++  P 
Sbjct: 1   MARNRVIGRHNRMPWHLPADLRHFKALTIGKPIVMGRKTWESLPGLLPDRPHIVVTHNPS 60

Query: 68  T-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126
              +  T V S+DEAIAA G+V EIMV+GGG  Y + LP+  ++YLT +DAE EGDT FP
Sbjct: 61  YYAEGCTLVHSIDEAIAAAGEVEEIMVVGGGAFYAEILPRVGRIYLTLVDAEFEGDTLFP 120

Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEI 155
           D +  +W     E H AD ++++ Y    
Sbjct: 121 DLDMAEWLECSRERHPADEKHTYPYSLHR 149


>UniRef50_Q11US6 Dihydrofolate reductase n=1 Tax=Cytophaga hutchinsonii ATCC 33406
           RepID=Q11US6_CYTH3
          Length = 161

 Score =  193 bits (490), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 62/162 (38%), Positives = 86/162 (53%), Gaps = 5/162 (3%)

Query: 1   MI-SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKN 59
           MI S+I A + +R IG+ N +PW+LPADL  FK  T+   +IMGR T+ESIG PLPGR +
Sbjct: 1   MIRSIIVAQSENRAIGINNTLPWHLPADLKRFKAITMGHHMIMGRKTYESIGNPLPGRTS 60

Query: 60  IILSSQPGTD-DRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+++          T   S+ EA     +    E  VIGG  + ++ +    KLYLT I 
Sbjct: 61  IVVTRNKDLVFAGCTMAHSLAEAFEIAQNNNDSEAFVIGGAELIKEAINSCDKLYLTTIH 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              EGDT        DW+      H  D +N++SY F   E+
Sbjct: 121 QNFEGDTFLDAL-ASDWKETEHVVHAPDDKNAYSYSFITYEK 161


>UniRef50_D2QWB5 Dihydrofolate reductase n=1 Tax=Pirellula staleyi DSM 6068
           RepID=D2QWB5_9PLAN
          Length = 171

 Score =  193 bits (490), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 59/159 (37%), Positives = 93/159 (58%), Gaps = 3/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SLI A+  + +IG +  +PW + ADL  F+  T+   +IMGR TW+S+GR LPGR +I+
Sbjct: 11  LSLIVAMTREGLIGRDRDLPWKISADLKRFRSLTMGHTIIMGRTTWDSLGRALPGRTSIV 70

Query: 62  LSSQPG--TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           L+ +      + V    S+DEAIA      E  +IGGG +Y Q + + Q+LY+T ++A +
Sbjct: 71  LTRKADLVLPEGVLRAGSLDEAIALAAGDSEPFIIGGGEIYRQAMDRVQQLYVTWVEANI 130

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGDT FP ++P  +  +    H A    + ++ F   ER
Sbjct: 131 EGDTWFPAWDPSKFRLLEETSHPA-EGTTPAFTFTRYER 168


>UniRef50_Q54277 Dihydrofolate reductase n=84 Tax=Bacilli RepID=DYR_STAHA
          Length = 166

 Score =  193 bits (490), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 62/158 (39%), Positives = 87/158 (55%), Gaps = 1/158 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A+   RVIG +N +PW + +D  + K  T    +I+GR   +SIGR LP R+NII
Sbjct: 7   ISLIVAMDKKRVIGKDNDIPWRISSDWEYVKNTTKGHAIILGRKNLQSIGRALPDRRNII 66

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+     +        S++ A   C +  E+ + GG ++Y  FLP  +K+Y+T I  E E
Sbjct: 67  LTRDKNFNFKDCEIAHSIEAAFKLCENEEEVFIFGGEQIYVMFLPYVEKMYVTKIHHEFE 126

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GDT FP    DDW+ V  E    D +N + Y F I ER
Sbjct: 127 GDTFFPVVNFDDWKEVSVEKGIKDEKNPYDYYFHIYER 164


>UniRef50_C0XLT5 Dihydrofolate reductase n=3 Tax=Lactobacillus RepID=C0XLT5_LACHI
          Length = 162

 Score =  192 bits (489), Expect = 3e-48,   Method: Composition-based stats.
 Identities = 57/160 (35%), Positives = 84/160 (52%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS I A   + +IG    +PW+LP D+A+FK+ T+  P+I G  T+ S  RPLPGR+NI
Sbjct: 1   MISYIWAEDENGLIGASGNLPWHLPDDMAFFKKTTMGHPIISGARTFRSYNRPLPGRQNI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +LS      D V  + SV++              V GG  ++ Q L K  +LY T I  +
Sbjct: 61  VLSRHGDFPDGVLVISSVEQLCELVDKNPKENYFVTGGANLFGQLLDKVDRLYRTKIHHQ 120

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             GDT+ P+ +   +  V S     D +N + + FE+ ER
Sbjct: 121 FTGDTYMPEIKYAQFNQVTSIDGIVDERNRYPHTFEVFER 160


>UniRef50_Q5P234 Dihydrofolate reductase n=14 Tax=cellular organisms
           RepID=Q5P234_AZOSE
          Length = 167

 Score =  192 bits (489), Expect = 3e-48,   Method: Composition-based stats.
 Identities = 65/159 (40%), Positives = 92/159 (57%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + +IAA A +  IG +N +PW L +DLA FK  T+  PV+MGR TWES+GRPLP R+N++
Sbjct: 8   VIIIAATARNGAIGRDNQLPWRLKSDLARFKETTIGHPVLMGRKTWESLGRPLPARRNLV 67

Query: 62  LSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           ++                + A+ A GD   + VIGG  +Y Q L  A  L LT + A+V 
Sbjct: 68  VTRDRSYSATGAEVFPDPEAALEAAGD-ETVFVIGGAELYRQLLDSADALLLTEVHADVA 126

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GD +FP ++  D++ V  E HDADA N  S+ F    R+
Sbjct: 127 GDAYFPPFDRGDFDEVRREQHDADAHNEFSFDFVEYRRK 165


>UniRef50_B8KL97 Dihydrofolate reductase n=1 Tax=gamma proteobacterium NOR5-3
           RepID=B8KL97_9GAMM
          Length = 182

 Score =  192 bits (488), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 68/165 (41%), Positives = 98/165 (59%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+LI A A + VIG +NA+PW LP DLA FKR T+ KP++MGR T+ESIGRPLPGR NI+
Sbjct: 6   IALIVAAADNDVIGRDNALPWQLPGDLAHFKRTTMGKPILMGRLTYESIGRPLPGRTNIV 65

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +S  PG     V  V+S+++A+    D        E+M+IGG ++Y   LP A ++YLT 
Sbjct: 66  ISRDPGYSAAGVRSVQSLEKALELAKDIAVIDGSSELMIIGGAQIYALALPLASRIYLTR 125

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +  E  GD   P  +   W+    + + AD  +  ++ F    R+
Sbjct: 126 VHVEPAGDAFLPAIDWAHWKESGRQENPADG-SVPAHTFLEYTRQ 169


>UniRef50_Q9RR65 Dihydrofolate reductase n=2 Tax=Deinococcus RepID=Q9RR65_DEIRA
          Length = 180

 Score =  192 bits (488), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 64/160 (40%), Positives = 91/160 (56%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           I  IAA   +RVIG +  MPW+LPAD A F+  ++ KP IMGR  ++++ R PLP R NI
Sbjct: 17  IVAIAAQTENRVIGRDGGMPWHLPADFAHFRALSVGKPNIMGRKVFDTLRRKPLPERVNI 76

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L+       D      S +EA+   GD PEI +IGG  +Y  +  +  +L +T I AE+
Sbjct: 77  VLTRNENLKFDGCLIAHSPEEALQLAGDAPEIAIIGGEEIYRLYWDRLTRLEMTLIHAEL 136

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +GDT FP+  P +WE     F  AD +N +   F+   RR
Sbjct: 137 DGDTFFPEIGP-EWELAQETFRPADEKNRYDLTFQTWRRR 175


>UniRef50_A3N0P3 Dihydrofolate reductase n=6 Tax=Pasteurellaceae RepID=A3N0P3_ACTP2
          Length = 162

 Score =  191 bits (487), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 79/161 (49%), Positives = 106/161 (65%), Gaps = 4/161 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A  ++ VIG EN MPWNLP DLAWF++NTL KPVIMGR T+ESIGR LP R NII
Sbjct: 3   ISLIVARTLNHVIGKENQMPWNLPVDLAWFRQNTLGKPVIMGRKTYESIGRLLPKRPNII 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACG---DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LS      +     ++  +A        +  EIMVIGGG +++Q +P+A +LYLT I AE
Sbjct: 63  LSRSGFCVEGAYTAQNFAQAAELAETFANTDEIMVIGGGELFKQTIPQADRLYLTEIQAE 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +EGDT F +++  +W  V  ++ + D QN++   F ILER+
Sbjct: 123 IEGDTLF-EFDESNWTLVEEKWSEIDEQNAYRCRFMILERK 162


>UniRef50_Q2K6G9 Dihydrofolate reductase protein n=3 Tax=Rhizobiales
           RepID=Q2K6G9_RHIEC
          Length = 172

 Score =  191 bits (487), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 65/164 (39%), Positives = 100/164 (60%), Gaps = 7/164 (4%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           ++IAA+A +  IG E  MPW L +DL  FK  TL KPV+MGR T++SIG+PLPGR N+++
Sbjct: 7   TIIAAVARNGTIGREGDMPWRLSSDLKRFKTLTLGKPVVMGRRTYDSIGKPLPGRPNVVI 66

Query: 63  SSQPGTDD-RVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           S Q   D   ++   S+ EA+ A           EI +IGGG++Y Q +  A ++Y+TH+
Sbjct: 67  SRQAAIDHSDISMAHSLAEALEAAERLALQTGAGEICIIGGGQIYAQAIDLADRMYITHV 126

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +A+++GD  FP  +P  W++       A  ++S+   F + ERR
Sbjct: 127 EADLDGDAFFPAIDPGTWQAGEVVAVPAGERDSYPTRFVVYERR 170


>UniRef50_C3JBM5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=C3JBM5_9PORP
          Length = 170

 Score =  191 bits (487), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 51/159 (32%), Positives = 88/159 (55%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           +S+I A+A +  IG +N + W+LP DL  FK  T    +IMG++T+ S+    LP R+NI
Sbjct: 3   LSIIVAVAANNAIGKDNDLLWHLPGDLKRFKETTTGHAIIMGKNTFHSLPNGALPNRRNI 62

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119
           ++SS     D V    ++  A+ A     E+ +IGG ++Y   LP A K+Y + ++    
Sbjct: 63  VVSSTLVPPDGVECYSTLQAALEAVAGEEEVFIIGGAQLYAASLPLADKIYFSRVEKGFP 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E DT+FP+++  +W   +   +  D +N ++    I +R
Sbjct: 123 EADTYFPEFDLTEWTPSYCTLYPEDERNEYAVTLTIYQR 161


>UniRef50_P04174 Dihydrofolate reductase n=33 Tax=Neisseriaceae RepID=DYR_NEIGO
          Length = 162

 Score =  191 bits (487), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 63/157 (40%), Positives = 90/157 (57%), Gaps = 3/157 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           I++IAA A +  IG  NAMPW++P D A+FK  TL KPVIMGR TWES+  +PLPGR+NI
Sbjct: 4   ITIIAACAENLCIGAGNAMPWHIPEDFAFFKVYTLGKPVIMGRKTWESLPVKPLPGRRNI 63

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S Q          V S++ A+A C    E +++GG ++Y Q +P A  L +T +D  V
Sbjct: 64  VISRQADYCAAGAETVASLEVALALCAGAEEAVIMGGAQIYGQAMPLATDLRITEVDLSV 123

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
           EGD  FP+ +   W           ++   +Y F   
Sbjct: 124 EGDAFFPEIDRTHWREAERTERRVSSK-GVAYTFVHY 159


>UniRef50_A1WMP6 Dihydrofolate reductase n=2 Tax=Proteobacteria RepID=A1WMP6_VEREI
          Length = 162

 Score =  191 bits (486), Expect = 7e-48,   Method: Composition-based stats.
 Identities = 56/161 (34%), Positives = 85/161 (52%), Gaps = 7/161 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           + LI A A + VIG +  +PW+LP D+A F++ T    VIMGR TW+S+    RPLPGR 
Sbjct: 3   LHLIYARAANGVIGKDGRLPWHLPQDMAHFRQLTQGCSVIMGRKTWDSLPARFRPLPGRS 62

Query: 59  NIILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           NI+++ Q     D      S+++A+A C       VIGG ++Y Q LP A  + +T I+ 
Sbjct: 63  NIVVTRQSDWHADGARRAASLEQALALCDARQTAWVIGGAQLYAQALPLADCVEVTEINQ 122

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + +GD H P     +W  +         Q+  ++ F    R
Sbjct: 123 DFDGDAHAPTLGA-EWVEIRRSRQP--DQHGLAFSFVRYAR 160


>UniRef50_A3HTR7 Dihydrofolate reductase n=1 Tax=Algoriphagus sp. PR1
           RepID=A3HTR7_9SPHI
          Length = 166

 Score =  191 bits (485), Expect = 9e-48,   Method: Composition-based stats.
 Identities = 58/161 (36%), Positives = 92/161 (57%), Gaps = 4/161 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLIAA+A + VIG  N + W +P D   FK  T    ++MGR T+ES+G+PLP R +++
Sbjct: 3   ISLIAAVAKNGVIGKGNDLVWKIPTDFKRFKAITSGNYILMGRKTFESLGKPLPNRTHLV 62

Query: 62  LSSQPGT--DDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +S        +     ++V++A   C    + ++ VIGGG +Y+Q +  A +L +T +DA
Sbjct: 63  ISRNKNYKVPEGHHLFENVEDAFIYCNKLGIEKLYVIGGGEIYKQTISIADELLITEVDA 122

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              GDT+FP+ + + W+ V  E   +D  N H + F   ER
Sbjct: 123 TPVGDTYFPEIDKNTWKIVSKESFPSDEINQHPFSFINYER 163


>UniRef50_C4FSY3 Putative uncharacterized protein n=1 Tax=Catonella morbi ATCC 51271
           RepID=C4FSY3_9FIRM
          Length = 169

 Score =  189 bits (481), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 59/163 (36%), Positives = 91/163 (55%), Gaps = 5/163 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           M++L+ A      IG +N +PW+LP DL +FK+ TL   ++MGR T+ES+G R LPGR +
Sbjct: 1   MLTLVYAQDQAGGIGYQNQLPWHLPNDLKFFKQVTLGHAILMGRKTFESMGCRLLPGRTS 60

Query: 60  IILSSQPGTD---DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
            +L+ Q       + +  V ++ EAI A  +  E+MVIGG  ++   LP A ++  T I 
Sbjct: 61  YVLTRQEDYKSEIEGLHRVHNL-EAIKALAEDQEVMVIGGAEIFAALLPLADRVIRTQIK 119

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           A    DT   D + D W+ V  +    D +N +++ FE   RR
Sbjct: 120 ATFPADTFVADLDQDQWQCVEIQEGLVDDKNQYAHQFEWWVRR 162


>UniRef50_B3PTQ3 Dihydrofolate reductase protein n=49 Tax=Proteobacteria
           RepID=B3PTQ3_RHIE6
          Length = 172

 Score =  189 bits (480), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 64/164 (39%), Positives = 103/164 (62%), Gaps = 7/164 (4%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           ++IAA+A + +IG +  MPW L +DL  FK  TL KPV+MGR T++SIG+PLPGR N+++
Sbjct: 7   TIIAAVARNGIIGRDGDMPWRLSSDLKRFKALTLGKPVVMGRKTYDSIGKPLPGRPNVVI 66

Query: 63  SSQPGTD-DRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           S Q   D   V    S+ EA+ A         V EI ++GGG++Y Q +  A ++ +TH+
Sbjct: 67  SRQAAIDHPDVAMAHSLAEAMDAAERLARETGVDEICIVGGGQIYAQAINLADRMCITHV 126

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +A+++GD  FPD +PD W++  +    A  ++S+   + + +RR
Sbjct: 127 EADLDGDASFPDIDPDLWQAAETIAVPAGEKDSYPTRYVVYKRR 170


>UniRef50_C6W5S3 Dihydrofolate reductase n=1 Tax=Dyadobacter fermentans DSM 18053
           RepID=C6W5S3_DYAFD
          Length = 183

 Score =  189 bits (480), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 62/161 (38%), Positives = 89/161 (55%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A A +  IG +N + W L  DL  FK+ TL  P+IMGR T+ESIG+PLPGR +I+
Sbjct: 20  ISIIVAAAENGAIGRDNQLLWRLSDDLKRFKQLTLGHPMIMGRKTFESIGKPLPGRTSIV 79

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D V  V S+DEA+      D  E+ ++GGG +YEQ    A  +YLT +   
Sbjct: 80  ITRNANFAFDGVVVVHSLDEALEKAKEIDSQEVCIVGGGEIYEQSQAIATHIYLTKVHTS 139

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           V GDT F   EP+ W       H+ D ++   + F    ++
Sbjct: 140 VVGDTFFSIREPEAWTETERISHEPDERHIFPFEFINYIKK 180


>UniRef50_B1XTJ0 Dihydrofolate reductase n=1 Tax=Polynucleobacter necessarius subsp.
           necessarius STIR1 RepID=B1XTJ0_POLNS
          Length = 162

 Score =  189 bits (480), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 66/158 (41%), Positives = 93/158 (58%), Gaps = 5/158 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A + + VIG +N MPW + ADL +FKR T+  PVIMGR TWESIGR LPGR+NI+
Sbjct: 6   ISMIVARSRNHVIGRDNQMPWKISADLQFFKRVTMGHPVIMGRKTWESIGRSLPGRRNIV 65

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S            V S+DEA+ +  + P + VIGG +++ Q   KA +LY+T ID ++E
Sbjct: 66  VSRNASYPISGGELVGSLDEALKSLNEFPRVFVIGGEQLFRQAFDKADRLYITEIDLDIE 125

Query: 121 -GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
            GDT F       W+ V        ++   ++ F  LE
Sbjct: 126 GGDTFFEVPNASAWKEVERTPG---SEGEITFSFITLE 160


>UniRef50_Q03S94 Dihydrofolate reductase n=4 Tax=Lactobacillus RepID=Q03S94_LACBA
          Length = 163

 Score =  188 bits (477), Expect = 7e-47,   Method: Composition-based stats.
 Identities = 54/162 (33%), Positives = 86/162 (53%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M+  + A +  RVIG+   +PW+LPAD+ +FK  T    ++ G  T+ S  RPLP RKNI
Sbjct: 1   MLIFLWAESQGRVIGLHGGLPWHLPADMHYFKTVTTGHTIVAGSKTFASFPRPLPNRKNI 60

Query: 61  ILSSQPGT--DDRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++S QP T   + V+ + S+    A AA     +I V+GG +++   L     LY T ID
Sbjct: 61  VVSHQPATAFPENVSVLHSLPAVRAYAAARPQEKIFVVGGAQLFAGLLDDVDFLYRTRID 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           A  +GDT  P  +   +  +  +    + +N + + FE  +R
Sbjct: 121 AGFDGDTWMPVIDYSQFTLIDQQPGIRNEKNPYDFVFEQYQR 162


>UniRef50_A1TM51 Dihydrofolate reductase n=4 Tax=cellular organisms
           RepID=A1TM51_ACIAC
          Length = 165

 Score =  187 bits (476), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 60/164 (36%), Positives = 86/164 (52%), Gaps = 7/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           + LI A A +  IG+ NAMPW+LP DLA FK+ TL   V+MGR TW+S+    RPLPGR 
Sbjct: 3   LRLIYARAANGGIGLHNAMPWHLPEDLAHFKQLTLGATVVMGRKTWDSLPARFRPLPGRT 62

Query: 59  NIILSSQPGTD-DRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           NI+++ Q G   D      S+++A+         + V+GG ++Y Q LP A  + +T I 
Sbjct: 63  NIVVTRQAGWHADGALSASSLEQAVELARPHGDTVWVMGGAQIYAQALPMADGVEVTEIH 122

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQN-SHSYCFEILERR 159
            + E D   P   P +WE          A + +  + F    RR
Sbjct: 123 RDFEADAFAPVLGP-EWEETARTPVQTSAGSAALPFSFVSYRRR 165


>UniRef50_C7X688 Dihydrofolate reductase n=7 Tax=Bacteroidales RepID=C7X688_9PORP
          Length = 165

 Score =  187 bits (476), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 58/161 (36%), Positives = 84/161 (52%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           IS+IAA+A    IG    +  ++P+D+  FK  T    VIMGR T+ES+   PLP RKN+
Sbjct: 4   ISIIAAIADKSAIGKNQQLLCHMPSDMKRFKELTTGHAVIMGRKTFESLPVAPLPNRKNV 63

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L++ P          +S+  A+  C    EI +IGG  VY Q L  A K+Y+T I  E 
Sbjct: 64  VLTTMPEAGFVNCFACESMGAALDLCEKEDEIFIIGGALVYRQALRIADKMYITRIHHEF 123

Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +  + FP    D WE    E + AD +N + Y +    R+
Sbjct: 124 PDATSFFPVVNWDLWEETEREEYPADEKNPYPYTYITYVRK 164


>UniRef50_B3ER85 Putative uncharacterized protein n=1 Tax=Candidatus Amoebophilus
           asiaticus 5a2 RepID=B3ER85_AMOA5
          Length = 164

 Score =  187 bits (475), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 65/163 (39%), Positives = 91/163 (55%), Gaps = 4/163 (2%)

Query: 1   MI-SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKN 59
           MI S+I A AV+ VIG +  +PW++PADL  FK  T    VIMGR T+ES+   LP RK 
Sbjct: 1   MIKSIIVAKAVNHVIGNKGRLPWHMPADLKHFKELTGGHHVIMGRKTFESLPGSLPDRKI 60

Query: 60  IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           IILS       +  T V S++ A+      +  E+ + GG  VY + L    K+YLT I 
Sbjct: 61  IILSQSLNYKVEDCTVVPSLEMALEIANQANETEVFIAGGAAVYREALGIVDKIYLTVIH 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +VEGDT FP  +   W  V    H+ D +++++Y F  L +R
Sbjct: 121 TDVEGDTFFPTLKDHQWTEVSIVSHNHDIKHAYAYDFIELAKR 163


>UniRef50_C6XMY9 Dihydrofolate reductase n=1 Tax=Hirschia baltica ATCC 49814
           RepID=C6XMY9_HIRBI
          Length = 182

 Score =  186 bits (474), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 67/166 (40%), Positives = 93/166 (56%), Gaps = 8/166 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           +++I A A + VIG++  +PW L  DL +FK  TL KPVIMGR TWES+  +PL GR N+
Sbjct: 15  LAMIVARAKNGVIGVDGDLPWRLKGDLKFFKSVTLGKPVIMGRKTWESLPFKPLKGRANL 74

Query: 61  ILSSQPGTDD-RVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           ++S +   D        S+  AIAA        DV E+M+IGGG +Y         LY+T
Sbjct: 75  VVSRRHDFDAQGARVFPSLGVAIAAGRAIADQTDVEEVMIIGGGAIYTAAFENVDVLYVT 134

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            ++ E EGDT FP+ + D W  V    H AD  N H++    L R+
Sbjct: 135 EVNTEPEGDTFFPEIDDDVWTCVEETNHAADEDNDHAFVMRKLVRK 180


>UniRef50_C8X9J8 Dihydrofolate reductase n=1 Tax=Nakamurella multipartita DSM 44233
           RepID=C8X9J8_NAKMY
          Length = 292

 Score =  186 bits (473), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 65/160 (40%), Positives = 90/160 (56%), Gaps = 10/160 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + L+AA+A + VIG    MPW++PADL  FKR T+  P++MGR T+ES+G  LPGR++I+
Sbjct: 8   VVLVAAVARNGVIGAAGTMPWHIPADLKRFKRLTMGHPMVMGRKTFESMG-LLPGRRSIV 66

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAA-CGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++  P           S+D AIA      P +MV+GGG +Y Q LP+A +L +TH+D   
Sbjct: 67  ITRDPHWRAPGAEVADSLDRAIALGAQTDPVVMVVGGGEIYAQALPRADRLEITHLDLSA 126

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GDT FP  +P  W     E  D        Y F    RR
Sbjct: 127 PGDTVFPAIDPALWAVTDREEADG-------YAFVTYRRR 159


>UniRef50_B8F4S8 Dihydrofolate reductase n=5 Tax=Pasteurellaceae RepID=B8F4S8_HAEPS
          Length = 165

 Score =  186 bits (473), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 74/160 (46%), Positives = 105/160 (65%), Gaps = 4/160 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A  +++VIG +NAM W+LP DLAWF+ NTL KPVIMGR T+ESIGR LP R NII
Sbjct: 3   ISVIVARTLNKVIGKDNAMLWHLPVDLAWFRENTLGKPVIMGRKTYESIGRLLPKRPNII 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACG---DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           LS      D      S+++A+       +  EIM++GGG +++Q +P A KLYLT I A 
Sbjct: 63  LSRSGFAIDGAYSAISLEQAVELAKNFANSDEIMILGGGELFKQTMPFADKLYLTEIQAN 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +EGDT F +++   W+ +  ++ + D QNS+   F IL++
Sbjct: 123 IEGDTFF-EFDETQWQQIAEKWSEIDEQNSYRCRFMILDK 161


>UniRef50_A8YUW1 Dihydrofolate reductase n=12 Tax=Lactobacillus RepID=A8YUW1_LACH4
          Length = 172

 Score =  185 bits (470), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 56/167 (33%), Positives = 89/167 (53%), Gaps = 8/167 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI  + A      IG++  +PW LPAD+A FK  T+  P+IMGR T+ S+ R LP RK+I
Sbjct: 1   MIEFVWAEDQKHQIGLDGHLPWRLPADMAHFKEKTIGHPIIMGRKTFMSLPRLLPQRKHI 60

Query: 61  ILSSQPGT------DDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYL 112
           +L+           +D+VT + S+ E      +    ++  +GG  +++  L +   L  
Sbjct: 61  VLTHDQDLKKKYQDNDQVTIINSIAELGDYIQNHQGEKLCTVGGVSIFKALLDQVDVLEK 120

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T IDA  E DT  P+ + D ++ V  E H+AD +N + Y F   +R+
Sbjct: 121 TEIDATFEADTVMPEIDYDQFKLVKKEHHEADEKNKYPYTFFTYQRK 167


>UniRef50_Q134B2 Dihydrofolate reductase n=10 Tax=Bradyrhizobiaceae
           RepID=Q134B2_RHOPS
          Length = 179

 Score =  185 bits (470), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 65/164 (39%), Positives = 91/164 (55%), Gaps = 7/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I +I A+A + VIG  NA+PW L +D   FK+ TLNKPVIMGR T++SIGRPLPGR NI+
Sbjct: 12  IVIIVAVAENGVIGEGNAIPWRLKSDQRRFKQLTLNKPVIMGRKTYQSIGRPLPGRTNIV 71

