PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c3cseA_

Fold library id	PDB Header	Molecule	Title
c3cseA_	PDB header: oxidoreductase	Chain: A: PDB Molecule: dihydrofolate reductase;	PDBTitle: candida glabrata dihydrofolate reductase complexed with2 nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-3 ynyl)-6-ethylpyrimidine (ucp120b)

Links to external resources
Added to library: Tue Mar 16 14:29:52 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence K V P V V G I V A A L L P E M G I G F Q G N L P W R L A K E M K Y F R E V T T L T N D N S K Q N V V I M G R K T W E S I P Q K F R P L P K R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T T B T T B
S
S S T T
S
G G G
S
T T S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence I N V V V S R S F D G E L R K V E D G I Y H S N S L R N C L T A L Q S S L A N E N K I E R I Y I I G G G E I Y R Q S M D L A D H W L I T K I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S S S S
T T S
T
T T
T T T
S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence M P L P E T T I P Q M D T F L Q K Q E L E Q R F Y D N S D K L V D F L P S S I Q L E G R L T S Q E W N G E L V K G L P V Q E K G Y Q F Y F T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S
S
G G G S
T T
S S
T T T T

. . . . . . . . . 220 . . . . .

Sequence L Y T K K L E H H H H H H H H

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	K	V	P	V	V	G	I	V	A	A	L	L	P	E	M	G	I	G	F	Q	G	N	L	P	W	R	L	A	K	E	M	K	Y	F	R	E	V	T	T	L	T	N	D	N	S	K	Q	N	V	V	I	M	G	R	K	T	W	E	S	I	P	Q	K	F	R	P	L	P	K	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)												T	T	T	T				B	T	T	B		S																		S	S	T	T															S		G	G	G		S		T	T	S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	I	N	V	V	V	S	R	S	F	D	G	E	L	R	K	V	E	D	G	I	Y	H	S	N	S	L	R	N	C	L	T	A	L	Q	S	S	L	A	N	E	N	K	I	E	R	I	Y	I	I	G	G	G	E	I	Y	R	Q	S	M	D	L	A	D	H	W	L	I	T	K	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							T	T	S	S	S	S						T	T					S										T						T	T																		T	T	T		S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	M	P	L	P	E	T	T	I	P	Q	M	D	T	F	L	Q	K	Q	E	L	E	Q	R	F	Y	D	N	S	D	K	L	V	D	F	L	P	S	S	I	Q	L	E	G	R	L	T	S	Q	E	W	N	G	E	L	V	K	G	L	P	V	Q	E	K	G	Y	Q	F	Y	F	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				T	T	S						S																G	G	G					S		T	T				S	S								T	T											T	T
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.
Sequence	L	Y	T	K	K	L	E	H	H	H	H	H	H	H	H
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)