Query: 62  LSSQ-PGTDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           ++         V    S + A              E++V+GG  +Y  +LP+A  + LT 
Sbjct: 72  VTRDTHFQAAGVVVAPSFEAAERVAAGDAMRRSATEVVVVGGSEIYAHWLPRATCIELTE 131

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + A  +GDT FP  +PD WE V    H A  ++S  + +    R
Sbjct: 132 VHASPQGDTTFPAIDPDQWEEVARTRHGAGPEDSVEFSYVTYRR 175


>UniRef50_C6W102 Dihydrofolate reductase n=1 Tax=Dyadobacter fermentans DSM 18053
           RepID=C6W102_DYAFD
          Length = 167

 Score =  185 bits (470), Expect = 5e-46,   Method: Composition-based stats.
 Identities = 60/160 (37%), Positives = 102/160 (63%), Gaps = 2/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+IAA++ + VIG+ N++PW+LP + A F++ T  K  IMGR ++E+        +N+I
Sbjct: 7   LSIIAAMSENHVIGLNNSLPWHLPDEWAHFRKVTAGKAFIMGRKSFEAPDALHSEYRNVI 66

Query: 62  LSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S+P    + RV + + +  AIA   D  ++ V+GG  V+EQ LP A ++YLT + A+V
Sbjct: 67  ITSRPPAQAEPRVEYARDISGAIALLSDETDVFVLGGASVFEQMLPLADRMYLTIVHAQV 126

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD  FP ++ DDW+   SEFH AD  +++++   +  R+
Sbjct: 127 EGDAFFPAFDSDDWQLADSEFHGADDDHAYAFSMNLYIRK 166


>UniRef50_D1QNC5 Dihydrofolate reductase n=1 Tax=Prevotella oris F0302
           RepID=D1QNC5_9BACT
          Length = 160

 Score =  184 bits (469), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 65/161 (40%), Positives = 95/161 (59%), Gaps = 4/161 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKN 59
           ++SLIAA+A +R IG +N + +++  DL  FKR T+   VIMGRHT+ES+    LP RKN
Sbjct: 2   ILSLIAAVARNRAIGYQNRLLFHIKTDLEHFKRLTMGHVVIMGRHTFESLPNGALPHRKN 61

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++S    +    T V S  EA+  C    E+ VIGG +VY++ + +A +LYLT IDA  
Sbjct: 62  IVISKSVASFHGCTRVSSFKEALDMCQTEEEVFVIGGEQVYKEAITQADRLYLTEIDALA 121

Query: 120 E-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E  D +FP  + + W  V  E H     N  ++ F + +RR
Sbjct: 122 EQADAYFP--DYNSWHLVAHEAHKKSEDNPFAFAFTVYQRR 160


>UniRef50_B2TR57 Dihydrofolate reductase n=10 Tax=Clostridium RepID=B2TR57_CLOBB
          Length = 164

 Score =  184 bits (468), Expect = 7e-46,   Method: Composition-based stats.
 Identities = 58/162 (35%), Positives = 91/162 (56%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M+S+I A+A + VIG +N + W++  DL  FK  T  K ++MGR T+ES+   LP RK+I
Sbjct: 1   MLSIIVAIAKNNVIGNDNKLIWHISEDLKRFKEITSGKTIVMGRKTFESLPGVLPNRKHI 60

Query: 61  ILSSQPGTD---DRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           IL+         + V  +   DE +    +   E+ +IGGG +Y+Q LP + KLYLT I+
Sbjct: 61  ILTRDKNFKVNSECVEIIYDFDELLNKYKNSDDEVFIIGGGEIYKQLLPYSNKLYLTKIN 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            + +GDT+FP    +D++  +      D ++   Y F  L R
Sbjct: 121 KDFDGDTYFPQINYNDFKIDYESDVITDEKSGLEYKFINLSR 162


>UniRef50_UPI00017452A7 Dihydrofolate reductase n=1 Tax=Verrucomicrobium spinosum DSM 4136
           RepID=UPI00017452A7
          Length = 167

 Score =  184 bits (468), Expect = 7e-46,   Method: Composition-based stats.
 Identities = 58/161 (36%), Positives = 82/161 (50%), Gaps = 11/161 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGR 57
           +  IAA+A +RVIG +  +PW+LP DL +FK+ T   PV+MGR T+ESI    G+PLP R
Sbjct: 11  LIAIAAMASNRVIGRDGTLPWHLPEDLKFFKKTTAGHPVLMGRKTFESIVAALGKPLPNR 70

Query: 58  KNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +NI+LSS     + V  +  +            + +IGG ++YE  LP   +L LT ID 
Sbjct: 71  RNIVLSSTLAPQEGVEVIPHLASLSQLSALTSPVYLIGGAQLYEALLPVCDELLLTWIDQ 130

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             EGD  FP +   D+       H         + F    R
Sbjct: 131 PYEGDAFFPAF-EGDFSLREVLGHGEG------FEFRRYVR 164


>UniRef50_D0XKH5 Dihydrofolate reductase n=1 Tax=Brevundimonas subvibrioides ATCC
           15264 RepID=D0XKH5_9CAUL
          Length = 175

 Score =  184 bits (468), Expect = 7e-46,   Method: Composition-based stats.
 Identities = 66/169 (39%), Positives = 99/169 (58%), Gaps = 12/169 (7%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           I+L+ A A + VIG +  +PW L +DL  FK+ TL KP IMGR TWES+  RPLPGR N+
Sbjct: 6   IALVVARARNGVIGRDGDLPWKLRSDLQRFKQITLGKPCIMGRSTWESLPLRPLPGRLNL 65

Query: 61  ILSSQPGTDD-----RVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQK 109
           +LS     ++           ++ +AI    +      + EI VIGG  ++E  LP+A++
Sbjct: 66  VLSRDLSYEERGKAKGAVVCSNLADAIDMARETAEDDGIDEICVIGGTALFEAALPRAKR 125

Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           LY+T ++AE EGD  FP ++   +    +E HDA  ++ H + F IL+R
Sbjct: 126 LYITEVEAEPEGDALFPAFDESLFAETLNERHDAGEKDDHPFVFRILDR 174


>UniRef50_Q5HPB1 Dihydrofolate reductase n=24 Tax=Bacilli RepID=DYR_STAEQ
          Length = 161

 Score =  184 bits (467), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 56/159 (35%), Positives = 89/159 (55%), Gaps = 4/159 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S+I A    RVIG +N +PW+LP DL   K+ T    ++MGR T+ SIG+PLP R+N++
Sbjct: 3   LSIIVAHDKQRVIGYQNQLPWHLPNDLKHVKQLTTGNTLVMGRKTFNSIGKPLPNRRNVV 62

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L++Q     + V  + S+DE          + + GG  ++E  + +   +Y+T ID + +
Sbjct: 63  LTNQASFHHEGVDVINSLDEIKEL---SGHVFIFGGQTLFEAMIDQVDDMYITVIDGKFQ 119

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FP Y  ++WE   S     D +N+  + F  L RR
Sbjct: 120 GDTFFPPYTFENWEVESSVEGQLDEKNTIPHTFLHLVRR 158


>UniRef50_A6L1Q7 Dihydrofolate reductase n=34 Tax=Bacteroidales RepID=A6L1Q7_BACV8
          Length = 164

 Score =  183 bits (466), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 57/160 (35%), Positives = 91/160 (56%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           IS+I A+A +  IG EN + + LP DL  FK  T    +IMGR T+ES+ +  LP R+NI
Sbjct: 3   ISIIVAIARNHGIGFENKLLYWLPNDLKRFKALTTGHTIIMGRKTFESLPKGALPNRRNI 62

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI-DAE 118
           +LS + G          +++ A++ C +  EI +IGG  +Y++ +  AQ+LY+T I D  
Sbjct: 63  VLSRREGAVFAGAECFPALEIALSHCKEEEEIFIIGGASLYKEAMHIAQQLYITFIDDTS 122

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            E D +FP+ + ++W+    E H  D ++ + Y F    R
Sbjct: 123 KEADAYFPEIKKEEWKETGREDHPTDEKHLYPYSFINYSR 162


>UniRef50_B2I6E9 Dihydrofolate reductase n=11 Tax=Xanthomonadaceae
           RepID=B2I6E9_XYLF2
          Length = 188

 Score =  183 bits (464), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 72/163 (44%), Positives = 97/163 (59%), Gaps = 4/163 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           ++SLIAAL   R IG +N +PW+LP DL  FK  TL +PV+MGR T  S+GRPLPGR N+
Sbjct: 24  IVSLIAALDRYRAIGRDNGLPWHLPDDLKRFKALTLGRPVLMGRKTAHSLGRPLPGRTNL 83

Query: 61  ILSSQPGTD-DRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +L+         +  V S+D AI  AA      + VIGGG +Y   LP A  +YLTH+D 
Sbjct: 84  VLTRSGHVPFSEMRAVDSLDAAIVQAAAEGADTLSVIGGGELYALTLPHANAMYLTHVDV 143

Query: 118 EVEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            V G DT+FP ++  DWE    E H  D ++++ + F    RR
Sbjct: 144 AVAGADTYFPMFDAVDWEIKNREPHQGDGRHAYPFTFIDYCRR 186


>UniRef50_C1IBP0 Dihydrofolate reductase n=1 Tax=Clostridium sp. 7_2_43FAA
           RepID=C1IBP0_9CLOT
          Length = 161

 Score =  182 bits (463), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 58/159 (36%), Positives = 89/159 (55%), Gaps = 2/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MISLI A+  +  IG +N +  ++  DL +FKR T    ++MG +T+ S+  RPLP R+N
Sbjct: 1   MISLIVAMDKNNGIGNKNKLLAHISEDLRYFKRVTDGNTIVMGYNTYMSLPKRPLPNRRN 60

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I+L+++    +    V S++E +       E  + GG  +Y Q LP A KLY+THI  E 
Sbjct: 61  IVLTTKDIKLEGAVVVNSIEELLKLLNTEEETFICGGSSIYNQMLPYADKLYITHIFDEF 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E DT+FP+   D+WE   S  H  +  + H + F I  +
Sbjct: 121 EADTYFPEI-TDEWEISESFCHKENINHKHPHIFTIYTK 158


>UniRef50_Q1WU16 Dihydrofolate reductase n=5 Tax=Lactobacillus RepID=Q1WU16_LACS1
          Length = 167

 Score =  182 bits (463), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 56/167 (33%), Positives = 87/167 (52%), Gaps = 8/167 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS + A      IG +  +PW LPADLA FK  T+  P++MG+ T++S    LP R++I
Sbjct: 1   MISFVWAEDQKHQIGYKGHLPWRLPADLAHFKEVTMGHPMVMGKKTFDSFPGLLPRRQHI 60

Query: 61  ILSSQPGTDD------RVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYL 112
           +L+     ++      +V  + S+DE  +   +    E+ VIGG  ++   L K  KLY 
Sbjct: 61  VLTHDTNLEEKYKDNPQVEIMNSIDELTSWLDENQFQEVSVIGGAMLFNLLLNKVDKLYK 120

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T I +E  GDT  P    D+++ V  +    D +N + Y F   ER+
Sbjct: 121 TEILSEFNGDTVMPTINYDEFKLVSKKIGKVDEKNKYPYVFLEYERK 167


>UniRef50_C1SJK6 Dihydrofolate reductase n=1 Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SJK6_9BACT
          Length = 156

 Score =  181 bits (461), Expect = 5e-45,   Method: Composition-based stats.
 Identities = 53/157 (33%), Positives = 84/157 (53%), Gaps = 8/157 (5%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62
           +LI A+  DRVIG  N MPW+LP DL  FK  T    + MGR T+ESIGRPLP R+N ++
Sbjct: 4   ALIVAMTKDRVIGKNNDMPWHLPEDLKLFKAKTTGHIIAMGRKTYESIGRPLPNRENFVI 63

Query: 63  SSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           +      D      SV E I A  +  + +  IGGG++Y   +    ++++++I    +G
Sbjct: 64  TRSGKEYDGCRVFGSVQECIKAAEEYDKTLFFIGGGQIYSDAVDMVDEMHISYIKENYDG 123

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           DT FP+++   W+   +E +         + ++   R
Sbjct: 124 DTFFPEFDESRWKVTETEEYG-------DFIYKKFVR 153


>UniRef50_C4L1C8 Dihydrofolate reductase region n=2 Tax=Exiguobacterium
           RepID=C4L1C8_EXISA
          Length = 162

 Score =  181 bits (461), Expect = 5e-45,   Method: Composition-based stats.
 Identities = 55/159 (34%), Positives = 89/159 (55%), Gaps = 3/159 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS + A   +R IG +N + W LP DL  FK  T    V+MGR T+ESIG+ LP R+NI
Sbjct: 1   MISHVVAYGQNREIGKDNDLLWRLPDDLKHFKAITSGGTVVMGRKTFESIGKALPNRRNI 60

Query: 61  ILSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++S    + D+V     +D  +A      E  VIGG  +YEQ +P   ++Y T + A  
Sbjct: 61  VVTSDVSFSADQVEVWHDLDR-LAEMSQQEEWFVIGGAMLYEQTMPMTSRIYATEVAASF 119

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E DT++P+ +  +W    +  H  D  +++++ F+  ++
Sbjct: 120 EADTYYPE-QTGEWSVTSTIDHPQDETHAYAFSFKQYDK 157


>UniRef50_B6INW3 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria
           RepID=B6INW3_RHOCS
          Length = 190

 Score =  181 bits (460), Expect = 6e-45,   Method: Composition-based stats.
 Identities = 67/166 (40%), Positives = 91/166 (54%), Gaps = 8/166 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           + L+AA+A + VIG  N +PW LP DL +FKR T+ KPV+MGR TWESIG +PLPGR NI
Sbjct: 24  LVLVAAVARNGVIGRGNTLPWRLPGDLRFFKRTTMGKPVVMGRRTWESIGAKPLPGRCNI 83

Query: 61  ILSSQP-GTDDRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +L+       +          AIA           PE+ VIGG  ++ + L  A +LYLT
Sbjct: 84  VLTRDTGFAPEGAIVCHGFLGAIAEARSVAARTGAPEVCVIGGESLFAEALRMADRLYLT 143

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + AE  GD  FP ++   W     E  DA   +S +Y    L+R+
Sbjct: 144 EVLAEPAGDVLFPPFDRGAWMQTELERADAAGPDSPAYRILRLDRK 189


>UniRef50_A7IF75 Dihydrofolate reductase n=3 Tax=Rhizobiales RepID=A7IF75_XANP2
          Length = 178

 Score =  181 bits (460), Expect = 6e-45,   Method: Composition-based stats.
 Identities = 55/165 (33%), Positives = 93/165 (56%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++L+ A++ + VIG +  +PW LP+DL  F+  T  KP++MGR T+ESIGRPLPGR +++
Sbjct: 11  LALVVAVSQNGVIGTDGGLPWRLPSDLKRFRALTWGKPLLMGRRTYESIGRPLPGRTSVV 70

Query: 62  LSSQPGT--DDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +S+ P     + V    S+++ +    +        EIMVIGG R++   LP A+ L+LT
Sbjct: 71  VSTDPAFTVPEGVLKGASLEDGLRLADEAADAMGADEIMVIGGARLFHDTLPLARTLHLT 130

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            + A  +GD  FP ++   W  +  +      ++  ++    L R
Sbjct: 131 QVHAAPDGDVFFPAFDEAQWREIARDGPIQGEKDEAAFTALTLVR 175


>UniRef50_B2SDZ8 Dihydrofolate reductase n=19 Tax=Francisella RepID=B2SDZ8_FRATM
          Length = 180

 Score =  181 bits (459), Expect = 8e-45,   Method: Composition-based stats.
 Identities = 60/162 (37%), Positives = 91/162 (56%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MISLI A   +  IG EN + W L  DL  FK+ T N  ++MGR T+ESIGRPLP RKNI
Sbjct: 15  MISLIVAYDKNFGIGKENTLAWKLSEDLKNFKKITENNYIVMGRKTFESIGRPLPNRKNI 74

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           IL+       D+   + S  + +         EI +IGG ++Y++FL  A +LY+T +DA
Sbjct: 75  ILTRDKDYKQDKCLIINSTQDILNFAESKPHYEIFIIGGAQIYKEFLKYADRLYITEVDA 134

Query: 118 EV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E+ + D  FP ++   ++ +  +    D +N   + F + E+
Sbjct: 135 EMTDLDAFFPQWDKSKYKRIGHKQFKKDDKNEFDFTFSVFEK 176


>UniRef50_A6GQA5 Dihydrofolate reductase n=1 Tax=Limnobacter sp. MED105
           RepID=A6GQA5_9BURK
          Length = 188

 Score =  181 bits (459), Expect = 9e-45,   Method: Composition-based stats.
 Identities = 57/183 (31%), Positives = 92/183 (50%), Gaps = 26/183 (14%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S++AA+A + +IG+ N++PW+LP DLA+FK+ TL  PV+MGR T+ESI RPLPGR N++
Sbjct: 3   VSIVAAVAENGIIGINNSLPWHLPEDLAFFKQTTLGCPVLMGRKTYESINRPLPGRLNVV 62

Query: 62  LSSQPGTDD------------------------RVTWVKSVDEAIAACGDVPEIMVIGGG 97
           LSS                              ++    ++ +A+       ++ +IGG 
Sbjct: 63  LSSNSDWKPAPGKDGTPRSVITHPAALPEGSATQIATATNLPDALNWLSSFEQVFLIGGS 122

Query: 98  RVYEQFLP--KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEI 155
            +YEQ L      +L LT I    EGD  FP ++   +  V    + A  + +  + F  
Sbjct: 123 NLYEQALAQGLVDELILTEIHQSFEGDASFPQWDRQQFREVDRITNTATPERAWGFDFVK 182

Query: 156 LER 158
             +
Sbjct: 183 YAK 185


>UniRef50_A4BS77 Dihydrofolate reductase n=1 Tax=Nitrococcus mobilis Nb-231
           RepID=A4BS77_9GAMM
          Length = 162

 Score =  180 bits (458), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 61/153 (39%), Positives = 88/153 (57%), Gaps = 1/153 (0%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67
           +A +RVIG  + +PW LPAD+  F   T  KP++MGR   ++IGR LPGR NI+LS  P 
Sbjct: 1   MAENRVIGRAHGLPWRLPADMRHFVALTRGKPIVMGRRCHDTIGRALPGRHNIVLSRNPA 60

Query: 68  -TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126
                   V  ++ A+A      EIM+IGG ++Y  FL +A ++YLT +   VEGD  FP
Sbjct: 61  HRVPGCMLVHDLEAALAVAAGASEIMIIGGEQIYRLFLARADRIYLTLVHGRVEGDAFFP 120

Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
             +  +W+    +   ADA N+++  F  L RR
Sbjct: 121 HLDAAEWQESARQSRLADADNAYALTFLTLLRR 153


>UniRef50_B6YRF0 Dihydrofolate reductase n=1 Tax=Candidatus Azobacteroides
           pseudotrichonymphae genomovar. CFP2 RepID=B6YRF0_AZOPC
          Length = 164

 Score =  180 bits (458), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 56/160 (35%), Positives = 83/160 (51%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           +S+IA+L  +  IG EN +   LPADL  F++ TL   +IMGR T++S+    LP R+NI
Sbjct: 3   LSIIASLGRNNEIGKENRLLCYLPADLKHFRKITLGHSIIMGRKTFDSLPNGILPDRENI 62

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I+S              S+D A++   +  E+ +IGG ++Y+Q LP    LYLT + A  
Sbjct: 63  IISRNGSLAIKNARVYTSLDFALSKLMNEEEVFIIGGAQIYQQTLPIVNNLYLTKVYATF 122

Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            E D  FP     +W     E   A+ +N +   F   ER
Sbjct: 123 PEADVFFPLINYSEWHETEQEKIPANTKNPYPISFTKYER 162


>UniRef50_C8NE93 Dihydrofolate reductase n=24 Tax=Lactobacillales RepID=C8NE93_9LACT
          Length = 169

 Score =  180 bits (457), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 55/162 (33%), Positives = 87/162 (53%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           M+  I A     ++G +  +PW LP DL +FK  T+ + ++MGR T+E +G R LPGR+ 
Sbjct: 1   MLIYIWAQDERGLVGKDGTLPWRLPNDLKFFKEVTMGQTILMGRKTFEGMGSRLLPGRQT 60

Query: 60  IILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           IIL++           V +++E +       +I V GG +VY       + LY T I A 
Sbjct: 61  IILTTSSDYIVPGAEVVTNIEEIVEDSR-HEDIYVCGGAQVYNLLKNHVELLYCTRIHAS 119

Query: 119 VEGDTHFP-DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            EGD++FP ++   D+  V S   + D +N + + FEI ER+
Sbjct: 120 FEGDSYFPTEFPWHDFIKVKSLEGEIDEKNLYPHTFEIYERK 161


>UniRef50_Q6MID1 FolA protein n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MID1_BDEBA
          Length = 169

 Score =  179 bits (456), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 51/172 (29%), Positives = 88/172 (51%), Gaps = 17/172 (9%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59
           +++ + A + +RVIG +  +PW+LP D+ +F+  T    +IMGR T++S  GR LP R +
Sbjct: 2   ILTHVVACSQNRVIGAQGGLPWSLPEDMKFFRETTKGHIMIMGRKTFDSFNGRALPNRYH 61

Query: 60  IILSSQPG-------TDDRVTWVKSVDEAIAACGD-----VPEIMVIGGGRVYEQFLPKA 107
           I+++  P            V +V S++EA+            E+ +IGGG +Y+Q +P  
Sbjct: 62  IVVTRDPSKQSFNSTESSPVVFVASIEEAVKHAEPLTAKWGDEVFIIGGGEIYKQAMPIT 121

Query: 108 QKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            K+YLT I  E  GDT++P+ +   +          D +    + F    R+
Sbjct: 122 DKIYLTLIHREFPGDTYYPEIDEKVFTQTERR----DIETPIPFSFLTYLRK 169


>UniRef50_B9LR90 Dihydrofolate reductase region n=2 Tax=Halobacteriaceae
           RepID=B9LR90_HALLT
          Length = 194

 Score =  179 bits (456), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 65/171 (38%), Positives = 94/171 (54%), Gaps = 14/171 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWES----IGRPLPGR 57
           + L+AA+A +RVIG +  MPW+ PADLA FKR T   PVI+GR T+ES    IG PLP R
Sbjct: 21  LVLVAAVAENRVIGDDGGMPWHYPADLARFKRLTTGHPVIVGRATYESIADRIGGPLPDR 80

Query: 58  KNIIL-SSQPGTDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKL 110
            +++L +      +       +DEA+           V ++ VIGG  VYEQFL +A ++
Sbjct: 81  TSVVLTTRDLDLPEGAVVANDLDEAVDLAGADAADRGVDDVYVIGGATVYEQFLDRADRM 140

Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNS---HSYCFEILER 158
            LT +  + +GDT FPD++ ++W     E   AD +      +  F   ER
Sbjct: 141 VLTEVPEQPDGDTRFPDWDDEEWVETEREVVGADGERGGEADALAFVTYER 191


>UniRef50_Q03F97 Dihydrofolate reductase n=2 Tax=Pediococcus RepID=Q03F97_PEDPA
          Length = 161

 Score =  178 bits (453), Expect = 5e-44,   Method: Composition-based stats.
 Identities = 57/161 (35%), Positives = 90/161 (55%), Gaps = 4/161 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+I A  +   IG + ++PW++P D+A+FK+ T    V+MGR T++SIG+ LP RKNI
Sbjct: 1   MISMIWAEDLRHGIGKQQSIPWHIPGDMAFFKKTTSGNTVVMGRKTFDSIGKALPNRKNI 60

Query: 61  ILSSQP-GTDDRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +LS  P    D V  V S+ E  AI       +  +IGG  +Y   L +A +L +T I  
Sbjct: 61  VLSHHPTSLPDSVVGVGSLSELQAIFETHPNEKFYIIGGSHLYNALLSQADELLITRIQK 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + + +   PD   ++++   S  H++  +N  +Y FE   R
Sbjct: 121 DYQCEVLAPDITQNEFKLASSVEHESTERNP-AYTFETWIR 160


>UniRef50_B9ECC1 Putative uncharacterized protein n=1 Tax=Macrococcus caseolyticus
           JCSC5402 RepID=B9ECC1_MACCJ
          Length = 164

 Score =  178 bits (451), Expect = 7e-44,   Method: Composition-based stats.
 Identities = 60/160 (37%), Positives = 93/160 (58%), Gaps = 5/160 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAA++ + VIG +  +PW +P +   FK  T+ K VIMGR T+ESIG+PLP RK I
Sbjct: 2   IISLIAAISSNYVIGKDKDIPWKIPGEQVRFKDLTMGKSVIMGRKTFESIGQPLPNRKTI 61

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I+S     + +    V+S++ A        EI + GGG +Y++ LP A ++YLT I+ E 
Sbjct: 62  IISKSKDINYNNCLTVESLERAFNLLQQEDEIFIAGGGEIYKESLPFADRIYLTIIEKEY 121

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EG+  FP +  D++E  + +      +    Y +   ER+
Sbjct: 122 EGNIFFPMFNKDEFEITYQQKV----EGFIPYTYFTYERK 157


>UniRef50_Q38WX9 Dihydrofolate reductase n=5 Tax=Lactobacillales RepID=Q38WX9_LACSS
          Length = 166

 Score =  177 bits (450), Expect = 9e-44,   Method: Composition-based stats.
 Identities = 52/163 (31%), Positives = 90/163 (55%), Gaps = 5/163 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKN 59
           MI+ + A   + +IG +  +PW LP DLA FKR T+N+ VIMGR T++S+ + PLPGR+N
Sbjct: 1   MIAFLWAEDQNGLIGQDGHLPWRLPNDLANFKRETINEAVIMGRKTYDSLPKKPLPGRQN 60

Query: 60  IILSSQPGT--DDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHI 115
           I+++ Q G      V       + +    + P  ++ +IGG  +++ F      LY+T I
Sbjct: 61  IVITRQSGLTVAKDVLVFNERTQLLDYQKEHPMQKLFIIGGADIFKLFAADVDYLYVTKI 120

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             + +GD + P  +   ++ +  +    D +N + + FEI +R
Sbjct: 121 AEKFKGDVYMPTIDYTQFKLISQKAGAVDERNQYPHTFEIYQR 163


>UniRef50_Q2W7P5 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q2W7P5_MAGSA
          Length = 175

 Score =  177 bits (449), Expect = 1e-43,   Method: Composition-based stats.
 Identities = 73/162 (45%), Positives = 99/162 (61%), Gaps = 9/162 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A+A + VIG +NA+PW++P DL WFK NTL KPVIMGR TWESIGRPLP R NI+
Sbjct: 17  VALIVAVAANGVIGKDNALPWHIPEDLKWFKENTLGKPVIMGRKTWESIGRPLPKRPNIV 76

Query: 62  LSSQPGT-DDRVTWVKSVD----EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++ Q G   +      S+D     A     +  E+MVIGG  ++ + LP A++LYLT I 
Sbjct: 77  VTRQTGWRAEGAHTAHSLDEALALAARLAPEAAELMVIGGNSLFAEALPGARRLYLTEIA 136

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              EGDT FP +E   W  V    ++ D     ++ F IL+R
Sbjct: 137 RAYEGDTMFPAFERGLWHEVSRRRNEGD----PAFDFVILDR 174


>UniRef50_B5EIA1 Dihydrofolate reductase region n=5 Tax=Geobacter RepID=B5EIA1_GEOBB
          Length = 306

 Score =  177 bits (449), Expect = 1e-43,   Method: Composition-based stats.
 Identities = 59/158 (37%), Positives = 91/158 (57%), Gaps = 4/158 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +IS IAAL+ +RVIG +  +PW++P+DL  F+  T+   VIMGR T+ESIG PL GR+NI
Sbjct: 2   IISTIAALSDNRVIGADGGLPWDIPSDLTRFRSITMGHTVIMGRKTYESIGHPLLGRRNI 61

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +L+ +    +     ++V  AIAA     E+ + GGG V+++ LP  Q+LYLT +     
Sbjct: 62  VLTRKGSQIEGCEIARNVPAAIAAAEGEEEVFICGGGEVFQEALPLCQRLYLTVVHGNYR 121

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           GD   P+  P+ +  +  E        +    F +LE+
Sbjct: 122 GDAFLPEL-PEGFVELHREEFP---DTTPPSSFVVLEK 155


>UniRef50_B6BUF2 Dihydrofolate reductase n=1 Tax=beta proteobacterium KB13
           RepID=B6BUF2_9PROT
          Length = 148

 Score =  176 bits (448), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 46/152 (30%), Positives = 77/152 (50%), Gaps = 6/152 (3%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67
           ++ + VIG++N++PW+L  DL  FK  T    ++MGR T+ESIG+PLP R N +L+    
Sbjct: 1   MSENNVIGIDNSLPWHLSGDLKRFKAITTGHQIVMGRKTYESIGKPLPNRVNFVLTRNSD 60

Query: 68  TD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126
              D V  + S+++         +  +IGGG +Y Q +    +L +T I  E+ GD  FP
Sbjct: 61  LKIDGVHVISSLNDI---SDSDKKTFIIGGGEIYSQLIDSCDELLVTKIHREIHGDAFFP 117

Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             +   W  V     +   +N   + +    +
Sbjct: 118 MIDASVWSLVDQ--SEKLNENDIEFSYLTYRK 147


>UniRef50_Q044A0 Dihydrofolate reductase n=13 Tax=Lactobacillus RepID=Q044A0_LACGA
          Length = 171

 Score =  176 bits (447), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 60/167 (35%), Positives = 86/167 (51%), Gaps = 8/167 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI  I A   D  IG +  +PW+LPADL  FK  T N  ++MGR T+ES    LP R++I
Sbjct: 3   MIRFIWAEDEDGHIGYQGTLPWHLPADLKHFKDLTSNHIIVMGRRTFESFPGLLPKRQHI 62

Query: 61  ILSSQP------GTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYL 112
           ILS+ P        +  V     + E      D  E  I +IGG RV+E+F+ +   +  
Sbjct: 63  ILSTSPTLQRKYQNNAHVKIFSQLKELKNWIKDHSEQTIDIIGGARVFEEFMDEVDMIEK 122

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           T I    +GDT  P    +D+E + ++ H AD +N  +Y F   ER+
Sbjct: 123 TKIHHVFKGDTLMPKINYEDFELINTKAHQADEKNKFAYDFLEYERK 169


>UniRef50_UPI0001C37DF3 dihydrofolate reductase n=1 Tax=Ruminococcus flavefaciens FD-1
           RepID=UPI0001C37DF3
          Length = 160

 Score =  176 bits (447), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 60/161 (37%), Positives = 91/161 (56%), Gaps = 8/161 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MIS+IAA A + VIG    +PW++P D+A+F+R T    VIMGR T+E IGRPLPGR N+
Sbjct: 1   MISIIAAAAKNGVIGAGGKIPWDIPEDMAYFRRITYGGAVIMGRRTYEDIGRPLPGRFNV 60

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           ++S++  T  +      S+ EA+   G+     I + GG  VY + L  A ++YLT +D 
Sbjct: 61  VVSAKMQTAPEGTALAHSLAEAVEIAGNSGRENIFLCGGAAVYREGLAFADRIYLTILDK 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           E  GD +FP++   ++     E  D+         F I ++
Sbjct: 121 EYSGDVYFPEFSEKEFRLTSYERCDSA-----PITFCIYDK 156


>UniRef50_Q0C500 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria
           RepID=Q0C500_HYPNA
          Length = 176

 Score =  176 bits (447), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 68/165 (41%), Positives = 89/165 (53%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           + LI A A +R+IG   A+PW L  D+A+FK  T+  PVIMGR TWES   RPLPGR+NI
Sbjct: 7   LCLIVAQARNRIIGAAGALPWRLKDDMAFFKATTMGAPVIMGRKTWESFPKRPLPGRENI 66

Query: 61  ILSSQPGTDD-RVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +L+     D        S   A+ A           E  VIGG  +Y   LP A ++YLT
Sbjct: 67  VLTRDWDYDAAEARVYSSFPAAMNAARAIAAREGKDEAFVIGGAEIYALALPFADRIYLT 126

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            +DAE+EGDT FP+ +   W S     H A   N H++    L+R
Sbjct: 127 EVDAEIEGDTLFPELDLRQWRSDEIATHPAGEGNDHAFIIRRLDR 171


>UniRef50_B2ICT5 Dihydrofolate reductase n=2 Tax=Beijerinckiaceae RepID=B2ICT5_BEII9
          Length = 198

 Score =  175 bits (445), Expect = 3e-43,   Method: Composition-based stats.
 Identities = 58/165 (35%), Positives = 89/165 (53%), Gaps = 7/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++++AALA +RVIG+  AMPW+LP D   F+  T  KP++MGR T+ESIGR LPGR+ I+
Sbjct: 25  LTIVAALADNRVIGLNQAMPWDLPGDRRHFRERTWGKPMLMGRKTFESIGRALPGRETIV 84

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIM------VIGGGRVYEQFLPKAQKLYLTH 114
           L+         V     ++ A+    D   IM      ++GGG ++   LP+ ++L LT 
Sbjct: 85  LTRDETFAAPGVLVAHDLEGALGLAHDWARIMGAKTIILVGGGELFAALLPRVERLELTL 144

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           ++   +GDT FP  +   WE            ++ SY F    R+
Sbjct: 145 VEGNPKGDTFFPPIDWSQWEEEKRSGPLQGPNDTISYQFVDYHRK 189


>UniRef50_Q3BX85 Dihydrofolate reductase n=6 Tax=Xanthomonas RepID=Q3BX85_XANC5
          Length = 164

 Score =  175 bits (445), Expect = 3e-43,   Method: Composition-based stats.
 Identities = 68/162 (41%), Positives = 95/162 (58%), Gaps = 4/162 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LI A   +  IG +N +PW LP DL  FK  TL KP++MGR T +S+GR LPGR N++
Sbjct: 3   LTLIVAFDRNNAIGRDNELPWKLPDDLKRFKALTLGKPILMGRKTAQSLGRALPGRLNLV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           L+       D +  V SV++AI         E+ VIGGG VY   + +A  L +T +D  
Sbjct: 63  LTRSGQVPFDGMQAVASVEQAIERAVQEGAQELCVIGGGEVYRLTMERADLLAVTEVDTA 122

Query: 119 VEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           V+G DTHFP  +P  W     E H ADA+++H++ F   ERR
Sbjct: 123 VDGADTHFPPIDPAVWSPARRELHAADARHAHAFSFVDYERR 164


>UniRef50_Q5HFZ7 Dihydrofolate reductase n=54 Tax=Staphylococcus aureus
           RepID=DYR_STAAC
          Length = 159

 Score =  175 bits (445), Expect = 4e-43,   Method: Composition-based stats.
 Identities = 54/159 (33%), Positives = 91/159 (57%), Gaps = 4/159 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +S++ A  + RVIG EN +PW+LP DL   K+ +    ++MGR T+ESIG+PLP R+N++
Sbjct: 3   LSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVV 62

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+S    + + V  + S+++          + + GG  ++E+ + K   +Y+T I+ +  
Sbjct: 63  LTSDTSFNVEGVDVIHSIEDIYQL---PGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFR 119

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT FP Y  +DWE   S     D +N+  + F  L R+
Sbjct: 120 GDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK 158


>UniRef50_C9MLK6 Dihydrofolate reductase n=2 Tax=Prevotella RepID=C9MLK6_9BACT
          Length = 161

 Score =  175 bits (444), Expect = 5e-43,   Method: Composition-based stats.
 Identities = 55/160 (34%), Positives = 78/160 (48%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           +++IAA+A +R IG  N M + +  DL  FK+ T    VIMGR T+ S+ +  LP R+NI
Sbjct: 3   LNIIAAVAANRAIGYRNDMVYFIREDLKRFKQLTTGHTVIMGRKTFHSLPKGALPNRRNI 62

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI-DAEV 119
           +LS             S+DEA+       +  +IGG  +Y++ L  A +LYLT I D   
Sbjct: 63  VLSRTEKDFKGCEVYPSLDEAMRHIHADEQAFIIGGASLYKEALGIANRLYLTEIADTPA 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + D  FP Y    W     E H A       Y F    R+
Sbjct: 123 QADVFFPPYNDGTWRVESREEHPATDDTP-PYSFVNYVRK 161


>UniRef50_UPI00016B2267 dihydrofolate reductase n=1 Tax=candidate division TM7 single-cell
           isolate TM7c RepID=UPI00016B2267
          Length = 178

 Score =  175 bits (444), Expect = 5e-43,   Method: Composition-based stats.
 Identities = 65/162 (40%), Positives = 88/162 (54%), Gaps = 8/162 (4%)

Query: 3   SLIAALAVDRVIGMENAMPW--NLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           ++I A   +R IG    +PW  +LPADLA FK+ T    +IMG  T+ESIG RPL  RKN
Sbjct: 17  AIIVAYDRNRAIGRGGDLPWGRSLPADLAHFKQLTKGGGIIMGHRTFESIGSRPLLERKN 76

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL--PKAQKLYLTHIDA 117
           I++SS+P   + V  V  +  A+A         +IGG RVY   L  P+   +Y T IDA
Sbjct: 77  IVISSRPTDSEGVLTVMDLPSALALSHYST--FIIGGARVYADALETPEIDTIYATEIDA 134

Query: 118 EVEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              G DT FP+ +   W+      H ADA N + + F I +R
Sbjct: 135 SFPGADTFFPEIDMSIWQETSRIRHPADADNVYDFDFVIYKR 176


>UniRef50_Q1LSS4 Dihydrofolate reductase n=1 Tax=Baumannia cicadellinicola str. Hc
           (Homalodisca coagulata) RepID=Q1LSS4_BAUCH
          Length = 165

 Score =  174 bits (443), Expect = 6e-43,   Method: Composition-based stats.
 Identities = 81/160 (50%), Positives = 112/160 (70%), Gaps = 2/160 (1%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           +ISLIAA+ VDR+IG++N MPW+L  DL WFK++T NKPVIMGR T+++I +PL GR NI
Sbjct: 2   IISLIAAMTVDRIIGIKNTMPWHLYDDLIWFKKHTNNKPVIMGRKTFDAIKKPLSGRLNI 61

Query: 61  ILSSQ--PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +LS    P  D  + WV +  +A+ A G+V E+MVIGG ++Y  F+ +A +LYLTHID  
Sbjct: 62  VLSRNFIPSRDQDIIWVDNPIKALIAAGNVTEVMVIGGAQIYNIFILQAHRLYLTHIDIN 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           ++GDT FP Y  + W   F ++H+   +N   Y FEILER
Sbjct: 122 IKGDTWFPHYHTNQWRVTFRKYHNDQEKNLPRYYFEILER 161


>UniRef50_A5VJL0 Dihydrofolate reductase n=8 Tax=Lactobacillus RepID=A5VJL0_LACRD
          Length = 162

 Score =  174 bits (443), Expect = 6e-43,   Method: Composition-based stats.
 Identities = 58/158 (36%), Positives = 86/158 (54%), Gaps = 4/158 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           ++LI A  ++  IG +N +PW++ AD+  FK  T   P+IMGR T+ S+G +PLP R+NI
Sbjct: 4   LNLIWAEDLNGWIGKDNTIPWHVSADMKHFKTKTTGHPIIMGRRTFASLGNKPLPKRENI 63

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACG-DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L+S+    + V  V S+         +  E  VIGG  +Y+Q LP A KL  T I+ ++
Sbjct: 64  VLTSRNIDAEGVEVVHSLAALKEYLKANPNEYFVIGGATIYQQLLPMATKLTRTVINKQI 123

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
            GDT  P  + D W  V    ++ D Q      FE  E
Sbjct: 124 VGDTKMPTIDYDRWHLVNHNNYEKDDQ--LICRFEEWE 159


>UniRef50_Q0AN20 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria
           RepID=Q0AN20_MARMM
          Length = 173

 Score =  174 bits (443), Expect = 7e-43,   Method: Composition-based stats.
 Identities = 60/165 (36%), Positives = 92/165 (55%), Gaps = 8/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           + L+ A  ++ VIG++  +PW L +DL  FK  T  KP+IMGR TWES+  RPLPGR NI
Sbjct: 8   LVLVVARGMNGVIGVDGDLPWRLSSDLRNFKAITSGKPIIMGRKTWESLPRRPLPGRLNI 67

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAA------CGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           +++ Q G   +       + EA+ A         V E+ VIGG ++Y   L +A +LYLT
Sbjct: 68  VVTRQDGYVAEGGHVAGDLGEAMDAAFMRADADGVDEVCVIGGAQIYAATLERADRLYLT 127

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            ++A  EG+T  P+ +   W     E + A   + H++   +L+R
Sbjct: 128 EVEAAPEGETCLPEIDEALWRETRRELYPAGPGDDHAFMLRVLDR 172


>UniRef50_A6WGF8 Dihydrofolate reductase n=5 Tax=Actinomycetales RepID=A6WGF8_KINRD
          Length = 171

 Score =  174 bits (441), Expect = 9e-43,   Method: Composition-based stats.
 Identities = 60/162 (37%), Positives = 80/162 (49%), Gaps = 9/162 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           MI L+ A + + VIG    +PW +P DLA F   T    V+MGR TWES+    RPLPGR
Sbjct: 1   MIGLVWAQSRNGVIGAGGRIPWRVPEDLAHFSALTAGSTVVMGRATWESLPARFRPLPGR 60

Query: 58  KNIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +N++LS  PG   +    V  +  A+A      ++ VIGG  VY   L  A  L +T +D
Sbjct: 61  RNLVLSRDPGYAAEGAEVVHDLPGALA---GAGDVWVIGGSAVYRAALEHADVLVVTEVD 117

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             VEGDT  P+  P  WE V      A +     +      R
Sbjct: 118 LVVEGDTRAPEVGP-GWERVEVGDW-ATSTGGPRFRIGTWRR 157


>UniRef50_A0PY39 Dihydrofolate reductase n=3 Tax=Clostridium RepID=A0PY39_CLONN
          Length = 170

 Score =  174 bits (441), Expect = 1e-42,   Method: Composition-based stats.
 Identities = 60/163 (36%), Positives = 92/163 (56%), Gaps = 5/163 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL--NKPVIMGRHTWESIGRPLPGRK 58
           M+S++ A+  + VIG ++++PW+LP DL +FK+ TL  +K +IMGR T++S+   LPGRK
Sbjct: 1   MLSIVVAIGKNNVIGKDHSLPWHLPNDLKYFKKVTLTESKTMIMGRKTFQSLKALLPGRK 60

Query: 59  NIILSSQPGT---DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           +IIL+        D  V  +  +D       D  E  VIGGG ++   LP  +K+Y+T I
Sbjct: 61  HIILTKNKNFNMKDSNVEIINKIDMLKPIINDKKEYFVIGGGEIFSLLLPYTEKIYMTKI 120

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
                GDT FP+    DW +        D +N +++ F IL R
Sbjct: 121 HHNFIGDTFFPNINRYDWNTTKEIQGITDEKNVYNHTFLILNR 163


>UniRef50_A4VUL2 Dihydrofolate reductase n=9 Tax=Streptococcus RepID=A4VUL2_STRSY
          Length = 170

 Score =  174 bits (441), Expect = 1e-42,   Method: Composition-based stats.
 Identities = 50/164 (30%), Positives = 88/164 (53%), Gaps = 6/164 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           I  I A   + +IG  + +PW+LPADLA FK+ T    ++MGR T++ +G R LP R  I
Sbjct: 5   IVAIWAQDENGLIGKGDRLPWSLPADLAHFKKTTTGHTMVMGRITFDGMGKRALPNRHTI 64

Query: 61  ILSSQPGTD---DRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHID 116
           +L++        +R+T + SV++ +       + + VIGGG+++  F P  + L +T I 
Sbjct: 65  VLTTDKTYQLESERITILHSVEDVLDWYNKQEQTLFVIGGGQIFTAFAPYIETLIVTDIH 124

Query: 117 AEVEGDTHFPD-YEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +  GD +FP  +  + ++   +     D +N + +  +  ERR
Sbjct: 125 GQFNGDVYFPKAFPMEKFQLQSANLRPKDEKNPYDFTIKTYERR 168


>UniRef50_A0Z2N0 Dihydrofolate reductase n=2 Tax=unclassified Gammaproteobacteria
           (miscellaneous) RepID=A0Z2N0_9GAMM
          Length = 184

 Score =  173 bits (440), Expect = 1e-42,   Method: Composition-based stats.
 Identities = 59/164 (35%), Positives = 88/164 (53%), Gaps = 7/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + L+ A++ + VIG  NA+PW+LP DL  FK+ T+  P++MGR T+ES+GRPLPGR N++
Sbjct: 13  VVLVLAVSENGVIGRGNALPWDLPDDLQHFKKATMGCPILMGRKTFESVGRPLPGRTNLV 72

Query: 62  LSSQPGT-DDRVTWVKSVDE------AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           L+         VT   SVD+      A A       + V+GG  +Y   LP+A ++ LT 
Sbjct: 73  LTRDSTWQAPGVTIFSSVDKALALAEAQALIDGASAVCVVGGAEIYRLCLPRADRILLTL 132

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +  +V GD  F     + W+    E     A+NSH +      R
Sbjct: 133 VHGDVSGDATFDLSVLETWQEQRREHFPKGARNSHDFSVVEFVR 176


>UniRef50_C8WCM1 Dihydrofolate reductase region n=4 Tax=Zymomonas mobilis
           RepID=C8WCM1_ZYMMN
          Length = 165

 Score =  173 bits (439), Expect = 2e-42,   Method: Composition-based stats.
 Identities = 57/160 (35%), Positives = 86/160 (53%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I LI A A + VIG +N MPW++ ADL  FK  TL  P+IMGR T+ES+   LP R +I+
Sbjct: 7   IMLIFARAQNGVIGKDNTMPWHISADLKHFKALTLGHPMIMGRRTFESLPGLLPKRPHIV 66

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           L+       +    V  ++EAI A      +I VIGG  +++QF  KA ++ LT I  + 
Sbjct: 67  LTHNHHWQAEGAEVVCDLEEAIKAARKYSSQIAVIGGANIFQQFWDKADRIELTEIYRDY 126

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            GDT     + + +  V  E   A+ +   ++ F+   R+
Sbjct: 127 SGDTFVDLPDMNHFSLVGQEDFKAEGECP-AFSFKSFLRK 165


>UniRef50_A1SJ32 Dihydrofolate reductase n=1 Tax=Nocardioides sp. JS614
           RepID=A1SJ32_NOCSJ
          Length = 160

 Score =  173 bits (439), Expect = 2e-42,   Method: Composition-based stats.
 Identities = 54/144 (37%), Positives = 81/144 (56%), Gaps = 2/144 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + L+AA+A + VIG    +PW LP +   FK  T    ++MGR T++SIGRPLPGR  I+
Sbjct: 8   VVLVAAVARNGVIGDGPDIPWQLPGEQRLFKGLTWGHILVMGRATYDSIGRPLPGRTTIV 67

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           L+  P    + V     +  A+A    +  E+MV GGG+VY   LP A +  L+ +D E 
Sbjct: 68  LTRSPDWSAEGVHVAHDLPAALALADTLEGEVMVAGGGQVYAAALPVADEQVLSEVDLEP 127

Query: 120 EGDTHFPDYEPDDWESVFSEFHDA 143
           +GD  +P+++  +W     E HD 
Sbjct: 128 QGDAFYPEFDRSEWRETAREQHDG 151


>UniRef50_B9XJM4 Dihydrofolate reductase n=1 Tax=bacterium Ellin514
           RepID=B9XJM4_9BACT
          Length = 156

 Score =  173 bits (438), Expect = 2e-42,   Method: Composition-based stats.
 Identities = 58/128 (45%), Positives = 78/128 (60%), Gaps = 1/128 (0%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
              IAA++ +RVIG  N +PW+LP D  WFK+ T  + V+MGR T+ESIGRPLP R+ I+
Sbjct: 4   FKAIAAMSQNRVIGQGNKIPWHLPEDFKWFKKMTTGQVVVMGRKTFESIGRPLPNRETIV 63

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           LS  P     V  +  + E I+   +  EI + GG ++YEQ LP    LYLT +   VEG
Sbjct: 64  LSRGPFQHPGVRTIFDLSE-ISLADESREIFICGGAQIYEQTLPMCSDLYLTVLKRTVEG 122

Query: 122 DTHFPDYE 129
           D  FP +E
Sbjct: 123 DAFFPTFE 130


>UniRef50_Q0SWS9 Dihydrofolate reductase n=1 Tax=Clostridium perfringens SM101
           RepID=Q0SWS9_CLOPS
          Length = 161

 Score =  172 bits (437), Expect = 3e-42,   Method: Composition-based stats.
 Identities = 57/161 (35%), Positives = 93/161 (57%), Gaps = 6/161 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M S+I A +++ +IG+ N +PWN+P+DL  FK  T+ K ++MGR T+ES+   LPGR ++
Sbjct: 1   MFSIIVAKSINNIIGVNNKIPWNIPSDLKRFKELTMGKKILMGRKTFESLPFVLPGRTHL 60

Query: 61  ILSSQPGT---DDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +L+++         V     +D+ I+   D   EI VIGGG++Y +FL  A KLY+T + 
Sbjct: 61  VLTTKKDFSYNHKDVIIYNDLDKLISEYKDSMEEIFVIGGGKIYSEFLKYASKLYITEVL 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
            E +GDT+FP  +   W   +        +N+  + + I E
Sbjct: 121 KEYKGDTYFPKVDYSKWIKTYE--SSIYEENATKFKYVIYE 159


>UniRef50_D1PCZ0 Dihydrofolate reductase n=1 Tax=Prevotella copri DSM 18205
           RepID=D1PCZ0_9BACT
          Length = 179

 Score =  172 bits (436), Expect = 4e-42,   Method: Composition-based stats.
 Identities = 59/181 (32%), Positives = 90/181 (49%), Gaps = 25/181 (13%)

Query: 1   MISLIAALAV-DRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRK 58
           M+S+IA ++   R IG +N + + +P+D+  F+  T    +IMGR T+ES+    LP R+
Sbjct: 1   MLSIIACISKVHRAIGYKNRLLYAIPSDMTRFRMLTTGHTIIMGRKTFESLPNGALPNRR 60

Query: 59  NIILSSQPGTDDRVTWVKSVDEAIAACGDV-------------------PEIMVIGGGRV 99
           NI++S             S++EA+AA  +                     E  +IGG  +
Sbjct: 61  NIVISKTREQITGCEVYTSLEEALAARKEEAARKEEVGNKETVGSKEASDECFIIGGASI 120

Query: 100 YEQFLPKAQKLYLTHIDAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           YEQ LP A KLYLT ++ E E  DT FP+  P +WE    E  +   +N   + F  L R
Sbjct: 121 YEQALPFADKLYLTIVEKEPEHADTFFPEINPAEWEVTEKEMRN---ENGLPFTFLTLYR 177

Query: 159 R 159
           +
Sbjct: 178 K 178


>UniRef50_C7NFY1 Dihydrofolate reductase n=3 Tax=Actinomycetales RepID=C7NFY1_KYTSD
          Length = 337

 Score =  171 bits (435), Expect = 5e-42,   Method: Composition-based stats.
 Identities = 54/177 (30%), Positives = 82/177 (46%), Gaps = 28/177 (15%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++L+ A+A +  IG +  +PW+LP DL  FK  T+   ++MGR T+ES  RPLPGR++++
Sbjct: 168 LTLVVAVARNGAIGRDGDLPWHLPGDLKHFKDTTMGGTMVMGRRTFESFPRPLPGRRHVV 227

Query: 62  LSSQPGTDDR----------------VTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLP 105
           ++S P                     V   +S  EA+   GD  E+ V+GG  V+   LP
Sbjct: 228 MTSDPTWLPGGPAVEGDPASGARFDEVLVARSWAEALLMAGDG-EVFVVGGAGVFADALP 286

Query: 106 KAQKLYLTHIDAEV-EGDTHFP---DYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            A +L LT +D    + DT FP     +P  W        +        Y      R
Sbjct: 287 VADRLVLTEVDQSPQDADTFFPITWPVDPTVWHESSRTPGEG-------YAIVEYRR 336


>UniRef50_Q5V600 Dihydrofolate reductase 2 n=1 Tax=Haloarcula marismortui
           RepID=DYR2_HALMA
          Length = 167

 Score =  171 bits (434), Expect = 6e-42,   Method: Composition-based stats.
 Identities = 68/164 (41%), Positives = 86/164 (52%), Gaps = 14/164 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR----PLPGR 57
           +SLIAA+A + VIG    +PW  P DL  FK  T+  PVIMGR T+ESI R    PLP R
Sbjct: 5   LSLIAAVAANGVIGAGGDIPWQYPEDLTHFKETTVGHPVIMGRRTFESIRRDLDGPLPER 64

Query: 58  KNIILSSQP-GTDDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTH 114
            NI+L++ P    D VT V S   A+A   D       VIGG  VYEQFLP+A +L LT 
Sbjct: 65  LNIVLTTTPHQLPDSVTAVTSTTAAVAEAADSDASTTYVIGGATVYEQFLPQADELILTE 124

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + A  +GDT FP  +  +W  +    H         +      R
Sbjct: 125 LAAAFDGDTVFPTVDWSNWTEMERTTHSE-------FAIVRYTR 161


>UniRef50_A0JZC8 Dihydrofolate reductase n=11 Tax=Bacteria RepID=A0JZC8_ARTS2
          Length = 194

 Score =  171 bits (434), Expect = 7e-42,   Method: Composition-based stats.
 Identities = 60/170 (35%), Positives = 84/170 (49%), Gaps = 14/170 (8%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           + L+ A     VIG +  MPW+LP D+  F R T   PVIMGR TW S     RPLPGR 
Sbjct: 23  VGLVWAQTTAGVIGKDGDMPWHLPEDMKHFTRLTTGHPVIMGRKTWLSFPDKYRPLPGRT 82

Query: 59  NIILSSQPGTDD-----RVTWVKSVDEAI---AACGDVPEIMVIGGGRVYEQFLPKAQKL 110
           NI+++ Q G  D         VKS+D+A+           + V+GGG ++ Q L  A   
Sbjct: 83  NIVVTRQEGWGDTPDARGAIAVKSLDDALLESQFAPGHETVWVLGGGEIFAQTLDIADVA 142

Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEF--HDADAQNSHSYCFEILER 158
            +T ID+E +GDT+ P+    +W+   SE       +     Y F +  R
Sbjct: 143 VVTFIDSETDGDTYAPELGY-EWKLAASEPATGWLTSATGTRYRFTMWRR 191


>UniRef50_B8HHJ9 Dihydrofolate reductase n=2 Tax=Micrococcineae RepID=B8HHJ9_ARTCA
          Length = 181

 Score =  171 bits (433), Expect = 9e-42,   Method: Composition-based stats.
 Identities = 63/169 (37%), Positives = 90/169 (53%), Gaps = 12/169 (7%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           +I +I A A + VIG +  MPW+LP D   F+R T    VIMGR TWES+    RPLPGR
Sbjct: 7   VIGMIWAQASNGVIGRDGTMPWHLPEDFEHFRRTTEGHSVIMGRRTWESLPEPFRPLPGR 66

Query: 58  KNIILSSQP-GTDDRVTWVKSVDEAIAACGDV---PEIMVIGGGRVYEQ--FLPKAQKLY 111
           +N++++S P  +        S+  A+AA        ++ +IGGG VY +  FL  A    
Sbjct: 67  RNLVITSDPAWSAPGAVRSSSILNALAAAAGQPGSDQVWIIGGGMVYREALFLRAANTAV 126

Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEF--HDADAQNSHSYCFEILER 158
           +T I ++++GDT+ P+  PD WE   +E       A N   Y  E   R
Sbjct: 127 ITLIASDIDGDTYAPELGPD-WEMASAEPGVGWTTAANGTRYRIETWTR 174


>UniRef50_C6XGC7 Dihydrofolate reductase protein n=1 Tax=Candidatus Liberibacter
           asiaticus str. psy62 RepID=C6XGC7_LIBAP
          Length = 176

 Score =  170 bits (432), Expect = 1e-41,   Method: Composition-based stats.
 Identities = 58/164 (35%), Positives = 85/164 (51%), Gaps = 7/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I LIAA+  + VIG    MPW + +DL  FK  T   PV+MG  T++SIGR LPGR NII
Sbjct: 6   IILIAAITRNNVIGSCGGMPWKISSDLKRFKSLTTGNPVVMGYRTFQSIGRLLPGRTNII 65

Query: 62  LSSQ----PGTDDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           ++         +       S+ +++         +I +IGGG +Y Q +  A  LY+THI
Sbjct: 66  ITRDNTRRASVNPEAVLASSILDSLDLASKTGSKKIFIIGGGEIYAQTISLAHTLYITHI 125

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFH-DADAQNSHSYCFEILER 158
           + E+EGD  FP  + + W+    E    A   + +   F I +R
Sbjct: 126 EKEIEGDVFFPSIDSNIWKKQEKEIITSAGEGDDYPTRFVIYDR 169


>UniRef50_Q0TV23 Dihydrofolate reductase n=8 Tax=Clostridium perfringens
           RepID=Q0TV23_CLOP1
          Length = 161

 Score =  169 bits (430), Expect = 2e-41,   Method: Composition-based stats.
 Identities = 54/162 (33%), Positives = 91/162 (56%), Gaps = 6/162 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M S+I A +++ +IG+ N MPWN+P+DL  FK  T+ K ++MGR T+ES+   LPGR ++
Sbjct: 1   MFSIIVAKSINNIIGVNNKMPWNIPSDLKRFKELTMGKKILMGRKTFESLPFVLPGRTHL 60

Query: 61  ILSSQPGT---DDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +L+++         V     +++ I+   D   EI VIGGG++Y + L    KLY+T + 
Sbjct: 61  VLTTKKDFSYNHKDVIIYNDLNKLISEYKDSMEEIFVIGGGKIYSELLKYTSKLYITEVL 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            E +GDT+FP  +   W   +        +N + + F   ++
Sbjct: 121 KEYKGDTYFPKVDYYKWIKTYE--SSIHEENGNKFKFFNYKK 160


>UniRef50_D1PWR8 Dihydrofolate reductase n=1 Tax=Prevotella bergensis DSM 17361
           RepID=D1PWR8_9BACT
          Length = 163

 Score =  169 bits (430), Expect = 2e-41,   Method: Composition-based stats.
 Identities = 51/142 (35%), Positives = 79/142 (55%), Gaps = 2/142 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           IS+I A+A +R IG  N + ++LP D+  FK  T    +IMGRHT++S+    L  R+NI
Sbjct: 3   ISIIVAMARNRAIGFRNHLLYHLPDDMKHFKALTTGHTIIMGRHTFDSLPNGALLHRRNI 62

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119
           ++S             S+++AIA+C    E+ +IGG  +Y Q L  A ++YLT +D    
Sbjct: 63  VVSRSRTHIVGCEVFGSLEQAIASCRGEQEVFIIGGESIYRQALAVAHRIYLTLVDDTPT 122

Query: 120 EGDTHFPDYEPDDWESVFSEFH 141
           + DT FP+ +   W+    E H
Sbjct: 123 QFDTVFPEIDMSHWQETKKEKH 144


>UniRef50_A7SCT0 Predicted protein n=2 Tax=Nematostella vectensis RepID=A7SCT0_NEMVE
          Length = 187

 Score =  169 bits (429), Expect = 2e-41,   Method: Composition-based stats.
 Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 21/178 (11%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT-------LNKPVIMGRHTWESIG--- 51
            S I A+ + R IG  N +PW +  D+ +F   T           VIMGR  WESI    
Sbjct: 8   FSCIVAMDLKRGIGKNNDLPWKIKGDMKFFTEKTSEVKTEGKQNAVIMGRKVWESIPEKF 67

Query: 52  RPLPGRKNIILSSQPGTDD-RVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFL 104
           RPL GR NI+LS             +S ++A+           +  + V GG  +Y+  +
Sbjct: 68  RPLKGRLNIVLSRTLSEPPQGAQLCRSFEQALTILSTDPYTKKIENVFVCGGSALYKDAM 127

Query: 105 PK--AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHD--ADAQNSHSYCFEILER 158
                 ++Y+T+ID E + D  FP+++ + +  V           +    Y F + +R
Sbjct: 128 AHSACTRIYITYIDQEFDCDVFFPEFDQNTYHLVEDPDVPSVQHEEKGIKYKFCVYDR 185


>UniRef50_C2MBL2 Dihydrofolate reductase n=1 Tax=Porphyromonas uenonis 60-3
           RepID=C2MBL2_9PORP
          Length = 173

 Score =  169 bits (429), Expect = 2e-41,   Method: Composition-based stats.
 Identities = 60/163 (36%), Positives = 86/163 (52%), Gaps = 6/163 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           I +I A A DR IG +  MPW L  DL   K  T    VIMGRHTW+SIG RPLP R NI
Sbjct: 3   IWIIVATARDRAIGRDGTMPWRLKDDLRRLKATTTGHAVIMGRHTWDSIGARPLPNRYNI 62

Query: 61  ILSSQ--PGTDDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++S     G  +      ++++A+  C       + ++GGG +Y+  LP A  L LT +D
Sbjct: 63  VVSRTLPEGDAETHYVASTLEQALQHCQQAGYDRVYIMGGGVLYKSGLPYATHLNLTMVD 122

Query: 117 AEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             V + DTHFP+    +W  +    + AD +N +     + +R
Sbjct: 123 TVVPDADTHFPEINLSEWSKLEEAHYPADERNDYPVTQTLYKR 165


>UniRef50_D0VXF2 Putative uncharacterized protein dfrP n=1 Tax=Bacillus phage
           phiNIT1 RepID=D0VXF2_9VIRU
          Length = 168

 Score =  169 bits (429), Expect = 3e-41,   Method: Composition-based stats.
 Identities = 56/161 (34%), Positives = 91/161 (56%), Gaps = 5/161 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LIAA+ ++  IG +N + W++  D+ WF++ T NK V+MGR T+ESIG+PL GR N++
Sbjct: 3   VALIAAMGLNLEIGADNRLLWDIKEDMNWFRQKTKNKVVVMGRKTYESIGKPLKGRVNVV 62

Query: 62  LSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           L+     D    V    ++++      +  EIMVIGG  +Y QF P A ++YLT ++   
Sbjct: 63  LTHNKEYDPHPDVLVRHNLEDIFFEFRNELEIMVIGGETIYNQFFPYANRIYLTQVEKTY 122

Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            E D  FP+++   W   F  + D        Y F + ++R
Sbjct: 123 EEADAFFPEFDCSIWNRYF--YQDGSEDIGIKYNFSVYKKR 161


>UniRef50_Q14P23 Putative dihydrofolate reductase oxidoreductase protein n=1
           Tax=Spiroplasma citri RepID=Q14P23_SPICI
          Length = 160

 Score =  169 bits (428), Expect = 4e-41,   Method: Composition-based stats.
 Identities = 45/164 (27%), Positives = 81/164 (49%), Gaps = 12/164 (7%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI L+ A+  + +IG  + +PW+L  +L  FK  TL + ++ GR T+E IG PLP RK +
Sbjct: 1   MIKLLWAMDENNLIGQNDQLPWHLREELQHFKETTLGQTILFGRLTYEGIGWPLPKRKTL 60

Query: 61  ILSSQPGT---DDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           +L+           V  V  +   I         +I + GG ++YE  LP A +L ++ I
Sbjct: 61  VLTRHLDYQIKHPDVEVVTDLTAIINFYHQNPTEDIYICGGKKIYEATLPYADELIISLI 120

Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
             + +GDT+FP ++ + +  +    +         +  +  +R+
Sbjct: 121 KGKYQGDTYFPSFDLNQFTLIKLNEYQQ-------FVIKYYKRK 157


>UniRef50_B7H0P5 Dihydrofolate reductase type 3(Dihydrofolate reductasetype III)
           n=19 Tax=Acinetobacter RepID=B7H0P5_ACIB3
          Length = 181

 Score =  168 bits (427), Expect = 4e-41,   Method: Composition-based stats.
 Identities = 55/160 (34%), Positives = 87/160 (54%), Gaps = 9/160 (5%)

Query: 5   IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64
           + A+  +  IG  NA+PW++ ADL  FK  T    VIMGR T ES+GR LP R N +++ 
Sbjct: 11  VVAMDKNHCIGKGNALPWHISADLKHFKEITQGGVVIMGRKTLESMGRALPNRVNWVITR 70

Query: 65  QPGTD-DRVTWVKSVDEAIAACGDVPE------IMVIGGGRVYEQFLPKAQKLYLTHIDA 117
                 D V    S+++A+ A  +  +      + +IGGG +++Q L  A +L LTH+D 
Sbjct: 71  DINWHFDGVKIAYSIEDALNAALEDAKNTEKQALFIIGGGEIFKQTLSIADRLELTHVDL 130

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
           +V+GD H+P   P ++    SE    D ++  S+ F   +
Sbjct: 131 DVQGDAHYPTI-PSEFHKTASEQ-QVDEKSGTSFEFATYK 168


>UniRef50_C7H0N2 Dihydrofolate reductase n=1 Tax=Eubacterium saphenum ATCC 49989
           RepID=C7H0N2_9FIRM
          Length = 162

 Score =  168 bits (427), Expect = 4e-41,   Method: Composition-based stats.
 Identities = 49/162 (30%), Positives = 79/162 (48%), Gaps = 6/162 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59
           ++ I  +  +  IG +  +  +L  DL +FK  T+ K +I+GR T ES    +PLPGRK 
Sbjct: 1   MNAIVVVDKNWCIGKDGGLLVHLSKDLKYFKEKTIGKTLIVGRKTLESFPGGKPLPGRKT 60

Query: 60  IILSSQPGT-DDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+L+       +      S  E +    D+   ++ V GGG +Y+QFL    K ++T I 
Sbjct: 61  IVLTRNTSYKAEGAYVCHSKQEVLEKVKDLHPADVFVAGGGAIYKQFLNDVDKGFVTKIC 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            E  GDT FP+ + D+ +       +   +N   + F I  R
Sbjct: 121 NEYSGDTFFPNLDEDE-DFALESEGETIEENGVKFKFCIYNR 161


>UniRef50_Q54801 Dihydrofolate reductase n=65 Tax=Streptococcus RepID=DYR_STRPN
          Length = 168

 Score =  168 bits (427), Expect = 4e-41,   Method: Composition-based stats.
 Identities = 57/162 (35%), Positives = 94/162 (58%), Gaps = 4/162 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           I  I A   + VIG EN +PW+LPA+L  FK  TLN  ++MGR T++ +G R LP R+ +
Sbjct: 5   IVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPKRETL 64

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           IL+  P    D V   + V   +       + + +IGG ++++ F P   ++ +THI A 
Sbjct: 65  ILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHAR 124

Query: 119 VEGDTHFP-DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           VEGDT+FP + +   +E+V S+F+  D +N + +  +  +R+
Sbjct: 125 VEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRK 166


>UniRef50_Q18HG9 Dihydrofolate reductase n=4 Tax=Halobacteriaceae RepID=Q18HG9_HALWD
          Length = 195

 Score =  168 bits (427), Expect = 5e-41,   Method: Composition-based stats.
 Identities = 66/164 (40%), Positives = 89/164 (54%), Gaps = 18/164 (10%)

Query: 6   AALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNII 61
           AA+A + +IG +  MPW++PADL  FKR T+  PVI+GR T+E+I    G P PGR +I+
Sbjct: 37  AAVAANDIIGRDGEMPWHIPADLQQFKRRTMGHPVILGRRTYEAIIGALGEPFPGRTSIV 96

Query: 62  LSSQP-GTDDRVTWVKSVDEAIAACGDVPE------IMVIGGGRVYEQFLPKAQKLYLTH 114
           LSSQ       V  V S+  AI              + V GGG VYEQFLP A +L LT 
Sbjct: 97  LSSQSRDVPADVILVHSITSAIREASKNARERGVGTVYVAGGGGVYEQFLPLADRLRLTE 156

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +  E EGDT FP ++   W+    E ++       ++ F   ER
Sbjct: 157 LHDEYEGDTKFPSWDDTVWQETTREKNE-------TFDFVTYER 193


>UniRef50_Q5M5B2 Dihydrofolate reductase n=9 Tax=Streptococcus RepID=Q5M5B2_STRT2
          Length = 167

 Score =  168 bits (427), Expect = 5e-41,   Method: Composition-based stats.
 Identities = 56/160 (35%), Positives = 90/160 (56%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKNI 60
           I  I A A + VIG  + MPW+LPA+LA FK+ T+   ++MGR T++ + R  LPGR+ +
Sbjct: 5   IIAIWAEARNHVIGKNHTMPWHLPAELAHFKKTTMGSAILMGRVTFDGMNRRCLPGRETL 64

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           IL+     D + VT V SV+EA+A       ++ + GG  VY+ F      L  T I+A+
Sbjct: 65  ILTRDKDFDCEEVTTVTSVEEALAWFEQQDKDLYIAGGASVYKAFDGHYDVLIKTTIEAD 124

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +EGDT+FP  +   ++ V       + +N++ +     E+
Sbjct: 125 LEGDTYFPQLDTTAFKEVSRNRVPKNEKNAYDFSISRYEK 164


>UniRef50_C3RMT4 Dihydrofolate reductase n=4 Tax=Bacteria RepID=C3RMT4_9MOLU
          Length = 156

 Score =  167 bits (425), Expect = 7e-41,   Method: Composition-based stats.
 Identities = 58/162 (35%), Positives = 95/162 (58%), Gaps = 11/162 (6%)

Query: 1   MISLIAALAVDRVIGME---NAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGR 57
           MI++I A   D +IG +   N MPWN+P DL  FK  TLNK ++MG  T+++IGRPLP R
Sbjct: 1   MINIIVATDEDLLIGKKDSRNGMPWNVPEDLQHFKATTLNKTILMGLTTYQAIGRPLPNR 60

Query: 58  KNIILSSQPGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           K I++S +P  D+RV    S++E I        ++ + GG  +Y+Q LP A +L ++ I 
Sbjct: 61  KTIVVSFEPFEDERVEVRSSLEEVIEEYRSSGEDLFISGGASIYKQCLPIADQLLISRIP 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            + EG+T+FP+++   ++ V  +  +       ++  E  +R
Sbjct: 121 GKHEGETYFPNFDEYGYKLVAQKPFE-------TFTLETYKR 155


>UniRef50_Q59408 Dihydrofolate reductase type A13 n=57 Tax=Bacteria
           RepID=DYR13_ECOLX
          Length = 165

 Score =  167 bits (425), Expect = 8e-41,   Method: Composition-based stats.
 Identities = 55/160 (34%), Positives = 81/160 (50%), Gaps = 6/160 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I L+AA+  +RVIG    +PW +P +   F+R T +K V+MGR T+ESIG+PLP R  ++
Sbjct: 8   IYLVAAMGANRVIGNGPDIPWKIPGEQKIFRRLTESKVVVMGRKTFESIGKPLPNRHTVV 67

Query: 62  LSSQPGT-DDRVTWVKSVDEAI-AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           LS Q G        V ++     +      E+ V  G  VY   LP A  ++L+ +    
Sbjct: 68  LSRQAGYSAPGCAVVSTLSHVSPSTAEHGKELYVARGAEVYALALPHANGVFLSEVHQTF 127

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           EGD  FP     ++E V SE      Q + +Y   +  RR
Sbjct: 128 EGDAFFPVLNAAEFEVVSSE----TIQGTITYTHSVYARR 163


>UniRef50_Q9U8B8 Dihydrofolate reductase n=1 Tax=Heliothis virescens RepID=DYR_HELVI
          Length = 185

 Score =  167 bits (424), Expect = 9e-41,   Method: Composition-based stats.
 Identities = 54/179 (30%), Positives = 82/179 (45%), Gaps = 22/179 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT-------LNKPVIMGRHTWESIG--- 51
           ++LIAA   +  IG+  A+PW L  ++A+F   T           VIMGR TW+ I    
Sbjct: 6   LNLIAAACDNMGIGVNGALPWRLKKEMAYFTTMTSKVSEPTKVNAVIMGRRTWDCIPDKY 65

Query: 52  RPLPGRKNIILSSQPGT-----DDRVTWVKSVDEAIAACGDVPEI---MVIGGGRVYEQF 103
           RPL  R NI+L+    +      + V     +DEAI       +I    VIGG  +Y   
Sbjct: 66  RPLQDRVNIVLTHNVDSVKENVPEGVMVFPGLDEAIKYIEGREDIESTWVIGGSSIYRAA 125

Query: 104 L--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSE--FHDADAQNSHSYCFEILER 158
           +  P   K+YLT I    + DT FP+ +   +  V  E    +   + + SY F + ++
Sbjct: 126 MTHPNCGKIYLTEIQKSFDCDTFFPNIDKQQFHLVDEEQIPGEKQVEGNISYYFRVYKK 184


>UniRef50_P00380 Dihydrofolate reductase n=1 Tax=Enterococcus faecium
           RepID=DYR_ENTFC
          Length = 167

 Score =  167 bits (424), Expect = 1e-40,   Method: Composition-based stats.
 Identities = 49/162 (30%), Positives = 91/162 (56%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKN 59
           M   + A   + +IG +  +PW LP D+ +F+ +T++K ++MGR T+E +G+  LP R  
Sbjct: 1   MFISMWAQDKNGLIGKDGLLPWRLPNDMRFFREHTMDKILVMGRKTYEGMGKLSLPYRHI 60

Query: 60  IILSSQPGT--DDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+L++Q     +     + S+DE +A   D+  +I V GG R+++  LP+ + ++ T ID
Sbjct: 61  IVLTTQKDFKVEKNAEVLHSIDELLAYAKDIPEDIYVSGGSRIFQALLPETKIIWRTLID 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           AE EGDT   + +   +E V       + +N + + F+  ++
Sbjct: 121 AEFEGDTFIGEIDFTSFELVEEHEGIVNQENQYPHRFQKWQK 162


>UniRef50_C3XD45 Dihydrofolate reductase n=2 Tax=Oxalobacter formigenes
           RepID=C3XD45_OXAFO
          Length = 163

 Score =  167 bits (423), Expect = 1e-40,   Method: Composition-based stats.
 Identities = 55/160 (34%), Positives = 88/160 (55%), Gaps = 7/160 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS + A+A +RVIG +  MPW++P +   F+  T+ K +I+GR T ESIGR LP R  II
Sbjct: 4   ISHVVAMAENRVIGKDGQMPWHIPGEQKIFRELTVGKALILGRKTHESIGRVLPDRITII 63

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +S +   +      V  +DEAI    +    +I++ GGG ++ Q LP   K+YL+ + A+
Sbjct: 64  VSRKKDYEVPGAHVVHDIDEAIRLAREFGKEDIVIGGGGELFSQTLPVTDKVYLSIVHAD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            +G+T +P+   +++     +  DA       Y F   ER
Sbjct: 124 FDGETFYPELPKEEFVEKARKEIDAS----IPYAFVEFER 159


>UniRef50_D2LGH8 Dihydrofolate reductase n=1 Tax=Rhodomicrobium vannielii ATCC 17100
           RepID=D2LGH8_RHOVA
          Length = 178

 Score =  167 bits (423), Expect = 1e-40,   Method: Composition-based stats.
 Identities = 54/166 (32%), Positives = 86/166 (51%), Gaps = 9/166 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++L+ A A + VIG E  +PW L +DL  F+R T+  P+IMGR T+ SIG+PL GR ++I
Sbjct: 9   LALVVAAAENDVIGREGKLPWRLKSDLKRFRRLTMGHPLIMGRKTFASIGKPLDGRDSVI 68

Query: 62  LSSQP---GTDDRVTWVKSVDEAIA------ACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112
           ++           V    S+ +A+       A   V E  VIGG  ++   LP A +++L
Sbjct: 69  VTRDAASVSPQPGVFVATSIKDALDIARARAAERRVAEAFVIGGAEIFALALPYADRIHL 128

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             + A   GD ++     ++W+ V  E   A+  +  S    +LER
Sbjct: 129 ARVHASPSGDAYWQAPPAEEWQVVSREEWPANQTDEFSVTDLVLER 174


>UniRef50_D0J8Z9 Dihydrofolate reductase n=2 Tax=Blattabacterium RepID=D0J8Z9_BLASP
          Length = 173

 Score =  166 bits (422), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 57/172 (33%), Positives = 86/172 (50%), Gaps = 16/172 (9%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I LI+A++ + VIG  N + W+LP DL  FK  T  + V+MGR T+ESIG+ LPGR+NII
Sbjct: 3   IILISAVSSNGVIGKNNQLMWHLPNDLKRFKNMTFGETVLMGRKTFESIGKILPGRRNII 62

Query: 62  LSSQPGTD--------------DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKA 107
           L+ +                         S+ +      +  +I VIGG ++Y   + KA
Sbjct: 63  LTKKNKIHFFSSTNTNNKTNPRGTFEVYSSLKQIYDL--NYKKIFVIGGEKIYTSTIDKA 120

Query: 108 QKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
             + LT I  +  GD  FP      W+  +  FH+ D  + ++Y F   ER+
Sbjct: 121 HIIELTVIHKKFYGDAKFPKIPLSKWKKTYEFFHEKDKHHLYNYSFIRYERK 172


>UniRef50_B1MYC2 Dihydrofolate reductase n=3 Tax=Leuconostoc RepID=B1MYC2_LEUCK
          Length = 166

 Score =  166 bits (421), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 56/162 (34%), Positives = 86/162 (53%), Gaps = 4/162 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I ++ A      IG    + W+LP DL  FK  T+N  ++MGR TW++IGRPLPGR +++
Sbjct: 4   IRMVWAEDSTHAIGKNGQLAWHLPDDLKLFKAETMNTLMVMGRTTWDTIGRPLPGRTSLV 63

Query: 62  LSSQPGTD---DRVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           L+ Q       D V    SVDE +     +  +I + GG  +Y  F+P A  L +T ID 
Sbjct: 64  LTHQKDFKTPYDDVIIAHSVDEVLDYIEKETRDISIAGGAAIYHAFMPYATDLIVTRIDV 123

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + GDT     +   ++ V +  HD D ++ +S+  E  ER+
Sbjct: 124 TIAGDTFVDAIDLSQFKLVSATAHDKDDKHDYSFVVERYERQ 165


>UniRef50_Q1GFV5 Dihydrofolate reductase n=18 Tax=Rhodobacterales RepID=Q1GFV5_SILST
          Length = 163

 Score =  166 bits (421), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 56/139 (40%), Positives = 83/139 (59%), Gaps = 6/139 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MI+LI A A +  IG +N +PW+ P DL  F+R TL   +IMGR+TW+S+  +PL  R N
Sbjct: 1   MITLIVARARNGAIGKDNDIPWHAPEDLKAFQRETLGGAIIMGRNTWDSLPFKPLKNRFN 60

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           I++SS P   D  T V S+DEAI          +  IGG  +Y+  L +A +L +T +D 
Sbjct: 61  IVVSSNPDAAD--TVVASLDEAIDLARSEGYARLYGIGGAGIYKGMLARADRLMITEVDL 118

Query: 118 EV-EGDTHFPDYEPDDWES 135
           E+ + D  FP++ P++W  
Sbjct: 119 EIDDADAFFPEFPPEEWRV 137


>UniRef50_UPI0001874368 dihydrofolate reductase n=1 Tax=Corynebacterium amycolatum SK46
           RepID=UPI0001874368
          Length = 176

 Score =  166 bits (421), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 58/160 (36%), Positives = 77/160 (48%), Gaps = 4/160 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           + +I A +   +IG    MPW+LP DL  FK  T+  PVIMGR TW+S+    RPLPGR+
Sbjct: 15  VGMIWAQSRAGIIGDGATMPWHLPEDLQHFKTTTMGAPVIMGRRTWDSLNPKFRPLPGRR 74

Query: 59  NIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           NI+LS             S++ A+AA  D P   +IGGGRVY   L  A +  +T ID +
Sbjct: 75  NIVLSRSVSDFPGAESATSLEAALAAVADEPAAWIIGGGRVYRDALSLADECVVTDIDTD 134

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           V         +  DW  V              Y F   +R
Sbjct: 135 VSVPVPVMAPDLYDWVRVEDGPWQTSTT-GLRYRFCTWQR 173


>UniRef50_C2HC06 Dihydrofolate reductase n=11 Tax=Enterococcus faecium
           RepID=C2HC06_ENTFC
          Length = 172

 Score =  166 bits (421), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 50/162 (30%), Positives = 90/162 (55%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKN 59
           M   + A   + +IG    +PW LP D+ +F+ +T+++ ++MGR T+E +G   LP R  
Sbjct: 1   MFISMWAQDRNGLIGKNGLLPWRLPNDMRFFREHTMDRILVMGRKTYEGMGDLSLPYRHI 60

Query: 60  IILSSQPG--TDDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+L++QP   T +    + S+DE +A       +I V GG R++++ LP   +++ T ID
Sbjct: 61  IVLTTQPNFRTKENAEVMHSIDELLAYSQTISEDIYVSGGSRIFQELLPYTGRIWRTLID 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +  EGDT+  D +  D+  +       D +N +++ F+  ER
Sbjct: 121 STFEGDTYIGDIDFSDFALIEEYEGITDQENLYAHRFQKWER 162


>UniRef50_C4Z3U6 Dihydrofolate reductase n=8 Tax=Firmicutes RepID=C4Z3U6_EUBE2
          Length = 157

 Score =  166 bits (421), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 52/161 (32%), Positives = 87/161 (54%), Gaps = 7/161 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI LI A + + VIG    +PW +  +  +FK  T+   V+MGR ++E IG PLP R+NI
Sbjct: 1   MIGLIVARSKNNVIGRNGEIPWKIKGEQKFFKELTIGNIVVMGRKSYEEIGHPLPNRQNI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I+S     + + +  V S+ EA+A   D   I + GG  VY++ +P    +Y+T +D  +
Sbjct: 61  IVSKTMKYEGENLITVSSLAEALA-LSDNSNIYIAGGYGVYKEAIPFVDVMYITEVDMNI 119

Query: 120 E-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E GD  FP+++ +D++ +  E    + +    Y      R+
Sbjct: 120 EDGDVFFPEFDVNDFDLIIGETFGENTK----YTRTTYIRK 156


>UniRef50_Q6A328 Dihydrofolate reductase n=1 Tax=Pasteurella multocida
           RepID=Q6A328_PASMU
          Length = 169

 Score =  165 bits (419), Expect = 4e-40,   Method: Composition-based stats.
 Identities = 49/164 (29%), Positives = 77/164 (46%), Gaps = 8/164 (4%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRKN 59
           SLI A+   R +G +N + W+LP D+ +FK  T    V+MGR +WESI    RPLP R N
Sbjct: 6   SLIVAIGKHREMGADNDLLWHLPRDMQFFKETTTGHAVVMGRKSWESIPQKYRPLPNRLN 65

Query: 60  IILSSQPGT-DDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLP--KAQKLYLTHI 115
            +L+       +  T +  + E             +IGG ++Y+  L      ++Y+T +
Sbjct: 66  FVLTRDKNYSAEGATVIYDLKEVAQHLEGKNLTCFIIGGAQIYQLALETGLLNEMYVTQV 125

Query: 116 DAEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
                E DT FP     +WE       D D ++ +S+  +   R
Sbjct: 126 HNTFEEADTFFPFVNWGEWEEEDILEQDKDEKHLYSFNIKKFTR 169


>UniRef50_Q8D3H9 FolA protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of
           Glossina brevipalpis RepID=Q8D3H9_WIGBR
          Length = 162

 Score =  165 bits (419), Expect = 4e-40,   Method: Composition-based stats.
 Identities = 70/159 (44%), Positives = 103/159 (64%), Gaps = 2/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI A + ++VIG +  +PWNLP D++WFK+NT+NKPVIMGR T+ESI +PL  R NI+
Sbjct: 3   ISLIWAQSKNKVIGHDQYIPWNLPEDISWFKKNTINKPVIMGRKTFESIKKPLENRINIV 62

Query: 62  LSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           LS     +    +   K+  +A+    +  E+M+IGG ++Y+ FLPKA KLYLT I+AE+
Sbjct: 63  LSKNLYRNVMSNLKIAKNPKQALFFAKNYNEVMIIGGKQIYKIFLPKATKLYLTVINAEI 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            G+  FP Y    W   F ++ ++D +N +S  F I  +
Sbjct: 123 NGNIFFPRYNRKKWILSFEKYFNSDTKNKYSMYFRIFNK 161


>UniRef50_B2GC42 Dihydrofolate reductase n=4 Tax=Lactobacillus RepID=B2GC42_LACF3
          Length = 167

 Score =  165 bits (419), Expect = 4e-40,   Method: Composition-based stats.
 Identities = 53/158 (33%), Positives = 81/158 (51%), Gaps = 4/158 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+ I A      IG +N MPW+L ADL  FK  T   PVIMG++T+ S+GRPLP R NI+
Sbjct: 4   IAFIWAEDEAGWIGKDNDMPWHLSADLKHFKHLTSGHPVIMGKNTYLSLGRPLPKRTNIV 63

Query: 62  LSSQPGTDDRVTWVKS---VDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++ Q    + VT V     + + +A  G+  E+ +IGG  ++   +  A  LY T ++ +
Sbjct: 64  VTRQTTPIEGVTLVNGVNALTDLLANYGEDEEVFIIGGAHLFASTMSLATVLYRTVVEGD 123

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
             GD      +   W+ V  E H    ++  +  FE  
Sbjct: 124 HHGDVKMAPIDYRTWQKVA-ERHLQATESDPACTFEKW 160


>UniRef50_UPI0001C35E5E dihydrofolate reductase region n=1 Tax=Clostridium hathewayi DSM
           13479 RepID=UPI0001C35E5E
          Length = 167

 Score =  164 bits (417), Expect = 6e-40,   Method: Composition-based stats.
 Identities = 48/164 (29%), Positives = 78/164 (47%), Gaps = 8/164 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59
           +  I A+     IG +  +  +LP D+ +F+  T  K V+MGR T +S    +PL  R N
Sbjct: 1   MKAIVAVDEAWGIGKDGKLLTHLPEDMKFFRTVTKGKVVVMGRKTLQSFPDAKPLKNRIN 60

Query: 60  IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+L+S    + + +   +SV +A+      D  ++ +IGG  VYEQFLP     Y+T + 
Sbjct: 61  IVLTSDAALNGEGLIVCRSVADALRQLKEYDSDDVYIIGGQSVYEQFLPYCDTAYVTRMK 120

Query: 117 AEVEGDTHFPDYEP-DDWESVFSEFHDADAQNSHSYCFEILERR 159
            +   DT F + +  + WE    E  D        + F   + R
Sbjct: 121 RDFGADTWFVNLDRQEGWEET--ETGDEKEYEGLHFTFCTYKNR 162


>UniRef50_C5NYS7 Dihydrofolate reductase n=1 Tax=Gemella haemolysans ATCC 10379
           RepID=C5NYS7_9BACL
          Length = 163

 Score =  164 bits (417), Expect = 6e-40,   Method: Composition-based stats.
 Identities = 51/160 (31%), Positives = 88/160 (55%), Gaps = 1/160 (0%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M+SLI A   ++ IG EN +PW L  D+   K  T N+ +IMGR T +SIGR LP R N 
Sbjct: 1   MLSLIVAYDKNKSIGQENTIPWRLKNDMLRVKELTTNQTIIMGRKTLDSIGRALPNRINR 60

Query: 61  ILSSQPGTDDRVTWVK-SVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +L+    +    + ++   D++I    +  +  + GGG +Y ++  K  ++++T ++  V
Sbjct: 61  VLTRDKDSLSHYSNIEVYTDDSILDNIETEKAYIFGGGMIYNKYFDKCDEMFITEVNTIV 120

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E DT FP+++ ++WE +  E    D  N   + F   +R+
Sbjct: 121 EADTKFPEFDENEWELISREEFFKDENNEFDFVFIHFKRK 160


>UniRef50_C3Z0P2 Putative uncharacterized protein n=2 Tax=Deuterostomia
           RepID=C3Z0P2_BRAFL
          Length = 185

 Score =  164 bits (417), Expect = 6e-40,   Method: Composition-based stats.
 Identities = 53/179 (29%), Positives = 86/179 (48%), Gaps = 23/179 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51
           +SL+ A   +  IG++  +PW L  D+ +F R T           V+MGR TW SI    
Sbjct: 6   LSLVVAACNNMGIGVDGKIPWTLRGDMKFFSRLTSGTEEAGKQNAVVMGRKTWFSIPDRF 65

Query: 52  RPLPGRKNIILSSQPGTDDRV--TWVKSVDEAIAA------CGDVPEIMVIGGGRVYEQF 103
           RPLP R N++LS    T          S++EA+           + ++ +IGG  VY+  
Sbjct: 66  RPLPKRLNVVLSRNLTTPPEGAHHLAGSLEEAVKMLTETTVADTIDKVFIIGGNSVYKDA 125

Query: 104 L--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVF--SEFHDADAQNSHSYCFEILER 158
           L  P   ++YLT +  +V  DT FP+ + D ++ V   +   +   +N   Y +E+ E+
Sbjct: 126 LSHPCCHRVYLTRVYKDVHCDTFFPNMD-DTFKLVSDPTIPSEMQEENGIEYKYEVYEK 183


>UniRef50_Q7UIC9 Dihydrofolate reductase n=1 Tax=Rhodopirellula baltica
           RepID=Q7UIC9_RHOBA
          Length = 195

 Score =  164 bits (416), Expect = 9e-40,   Method: Composition-based stats.
 Identities = 58/159 (36%), Positives = 85/159 (53%), Gaps = 3/159 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I+ + A   + VIG +  MPW L +DL  FK+ T+   +IMGR T+ESIGR LPGR+ I+
Sbjct: 31  ITAVVAATPNGVIGDDQDMPWRLSSDLKRFKKATMGGALIMGRKTFESIGRVLPGRQTIV 90

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+ Q               EAIA   D   I V+GGG++Y+Q+ P   +L+ T + A V 
Sbjct: 91  LTRQGHWQFPGTQTASGKSEAIALAAD-RRIFVVGGGQIYQQWFPLCTELWWTRVWANVS 149

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GDT   D   D++E V        A++ +   +  + RR
Sbjct: 150 GDTRV-DLPLDEFELVSQTSFPVTAKDDYPTDWLRMRRR 187


>UniRef50_B8DW85 Dihydrofolate reductase n=6 Tax=Bifidobacterium RepID=B8DW85_BIFA0
          Length = 227

 Score =  164 bits (415), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 64/181 (35%), Positives = 89/181 (49%), Gaps = 24/181 (13%)

Query: 2   ISLIAALAVD-----RVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RP 53
           ++LI A A D       IG E  MPW+LP DL  FK  T++ PVIMGR TWE++    RP
Sbjct: 37  VNLIWAQANDKEGRSGAIGYEGEMPWHLPEDLKRFKELTVSHPVIMGRKTWEALNEKFRP 96

Query: 54  LPGRKNIILSSQPGT-DDRVTWVKSVDEAIAACG---------DVPEIMVIGGGRVYEQF 103
           LP R NI+LS          T V +++EA+             D  EI VIGG +++ Q 
Sbjct: 97  LPNRDNIVLSRDRDFRAPGATVVDNLEEALDMARQEAIPDDGLDRSEIWVIGGSQLFNQM 156

Query: 104 LPKAQKLYLTHIDAEVEGDTHFPD----YEPDDWESVFSEFH--DADAQNSHSYCFEILE 157
           LP A K+Y+T +DA+V  D + PD         W+ + +         +    Y +   E
Sbjct: 157 LPMASKIYMTQVDAKVNADAYAPDLTEALNNGSWKLMENSGWLTPKKPEGIDRYRYLTFE 216

Query: 158 R 158
           R
Sbjct: 217 R 217


>UniRef50_UPI00016BFCBD Dihydrofolate reductase n=1 Tax=Epulopiscium sp. 'N.t. morphotype
           B' RepID=UPI00016BFCBD
          Length = 161

 Score =  164 bits (415), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 56/154 (36%), Positives = 94/154 (61%), Gaps = 4/154 (2%)

Query: 4   LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +I A++ +  IG+ N +PWN+  D+ +F++ T  K VIMGR T+ SIGRPLP R+NI+L+
Sbjct: 1   MIVAVSKNGQIGIANELPWNIKEDMNYFRKMTTAKTVIMGRKTFNSIGRPLPNRRNIVLT 60

Query: 64  SQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122
           +        V  V +  EA+    +  +  VIGGG++YE F+P A++LY+T +D +++GD
Sbjct: 61  TNTDLKIAGVEVVTNFAEALIIARE-EDAFVIGGGQIYELFMPYAEELYITEVDIDIDGD 119

Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
             FP+Y  + +  V +    A+  + ++Y F   
Sbjct: 120 AAFPEY-RNKFVCVETIEKSAN-DSKYNYRFTKW 151


>UniRef50_D1BYH5 Dihydrofolate reductase n=1 Tax=Xylanimonas cellulosilytica DSM
           15894 RepID=D1BYH5_XYLCX
          Length = 185

 Score =  164 bits (415), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 59/185 (31%), Positives = 81/185 (43%), Gaps = 26/185 (14%)

Query: 1   MISLIAALAVDR----VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLP 55
           MI+LI A A D     VIG    +PW +  D   F+  T   PV+MGR TW+S+  RPLP
Sbjct: 1   MIALIWAQARDTAGRPVIGAGGDIPWRVAEDFTRFRTLTTGHPVVMGRRTWDSLPRRPLP 60

Query: 56  GRKNIILSSQPGTDDR---------------VTWVKSVDEAIA---ACGDVPEIMVIGGG 97
           GR N++++ QP                    V    ++DEA+           + +IGG 
Sbjct: 61  GRTNVVVTRQPDWRPDDDGAVVTAGAPEATAVVVATTLDEALDGATQAPGGDLVWIIGGA 120

Query: 98  RVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADA---QNSHSYCFE 154
            +Y Q L  A +L +T ID  V+GD   P  +P  W        D  +     S  Y F 
Sbjct: 121 EIYGQALAVADRLEVTEIDLVVDGDAFAPAIDPVHWHEGQHGHGDWVSPARPESPRYRFR 180

Query: 155 ILERR 159
              RR
Sbjct: 181 TYVRR 185


>UniRef50_A3K5B9 Dihydrofolate reductase n=1 Tax=Sagittula stellata E-37
           RepID=A3K5B9_9RHOB
          Length = 153

 Score =  163 bits (414), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 60/142 (42%), Positives = 81/142 (57%), Gaps = 7/142 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MI+LIAA   +R IG +  +PW++P DLA FKR TL   ++MGR TWES+  +PL  R N
Sbjct: 1   MITLIAAHDRNRAIGKDGDIPWHIPEDLAMFKRETLGGAIVMGRKTWESLPFKPLKDRLN 60

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           I++S      +    V SV++AIA         I  IGG R+YE  LP A +L +T +D 
Sbjct: 61  IVVSRDTSLHE--HVVGSVEDAIALAQSQGYFRIYGIGGQRIYEAMLPLAHRLLITEVDT 118

Query: 118 EV-EGDTHFPDYEPDDWESVFS 138
            V E D  FPD   + W  V +
Sbjct: 119 VVEEADAFFPDVG-EGWREVST 139


>UniRef50_Q89AV2 Dihydrofolate reductase n=5 Tax=Buchnera aphidicola RepID=DYR_BUCBP
          Length = 164

 Score =  163 bits (414), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 71/160 (44%), Positives = 106/160 (66%), Gaps = 3/160 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS+I A++ + VIG +N++PWN+P DL+WFK++T+ K +IMGR TWESIGR LP R+NI+
Sbjct: 3   ISIIVAMSQNLVIGQKNSIPWNIPKDLSWFKKHTIKKSIIMGRKTWESIGRVLPMRQNIV 62

Query: 62  LSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           L+ Q    +  V +V S+ +AI +     EIM+IGG  +Y Q L  A KLY+THI+  + 
Sbjct: 63  LTRQKNIKNTNVLFVNSISKAIQSALYKNEIMIIGGSNLYNQMLTSANKLYITHIEKYIL 122

Query: 121 GDTHFPDYEPDDWESVFSEFHDADA--QNSHSYCFEILER 158
           GDT+FP Y+   W+ +F +        +NS    F+IL++
Sbjct: 123 GDTYFPTYDHLPWKIIFKKKIIEHEKTKNSFYVTFKILKK 162


>UniRef50_Q3A0W8 Dihydrofolate reductase n=1 Tax=Pelobacter carbinolicus DSM 2380
           RepID=Q3A0W8_PELCD
          Length = 167

 Score =  163 bits (413), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 54/159 (33%), Positives = 82/159 (51%), Gaps = 8/159 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++++ A+  +R+IG    +PW++P DLA F+R T    ++MGR T+ESIGRPLPGR NI+
Sbjct: 16  MTIVVAMTAERIIGRRGQLPWSIPEDLALFRRLTYGHTLVMGRRTFESIGRPLPGRFNIV 75

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120
           +S      + +   +   EA+        +I  IGG  +Y Q L  A KL ++ I     
Sbjct: 76  VSRSMPPVEGLRVCRHFAEALQVADQGNGDIFFIGGCEIYRQALIVAGKLSVSWIRKNYP 135

Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           GD  FP+Y  DDW     + +         +   I  RR
Sbjct: 136 GDCRFPEYRSDDWLIEQEQDYSE-------FRHIIYRRR 167


>UniRef50_B0MRL8 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM
           15702 RepID=B0MRL8_9FIRM
          Length = 161

 Score =  163 bits (413), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 49/161 (30%), Positives = 78/161 (48%), Gaps = 5/161 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           + +I A+  +  IG +  +  +L  DL   K  T+   ++MG  T+ S   RPLP R+N+
Sbjct: 1   MEIIVAVDENYGIGKDGDLLAHLSPDLKRLKAMTVGNIIVMGSKTYMSFPKRPLPDRENL 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           I++  P     +     VDE +       + I V+GGG VYEQ LP  +K ++T I    
Sbjct: 61  IITHHPENYPGIKCFTGVDEFLEYSKTADKPIFVLGGGSVYEQLLPYCEKAHITKILHSF 120

Query: 120 EGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCFEILERR 159
           E DT FP+ + + DWE    E      +  + + +    RR
Sbjct: 121 EADTFFPNLDNNPDWEKENEEDIVTGEK--YPFRYVTYVRR 159


>UniRef50_C5CC92 Dihydrofolate reductase n=3 Tax=Actinobacteria (class)
           RepID=C5CC92_MICLC
          Length = 186

 Score =  163 bits (413), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 62/176 (35%), Positives = 85/176 (48%), Gaps = 19/176 (10%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           +I++I A    RVIG +  MPW++P DLA F+ +T   PVIMGR TWES     RPLPGR
Sbjct: 11  VIAMIWAQTPGRVIGRDGTMPWHVPEDLAHFRAHTHGHPVIMGRRTWESFPARFRPLPGR 70

Query: 58  KNIILSSQPGTDD---------RVTWVKSV---DEAIAACGDVPEIMVIGGGRVYEQFLP 105
            NI++S      +             V        A A       + VIGG  +Y+Q L 
Sbjct: 71  TNIVVSRTLTATEQAGAQLRAAGAVVVPDFGAALAAAAEADGCDTVWVIGGATLYDQALD 130

Query: 106 KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHD---ADAQNSHSYCFEILER 158
            A +  +T IDA+V+GDTH P  +   W     +       D+ +   + FE  ER
Sbjct: 131 VASRAEVTVIDADVDGDTHAPPLDA-RWRRTAVDPAPDAWLDSASGPRHRFERWER 185


>UniRef50_B2UP70 Dihydrofolate reductase n=1 Tax=Akkermansia muciniphila ATCC
           BAA-835 RepID=B2UP70_AKKM8
          Length = 159

 Score =  162 bits (411), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 59/154 (38%), Positives = 83/154 (53%), Gaps = 8/154 (5%)

Query: 5   IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64
           + A+A DR IG   A+PW+LP DL  FKR T   PV+MGR T+ESIGRPLPGR+NI+L+ 
Sbjct: 10  VVAMAPDRGIGYRGALPWHLPDDLKTFKRITTGHPVLMGRKTYESIGRPLPGRQNIVLTR 69

Query: 65  QP-GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDT 123
            P  T + V  V S  E        PEIMVIGG  ++   +P   +++++ +  E   DT
Sbjct: 70  DPAWTAEGVQVVHSAGELECLELMDPEIMVIGGAEIFSLMMPAMSRMWVSKVKGEYPADT 129

Query: 124 HFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
             P +E     +V  E  +        +   + E
Sbjct: 130 FLPPFENRLERAVLKEHFE-------DFDLYLYE 156


>UniRef50_C7R3F1 Dihydrofolate reductase n=1 Tax=Jonesia denitrificans DSM 20603
           RepID=C7R3F1_JONDD
          Length = 191

 Score =  162 bits (411), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 56/164 (34%), Positives = 79/164 (48%), Gaps = 10/164 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           +SLI A +++ VIG    +PW+ P DLA F++ T    VIMGRHTWES+   PLP R NI
Sbjct: 11  LSLIWAQSLNGVIGRSGTIPWHEPTDLAHFQKTTRGGVVIMGRHTWESLPVTPLPQRVNI 70

Query: 61  ILSSQPGT-DDRVTWVKSVDEAIAACG-----DVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           +L+S           V +  +A+             I VIGG +VY+ F+  A +L +T 
Sbjct: 71  VLTSDRDYRAPGARVVTTPQQALDLAHWYTQVGHQAIWVIGGRQVYDTFMDYATQLIVTT 130

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +   +EGDT  P   P     V  E H     + +        R
Sbjct: 131 VGTVIEGDTEAPRIPP---HFVPQEPHQLATHSDYEVTVTTWLR 171


>UniRef50_Q3F0Y0 Dihydrofolate reductase n=2 Tax=Bacillus thuringiensis
           RepID=Q3F0Y0_BACTI
          Length = 172

 Score =  162 bits (411), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 57/171 (33%), Positives = 82/171 (47%), Gaps = 12/171 (7%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           MISLI A   +  IG EN +   L  D+  F + T  KP+IMG  T+ S+G +PL  R N
Sbjct: 1   MISLIVAADENNAIGFENKLLCRLKDDMKHFIKKTKGKPIIMGYKTFASLGHKPLKDRFN 60

Query: 60  IILSSQP--------GTDDRVTWVKSVD--EAIAACGDVPEIMVIGGGRVYEQFLPKAQK 109
           I+L+  P                 +S++  + +       EI+VIGG + YE FLP A +
Sbjct: 61  IVLTRSPMALTLDHLHLVGENLVFESLEYIQFMIEQSKDKEIVVIGGQQTYELFLPMASR 120

Query: 110 LYLTHIDAEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +YLT I     E D++FP  +  +W S     H     N H +     ER+
Sbjct: 121 VYLTRIHHSFPEADSYFPMLDSSEWSSKLDAKHAESEDNDHPFSIYTFERK 171


>UniRef50_C4Z7Z2 Dihydrofolate reductase n=34 Tax=Bacteria RepID=C4Z7Z2_EUBR3
          Length = 163

 Score =  162 bits (410), Expect = 4e-39,   Method: Composition-based stats.
 Identities = 47/163 (28%), Positives = 80/163 (49%), Gaps = 8/163 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59
           ++LIAA+  +  IG  N +   +P D  +F+  T  K V+MGR T ES    RPL  R N
Sbjct: 1   MNLIAAVDNNWAIGKNNQLLVRIPMDQKFFREMTTGKVVVMGRKTLESFPNSRPLKNRTN 60

Query: 60  IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           I+L+  P  + +    V S+DE        +  +I +IGG ++YEQ + +    ++T +D
Sbjct: 61  IVLTHNPSYEVEGAVVVHSLDELHKELEKYNSEDIYIIGGQKIYEQLVDECDVAHITKVD 120

Query: 117 AEVEGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCFEILER 158
            E + D +FP+ +   +W+       +        + F   E+
Sbjct: 121 FEYDADAYFPNLDEKPEWQIT--GDSEEQTYFDLEFYFLRYEK 161


>UniRef50_A5WHY1 Dihydrofolate reductase n=4 Tax=Moraxellaceae RepID=A5WHY1_PSYWF
          Length = 193

 Score =  162 bits (410), Expect = 4e-39,   Method: Composition-based stats.
 Identities = 56/179 (31%), Positives = 88/179 (49%), Gaps = 28/179 (15%)

Query: 5   IAALAVDRVIGMENAMPWNLPADLAWFKRNTL-----------NKPVIMGRHTWESIG-R 52
           I A++ +R IG  N +PW++P DL  FK  T               VIMGR T+ES+G +
Sbjct: 11  IVAISRNRCIGKGNDLPWHIPNDLKHFKAMTTAETDAYVDTGLKGIVIMGRKTFESMGSK 70

Query: 53  PLPGRKNIILSSQPGTD--------DRVTWVKSVDEAIAACGDV------PEIMVIGGGR 98
           PLP R N I+++Q              V  V ++D+A+    +V        I VIGG R
Sbjct: 71  PLPKRVNFIVTTQMDYAQQKGLEGLKDVHVVHNLDDALTHAANVAHGLKFETIWVIGGER 130

Query: 99  VYEQFLPKAQKLYLTHIDAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
           V+++ +    ++ LT +D ++E GD  +P+  P+D+E         D ++  SY F   
Sbjct: 131 VFKRAMMFTDRIELTVVDTDIEDGDAFYPEI-PEDFELTQESESFTDEKSGLSYKFMTY 188


>UniRef50_Q494F1 Dihydrofolate reductase type I n=1 Tax=Candidatus Blochmannia
           pennsylvanicus str. BPEN RepID=Q494F1_BLOPB
          Length = 164

 Score =  161 bits (408), Expect = 6e-39,   Method: Composition-based stats.
 Identities = 76/162 (46%), Positives = 106/162 (65%), Gaps = 4/162 (2%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           +ISLIAAL  + +IG +N +PW LP D+ WFK +TL KP+IMGR T+ESIG +PL  R N
Sbjct: 2   IISLIAALTTNHIIGKKNVIPWYLPIDIKWFKYHTLYKPIIMGRKTFESIGKKPLLNRLN 61

Query: 60  IILSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA- 117
           I+LS       + V   +++DEA++   D  E+MVIGG  +Y  FLP+AQ+LYLT+I   
Sbjct: 62  IVLSRNLLNNYNGVFIAENIDEALSLIQDAYEVMVIGGSEIYNVFLPRAQRLYLTYIHNM 121

Query: 118 -EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            E++GD  FPDY+  +W+S+F+ F+           F ILER
Sbjct: 122 VEIDGDILFPDYDIREWKSIFNSFYKVREDCFCYLHFSILER 163


>UniRef50_C4WVU0 ACYPI002804 protein n=1 Tax=Acyrthosiphon pisum RepID=C4WVU0_ACYPI
          Length = 184

 Score =  161 bits (408), Expect = 7e-39,   Method: Composition-based stats.
 Identities = 51/177 (28%), Positives = 87/177 (49%), Gaps = 19/177 (10%)

Query: 1   MI-SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL-------NKPVIMGRHTWESIG- 51
           M+ S+IAA++ +  IG +  +PW +  ++ +F   T           VIMGR TW+SI  
Sbjct: 7   MVYSVIAAVSKNGGIGYKGNLPWKIKKEMEYFNLMTTRVNLKGVQNAVIMGRCTWQSIPD 66

Query: 52  --RPLPGRKNIILSSQPGT-DDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLP 105
             RPL GR N+++S    +  + V     ++EA+ +      +  + VIGG  +Y++ + 
Sbjct: 67  KYRPLKGRINVVISKTLNSVPEGVLLYPKLEEALKSLYLNDRIENLWVIGGSGLYKEAVN 126

Query: 106 --KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDA--DAQNSHSYCFEILER 158
               +KL++T ID E   DT FPD++   +E              N   Y F++ +R
Sbjct: 127 DKNCKKLFITKIDQEYLCDTFFPDFDTKKFEETSEANVPKGIQEDNGIKYEFKVFKR 183


>UniRef50_UPI000006EBF1 PREDICTED: hypothetical protein XP_002346735 n=1 Tax=Homo sapiens
           RepID=UPI000006EBF1
          Length = 262

 Score =  161 bits (407), Expect = 9e-39,   Method: Composition-based stats.
 Identities = 48/181 (26%), Positives = 84/181 (46%), Gaps = 24/181 (13%)

Query: 2   ISLIAALAVDRVIGMENAMPWN-LPADLAWFKRNTL-------NKPVIMGRHTWESIG-- 51
           ++ I A++ +  IG    +PW  L  +  +F+R T           VIMG+ TW SI   
Sbjct: 80  LNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEK 139

Query: 52  -RPLPGRKNIILSSQPGTDDRVTWV--KSVDEAI------AACGDVPEIMVIGGGRVYEQ 102
            RPL GR N++LS +     +      +S+D+A+           V  + ++GG  VY++
Sbjct: 140 NRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKE 199

Query: 103 FLPKAQ--KLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFH---DADAQNSHSYCFEILE 157
            +      KL++T I  + E DT FP+ + + ++ +        D   +    Y FE+ E
Sbjct: 200 AMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYE 259

Query: 158 R 158
           +
Sbjct: 260 K 260


>UniRef50_Q9CBW1 Dihydrofolate reductase n=25 Tax=Actinomycetales RepID=DYR_MYCLE
          Length = 165

 Score =  161 bits (407), Expect = 9e-39,   Method: Composition-based stats.
 Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 10/165 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           ++ LI A +   VIG +  MPW +P DL  FK+ T+  PV+MGR TW+S+    RPLPGR
Sbjct: 3   VVGLIWAQSTTGVIGRDGGMPWRVPEDLTRFKQLTMGHPVVMGRRTWDSLPVGVRPLPGR 62

Query: 58  KNIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +NI+LS Q     +      S++E I+     PE+ VIGG ++Y   LP A +  +T +D
Sbjct: 63  RNIVLSRQIDFMAEGAEVFGSLEETISNLETEPEMWVIGGEQIYRLALPLATRCGVTEVD 122

Query: 117 AEV---EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             +   + D   P  + D W  V  E+  + +     Y      R
Sbjct: 123 TYLLHEDDDVLAPVLD-DTWVGVTGEWLVSCS--GLRYRLHSYHR 164


>UniRef50_Q2S5H3 Dihydrofolate reductase n=3 Tax=cellular organisms
           RepID=Q2S5H3_SALRD
          Length = 186

 Score =  160 bits (406), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 66/168 (39%), Positives = 94/168 (55%), Gaps = 17/168 (10%)

Query: 2   ISLIAALAV-DRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPG 56
           + +IAA+A  +RVIG +  +PW++P DL  FK+ T   P++MGR T+ESI    G PLP 
Sbjct: 21  LVIIAAVAEDNRVIGQDKDLPWHIPEDLKRFKQLTTGHPLLMGRRTFESIVHQFGGPLPD 80

Query: 57  RKNIILSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           RK ++L++Q   +    V    SVD A+AA  D   + + GG  VYEQFLP A +L LT 
Sbjct: 81  RKMVVLTTQDDYEAYPEVDTYASVDAALAALPDDATVFIGGGESVYEQFLPHADRLELTL 140

Query: 115 IDAEVEGDTHFPDYEP---DDWESVFSEFHDADAQNSHSYCFEILERR 159
           ++   EGDT FP +E    D +E    +  D        + F   ER+
Sbjct: 141 VEGAYEGDTFFPPFEHLIGDVFEETAVDARDG-------FRFVTYERK 181


>UniRef50_Q93341 Putative dihydrofolate reductase n=2 Tax=Caenorhabditis
           RepID=DYR_CAEEL
          Length = 189

 Score =  159 bits (404), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 51/181 (28%), Positives = 76/181 (41%), Gaps = 25/181 (13%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51
           ++LI A+  +  IG    +PW +  D+ +F   T N         V+MGR  WESI    
Sbjct: 4   MNLIVAMDAEGGIGKNGVLPWRIKKDMQYFASVTKNVSDQSKRNAVLMGRKCWESIPVTR 63

Query: 52  RPLPGRKNIILSSQP--GTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQF 103
           RPL GR NI+LS Q      D    V S++ A+    +      +  I  IGG  +Y+  
Sbjct: 64  RPLAGRLNIVLSRQLPAQKSDDYIVVNSLEAAMKLLSEPPFVDSIETIWNIGGAEIYDLA 123

Query: 104 L--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWE-----SVFSEFHDADAQNSHSYCFEIL 156
           L      +++LT I    E D H    +    E      V SE  +   +N   + F   
Sbjct: 124 LRENLVDEIHLTRIFKNFEADVHLKSLDFSKMEKVQNAEVSSENSEIFEENGLKFEFCKW 183

Query: 157 E 157
           +
Sbjct: 184 K 184


>UniRef50_B0VHY5 Dihydrofolate reductase n=1 Tax=Candidatus Cloacamonas
           acidaminovorans RepID=B0VHY5_9BACT
          Length = 141

 Score =  159 bits (404), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 56/141 (39%), Positives = 80/141 (56%), Gaps = 4/141 (2%)

Query: 20  MPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD-RVTWVKSV 78
           MPW +  DL  FK  T+  PVIMG++TW SIG+PLPGR+NI+LS              S+
Sbjct: 1   MPWKITEDLKRFKAITMGHPVIMGKNTWNSIGKPLPGRQNIVLSKDRNFQPQGAIVAHSL 60

Query: 79  DEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFS 138
           +EA+       E  +IGG  V++QFLP A K+ +T I +E EGDT+FP +  +DW     
Sbjct: 61  EEALKMVEG-QEAYIIGGASVFKQFLPLADKMLITLIHSEFEGDTYFPYFSEEDWIL--Q 117

Query: 139 EFHDADAQNSHSYCFEILERR 159
           E     + + +  C +I  R+
Sbjct: 118 ESSSLLSSSGYELCLQIYIRK 138


>UniRef50_D2Q8R3 DfrA Dihydrofolate reductase n=12 Tax=Bifidobacterium
           RepID=D2Q8R3_9BIFI
          Length = 224

 Score =  159 bits (403), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 62/182 (34%), Positives = 84/182 (46%), Gaps = 25/182 (13%)

Query: 2   ISLIAALAVD-----RVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI---GRP 53
           ++LI A A D       IG E  MPW LP D+  F   T++ PVIMGR TWE++    RP
Sbjct: 39  VNLIWAQARDKEGRDGAIGFEGGMPWRLPEDMKHFTELTVSHPVIMGRRTWEALSPKFRP 98

Query: 54  LPGRKNIILSSQPGT-DDRVTWVKSVDEAIAACG---------DVPEIMVIGGGRVYEQF 103
           LP R NI++S  P       T V ++D+A+             D  EI +IGG +V+   
Sbjct: 99  LPNRDNIVISHDPAYSAPGATVVDTLDDALDLARQEAIPDDGLDRSEIWIIGGAQVFRDA 158

Query: 104 LPKAQKLYLTHIDAEVEGDTHFPDY----EPDDWESVFSEFHDADAQNSHS---YCFEIL 156
           LP A K Y+T I   V+ DT+ PD     E   W            + S     + F   
Sbjct: 159 LPFADKAYVTQISMHVDADTYAPDIASLAESGAWRMAEEGVWQGTQKGSDDIAGFRFVTY 218

Query: 157 ER 158
           E+
Sbjct: 219 EK 220


>UniRef50_C1C2C0 Dihydrofolate reductase n=1 Tax=Caligus clemensi RepID=C1C2C0_9MAXI
          Length = 178

 Score =  159 bits (403), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 52/168 (30%), Positives = 86/168 (51%), Gaps = 14/168 (8%)

Query: 2   ISLIAALAVD-RVIGMENAMPWNLPADLAWFKRNTLNKP-----VIMGRHTWESIG---R 52
           I++IAA     R IG +N +PW LP D+ +F+  T +       VIMGR TWES+    R
Sbjct: 9   INVIAAACKSSRGIGKDNDLPWKLPTDMKYFREKTASTTEIRVGVIMGRRTWESVPPKFR 68

Query: 53  PLPGRKNIILSSQPGTD-DRVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLP-KAQK 109
           P   R N++L+S+   +       +++++A+  C  +V  I VIGG  VY + L     +
Sbjct: 69  PFKNRFNVVLTSREDFEAKGAVIARTLEDAVKKCSNNVDSIWVIGGSGVYAEALNKYPCR 128

Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
           +YLT ID E + D  FP  +   ++           +N  ++ F++ +
Sbjct: 129 VYLTEIDKEFDCDAFFPPLDEKKYKLAS--VSPDHQENDITFRFKVYD 174


>UniRef50_C9KQJ5 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
           n=2 Tax=Veillonellaceae RepID=C9KQJ5_9FIRM
          Length = 342

 Score =  159 bits (403), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 48/164 (29%), Positives = 72/164 (43%), Gaps = 17/164 (10%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59
           +S+IA +   R IG    +  +LP D+  F+  T    VIMGR T ES+   RPL  R+N
Sbjct: 168 LSMIACIDEGRGIGYRGELLVHLPEDMKHFRALTEGHVVIMGRRTMESLPGKRPLVNRQN 227

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLT 113
           I+LS Q    +      S+ +   A           ++  IGG  +Y   LP A ++ LT
Sbjct: 228 IVLSRQLEGAEGFLICHSLPDLWRALGRLRAEKPQRKLWCIGGEELYRALLPYAHEVCLT 287

Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
            + A    D  FP  +  D+  V ++  +          FE  E
Sbjct: 288 RLKAVYPADCFFPPLD--DFSLVDTDDREG-------LVFERYE 322


>UniRef50_Q59487 Dihydrofolate reductase n=17 Tax=Streptococcaceae RepID=DYR_LACLA
          Length = 168

 Score =  159 bits (403), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 51/164 (31%), Positives = 89/164 (54%), Gaps = 6/164 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59
           MI  I A     +IG  + MPW+LPA+   FK  T+N+ ++MGR T+E +  R LPGR +
Sbjct: 1   MIIGIWAEDEAGLIGEADKMPWSLPAEQQHFKETTMNQVILMGRKTFEGMNKRVLPGRIS 60

Query: 60  IILSSQPGT---DDRVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           IIL+        +++V  + S  E +        ++ + GG  +   F  + + LY T +
Sbjct: 61  IILTRDETYQSDNEKVLIMHSPKEVLDWYHKQNKDLFITGGAEILALFESELELLYRTVV 120

Query: 116 DAEVEGDTHFPD-YEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             + +GDT+FP  ++   ++ V  +FHD D +NS+++  +  E+
Sbjct: 121 HEKFKGDTYFPSTFDFGRFKLVSEKFHDKDERNSYTFTIKKYEK 164


>UniRef50_Q13PE2 Dihydrofolate reductase n=1 Tax=Burkholderia xenovorans LB400
           RepID=Q13PE2_BURXL
          Length = 171

 Score =  159 bits (402), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 61/157 (38%), Positives = 84/157 (53%), Gaps = 7/157 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + L+AA+A +RVIG+ N +PW +P +   F+  T+N+ V+MGR T+ESIG+PLPGR  ++
Sbjct: 7   VVLVAAMAANRVIGLGNDIPWRIPGEQKRFRELTMNQLVVMGRRTFESIGKPLPGRDLLV 66

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           LSS       V  VKS  E  AA  + P   I V GG +VY   +P A  +YLT ID   
Sbjct: 67  LSSGTSRLGTVRTVKSFAEVTAAVNNDPREAIFVGGGQQVYAMLMPYADVVYLTEIDLRP 126

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
            GD  FP+  P+ +    S            Y F   
Sbjct: 127 PGDAFFPEI-PERFSLPDSVDFP----GEIRYTFNTY 158


>UniRef50_B7C7C2 Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM
           3989 RepID=B7C7C2_9FIRM
          Length = 159

 Score =  158 bits (401), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 48/158 (30%), Positives = 83/158 (52%), Gaps = 5/158 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ++LIAA+  +R +G  N M W+LP DL +F++ T    ++MGR T+ES+   LP R +++
Sbjct: 3   LTLIAAIGKNRELGKNNDMIWHLPQDLKFFRQETSGHTIVMGRKTFESLPGKLPKRHHVV 62

Query: 62  LSSQ-PGTDDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +S       + +   +SV+E +    D   EI  IGGG +Y + L  A +L LT IDA+ 
Sbjct: 63  ISRTCKDLGEDIEMCESVEEFMKRYKDVDEEIYCIGGGMIYSEMLKYASRLVLTQIDADA 122

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
           + + +FP+++   +     +      +N   Y      
Sbjct: 123 DAEVYFPEFDESLYN---KKILSNIEENGVFYQHVEYT 157


>UniRef50_D2RRK6 Dihydrofolate reductase n=1 Tax=Haloterrigena turkmenica DSM 5511
           RepID=D2RRK6_9EURY
          Length = 181

 Score =  157 bits (399), Expect = 7e-38,   Method: Composition-based stats.
 Identities = 58/168 (34%), Positives = 83/168 (49%), Gaps = 20/168 (11%)

Query: 5   IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNI 60
           I A+A + VIG +  MPW++PADL  FK  T++ P+IMGR T+E I    G PLPGR  +
Sbjct: 19  IVAVADNGVIGKDGDMPWHIPADLKHFKETTMDHPIIMGRVTYEGILEALGEPLPGRTTV 78

Query: 61  ILS-SQPGTDDRVTWVKS--------VDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLY 111
           +L+     T +     +S           A         I V GG  VYEQFL    +L 
Sbjct: 79  VLTSRDLETPENAVTARSLEEALEAAETAARERHDAADRIFVAGGATVYEQFLSALDRLI 138

Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +T +  E +GDT+FPD++   ++ V  +  D        + F    RR
Sbjct: 139 VTEVHEEPDGDTYFPDWDRASFDDVSRDDRDG-------FAFVEYVRR 179


>UniRef50_A1WYQ0 Dihydrofolate reductase n=1 Tax=Halorhodospira halophila SL1
           RepID=A1WYQ0_HALHL
          Length = 164

 Score =  157 bits (399), Expect = 9e-38,   Method: Composition-based stats.
 Identities = 60/161 (37%), Positives = 80/161 (49%), Gaps = 8/161 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           I L+A +  + VIG +   PW+   DL  FK  T   PVIMGR T  +IGRPLP R NI+
Sbjct: 4   IVLVAIVGRNGVIGADGDQPWHFRCDLQRFKALTRGHPVIMGRRTLAAIGRPLPQRTNIV 63

Query: 62  LSSQPGTD-DRVTWVKSVD---EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           L+  PG   D V      +      A       +M++GGG VY  FLP+A +L LT +D 
Sbjct: 64  LTRDPGFHADGVEVATDPEAALARAAESAGGERVMILGGGDVYRLFLPRAHRLALTEVDD 123

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
              GDT FP   P +W+    E      ++ +   F  L R
Sbjct: 124 APPGDTTFPAIGP-EWQETAREE---AEEDGYRLTFRTLLR 160


>UniRef50_C0QWN0 Dihydrofolate reductase n=2 Tax=Brachyspira RepID=C0QWN0_BRAHW
          Length = 166

 Score =  157 bits (398), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 56/167 (33%), Positives = 90/167 (53%), Gaps = 12/167 (7%)

Query: 1   MISLIAALAVDRVIGMENAMPW-NLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRK 58
           ++SLIAA+     IG+   MPW ++  D+ +F+  T    VIMGR T+ES+G +PLP RK
Sbjct: 2   IVSLIAAVDSKNGIGLNGVMPWGHIKEDMQFFRSTTTGYAVIMGRVTFESLGSKPLPNRK 61

Query: 59  NIILSSQPGTD-----DRVTWVKSVDEAIA--ACGDVPEIMVIGGGRVYEQFLPKAQKLY 111
           NI++SS   T+     D + + KS +++I+        +I +IGG  +Y++ L  A  +Y
Sbjct: 62  NIVISSNVNTELLNKYDNLFYEKSFEDSISKLLLEKNKQIFIIGGESIYKKALDYADMIY 121

Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           LTHID +   D  FP+ + + ++S   +       N  S       R
Sbjct: 122 LTHIDKDYHCDRFFPEIDTNLFQSDELKTFFY---NDISVNIIKYTR 165


>UniRef50_P17719 Dihydrofolate reductase n=21 Tax=Endopterygota RepID=DYR_DROME
          Length = 182

 Score =  157 bits (397), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 51/178 (28%), Positives = 85/178 (47%), Gaps = 22/178 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRN-------TLNKPVIMGRHTWESIG--- 51
            +LI A+  +  IG+   +PW + ++L +F R        T    V+MGR T+  +    
Sbjct: 4   FNLIVAVCENFGIGIRGDLPWRIKSELKYFSRTTKRTSDPTKQNAVVMGRKTYFGVPESK 63

Query: 52  RPLPGRKNIILSSQPGTDD---RVTWVKSVDEA---IAACGDVPEIMVIGGGRVYEQFL- 104
           RPLP R NI+LS+     D    V    +++ A   +    +V  I ++GG  VYE+ + 
Sbjct: 64  RPLPDRLNIVLSTTLQESDLPKGVLLCPNLETAMKILEEQNEVENIWIVGGSGVYEEAMA 123

Query: 105 -PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESV---FSEFHDADAQNSHSYCFEILER 158
            P+  +LY+T I  + + DT FP   PD +  V            +N   + ++ILE+
Sbjct: 124 SPRCHRLYITKIMQKFDCDTFFPAI-PDSFREVAPDSDMPLGVQEENGIKFEYKILEK 180


>UniRef50_C7N8V9 Dihydrofolate reductase region n=5 Tax=Fusobacteriaceae
           RepID=C7N8V9_LEPBD
          Length = 173

 Score =  157 bits (397), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 54/177 (30%), Positives = 93/177 (52%), Gaps = 26/177 (14%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M SLI A+  +  IG  N + W++P DL  FK+ T+ K VIMG++T++SIG+PLP RKNI
Sbjct: 1   MFSLIVAVGENNEIGKNNQLLWHIPEDLKNFKKITMGKTVIMGKNTYKSIGKPLPNRKNI 60

Query: 61  ILSSQPGTDDR---------------VTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQF- 103
           +LS  P   +                +    ++ + I    +   EI +IGGG +Y++  
Sbjct: 61  VLSRNPLEIEEKIKEDRKKYENENTKLELCDNLQKIIDKYKNSEEEIFIIGGGEIYKKAF 120

Query: 104 -LPKAQKLYLTHID-AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            +   +++Y++H++ ++   DT+FP  +   W  +  E +D        + F I E+
Sbjct: 121 EMKIVKRIYMSHVNFSDKNADTYFPKIDLKKWVVITKENYDG-------WRFCIYEK 170


>UniRef50_B3RI81 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3RI81_TRIAD
          Length = 174

 Score =  157 bits (397), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 55/174 (31%), Positives = 84/174 (48%), Gaps = 24/174 (13%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG---RPLPGR 57
           +  DR IG +N +PW L  +  +F R T +         V+MGR+TW SI    RPL  R
Sbjct: 1   MTRDRGIGYKNDLPWKLRNEYKYFARLTTSTKDSAKKNAVLMGRNTWVSIPEKNRPLRNR 60

Query: 58  KNIILSSQ---PGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFL--PK 106
            NI++SSQ       + V  V S+ E I           V  + ++GG  VY+ F+  P+
Sbjct: 61  INIVISSQLRAEEVPEGVHVVASIPEVIELVQSPLLKDIVETVWIVGGAPVYKGFMSHPQ 120

Query: 107 AQKLYLTHIDAEVEGDTHFPDYEPDDWESVF--SEFHDADAQNSHSYCFEILER 158
             ++YLT +DA  E D  FP+   DD++ +       +   +N   Y F + +R
Sbjct: 121 CDRIYLTKLDANYECDVFFPEM-SDDFKEISDPDVSQEVQEENGLKYTFHVYQR 173


>UniRef50_P00374 Dihydrofolate reductase n=50 Tax=root RepID=DYR_HUMAN
          Length = 187

 Score =  157 bits (397), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 48/181 (26%), Positives = 84/181 (46%), Gaps = 24/181 (13%)

Query: 2   ISLIAALAVDRVIGMENAMPWN-LPADLAWFKRNTL-------NKPVIMGRHTWESIG-- 51
           ++ I A++ +  IG    +PW  L  +  +F+R T           VIMG+ TW SI   
Sbjct: 5   LNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEK 64

Query: 52  -RPLPGRKNIILSSQPGTDDRVTWV--KSVDEAI------AACGDVPEIMVIGGGRVYEQ 102
            RPL GR N++LS +     +      +S+D+A+           V  + ++GG  VY++
Sbjct: 65  NRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKE 124

Query: 103 FLPKAQ--KLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFH---DADAQNSHSYCFEILE 157
            +      KL++T I  + E DT FP+ + + ++ +        D   +    Y FE+ E
Sbjct: 125 AMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYE 184

Query: 158 R 158
           +
Sbjct: 185 K 185


>UniRef50_UPI00015B4DEB PREDICTED: similar to conserved hypothetical protein n=1
           Tax=Nasonia vitripennis RepID=UPI00015B4DEB
          Length = 184

 Score =  156 bits (395), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 51/179 (28%), Positives = 84/179 (46%), Gaps = 22/179 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT-------LNKPVIMGRHTWESIG--- 51
           + LIAA   +  IG+   +PW L  ++ +F + T           V+MGR TWESI    
Sbjct: 5   LKLIAAACENMGIGVNGDLPWRLRKEMDFFTKMTSTTKDENKKNVVLMGRRTWESIPKKF 64

Query: 52  RPLPGRKNIILSSQP-GTDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFL 104
           +PL  R N++L+SQP    +     K++ EAI           V ++ VIGG  VY+  +
Sbjct: 65  KPLSNRINMVLTSQPLDLGEDAIVCKNLPEAIEKISQSPLKDKVEQVWVIGGSLVYKTSM 124

Query: 105 PKAQ--KLYLTHIDAEVEGDTHFPDYEPDDWESVF--SEFHDADAQNSHSYCFEILERR 159
                 +LYLT +  + + D  FP+  P+D+  V           +    + +E+ E++
Sbjct: 125 ESPNFYRLYLTRVKKDFKCDAFFPEI-PNDYILVKDPEVPEGIQEEKDIKFEYEVYEKK 182


>UniRef50_D1YEK5 Dihydrofolate reductase n=3 Tax=Propionibacterium acnes
           RepID=D1YEK5_PROAC
          Length = 156

 Score =  156 bits (394), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 49/161 (30%), Positives = 74/161 (45%), Gaps = 11/161 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +  IAA+A + VIG    M W++  D   FK  T+   +I GR T+E IG+ LPGR++II
Sbjct: 3   VVAIAAVADNGVIGSGQDMLWHISEDFRRFKTVTMGHTLIFGRRTFEQIGK-LPGRRHII 61

Query: 62  LSSQP-GTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
            +  P  + + V    S  +A+    +  E    V GGG++Y        +L +T +   
Sbjct: 62  CTRDPHWSHEGVDVATSPRQAVEMAREAGEEICFVAGGGQIYADTFELCDELDITEVHQN 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
             G   FP  +P+ W  V  E  D        + F    RR
Sbjct: 122 PNGAARFPAIDPEVWVEVRRESRDG-------FDFVGYRRR 155


>UniRef50_C3PEY4 Dihydrofolate reductase n=9 Tax=Corynebacterium RepID=C3PEY4_CORA7
          Length = 181

 Score =  156 bits (394), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 53/180 (29%), Positives = 79/180 (43%), Gaps = 23/180 (12%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI---GRPLPGR 57
           M+  I A ++D VIG    MPW++P DL  FK  T+  PVIMGR TWES+    RPLPGR
Sbjct: 1   MLGAIWAQSLDGVIGDGVVMPWHVPEDLKHFKEVTMGAPVIMGRKTWESLTPKFRPLPGR 60

Query: 58  KNIILSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT-- 113
            NI+LS +         T V ++D A+     + +  +IGGG++Y   L +   + LT  
Sbjct: 61  DNIVLSRREPGEWSAGATVVDNLDAAL--HATLDDAWIIGGGQLYSSALDRVDTIELTLM 118

Query: 114 --HIDAEVEGDTHFPDYEPDDWESVFSEFHDADA------------QNSHSYCFEILERR 159
              +      D       P+++                        +    Y F   +R+
Sbjct: 119 GVQVGDAYGADAVLAPSVPEEFSLSADSDWLTSESGHLTIPGQPPSELPMKYRFLTYDRK 178


>UniRef50_C7REN4 Dihydrofolate reductase region n=2 Tax=Anaerococcus
           RepID=C7REN4_ANAPD
          Length = 164

 Score =  155 bits (393), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 45/161 (27%), Positives = 76/161 (47%), Gaps = 5/161 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + +I A+  +  IG +  M +++  DL  FK  TL    IMGR T+ES+G  L  R+NI+
Sbjct: 1   MKIILAVDKNWGIGKDGQMLFHIRRDLKHFKSYTLGNICIMGRKTYESMGGALTHRENIV 60

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           LS                 + ++   +   E+ VIGG ++ E FL    +  +T I  + 
Sbjct: 61  LSRNKDYKAKDAKVFTDYRDVLSYVRERSEEVFVIGGEKIVEIFLEYCDEAIITKIYEKK 120

Query: 120 EGDTHFPDYE-PDDWESVFSEFHDADAQNSHSYCFEILERR 159
           + D+   +++  DDW    SE  D   +N  S+ +    R+
Sbjct: 121 DADSFLHNFDQDDDWSL--SEESDIMEENGVSFRYVRYRRK 159


>UniRef50_C7XU42 Dihydrofolate reductase n=1 Tax=Lactobacillus coleohominis
           101-4-CHN RepID=C7XU42_9LACO
          Length = 166

 Score =  155 bits (393), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 46/159 (28%), Positives = 72/159 (45%), Gaps = 4/159 (2%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS + A      IG    +PW+LP DL  FK  T + P++MG  T+ SIGRPLP R NI+
Sbjct: 3   ISFVWAEDEAGWIGKNGQLPWHLPVDLKHFKTVTDHHPIVMGARTFASIGRPLPNRPNIV 62

Query: 62  LSSQPGTDDRVTWVKSVDEAIAA----CGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +S  P   D+V  V ++++ +        D  E+ +IGG  ++ Q +     L+ T +  
Sbjct: 63  VSHHPVAVDQVITVTNIEDLMNLIFKRYADQEEVCIIGGAGLFAQMVAHVNCLHRTIVMG 122

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
              GD      +   W+             + +  FE  
Sbjct: 123 NHHGDVKMIPIDYHQWQLTKKTPVYNSKTGALNCYFEEW 161


>UniRef50_Q0G0R9 Dihydrofolate reductase n=2 Tax=Aurantimonadaceae
           RepID=Q0G0R9_9RHIZ
          Length = 178

 Score =  155 bits (393), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 54/165 (32%), Positives = 84/165 (50%), Gaps = 7/165 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
              + A A + VIG +  MPW++P+DL  ++  T+ KP+IMGR T E+IG+ L GR +I+
Sbjct: 8   FVAVVAAAKNGVIGADGGMPWSIPSDLKRYRSLTMGKPMIMGRKTLEAIGKALDGRDSIV 67

Query: 62  LSSQPGTD-DRVTWVKSVDEAIAA------CGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           L+ +     D         EAIA            EI V+GG  +Y        ++ LT 
Sbjct: 68  LTRENRLAVDGAMLASGPAEAIAKAIECASARRASEIAVVGGAEIYRLLWDHIDRIALTE 127

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           +DAE EGD  FP  +  ++E +  E      ++S +  F+  +RR
Sbjct: 128 VDAEPEGDAVFPAIDESEFELLSEEPWIRGERDSAATRFKSYQRR 172


>UniRef50_B9DU71 Dihydrofolate reductase n=13 Tax=Streptococcus RepID=B9DU71_STRU0
          Length = 165

 Score =  155 bits (393), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 48/161 (29%), Positives = 80/161 (49%), Gaps = 3/161 (1%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
           I  I A   + VIG    +PW LP +L  FK  TLN  ++MGR T+E +  R LP R+ +
Sbjct: 5   IIAIWAEDENGVIGANGTLPWYLPKELQHFKNTTLNHAILMGRVTFEGMKRRLLPNRQTL 64

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACG-DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +L+S      D    + S+++ +         + VIGG +V + F     K+  T +  +
Sbjct: 65  VLTSDESYHVDGALTMTSLEKTLEWYHAQENNLYVIGGQKVLQTFDGHFNKIIKTVVHHQ 124

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            +GDT+ P+ +   +      F++ D QN + +   IL R+
Sbjct: 125 FDGDTYRPELDLSPFVEEDCFFYERDDQNPYDFTVHILVRK 165


>UniRef50_C8WAC3 Dihydrofolate reductase region n=5 Tax=Coriobacteriaceae
           RepID=C8WAC3_ATOPD
          Length = 162

 Score =  155 bits (393), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 46/161 (28%), Positives = 77/161 (47%), Gaps = 6/161 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60
           ++ I ++  D  IG +  +     AD+ +F  +T +  VIMGR T ES    PL GR+NI
Sbjct: 1   MNAIVSVTRDWGIGCDGDLLIPNKADMKYFVEHTRSCTVIMGRKTLESFPGGPLKGRRNI 60

Query: 61  ILSSQPGTD-DRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           ++S       + V  V S +EA+    D    ++ +IGG  +Y   L +    Y+T  D 
Sbjct: 61  VISRNTNYQVEGVEIVSSAEEALRLVKDEAPEKVWLIGGASIYRALLDRCSYAYVTKHDT 120

Query: 118 EVEGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCFEILE 157
            V+ DT+FP+ + D  W+    E      +   ++ F   +
Sbjct: 121 VVDADTYFPNLDEDPAWKVCNEEDGGVTPE-GVAFKFVTYQ 160


>UniRef50_B9YFM0 Dihydrofolate reductase region n=3 Tax=Nostocaceae
           RepID=B9YFM0_ANAAZ
          Length = 166

 Score =  154 bits (390), Expect = 8e-37,   Method: Composition-based stats.
 Identities = 53/167 (31%), Positives = 89/167 (53%), Gaps = 13/167 (7%)

Query: 1   MISLIAALAVDRVIGMEN------AMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPL 54
           +ISLIAA++ +R++           +PW++P+DL  F++ T   PVI+GR ++ +   PL
Sbjct: 3   LISLIAAISENRILADSKKEHIRVGIPWDIPSDLQHFQKKTWRHPVILGRKSYAAFNHPL 62

Query: 55  PGRKNIILSSQPGT-DDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLY 111
           P R NIIL+              S+ EA+      +  EI + GGG ++ + +  A KLY
Sbjct: 63  PNRTNIILTRSHDYKAPGCLVFYSLSEAVTWAKMSEKEEIFIAGGGEIFAEAIKFANKLY 122

Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           LT ++   EGD +FP++   ++ +V  E H    +N   + F  +ER
Sbjct: 123 LTIVEGNFEGDVYFPEF--TNFGTVTKEEH--SQENDFQFKFVEIER 165


>UniRef50_C4QMV9 Dihydrofolate reductase n=1 Tax=Schistosoma mansoni
           RepID=C4QMV9_SCHMA
          Length = 186

 Score =  154 bits (390), Expect = 8e-37,   Method: Composition-based stats.
 Identities = 53/177 (29%), Positives = 88/177 (49%), Gaps = 21/177 (11%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL------NKPVIMGRHTWESIG---R 52
           ++++ A++ +  IG    +PW +  D+ +FK  T          V+MGR TWESI    +
Sbjct: 3   LNVVVAVSENWGIGKGGGLPWKIKKDMEFFKTVTTKAHPGLKNAVVMGRVTWESIPESFK 62

Query: 53  PLPGRKNIILSSQPGTDDR-VTWVKSVDEAIAACGDVP------EIMVIGGGRVYEQFLP 105
           PL  R NI++SS        V  V S++ AI    +        E+ +IGG R+Y++ L 
Sbjct: 63  PLKDRINIVVSSTLSHAPSFVQVVPSLNAAIDLLYNEEFSSIVDEVFIIGGYRLYKEALK 122

Query: 106 ---KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDAD--AQNSHSYCFEILE 157
                 ++Y THI +EV+ DT+FP  + D  + V      AD   +N  ++ F + +
Sbjct: 123 QSIYPVRIYCTHILSEVDCDTYFPKVDWDKLKKVDLPDIPADTFTENGFTFKFCVYD 179


>UniRef50_C2CJZ1 Possible dihydrofolate reductase n=3 Tax=Anaerococcus
           RepID=C2CJZ1_9FIRM
          Length = 162

 Score =  154 bits (389), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 47/160 (29%), Positives = 74/160 (46%), Gaps = 5/160 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + +I A+  +  IG    M +++  DL  FK  T     IMGR T+ES+G  LP R+N+I
Sbjct: 1   MKIILAVDKNWGIGKNGKMLFHIKKDLGHFKELTSGNICIMGRKTYESMGGALPNRENLI 60

Query: 62  LSSQPGT-DDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           LS                 +  +   D   E+ VIGG ++ E FL    +  +T I AE 
Sbjct: 61  LSRNKTYQAPDALVFNDYRDIFSYLEDKDKEVFVIGGEKIVELFLDFCDEAIITKIYAER 120

Query: 120 EGDTHFPDYEPDD-WESVFSEFHDADAQNSHSYCFEILER 158
             D+   +++ DD WE +     D   +N  S+ + +  R
Sbjct: 121 LADSFLHNFDSDDRWEVISK--SDIMEENGVSFQYIVYRR 158


>UniRef50_C0EGY7 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum
           DSM 5476 RepID=C0EGY7_9CLOT
          Length = 319

 Score =  153 bits (388), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 55/168 (32%), Positives = 85/168 (50%), Gaps = 12/168 (7%)

Query: 1   MISL--IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPG 56
           MI +  I A+     IG EN + +++P D+A+F++ TLNK V+MGRHT ES+   RPL  
Sbjct: 1   MIKMKCIVAVDQAWGIGCENGLLYSIPEDMAFFRKTTLNKAVVMGRHTLESLPKSRPLKN 60

Query: 57  RKNIILSSQPGTD-DRVTWVKSVDE---AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112
           R NI++S              S+ +   A++ C D  ++ V+GG  VY   L    +  +
Sbjct: 61  RLNIVMSRDRSLQIGGAITCCSLQDLGVALSIC-DSDDVYVMGGYAVYSLLLDFCGQALI 119

Query: 113 THIDAEVEGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCFEILERR 159
           T I  + E D  FP+ + D +W    SE  D  + N   Y F +   +
Sbjct: 120 TKIQGQREADRFFPNIDRDNNWTL--SEQSDVRSHNGLCYSFCVYANK 165


>UniRef50_UPI000186EC32 Dihydrofolate reductase, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186EC32
          Length = 190

 Score =  153 bits (387), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 54/177 (30%), Positives = 80/177 (45%), Gaps = 20/177 (11%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51
            +LIAA+  +  IG +  +PWNL  +L +F R T +         VIMGR TW+S+    
Sbjct: 5   FNLIAAVCSNNGIGYKGNLPWNLRKELQYFNRMTKDVKNPEKKNAVIMGRKTWDSLPHNW 64

Query: 52  RPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLP 105
           +PLPGR N +L++Q    D       +++ I           +    VIGG +VYE  L 
Sbjct: 65  KPLPGRYNFVLTTQSLNLDGAVVCSDLNDLIKKINSPDYSNLIETAWVIGGSKVYESVLK 124

Query: 106 K--AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDA--DAQNSHSYCFEILER 158
                + YLT I  E E D  F      D++ V  +        +N   Y F + E+
Sbjct: 125 YGLCHRFYLTRIKKEFECDCFFNYDFTKDFKEVSDDRVPKGVQKENEIEYVFHVYEK 181


>UniRef50_B4D395 Dihydrofolate reductase region n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4D395_9BACT
          Length = 201

 Score =  152 bits (385), Expect = 3e-36,   Method: Composition-based stats.
 Identities = 57/189 (30%), Positives = 88/189 (46%), Gaps = 45/189 (23%)

Query: 8   LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQP- 66
           ++++RVIG +N +PW+LP D  WFK+ T    V+MGR T+ES+GRPLP R NI+++ +P 
Sbjct: 1   MSLNRVIGRDNKIPWHLPEDFKWFKKLTTGHFVLMGRKTFESLGRPLPNRTNIVVTRKPL 60

Query: 67  ----------------------------------GTDDRVTWVKS---VDEAIAACGDVP 89
                                              ++  V  V+    + +A        
Sbjct: 61  RLARDPQFKATVGQARVGHWQARFGRPYQLGFERLSERDVWLVRDPRKLADAFEKARPSR 120

Query: 90  EIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSH 149
           ++ VIGG ++YEQ LP+   LYL+ +  EVEGD  FP+   DDW    +     D     
Sbjct: 121 QLFVIGGAQIYEQLLPRCTDLYLSVVQREVEGDACFPEL-EDDWYLHDTPLRTPD----- 174

Query: 150 SYCFEILER 158
            +  +   R
Sbjct: 175 -FEVQHYRR 182


>UniRef50_C4V3M4 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase protein n=1
           Tax=Selenomonas flueggei ATCC 43531 RepID=C4V3M4_9FIRM
          Length = 322

 Score =  152 bits (385), Expect = 4e-36,   Method: Composition-based stats.
 Identities = 47/164 (28%), Positives = 66/164 (40%), Gaps = 16/164 (9%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59
           + LIAA+     IG    +  + P D+A F+R T+   V+MGR T ES+   RPL GR N
Sbjct: 167 LELIAAVDDAGGIGRAGHLLTDCPEDMAHFRRMTMGGIVVMGRRTMESLPGRRPLVGRMN 226

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAA-----CGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114
           I+LS      D       +             +   I VIGG   Y   LP   + Y+T 
Sbjct: 227 IVLSRTMQETDGFYAAADILALWRLLGRLTAEEARPIFVIGGAACYRLLLPYVWRAYVTR 286

Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +    + D  FP  +   +    S              FE+ ER
Sbjct: 287 LLGSYDADVFFPSLD--GFSMTSSSAGQ-------DCIFEVYER 321


>UniRef50_C5BYZ5 Dihydrofolate reductase n=1 Tax=Beutenbergia cavernae DSM 12333
           RepID=C5BYZ5_BEUC1
          Length = 169

 Score =  152 bits (384), Expect = 4e-36,   Method: Composition-based stats.
 Identities = 53/169 (31%), Positives = 83/169 (49%), Gaps = 12/169 (7%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           MI +I A A D VIG    +PW++P D A FK  T    V+MGR TW+S+    RP+P R
Sbjct: 1   MIGMIWAQAHDGVIGARGTVPWHVPEDFAHFKATTRGHAVVMGRATWDSLPDRYRPMPER 60

Query: 58  KNIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           +N++++ Q     D      S+ +A+  C   PE  ++GG ++Y + +P A  L +T +D
Sbjct: 61  RNVVVTRQVDWSADGAERAGSIPDALERCAAEPETWIMGGAQIYAEAMPYADTLVVTQLD 120

Query: 117 --AEVEG--D-THFPDYEPDDWESVFSEFHDA--DAQNSHSYCFEILER 158
              +VEG  D  H P   P +W      +      ++    +      R
Sbjct: 121 LALDVEGAPDVVHAPPIGP-EWRIATDTWDGTWQTSRTGVRWQVHQYVR 168


>UniRef50_C8NZB9 Dihydrofolate reductase n=1 Tax=Erysipelothrix rhusiopathiae ATCC
           19414 RepID=C8NZB9_ERYRH
          Length = 150

 Score =  152 bits (384), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 44/159 (27%), Positives = 81/159 (50%), Gaps = 11/159 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI +I A+   R IG+  +MPW+   DL  F+++TLN+ V+MGR T+E + + L  R+  
Sbjct: 1   MIKIIVAMNNHRTIGLNGSMPWHNKEDLQHFRKSTLNQKVVMGRKTFEGLPKKLDNREIY 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAI-AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           +++     ++ +     +   +        +I + GGG +Y Q LP A +L +++I  +V
Sbjct: 61  VVTRNASIENAI---PDLRAFLMQHKESSEDIFIAGGGEIYAQSLPFAHELIISYIPNDV 117

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            GDT FPD+   +++      +        ++     ER
Sbjct: 118 IGDTFFPDFSDLEFKIKNQVEYS-------TFKQVTYER 149


>UniRef50_P78218 Dihydrofolate reductase type 15 n=153 Tax=root RepID=DYR15_ECOLX
          Length = 157

 Score =  152 bits (384), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 51/160 (31%), Positives = 91/160 (56%), Gaps = 9/160 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SL+AA++ + VIG    +PW+   +   FK  T N+ +++GR T+ES+G  LP RK  +
Sbjct: 3   LSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMG-ALPNRKYAV 61

Query: 62  LSSQPGT--DDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++    T  D+ V    S+DEA+     +   ++V GGG +Y+  + K   L+++ ID E
Sbjct: 62  VTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDIE 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            EGD +FP+  P  +  VFS+   ++     +Y ++I ++
Sbjct: 122 PEGDVYFPEI-PSSFRPVFSQDFVSN----INYSYQIWQK 156


>UniRef50_A3DES9 Dihydrofolate reductase n=5 Tax=Clostridium RepID=A3DES9_CLOTH
          Length = 167

 Score =  151 bits (383), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 48/161 (29%), Positives = 76/161 (47%), Gaps = 8/161 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59
           +  I A+  +  IG +  +   +P D+ +F++ TLNK V+MGR T+ES+    PL  R N
Sbjct: 1   MKAIVAVDSNWGIGYKGNLLQRIPEDMRFFRQMTLNKVVVMGRKTFESLPGKEPLKDRVN 60

Query: 60  IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           IILS     + D +   +SVD         +  +I VIGG  VY Q LP   + ++T  +
Sbjct: 61  IILSKSENIEKDGIIICRSVDGLFLELKKYNSDDIFVIGGEEVYTQLLPYCSEAHVTKFN 120

Query: 117 AEVEGDTHFPDYEP-DDWESVFSEFHDADAQNSHSYCFEIL 156
                D +FP+ +  + W+ V     +    N   Y     
Sbjct: 121 GAYSADRYFPNLDEMEGWKLVC--VGEPKEFNDIRYNRLKY 159


>UniRef50_D2SDU7 Dihydrofolate reductase n=1 Tax=Geodermatophilus obscurus DSM 43160
           RepID=D2SDU7_9ACTO
          Length = 176

 Score =  151 bits (383), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 59/163 (36%), Positives = 85/163 (52%), Gaps = 8/163 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           + L+ A A   VIG +  +PW+LP DL  F+  T    V+MGR TWES+    RPLPGR+
Sbjct: 3   VGLVWAQARGGVIGADGRLPWHLPEDLRLFRELTTGSTVVMGRRTWESLPERFRPLPGRR 62

Query: 59  NIILSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           N++L++      D    V  V++ +A   D  ++ VIGGGRVY  FLP A ++ +T +D 
Sbjct: 63  NVVLTTDRSWAADGAERVDGVEDVLARTDDG-DLWVIGGGRVYAAFLPHADRVVVTDVDT 121

Query: 118 EVEGDTHFPDYEPDDWESVFSEF--HDADAQNSHSYCFEILER 158
           +VEGDT  P     +W  V        + +     Y      R
Sbjct: 122 DVEGDTWAPQLGA-EWARVSRTPASGWSASTTGLRYAVSGYTR 163


>UniRef50_Q934V0 Putative dihydrofolate reductase n=1 Tax=Salmonella enterica subsp.
           enterica serovar Typhi RepID=Q934V0_SALTI
          Length = 158

 Score =  151 bits (383), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 49/160 (30%), Positives = 82/160 (51%), Gaps = 6/160 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           + +IAA+  +  IG+ N +PW  P DL  FK+ T N  V+MGR T ES+ RPLP R N++
Sbjct: 1   MKMIAAVGRNYEIGIGNELPWRCPTDLKLFKQLTKNATVVMGRKTMESLKRPLPERHNLV 60

Query: 62  LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121
           L+   G      +   +D+ +        + VIGGG++Y  F+P  ++++L+HI  +V G
Sbjct: 61  LTRSRGYIPNGFYPAGIDDVLRL---PDPVWVIGGGQIYSLFMPHVEEIWLSHIGVDVPG 117

Query: 122 -DTHFPD--YEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            D  FP        +  V + +     ++   +   +  R
Sbjct: 118 ADAFFPAPMMRSLGFVPVETAYTQRANEDEPGFLQIVYRR 157


>UniRef50_Q4JX60 FolA protein n=3 Tax=Corynebacterium RepID=Q4JX60_CORJK
          Length = 234

 Score =  151 bits (383), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 56/195 (28%), Positives = 83/195 (42%), Gaps = 39/195 (20%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58
           I +I A   D VIG    MPW LP DL  FK  T   PV+MGR +WE++    RPLP R 
Sbjct: 42  IGMIWAQTTDGVIGDGADMPWYLPEDLKHFKNATSGYPVVMGRTSWEALDDGFRPLPDRT 101

Query: 59  NIILSSQPGTD-DRVTWVKSVDEAIAACGDV-------------------PEIMVIGGGR 98
           N +++ Q   D        S+  A+A   +                    P + V+GGG+
Sbjct: 102 NYVITRQDNYDAPGGIVEPSIPSALANAAEQILNELTDSADKGEGADDRTPTVWVLGGGQ 161

Query: 99  VYEQFLPKAQKLYLTHIDAE----VEGDTHFPDYEPDDWESVFSEF----------HDAD 144
           VY Q +P A ++ +T ID E     +   + P    +++E    ++           + D
Sbjct: 162 VYAQCMPVADRIVITEIDMEAPERFQ--VYAPLVPEEEFEESAQDWQESEKGHPVDQEVD 219

Query: 145 AQNSHSYCFEILERR 159
            +    Y F    RR
Sbjct: 220 TEQPLRYRFCTWTRR 234


>UniRef50_UPI0001926A4C PREDICTED: similar to Dihydrofolate reductase CG14887-PB n=1
           Tax=Hydra magnipapillata RepID=UPI0001926A4C
          Length = 189

 Score =  151 bits (382), Expect = 7e-36,   Method: Composition-based stats.
 Identities = 55/177 (31%), Positives = 84/177 (47%), Gaps = 22/177 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL-------NKPVIMGRHTWESIG--- 51
           +  IAA+  +  IG++  +PWNLP +  +F+  T           VIMG++TW SI    
Sbjct: 7   VHCIAAIDSEWGIGLKGKLPWNLPREYKFFQNITTKVISEGKQNAVIMGKNTWFSIPQQH 66

Query: 52  RPLPGRKNIILSSQ---PGTDDRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQ 102
           RPL  R N+ILSS          V    S++ AI    D         I VIGG RVY++
Sbjct: 67  RPLKNRLNVILSSSFIKEDYPKNVLLESSLEAAILRLSDEFYANTVENIFVIGGSRVYKE 126

Query: 103 FLP-KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHD--ADAQNSHSYCFEIL 156
            +     K+YLT I+ +   D  +P ++ + ++ +  E  D     +N  SY F + 
Sbjct: 127 AMEKFCDKIYLTKIEQDYSCDVFYPIFDTNKFKEIDDEEVDKNKQIENGVSYTFHVY 183


>UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraurelia
           RepID=DRTS_PARTE
          Length = 462

 Score =  151 bits (381), Expect = 9e-36,   Method: Composition-based stats.
 Identities = 44/162 (27%), Positives = 84/162 (51%), Gaps = 6/162 (3%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60
            S++ A+ ++  IG +N +PW L  DL  FK+ T    VIMGR T+ES+  +PLP R N+
Sbjct: 7   FSMVLAMTLNGGIGYQNRLPWKLKEDLQRFKKITTGGIVIMGRKTFESMNSKPLPNRVNV 66

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACG-DVPEIMVIGGGRVYEQFL--PKAQKLYLTHIDA 117
           ++S    + + V     +++A+        ++ +IGG R++E+ L   K   ++LT I  
Sbjct: 67  VISKNMKSSNEVQVFPRIEDALQFYNTSHQKLYLIGGKRIFEEGLATDKCSDVHLTRIGV 126

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
           E + D +        ++   ++     ++N  +Y ++ L  +
Sbjct: 127 ETKCDVYLNKNIFSTFQV--NKTSQTKSENGINYDYQHLINK 166


>UniRef50_A9HP20 Dihydrofolate reductase n=1 Tax=Roseobacter litoralis Och 149
           RepID=A9HP20_9RHOB
          Length = 154

 Score =  150 bits (380), Expect = 1e-35,   Method: Composition-based stats.
 Identities = 50/157 (31%), Positives = 82/157 (52%), Gaps = 9/157 (5%)

Query: 6   AALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIILSS 64
            A A +  IG +  +PWN+P DL +F+R TL   +IMGR+TWES+  +PLP R N+++SS
Sbjct: 1   MARAENGAIGRDGTIPWNVPEDLKFFQRETLGGALIMGRNTWESLPVKPLPRRFNVVVSS 60

Query: 65  QPGTDDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV-EG 121
              T +      SV  AI          I  IGG  +Y++ LP A +L ++ +  +V + 
Sbjct: 61  NSDTAE--VVAPSVKVAIELAIEHGHQRIYGIGGAAIYQEMLPLAHRLLISEVQIDVPDA 118

Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           DT FP+++   W+++ +         + +       R
Sbjct: 119 DTFFPNFDVAGWKAIDTRPLRGQ---APACSVHEYLR 152


>UniRef50_Q8JKV3 Dihydrofolate reductase n=1 Tax=Heliothis zea virus 1
           RepID=Q8JKV3_9VIRU
          Length = 264

 Score =  150 bits (380), Expect = 1e-35,   Method: Composition-based stats.
 Identities = 59/174 (33%), Positives = 87/174 (50%), Gaps = 18/174 (10%)

Query: 2   ISLIAALAVDR-VIGMENAMPWNLPADLAWFKRNTL------NKPVIMGRHTWESIG--- 51
           I+LI A+  +   IGM NA+PW+L  ++A F + T          VIMGR TWESI    
Sbjct: 87  INLIVAVCENNMGIGMNNALPWHLKREMAHFTKTTTTATHPNKNAVIMGRLTWESIPKRF 146

Query: 52  RPLPGRKNIILSSQPGTD-DRVTWVKSVDEAIAACGDVPEI---MVIGGGRVYEQFL--P 105
           RPLPGR NI+L+++   D D  T V + DEAI       +I    VIGG  VY   +  P
Sbjct: 147 RPLPGRVNIVLTTKHRGDYDGATRVSNFDEAIRVVESRGDIETAWVIGGASVYAAAMTHP 206

Query: 106 KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
              +++LT I    E +  FP  +   +E +         +    Y +++ ++R
Sbjct: 207 NCHQIHLTAIKKYYECNVFFPKIDTTRFELISET--PCTREGDVQYSYKVYQQR 258


>UniRef50_P00381 Dihydrofolate reductase n=9 Tax=Lactobacillus RepID=DYR_LACCA
          Length = 163

 Score =  149 bits (378), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 45/163 (27%), Positives = 81/163 (49%), Gaps = 5/163 (3%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           M + + A   D +IG +  +PW+LP DL +F+  T+ K +++GR T+ES   RPLP R N
Sbjct: 1   MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN 60

Query: 60  IILSSQPGTDDRV---TWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116
           ++L+ Q     +        +   A A      E+++ GG +++  F      L +T + 
Sbjct: 61  VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA 120

Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
              EGDT       DD+  V S   + D   + ++ +E+ +++
Sbjct: 121 GSFEGDTKMIPLNWDDFTKVSSRTVE-DTNPALTHTYEVWQKK 162


>UniRef50_C5IWK1 Dihydrofolate reductase n=15 Tax=Bacteria RepID=C5IWK1_ECOLX
          Length = 157

 Score =  149 bits (378), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 42/160 (26%), Positives = 84/160 (52%), Gaps = 9/160 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           IS++AA++ + VIG    +PW++  +   FK  T N  +++GR T++S+G+ LP RK  +
Sbjct: 3   ISIMAAVSENGVIGSGLDIPWHVQGEQLLFKAMTYNHWLLVGRKTFDSMGK-LPNRKYAV 61

Query: 62  LSSQP--GTDDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++       D  V +  S++ A++   +    + V GGG +Y+  + +A  ++L+ I   
Sbjct: 62  VTRSEMVSNDPDVIYFTSIESALSYLDNTTTHVFVSGGGEIYKALIEQADVIHLSVIHKH 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + GD  FP   P  ++  F +   ++      Y ++I  +
Sbjct: 122 ISGDVFFPSV-PQSFKQTFEQSFSSN----IDYTYQIWAK 156


>UniRef50_Q7VQK5 Dihydrofolate reductase type I n=1 Tax=Candidatus Blochmannia
           floridanus RepID=Q7VQK5_BLOFL
          Length = 168

 Score =  148 bits (375), Expect = 5e-35,   Method: Composition-based stats.
 Identities = 63/166 (37%), Positives = 95/166 (57%), Gaps = 8/166 (4%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           +ISLIAA  ++ VIG +N +PW    D+ WFK +T+ KPVIMGR T+ES+  +PLP R N
Sbjct: 2   IISLIAAFTINYVIGRKNIIPWYFSWDMMWFKYHTMYKPVIMGRKTFESMNSKPLPYRLN 61

Query: 60  IILSSQP----GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115
           I+LS            +    +  +A++      E+M+IGGG VY  F+ +  ++YLT I
Sbjct: 62  IVLSKHHILYNNKIHNIFIACNPIQALSVVQKNDEVMIIGGGLVYNAFMSQCTRMYLTKI 121

Query: 116 DAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSY--CFEILER 158
           D     GD+ FP Y P++W  V++          ++Y   F+IL+R
Sbjct: 122 DVVYNYGDSWFPSYNPNEWCVVYNTNKKCVINTGYTYNLNFQILDR 167


>UniRef50_C5RC79 Dihydrofolate reductase n=1 Tax=Weissella paramesenteroides ATCC
           33313 RepID=C5RC79_WEIPA
          Length = 168

 Score =  148 bits (375), Expect = 5e-35,   Method: Composition-based stats.
 Identities = 51/161 (31%), Positives = 83/161 (51%), Gaps = 4/161 (2%)

Query: 3   SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNII 61
           +LI A  +D  I ++  +PW+  ADL +FK++T+++  +MGRHT  S  GRPLP R N++
Sbjct: 8   NLIWAQTLDGTIAIDGHIPWHQKADLQFFKQSTIHEAALMGRHTMASFHGRPLPERLNLV 67

Query: 62  LSSQPGT--DDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           L+        +    V SV EA     +   ++ VIGG  +YE F+  A  LY+T++  +
Sbjct: 68  LTRNHDLEVPEGFQKVYSVAEAEKVADNANLKLQVIGGKPIYESFMDTADTLYVTYLQTD 127

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
             GD      +   W+    +   ADA N + +      R+
Sbjct: 128 FSGDVKMAPVDLTVWQGEVIDQGPADADNDYDWRLVKYTRQ 168


>UniRef50_B2GI60 Dihydrofolate reductase n=3 Tax=Actinomycetales RepID=B2GI60_KOCRD
          Length = 183

 Score =  148 bits (375), Expect = 5e-35,   Method: Composition-based stats.
 Identities = 59/181 (32%), Positives = 87/181 (48%), Gaps = 25/181 (13%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57
           M+  I A + D VIG++  +PW+L  DL +F R T+  PVIMGR TWES     RPLPGR
Sbjct: 1   MVGAIWAQSPDGVIGVDGGIPWHLSEDLKFFARTTIGHPVIMGRRTWESFPEQFRPLPGR 60

Query: 58  KNIILSSQPGTD----DRVTWVKSVDEAIAAC------------GDVPEIMVIGGGRVYE 101
            NI+++S+P +     +RV  V S  EA+                   E+ VIGG  V+ 
Sbjct: 61  PNIVITSRPESVPADGERVWAVGSYAEALELAVSLLAAPGPEHEEPAREVWVIGGPGVWR 120

Query: 102 QFLPK----AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157
           + +        +  +T +D +V GDTH P  +   W          +A+N   +  +   
Sbjct: 121 EAVSHRPLPLTRALVTTVDLDVTGDTHAPALD-GSWSR-REVAGWTEARNGTWFRIDEWT 178

Query: 158 R 158
           R
Sbjct: 179 R 179


>UniRef50_P11731 Dihydrofolate reductase type 5 n=27 Tax=Bacteria RepID=DYR5_ECOLX
          Length = 157

 Score =  147 bits (373), Expect = 8e-35,   Method: Composition-based stats.
 Identities = 54/160 (33%), Positives = 90/160 (56%), Gaps = 9/160 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SL+AA A + VIG    +PW+   +   FK  T N+ +++GR T+ES+G  LP RK  +
Sbjct: 3   VSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAV 61

Query: 62  LSSQPGTD--DRVTWVKSVDEAIA-ACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           ++    T   D V    S++EA+         ++V GGG +Y + LP A  L+++ ID E
Sbjct: 62  VTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIE 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
            EGD  FP+  P+ +E VF +   ++     +YC++I ++
Sbjct: 122 PEGDVFFPNI-PNTFEVVFEQHFSSN----INYCYQIWQK 156


>UniRef50_C0VZ67 Possible dihydrofolate reductase n=3 Tax=Actinomycetaceae
           RepID=C0VZ67_9ACTO
          Length = 170

 Score =  147 bits (373), Expect = 9e-35,   Method: Composition-based stats.
 Identities = 52/169 (30%), Positives = 90/169 (53%), Gaps = 11/169 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR--PLPGRK 58
           ++ +I A   +  +G  + M W++PAD   FK++T+  P+IMGR +W+++GR  PLP R+
Sbjct: 3   VVKMIWAQDAEGKLGSGSEMLWHVPADFRHFKQSTVGFPLIMGRKSWDALGRFAPLPQRR 62

Query: 59  NIILSSQPGT-DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHID 116
           NI+++       +      S++EAI+      E + + GG  +YEQ +P A +L +T++D
Sbjct: 63  NIVVTRNRDFIPEGGEVAFSIEEAISLASADSELVWIAGGAHIYEQAMPFADELVVTYLD 122

Query: 117 AEVEGD---THFPDYEPDDWESVFSEFHDADAQ---NSHSYCFEILERR 159
             V       + P  +P  WE V +E  DAD +       +   +  RR
Sbjct: 123 LNVSTAGPVVYAPQIDPAVWEVVKAE-SDADWREKSGDARWKVVVYRRR 170


>UniRef50_C2D6N3 Possible dihydrofolate reductase n=1 Tax=Atopobium vaginae DSM
           15829 RepID=C2D6N3_9ACTN
          Length = 186

 Score =  147 bits (371), Expect = 1e-34,   Method: Composition-based stats.
 Identities = 42/175 (24%), Positives = 73/175 (41%), Gaps = 19/175 (10%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKN 59
           MI  I ++  D  IG +  +     AD+  F R T    VIMG  T+E+  + PL  R+N
Sbjct: 11  MIKAIVSVTQDWGIGYKGELLVPNKADMQHFVRMTTGACVIMGSTTFETFPKGPLKNRRN 70

Query: 60  IILSSQPGTD----------------DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQF 103
           I+L+     +                       S  +A++      ++ +IGG   Y+QF
Sbjct: 71  IVLAQTHSYEREGFPKTTCTEQGTSVQNYEVYTSTQDALSHIKPDEDVWIIGGAYTYQQF 130

Query: 104 LPKAQKLYLTHIDAEVEGDTHFPDYEP-DDWESVFSEFHDADAQNSHSYCFEILE 157
           LP   ++ +T  D   + D +FP+ +  DDW    +      ++    + F   +
Sbjct: 131 LPYCTEVVVTKNDCIRQADAYFPNLDKMDDWRITSTTEGGITSE-GVHFLFVTYQ 184


>UniRef50_Q86ZU9 Dihydrofolate reductase n=2 Tax=Agaricales RepID=Q86ZU9_COPCI
          Length = 205

 Score =  147 bits (371), Expect = 1e-34,   Method: Composition-based stats.
 Identities = 48/200 (24%), Positives = 76/200 (38%), Gaps = 43/200 (21%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT------LNKPVIMGRHTWESIG---R 52
           +++I A      IG  + +PW L  ++ +F R T          V+MGR TWESI    R
Sbjct: 4   LTIIVAATKANGIGKGSNLPWRLAKEMKYFARATSEAPEGTRNAVVMGRTTWESIPEKFR 63

Query: 53  PLPGRKNIILSSQPGTD--------DRVTWVKSVDEAIAACGDVP-----EIMVIGGGRV 99
           PLP R N+++S     +               S+   +             I VIGG  +
Sbjct: 64  PLPNRVNVVVSRNENYELEPGKEPSPMARLANSLSSGLRHLTTTDGLTVNRIFVIGGASL 123

Query: 100 YEQFL--------PKAQKLYLTHI-DAEVEGDTHFPDYEPD--DWESV----------FS 138
           Y + L        P   ++ LT I + + + D   P++  D  +W             FS
Sbjct: 124 YRETLSLARSKTGPFVDRILLTRIVEPDFDCDVFMPEFNADGKEWTRSTHAELQEWVGFS 183

Query: 139 EFHDADAQNSHSYCFEILER 158
                  +N   Y F++  R
Sbjct: 184 VPEGIQEENGVKYEFQMWTR 203


>UniRef50_UPI000180BE95 PREDICTED: similar to GJ10259 n=1 Tax=Ciona intestinalis
           RepID=UPI000180BE95
          Length = 194

 Score =  147 bits (371), Expect = 1e-34,   Method: Composition-based stats.
 Identities = 49/186 (26%), Positives = 83/186 (44%), Gaps = 29/186 (15%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN---------KPVIMGRHTWESIG- 51
           I  + A   +  IG +  +PW LP ++ +FKR T             VI+GR TWESI  
Sbjct: 8   IHSVVACCNNGGIGFKGRLPWRLPKEMKYFKRITTGEVEEFGGRRNVVIIGRKTWESIPK 67

Query: 52  --RPLPGRKNIILSS--QPGTDDRVTWVKSVDEAIAA------CGDVPEIMVIGGGRVYE 101
             +PL  R NI++S       +     V S+DE I        C  + ++  IGG  +Y+
Sbjct: 68  SFKPLKDRINIVISRTLDKDCEGPDLVVNSLDELIDLLHSKPWCDKINQVFNIGGNEIYK 127

Query: 102 QFLP--KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHD------ADAQNSHSYCF 153
                    K+YLT + A+++ DT   + + D++  + +E            +N   +  
Sbjct: 128 LIHNSQYCGKIYLTRVLADLQCDTFLENLD-DNFTKLPTEGFPEVPQGIQMDKNDLQWKV 186

Query: 154 EILERR 159
           E+ E++
Sbjct: 187 EVYEKK 192


>UniRef50_B7VPW7 Dihydrofolate reductase type I (Trimethoprim resistance) n=2
           Tax=Vibrio splendidus RepID=B7VPW7_VIBSL
          Length = 183

 Score =  146 bits (370), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 47/160 (29%), Positives = 86/160 (53%), Gaps = 9/160 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +SL+AA+A + VIG    +PW +  +   FK  T N+ +++GR T+ES+G+ LP RK  +
Sbjct: 29  LSLMAAVAENGVIGSGLDIPWIVKGEQLLFKAMTFNQWLLLGRKTFESMGK-LPNRKYAV 87

Query: 62  LSSQPGT--DDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +S  P T  D  + + KSV++A+           V GGG++Y+  + +   ++++ I   
Sbjct: 88  ISRSPSTSNDPDILYFKSVEDALGYLETVTEHAFVSGGGQIYKSLITQVDTIHISKIHKH 147

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           + GD  FP+   D    VF +   ++      Y ++I ++
Sbjct: 148 ISGDIFFPELPRDL-TLVFEQRFSSN----IDYTYQIWQK 182


>UniRef50_A4GI75 Dihydrofolate reductase n=1 Tax=uncultured marine bacterium
           HF10_29C11 RepID=A4GI75_9BACT
          Length = 168

 Score =  146 bits (369), Expect = 3e-34,   Method: Composition-based stats.
 Identities = 51/167 (30%), Positives = 79/167 (47%), Gaps = 10/167 (5%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNK---PVIMGRHTWESIG---RPL 54
           M+ +I A+ +D  IG EN +PW L +D+  FKR T+ +    V+MGR TWE+I    RPL
Sbjct: 2   MLKMILAMDLDGCIGKENGLPWRLQSDMLRFKRLTIGQGNSAVLMGRTTWETIPERFRPL 61

Query: 55  PGRKNIILSSQPGTD-DRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLY 111
             R NI+++              S++  I      +  E  +IGG  VYEQ      +++
Sbjct: 62  VDRINIVVTRNRNYALSDAHVTYSIENGIEHASNNNCDECWIIGGADVYEQCRDLVDEIH 121

Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           LT ++    GD     +  D+W     E     + N H   + IL +
Sbjct: 122 LTSVETSNSGDIKVGMFG-DEWNREIIESTPESSDNEHPTTYMILRK 167


>UniRef50_Q59397 Dihydrofolate reductase type 9 n=1 Tax=Escherichia coli
           RepID=DYR9_ECOLX
          Length = 177

 Score =  146 bits (368), Expect = 3e-34,   Method: Composition-based stats.
 Identities = 49/164 (29%), Positives = 75/164 (45%), Gaps = 11/164 (6%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           +++I A+     IG EN +PW+ P DL  FK  T+N  +IMGR T+ S+ + LPGR +++
Sbjct: 4   LNMIVAVNKTGGIGFENQIPWHEPEDLKHFKAVTMNSVLIMGRKTFASLPKVLPGRLHVV 63

Query: 62  LSSQ---PGTDDRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYL 112
           +S         D+V +V +   A+          +  +I VIGG   YE       KLYL
Sbjct: 64  VSKTVPPTQNTDQVVYVSTYQIAVRTASLLVDKPEYSQIFVIGGKSAYENLAAYVDKLYL 123

Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
           T +    + DT         W+ V         +N     F+I 
Sbjct: 124 TRVQLNTQQDTELDLSLFKSWKLVSEV--PTITENKTKLIFQIW 165


>UniRef50_D1AYS8 Dihydrofolate reductase region n=1 Tax=Streptobacillus moniliformis
           DSM 12112 RepID=D1AYS8_STRM9
          Length = 156

 Score =  146 bits (368), Expect = 3e-34,   Method: Composition-based stats.
 Identities = 51/161 (31%), Positives = 93/161 (57%), Gaps = 10/161 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           MI ++ A+  +  IG +N M W+   +L +F++ TLN  ++MG++T+ SIGRPL  R+NI
Sbjct: 1   MIHIVVAVGENNEIGKDNKMLWHNSEELRFFRKLTLNHKIVMGKNTYLSIGRPLDLRENI 60

Query: 61  ILSSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
           ++S+    ++ +  ++++D+ +    D  E I VIGG  +Y+QFL   +K+YL+ ID + 
Sbjct: 61  VISTTLEENEDIYVLRNIDKILEKYVDSDEIIYVIGGENIYKQFLKYTEKIYLSKIDGKF 120

Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159
            + D +FP    D+        +  +  N +++   I  RR
Sbjct: 121 PDADRYFPSINYDE--------YSTEVVNYNTFKLYIYTRR 153


>UniRef50_A8SSS6 Putative uncharacterized protein n=2 Tax=Bacteria
           RepID=A8SSS6_9FIRM
          Length = 168

 Score =  145 bits (367), Expect = 4e-34,   Method: Composition-based stats.
 Identities = 44/162 (27%), Positives = 69/162 (42%), Gaps = 8/162 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59
           +  IAA+  +  IG + ++   +  D   F++ T+   V++GR T E     RPL GR N
Sbjct: 1   MKFIAAVDNNWAIGNKGSLLVRISEDQKNFRKETMGHVVVLGRKTLEEFPGGRPLKGRTN 60

Query: 60  IILSSQPGT-DDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHID 116
           IILS+ P         V S+DE      +    +I +IGG  VY+  +P      +T ID
Sbjct: 61  IILSTNPDYTVQDAVVVHSIDELFEKLSEYESDDIFIIGGQTVYDVLIPYCDTGIVTKID 120

Query: 117 AEVEGDTHFPDYEP-DDWESVFSEFHDADAQNSHSYCFEILE 157
              E D    + +  D+W             N  +  F   +
Sbjct: 121 KSYEADAFIQNLDEMDNWHVENERSG--TEPNDVNITFVTYK 160


>UniRef50_P27422 Dihydrofolate reductase type 7 n=46 Tax=Bacteria RepID=DYR7_ECOLX
          Length = 157

 Score =  145 bits (367), Expect = 4e-34,   Method: Composition-based stats.
 Identities = 48/160 (30%), Positives = 91/160 (56%), Gaps = 9/160 (5%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61
           ISLI+A + + VIG    +PW+   +   FK  T N+ +++GR T++S+G  LP RK  +
Sbjct: 3   ISLISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMG-VLPNRKYAV 61

Query: 62  LSSQ--PGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118
           +S +    +++ V    S++ A+     +   + V GGG++Y   + KA  ++L+ +  E
Sbjct: 62  VSRKGISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHVE 121

Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           VEGD +FP   P+++  VF +F  ++     +Y ++I ++
Sbjct: 122 VEGDINFPKI-PENFNLVFEQFFLSN----INYTYQIWKK 156


>UniRef50_Q53D67 JM3 n=3 Tax=Macacine herpesvirus 5 RepID=Q53D67_9GAMA
          Length = 193

 Score =  145 bits (366), Expect = 5e-34,   Method: Composition-based stats.
 Identities = 50/181 (27%), Positives = 76/181 (41%), Gaps = 23/181 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPW-NLPADLAWFKRNTL-------NKPVIMGRHTWESIG-- 51
           ++ I A+     IG    MPW  L  ++ +F++ T           VIMG+ TW SI   
Sbjct: 5   VNCIVAVDKQLGIGKNGTMPWPYLKNEMMYFQKMTSTPSVIGEKNVVIMGKRTWFSIPEK 64

Query: 52  -RPLPGRKNIILSSQPGTDDRVTWV--KSVDEAI------AACGDVPEIMVIGGGRVYEQ 102
            RPL  R NIILS +     +      +++D+A            +  + VIGG  VYE 
Sbjct: 65  KRPLANRINIILSRELREPPKGAHFLARTLDDAFNFYRQYKLTKQLNTVWVIGGKSVYES 124

Query: 103 FLPKAQ--KLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDAD--AQNSHSYCFEILER 158
            L      KLY+T I    + D  FP     ++  +           +N   Y F++ E+
Sbjct: 125 VLNYECSLKLYITRIMESFDCDVFFPSINFTEYTMLSELPGKDTNFEENGIKYKFQVYEK 184

Query: 159 R 159
           R
Sbjct: 185 R 185


>UniRef50_P15093 Dihydrofolate reductase n=3 Tax=Halobacteriaceae RepID=DYR_HALVO
          Length = 162

 Score =  145 bits (366), Expect = 5e-34,   Method: Composition-based stats.
 Identities = 49/159 (30%), Positives = 82/159 (51%), Gaps = 12/159 (7%)

Query: 5   IAALAVDRVIGMENAMPW-NLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63
           +AALA +RVIG +  +PW ++PAD   ++    + PV++GR T+ES+   LPG   I++S
Sbjct: 6   VAALAENRVIGRDGELPWPSIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65

Query: 64  S--QPGTDDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119
              +  + D      SV+EA+      D     VIGG  +Y  F P   ++ L+ +  E 
Sbjct: 66  RSERSFSVDTAHRAASVEEAVDIAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEY 125

Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           EGDT++P+++  +WE      H+        +  +   R
Sbjct: 126 EGDTYYPEWDAAEWELDAETDHEG-------FTLQEWVR 157


>UniRef50_Q4SM73 Chromosome 13 SCAF14555, whole genome shotgun sequence n=2
           Tax=Tetraodon nigroviridis RepID=Q4SM73_TETNG
          Length = 198

 Score =  144 bits (364), Expect = 8e-34,   Method: Composition-based stats.
 Identities = 42/180 (23%), Positives = 76/180 (42%), Gaps = 23/180 (12%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIGR-- 52
           + LIAA      IG +N MPW+LP++  +F               +I G+  W S     
Sbjct: 11  VRLIAAKCNGGGIGKDNRMPWSLPSEFRFFLSTITRVSRPGKMNMIIWGKQCWISHPEST 70

Query: 53  -PLPGRKNIILSSQPGTDDR--VTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQF 103
            PLP   + +LS+             +++D A+    +      +  + ++GG +VY++ 
Sbjct: 71  FPLPNVLHTVLSTTLFAVPDHAHFVCETLDAAVRLASEPPLADLIEIVWIVGGVQVYKEA 130

Query: 104 L--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVF---SEFHDADAQNSHSYCFEILER 158
           +  P    +YLT I AE E D  FP+++   ++              +N   Y  ++ +R
Sbjct: 131 MEHPWCDLIYLTDIMAEFECDVFFPEFDRQLFQVQDGFPDVPDGIQEENGIKYKCQVYKR 190


>UniRef50_A8SNM7 Putative uncharacterized protein n=1 Tax=Parvimonas micra ATCC
           33270 RepID=A8SNM7_9FIRM
          Length = 166

 Score =  144 bits (364), Expect = 8e-34,   Method: Composition-based stats.
 Identities = 49/163 (30%), Positives = 82/163 (50%), Gaps = 9/163 (5%)

Query: 2   ISLIAALAVD-RVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           + LI A+      IG +N + + L  D+ +FK  T +  +I GR T+E    +PLP RKN
Sbjct: 6   LYLIVAITEKTNAIGKDNNLLYFLKEDMNFFKEKTCDNSIICGRKTFEGFKIKPLPKRKN 65

Query: 60  IILSSQPGTDDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           I+L+    + + V   K++++ I    +    +  V GG  +YEQ +    ++Y+T  + 
Sbjct: 66  IVLTKSDFSFEGVRRFKNIEDLINFVKENPKEKFFVCGGMSIYEQLIDFCSRMYITKYEE 125

Query: 118 E--VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
           +  VE D+HFP  +   W+ V  E  D  ++N     F   ER
Sbjct: 126 KEAVEADSHFPKIDEKVWKVV--EKIDGKSENP-KLTFYTYER 165


>UniRef50_C5VBQ6 Dihydrofolate reductase n=5 Tax=Corynebacterium RepID=C5VBQ6_9CORY
          Length = 160

 Score =  144 bits (364), Expect = 8e-34,   Method: Composition-based stats.
 Identities = 60/167 (35%), Positives = 84/167 (50%), Gaps = 20/167 (11%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59
           M+  I A  +  +IG   +MPW++P DL  FK+ TL  P+IMGR TWES+  RPLPGRKN
Sbjct: 1   MLRAIWAQNLMGLIGDGKSMPWHVPEDLQHFKKLTLGSPIIMGRRTWESLPVRPLPGRKN 60

Query: 60  IILSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           ++LS +      +  + + SV E            VIGGG VY   + K Q+++ T IDA
Sbjct: 61  LVLSRRTPGKWSNGASVIASVPE---------SGWVIGGGVVYAATIDKVQEIHRTLIDA 111

Query: 118 E---VE-GD--THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
                E GD     P   PD ++ V        + +   Y FE   +
Sbjct: 112 PTNLFELGDRAVFAPTIPPD-FQLVQHSKWLKSS-SGLRYKFETWTK 156


>UniRef50_Q8EV82 Dihyrofolate reductase n=1 Tax=Mycoplasma penetrans
           RepID=Q8EV82_MYCPE
          Length = 154

 Score =  144 bits (364), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 45/161 (27%), Positives = 79/161 (49%), Gaps = 11/161 (6%)

Query: 1   MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60
           M   I     +R IG  N +PWN+  DL  FK++TLN  ++MG++T+ SIG+ LP RKNI
Sbjct: 1   MFISIWCEDKNRGIGKNNKLPWNIKEDLNLFKKHTLNNTIVMGKNTFLSIGKALPNRKNI 60

Query: 61  ILSSQPGTD--DRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           ++S          +     +++      +  E I +IGG  +Y+ F+ K   LY++ +++
Sbjct: 61  VISKTLDASLYKDIEVYDDIEQFYNEYKNRDESIFIIGGKSIYDYFINKCSILYVSKLNS 120

Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158
             E D    +   D +E V  + ++        + F    +
Sbjct: 121 AYECDLFMDN-SFDGFEIVNQKEYEQ-------FTFFEYRK 153


>UniRef50_UPI00017450E9 dihydrofolate reductase type III n=1 Tax=Verrucomicrobium spinosum
           DSM 4136 RepID=UPI00017450E9
          Length = 179

 Score =  144 bits (363), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 50/162 (30%), Positives = 82/162 (50%), Gaps = 7/162 (4%)

Query: 2   ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60
           ++LIAA+  + ++     +PW LP D+A F+     K +++GRHT+E + G   P +  +
Sbjct: 8   LTLIAAVDENLLLATAQGIPWKLPDDVAHFRAYCAGKWLLLGRHTYEDMTGWFKPDQHPL 67

Query: 61  ILSSQPGTDDR-VTWVKSVDEAIAA--CGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117
           +L+S  G +      V SV +A+A        E++ IGGG+V+   LP A +L +THI  
Sbjct: 68  VLTSTCGYEPNPGRGVASVPQALALAEAEGQEELVCIGGGQVFATALPHATRLVITHIKH 127

Query: 118 EVE-GD--THFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156
             E GD   +FP    D W       H  D +++  + F   
Sbjct: 128 IFEPGDQPVYFPPISADAWREERRLDHAVDDRHAWPFTFVEY 169


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.317    0.168    0.548 

Lambda     K      H
   0.267   0.0513    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,385,597,991
Number of Sequences: 3077464
Number of extensions: 73629653
Number of successful extensions: 146274
Number of sequences better than 1.0e-01: 250
Number of HSP's better than  0.1 without gapping: 986
Number of HSP's successfully gapped in prelim test: 362
Number of HSP's that attempted gapping in prelim test: 142715
Number of HSP's gapped (non-prelim): 1414
length of query: 159
length of database: 1,040,396,356
effective HSP length: 118
effective length of query: 41
effective length of database: 677,255,604
effective search space: 27767479764
effective search space used: 27767479764
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.3 bits)
S2: 88 (38.2 bits)
